D. S. Pilch

发表

Nucleic acid hybridization: triplex stability and energetics.

K. Breslauer, G. Plum, D. S. Pilch, 1995, Annual review of biophysics and biomolecular structure.

Thermodynamics of aminoglycoside-rRNA recognition: the binding of neomycin-class aminoglycosides to the A site of 16S rRNA.

D. S. Pilch, M. Kaul, 2002, Biochemistry.

TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus

M. Weinstein, E. LaVoie, D. S. Pilch, 2015, Antimicrobial Agents and Chemotherapy.

Inhibition of RND-type efflux pumps confers the FtsZ-directed prodrug TXY436 with activity against Gram-negative bacteria.

E. LaVoie, D. S. Pilch, M. Kaul, 2014, Biochemical pharmacology.

Antimicrobial activity of various 4- and 5-substituted 1-phenylnaphthalenes.

E. LaVoie, D. S. Pilch, Songfeng Lu, 2013, European journal of medicinal chemistry.

An FtsZ-Targeting Prodrug with Oral Antistaphylococcal Efficacy In Vivo

E. LaVoie, D. S. Pilch, M. Kaul, 2013, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics and in vivo antistaphylococcal efficacy of TXY541, a 1-methylpiperidine-4-carboxamide prodrug of PC190723.

E. LaVoie, D. S. Pilch, M. Kaul, 2013, Biochemical pharmacology.

Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines.

E. LaVoie, D. S. Pilch, M. Kaul, 2013, Bioorganic & medicinal chemistry letters.

Substituted 1,6-diphenylnaphthalenes as FtsZ-targeting antibacterial agents.

E. LaVoie, D. S. Pilch, M. Kaul, 2013, Bioorganic & medicinal chemistry letters.

Antibacterial activity of substituted dibenzo[a,g]quinolizin-7-ium derivatives.

E. LaVoie, D. S. Pilch, Songfeng Lu, 2012, Bioorganic & medicinal chemistry letters.

3-Phenyl substituted 6,7-dimethoxyisoquinoline derivatives as FtsZ-targeting antibacterial agents.

E. LaVoie, D. S. Pilch, M. Kaul, 2012, Bioorganic & medicinal chemistry.

G-quadruplexes induce apoptosis in tumor cells.

Chao-Po Lin, D. S. Pilch, C. M. Barbieri, 2006, Cancer research.

Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations.

J. Schacht, D. S. Pilch, V. Belakhov, 2009, Journal of medicinal chemistry.

Structural analysis of the (dA)10.2(dT)10 triple helix.

R. Shafer, C. Levenson, D. S. Pilch, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Berenil [1,3-bis(4'-amidinophenyl)triazene] binding to DNA duplexes and to a RNA duplex: evidence for both intercalative and minor groove binding properties.

K. Breslauer, G. Plum, D. S. Pilch, 1995, Biochemistry.

TXA497 as a topical antibacterial agent: comparative antistaphylococcal, skin deposition, and skin permeation studies with mupirocin.

E. LaVoie, D. S. Pilch, M. Kaul, 2014, International journal of pharmaceutics.

DNA sequence context modulates the impact of a cisplatin 1,2-d(GpG) intrastrand cross-link on the conformational and thermodynamic properties of duplex DNA.

S. Lippard, K. Breslauer, D. S. Pilch, 2000, Journal of molecular biology.

A G-quadruplex Stabilizer Induces M-phase Cell Cycle Arrest*

E. LaVoie, J. E. Rice, Chao-Po Lin, 2009, The Journal of Biological Chemistry.

Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds.

E. LaVoie, J. E. Rice, D. S. Pilch, 2008, Biochimie.

Self-association and DNA-binding properties of two triple helix-specific ligands: comparison of a benzo[e]pyridoindole and a benzo[g]pyridoindole

D. S. Pilch, C. Nguyen, Jian-sheng Sun, 1993 .

Defining the Molecular Forces That Determine the Impact of Neomycin on Bacterial Protein Synthesis: Importance of the 2′-Amino Functionality

T. Hermann, D. S. Pilch, C. M. Barbieri, 2007, Antimicrobial Agents and Chemotherapy.

Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity.

