S. Homans

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Probing the Binding Entropy of Ligand–Protein Interactions by NMR

S. Homans, Steve W Homans, 2005, Chembiochem : a European journal of chemical biology.

NMR spectroscopy tools for structure-aided drug design.

S. Homans, 2004, Angewandte Chemie.

Solution structure of the glycosylphosphatidylinositol membrane anchor glycan of Trypanosoma brucei variant surface glycoprotein.

R. Dwek, M. Ferguson, T. Rademacher, 1989, Biochemistry.

Immunoglobulin G as a glycoprotein.

R. Dwek, T. Rademacher, R. Parekh, 1986, Biochemical Society symposium.

Residual dipolar couplings as new conformational restraints in isotopically 13C‐enriched oligosaccharides

S. Homans, G. Kiddle, 1998, FEBS letters.

Improved Resolution and Sensitivity of Triple-Resonance NMR Methods for the Structural Analysis of Proteins by Use of a Backbone-Labeling Strategy

S. Homans, Jonathan M. Brown, P. Coughlin, 1999 .

Dissecting the cholera toxin-ganglioside GM1 interaction by isothermal titration calorimetry.

S. Homans, W Bruce Turnbull, W. Turnbull, 2004, Journal of the American Chemical Society.

Probing dynamics within amyloid fibrils using a novel capping method.

S. Radford, S. Homans, W. Xue, 2009, Angewandte Chemie.

Conformation and dynamics of oligosaccharides in solution.

S. Homans, S W Homans, 1993, Glycobiology.

Chemoenzymatic synthesis of GM3, Lewis x and sialyl Lewis x oligosaccharides in 13C-enriched form

R. Field, S. Homans, S. Schenkman, 1997 .

Solution conformations of N-linked oligosaccharides.

R. Dwek, T. Rademacher, S. Homans, 1987, Biochemistry.

Residual 2H quadrupolar couplings in weakly aligned carbohydrates.

S. Homans, A. Kjellberg, 2001, Journal of magnetic resonance.

Synthesis of prospective disaccharide ligands for Escherichia coli O157 verotoxin

R. Field, S. Homans, C. Bernlind, 2009 .

New conformational constraints in isotopically (13C) enriched oligosaccharides.

R. Field, S. Homans, R. Harris, 1998, Glycobiology.

Three-dimensional heteronuclear NMR techniques for assignment and conformational analysis using exchangeable protons in uniformly 13C-enriched oligosaccharides

T. Rutherford, S. Homans, R. Harris, 1997, Journal of biomolecular NMR.

Thermodynamics of binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the major urinary protein.

G. Bodenhausen, S. Phillips, S. Homans, 2004, Journal of the American Chemical Society.

The β1 → 2‐d‐xylose and α1 → 3‐l‐fucose substituted N‐linked oligosaccharides from Erythrina cristagalli lectin

R. Dwek, T. Rademacher, S. Homans, 1987 .

Tertiary structure in N-linked oligosaccharides.

R. Dwek, T. Rademacher, S. Homans, 1987, Biochemistry.

Conformational transitions in N-linked oligosaccharides.

W. Richards, R. Dwek, T. Rademacher, 1986, Biochemistry.

Complete structure of the glycosyl phosphatidylinositol membrane anchor of rat brain Thy-1 glycoprotein

R. Dwek, M. Ferguson, T. Rademacher, 1988, Nature.

Simplification of COSY spectra of oligosaccharides by application of a 2D analog of 3D HOHAHA-COSY

S. Homans, 1990 .

Homonuclear three-dimensional NMR methods for the complete assignment of proton NMR spectra of oligosaccharides—application to Galβ1–4(Fucα1–3)GlcNAcβ1–3Galβ1-4Glc

S. Homans, 1992 .

The β1 → 2‐d‐xylose and α1 → 3‐l‐fucose substituted N‐linked oligosaccharides from Erythrina cristagalli lectin

R. Dwek, T. Rademacher, S. Homans, 1987 .

A Unique Multifucosylated −3GalNAc14GlcNAc13Gal1- Motif Constitutes the Repeating Unit of the Complex O-Glycans Derived from the Cercarial Glycocalyx of Schistosoma mansoni (*)

K. Khoo, A. Dell, H. Morris, 1995, The Journal of Biological Chemistry.

Refined structure of the lipophosphoglycan of Leishmania donovani.

