V. Cryns

Deyang Yu, Jacqueline A. Brinkman, D. Sherman, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

αB-crystallin and HspB2 deficiency is protective from diet-induced glucose intolerance

V. Cryns, M. Schipma, B. Layden, 2016, Genomics data.

Preclinical Breast Cancer Models to Investigate Metabolic Priming by Methionine Restriction.

V. Cryns, Dmitry Malin, E. Strekalova, 2019, Methods in molecular biology.

The retinoblastoma gene in human pituitary tumors.

V. Cryns, A. Arnold, A. Klibanski, 1993, The Journal of clinical endocrinology and metabolism.

The small heat shock protein alpha B-crystallin negatively regulates apoptosis during myogenic differentiation by inhibiting caspase-3 activation.

F. Chen, V. Cryns, Susan Sam, 2002, The Journal of biological chemistry.

Genomic localization of novel candidate tumor suppressor gene loci in human parathyroid adenomas.

V. Cryns, A. Arnold, V. Cryns, 1996, Cancer research.

Loss of the retinoblastoma tumor-suppressor gene in parathyroid carcinoma.

A. Thor, W. Benedict, V. Cryns, 1994, The New England journal of medicine.

The small heat shock protein HspB2 is a novel anti-apoptotic protein that inhibits apical caspase activation in the extrinsic apoptotic pathway

F. Chen, F. Yehiely, V. Cryns, 2010, Breast Cancer Research and Treatment.

METFORMIN USE IS ASSOCIATED WITH IMPROVED SURVIVAL IN VETERANS WITH ADVANCED PROSTATE CANCER ON ANDROGEN DEPRIVATION THERAPY: MP53‐08

V. Cryns, T. Downs, K. Richards, 2017 .

Crucial Role of the Specificity-determining Loop of the Integrin β4 Subunit in the Binding of Cells to Laminin-5 and Outside-in Signal Transduction*

V. Cryns, M. Werner, S. Hopkinson, 2003, Journal of Biological Chemistry.

Peroxisome Proliferator-activated Receptor γ Agonists Promote TRAIL-induced Apoptosis by Reducing Survivin Levels via Cyclin D3 Repression and Cell Cycle Arrest*

V. Cryns, E. J. Lee, J. Jameson, 2005, Journal of Biological Chemistry.

Plakoglobin Deficiency Protects Keratinocytes from

V. Cryns, L. Godsel, K. Green, 2007 .

Caspase inhibition reduces myocyte cell death induced by myocardial ischemia and reperfusion in vivo.

F. Klocke, V. Cryns, Y. Byun, 1999, Journal of molecular and cellular cardiology.

The mitochondrial apoptotic pathway is activated by serum and glucose deprivation in cardiac myocytes.

R. Kitsis, V. Cryns, S. Bialik, 1999, Circulation research.

S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells

J. Coon, V. Cryns, P. Lewis, 2019, Breast Cancer Research and Treatment.

Breast cancer risk for women with diabetes and the impact of metformin: A meta‐analysis

A. Trentham-Dietz, O. Alagoz, V. Cryns, 2022, Cancer medicine.

Induction of cancer cell death by self-assembling nanostructures incorporating a cytotoxic peptide.

S. Stupp, V. Cryns, V. Band, 2010, Cancer research.

A Novel Nanoparticulate Formulation of Arsenic Trioxide with Enhanced Therapeutic Efficacy in a Murine Model of Breast Cancer

T. O’Halloran, V. Cryns, M. Raja, 2010, Clinical Cancer Research.

Minireview: Basal-Like Breast Cancer: From Molecular Profiles to Targeted Therapies

V. Cryns, D. Toft, 2010 .

AlphaB-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer.

C. Perou, T. Nielsen, J. Moyano, 2005, The Journal of clinical investigation.

Aspirin Sensitizes Cancer Cells to TRAIL–Induced Apoptosis by Reducing Survivin Levels

J. Bosman, V. Cryns, V. Jordan, 2008, Clinical Cancer Research.

Photoexpulsion of surface-grafted ruthenium complexes and subsequent release of cytotoxic cargos to cancer cells from mesoporous silica nanoparticles.

J. F. Stoddart, V. Cryns, Xinqing Chen, 2013, Journal of the American Chemical Society.

alphaB-crystallin is a novel predictor of resistance to neoadjuvant chemotherapy in breast cancer.

A. Rademaker, W. Gradishar, M. Morrow, 2008, Breast cancer research and treatment.

αB-crystallin is a novel predictor of resistance to neoadjuvant chemotherapy in breast cancer

A. Rademaker, W. Gradishar, M. Morrow, 2008, Breast Cancer Research and Treatment.

The Small Heat Shock Protein αB-Crystallin Negatively Regulates Cytochrome c- and Caspase-8-dependent Activation of Caspase-3 by Inhibiting Its Autoproteolytic Maturation*

F. Chen, V. Cryns, M. Kamradt, 2001, The Journal of Biological Chemistry.

Triple Negative Breast Carcinoma and the Basal Phenotype: From Expression Profiling to Clinical Practice

N. Sneige, W. Symmans, V. Cryns, 2007, Advances in anatomic pathology.

Deconstructing the molecular portrait of basal-like breast cancer.