E. LaVoie, J. E. Rice, D. S. Pilch, 2010, Bioorganic & medicinal chemistry letters.

Novel MreB inhibitors with antibacterial activity against Gram (-) bacteria

E. LaVoie, D. S. Pilch, Yanlu Cao, 2022, Medicinal Chemistry Research.

A Spectrophotometric Study of the pH‐Dependent and DNA Binding Properties of Topotecan

D. S. Pilch, S. E. Miller, Steven E. Miller, 2000, Annals of the New York Academy of Sciences.

Antibacterial activity of substituted 5-methylbenzo[c]phenanthridinium derivatives.

E. LaVoie, D. S. Pilch, M. Kaul, 2012, Bioorganic & medicinal chemistry letters.

A terbenzimidazole that preferentially binds and conformationally alters structurally distinct DNA duplex domains: a potential mechanism for topoisomerase I poisoning.

Z. Xu, Q. Sun, E. LaVoie, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Binding of a hairpin polyamide in the minor groove of DNA: sequence-specific enthalpic discrimination.

P. Dervan, K. Breslauer, S. Law, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Influence of cisplatin intrastrand crosslinking on the conformation, thermal stability, and energetics of a 20-mer DNA duplex.

S. Lippard, K. Breslauer, D. S. Pilch, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Macrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents.

E. LaVoie, J. E. Rice, D. S. Pilch, 2010, Journal of medicinal chemistry.

5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones and related compounds as TOP1-targeting agents: influence of structure on the ternary cleavable complex formation.

E. LaVoie, D. S. Pilch, J. Kerrigan, 2003, Bioorganic & medicinal chemistry letters.

A structural model for the ternary cleavable complex formed between human topoisomerase I, DNA, and camptothecin.

D. S. Pilch, J. Kerrigan, John E. Kerrigan, 2001, Biochemistry.

Structural Flexibility of an Inhibitor Overcomes Drug Resistance Mutations in Staphylococcus aureus FtsZ.

E. LaVoie, D. S. Pilch, E. Mizohata, 2017, ACS chemical biology.

Lysinyl macrocyclic hexaoxazoles: synthesis and selective G-quadruplex stabilizing properties.

E. LaVoie, J. E. Rice, D. S. Pilch, 2008, Bioorganic & medicinal chemistry letters.

Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles.

E. LaVoie, J. E. Rice, D. S. Pilch, 2006, Bioorganic & medicinal chemistry letters.

Ring-closing metathesis for the synthesis of a highly G-quadruplex selective macrocyclic hexaoxazole having enhanced cytotoxic potency.

E. LaVoie, J. E. Rice, D. S. Pilch, 2008, Bioorganic & medicinal chemistry letters.

The thermodynamics of DNA structures that contain lesions or guanine tetrads.

K. Breslauer, G. Plum, D. S. Pilch, 1995, Current opinion in structural biology.

Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA

A. R. Srinivasan, E. LaVoie, J. E. Rice, 2007, Nucleic acids research.

Human topoisomerase I poisoning by protoberberines: potential roles for both drug-DNA and drug-enzyme interactions.

A. R. Srinivasan, W. Olson, L. Liu, 2000, Biochemistry.

Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs.

A. R. Srinivasan, W. Olson, C. Yu, 1997, Biochemistry.

Defining the basis for the specificity of aminoglycoside-rRNA recognition: a comparative study of drug binding to the A sites of Escherichia coli and human rRNA.

D. S. Pilch, C. M. Barbieri, M. Kaul, 2005, Journal of molecular biology.

Ligand-induced formation of nucleic acid triple helices.

K. Breslauer, D. S. Pilch, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of a triple helix-specific ligand. BePI (3-methoxy-7H-8-methyl-11- [(3'-amino)propylamino]-benzo[e]pyrido[4,3-b]indole) intercalates into both double-helical and triple-helical DNA.

M. Waring, M. Rougée, D. S. Pilch, 1993, Journal of molecular biology.

Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistant Staphylococcus aureus

E. LaVoie, D. S. Pilch, M. Kaul, 2022, Medicinal Chemistry Research.

Structure-activity relationships of potentiators of the antibiotic activity of clarithromycin against Escherichia coli.

E. LaVoie, D. S. Pilch, M. Kaul, 2019, European journal of medicinal chemistry.

Advances in the structural studies of antibiotic potentiators against Escherichia coli.

