H. Koeffler

发表

Modulation of DNA binding properties of CCAAT/enhancer binding protein epsilon by heterodimer formation and interactions with NFkappaB pathway.

A. Chumakov, A. Silla, E. Williamson, 2005, Blood.

p53 transactivation through various p53‐responsive elements

Carl W. Miller, A. Chumakov, H. Koeffler, 1996, Molecular carcinogenesis.

Mutations of p53 and human papillomavirus infection in cervical carcinoma

Carl W. Miller, H. Koeffler, C. Miller, 1993, Cancer.

Posttranscriptional stabilization underlies p53-independent induction of p21WAF1/CIP1/SDI1 in differentiating human leukemic cells.

M. Fey, A. Tobler, H. Koeffler, 1995, The Journal of clinical investigation.

Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia

S. Ogawa, T. Haferlach, Motohiro Kato, 2010, Haematologica.

Zanthoxyli Fructus induces growth arrest and apoptosis of LNCaP human prostate cancer cells in vitro and in vivo in association with blockade of the AKT and AR signal pathways.

Y. Ohtsuki, H. Koeffler, Yang Yang, 2006, Oncology reports.

Methylation, expression, and mutation analysis of the cell cycle control genes in human brain tumors

Carl W. Miller, D. Xie, K. Black, 2002, Oncogene.

Cyclin E is the only cyclin-dependent kinase 2-associated cyclin that predicts metastasis and survival in early stage non-small cell lung cancer.

H. Koeffler, S. Diederichs, W. Berdel, 2001, Cancer research.

Cell cycle arrest induced by the vitamin D(3) analog EB1089 in NCI-H929 myeloma cells is associated with induction of the cyclin-dependent kinase inhibitor p27.

H. Koeffler, Y. Y. Lee, W. Park, 2000, Experimental cell research.

Inhibition of mTORC1 by RAD001 (everolimus) potentiates the effects of 1,25-dihydroxyvitamin D(3) to induce growth arrest and differentiation of AML cells in vitro and in vivo.

H. Koeffler, T. Ikezoe, Jing Yang, 2010, Experimental hematology.

Blockade of mTOR signaling potentiates the ability of histone deacetylase inhibitor to induce growth arrest and differentiation of acute myelogenous leukemia cells

H. Koeffler, T. Ikezoe, Jing Yang, 2008, Leukemia.

Blockade of MEK/ERK signaling enhances sunitinib-induced growth inhibition and apoptosis of leukemia cells possessing activating mutations of the FLT3 gene.

H. Koeffler, N. Komatsu, T. Ikezoe, 2008, Leukemia research.

RTP801 is a novel retinoic acid-responsive gene associated with myeloid differentiation.

H Phillip Koeffler, W. Hofmann, R. Virk, 2007, Experimental hematology.

ZD6474 induces growth arrest and apoptosis of GIST‐T1 cells, which is enhanced by concomitant use of sunitinib

H. Koeffler, Wei-Guo Zhu, Yang Yang, 2006, Cancer science.

Effect of SU11248 on gastrointestinal stromal tumor‐T1 cells: Enhancement of growth inhibition via inhibition of 3‐kinase/Akt/mammalian target of rapamycin signaling

H. Koeffler, Yang Yang, T. Ikezoe, 2006, Cancer science.

Identifying progression‐associated genes in adult T‐cell leukemia/lymphoma by using oligonucleotide microarrays

Kazuhiro Nagai, Masao Tomonaga, H Phillip Koeffler, 2004, International journal of cancer.

ERCC5 is a novel biomarker of ovarian cancer prognosis.

Carl W. Miller, B. Karlan, S. Ogawa, 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Peroxisome proliferator-activated receptor gamma and cancers.

H. Koeffler, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Novel CUX1 missense mutation in association with 7q− at leukemic transformation of MPN

S. Ogawa, H. Koeffler, G. Kato, 2011, American journal of hematology.

Frequent pathway mutations of splicing machinery in myelodysplasia

S. Sugano, Yutaka Suzuki, S. Miyano, 2011, Nature.

Homozygous deletions of the p15 (MTS2) and p16 (CDKN2/MTS1) genes in adult T-cell leukemia.

M. Tomonaga, H. Koeffler, C. Miller, 1995, Blood.

Identification of three distinct regions of deletion on the long arm of chromosome 11 in childhood acute lymphoblastic leukemia

M. Schrappe, C. Bartram, H. Koeffler, 1999, Oncogene.

The role of the vitamin D endocrine system in health and disease.

H. Koeffler, A. Norman, H. Reichel, 1989, The New England journal of medicine.

1alpha,25-(OH)(2)-D(3) and its synthetic analogue decrease tumor load in the Apc(min) Mouse.

D. Heber, H. Koeffler, V. Go, 2002, Cancer research.

Human p53 gene localized to short arm of chromosome 17

Carl W. Miller, V. Rotter, T. Mohandas, 1986, Nature.

Deletions of the cyclin-dependent kinase inhibitor genes p16INK4A and p15INK4B in non-Hodgkin's lymphomas.

H. Koeffler, C. Miller, A. Gombart, 1995, Blood.

Structural integrity of the cyclin‐dependent kinase inhibitor genes, p15, p16 and p18 in myeloid leukaemias

Carl W. Miller, M. Fey, A. Tobler, 1995, British journal of haematology.

Role of the cyclin-dependent kinase inhibitors in the development of cancer.

H. Koeffler, H. Koeffler, T. Hirama, 1995, Blood.

Inhibition of growth of human leukemia cell lines by retrovirally expressed wild-type p16INK4A

H. Koeffler, A. Gombart, R. Yang, 1997, Leukemia.

Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-κB signal pathways

Yang Yang, H. Koeffler, Yang Yang, 2005, Molecular Cancer Therapeutics.

Methylation analysis of the adenomatous polyposis coli (APC) gene in adult T-cell leukemia/lymphoma.

H. Koeffler, Yang Yang, H. Taguchi, 2006, Leukemia research.

Identification of Interaction Partners and Substrates of the Cyclin A1-CDK2 Complex*

P. Ji, H. Koeffler, N. Bäumer, 2004, Journal of Biological Chemistry.

Quantum dot labeling and tracking of human leukemic, bone marrow and cord blood cells.

Laura Marcu, H Phillip Koeffler, Edward B Garon, 2007, Leukemia research.

TMEFF2 is an androgen-regulated gene exhibiting antiproliferative effects in prostate cancer cells

C. Sawyers, D. Agus, H. Koeffler, 2002, Oncogene.

Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays.

Motohiro Kato, Shigeru Chiba, Seishi Ogawa, 2007, American journal of human genetics.

Cyr61 Is Overexpressed in Gliomas and Involved in Integrin-Linked Kinase-Mediated Akt and β-Catenin-TCF/Lef Signaling Pathways

Dong Xie, Carl W. Miller, Dorina Gui, 2004, Cancer Research.

High-Resolution Genomic Copy Number Profiling of Glioblastoma Multiforme by Single Nucleotide Polymorphism DNA Microarray

Martin Dugas, Keith L. Black, Motohiro Kato, 2009, Molecular Cancer Research.

Tumor suppressor genes in normal and malignant hematopoiesis

A. Ganser, H. Koeffler, U. Krug, 2002, Oncogene.

Mutational Landscape of Pediatric Acute Lymphoblastic Leukemia.

S. Miyano, S. Ogawa, D. Liang, 2017, Cancer research.

Changes of DNA methylation and chromatin structure in the human myeloperoxidase gene during myeloid differentiation.

M. Lübbert, H. Koeffler, C. Miller, 1991, Blood.

Histone deacetylase inhibitors induce growth arrest and apoptosis of HTLV-1-infected T-cells via blockade of signaling by nuclear factor κB

H. Koeffler, N. Komatsu, T. Ikezoe, 2008 .

Fludarabine induces apoptosis of human T-cell leukemia virus type 1-infected T cells via inhibition of the nuclear factor-κB signal pathway

H. Koeffler, H. Taguchi, C. Nishioka, 2007, Leukemia.

Expression and regulation of myeloid-specific genes in normal and leukemic myeloid cells.

F. Herrmann, M. Lübbert, H. Koeffler, 1991, Blood.

Breast Cancer

Carl W. Miller, J. Gornbein, H. Koeffler, 2001, The Journal of Biological Chemistry.

HIV-1 protease inhibitor induces growth arrest and apoptosis of human multiple myeloma cells via inactivation of signal transducer and activator of transcription 3 and extracellular signal-regulated kinase 1/2.

H. Koeffler, Yang Yang, T. Ikezoe, 2004, Molecular cancer therapeutics.

The Cyclin A1-CDK2 Complex Regulates DNA Double-Strand Break Repair

Conrad A. Nieduszynski, L. Wiesmüller, W. Colledge, 2004, Molecular and Cellular Biology.

C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters.

A. Chumakov, H. Koeffler, A. Friedman, 1999, Blood.

Human myeloid leukemia cell lines: a review.

H. Koeffler, D. Golde, 1980, Blood.

PC-SPES: a potent inhibitor of nuclear factor-kappa B rescues mice from lipopolysaccharide-induced septic shock.

D. Heber, H. Koeffler, Yang Yang, 2003, Molecular pharmacology.

Analysis of p53 transactivation through high-affinity binding sites.

A. Chumakov, H. Koeffler, C. Miller, 1993, Oncogene.

Mutant p53 proteins behave in a dominant, negative fashion in vivo.

A. Chumakov, H. Koeffler, C. Miller, 1994, Anticancer research.

Recombinant human tumor necrosis factor alpha regulates c-myc expression in HL-60 cells at the level of transcription.

A. Tobler, H. Koeffler, D. Johnston, 1987, Blood.

Recombinant human tumor necrosis factor alpha regulates c-myc expression in HL-60 cells at the level of transcription.

A. Tobler, H. Koeffler, D. Johnston, 1987, Blood.

15-hydroxyprostaglandin dehydrogenase is a tumor suppressor of human breast cancer.

B. Karlan, H. Tai, H. Koeffler, 2006, Cancer research.

The production of IL‐8 in cerebrospinal fluid in aseptic meningitis of children

H. Koeffler, A. Komiyama, A. Ishiguro, 1997, Clinical and experimental immunology.

Immunotherapy against murine leukemia

H. Koeffler, D. Kohn, S. Vos, 1998, Leukemia.

Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells.

H. Koeffler, S. Tomoyasu, M. Uskoković, 2001, Blood.

Chronic myelogenous leukemia--new concepts (second of two parts).

H. Koeffler, D. Golde, 1981, The New England journal of medicine.

Compound 48, a novel dual PPAR alpha/gamma ligand, inhibits the growth of human CML cell lines and enhances the anticancer-effects of imatinib.

H. Koeffler, K. Possinger, Hongyu Liu, 2009, Leukemia research.

Expression of the candidate Wilm's tumor gene, WT1, in human leukemia cells.

