S. Beaucage

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Current Protocols in Nucleic Acid Chemistry

S. Beaucage, Serge L. Beaucage, 1999 .

CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma.

S. Beaucage, D. Klinman, A. Krieg, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis

M. Caruthers, S. Beaucage, 1981 .

Chemical synthesis of deoxyoligonucleotides by the phosphoramidite method.

M. Caruthers, L. Mcbride, S. Beaucage, 1987, Methods in enzymology.

Nucleotide chemistry. 16. Amidine protecting groups for oligonucleotide synthesis

R. Kierzek, M. Caruthers, L. Mcbride, 1986 .

A High‐Throughput Process for the Solid‐Phase Purification of Synthetic DNA Sequences

S. Beaucage, A. Grajkowski, J. Cieślak, 2017, Current protocols in nucleic acid chemistry.

Alterations in the HLA-B*57:01 Immunopeptidome by Flucloxacillin and Immunogenicity of Drug-Haptenated Peptides

Zhihua Li, D. Margulies, W. Hildebrand, 2021, Frontiers in Immunology.

The Functionalization of Oligonucleotides Via Phosphoramidite Derivatives

S. Beaucage, R. Iyer, 1993 .

Assessment of the cellular internalization of thermolytic phosphorothioate DNA oligonucleotide prodrugs.

S. Beaucage, K. Takeda, C. Tami, 2013, Bioorganic & medicinal chemistry.

3H-1,2-Benzodithiole-3-one 1,1-dioxide as an improved sulfurizing reagent in the solid-phase synthesis of oligodeoxyribonucleoside phosphorothioates

S. Beaucage, R. Iyer, W. Egan, 1990 .

Permanent or reversible conjugation of 2′-O- or 5′-O-aminooxymethylated nucleosides with functional groups as a convenient and efficient approach to the modification of RNA and DNA sequences

S. Beaucage, A. Gapeev, A. Grajkowski, 2011, Nucleic acids research.

Convenient and Efficient Approach to the Permanent or Reversible Conjugation of RNA and DNA Sequences with Functional Groups

S. Beaucage, A. Grajkowski, J. Cieślak, 2012, Current protocols in nucleic acid chemistry.

Trans‐acting oligodeoxythymidine phosphorothioate triester reagents for transient transfection optimized and facilitated by a high‐throughput microbioreactor system

S. Lute, K. Brorson, S. Beaucage, 2018, Biotechnology and applied biochemistry.

Chemical synthesis and biological studies on mutated gene-control regions.

M. Caruthers, W. Mandecki, P. Dehaseth, 1983, Cold Spring Harbor Symposia on Quantitative Biology.

Biotinylation of a Propargylated Cyclic (3′‐5′) Diguanylic Acid and of Its Mono‐6‐Thioated Analog Under “Click” Conditions

C. Schindler, S. Beaucage, A. Grajkowski, 2013, Current protocols in nucleic acid chemistry.

A Novel Function of RNAs Arising From the Long Terminal Repeat of Human Endogenous Retrovirus 9 in Cell Cycle Arrest

E. Petricoin, Lai Xu, A. Elkahloun, 2012, Journal of Virology.

Solid-phase synthesis of siRNA oligonucleotides.

S. Beaucage, 2008, Current opinion in drug discovery & development.

Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach

S. Beaucage, Radhakrishman P. Iyer, 1992 .

CpG ODN D35 improves the response to abbreviated low-dose pentavalent antimonial treatment in non-human primate model of cutaneous leishmaniasis

B. Arana, F. Modabber, S. Beaucage, 2020, PLoS neglected tropical diseases.

Use of thermolytic protective groups to prevent G-tetrad formation in CpG ODN type D: structural studies and immunomodulatory activity in primates

S. Beaucage, M. Puig, D. Verthelyi, 2006, Nucleic acids research.

Inhibition of potentially anti-apoptotic proteins by antisense protein kinase C-alpha (Isis 3521) and antisense bcl-2 (G3139) phosphorothioate oligodeoxynucleotides: relationship to the decreased viability of T24 bladder and PC3 prostate cancer cells.