E. LaVoie, D. S. Pilch, M. Kaul, 2019, Bioorganic & medicinal chemistry.

Modulation of nucleic acid structure by ligand binding: induction of a DNA.RNA.DNA hybrid triplex by DAPI intercalation.

A. R. Srinivasan, W. Olson, Z. Xu, 1997, Bioorganic & medicinal chemistry.

Aminoglycoside complexation with a DNA.RNA hybrid duplex: the thermodynamics of recognition and inhibition of RNA processing enzymes.

Roger A. Jones, B. Gaffney, D. S. Pilch, 2003, Journal of the American Chemical Society.

Molecular determinants of antibiotic recognition and resistance by aminoglycoside phosphotransferase (3')-IIIa: a calorimetric and mutational analysis.

A. R. Srinivasan, D. S. Pilch, C. M. Barbieri, 2007, Journal of molecular biology.

Complete thermodynamic characterization of the multiple protonation equilibria of the aminoglycoside antibiotic paromomycin: a calorimetric and natural abundance 15N NMR study.

D. S. Pilch, C. M. Barbieri, 2006, Biophysical journal.

Aminoglycoside-induced reduction in nucleotide mobility at the ribosomal RNA A-site as a potentially key determinant of antibacterial activity.

D. S. Pilch, C. M. Barbieri, M. Kaul, 2006, Journal of the American Chemical Society.

Coupling of drug protonation to the specific binding of aminoglycosides to the A site of 16 S rRNA: elucidation of the number of drug amino groups involved and their identities.

John E Kerrigan, D. S. Pilch, C. M. Barbieri, 2003, Journal of molecular biology.

Structure, stability, and thermodynamics of a short intermolecular purine-purine-pyrimidine triple helix.

R. Shafer, C. Levenson, D. S. Pilch, 1991, Biochemistry.

Thermodynamics of triple helix formation: spectrophotometric studies on the d(A)10.2d(T)10 and d(C+3T4C+3).d(G3A4G3).d(C3T4C3) triple helices.

R. Shafer, D. S. Pilch, R. Brousseau, 1990, Nucleic acids research.

Stability and Energetics

G. Plum, D. S. Pilch, S. Singleton, 1995 .

Differential Selectivity of Natural and Synthetic Aminoglycosides towards the Eukaryotic and Prokaryotic Decoding A Sites

E. Westhof, J. Kondo, D. S. Pilch, 2007, Chembiochem : a European journal of chemical biology.

Use of 2-aminopurine as a fluorescent tool for characterizing antibiotic recognition of the bacterial rRNA A-site.

D. S. Pilch, C. M. Barbieri, M. Kaul, 2007, Tetrahedron.

Thermodynamics of aminoglycoside-rRNA recognition.

D. S. Pilch, C. M. Barbieri, J. Kerrigan, 2003, Biopolymers.

Berenil binding to higher ordered nucleic acid structures: complexation with a DNA and RNA triple helix.

K. Breslauer, D. S. Pilch, M. A. Kirolos, 1995, Biochemistry.

Aminoglycoside binding in the major groove of duplex RNA: the thermodynamic and electrostatic forces that govern recognition.

R. Abagyan, W. Olson, V. Katritch, 2000, Journal of molecular biology.

Acylpyrazoline-Based Third-Generation Selective Antichlamydial Compounds with Enhanced Potency

H. Fan, John Gilleran, D. S. Pilch, 2023, ACS omega.

A bactericidal guanidinomethyl biaryl that alters the dynamics of bacterial FtsZ polymerization.

S. Tuske, E. Arnold, E. LaVoie, 2012, Journal of medicinal chemistry.

Impact of FtsZ Inhibition on the Localization of the Penicillin Binding Proteins in Methicillin-Resistant Staphylococcus aureus

D. S. Pilch, J. Boyd, Hassan M Al-Tameemi, 2021, Journal of bacteriology.

2"-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons.

A. Liu, L. Liu, E. LaVoie, 2000, Bioorganic & medicinal chemistry.

Topoisomerase I-mediated DNA cleavage induced by the minor groove-directed binding of bibenzimidazoles to a distal site.

D. S. Pilch, Q. Khan, 2007, Journal of molecular biology.

Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors.