T. Nielsen, J. Moyano, Joseph R Evans, 2006, Trends in molecular medicine.

Coassembled cytotoxic and pegylated peptide amphiphiles form filamentous nanostructures with potent antitumor activity in models of breast cancer.

S. Stupp, V. Cryns, Tyson J. Moyer, 2012, ACS nano.

Methyl-Metabolite Depletion Elicits Adaptive Responses to Support Heterochromatin Stability and Epigenetic Persistence

Deyang Yu, Shany E. Yang, Dudley Lamming, 2019, bioRxiv.

Minireview: Basal-like breast cancer: from molecular profiles to targeted therapies.

V. Cryns, D. Toft, 2011, Molecular endocrinology.

αB-crystallin expression in breast cancer is associated with brain metastasis

Charles M Perou, C. Fan, C. Perou, 2015, npj Breast Cancer.

Caspase Cleavage of HER-2 Releases a Bad-like Cell Death Effector*

F. Chen, F. Yehiely, V. Cryns, 2008, Journal of Biological Chemistry.

Proteolysis of the Mismatch Repair Protein MLH1 by Caspase-3 Promotes DNA Damage-induced Apoptosis*

F. Chen, V. Cryns, O. K. Arseven, 2004, Journal of Biological Chemistry.

Frequent loss of chromosome arm Ip DNA in parathyroid adenomas

V. Cryns, A. Arnold, H. Tahara, 1995, Genes, chromosomes & cancer.

αB-crystallin: Portrait of a malignant chaperone as a cancer therapeutic target.

V. Cryns, V. Petrovic, Dmitry Malin, 2016, Pharmacology & therapeutics.

αB-Crystallin: A Novel Regulator of Breast Cancer Metastasis to the Brain

C. Miller, L. Carey, C. Livasy, 2013, Clinical Cancer Research.

αB-Crystallin promotes oncogenic transformation and inhibits caspase activation in cells primed for apoptosis by Rb inactivation

V. Cryns, V. Petrovic, Dmitry Malin, 2013, Breast Cancer Research and Treatment.

Combination therapy with androgen deprivation for hormone sensitive prostate cancer: A new frontier

V. Cryns, D. Jarrard, Shivashankar Damodaran, 2018, Asian journal of urology.

Regulation of αB-crystallin gene expression by the transcription factor Ets1 in breast cancer

Joseph R Evans, J. Bosman, F. Yehiely, 2009, Breast Cancer Research and Treatment.

Aberrant expression of glycogen synthase kinase-3β in human breast and head and neck cancer

T. Taxter, T. O’Halloran, V. Cryns, 2018, Oncology letters.

NanoFlares for the detection, isolation, and culture of live tumor cells from human blood

Chad A Mirkin, Wei Wang, Chonghui Cheng, 2014, Proceedings of the National Academy of Sciences.

Metformin sensitizes triple-negative breast cancer to proapoptotic TRAIL receptor agonists by suppressing XIAP expression

V. Cryns, Dmitry Malin, E. Strekalova, 2017, Breast Cancer Research and Treatment.

Synthetic Lethal Metabolic Targeting of Androgen-Deprived Prostate Cancer Cells with Metformin

V. Cryns, D. Jarrard, Tariq A. Khemees*, 2020, Molecular Cancer Therapeutics.

A tetracycline-regulated adenovirus encoding dominant-negative caspase-9 is regulated in rat brain and protects against neurotoxin-induced cell death in vitro, but not in vivo

V. Cryns, A. Ebert, Xiaolong He, 2005, Experimental Neurology.

The Differentiation-dependent Desmosomal Cadherin Desmoglein 1 Is a Novel Caspase-3 Target That Regulates Apoptosis in Keratinocytes*

F. Chen, V. Cryns, K. Green, 2006, Journal of Biological Chemistry.

Biological evaluation of pH-responsive polymer-caged nanobins for breast cancer therapy.

S. Nguyen, T. O’Halloran, V. Cryns, 2010, ACS nano.

Early N-Terminal Changes and Caspase-6 Cleavage of Tau in Alzheimer's Disease

D. Bennett, R. Berry, S. Weintraub, 2004, The Journal of Neuroscience.

Caspase cleavage of tau: Linking amyloid and neurofibrillary tangles in Alzheimer's disease

R. Berry, V. Cryns, S. Lagalwar, 2003, Proceedings of the National Academy of Sciences of the United States of America.

GSK-3 inhibition overcomes chemoresistance in human breast cancer.