H. Koeffler, I. Miyoshi, I. Kubonishi, 1993, Leukemia.

Acute myelogenous leukemia: a human cell line responsive to colony-stimulating activity.

H. Koeffler, D. Golde, 1978, Science.

Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis

W. Sly, B. Bacon, H. Koeffler, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Phenotypic and functional alterations of peripheral blood monocytes in neutrophil‐specific granule deficiency

H. Koeffler, A. Komiyama, A. Gombart, 2004, Journal of leukocyte biology.

Insulin-like growth factor binding protein-3 antagonizes the effects of retinoids in myeloid leukemia cells.

P. Cohen, H. Koeffler, T. Ikezoe, 2004, Blood.

In vitro interaction of recombinant tumor necrosis factor alpha and all-trans-retinoic acid with normal and leukemic hematopoietic cells.

D. Heitjan, A. Tobler, H. Koeffler, 1987, Blood.

Regulation of levels of IL‐1 mRNA in human fibroblasts

H. Koeffler, K. Yamato, Z. el-Hajjaoui, 1989, Journal of cellular physiology.

Connective Tissue Growth Factor Is Overexpressed in Esophageal Squamous Cell Carcinoma and Promotes Tumorigenicity through β-Catenin-T-cell Factor/Lef Signaling*

D. Xie, H. Koeffler, Baojie Li, 2007, Journal of Biological Chemistry.

Cyr61, a Member of CCN Family, Is a Tumor Suppressor in Non-Small Cell Lung Cancer*

Carl W. Miller, D. Xie, H. Koeffler, 2001, The Journal of Biological Chemistry.

Colony Stimulating Factors: Regulation of Production

H. Koeffler, M. Akashi, 1992 .

Expression of hematopoietic growth factor RNAs in human mesenchymal cells from various organs.

H. Koeffler, K. Yamato, Z. el-Hajjoui, 1991, Leukemia research.

A Novel, Myeloid Transcription Factor, C/EBPε, Is Upregulated During Granulocytic, But Not Monocytic, Differentiation

K. Weinberg, A. Chumakov, H. Koeffler, 1997 .

A novel, myeloid transcription factor, C/EBP epsilon, is upregulated during granulocytic, but not monocytic, differentiation.

K. Weinberg, A. Chumakov, H. Koeffler, 1997, Blood.

Localization of Kaposi's sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myeloma.

G. Pinkus, H. Koeffler, J. Said, 1997 .

Modulation of mRNA expression of a novel human myeloid-selective CCAAT/enhancer binding protein gene (C/EBP epsilon).

A. Chumakov, A. Silla, H. Koeffler, 1997, Blood.

A new series of vitamin D analogs is highly active for clonal inhibition, differentiation, and induction of WAF1 in myeloid leukemia.

Wei Zhang, M. Andreeff, H. Koeffler, 1996, Blood.

Rearrangement of the p53 gene in human osteogenic sarcomas.

H. Koeffler, H. Battifora, M. Cline, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Recombinant human TNF alpha stimulates production of granulocyte colony- stimulating factor

H. Koeffler, J. Gasson, R. Munker, 1987 .

p53 mutations in human lung tumors.

J. Yokota, K. Kok, K. Simon, 1992, Cancer research.

A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemia

Taizo Tasaka, H Phillip Koeffler, H. Koeffler, 2007, Molecular Cancer Therapeutics.

Analysis of Aurora B kinase in non-Hodgkin lymphoma

M. Furihata, H. Koeffler, T. Ikezoe, 2009, Laboratory Investigation.

A novel treatment strategy targeting polo-like kinase 1 in hematological malignancies

H. Koeffler, T. Ikezoe, Jing Yang, 2009, Leukemia.

Tumor necrosis factor α: Posttranscriptional stabilization of WAF1 mRNA in p53‐deficient human leukemic cells

H. Koeffler, M. Akashi, A. Gombart, 1996 .

P53 mutations in human cancer.

H P Koeffler, H. Koeffler, C. Miller, 1993, Leukemia.

Localization of p53 protein and human papillomavirus in anogenital squamous lesions: immunohistochemical and in situ hybridization studies in benign, dysplastic, and malignant epithelia.

H. Koeffler, J. Said, A. Walts, 1993, Human pathology.

Expression, methylation and chromatin structure of the p53 gene in untransformed and human T-cell leukemia virus type I-transformed human T-lymphocytes.

M. Lübbert, H. Koeffler, C. Miller, 1989, Oncogene.

Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBPϵ

H Phillip Koeffler, H. Koeffler, A. Gombart, 2002, Current opinion in hematology.

A Novel In-Frame Deletion in the Leucine Zipper Domain of C/EBPε Leads to Neutrophil-Specific Granule Deficiency

T. Yokota, H. Koeffler, T. Akagi, 2015, The Journal of Immunology.

Neutrophil-Specific Granule Deficiency Leads to ε Zipper Domain of C / EBP A Novel In-Frame Deletion in the Leucine

T. Yokota, H. Koeffler, T. Akagi, 2015 .

Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor

A. Chumakov, H. Koeffler, J. Slater, 1997, Molecular and cellular biology.

Identification of Transcriptional Activation and Repression Domains in Human CCAAT/Enhancer-binding Protein ε*

A. Chumakov, E. Williamson, H. Koeffler, 1998, The Journal of Biological Chemistry.

Myeloid transcription factor C/EBPepsilon is involved in the positive regulation of lactoferrin gene expression in neutrophils.

H. Koeffler, D. Park, Dorothy J. Park, 1999, Blood.

Myeloid Transcription Factor C/EBPɛ Is Involved in the Positive Regulation of Lactoferrin Gene Expression in Neutrophils

H. Koeffler, Dorothy J. Park, P. T. Vuong, 1999 .

Representational difference analysis using myeloid cells from C/EBPε deletional mice

A. Chumakov, H. Koeffler, H. Taguchi, 2000 .

Representational difference analysis using myeloid cells from C/EBP epsilon deletional mice.

A. Chumakov, H. Koeffler, H. Taguchi, 2000, Blood.

Long-term study of the clinical significance of loss of heterozygosity in childhood acute lymphoblastic leukemia

M. Schrappe, H. Koeffler, H. Taguchi, 2003, Leukemia.

Acute lymphoblastic leukemia of childhood: identification of two distinct regions of deletion on the short arm of chromosome 12 in the region of TEL and KIP1.

M. Schrappe, C. Bartram, H. Koeffler, 1996, Blood.

Clinical significance of aberrant DNA methylation in childhood acute lymphoblastic leukemia.

M. Schrappe, C. Bartram, H. Koeffler, 2011, Leukemia research.

Dominant-Negative Mechanism of Leukemogenic PAX5 Fusions

A. Berk, H. Koeffler, M. Pennella, 2011, Oncogene.

Comparative Analysis of Genes Regulated by PML/RARα and PLZF/RARα in Response to Retinoic Acid Using Oligonucleotide Arrays

H. Koeffler, Dorothy J. Park, P. T. Vuong, 2003 .

HIV-1 Protease Inhibitor, Ritonavir

Y. Ohtsuki, H. Koeffler, Yang Yang, 2004, Cancer Research.

Is there a role for differentiating therapy in non-APL AML?

H. Koeffler, 2010, Best practice & research. Clinical haematology.

Molecular allelokaryotyping of early‐stage, untreated chronic lymphocytic leukemia

S. Ogawa, S. Lehmann, M. Sanada, 2008, Cancer.

Chronic myelogenous leukemia--new concepts (first of two parts).

H. Koeffler, D. Golde, 1981, The New England journal of medicine.

Erythropoietin radioimmunoassay in evaluating patients with polycythemia.

H. Koeffler, E. Goldwasser, 1981, Annals of internal medicine.

Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers.

M. Tomonaga, H. Koeffler, C. Miller, 2001, Cancer research.

Preadipocytes stimulate breast cancer cell growth.

D. Heber, H. Koeffler, E. Elstner, 1998, Nutrition and cancer.

Mutation Found in Breast Cancer 1

H. Koeffler, K. Spirin, N. Kawamata, 2006 .

Allelic loss during progression of follicular lymphoma.

S. de Vos, T. Grogan, H. Koeffler, 2004, Leukemia research.

Baicalin is a major component of PC‐SPES which inhibits the proliferation of human cancer cells via apoptosis and cell cycle arrest

D. Heber, H. Koeffler, T. Ikezoe, 2001, The Prostate.

Frequent Loss of Heterozygosity on Chromosomes 6q, 9p, 11q or 12p in Childhood Acute Lymphoblastic Leukemia

Carl W. Miller, T. Golub, D. Gilliland, 1998 .

Mutation and expression analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in pituitary tumors.

S. Melmed, H. Koeffler, I. Shimon, 1998, The Journal of endocrinology.

Alterations of the p15, p16,and p18 genes in osteosarcoma.

H. Koeffler, C. Miller, N. Kawamata, 1996, Cancer genetics and cytogenetics.

Molecular analysis of the cyclin‐dependent kinase inhibitor family: p16(CDKN2/MTS1/INK4A), p18(INK4C) and p27(Kip1) genes in neuroblastomas

C. Bartram, H. Koeffler, N. Kawamata, 1996, Cancer.

p27/Kipl Mutation Found in Breast Cancer1

H. Koeffler, N. Kawamata, J. Simpson, 1996 .

Allelotype analysis of childhood acute lymphoblastic leukemia.

C. Bartram, H. Koeffler, C. Miller, 1995, Cancer research.

Alterations of the p27KIP1 gene in non-Hodgkin's lymphomas and adult T-cell leukemia/lymphoma.

M. Tomonaga, H. Koeffler, C. Miller, 1995, Blood.

Molecular analysis of a family of cyclin‐dependent kinase inhibitor genes (p15/MTS2/INK4b and p18/INK4c) in non‐small cell lung cancers

Carl W. Miller, H. Koeffler, C. Miller, 1995, Molecular carcinogenesis.

Deregulated Intracellular Signaling by Mutated c-CBL in Myeloid Neoplasms

S. Ogawa, H. Nakauchi, L. Shih, 2010, Clinical Cancer Research.

Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms

Masao Nagasaki, Satoru Miyano, Yuichi Shiraishi, 2012, Nature Genetics.

Dual PPARα/γ Ligand TZD18 Either Alone or in Combination with Imatinib Inhibits Proliferation and Induces Apoptosis of Human CML Cell Lines

H. Koeffler, K. Possinger, Hongyu Liu, 2006, Cell cycle.

1 alpha,25-Dihydroxyvitamin D3 inhibits gamma-interferon synthesis by normal human peripheral blood lymphocytes.

A. Tobler, H. Koeffler, A. Norman, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Primary effusion lymphoma in women: report of two cases of Kaposi's sarcoma herpes virus-associated effusion-based lymphoma in human immunodeficiency virus-negative women.

S. de Vos, E. Cesarman, Jonathan, 1996, Blood.

Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis.