A. Liu, L. Liu, E. LaVoie, 2000, Bioorganic & medicinal chemistry letters.

Combining the FtsZ-Targeting Prodrug TXA709 and the Cephalosporin Cefdinir Confers Synergy and Reduces the Frequency of Resistance in Methicillin-Resistant Staphylococcus aureus

E. LaVoie, D. S. Pilch, M. Kaul, 2016, Antimicrobial Agents and Chemotherapy.

Fluorescence-based approach for detecting and characterizing antibiotic-induced conformational changes in ribosomal RNA: comparing aminoglycoside binding to prokaryotic and eukaryotic ribosomal RNA sequences.

D. S. Pilch, C. M. Barbieri, M. Kaul, 2004, Journal of the American Chemical Society.

Enterococcal and streptococcal resistance to PC190723 and related compounds: molecular insights from a FtsZ mutational analysis.

S. Tuske, E. Arnold, E. LaVoie, 2013, Biochimie.

TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens

J. Y. Roberge, E. LaVoie, D. S. Pilch, 2022, Antibiotics.

Macrocyclic Pyridyl Polyoxazoles: Structure-Activity Studies of the Aminoalkyl Side-Chain on G-Quadruplex Stabilization and Cytotoxic Activity

E. LaVoie, J. E. Rice, D. S. Pilch, 2013, Molecules.

Differential poisoning of topoisomerases by menogaril and nogalamycin dictated by the minor groove-binding nogalose sugar.

B. Gatto, C. Yu, A. Liu, 1997, Biochemistry.

Structural and Thermodynamic Studies of d(C3T4C3) in Acid Solution: Evidence for Formation of the Hemiprotonated CH+·C Base Pair

R. Shafer, D. S. Pilch, 1993 .

Structural and Antibacterial Characterization of a New Benzamide FtsZ Inhibitor with Superior Bactericidal Activity and In Vivo Efficacy Against Multidrug-Resistant Staphylococcus aureus.

E. LaVoie, D. S. Pilch, M. Kaul, 2023, ACS Chemical Biology.

Structure-Guided Design of a Fluorescent Probe for the Visualization of FtsZ in Clinically Important Gram-Positive and Gram-Negative Bacterial Pathogens

E. LaVoie, D. S. Pilch, J. Boyd, 2019, Scientific Reports.

Pentamidine inhibits catalytic activity of group I intron Ca.LSU by altering RNA folding

Yi Zhang, Zhijie Li, Daniel S. Pilch, 2002, Nucleic Acids Res..

Macrocyclic biphenyl tetraoxazoles: synthesis, evaluation as G-quadruplex stabilizers and cytotoxic activity.

E. LaVoie, J. E. Rice, D. S. Pilch, 2013, Bioorganic & medicinal chemistry.

β-Lactam Antibiotics with a High Affinity for PBP2 Act Synergistically with the FtsZ-Targeting Agent TXA707 against Methicillin-Resistant Staphylococcus aureus

E. LaVoie, D. S. Pilch, M. Kaul, 2017, Antimicrobial Agents and Chemotherapy.

Site-specific topoisomerase I-mediated DNA cleavage induced by nogalamycin: a potential role of ligand-induced DNA bending at a distal site.

L. Liu, D. S. Pilch, S. Sim, 2000, Biochemistry.

Calorimetry of Nucleic Acids

M. Egli, D. S. Pilch, E. Rozners, 2000, Current protocols in nucleic acid chemistry.

Abstract C76: Oxazole‐containing macrocyles as selective G‐quadruplex stabilizers

E. LaVoie, J. E. Rice, D. S. Pilch, 2009 .

The thermodynamics of polyamide-DNA recognition: hairpin polyamide binding in the minor groove of duplex DNA.

P. Dervan, K. Breslauer, D. S. Pilch, 1999, Biochemistry.

Drug targeting of HIV-1 RNA.DNA hybrid structures: thermodynamics of recognition and impact on reverse transcriptase-mediated ribonuclease H activity and viral replication.

Roger A. Jones, B. Gaffney, D. S. Pilch, 2004, Biochemistry.

Ribosomal RNA recognition by aminoglycoside antibiotics

D. S. Pilch, C. M. Barbieri, M. Kaul, 2005 .

Deciphering the origins of observed heat capacity changes for aminoglycoside binding to prokaryotic and eukaryotic ribosomal RNA a-sites: a calorimetric, computational, and osmotic stress study.

A. R. Srinivasan, D. S. Pilch, C. M. Barbieri, 2004, Journal of the American Chemical Society.