M. Ferguson, J. Thomas-Oates, S. Homans, 1992, The Journal of biological chemistry.

Structures of the glycoinositolphospholipids from Leishmania major. A family of novel galactofuranose-containing glycolipids.

A. Bacic, J. Thomas-Oates, A. Dell, 1990, The Journal of biological chemistry.

5 nanosecond molecular dynamics and NMR study of conformational transitions in the sialyl-Lewis X antigen.

P. Simpson, T. Rutherford, S. Homans, 1994, Glycobiology.

Restrained vs free dynamics simulations of oligosaccharides: application to solution dynamics of biantennary and bisected biantennary N-linked glycans.

T. Rutherford, S. Homans, T. J. Rutherford, 1994, Biochemistry.

Solution structure and dynamics of a glycoinositol phospholipid (GIPL‐6) from Leishmania major

S. Homans, M. McConville, C. T. Weller, 1994, Biopolymers.

Characterization of the extent of internal motions in oligosaccharides.

T. Rutherford, S. Homans, C. T. Weller, 1993, Biochemistry.

Application of restrained minimization, simulated annealing and molecular dynamics simulations for the conformational analysis of oligosaccharides.

S. Homans, M. Forster, 1992, Glycobiology.

Oligosaccharide conformations: Application of NMR and energy calculations

S. Homans, 1991 .

Structure of the lipophosphoglycan from Leishmania major.

M. Ferguson, J. Thomas-Oates, S. Homans, 1990, The Journal of biological chemistry.

Parasite glycoconjugates: towards the exploitation of their structure

M. Ferguson, S. Homans, STEVEN W. HOMANS, 1988, Parasite immunology.

The use of two-dimensional correlated spectroscopy to obtain new assignments in the high-resolution 1H nuclear magnetic resonance spectrum of the biantennary complex oligosaccharide isolated from human serum transferrin by hydrazinolysis.

R. Dwek, T. Rademacher, S. Homans, 1983, Biochimica et biophysica acta.

Structure of the glycosyl-phosphatidylinositol membrane anchor of the Leishmania major promastigote surface protease.

M. Ferguson, S. Homans, M. McConville, 1990, The Journal of biological chemistry.

Structural and conformational analysis of glycan moieties in situ on isotopically 13C, 15N-enriched recombinant human chorionic gonadotropin.

R. Canfield, J. Brown, S. Ramnarain, 1996, Biochemistry.

Influence of the extent of branching on solution conformations of complex oligosaccharides: a molecular dynamics and NMR study of a penta-antennary "bisected" N-glycan.

T. Rutherford, S. Homans, D. C. Neville, 1995, Biochemistry.

Conformational studies on the selectin and natural killer cell receptor ligands sulfo- and sialyl-lacto-N-fucopentaoses (SuLNFPII and SLNFPII) using NMR spectroscopy and molecular dynamics simulations. Comparisons with the nonacidic parent molecule LNFPII.

T. Frenkiel, S. Homans, T. Feizi, 1996, Biochemistry.

Observer: The structure of oligosaccharides in solution - a new application of high resolution proton NMR

S. Homans, 1983 .

Solution conformation of the biantennary N‐linked oligosaccharide of human serotransferrin using 1H NMR nuclear Overhauser effect measurements

R. Dwek, T. Rademacher, S. Homans, 1982, FEBS letters.

A novel 13C isotopic labelling strategy for probing the structure and dynamics of glycan chains in situ on glycoproteins.

S. Homans, R. Jefferis, A. Gilhespy-Muskett, 1994, Glycobiology.

Heteronuclear Overhauser effects in carbohydrates

S. Homans, G. Kiddle, R. Harris, 1998 .

Structure of a glycoconjugate in solution and in complex with an antibody Fv fragment.