C. Camargo, I. Bhan, H. Koeffler, 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

RARβ2 is a candidate tumor suppressor gene in myelofibrosis with myeloid metaplasia

W. Hofmann, H. Koeffler, A. Tefferi, 2004, Oncogene.

Lynch syndrome among gynecologic oncology patients meeting Bethesda guidelines for screening.

B. Karlan, R. Alsabeh, H. Koeffler, 2010, Gynecologic oncology.

p53 mutations in HPV-negative cervical carcinoma.

H. Koeffler, D. Park, C. Miller, 1994, Oncogene.

promyelocytic leukemia (APL) based on genomic alterations Hidden abnormalities and novel classification of t(15;17) acute

Carl W. Miller, S. Ogawa, D. Liang, 2013 .

Study of Differentiation and Proliferation of Leukemic Cells Using Myeloid Leukemia Cell Lines

H. Koeffler, 1985 .

A potential transcriptional activation element in the p53 protein.

C. Dang, K. Simon, H. Koeffler, 1990, Oncogene.

Reprogramming of m6A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia

K. Hu, H. Koeffler, D. Yin, 2020, RNA biology.

Receptor-targeted quantum dots: fluorescent probes for brain tumor diagnosis.

M. Gundersen, H. Koeffler, P. Vernier, 2007, Journal of biomedical optics.

Integrative analyses of transcriptome sequencing identify novel functional lncRNAs in esophageal squamous cell carcinoma

E. Li, H. Koeffler, X Li, 2017, Oncogenesis.

Characterization of a novel HTLV-infected cell line.

H. Koeffler, D. Golde, I. Chen, 1984, Blood.

Mutation of the p53 gene in neuroblastoma and its relationship with N-myc amplification.

F. Berthold, C. Bartram, H. Koeffler, 1993, Cancer research.

Frequent loss of heterozygosity in region of the KIP1 locus in non-small cell lung cancer: evidence for a new tumor suppressor gene on the short arm of chromosome 12.

H. Koeffler, C. Miller, J. Slater, 1996, Cancer research.

Proliferation and Differentiation In Vitro Effects of Novel RAR- and RXR-Selective Retinoids on Myeloid Leukemic

H. Koeffler, M. Dawson, K. Koike, 2010 .

Alterations of the ~ 2 7 ~ ' ' ' Gene in Non-Hodgkin ' s Lymphomas and Adult T-Cell Leukemia / Lymphoma

Carl W. Miller, H. Koeffler, N. Kawamata, 2002 .

Deletions of the Cyclin-Dependent Kinase Inhibitor Genes p 161 NK 4 * and ~ 1 5 ' ~ ~ ~ ~ in Non-Hodgkin ' s Lymphomas

Carl W. Miller, H. Koeffler, A. Gombart, 2000 .

Vitamin D analogs, leukemia and WAF1.

H. Koeffler, E. Elstner, R. Munker, 1998, Leukemia & lymphoma.

19-nor-hexafluoride analogue of vitamin D3: a novel class of potent inhibitors of proliferation of human breast cell lines.

H. Koeffler, N. Tsuruoka, M. Uskoković, 1997, Cancer research.

20-epi-vitamin D3 analogues: a novel class of potent inhibitors of proliferation and inducers of differentiation of human breast cancer cell lines.

S. de Vos, D. Heber, H. Koeffler, 1995, Cancer research.

p 53 in Hematologic Malignancies

H. Koeffler, 2002 .

Induction of endoplasmic reticulum stress response by TZD18, a novel dual ligand for peroxisome proliferator-activated receptor α/γ, in human breast cancer cells

H. Koeffler, K. Possinger, Hongyu Liu, 2009, Molecular Cancer Therapeutics.

HHV‐8 (KSHV) does not establish latency in prostate cancer cell lines

Carl W. Miller, H. Koeffler, Dorothy J. Park, 1997, The Prostate.

Is Kaposi's sarcoma--associated herpesvirus ubiquitous in urogenital and prostate tissues?

H. Koeffler, D. Park, J. Takahara, 1997, Blood.

Detection and titration of human herpesvirus-8-specific antibodies in sera from blood donors, acquired immunodeficiency syndrome patients, and Kaposi's sarcoma patients using a whole virus enzyme-linked immunosorbent assay.

M. Kaplan, A. Hamilton, H. Koeffler, 1998, Blood.

Growth inhibition of DU-145 prostate cancer cells by a Bcl-2 antisense oligonucleotide is enhanced by N-(2-hydroxyphenyl)all-trans retinamide.

H. Koeffler, M. Dawson, M. Campbell, 1998, British Journal of Cancer.

Vitamin D receptor: no evidence for allele-specific mRNA stability in cells which are heterozygous for the Taq I restriction enzyme polymorphism.

H. Koeffler, A. Gombart, M. Campbell, 1997, Biochemical and biophysical research communications.

mdm‐2 Oncogene Expression in Non‐Hodgkin's Lymphomas

Carl W. Miller, H. Koeffler, C. Miller, 1996, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint

T. Graeber, A. Melnick, B. Titz, 2013, Nature Medicine.

Seroprevalence of HHV-8 antibodies in HIV-positive homosexual men without Kaposi's sarcoma and their clinical follow-up.

H. Koeffler, J. Said, W. Verbeek, 1998, American journal of clinical pathology.

Is Kaposi's Sarcoma–Associated Herpesvirus Ubiquitous in Urogenital and Prostate Tissues?

H. Koeffler, J. Takahara, Dorothy J. Park, 1997 .

AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo.

H. Koeffler, N. Komatsu, T. Ikezoe, 2007, Blood.

Vitamin D: myeloid differentiation and proliferation.

H. Koeffler, 1985, Haematology and blood transfusion.

DNA hypermethylation of myeloid cells, a novel therapeutic target in MDS and AML.

M. Lübbert, H. Koeffler, B. Rüter, 2006, Current pharmaceutical biotechnology.

SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations.

S. Ogawa, A. Kohlmann, T. Haferlach, 2010, Blood.

Amendment history : Erratum ( November 2012 ) C / EBP e mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice

H. Koeffler, George Y. Liu, W. Berdel, 2018 .

is critical for the development of a diverse primary B cell repertoire.

A. Melnick, H. Jäck, B. H. Ye, 2010 .

BCL6 is critical for the development of a diverse primary B cell repertoire

A. Melnick, H. Jäck, B. H. Ye, 2009, The Journal of experimental medicine.

Inhibition of proliferation of prostate cancer cells by a 19-nor-hexafluoride vitamin D3 analogue involves the induction of p21waf1, p27kip1 and E-cadherin.

M. Campbell, H. Koeffler, M. Uskoković, 1997, Journal of molecular endocrinology.

Hematopoietic progenitor cells of transgenic mice with increased copper/zinc‐superoxide dismutase activity are resistant to tumor necrosis factor

C. Epstein, H. Koeffler, E. Carlson, 1994, Journal of cellular physiology.

Myeloid haemopoietic cells of patients with chronic granulomatous disease are relatively resistant to TNF

H. Koeffler, J. Curnutte, A. Sakashita, 1994, British journal of haematology.

HIV-1 protease inhibitors decrease proliferation and induce differentiation of human myelocytic leukemia cells.

E. Daar, H. Koeffler, H. Taguchi, 2000, Blood.

Carriers Leukemia / Lymphoma in Human T-lymphotropic Virus Type 1 Increased Susceptibility to Development of Adult T-Cell Polymorphism Associated with α Tumor Necrosis Factor

Carl W. Miller, M. Tomonaga, H. Koeffler, 2001 .

Retinoic acid. Inhibition of the clonal growth of human myeloid leukemia cells.

H. Koeffler, D. Douer, 1982, The Journal of clinical investigation.

p53 in hematologic malignancies.

H. Koeffler, I. Miyoshi, J. Imamura, 1994, Blood.

HIV-1 Protease Inhibitor , Ritonavir : A Potent Inhibitor of CYP 3 A 4 , Enhanced the Anticancer Effects of Docetaxel in Androgen-Independent Prostate Cancer Cells In vitro and In vivo

Y. Ohtsuki, H. Koeffler, Yang Yang, 2004 .

Tumor necrosis factor: receptors on hematopoietic cells.

J. Dipersio, H. Koeffler, H. Koeffler, 1987, Blood.

Induction of macrophage differentiation of human normal and leukemic myeloid stem cells by 1,25-dihydroxyvitamin D3 and its fluorinated analogues.

H. DeLuca, H. Koeffler, N. Ikekawa, 1984, Cancer research.

Absence of R24C Mutation of the CDK4 Gene in Leukemias and Solid Tumors

Carl W. Miller, H. Koeffler, H. Mizoguchi, 2003, International journal of hematology.

Pattern of expression of HLA-DR and HLA-DQ antigens and mRNA in myeloid differentiation.

H. Koeffler, T. Amatruda, J. Ranyard, 1987, Blood.

Regulation of manganese superoxide dismutase and other antioxidant genes in normal and leukemic hematopoietic cells and their relationship to cytotoxicity by tumor necrosis factor.

H. Koeffler, A. Karmakar, M. Kizaki, 1993, Blood.

1,25-Dihydroxyvitamin D3 receptor RNA: expression in hematopoietic cells.

H. Koeffler, A. Karmakar, M. Kizaki, 1991, Blood.

Modulation of interleukin-1 beta RNA in monocytic cells infected with human immunodeficiency virus-1.

K. Simon, H. Koeffler, K. Yamato, 1990, The Journal of clinical investigation.

with Human Immunodeficiency Virus-1

K. Simon, H. Koeffler, K. Yamato, 1990 .

Lipopolysaccharide from Actinobacillus actinomycetemcomitans stimulates macrophages to produce interleukin-1 and tumor necrosis factor mRNA and protein.

K. Simon, H. Koeffler, F. R. Saglie, 2007, Oral microbiology and immunology.

Alterations of differentiation, clonal proliferation, cell cycle progression and bcl-2 expression in RARα-altered sublines of HL-60

H. Koeffler, T. Umiel, E. Elstner, 1997, Leukemia.

Identified hidden genomic changes in mantle cell lymphoma using high-resolution single nucleotide polymorphism genomic array.

Reiner Siebert, Seishi Ogawa, H Phillip Koeffler, 2009, Experimental hematology.

Kaposi's sarcoma-associated herpesvirus (KSHV or HHV8) in primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells.

S. de Vos, E. Cesarman, H. Koeffler, 1996, Blood.

gamma-Interferon stimulates production of 1,25-dihydroxyvitamin D3 by normal human macrophages.

H. Koeffler, A. Norman, H. Reichel, 1985, Biochemical and biophysical research communications.

Somatic cell hybrid analyses of hematopoietic differentiation

H. Koeffler, G. Klein, R. Sparkes, 1981 .

Somatic cell hybrid analyses of hematopoietic differentiation.