S. Beaucage, C. Stein, L. Benimetskaya, 2001, Molecular pharmacology.

Amphipathic trans-acting phosphorothioate DNA elements mediate the delivery of uncharged nucleic acid sequences in mammalian cells

S. Beaucage, D. Verthelyi, H. Jain, 2015 .

Structural evaluation of an amyloid fibril model using small-angle x-ray scattering

A. Badano, S. Beaucage, Ashwinkumar A. Bhirde, 2017, Physical biology.

An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes.

S. Beaucage, K. Nagaraju, D. Verthelyi, 2017, RSC advances.

A simple and efficient preparation of deoxynucleoside phosphoramidites in situ

S. Beaucage, 1984 .

Deoxyribonucleoside Cyclic N-Acylphosphoramidites as a New Class of Monomers for the Stereocontrolled Synthesis of Oligothymidylyl- and Oligodeoxycytidylyl- Phosphorothioates

S. Beaucage, A. Grajkowski, A. Wilk, 2000 .

The synthesis of specific ribonucleotides and unrelated phosphorylated biomolecules by the phosphoramidite method

S. Beaucage, R. Iyer, 1993 .

The 4-[N-Methyl-N-(2,2,2-trifluoroacetyl)amino]butyl Group as an Alternative to the 2-Cyanoethyl Group for Phosphate Protection in the Synthesis of Oligodeoxyribonucleotides

S. Beaucage, A. Grajkowski, A. Wilk, 1999 .

New chemical methods for synthesizing polynucleotides.

M. Caruthers, S. Beaucage, J. Efcavitch, 1980, Nucleic acids symposium series.

Time‐Dependent Thermocontrol of the Hydrophilic and Lipophilic Properties of DNA Oligonucleotide Prodrugs

S. Beaucage, A. Gapeev, A. Grajkowski, 2010, Current protocols in nucleic acid chemistry.

Recent Advances in the Chemical Synthesis of RNA

S. Beaucage, C. Reese, 2009, Current protocols in nucleic acid chemistry.

Use of Arabinonucleosides for Development and Implementation of a Novel 2′‐O‐Protecting Group for Efficient Solid‐Phase Synthesis and 2′‐O‐Deprotection of RNA Sequences

S. Beaucage, Mayumi Takahashi, A. Grajkowski, 2022, Current protocols.

Solid-Phase Purification of Synthetic DNA Sequences.

S. Beaucage, A. Grajkowski, J. Cieślak, 2016, The Journal of organic chemistry.

Strategies in the preparation of DNA oligonucleotide arrays for diagnostic applications.

S. Beaucage, 2001, Current medicinal chemistry.

Assessment of heat-sensitive thiophosphate protecting groups in the development of thermolytic DNA oligonucleotide prodrugs

Jon S. Kauffman, S. Beaucage, R. Duff, 2010 .

Stable inheritance of bacterial plasmids: practical considerations in the release of organisms into the environment.

S. Cohen, S. Beaucage, C. Miller, 1988, Basic life sciences.

An Improved Strategy for the Chemical Synthesis of 3′,5′‐Cyclic Diguanylic Acid

S. Beaucage, S. Srivastava, Mayumi Takahashi, 2019, Current protocols in nucleic acid chemistry.

An improved phosphoramidite approach for the chemical synthesis of 3′,5′-cyclic diguanylic acid

S. Beaucage, S. Srivastava, Mayumi Takahashi, 2019, Tetrahedron Letters.

A facile method for the removal of phosphate protecting groups in nucleotide synthesis

S. Beaucage, K. K. Ogilvie, D. Entwistle, 1976 .

Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach

S. Beaucage, Serge L. Beaucage, Radhakrishman P. Iyer, 1992 .

7.06 – Attachment of Reporter and Conjugate Groups to DNA

S. Beaucage, 1999 .

Stepwise Regeneration and Recovery of Deoxyribonucleoside Phosphoramidite Monomers During Solid-Phase Oligonucleotide Synthesis

S. Beaucage, K. Srinivasachar, Liang Zhou, 1994 .

Novel multiple 5'-amino-modified primer for DNA microarrays.