R. Field, S. Homans, P. Davis, 1997, Glycobiology.

Abstracts of the 20th International Isotope Society (UK group) Symposium: Synthesis & Applications of Labelled Compounds 2011

Y. Li, S. Kitson, S. Baldwin, 2012 .

Synthesis of uniformly deuterated n-dodecyl-β-D-maltoside (d39-DDM) for solubilization of membrane proteins in TROSY NMR experiments.

S. Homans, P. Henderson, S. G. Patching, 2014, Journal of labelled compounds & radiopharmaceuticals.

Solution dynamics of the oligosaccharide moiety of ganglioside GM1: Comparison of solution conformations with the bound state conformation in association with cholera toxin B‐pentamer

S. Homans, J. Richardson, M. J. Milton, 1995, Journal of molecular recognition : JMR.

Localization of the binding site for the oligosaccharide moiety of Gb3 on verotoxin 1 using NMR residual dipolar coupling measurements.

S. Homans, G. Thompson, A. Donohue-Rolfe, 2000, Biochemistry.

Solution structure of the complex between the B-subunit homopentamer of verotoxin VT-1 from Escherichia coli and the trisaccharide moiety of globotriaosylceramide.

R. Field, S. Homans, A. Donohue-Rolfe, 1998, Biochemistry.

A method for the rapid assignment of 1H NMR spectra of oligosaccharides using homonuclear Hartmann-Hahn spectroscopy.

R. Dwek, T. Rademacher, S. Homans, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Large-scale millisecond intersubunit dynamics in the B subunit homopentamer of the toxin derived from Escherichia coli O157.

S. Homans, G. Thompson, P. Kitov, 2003, Journal of the American Chemical Society.

Probing carbohydrate-protein interactions by high-resolution NMR spectroscopy.

R. Field, S. Homans, J. Richardson, 1998, Advances in experimental medicine and biology.

A sugar aminoacid for the development of multivalent ligands for Escherichia coli 0157 verotoxin

R. Field, S. Homans, Darren Gibson, 2009 .

Solution Structure of the Complex between the B-Subunit Homopentamer of Verotoxin VT-1 from Escherichia coli and the Trisaccharide Moiety of Globotriaosylceramide†

R. Field, S. Homans, A. Donohue-Rolfe, 1998 .

Structure-Guided Design Affirms Inhibitors of Hepatitis C Virus p7 as a Viable Class of Antivirals Targeting Virion Release

D. Rowlands, S. Homans, G. Thompson, 2013, Hepatology.

Purification and characterization of an extracellular phosphoglycan from Leishmania donovani.

M. Ferguson, S. Homans, M. McConville, 1992, The Journal of biological chemistry.

Thermodynamics of binding of D-galactose and deoxy derivatives thereof to the L-arabinose-binding protein.

S. Homans, A. Daranas, H. Shimizu, 2004, Journal of the American Chemical Society.

Contribution of ligand desolvation to binding thermodynamics in a ligand-protein interaction.

Agnieszka Bronowska, S. Homans, A. Bronowska, 2006, Angewandte Chemie.

Structural Studies on the Glycophospholipid Membrane Anchor of Trypanosoma Brucei Variant Surface Glycoprotein

R. Dwek, M. Ferguson, T. Rademacher, 1987 .

A simple, RNA-mediated allosteric switch controls the pathway to formation of a T=3 viral capsid.

Simona Francese, Peter G Stockley, Ottar Rolfsson, 2007, Journal of molecular biology.

Dissecting the fine details of assembly of a T=3 phage capsid

N. Ranson, P. Stockley, A. Smith, 2005 .

Nuclear magnetic resonance study of a deoxyoligonucleotide duplex containing a three base bulge.

D. Lilley, A. Murchie, S. Homans, 1993, Journal of molecular biology.

Solution conformation of biantennary complex type oligosaccharides

R. Dwek, T. Rademacher, S. Homans, 1983 .

Global Changes in Local Protein Dynamics Reduce the Entropic Cost of Carbohydrate Binding in the Arabinose-binding Protein

Agnieszka Bronowska, Steve W. Homans, S. Homans, 2007, Journal of molecular biology.