H. Koeffler, G. Klein, R. Sparkes, 1981, Blood.

Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma

T. Haritunians, H. Koeffler, F. Giles, 2007, Leukemia.

Molecular genetic advances in chronic myelogenous leukemia.

H. Koeffler, D. Epner, Daniel Epner, 1990, Annals of internal medicine.

Novel Gemini-vitamin D3 analog inhibits tumor cell growth and modulates the Akt/mTOR signaling pathway

J. Vadgama, H. Koeffler, M. Uskoković, 2006, The Journal of Steroid Biochemistry and Molecular Biology.

The cellular response to PPARgamma ligands is related to the phenotype of neuroblastoma cell lines.

H. Koeffler, G. Scambia, C. Ferlini, 2004, Oncology research.

Mechanisms of retinoid resistance in leukemic cells: possible role of cytochrome P450 and P-glycoprotein.

H. Koeffler, M. Kizaki, Y. Ikeda, 1996, Blood.

Synthesis in vitro of 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 by interferon-gamma-stimulated normal human bone marrow and alveolar macrophages.

H. Koeffler, A. Norman, H. Reichel, 1987, The Journal of biological chemistry.

1,25-Dihydroxyvitamin D3: in vivo and in vitro effects on human preleukemic and leukemic cells.

H. Koeffler, K. Hirji, L. Itri, 1985, Cancer treatment reports.

Gamma-interferon induces expression of the HLA-D antigens on normal and leukemic human myeloid cells.

H. Koeffler, J. Ranyard, R. Bohman, 1984, Proceedings of the National Academy of Sciences of the United States of America.

An AKI biomarker lipocalin 2 in the blood derives from the kidney in renal injury but from neutrophils in normal and infected conditions

K. Nakao, J. Kanda, H. Koeffler, 2015, Clinical and Experimental Nephrology.

C/EBPδ expression in a BCR-ABL-positive cell line induces growth arrest and myeloid differentiation

W. Hofmann, H. Koeffler, S. Gery, 2005, Oncogene.

Older patients with normal karyotype acute myeloid leukemia have a higher rate of genomic changes compared to young patients as determined by SNP array analysis.

S. Ogawa, T. Haferlach, A. Nagler, 2012, Leukemia research.

Co-infection of HHV-6 and HHV-8 is rare in primary effusion lymphoma.

N. Kamada, H. Koeffler, J. Said, 2000, Leukemia research.

Regulation of 1,25-dihydroxyvitamin D3 production by cultured alveolar macrophages from normal human donors and from patients with pulmonary sarcoidosis.

H. Koeffler, A. Norman, H. Reichel, 1987, The Journal of clinical endocrinology and metabolism.

HIV-1 protease inhibitor ritonavir potentiates the effect of 1,25-dihydroxyvitamin D3 to induce growth arrest and differentiation of human myeloid leukemia cells via down-regulation of CYP24.

H. Koeffler, Yang Yang, T. Ikezoe, 2006, Leukemia research.

p 53 Mutations in Human Lung Tumors 1

Carl W. Miller, J. Yokota, K. Kok, 2006 .

Saw Palmetto induces growth arrest and apoptosis of androgen-dependent prostate cancer LNCaP cells via inactivation of STAT 3 and androgen receptor signaling.

H. Koeffler, Wei-Guo Zhu, Zhixing Zheng, 2007, International journal of oncology.

Prevalence of N-ras mutations in children with myelodysplastic syndromes and acute myeloid leukemia.

F. McCormick, F. Herrmann, R. Mertelsmann, 1992, Oncogene.

A mouse model for vitamin D-induced human cathelicidin antimicrobial peptide gene expression

H. Koeffler, A. Gombart, A. Indra, 2019, The Journal of Steroid Biochemistry and Molecular Biology.

Differentiation therapy in myelodysplastic syndromes.

H. Koeffler, R. Morosetti, 1996, Seminars in hematology.

Vitamin D3 analogs: effect on leukemic clonal growth and differentiation, and on serum calcium levels.

S. de Vos, H. Koeffler, M. Uskoković, 1995, Leukemia research.

Identification of murine and human XCP1 genes as C/EBP-ε-dependent members of FIZZ/Resistin gene family

A. Chumakov, H. Koeffler, S. Walter, 2004, Oncogene.

Id2 expression increases with differentiation of human myeloid cells.

M. Israel, A. Tobler, H. Koeffler, 1996, Blood.

Mutation analysis of transferrin-receptor 2 in patients with atypical hemochromatosis.

W. Hofmann, H. Koeffler, J. Kushner, 2002, Blood.

CXCR 4 expression is associated with survival in familial chronic lymphocytic leukemia , but CD 38 expression

W. Hofmann, H. Koeffler, J. Kushner, 2002 .

Antigens present on human myeloid leukemia cell lines.

H. Koeffler, D. Golde, R. Sparkes, 1980, Leukemia research.

Human myeloid precursors forming colonies in diffusion chambers expresses the Ia-like antigen.

H. Koeffler, D. Golde, M. Cline, 1979, Blood.

C/EBPα and the Vitamin D Receptor Cooperate in the Regulation of Cathelicidin in Lung Epithelial Cells

P. Dhawan, H. Koeffler, A. Gombart, 2015, Journal of cellular physiology.

Methylation of the MLH1 gene in hematological malignancies.

H. Koeffler, Yang Yang, H. Taguchi, 2005, Oncology reports.

Allelotype analysis in the evolution of chronic myelocytic leukemia.

H. Koeffler, H. Mizoguchi, G. Schiller, 1997, Blood.

Adaptor Protein Lnk Inhibits C-Fms Mediated Macrophage Function

H. Koeffler, S. Gery, H. Goodridge, 2008 .

H. Koeffler, D. Park, H. Koeffler, 1992, Hematology/oncology clinics of North America.

Kaposi's sarcoma-associated herpesvirus and human herpesvirus 8 (KSHV/HHV8)-associated lymphoma of the bowel. Report of two cases in HIV-positive men with secondary effusion lymphomas.

S. de Vos, E. Cesarman, H. Koeffler, 1997, The American journal of surgical pathology.

Ovarian Cancer: Loss of Heterozygosity Frequently Occurs in the ATM Gene, but Structural Alterations Do Not Occur in This Gene

J. Yokota, H. Koeffler, N. Tsuruoka, 1999, Oncology.

The PPARγ ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines

G. Maira, S. Rutella, H. Koeffler, 2004 .

The PPARgamma ligands PGJ2 and rosiglitazone show a differential ability to inhibit proliferation and to induce apoptosis and differentiation of human glioblastoma cell lines.

G. Maira, S. Rutella, H. Koeffler, 2004, International journal of oncology.

1,25-Dihydroxyvitamin D 3 -induced Differentiation in a Human Promyelocytic Leukemia Cell Line (HL-60) : Receptor-mediated Maturation to Macrophage-like Cells

M. Haussler, D. Mangelsdorf, H. Koeffler, 2002 .

1,25-Dihydroxyvitamin D3 modulates the expression of a lymphokine (granulocyte-macrophage colony-stimulating factor) posttranscriptionally.

A. Tobler, H. Koeffler, C. Miller, 1988, The Journal of clinical investigation.

Carcinoma of the vulva: HPV and p53 mutations.

A. Chumakov, H. Koeffler, Y. Y. Lee, 1994, Oncogene.

Secondary myelodysplastic syndromes and leukemias.

H. Koeffler, F. Giles, 1994, Current opinion in hematology.

Novel Gemini vitamin D3 analogs have potent antitumor activity

T. Haritunians, H. Koeffler, R. Okamoto, 2008, The Journal of Steroid Biochemistry and Molecular Biology.

Characterization of a novel analogue of 1alpha,25(OH)(2)-vitamin D(3) with two side chains: interaction with its nuclear receptor and cellular actions.

H. Koeffler, M. Uskoković, J. Hisatake, 2000, Journal of medicinal chemistry.

Ia antigen is a differentiation marker on human eosinophils.

A. Levine, H. Koeffler, D. Golde, 1980, Blood.

Regulation of 25-hydroxyvitamin D3 metabolism in a human promyelocytic leukemia cell line (HL-60): 1,25-dihydroxyvitamin D3 stimulates the synthesis of 24,25-dihydroxyvitamin D3.

H. Koeffler, A. Norman, H. Reichel, 1986, Archives of biochemistry and biophysics.

Phorbol ester effect on differentiation of human myeloid leukemia cell lines blocked at different stages of maturation.

H. Koeffler, M. Bar‐eli, M. Territo, 1981, Cancer research.

Induction by Phorbol Esters of Macrophage Differentiation in Human Leukaemia Cell Lines does not Require Cell Division

H. Koeffler, M. Territo, Mary C. Territo, 1981, British journal of haematology.

Phorbol diester-induced macrophage differentiation of leukemic blasts from patients with human myelogenous leukemia.

H. Koeffler, M. Bar‐eli, M. Territo, 1980, The Journal of clinical investigation.

Retinoic acid enhances colony-stimulating factor-induced clonal growth of normal human myeloid progenitor cells in vitro.

H. Koeffler, D. Douer, 1982, Experimental cell research.

Retrospective analysis of ras gene activation in myeloid leukemic cells.

F. McCormick, F. Herrmann, R. Mertelsmann, 1990, Oncogene.

Immunohistochemical analysis of p53 expression in malignant lymphomas.

H. Koeffler, J. Said, I. Shintaku, 1992, The American journal of pathology.

A nonsense mutation of IDH1 in myelodysplastic syndromes and related disorders

S. Ogawa, M. Sanada, H. Koeffler, 2011, Leukemia.

Erythropoiesis in preleukemia.

H. Koeffler, D. Golde, M. Cline, 1978, Blood.

Myelodysplastic syndrome.

W. Hofmann, H. Koeffler, Helen E. Heslop, 2005, Annual review of medicine.

Koeffler therapeutic implications Induction of differentiation of human acute myelogenous leukemia cells

H. Koeffler, 2005 .

Specific binding of [3H]phorbol dibutyrate to phorbol diester-responsive and -resistant clones of a human myeloid leukemia (KG-1) line 1.

H. Koeffler, R. Lehrer, L. Cohen, 1983, Cancer research.

bone mobilization differentiation with little effect on either intestinal calcium absorption or Novel vitamin D analogs that modulate leukemic cell growth and

H. Koeffler, A. Norman, E. D. Collins, 2011 .

Novel vitamin D analogs that modulate leukemic cell growth and differentiation with little effect on either intestinal calcium absorption or bone mobilization.

M. Lübbert, H. Koeffler, M. Uskoković, 1989, Blood.

Genome-Wide Analysis of MDS/MPD Disclosed Frequent Homozygous C-Cbl mutations Tightly Associated with 11q-UPD

S. Ogawa, Motohiro Kato, J. Takita, 2008 .

Retinoids. Structure-function relationship in normal and leukemic hematopoiesis in vitro.

