J. Hardy

发表

Discovery of an allosteric site in the caspases.

J. Wells, J. Hardy, Joni W. Lam, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Searching for new allosteric sites in enzymes.

J. Wells, J. Hardy, James A Wells, 2004, Current opinion in structural biology.

Reactive Self-Assembly of Polymers and Proteins to Reversibly Silence a Killer Protein.

J. Hardy, S. Thayumanavan, Feng Wang, 2015, Biomacromolecules.

A Nanopore Approach for Analysis of Caspase-7 Activity in Cell Lysates.

J. Hardy, M. Fahie, Min Chen, 2019, Biophysical journal.

A designed redox‐controlled caspase

J. Hardy, W. Witkowski, 2011, Protein science : a publication of the Protein Society.

Exogenous Introduction of Initiator and Executioner Caspases Results in Different Apoptotic Outcomes

J. Hardy, S. Thayumanavan, F. Anson, 2021, JACS Au.

Tracking exogenous intracellular casp‐3 using split GFP

J. Hardy, S. Thayumanavan, F. Anson, 2020, Protein science : a publication of the Protein Society.

Multiple Mechanisms of Zinc-Mediated Inhibition for the Apoptotic Caspases-3, -6, -7, and -8.

J. Hardy, S. Eron, Derek MacPherson, 2018, ACS chemical biology.

Active site–adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9

J. Hardy, D. Alfandari, Banyuhay P. Serrano, 2017, The Journal of Biological Chemistry.

Caspase-9 Activation of Procaspase-3 but Not Procaspase-6 Is Based on the Local Context of Cleavage Site Motifs and on Sequence.

J. Hardy, Ishankumar V Soni, Ishankumar V. Soni, 2021, Biochemistry.

Phosphorylation by protein kinase A disassembles the caspase-9 core

J. Hardy, Banyuhay P. Serrano, 2018, Cell Death & Differentiation.

Tri-arginine exosite patch of caspase-6 recruits substrates for hydrolysis

Caitlyn L. Mills, M. Ondrechen, J. Hardy, 2018, The Journal of Biological Chemistry.

Robust production of a peptide library using methodological synchronization

J. Hardy, K. Huber, Kevin D. Olson, 2009, 2009 IEEE 35th Annual Northeast Bioengineering Conference.

A tunable, modular approach to fluorescent protease-activated reporters.

J. Hardy, Peng Wu, S. Nicholls, 2013, Biophysical journal.

Genetic characterization of two gain-of-function alleles of the effector caspase DrICE in Drosophila

A. Bergmann, E. Flores, J. Hardy, 2015, Cell Death and Differentiation.

Modeling nonaqueous proton wires built from helical peptides: biased proton transfer driven by helical dipoles.

G. López, J. Hardy, S. Auerbach, 2012, The journal of physical chemistry. A.

Lipogels for Encapsulation of Hydrophilic Proteins and Hydrophobic Small Molecules.

R. Vachet, J. Hardy, N. Gianneschi, 2018, Biomacromolecules.

Asbestiform riebeckite (crocidolite) dissolution in the presence of Fe chelators: Implications for mineral-induced disease

A. J. Werner, J. Hardy, G. Guthrie, 1995 .

Caspase-6 latent state stability relies on helical propensity.

J. Hardy, S. Vaidya, 2011, Biochemistry.

Fighting Kinase Drug Resistance with Caspase Activators.

J. Hardy, 2018, Cell chemical biology.

Effect of Iron Binding on the Ability of Crocidolite to Cause DNA Single-Strand Breaks

J. Hardy, 1994 .

Evaluating Endosomal Escape of Caspase-3-Containing Nanomaterials Using Split GFP.

J. Hardy, S. Thayumanavan, F. Anson, 2021, Biomacromolecules.

Allosteric inhibition of the NS2B-NS3 protease from dengue virus.

W. Sherman, J. Hardy, J. Bell, 2013, ACS chemical biology.

Identifi cation of protease exosite-interacting peptides that enhance substrate cleavage kinetics

Jennifer A. Getz, J. Hardy, P. Daugherty, 2012, Biological chemistry.

Deorphanizing Caspase-3 and Caspase-9 Substrates In and Out of Apoptosis with Deep Substrate Profiling.

J. Hardy, O. Julien, Ishankumar V Soni, 2021, ACS chemical biology.

Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules.

V. Rotello, J. Hardy, A. Chompoosor, 2013, ACS nano.

Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases

M. Bollen, J. Hardy, N. Forbes, 2021, Nature Communications.

Zinc-mediated Allosteric Inhibition of Caspase-6*

J. Hardy, Elih M. Velázquez-Delgado, 2012, The Journal of Biological Chemistry.

The Unique Cofactor Region of Zika Virus NS2B-NS3 Protease Facilitates Cleavage of Key Host Proteins.

J. Hardy, T. Hobman, Anil Kumar, 2018, ACS chemical biology.

A fluorescence-activatable reporter of flavivirus NS2B–NS3 protease activity enables live imaging of infection in single cells and viral plaques

Jorge L. Arias-Arias, J. Hardy, R. Mora-Rodríguez, 2020, The Journal of Biological Chemistry.

Tumor-Associated Mutations in Caspase-6 Negatively Impact Catalytic Efficiency.

J. Hardy, Maureen E. Hill, K. Dagbay, 2017, Biochemistry.

Inhibition of caspase‐9 by stabilized peptides targeting the dimerization interface

J. Hardy, S. Ghosh, K. Huber, 2012, Biopolymers.

A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.