R. Puri, Jing Han, S. Beaucage, 2005, Genomics.

Synthetic Strategies and Parameters Involved in the Synthesis of Oligodeoxyribonucleotides According to the Phosphoramidite Method

M. Caruthers, S. Beaucage, 2000, Current protocols in nucleic acid chemistry.

Facile alkylation of purines, pyrimidines, nucleosides and nucleotides using tetrabutylammonium fluoride

S. Beaucage, M. F. Gillen, K. K. Ogilvie, 1978 .

The Synthesis of Modified Oligonucleotides by the Phosphoramidite Approach and Their Applications

S. Beaucage, R. Iyer, 1993 .

Oligodeoxyribonucleotides synthesis. Phosphoramidite approach.

S. Beaucage, 1993, Methods in molecular biology.

Assessment of 4-nitrogenated benzyloxymethyl groups for 2'-hydroxyl protection in solid-phase RNA synthesis.

Jon S. Kauffman, S. Beaucage, J. Lloyd, 2007, Organic letters.

Thermolytic 4-methylthio-1-butyl group for phosphate/thiophosphate protection in solid-phase synthesis of DNA oligonucleotides.

S. Beaucage, A. Grajkowski, J. Cieślak, 2004, The Journal of organic chemistry.

2-mercaptobenzothiazole--an improved reagent for the removal of methyl phosphate protecting groups from oligodeoxynucleotide phosphotriesters.

S. Beaucage, A. Andrus, 1988 .

SYNTHESIS OF (2-DEOXY-ALPHA - AND -BETA -D-ERYTHRO-PENTOFURANOSYL)(THYMIN-1-YL)ALKANES AND THEIR INCORPORATION INTO OLIGODEOXYRIBONUCLEOTIDES. EFFECT OF NUCLEOBASE-SUGAR LINKER FLEXIBILITY ON THE FORMATION OF DNA-DNA AND DNA- RNA HYBRIDS

S. Beaucage, L. Phillips, Glenn N. Gray, 1996 .

Fluoride ion-promoted transesterification in phosphate triesters

S. Beaucage, K. K. Ogilvie, 1976 .

Innovative 2'-O-Imino-2-propanoate-Protecting Group for Effective Solid-Phase Synthesis and 2'-O-Deprotection of RNA Sequences.

S. Beaucage, Mayumi Takahashi, A. Grajkowski, 2021, The Journal of organic chemistry.

2,2,5,5-tetramethylpyrrolidin-3-one-1-sulfinyl group for 5'-hydroxyl protection of deoxyribonucleoside phosphoramidites in the solid-phase preparation of DNA oligonucleotides.

S. Beaucage, V. Marchán, J. Cieślak, 2004, Journal of the American Chemical Society.

Thermolytic carbonates for potential 5'-hydroxyl protection of deoxyribonucleosides.

S. Beaucage, M. Chmielewski, V. Marchán, 2003, Journal of Organic Chemistry.

Hydroxyalkylated phosphoramidate, phosphoramidothioate and phosphorodiamidothioate derivatives as thiophosphate protecting groups in the development of thermolytic DNA prodrugs

S. Beaucage, A. Gapeev, A. Grajkowski, 2010 .

Thermolytic CpG-containing DNA oligonucleotides as potential immunotherapeutic prodrugs

S. Beaucage, S. Hess, D. Verthelyi, 2005, Nucleic acids research.

Thermolytic Carbonates for Potential 5′‐Hydroxyl Protection of Deoxyribonucleosides.