A. Tobler, H. Koeffler, M. Dawson, 1986, The Journal of clinical investigation.

Retinoic acid enhances growth of human early erythroid progenitor cells in vitro.

H. Koeffler, D. Douer, 1982, The Journal of clinical investigation.

Mutations of the p53 gene in adult T-cell leukemia.

H. Koeffler, C. Miller, K. Takatsuki, 1992, Blood.

The emergence of a C/EBPα mutation in the clonal evolution of MDS towards secondary AML

A. Ganser, W. Hofmann, H. Koeffler, 2003, Leukemia.

C/EBP-β, C/EBP-δ, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies

Carl W. Miller, W. Hofmann, H. Koeffler, 2002 .

C/EBP-beta, C/EBP-delta, PU.1, AML1 genes: mutational analysis in 381 samples of hematopoietic and solid malignancies.

Carl W. Miller, W. Hofmann, H. Koeffler, 2002, Leukemia research.

Mutation and protein expression of p53 in acquired immunodeficiency syndrome-related lymphomas.

H. Koeffler, C. Miller, J. Said, 1993, Blood.

Homozygous Deletions of the p 15 ( MTS 2 ) and p 16 ( CDKN 2 / MTS 1 ) Genes in Adult T-cell Leukemia

M. Tomonaga, H. Koeffler, Yasuaki Yamada, 2000 .

Deletions of p15 and/or p16 genes as a poor-prognosis factor in adult T-cell leukemia.

M. Tomonaga, H. Koeffler, H. Hirai, 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Allelotyping of acute myelogenous leukemia: loss of heterozygosity at 7q31.1 (D7S486) and q33-34 (D7S498, D7S505).

H. Koeffler, N. Tsuruoka, M. Koike, 1999, Leukemia research.

leukemia identifies heterogeneous secondary genomic alterations SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid

S. Ogawa, A. Kohlmann, T. Haferlach, 2011 .

Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C/EBPbeta-deficient hematopoietic cells.

S. Akira, H. Koeffler, T. Akagi, 2008, Blood.

The correlation pattern of acquired copy number changes in 164 ETV6/RUNX1-positive childhood acute lymphoblastic leukemias.

S. Ogawa, B. Johansson, F. Mitelman, 2010, Human molecular genetics.

Aberrant methylation in promoter-associated CpG islands of multiple genes in relapsed childhood acute lymphoblastic leukemia.

J. V. van Dongen, C. Bartram, H. Koeffler, 2004, Oncology reports.

Hidden Abnormalities and Novel Classification of t(15;17) APL Based on Genomic Alterations.

Carl W. Miller, S. Ogawa, D. Liang, 2007 .

Specific interaction between adenoviral 55-kDa E1B protein and in vivo produced p53 fusion proteins.

A. Chumakov, H. Koeffler, 1993, Gene.

Aberrant methylation in promoter-associated CpG islands of multiple genes in therapy-related leukemia.

H. Koeffler, Yang Yang, S. Takeuchi, 2003, International journal of oncology.

1,25-Dihydroxy-16-ene-23-yne-vitamin D3 prolongs survival time of leukemic mice.

H. Koeffler, M. Uskoković, A. Norman, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Synergistic decrease of clonal proliferation, induction of differentiation, and apoptosis of acute promyelocytic leukemia cells after combined treatment with novel 20-epi vitamin D3 analogs and 9-cis retinoic acid.

John Calvin Reed, H. Koeffler, L. Binderup, 1997, The Journal of clinical investigation.

Myeloperoxidase: Its Structure and Expression During Myeloid Differentiation

H. Koeffler, M. Pertcheck, J. Ranyard, 1985 .

Myeloperoxidase: its structure and expression during myeloid differentiation.

H. Koeffler, M. Pertcheck, J. Ranyard, 1985, Blood.

Production of Interleukin-10 in the Cerebrospinal Fluid in Aseptic Meningitis of Children

H. Koeffler, A. Komiyama, A. Ishiguro, 1996, Pediatric Research.

Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia.

J. V. van Dongen, C. Bartram, W. Hofmann, 2006, Leukemia research.

Methylation analysis of asparagine synthetase gene in acute lymphoblastic leukemia cells

C. Bartram, W. Hofmann, H. Koeffler, 2006, Leukemia.

Dlk1 in normal and abnormal hematopoiesis

L. Shih, W. Hofmann, H. Koeffler, 2005, Leukemia.

The p19INK4D Cyclin dependent kinase inhibitor gene is altered in osteosarcoma

H. Koeffler, C. Miller, U. Aytac, 1997, Oncogene.

Alterations of the cyclin-dependent kinase inhibitor p19 (INK4D) is rare in hematopoietic malignancies.

M. Tomonaga, H. Koeffler, C. Miller, 1996, Leukemia.

Analysis of p16INK4a and its interaction with CDK4.

M. Serrano, E. Leung, H. Koeffler, 1996, Biochemical and biophysical research communications.

Granulocyte-macrophage colony-stimulating factor. Sensitive and receptor-mediated regulation by 1,25-dihydroxyvitamin D3 in normal human peripheral blood lymphocytes.

A. Tobler, H. Koeffler, A. Norman, 1987, The Journal of clinical investigation.

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells

M. Haussler, D. Mangelsdorf, H. Koeffler, 1984, The Journal of cell biology.

Transcriptional and posttranscriptional modulation of myeloid colony-stimulating factor expression by tumor necrosis factor and other agents

A. Tobler, H. Koeffler, J. Gasson, 1988, Molecular and cellular biology.

Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance.

S. Ogawa, Motohiro Kato, D. Nowak, 2015, Experimental hematology.

Allelotype analysis in relapsed childhood acute lymphoblastic leukemia

C. Bartram, J. Dongen, H. Koeffler, 2003, Oncogene.

Studies of vitamin D (calciferol) and its analogs. 39. Arocalciferols: synthesis and biological evaluation of aromatic side-chain analogs of 1.alpha.,25-dihydroxyvitamin D3

H. Koeffler, A. Norman, Jian-yuan Zhou, 1991 .

Differential Sensitivities of Malignant and Normal Skin Cells to Nanosecond Pulsed Electric Fields

M. Gundersen, H. Koeffler, P. Vernier, 2011, Technology in cancer research & treatment.

Vitamin D3 analogs inhibit growth and induce differentiation in LA-N-5 human neuroblastoma cells

H. Koeffler, Randal K. Wada, J. Yamashiro, 1996, Clinical & Experimental Metastasis.

CCAAT/enhancer binding protein epsilon: changes in function upon phosphorylation by p38 MAP kinase.

A. Chumakov, E. Williamson, H. Koeffler, 2005, Blood.

CCAAT / enhancer binding protein : changes in function upon phosphorylation by p 38 MAP kinase

A. Chumakov, E. Williamson, H. Koeffler, 2005 .

Genetic polymorphisms in the tumour necrosis factor locus in childhood acute lymphoblastic leukaemia

M. Schrappe, C. Bartram, H. Koeffler, 2002, British journal of haematology.

Retinoic acid treatment of human neuroblastoma cells is associated with decreased N-myc expression.

H. Koeffler, N. Sidell, T. Amatruda, 1985, Biochemical and biophysical research communications.

25-Hydroxyvitamin D3 metabolism by lipopolysaccharide-stimulated normal human macrophages.

H. Koeffler, A. Norman, H. Reichel, 1987, The Journal of clinical endocrinology and metabolism.

Alterations of the p53, Rb and MDM2 genes in osteosarcoma.

H. Koeffler, C. Miller, B. Lampkin, 1996, Journal of cancer research and clinical oncology.

Recombinant gibbon interleukin-3 acts synergistically with recombinant human G-CSF and GM-CSF in vitro.

H. Koeffler, R. Paquette, J. Zhou, 1988, Blood.

Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1.

H Phillip Koeffler, B. Torbett, H. Koeffler, 2003, Blood.

Structural and functional studies of CCAAT/enhancer-binding protein epsilon.

J. Tang, H. Koeffler, 2001, The Journal of biological chemistry.

Mutations of the p53 gene are not detectable in human testicular tumors.

D. Slamon, H. Koeffler, T. Strohmeyer, 1994, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

Novel vitamin D3 analog (CB1093) when combined with paclitaxel and cisplatin inhibit growth of MCF-7 human breast cancer cells in vivo.

H. Koeffler, L. Binderup, J. Said, 1998, International journal of oncology.

Effects of phorbol ester on translocation and down-regulation of protein kinase C and phosphorylation of endogenous proteins in human acute myeloid leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.

H. Koeffler, M. Shoji, J. Kuo, 1987, Cancer research.

Multiple mechanisms control the expression of granulocyte-macrophage colony-stimulating factor by human fibroblasts.

H. Koeffler, S. Nimer, J. Gasson, 1989, Journal of immunology.

Metabolism of 1α,25-dihydroxyvitamin D3 in human promyelocytic leukemia (HL-60) cells: In vitro biological activities of the natural metabolites of 1α,25-dihydroxyvitamin D3 produced in HL-60 cells

M. Campbell, H. Koeffler, M. Uskoković, 2001, Steroids.

Highly active analogs of 1α,25-dihydroxyvitamin D3 that resist metabolism through C-24 oxidation and C-3 epimerization pathways

M. Campbell, H. Koeffler, A. Takeuchi, 2001, Steroids.

Effect of homoharringtonine on proliferation and differentiation of human leukemic cells in vitro.

H. Koeffler, J. Zhou, D. L. Chen, 1990, Cancer research.

Synthesis and biological activities of the two C(23) epimers of 1α,23,25-trihydroxy-24-oxo-19-nor-vitamin D3: novel analogs of 1α,23(S),25-trihydroxy-24-oxo-vitamin D3, a natural metabolite of 1α,25-dihydroxyvitamin D3

M. Campbell, H. Koeffler, S. Peleg, 2000, Steroids.

Development of a novel 1,25(OH)2-vitamin D3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism.

H. Koeffler, M. Akashi, M. Uskoković, 1991, Blood.

Structure-Function Studies on Analogues of 1α,25-Dihydroxyvitamin D3: Differential Effects on Leukemic Cell Growth, Differentiation, and Intestinal Calcium Absorption

H. Koeffler, M. Uskoković, A. Norman, 1990 .

25-Hydroxyvitamin D3 metabolism by human T-lymphotropic virus-transformed lymphocytes.

H. Koeffler, A. Norman, H. Reichel, 1987, The Journal of clinical endocrinology and metabolism.

5,6-trans-16-ene-vitamin D3: a new class of potent inhibitors of proliferation of prostate, breast, and myeloid leukemic cells.