K. White, T. O’Halloran, V. Cryns, 2016, Cancer letters.

AlphaB-crystallin: a novel marker of invasive basal-like and metaplastic breast carcinomas.

J. Moyano, V. Cryns, E. Wiley, 2008, Annals of diagnostic pathology.

Ionizing Radiation-induced Proteomic Oxidation in Escherichia coli

Deyang Yu, M. Sussman, M. Cox, 2020, Molecular & Cellular Proteomics.

Self-assembled peptide nanostructures targeting death receptor 5 and encapsulating paclitaxel as a multifunctional cancer therapy.

S. Stupp, V. Cryns, Tyson J. Moyer, 2019, ACS biomaterials science & engineering.

Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo

R. Berry, V. Cryns, L. Binder, 2006, Journal of neurochemistry.

C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease.

J. Kuret, R. Berry, V. Cryns, 2000, Journal of cell science.

Caspase Proteolysis of Desmin Produces a Dominant-negative Inhibitor of Intermediate Filaments and Promotes Apoptosis*

F. Chen, V. Cryns, Y. Capetanaki, 2003, The Journal of Biological Chemistry.

ERK-regulated αB-Crystallin Induction by Matrix Detachment Inhibits Anoikis and Promotes Lung Metastasis in vivo

W. Gradishar, V. Cryns, V. Petrovic, 2015, Oncogene.

Abstract A69: aB-crystallin: A novel regulator of breast cancer metastasis to the brain

V. Cryns, V. Petrovic, A. Ugolkov, 2013 .

Lysine oxidase exposes a dependency on the thioredoxin antioxidant pathway in triple-negative breast cancer cells

A. Zamyatnin, V. Cryns, Dmitry Malin, 2020, Breast Cancer Research and Treatment.

Neurobiology of Disease Early N-Terminal Changes and Caspase-6 Cleavage of Tau in Alzheimer ’ s Disease

D. Bennett, R. Berry, S. Weintraub, 2004 .

Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery.

V. Cryns, R. Talanian, K. Brady, 2000, Journal of medicinal chemistry.

Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery.

J. F. Stoddart, V. Cryns, Xinqing Chen, 2015, Nanoscale.

Metformin Use is Associated with Improved Survival for Patients with Advanced Prostate Cancer on Androgen Deprivation Therapy

V. Cryns, T. Downs, K. Richards, 2018, The Journal of urology.

Assessing In Situ Phosphoinositide-Protein Interactions Through Fluorescence Proximity Ligation Assay in Cultured Cells.

V. Cryns, Mo Chen, Tianmu Wen, 2021, Methods in molecular biology.

Caspase Proteolysis of the Cohesin Component RAD21 Promotes Apoptosis*

F. Chen, M. McKay, V. Cryns, 2002, The Journal of Biological Chemistry.

Peroxisome proliferator-activated receptor gamma agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest.

F. Chen, V. Cryns, J. Jameson, 2005, The Journal of biological chemistry.

Lipid transfer proteins initiate nuclear phosphoinositide signaling

V. Cryns, Mo Chen, R. Anderson, 2023, bioRxiv.

Proteases to die for.

V. Cryns, V Cryns, J Yuan, 1998, Genes & development.

Plakoglobin deficiency protects keratinocytes from apoptosis.

F. Chen, V. Cryns, L. Godsel, 2007, The Journal of investigative dermatology.

Regulation of Phosphoinositide Signaling by Scaffolds at Cytoplasmic Membranes

V. Cryns, Narendra Thapa, Tianmu Wen, 2023, Biomolecules.

Targeting the methionine addiction of cancer.

V. Cryns, J. C. Sedillo, 2022, American journal of cancer research.

A p53–phosphoinositide signalosome regulates nuclear AKT activation

Suyong Choi, V. Cryns, Mo Chen, 2022, Nature Cell Biology.

Methionine Deprivation Induces a Targetable Vulnerability in Triple-Negative Breast Cancer Cells by Enhancing TRAIL Receptor-2 Expression

V. Cryns, Dmitry Malin, E. Strekalova, 2015, Clinical Cancer Research.

Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery.

V. Cryns, Xinqing Chen, Daniel P. Ferris, 2015, Nanoscale.

Aspirin Sensitizes Cancer Cells to TRAIL–Induced Apoptosis by Reducing Survivin Levels

J. Bosman, V. Cryns, V. Jordan, 2008, Clinical Cancer Research.

Enhanced Metastasis Suppression by Targeting TRAIL Receptor 2 in a Murine Model of Triple-Negative Breast Cancer

V. Cryns, J. Koblinski, Fen Chen, 2011, Clinical Cancer Research.

Antitumor activity of peptide amphiphile nanofiber-encapsulated camptothecin.

S. Stupp, V. Cryns, Tyson J. Moyer, 2011, ACS nano.

GSK-3 inhibition overcomes chemoresistance in human breast cancer.

K. White, T. O’Halloran, V. Cryns, 2016, Cancer letters.