Origin of Heat Capacity Changes in a “Nonclassical” Hydrophobic Interaction

S. Phillips, S. Homans, C. Dennis, 2007, Chembiochem : a European journal of chemical biology.

Perspectives on NMR in drug discovery: a technique comes of age

Harald Schwalbe, Wolfgang Jahnke, Ernest Giralt, 2008, Nature Reviews Drug Discovery.

Ribosome clearance by FusB-type proteins mediates resistance to the antibiotic fusidic acid

M. Rodnina, W. Wintermeyer, S. Homans, 2012, Proceedings of the National Academy of Sciences.

Structures of glycosylphosphatidylinositol membrane anchors from Saccharomyces cerevisiae.

M. Ferguson, J. Thomas-Oates, S. Homans, 1993, The Journal of biological chemistry.

Complete structure of the glycan of lipopeptidophosphoglycan from Trypanosoma cruzi Epimastigotes.

M. Ferguson, J. Thomas-Oates, S. Homans, 1991, The Journal of biological chemistry.

Structure of the phosphosaccharide-inositol core of the Leishmania donovani lipophosphoglycan.

R. Dwek, M. Ferguson, T. Rademacher, 1989, The Journal of biological chemistry.

STABLE-ISOTOPE-ASSISTED NMR STUDIES ON 13C-ENRICHED SIALYL LEWISX IN SOLUTION AND BOUND TO E-SELECTIN

Beat Ernst, Robert A. Field, Steve W. Homans, 1999 .

Glycosyl-phosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the membrane.

R. Dwek, M. Ferguson, T. Rademacher, 1988, Science.

Chemical synthesis of 13C-labelled ganglioside Gb3 trisaccharide from [U-13C]-D-glucose

R. Field, S. Homans, Jonathan M. Brown, 1998 .

EVOLUTIONARY ASPECTS OF GPI METABOLISM IN KINETOPLASTID PARASITES

M. Ferguson, S. Homans, M. McConville, 1992 .

Evolutionary aspects of GPI metabolism in kinetoplastid parasites.

M. Ferguson, S. Homans, M. McConville, 1991, Cell biology international reports.

Identification of the 5-methylthiopentosyl substituent in Mycobacterium tuberculosis lipoarabinomannan.

S. Homans, D. Chatterjee, A. Treumann, 2004, Angewandte Chemie.

Comparison of Entropic Contributions to Binding in a “Hydrophilic” versus “Hydrophobic” Ligand−Protein Interaction

Agnieszka Bronowska, Steve W. Homans, S. Homans, 2010, Journal of the American Chemical Society.

Derivation of the Bound-State Conformation of a Ligand in a Weakly Aligned Ligand−Protein Complex

S. Homans, H. Shimizu, ‡. A. A. Donohue-Rolfe, 1999 .

5-Methylthiopentose: a new substituent on lipoarabinomannan in Mycobacterium tuberculosis.

S. Homans, A. Ashcroft, P. Derrick, 2002, Journal of molecular biology.

Localization of the Binding Site for the Oligosaccharide Moiety of Gb3 on Verotoxin 1 Using NMR Residual Dipolar Coupling Measurements

S. Homans, G. Thompson, A. Donohue-Rolfe, 2000 .

Solution structure of the lipophosphoglycan of Leishmania donovani.

S. Homans, S. Turco, A. Mehlert, 1992, Biochemistry.

Structure of the major carbohydrate fragment of the Leishmania donovani lipophosphoglycan.

R. Dwek, T. Rademacher, S. Homans, 1987, Biochemistry.

Structure of Leishmania mexicana lipophosphoglycan.

M. Ferguson, J. Thomas-Oates, S. Homans, 1992, The Journal of biological chemistry.

Identification of the defect in lipophosphoglycan biosynthesis in a non-pathogenic strain of Leishmania major.