H. Koeffler, S. Tomoyasu, M. Uskoković, 1999, Cancer research.

Granulocyte-Macrophage Colony-stimulating Factor Sensitive and Receptor-mediated Regulation by 1 , 25-Dihydroxyvitamin D 3 in Normal Human Peripheral Blood Lymphocytes

A. Tobler, H. Koeffler, A. Norman, 2013 .

Granulocyte-macrophage colony-stimulating factor

H. Koeffler, A. Norman, H. Reichel, 1992 .

Molecular Cloning of Transferrin Receptor 2

H. Koeffler, P. T. Vuong, A. Gombart, 1999, The Journal of Biological Chemistry.

Membrane differentiation in human myeloid cells: expression of unique profiles of cell surface glycoproteins in myeloid leukemic cell lines blocked at different stages of differentiation and maturation.

H. Koeffler, M. Fukuda, J. Minowada, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Molecular analysis of the secretory phospholipase A2 gene, a candidate of Mom1 gene, in neuroblastomas.

C. Bartram, H. Koeffler, N. Kawamata, 1997, Cancer letters.

Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells.

D. Heber, H. Koeffler, T. Ikezoe, 2003, International journal of oncology.

Effect of 1,25-dihydroxyvitamin D3 and its analogs on human immunodeficiency virus infection in monocytes/macrophages.

K. Simon, H. Koeffler, M. Kizaki, 1993, Leukemia.

Granulocyte-macrophage colony-stimulating factor: signals for its mRNA accumulation.

H. Koeffler, K. Yamato, J. Kuo, 1989, Blood.

Cells of Proliferation of Prostate , Breast , and Myeloid Leukemic : A New Class of Potent Inhibitors 3-16-ene-Vitamin D trans 5 , 6-Updated

H. Koeffler, S. Tomoyasu, M. Uskoković, 1999 .

6-trans-16-ene-Vitamin D 3 : A New Class of Potent Inhibitors of Proliferation of Prostate , Breast , and Myeloid Leukemic Cells 1

H. Koeffler, S. Tomoyasu, M. Uskoković, 1999 .

SRSF2 is Mutated in 47.2% (77/163) of Chronic Myelomonocytic Leukemia (CMML) and Prognostically Favorable in Cases with Concomitant RUNX1 mutations

S. Ogawa, A. Kohlmann, T. Haferlach, 2011 .

The molecular biology of differentiation and proliferation using human myelogenous leukemia cells

H. Koeffler, C. Miller, Carlin Miller, 1986, BioEssays : news and reviews in molecular, cellular and developmental biology.

Human myelogenous leukemia: enhanced clonal proliferation in the presence of phorbol diesters.

H. Koeffler, 1981, Blood.

Marked Effect of the Combination of a Novel Vitamin D3 Analog, KH1060, and 9-cis-RA on Inhibition of Clonal Growth, Decreases of bcl-2 Level and Induction of Apoptosis in HL-60 Cells

H. Koeffler, L. Binderup, J. Said, 1997 .

Characterization of cDNA clones for human myeloperoxidase: predicted amino acid sequence and evidence for multiple mRNA species.

A. Carè, M. Selsted, H. Koeffler, 1987, Nucleic acids research.

Production of bone resorbing activity in poorly differentiated monocytic malignancy

H. Koeffler, D. Golde, G. Mundy, 1978, Cancer.

Protein partners of C/EBPε

M. Gross, A. Chumakov, H. Koeffler, 2004 .

Nuclear delivery of p53 C-terminal peptides into cancer cells using scFv fragments of a monoclonal antibody that penetrates living cells.

Carl W. Miller, H. Koeffler, K. Ferreri, 2003, Cancer letters.

Humoral modulation of human acute myelogenous leukemia cell growth in vitro.

H. Koeffler, P. Koeffler, D. Golde, 1980, Cancer research.

Comparative analysis of hypermethylation of cell cycle control and DNA-mismatch repair genes in low-density and CD34+ bone marrow cells from patients with myelodysplastic syndrome.

E. Thiel, H. Koeffler, S. Takeuchi, 2006, Leukemia research.

Differentiation therapy for myelodysplastic syndrome.

W. Hofmann, H. Koeffler, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Methylation Analysis of Cell Cycle Control Genes in Adult T-Cell Leukemia/Lymphoma

W. Hofmann, H. Koeffler, K. Tsukasaki, 2001, Leukemia & lymphoma.

Molecular analysis of the cyclin-dependent kinase inhibitor genes, p15, p16, p18 and p19 in the myelodysplastic syndromes.

C. Bartram, H. Koeffler, C. Miller, 1997, Leukemia research.

Differential Effects on Leukemic Cell Growth, Differentiation, and Intestinal Calcium Absorption1

H. Koeffler, M. Uskoković, A. Norman, 1990 .

Cloning of the Novel Human Myeloid-Cell-Speciﬁc C/EBP- e Transcription Factor

A. Chumakov, H. Koeffler, J. Slater, 1997 .

Molecular analysis of myeloperoxidase deficiency shows heterogeneous patterns of the complete deficiency state manifested at the genomic, mRNA, and protein levels

M. Selsted, H. Koeffler, M. Novotny, 1993 .

Molecular analysis of myeloperoxidase deficiency shows heterogeneous patterns of the complete deficiency state manifested at the genomic, mRNA, and protein levels.

M. Selsted, H. Koeffler, C. Miller, 1993, Blood.

Evidence for a pretranslational defect in hereditary and acquired myeloperoxidase deficiency.

M. Selsted, A. Tobler, H. Koeffler, 1989, Blood.

Herpesvirus 8 inclusions in primary effusion lymphoma: report of a unique case with T-cell phenotype.

E. Cesarman, H. Koeffler, S. Devos, 1999, Archives of pathology & laboratory medicine.

Loss of genomic imprinting of insulin-like growth factor 2 is strongly associated with cellular proliferation in normal hematopoietic cells.

W. Hofmann, H. Koeffler, S. Takeuchi, 2002, Experimental hematology.

Longitudinal inhibition of PI3K/Akt/mTOR signaling by LY294002 and rapamycin induces growth arrest of adult T-cell leukemia cells.

H. Koeffler, Yang Yang, T. Ikezoe, 2007, Leukemia research.

Potent vitamin D3 analogs: their abilities to enhance transactivation and to bind to the vitamin D3 response element.

H. Koeffler, J. Pike, Y. Imai, 1995, Leukemia research.

1,25(OH)2-16ene-vitamin D3 is a potent antileukemic agent with low potential to cause hypercalcemia.

S. de Vos, H. Koeffler, Y. Y. Lee, 1994, Leukemia research.

19-nor vitamin-D analogs: a new class of potent inhibitors of proliferation and inducers of differentiation of human myeloid leukemia cell lines.

N. Kamada, H. Koeffler, M. Uskoković, 1998, Blood.

Vitamin-D Analogs : A New Class of Potent Inhibitors of Proliferation and Inducers of Differentiation of Human Myeloid Leukemia Cell Lines

N. Kamada, H. Koeffler, M. Uskoković, 1998 .

Evidence for 1,25-dihydroxyvitamin D3 production by cultured porcine alveolar macrophages

H. Koeffler, A. Norman, H. Reichel, 1991, Molecular and Cellular Endocrinology.

Molecular allelokaryotyping of T-cell prolymphocytic leukemia cells with high density single nucleotide polymorphism arrays identifies novel common genomic lesions and acquired uniparental disomy

M. Dyer, S. Ogawa, M. Stern, 2009, Haematologica.

CEBPD suppresses prolactin expression and prolactinoma cell proliferation.

S. Melmed, H. Koeffler, A. Gutierrez-Hartmann, 2011, Molecular endocrinology.

Structural and Functional Studies of CCAAT/Enhancer-binding Protein ε*

H. Koeffler, Jianguo Tang, 2001, The Journal of Biological Chemistry.

Mutational Spectrum Analysis of Interesting Correlation and Interrelationship Between RNA Splicing Pathway and Commonly Targeted Genes in Myelodysplastic Syndrome

S. Miyano, Y. Shiraishi, S. Ogawa, 2011 .

Recurrent Mutations of Multiple Components of Cohesin Complex in Myeloid Neoplasms

S. Ishikawa, H. Aburatani, K. Shirahige, 2012 .

Title Single nucleotide polymorphism genomic arrays analysis of t ( 8 ; 21 ) acutemyeloid leukemia cells

J. Gerss, S. Ogawa, A. Nordgren, 2017 .

Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells

J. Gerss, S. Ogawa, A. Nordgren, 2009, Haematologica.

Lymphocyte cell lines from vitamin D-dependent rickets type II show functional defects in the 1α,25-dihydroxyvitamin D3 receptor

A. Tobler, H. Koeffler, A. Norman, 1990, Molecular and Cellular Endocrinology.

Myelodysplastic syndromes.

H. Koeffler, 1996, Seminars in hematology.

Splenic Irradiation in Myelofibrosis: Effect on Circulating Myeloid Progenitor Cells

H. Koeffler, D. Golde, M. Cline, 1979, British journal of haematology.

Chronic myelocytic leukemia: eosinophils involved in the malignant clone.

A. Levine, H. Koeffler, R. Sparkes, 1980, Blood.

1 alpha,25-Dihydroxy-20-epi-vitamin D3: an extraordinarily potent inhibitor of leukemic cell growth in vitro.

H. Koeffler, Y. Y. Lee, L. Binderup, 1994, Blood.

p16 (CDKN2/cyclin-dependent kinase-4 inhibitor/multiple tumor suppressor-1) gene is not altered in uterine cervical carcinomas or cell lines.

H. Koeffler, C. Miller, S. Wilczynski, 1996, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

The ATM gene and susceptibility to childhood T‐cell acute lymphoblastic leukaemia

C. Bartram, H. Koeffler, H. Taguchi, 1998, British journal of haematology.

H. Koeffler, B. Rosenbloom, R. Schreck, 1992, Hematology/oncology clinics of North America.

Analysis of c-kit gene integrity in aplastic anemia.

H. Koeffler, R. Paquette, N. C. Hsu, 1996, Blood cells, molecules & diseases.

Expression of Id2 and Id3 mRNA in human lymphocytes.

A. Tobler, H. Koeffler, K. Spirin, 1995, Leukemia research.

Comparative analysis of genes regulated by PML/RAR (cid:1) and PLZF/RAR (cid:1) in response to retinoic acid using oligonucleotide arrays

H. Koeffler, Dorothy J. Park, P. T. Vuong, 2003 .

Expression and regulation of G1 cell-cycle inhibitors (p16INK4A , p15INK4B, p18 INK4C, p19INK4D ) in human acute myeloid leukemia and normal myeloid cells

M. Fey, A. Tobler, H. Koeffler, 1997, Leukemia.

Human acute myeloid leukemia lines: models of leukemogenesis.

H. Koeffler, 1986, Seminars in hematology.

CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50.

Huaitian Liu, J. Kowalski, L. Boxer, 2005, Molecular cancer research : MCR.

c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression.

H. Koeffler, S. Diederichs, G. Idos, 1999, Blood.

HumoralModulationof Human Acute MyelogenousLeukemia Cell Growth in

H. Koeffler, D. Golde, 1980 .

Responsiveness of a human myelogenous leukemia cell line (KG-1) to humoral factors in vivo.

