T. Härd

T. Härd, M. Sandgren, G. Westermark, 2021, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Folding-Reaction Coupling in a Self-Cleaving Protein.

Johan Åqvist, J. Åqvist, T. Härd, 2012, Journal of chemical theory and computation.

Self-Cleaving Mucins

T. Härd, 2013 .

Production of Ready-To-Use Functionalized Sup35 Nanofibrils Secreted by Komagataella pastoris.

T. Härd, M. Sandgren, J. Blomqvist, 2018, ACS nano.

Free Energy Calculations Predict Sequence Specificity In DNA-drug Complexes

L. Nilsson, T. Härd, 1991 .

Crystallization and preliminary studies of the DNA-binding runt domain of AML1.

T. Grundström, M. Wolf-Watz, T. Härd, 2001, Acta crystallographica. Section D, Biological crystallography.

Preliminary NMR studies of Thermus thermophilus ribosomal protein S19 overproduced in Escherichia coli

A. Liljas, H. Berglund, T. Härd, 1997, FEBS letters.

On the pH dependence of amide proton exchange rates in proteins.

L. Nilsson, M. Eriksson, T. Härd, 1995, Biophysical journal.

Coupled chemistry kinetics demonstrate the utility of functionalized Sup35 amyloid nanofibrils in biocatalytic cascades

T. Härd, M. Sandgren, Benjamin Schmuck, 2019, The Journal of Biological Chemistry.

Reduced DNA flexibility in complexes with a type II DNA binding protein.

T. Härd, D. Kearns, 1990, Biochemistry.

Induced CD of DNA intercalators: Electric dipole allowed transitions

B. Nordén, T. Härd, R. Lyng, 1987, Biopolymers.

Structure and Dynamics of DNA and DNA-Adduct Complexes Studied with Polarized Light Spectroscopy

B. Nordén, T. Härd, 1987 .

Intermolecular interactions between the SH3 domain and the proline‐rich TH region of Bruton's tyrosine kinase

M. Vihinen, T. Härd, H. Hansson, 2001, FEBS letters.

Anisotropic motions in intercalative DNA-dye complexes

T. Härd, D. Kearns, 1986 .

Anisotropic overall and internal motions of short DNA fragments.

T. Härd, D. Kearns, 1986, Nucleic acids research.

Inhibition of amyloid formation.

T. Härd, Christofer Lendel, 2012, Journal of molecular biology.

Synthesis and NMR spectrum of [13C18]‐meso‐hexestrol, a fully carbon‐13 substituted ligand for NMR studies of the estrogen receptor

J. Katzenellenbogen, T. Härd, M. Kochanny, 1993 .

Enantioselective interactions of inversion‐labile trigonal iron(II) complexes upon binding to DNA

B. Nordén, T. Härd, 1986, Biopolymers.

Sequence-specific DNA binding by the glucocorticoid receptor DNA-binding domain is linked to a salt-dependent histidine protonation.

T. Härd, T. Lundbäck, S. van den Berg, 2000, Biochemistry.

Solution structure of the glucocorticoid receptor DNA-binding domain.

K. Yamamoto, J. Gustafsson, K. Yamamoto, 1990, Science.

On the use of chiral compounds for probing the DNA handedness: Z to B conversion in poly(dGm5dC) upon binding of Fe(phen)3(2+) and Ru(phen)3(2+).

B. Nordén, C. Hiort, T. Härd, 1987, Journal of biomolecular structure & dynamics.

NMR studies of protein–nucleic acid complexes: structures, solvation, dynamics and coupled protein folding

T. Härd, 1999, Quarterly Reviews of Biophysics.

1H NMR studies of the glucocorticoid receptor DNA-binding domain: sequential assignments and identification of secondary structure elements.

J. Gustafsson, R. Kaptein, R. Boelens, 1990, Biochemistry.

Rapid screening for improved solubility of small human proteins produced as fusion proteins in Escherichia coli

Martin Hammarström, Helena Berglund, Martin Hammarström, 2002, Protein science : a publication of the Protein Society.

Solution structure and DNA-binding properties of a thermostable protein from the archaeon Sulfolobus solfataricus

S. Knapp, R. Ladenstein, T. Härd, 1994, Nature Structural Biology.

Refined solution structure of the glucocorticoid receptor DNA-binding domain.

J. Gustafsson, H. Berglund, T. Härd, 1994, Biochemistry.

The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding.