S. Homans, M. McConville, 1992, The Journal of biological chemistry.

Glycosyl-phosphatidylinositol molecules of the parasite and the host

J. S. Brimacombe, M. Ferguson, R. Field, 1994, Parasitology.

The Architecture of GPI Anchor Glycans

S. Homans, 川口吉太郎, 1990 .

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

S. Radford, S. Homans, W. Xue, 2008, Proceedings of the National Academy of Sciences.

Poxvirus K7 protein adopts a Bcl-2 fold: biochemical mapping of its interactions with human DEAD box RNA helicase DDX3.

A. Bowie, S. Homans, G. Thompson, 2009, Journal of molecular biology.

Conformational Conversion during Amyloid Formation at Atomic Resolution

S. Radford, S. Homans, G. Thompson, 2011, Molecular cell.

Fibril Growth Kinetics Reveal a Region of β2-microglobulin Important for Nucleation and Elongation of Aggregation

S. Radford, S. Homans, Katy E. Routledge, 2008, Journal of molecular biology.

Amyloid formation under physiological conditions proceeds via a native-like folding intermediate

M. J. Parker, Sheena E Radford, S. Radford, 2006, Nature Structural &Molecular Biology.

Fibril Fragmentation Enhances Amyloid Cytotoxicity*♦

S. Radford, Walraj S. Gosal, S. Homans, 2009, The Journal of Biological Chemistry.

The glycosylphosphatidylinositol membrane anchor of Trypanosoma brucei variant surface glycoprotein.

R. Dwek, M. Ferguson, T. Rademacher, 1988, Biochemical Society transactions.

Van der Waals interactions dominate ligand-protein association in a protein binding site occluded from solvent water.

Charles A Laughton, Daniel J. Warner, Daniel J Warner, 2005, Journal of the American Chemical Society.

Solution structure of antifreeze glycopeptides

S. Homans, A. Devries, S. B. Parker, 1985 .

The membrane attachment of the variant surface glycoprotein coat of Trypanosoma brucei

S. Homans, Michael A. J. Ferguson, 1989 .

Evidence of chemical exchange in recombinant Major Urinary Protein and quenching thereof upon pheromone binding

G. Bodenhausen, S. Homans, C. Perazzolo, 2007, Journal of biomolecular NMR.

Dynamics and Thermodynamics of Ligand–Protein Interactions

S. W. Homans, S. Homans, 2006 .

Effects of Protein–pheromone Complexation on Correlated Chemical Shift Modulations

K. Loth, G. Bodenhausen, S. Homans, 2005, Journal of biomolecular NMR.

Chapter 3 3D Structure 2. Three Dimensional Structure of Oligosaccharides Explored by NMR and Computer Calculations

S. W. Homans, S. Homans, 1995 .

RNA packing specificity and folding during assembly of the bacteriophage MS2.

Ó. Rolfsson, N. Ranson, P. Stockley, 2008, Computational and mathematical methods in medicine.

Hadamard NMR spectroscopy for relaxation measurements of large (>35 kDa) proteins

S. Homans, A. Berry, B. Burnley, 2007, Journal of biomolecular NMR.

Structural properties of an amyloid precursor of β2-microglobulin

S. Radford, S. Homans, A. Kalverda, 2002, Nature Structural Biology.

Structure of the glycosyl-phosphatidylinositol membrane anchor of acetylcholinesterase from the electric organ of the electric-fish, Torpedo californica.

M. Ferguson, I. Silman, S. Homans, 1993, The Biochemical journal.

Solution structure of the carbohydrate-binding B-subunit homopentamer of verotoxin VT-1 from E. coli

S. Homans, J. Richardson, A. Donohue-Rolfe, 1997, Nature Structural Biology.

Dynamics in the unfolded state of beta2-microglobulin studied by NMR.

S. Radford, S. Homans, Geoffrey W. Platt, 2005, Journal of molecular biology.

Structure and dynamics in oligomannose-type oligosaccharides.