S. Beaucage, M. Chmielewski, V. Marchán, 2004 .

Conceptual “Heat‐Driven” Approach to the Synthesis of DNA Oligonucleotides on Microarrays

S. Beaucage, L. Phillips, V. Marchán, 2003, Annals of the New York Academy of Sciences.

The automated synthesis of sulfur-containing oligodeoxyribonucleotides using 3H-1,2-benzodithiol-3-one 1,1-dioxide as a sulfur-transfer reagent

S. Beaucage, R. Iyer, W. Egan, 1990 .

An efficient procedure for the solid phase tritylation of nucleosides and nucleotides

S. Beaucage, J. Rampal, Serge L. Beaucage, 1987 .

2‐Cyanoethyl Tetraisopropylphosphorodiamidite

S. Beaucage, 2003 .

A GENERAL TRANSESTERIFICATION METHOD FOR THE SYNTHESIS OF MIXED TRIALKYL PHOSPHATES

S. Beaucage, K. K. Ogilvie, N. Theriault, 1977 .

Chemical phosphorylation of deoxyribonucleosides and thermolytic DNA oligonucleotides.

S. Beaucage, A. Grajkowski, J. Cieślak, 2006, Current protocols in nucleic acid chemistry.

An efficient reagent for the phosphorylation of deoxyribonucleosides, DNA oligonucleotides, and their thermolytic analogues.

S. Beaucage, A. Grajkowski, J. Cieślak, 2005, Organic letters.

Amidine protecting groups for oligonucleotide synthesis

R. Kierzek, M. Caruthers, L. Mcbride, 1986 .

The Chemical Synthesis of DNA and RNA Oligonucleotides for Drug Development and Synthetic Biology Applications

S. Beaucage, H. Jain, 2016 .

Cleavage of oligodeoxyribonucleotides from controlled-pore glass supports and their rapid deprotection by gaseous amines.

N. Harindranath, E. E. Max, S. Beaucage, 1996, Nucleic acids research.

Synthesis of atom-specific nucleobase and ribose labeled uridine phosphoramidite for NMR analysis of large RNAs

S. Beaucage, T. K. Dayie, L. T. Olenginski, 2021, Monatshefte für Chemie - Chemical Monthly.

Alternating .alpha.,.beta.-oligothymidylates with alternating (3'.fwdarw.3')- and (5'.fwdarw.5')-internucleotidic phosphodiester linkages as models for antisense oligodeoxyribonucleotides

S. Beaucage, M. Koga, Michael F. Moore, 1991 .

Abstracts from the Third Annual NIH Symposium on Therapeutic Oligonucleotides

L. Neckers, S. Beaucage, Y. Cho‐Chung, 1999 .

[(2-Deoxy-α- and β-D-erythro-pentofuranosyl)thymin-1-YL] methane derivatives as potential conformational probes for altDNA oligonucleotides

S. Beaucage, L. Phillips, J. Boal, 1996 .

1-(2-Deoxy-α- and β-D-erythro-pentofuranosyl)-2-(thymin-1-yl)ethane derivatives as conformational probes for altDNA oligonucleotides

S. Beaucage, L. Phillips, J. Boal, 1995 .

2‐Cyanoethyl Diisopropylchlorophosphoramidite

S. Beaucage, 2002 .

Synthesis and Physicochemical Properties of Alternating .alpha.,.beta.-Oligodeoxyribonucleotides with Alternating (3'.fwdarw.3')- and (5'.fwdarw.5')-Internucleotidic Phosphodiester Linkages

S. Beaucage, A. Wilk, M. Koga, 1995 .

Release of DNA Oligonucleotides and Their Conjugates from Controlled‐Pore Glass Under Thermolytic Conditions

Jon S. Kauffman, S. Beaucage, R. Duff, 2008, Current protocols in nucleic acid chemistry.

Thermolytic release of covalently linked DNA oligonucleotides and their conjugates from controlled-pore glass at near neutral pH.