U. Sauer, T. Grundström, M. Wolf-Watz, 2002, Journal of molecular biology.

Affibody-Mediated Sequestration of Amyloid β Demonstrates Preventive Efficacy in a Transgenic Alzheimer’s Disease Mouse Model

Fredrik Y Frejd, T. Wisniewski, T. Härd, 2019, Front. Aging Neurosci..

Identification of proteins that specifically recognize and bind protofibrillar aggregates of amyloid-β

T. Härd, E. Wahlberg, M. Sandgren, 2017, Scientific Reports.

Thermodynamics of sequence-specific protein-DNA interactions.

T. Härd, T. Lundbäck, 1996, Biophysical chemistry.

His tag effect on solubility of human proteins produced in Escherichia coli: a comparison between four expression vectors

Martin Hammarström, Helena Berglund, Martin Hammarström, 2004, Journal of Structural and Functional Genomics.

A hexameric peptide barrel as building block of amyloid-β protofibrils.

O. Antzutkin, N. Nielsen, T. Härd, 2014, Angewandte Chemie.

Stabilization of neurotoxic Alzheimer amyloid-β oligomers by protein engineering

C. Dobson, L. Lannfelt, T. Härd, 2010, Proceedings of the National Academy of Sciences.

Stabilization of a β-hairpin in monomeric Alzheimer's amyloid-β peptide inhibits amyloid formation

T. Härd, S. Ståhl, A. Jonsson, 2008, Proceedings of the National Academy of Sciences.

The solution structure of ribosomal protein L18 from Thermus thermophilus reveals a conserved RNA-binding fold.

H. Berglund, T. Härd, M. Garber, 2002, The Biochemical journal.

Effect of N-terminal solubility enhancing fusion proteins on yield of purified target protein

Martin Hammarström, H. Berglund, T. Härd, 2006, Journal of Structural and Functional Genomics.

The N-terminal Regions of Estrogen Receptor α and β Are Unstructured in Vitro and Show Different TBP Binding Properties*

T. Härd, A. Wright, J A Gustafsson, 2001, The Journal of Biological Chemistry.

Cooperativity and specificity in the interactions between DNA and the glucocorticoid receptor DNA-binding domain.

J. Gustafsson, R. Rigler, T. Härd, 1990, Biochemistry.

Structural transitions of chromatin at low salt concentrations: a flow linear dichroism study.

B. Nordén, P. Nielsen, T. Härd, 1985, Biochemistry.

Backbone dynamics of the glucocorticoid receptor DNA-binding domain.

K. Dahlman-Wright, J. Gustafsson, H. Berglund, 1992, Biochemistry.

The solution structure of ribosomal protein L36 from Thermus thermophilus reveals a zinc-ribbon-like fold.

T. Härd, M. Garber, L. Kloo, 2000, Journal of molecular biology.

A type II DNA-binding protein genetically engineered for fluorescence spectroscopy: the "arm" of transcription factor 1 binds in the DNA grooves.

E. Geiduschek, T. Härd, D. Kearns, 1989, Biochemistry.

Fluorescence studies of a single tyrosine in a type II DNA binding protein.

E. Geiduschek, K. Appelt, T. Härd, 1989, Biochemistry.

Binding of human proteins to amyloid-β protofibrils.

H. Zetterberg, T. Härd, Christofer Lendel, 2015, ACS chemical biology.

SEA domain autoproteolysis accelerated by conformational strain: mechanistic aspects.

Denny G. A. Johansson, T. Härd, A. Sandberg, 2008, Journal of molecular biology.

Simulations of NMR pulse sequences during equilibrium and non-equilibrium chemical exchange

T. Härd, M. Helgstrand, P. Allard, 2000, Journal of biomolecular NMR.

Conformational dynamics and molecular recognition: backbone dynamics of the estrogen receptor DNA-binding domain.

H. Berglund, T. Härd, S. van den Berg, 1999, Journal of molecular biology.

Structural characterization of a short peptide fragment that mediates estrogen-receptor dimerization.

T. Härd, H. Baumann, 1995, European journal of biochemistry.

Molecular Dynamics Simulation of a DNA Binding Protein free and in Complex with DNA

L. Nilsson, M. Eriksson, T. Härd, 1994 .

A comparison of 15N NMR relaxation measurements with a molecular dynamics simulation: Backbone dynamics of the glucocorticoid receptor DNA‐binding domain

L. Nilsson, H. Berglund, M. Eriksson, 1993, Proteins.

A non-conservative polymorphism in the IL-6 signal transducer (IL6ST)/gp130 is associated with myocardial infarction in a hypertensive population

J. Borén, T. Hedner, C. Ohlsson, 2008, Regulatory Peptides.

Protein engineering to stabilize soluble amyloid β‐protein aggregates for structural and functional studies

T. Härd, 2011, The FEBS journal.

A synthetic approach to analysis of the structural zinc site of alcohol dehydrogenase.