R. Dwek, A. Pastore, T. Rademacher, 1987, Biochemistry.

Ligand binding to distinct states diverts aggregation of an amyloid-forming protein

S. Radford, S. Homans, A. Ashcroft, 2011, Nature chemical biology.

A Dictionary of Concepts in NMR

S. W. Homans, S. Homans, 1990 .

Optimization of tether length in nonglycosidically linked bivalent ligands that target sites 2 and 1 of a Shiga-like toxin.

S. Homans, P. Kitov, D. Bundle, 2003, Journal of the American Chemical Society.

The analysis of coupling networks in a complex oligosaccharide mixture derived from the Fc region of rabbit immunoglobulin G using 1H-1H correlated NMR spectroscopy combined with double quantum NMR spectroscopy.

R. Dwek, T. Rademacher, S. Homans, 1984, Biochimica et biophysica acta.

Oligosaccharides and recognition--a 'shape' problem probed by n.m.r. and molecular modelling.

T. Rutherford, S. Homans, 1993, Biochemical Society transactions.

Amyloid fibril length distribution quantified by atomic force microscopy single-particle image analysis

S. Radford, S. Homans, W. Xue, 2009, Protein engineering, design & selection : PEDS.

Water, water everywhere--except where it matters?

S. Homans, Steve W Homans, 2007, Drug discovery today.

Residual ligand entropy in the binding of p-substituted benzenesulfonamide ligands to bovine carbonic anhydrase II.

Agnieszka Bronowska, S. Homans, S. Warriner, 2008, Journal of the American Chemical Society.

Strong solute-solute dispersive interactions in a protein-ligand complex.

Charles A Laughton, S. Phillips, S. Homans, 2005, Journal of the American Chemical Society.

A molecular mechanical force field for the conformational analysis of oligosaccharides: comparison of theoretical and crystal structures of Man alpha 1-3Man beta 1-4GlcNAc.

S. Homans, S W Homans, 1990, Biochemistry.

Sequence analysis of N-linked oligosaccharides derived from glycoproteins and glycopeptides.

S. Homans, 2007, Journal of chemical technology and biotechnology.

TROSY NMR with a 52 kDa sugar transport protein and the binding of a small-molecule inhibitor

S. Homans, P. Henderson, S. G. Patching, 2014, Molecular membrane biology.

Multiple-step relayed correlation spectroscopy: sequential resonance assignments in oligosaccharides.

R. Dwek, T. Rademacher, S. Homans, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

S. Radford, S. Homans, Wei-Feng Xue, 2008, Proceedings of the National Academy of Sciences.

Synthesis of uniformly deuterated n-dodecyl-β-D-maltoside (d39-DDM) for solubilization of membrane proteins in TROSY NMR experiments.

S. Homans, P. Henderson, S. G. Patching, 2014, Journal of labelled compounds & radiopharmaceuticals.

Global Changes in Local Protein Dynamics Reduce the Entropic Cost of Carbohydrate Binding in the Arabinose-binding Protein

S. Homans, A. Bronowska, C. MacRaild, 2007, Journal of molecular biology.

Structural properties of an amyloid precursor of beta(2)-microglobulin.

S. Radford, S. Homans, A. Kalverda, 2002, Nature structural biology.

Determination of protein global folds using backbone residual dipolar coupling and long-range NOE restraints

S. Homans, Jonathan M. Brown, Alexander W Giesen, 2003, Journal of biomolecular NMR.

1H-filtered correlation experiments for assignment and determination of coupling constants in backbone labelled proteins

S. Homans, S. M. Sullivan, Jonathan M. Brown, 2002, Journal of biomolecular NMR.

Systematic analysis of

S. Homans, S. Radford, Wei-Feng Xue, 2022 .

Thermodynamic penalty arising from burial of a ligand polar group within a hydrophobic pocket of a protein receptor.

Jirí Cerný, Agnieszka Bronowska, Jirí Vondrásek, 2006, Journal of molecular biology.

Methyl side-chain dynamics in proteins using selective enrichment with a single isotopomer.

S. Homans, J. Findlay, Jonathan M. Brown, 2003, Journal of the American Chemical Society.