H. Koeffler, D. Golde, M. Cline, 1980, Leukemia research.

Cellular maturation in human preleukemia.

H. Koeffler, D. Golde, 1978, Blood.

Inhibition of MEK/ERK signaling synergistically potentiates histone deacetylase inhibitor-induced growth arrest, apoptosis and acetylation of histone H3 on p21waf1 promoter in acute myelogenous leukemia cell

H. Koeffler, T. Ikezoe, C. Nishioka, 2008, Leukemia.

Resveratrol, a Natural Product Derived from Grapes, Is a New Inducer of Differentiation in Human Myeloid Leukemias

T. Kyo, N. Kamada, H. Koeffler, 2002, International journal of hematology.

The aberrant fusion proteins PML-RARα and PLZF-RARα contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia

H. Koeffler, W. Berdel, H. Serve, 2000 .

C/EBPε ΔRS derived from a neutrophil-specific granule deficiency patient interacts with HDAC1 and its dysfunction is restored by trichostatin A.

T. Yokota, H. Koeffler, T. Akagi, 2019, Biochemical and biophysical research communications.

Infrequent alterations of the RAR alpha gene in acute myelogenous leukemias, retinoic acid-resistant acute promyelocytic leukemias, myelodysplastic syndromes, and cell lines.

P. Pelicci, C. Bartram, H. Koeffler, 1996, Blood.

Methylation of the Cyclin A1 Promoter Correlates with Gene Silencing in Somatic Cell Lines, while Tissue-Specific Expression of Cyclin A1 Is Methylation Independent

C. Readhead, H. Koeffler, S. Diederichs, 2000, Molecular and Cellular Biology.

Increased expression of p53 protein in human leukemia cells.

H. Koeffler, M. Nicolson, R. Bosselman, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Expression of retinoic acid receptor-beta sensitizes prostate cancer cells to growth inhibition mediated by combinations of retinoids and a 19-nor hexafluoride vitamin D3 analog.

H. Koeffler, M. Dawson, M. Uskoković, 1998, Endocrinology.

Establishment of a novel human B‐cell line (OZ) with t(14;18)(q32;q21) and aberrant p53 expression was associated with the homozygous deletions of p15INK4B and p16INK4A genes

M. Taniwaki, H. Koeffler, J. Takahara, 1997, Hematological oncology.

Double minute chromosomes containing MYB gene and NUP214-ABL1 fusion gene in T-cell leukemia detected by single nucleotide polymorphism DNA microarray and fluorescence in situ hybridization.

S. Ogawa, H. Koeffler, N. Kawamata, 2009, Leukemia research.

Combination of a potent 20-epi-vitamin D3 analogue (KH 1060) with 9-cis-retinoic acid irreversibly inhibits clonal growth, decreases bcl-2 expression, and induces apoptosis in HL-60 leukemic cells.

John Calvin Reed, S. Krajewski, H. Koeffler, 1996, Cancer research.

Alterations of the p16 (MTS1) gene in testicular, ovarian, and endometrial malignancies.

S. Melmed, H. Koeffler, T. Strohmeyer, 1995, The Journal of urology.

Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk

James Allan, E. Papaemmanuil, J. Vijayakrishnan, 2010, Nature Genetics.

Chronic Myelocytic Leukaemia: a Pluripotent Haemopoietic Cell is Involved in the Malignant Clone

H. Koeffler, D. Douer, R. Sparkes, 1981, British journal of haematology.

TEL is one of the targets for deletion on 12p in many cases of childhood B-lineage acute lymphoblastic leukemia

D. Gilliland, H. Koeffler, A. Reiter, 1997, Leukemia.

BCL6 enables Ph+ acute lymphoblastic leukemia cells to survive BCR-ABL1 kinase inhibition

Sebastian Herzog, Hong Wu, Eugene Park, 2011, Nature.

Cyclin A1 expression in leukemia and normal hematopoietic cells.

M. Lübbert, H. Koeffler, T. Nakamaki, 1999, Blood.

Vitamin D and Hematologic Malignancies

H. Koeffler, R. Okamoto, T. Akagi, 2011 .

Chapter 88 – Hematological Malignancy

H. Koeffler, R. Okamoto, Ryoko Okamoto, 2011 .

CHAPTER 27 – Differentiation Induction in Leukemia and Lymphoma

S. de Vos, H. Koeffler, S. Vos, 2006 .

Vitamin D3 and Retinoid-Mediated Inhibition of Leukemic Cells

H. Koeffler, M. Campbell, 1998 .

Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications

H. Koeffler, 1983 .

Induction of apoptosis by vitamin D3 analogue EB1089 in NCI‐H929 myeloma cells via activation of caspase 3 and p38 MAP kinase

H. Koeffler, Y. Y. Lee, Young Y. Lee, 2000, British journal of haematology.

A ligand of peroxisome proliferator-activated receptor gamma, retinoids, and prevention of preneoplastic mammary lesions.

E. Williamson, H. Koeffler, R. Mehta, 2000, Journal of the National Cancer Institute.

Effects of novel retinoid X receptor-selective ligands on myeloid leukemia differentiation and proliferation in vitro.

M. Pfahl, D. Heber, H. Koeffler, 1996, Blood.

Effects of harringtonine in combination with acivicin, adriamycin, L-asparaginase, cytosine arabinoside, dexamethasone, fluorouracil or methotrexate on human acute myelogenous leukemia cell line KG-1

H. Koeffler, J. Holland, T. Ohnuma, 2004, Investigational New Drugs.

Amygdalin (Laetrile): effect on clonogenic cells from human myeloid leukemia cell lines and normal human marrow.

H. Koeffler, D. Golde, L. Lowe, 1980, Cancer treatment reports.

JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA)

H. Koeffler, Y. Yang, H. Taguchi, 2004, British Journal of Cancer.

5-fluorocytosine: inhibition of hematopoiesis in vitro and reversal of inhibition by uracil.

H. Koeffler, D. Golde, David W. Golde, 1979, The Journal of infectious diseases.

Amphotericin inhibition of hematopoiesis in vitro

H. Koeffler, D. Golde, 1977, American journal of hematology.

TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia.

H P Koeffler, T. Golub, D. Neuberg, 1996, Blood.

Ganoderma lucidum causes apoptosis in leukemia, lymphoma and multiple myeloma cells.

N. Seeram, D. Heber, H. Koeffler, 2006, Leukemia research.

Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines.

D. Heber, H. Koeffler, T. Kumagai, 2007, Leukemia research.

RWJ-241947 (MCC-555), A Unique Peroxisome Proliferator-Activated Receptor-γ Ligand with Antitumor Activity against Human Prostate Cancer in Vitro and in Beige/Nude/ X-Linked Immunodeficient Mice and Enhancement of Apoptosis in Myeloma Cells Induced by Arsenic Trioxide

H. Koeffler, T. Ikezoe, J. Said, 2004, Clinical Cancer Research.

Novel therapeutic approach: organic arsenical (melarsoprol) alone or with all-trans -retinoic acid markedly inhibit growth of human breast and prostate cancer cells in vitro and in vivo

E. Williamson, H. Koeffler, J. Said, 2000, British Journal of Cancer.

Germline mutation of the p27/Kip1 gene in childhood acute lymphoblastic leukemia

H. Koeffler, T. Ikezoe, H. Taguchi, 2002, Leukemia.

Kaposi's sarcoma‐associated herpesvirus/human herpesvirus type 8 encephalitis in HIV‐positive and ‐negative individuals

S. de Vos, H. Koeffler, J. Said, 1997, AIDS.

Multiple myeloma presenting as ascites.

H. Koeffler, M. Cline, 1977, The Western journal of medicine.

An undifferentiated variant derived from the human acute myelogenous leukemia cell line (KG-1).

H. Koeffler, D. Golde, R. Sparkes, 1980, Blood.

Regulation of gene expression of myeloperoxidase during myeloid differentiation

Carl W. Miller, Andreas Tobler, M. Selsted, 1988, Journal of cellular physiology.

Peroxisome proliferator-activated receptor γ and cancers

H. Koeffler, 2003 .

Differential effects of various protein kinase C activators on protein phosphorylation in human acute myeloblastic leukemia cell line KG-1 and its phorbol ester-resistant subline KG-1a.

H. Koeffler, Z. Kiss, M. Shoji, 1987, Cancer research.

Modulation by retinoids and interferons of alkaline phosphatase activity in granulocytes induced by granulocyte colony-stimulating factor.

S. Asano, H. Koeffler, F. Takaku, 1989, Experimental Hematology.

Human preleukemia.

Koeffler, H. Koeffler, D. Golde, 1980, Annals of internal medicine.

Molecular mechanisms of cancer.

C. Denny, F. McCormick, H. Koeffler, 1991, The Western journal of medicine.

Recombinant human TNF induces production of granulocyte–monocyte colony-stimulating factor

H. Koeffler, J. Gasson, M. Ogawa, 1986, Nature.

Identification of neutrophil alkaline phosphatase‐inducing factor in cystic fluid of a human squamous cell carcinoma as granulocyte colony‐stimulating factor

H. Koeffler, O. Takatani, N. Sato, 1988, Journal of cellular physiology.

Is immunoreactivity for p53 useful in distinguishing benign from malignant effusions? Localization of p53 gene product in benign mesothelial and adenocarcinoma cells.

H. Koeffler, J. Said, A. Walts, 1994, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

Myeloid cell lines: tools for studying differentiation of normal and abnormal hematopoietic cells.

M. Lübbert, H. Koeffler, 1988, Blood reviews.

Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications.

H P Koeffler, H. Koeffler, 1983, Blood.

Cellular Internalization of Insulin-like Growth Factor Binding Protein-3

P. Cohen, H. Koeffler, L. Ma, 2004, Journal of Biological Chemistry.

Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias.

Carl W. Miller, W. Hofmann, H. Koeffler, 2002, Blood.

Infrequent Alterations of the RARa Gene in Acute Myelogenous Leukemias , Retinoic Acid-Resistant Acute Promyelocytic Leukemias , Myelodysplastic Syndromes , and Cell Lines

Carl W. Miller, P. Pelicci, C. Bartram, 2002 .

A novel retinoic acid receptor (RAR)-selective antagonist inhibits differentiation and apoptosis of HL-60 cells: implications of RARalpha-mediated signals in myeloid leukemic cells.

H. Koeffler, M. Kizaki, K. Yamato, 1998, Leukemia research.

Effects of novel retinoic acid compound, 9-cis-retinoic acid, on proliferation, differentiation, and expression of retinoic acid receptor-alpha and retinoid X receptor-alpha RNA by HL-60 cells.

H. Koeffler, M. Kizaki, Y. Ikeda, 1993, Blood.

Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells.