Jon S. Kauffman, S. Beaucage, R. Duff, 2008, Bioconjugate chemistry.

The 4‐Methylthio‐1‐Butyl Group for Phosphate/Thiophosphate Protection in Oligodeoxyribonucleotide Synthesis

S. Beaucage, A. Grajkowski, J. Cieślak, 2004, Current protocols in nucleic acid chemistry.

3‐(N‐tert‐Butylcarboxamido)‐1‐propyl and 4‐Oxopentyl Groups for Phosphate/Thiophosphate Protection in Oligodeoxyribonucleotide Synthesis

S. Beaucage, M. Chmielewski, L. Phillips, 2002, Current protocols in nucleic acid chemistry.

The 4-oxopentyl group as a labile phosphate/thiophosphate protecting group for synthetic oligodeoxyribonucleotides

S. Beaucage, M. Chmielewski, L. Phillips, 2001 .

The 2-(N-formyl-N-methyl)aminoethyl group as a potential phosphate/thiophosphate protecting group in solid-phase oligodeoxyribonucleotide synthesis.

S. Beaucage, M. Chmielewski, L. Phillips, 2001, Organic letters.

Fluoride ion catalyzed alkylation of purines, pyrimidines, nucleosides and nucleotides using alky halides.

S. Beaucage, M. Quilliam, M. F. Gillen, 1979, Nucleic acids research.

Fluoride ion catalyzed alkylation of nucleic acid derivatives using trialkyl phosphates, dialkyl sulfates and alkyl methanesulfonates.

S. Beaucage, M. F. Gillen, K. K. Ogilvie, 1979, Nucleic acids research.

Fluoride ion promoted deprotection and transesterification in nucleotide triesters.

S. Beaucage, K. K. Ogilvie, 1979, Nucleic acids research.

Synthesis of an Atom‐Specifically 2H/13C‐Labeled Uridine Ribonucleoside Phosphoramidite

S. Beaucage, T. K. Dayie, L. T. Olenginski, 2022, Current protocols.

3H‐1,2‐Benzodithiol‐3‐one 1,1‐dioxide

S. Beaucage, 2012 .

((2‐Deoxy‐α‐ and β‐D‐Erythro‐pentofuranosyl)thymin‐1‐yl) methane Derivatives as Potential Conformational Probes for altDNA Oligonucleotides.

S. Beaucage, L. Phillips, J. Boal, 1996 .

Large-Scale Preparation of the Sulfur-Transfer Reagent 3H-1,2- Benzodithiol-3-one 1,1-Dioxide.

S. Beaucage, L. Phillips, J. B. Regan, 1993 .

LARGE-SCALE PREPARATION OF THE SULFUR-TRANSFER REAGENT 3H-1,2-BENZODITHIOL-3-ONE 1,1-DIOXIDE

S. Beaucage, L. Phillips, J. B. Regan, 1992 .

Solid-phase synthesis of thermolytic DNA oligonucleotides functionalized with a single 4-hydroxy-1-butyl or 4-phosphato-/thiophosphato-1-butyl thiophosphate protecting group.

Jon S. Kauffman, S. Beaucage, S. Hess, 2007, The Journal of organic chemistry.

An Alternate Process for the Solid‐Phase Synthesis and Solid‐Phase Purification of Synthetic Nucleic Acid Sequences

S. Beaucage, A. Grajkowski, Brian M. Cawrse, 2023, Current protocols.

Quantitative in vivo receptor binding. I. Theory and application to the muscarinic cholinergic receptor

K A Frey, B W Agranoff, S. Beaucage, 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience.

An antisense oligodeoxynucleotide that depletes RI alpha subunit of cyclic AMP-dependent protein kinase induces growth inhibition in human cancer cells.

G. Tortora, S. Beaucage, H. Yokozaki, 1993, Cancer research.

Inhibition in Human Cancer Cells of Cyclic AMP-dependent Protein Kinase Induces Growth Subunit α An Antisense Oligodeoxynucleotide That Depletes

Alfredo, Tortora, Giampaolo, 2006 .