H. Jörnvall, T. Bergman, T. Härd, 1993, Advances in experimental medicine and biology.

New insights into multiple coagulation factor deficiency from the solution structure of human MCFD2.

Y. Lindqvist, T. Härd, J. Guy, 2008, Journal of molecular biology.

DNA-binding surface of the Sso7d protein from Sulfolobus solfataricus.

S. Knapp, A. Karshikoff, R. Ladenstein, 1995, Journal of molecular biology.

The kinetics of TEM1 antibiotic degrading enzymes that are displayed on Ure2 protein nanofibrils in a flow reactor

T. Härd, M. Sandgren, Benjamin Schmuck, 2018, PloS one.

A fine-tuned composition of protein nanofibrils yields an upgraded functionality of displayed antibody binding domains.

T. Härd, M. Sandgren, Benjamin Schmuck, 2017, Biotechnology journal.

Amyloid Fibrils: Formation, Polymorphism, and Inhibition.

T. Härd, Torleif Härd, 2014, The journal of physical chemistry letters.

Contact between the β1 and β2 Segments of α-Synuclein that Inhibits Amyloid Formation.

T. Härd, D. Willbold, W. Hoyer, 2015, Angewandte Chemie.

Solution structure of the ribosomal RNA binding protein S15 from Thermus thermophilus

Helena Berglund, A. Serganov, H. Berglund, 1997, Nature Structural Biology.

Thermodynamic characterization of non-sequence-specific DNA-binding by the Sso7d protein from Sulfolobus solfataricus.

S. Knapp, R. Ladenstein, T. Härd, 1998, Journal of molecular biology.

Ansig for Windows: An interactive computer program for semiautomatic assignment of protein NMR spectra

P. Kraulis, T. Härd, M. Helgstrand, 2000, Journal of biomolecular NMR.

Another piece of the ribosome: solution structure of S16 and its location in the 30S subunit.

V. Ramakrishnan, W. M. Clemons, B. Wimberly, 2000, Structure.

Recombinant amyloid beta-peptide production by coexpression with an affibody ligand

C. Dobson, T. Härd, W. Hoyer, 2008, BMC biotechnology.

Photo-CIDNP study of the interaction between the glucocorticoid receptor DNA-binding domain and glucocorticoid response elements

K. Yamamoto, J. Gustafsson, R. Kaptein, 1991, Journal of biomolecular NMR.

A truncated and dimeric format of an Affibody library on bacteria enables FACS‐mediated isolation of amyloid‐beta aggregation inhibitors with subnanomolar affinity

T. Härd, S. Ståhl, J. Löfblom, 2015, Biotechnology journal.

Thermodynamics of sequence-specific glucocorticoid receptor-DNA interactions.

J. Gustafsson, T. Härd, J. Carlstedt-Duke, 1994, Biochemistry.

Thermodynamics of the glucocorticoid receptor-DNA interaction: binding of wild-type GR DBD to different response elements.

J. Gustafsson, T. Härd, J. Carlstedt-Duke, 1993, Biochemistry.

Solution structure of a mammalian PCB-binding protein in complex with a PCB

H. Barnes, J. Gustafsson, T. Härd, 1995, Nature Structural Biology.

Amyloid-β Protofibrils: Size, Morphology and Synaptotoxicity of an Engineered Mimic

T. Härd, I. Benilova, A. Dubnovitsky, 2013, PloS one.

Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering

C. Dobson, L. Lannfelt, T. Härd, 2011, Alzheimer's & Dementia.

Comparing the folding free‐energy landscapes of Aβ42 variants with different aggregation properties

A. Irbäck, Simon Mitternacht, T. Härd, 2010, Proteins.

Interaction of Alzheimer's A beta peptide with an engineered binding protein--thermodynamics and kinetics of coupled folding-binding.

T. Härd, W. Hoyer, 2008, Journal of molecular biology.

Chloride binding by the AML1/Runx1 transcription factor studied by NMR

T. Grundström, M. Wolf-Watz, T. Härd, 2001, FEBS letters.

Association of short DNA fragments: Steady state fluorescence polarization study

T. Härd, D. Kearns, 1986, Biopolymers.

Molecular flexibility of extended and compacted polynucleosomes

B. Nordén, P. Nielsen, T. Härd, 1988, European Biophysics Journal.

Out-of-plane mobility in the ethidium/DNA complex.