J. Hardy, Banyuhay P. Serrano, S. Eron, 2014, Methods in enzymology.

Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity

J. Hardy, S. Savinov, A. LeBlanc, 2018, Scientific Reports.

Caspase-6 Undergoes a Distinct Helix-Strand Interconversion upon Substrate Binding*

J. Hardy, Nicolas Bolik-Coulon, S. Savinov, 2017, The Journal of Biological Chemistry.

Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition.

J. Hardy, O. Julien, Peng Wu, 2016, ACS chemical biology.

Phosphorylation regulates assembly of the caspase-6 substrate-binding groove.

J. Hardy, Elih M. Velázquez-Delgado, 2012, Structure.

Substrate-induced conformational changes occur in all cleaved forms of caspase-6.

J. Hardy, Genevieve Abbruzzese, Elih M. Velázquez-Delgado, 2011, Journal of molecular biology.

Significance: The allosteric inhibition observed in the presence of zinc may aid in the development of allosteric caspase-6 drugs.

J. Hardy, 2012 .

Co-delivery of protein and small molecule therapeutics using nanoparticle-stabilized nanocapsules.

V. Rotello, J. Hardy, Yi‐Cheun Yeh, 2015, Bioconjugate chemistry.

Iron in Asbestos Chemistry and Carcinogenicity

J. Hardy, A. Aust, 1995 .

Mechanism of a Genetically Encoded Dark-to-Bright Reporter for Caspase Activity*

J. Hardy, K. Tremblay, Genevieve Abbruzzese, 2011, The Journal of Biological Chemistry.

Dissecting an Allosteric Switch in Caspase-7 Using Chemical and Mutational Probes*

J. Hardy, J. Wells, 2009, The Journal of Biological Chemistry.

Proline in α‐helical kink is required for folding kinetics but not for kinked structure, function, or stability of heat shock transcription factor

H. Nelson, J. Hardy, 2000, Protein science : a publication of the Protein Society.

Role of an alpha-helical bulge in the yeast heat shock transcription factor.

H. Nelson, S. Walsh, J. Hardy, 2000, Journal of molecular biology.

Dual Site Phosphorylation of Caspase-7 by PAK2 Blocks Apoptotic Activity by Two Distinct Mechanisms.

J. Hardy, S. Eron, Kishore Raghupathi, 2017, Structure.

Structural basis of fluorescence quenching in caspase activatable‐GFP

J. Hardy, S. Nicholls, 2013, Protein science : a publication of the Protein Society.

Caspase-9 CARD : core domain interactions require a properly formed active site.

J. Hardy, Banyuhay P. Serrano, K. Huber, 2018, The Biochemical journal.

Colorimetric Cotton Swab for Viral Protease Detection.

Trisha L. Andrew, J. Hardy, S. Thayumanavan, 2022, Analytical chemistry.

Mechanism of zinc‐mediated inhibition of caspase‐9

J. Hardy, K. Huber, Kristen L. Huber, 2012, Protein science : a publication of the Protein Society.

Chapter 17:A Link Means a Lot: Disulfide Tethering in Structure-Based Drug Design

J. Hardy, 2007 .

A Link Means a Lot : Disulfide Tethering in Structure-Based Drug Design

J. Hardy, 2007 .

Cysteine Disulfide Traps Reveal Distinct Conformational Ensembles in Dengue Virus NS2B-NS3 Protease.

J. Hardy, M. Yildiz, Maureen E. Hill, 2018, Biochemistry.

The wing in yeast heat shock transcription factor (HSF) DNA-binding domain is required for full activity.

H. Nelson, J. Hardy, O. Littlefield, 2001, Nucleic acids research.

Utilizing Inverse Emulsion Polymerization To Generate Responsive Nanogels for Cytosolic Protein Delivery.

J. Hardy, S. Thayumanavan, F. Anson, 2017, Molecular pharmaceutics.

The effect of iron binding on the ability of crocidolite asbestos to catalyze DNA single-strand breaks.

J. Hardy, A E Aust, J A Hardy, 1995, Carcinogenesis.

Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions

J. Hardy, K. Dagbay, 2017, Proceedings of the National Academy of Sciences.

Phosphorylation by protein kinase A disassembles the caspase-9 core

J. Hardy, Banyuhay P. Serrano, 2018, Cell Death & Differentiation.

Using rigidity analysis to probe mutation-induced structural changes in proteins

Ileana Streinu, Filip Jagodzinski, Jeanne Hardy, 2011, 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW).

L2′ loop is critical for caspase‐7 active site formation

J. Hardy, W. Witkowski, 2009, Protein science : a publication of the Protein Society.

Multiple Mechanisms of Zinc-Mediated Inhibition for the Apoptotic Caspases-3, -6, -7, and -8.

J. Hardy, S. Eron, Derek MacPherson, 2018, ACS chemical biology.

Cysteine Disul fi de Traps Reveal Distinct Conformational Ensembles in Dengue Virus NS 2 BNS 3 Protease

J. Hardy, M. Yildiz, Maureen E. Hill, 2019 .

Inhibition of caspase‐9 by stabilized peptides targeting the dimerization interface

J. Hardy, S. Ghosh, Kristen L. Huber, 2012, Biopolymers.

Chemoproteomics Using Nucleotide Acyl Phosphates Reveals an ATP Binding Site at the Dimer Interface of Procaspase-6.

J. Hardy, S. Savinov, J. Kozarich, 2019, Biochemistry.

Caspase-9 CARD : core domain interactions require a properly formed active site.

J. Hardy, Banyuhay P. Serrano, Kristen L. Huber, 2018, The Biochemical journal.

Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity

J. Hardy, S. Savinov, A. LeBlanc, 2018, Scientific Reports.