Role of DNA superhelicity in partitioning of the pSC101 plasmid

Stanley N Cohen, S. Beaucage, C. Miller, 1990, Cell.

Thermolytic properties of 3-(2-pyridyl)-1-propyl and 2-[N-methyl-N-(2-pyridyl)]aminoethyl phosphate/thiophosphate protecting groups in solid-phase synthesis of oligodeoxyribonucleotides.

S. Beaucage, J. Cieślak, 2003, Journal of Organic Chemistry.

The overlapping host responses to bacterial cyclic dinucleotides.

H. Erdjument-Bromage, C. Schindler, S. Beaucage, 2012, Microbes and infection.

An Improved Sulfurization Reagent for the Synthesis of Sulfur‐Containing Oligonucleotides

S. Beaucage, R. Iyer, W. Egan, 1990 .

Interaction of AD2+D2 protein and simian virus 40 large T antigen with the large tumor antigen binding site I.

R. Tjian, M. Caruthers, R. Meyers, 1984, Biochemistry.

An Amphipathic trans‐Acting Phosphorothioate DNA Element Delivers Uncharged PNA and PMO Nucleic Acid Sequences in Mammalian Cells

S. Beaucage, H. Jain, 2016, Current protocols in nucleic acid chemistry.

Cyclic‐di‐GMP and cyclic‐di‐AMP activate the NLRP3 inflammasome

S. Girardin, Lei Jin, C. Schindler, 2013, EMBO reports.

Algorithm-driven high-throughput screening of colloidal nanoparticles under simulated physiological and therapeutic conditions.

M. Aronova, S. Sindiri, S. Beaucage, 2017, Nanoscale.

Synthesis, Characterization, and Function of an RNA‐Based Transfection Reagent

S. Beaucage, K. Nagaraju, H. Jain, 2018, Current protocols in nucleic acid chemistry.

Convenient synthesis of a propargylated cyclic (3'-5') diguanylic acid and its "click" conjugation to a biotinylated azide.

C. Schindler, S. Beaucage, A. Gapeev, 2010, Bioconjugate chemistry.

Cyclic-diGMP and cyclic-diAMP activate the NLRP 3 Inflammasome

S. Girardin, Lei Jin, C. Schindler, 2013 .

Protection of the 2′‐Hydroxy Function of Ribonucleosides as an Iminooxymethyl Propanoate and Its 2′‐O‐Deprotection through an Intramolecular Decarboxylative Elimination Process

S. Beaucage, A. Grajkowski, J. Cieślak, 2016 .

2′‐Hydroxy Protection of Ribonucleosides as 2‐Cyano‐2,2‐Dimethylethanimine‐N‐Oxymethyl Ethers in Solid‐Phase Synthesis of RNA Sequences

S. Beaucage, A. Grajkowski, J. Cieślak, 2013, Current protocols in nucleic acid chemistry.

The 2-cyano-2,2-dimethylethanimine-N-oxymethyl group for the 2'-hydroxyl protection of ribonucleosides in the solid-phase synthesis of RNA sequences.

S. Beaucage, A. Grajkowski, J. Cieślak, 2013, Chemistry.

Deoxyoligonucleotide synthesis via the phosphoramidite method.

M. Caruthers, L. Mcbride, P. Dehaseth, 1984, Gene amplification and analysis.

Thermolytic release of covalently linked DNA oligonucleotides and their conjugates from controlled-pore glass at near neutral pH.

Jon S. Kauffman, S. Beaucage, R. Duff, 2008, Bioconjugate chemistry.

The 2-cyano-2,2-dimethylethanimine-N-oxymethyl group for the 2'-hydroxyl protection of ribonucleosides in the solid-phase synthesis of RNA sequences.

S. Beaucage, A. Grajkowski, J. Cieślak, 2013, Chemistry.