T. Härd, 1987, Biopolymers.

Structural characterization of a minimal functional transactivation domain from the human glucocorticoid receptor.

K. Dahlman-Wright, J. Gustafsson, T. Härd, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Solution structure of the ribosomal protein S19 from Thermus thermophilus.

T. Härd, M. Garber, A. Rak, 1999, Journal of molecular biology.

A complete Hermitian operator basis set for any spin quantum number.

T. Härd, P. Allard, 2001, Journal of magnetic resonance.

Sequestration of the Aβ Peptide Prevents Toxicity and Promotes Degradation In Vivo

C. Dobson, D. Lomas, T. Härd, 2010, PLoS biology.

Protofibrillar and Fibrillar Amyloid-β Binding Proteins in Cerebrospinal Fluid.

H. Zetterberg, T. Härd, M. Sandgren, 2018, Journal of Alzheimer's disease : JAD.

Biophysical characterization of ZSPA‐1—A phage‐display selected binder to protein A

Jakob Dogan, T. Härd, E. Wahlberg, 2004, Protein science : a publication of the Protein Society.

An affibody in complex with a target protein: Structure and coupled folding

H. Berglund, T. Härd, E. Wahlberg, 2003, Proceedings of the National Academy of Sciences of the United States of America.

High-affinity binding to staphylococcal protein A by an engineered dimeric Affibody molecule.

L. Abrahmsén, T. Härd, A. Dubnovitsky, 2013, Protein engineering, design & selection : PEDS.

Thermodynamics of folding, stabilization, and binding in an engineered protein--protein complex.

Jakob Dogan, T. Härd, E. Wahlberg, 2004, Journal of the American Chemical Society.

Structural basis for molecular recognition in an affibody:affibody complex.

Jakob Dogan, T. Härd, Christofer Lendel, 2006, Journal of molecular biology.

Thermodynamics of folding and binding in an affibody:affibody complex.

Jakob Dogan, T. Härd, Christofer Lendel, 2006, Journal of molecular biology.

Recombinant amyloid beta-peptide production by coexpression with an affibody ligand

C. Dobson, T. Härd, W. Hoyer, 2008 .

A β‐Hairpin‐Binding Protein for Three Different Disease‐Related Amyloidogenic Proteins

Ewa A. Mirecka, T. Härd, D. Willbold, 2015, Chembiochem : a European journal of chemical biology.

Structure and Function of the DNA-Binding Domain of the Glucocorticoid Receptor and Other Members of the Nuclear Receptor Supergene Family

J. Gustafsson, T. Härd, J. Gustafsson, 1993 .

Recombinant amyloid beta-peptide production by coexpression with an affibody ligand.

C. Dobson, T. Härd, W. Hoyer, 2008 .

Structure and backbone dynamics of Apo-CBFbeta in solution.

T. Grundström, M. Wolf-Watz, T. Härd, 2001, Biochemistry.

A method for production of 13C/15N double labelled RNA in E. coli, and subsequent in vitro synthesis of ribonucleotide 5' triphosphates.

T. Härd, T. Nyholm, M. Andäng, 1995, Journal of biochemical and biophysical methods.

Protein autoproteolysis: conformational strain linked to the rate of peptide cleavage by the pH dependence of the N --> O acyl shift reaction.

Denny G. A. Johansson, J. Åqvist, T. Härd, 2009, Journal of the American Chemical Society.

SEA domain autoproteolysis accelerated by conformational strain: energetic aspects.

Denny G. A. Johansson, T. Härd, A. Sandberg, 2008, Journal of molecular biology.

Conformational stabilization of an engineered binding protein.

T. Härd, E. Wahlberg, 2006, Journal of the American Chemical Society.

Screening methods to determine biophysical properties of proteins in structural genomics.

Martin Hammarström, H. Berglund, T. Härd, 2003, Analytical biochemistry.

Contact between the β1 and β2 Segments of α-Synuclein that Inhibits Amyloid Formation.

T. Härd, D. Willbold, W. Hoyer, 2015, Angewandte Chemie.

Faculty Opinions recommendation of Functional amyloids as natural storage of peptide hormones in pituitary secretory granules.

T. Härd, W. Hoyer, 2009 .

Structural basis for Myf and Psa fimbriae‐mediated tropism of pathogenic strains of Yersinia for host tissues

T. Härd, S. Paavilainen, S. Teneberg, 2016, Molecular microbiology.