P. Ikonomi, H. Koeffler, T. Nakamaki, 2001, Blood.

In Vivo Deficiency of Both C/EBPβ and C/EBPε Results in Highly Defective Myeloid Differentiation and Lack of Cytokine Response

D. Nowak, H. Koeffler, R. Okamoto, 2010, PloS one.

Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes.

H. Koeffler, S. Gery, Dorothy J. Park, 2004, Blood.

Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBPε and PU.1

Bruce E. Torbett, B. Torbett, H. Koeffler, 2003 .

Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice.

H. Koeffler, Dorothy J. Park, P. T. Vuong, 2002, Blood.

Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT/enhancer binding protein--epsilon.

H P Koeffler, A Komiyama, H. Koeffler, 2001, Blood.

9-cis-retinoic acid: effects on normal and leukemic hematopoiesis in vitro.

H. Koeffler, M. Kizaki, N. Tsuruoka, 1993, Blood.

Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro.

H P Koeffler, A Komiyama, H. Koeffler, 1999, Blood.

9-cis-retinoic acid : effects on normal and leukemic hematopoiesis in vitro

H. Koeffler, M. Kizaki, N. Tsuruoka, 1993 .

The specific N-ras mutation in rat 7,12-dimethylbenz[a]anthracene (DMBA)-induced leukemia.

H. Koeffler, S. Collins, T. Umiel, 1997 .

Polycythemia: mechanisms and management.

J. Adamson, H. Koeffler, D. Golde, 1981, Annals of internal medicine.

Vitamin D compounds: activity against microbes and cancer.

H. Koeffler, A. Gombart, Q. Luong, 2006, Anticancer research.

A Role for the PPARγ in Cancer Therapy

M. Campbell, C. Carlberg, H. Koeffler, 2008, PPAR research.

Ovarian Carcinomas: CCN Genes Are Aberrantly Expressed and CCN1 Promotes Proliferation of these Cells

Dong Xie, Carl W. Miller, Carl Miller, 2005, Clinical Cancer Research.

Blockade of MEK signaling potentiates 5‐Aza‐2′‐deoxycytidine‐induced apoptosis and upregulation of p21waf1 in acute myelogenous leukemia cells

H. Koeffler, N. Komatsu, T. Ikezoe, 2009, International journal of cancer.

SRSF2 mutations in 275 cases with chronic myelomonocytic leukemia (CMML).

S. Ogawa, A. Kohlmann, T. Haferlach, 2012, Blood.

Chromosomal abnormalities and novel disease‐related regions in progression from Barrett's esophagus to esophageal adenocarcinoma

Carl W. Miller, S. Ogawa, S. Meltzer, 2009, International journal of cancer.

Cloning of genes involved in chromosomal translocations by high-resolution single nucleotide polymorphism genomic microarray

Martin Zimmermann, Carl W. Miller, Rolf Koehler, 2008, Proceedings of the National Academy of Sciences.

p53 in chronic myelogenous leukemia. Study of mechanisms of differential expression

M. Lübbert, H. Koeffler, C. Miller, 1988, The Journal of experimental medicine.

Poly(ADP‐ribosyl)ation of BRD7 by PARP1 confers resistance to DNA‐damaging chemotherapeutic agents

E. Song, Shuangbing Xu, K. Hu, 2019, EMBO reports.

Mechanisms of growth control of Kaposi's sarcoma-associated herpes virus-associated primary effusion lymphoma cells.

N. Kamada, H. Koeffler, D. Park, 1998, Blood.

Role of tumor suppressor genes in the development of adult T cell leukemia/lymphoma (ATLL)

H. Koeffler, Y. Hatta, 2002, Leukemia.

p21WAF1 mutations and human malignancies.

H. Koeffler, K. Koike, A. Komiyama, 1997, Leukemia & lymphoma.

Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1,25‐dihydroxyvitamin D3

H. Koeffler, A. Gombart, N. Borregaard, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells.

H. Koeffler, T. Ikezoe, Jing Yang, 2008, Leukemia research.

Ki11502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo.

H. Koeffler, T. Ikezoe, Jing Yang, 2008, Blood.

The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: enhancement of growth inhibition via inhibition of mammalian target of rapamycin signaling

H. Koeffler, N. Komatsu, Yang Yang, 2006, Molecular Cancer Therapeutics.

Genome-Wide Mapping Of Copy Number Variations using SNP Arrays

D. Nowak, W. Hofmann, H. Koeffler, 2009, Transfusion Medicine and Hemotherapy.

Peroxisome Proliferator-activated Receptor and Cancers 1

H. Koeffler, 2003 .

Detailed deletion mapping of the long arm of chromosome 6 in adult T-cell leukemia.

M. Tomonaga, H. Koeffler, Yasuaki Yamada, 1999, Blood.

Metabolic gatekeeper function of B-lymphoid transcription factors

T. Graeber, R. Dickins, K. Yamamoto, 2016, Nature.

Nonsteroidal anti-inflammatory drugs suppress glioma via 15-hydroxyprostaglandin dehydrogenase.

K. Black, H. Tai, H. Koeffler, 2008, Cancer research.

C/EBP-ε: Chromosomal mapping and mutational analysis of the gene in leukemia and preleukemia

A. Chumakov, H. Koeffler, N. Tsuruoka, 1997 .

Comparative genomic hybridization in childhood acute lymphoblastic leukemia: correlation with interphase cytogenetics and loss of heterozygosity analysis.

A. Jauch, B. Schoell, A. Teigler‐Schlegel, 2001, Cancer genetics and cytogenetics.

Differentiation therapy of leukemia: 3 decades of development.

Daniel Nowak, H Phillip Koeffler, D. Nowak, 2009, Blood.

Novel Therapeutic Approach: Ligands for PPARγ and Retinoid Receptors Induce Apoptosis in bcl-2-positive Human Breast Cancer Cells

D. Heber, E. Williamson, H. Koeffler, 2002, Breast Cancer Research and Treatment.

Ligand for peroxisome proliferator-activated receptor gamma (troglitazone) has potent antitumor effect against human prostate cancer both in vitro and in vivo.

H P Koeffler, E. Williamson, H. Koeffler, 1998, Cancer research.

CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia.

D. Tenen, H. Koeffler, D. Perrotti, 2003, Blood.

Presence of the BCR-ABL mutation Glu255Lys prior to STI571 (imatinib) treatment in patients with Ph+ acute lymphoblastic leukemia.

W. Hofmann, H. Koeffler, H. Gschaidmeier, 2003, Blood.

Methylation of the p16INK4A gene in multiple myeloma

H. Koeffler, J. Takahara, J. Said, 1998, British journal of haematology.

Extensive analysis of the retinoblastoma gene in adult T cell leukemia/lymphoma (ATL)

M. Tomonaga, H. Koeffler, Yasuaki Yamada, 1997, Leukemia.

Frequency and structure of p53 rearrangements in human osteosarcoma.

D. Slamon, H. Koeffler, C. Miller, 1990, Cancer research.

Translocation Products in Acute Myeloid Leukemia Activate the Wnt Signaling Pathway in Hematopoietic Cells

Ping Ji, Hubert Serve, Sven Diederichs, 2004, Molecular and Cellular Biology.

ATM‐Dependent Recruitment of BRD7 is required for Transcriptional Repression and DNA Repair at DNA Breaks Flanking Transcriptional Active Regions

E. Song, Yue-Xin Cai, K. Hu, 2020, Advanced science.

Characterization of a Myeloid Tyrosine Phosphatase, Lyp, and Its Role in the Bcr-Abl Signal Transduction Pathway*

L. Shih, E. Williamson, H. Koeffler, 2003, Journal of Biological Chemistry.

Molecular allelokaryotyping of relapsed pediatric acute lymphoblastic leukemia.

S. Ogawa, J. Harbott, M. Schrappe, 2009, International journal of oncology.

Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray.

Carl W. Miller, S. Ogawa, K. Hemminki, 2007, Blood.

Allelotype analysis of adult T-cell leukemia.

M. Tomonaga, H. Koeffler, J. Said, 1998, Blood.

Molecular analysis of the INK4 family of genes in prostate carcinomas.

H. Koeffler, D. Park, C. Miller, 1997, The Journal of urology.

Homozygous Deletion of the p16 Gene in Childhood Acute Lymphoblastic Leukemia

Carl W. Miller, C. Bartram, A. Tobler, 1997 .

Alterations of CDKN2 (p16) in non‐small cell lung cancer

Carl W. Miller, H. Koeffler, A. Gombart, 1995, Genes, chromosomes & cancer.

Absence of WAF1 mutations in a variety of human malignancies.

B. Vogelstein, W. El-Deiry, H. Koeffler, 1994, Blood.

Ordering of mutations in acute myeloid leukemia with partial tandem duplication of MLL (MLL-PTD)

S Miyano, T Haferlach, H P Koeffler, 2016, Leukemia.

chromosome 12p12.3-13.1 (region of TEL and Kip1 loci) and chromosome 12q23-ter: evidence for two new genes.

J. Yokota, H. Koeffler, S. Takeuchi, 2007 .

Advances in Brief Mutational Effects on the pl 6 INK 4 a Tumor Suppressor Protein 1

H. Koeffler, Manuel, Adrián, 2006 .

Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines.

H P Koeffler, H. Koeffler, R. Morosetti, 1997, Cancer research.

Ovarian cancer has frequent loss of heterozygosity at chromosome 12p12.3-13.1 (region of TEL and Kip1 loci) and chromosome 12q23-ter: evidence for two new tumour-suppressor genes.

J. Yokota, H. Koeffler, Y. Hatta, 1997, British Journal of Cancer.

Mutational analysis of the candidate tumor suppressor genes TEL and KIP1 in childhood acute lymphoblastic leukemia.

S. Bohlander, K. Stegmaier, H. Koeffler, 1996, Cancer research.

Mutations of the CHK2 gene are found in some osteosarcomas, but are rare in breast, lung, and ovarian tumors

Carl W. Miller, W. Hofmann, H. Koeffler, 2002, Genes, chromosomes & cancer.

Methylation analysis of the cell cycle control genes in myelofibrosis with myeloid metaplasia.

H. Koeffler, A. Tefferi, T. Kumagai, 2005, Leukemia research.

Loss of p73 gene expression in leukemias/lymphomas due to hypermethylation.

C. Bartram, Y. Matsuo, H. Koeffler, 1999, Blood.

NEOPLASIA Loss of p 73 Gene Expression in Leukemias / Lymphomas Due to Hypermethylation

Carl W. Miller, C. Bartram, Y. Matsuo, 1999 .

Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study

David Elashoff, H Phillip Koeffler, S. de Vos, 2002, The Lancet.

Myelodysplastic Syndromes: Molecular mechanisms and gene expression patterns in myelodysplastic syndromes

W. Hofmann, H. Koeffler, 2005 .

Differentiation inducers and their potential use in the treatment of acute myelogenous leukaemia

A. Tobler, H. Koeffler, 1992 .

Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype

Carl W. Miller, S. Ogawa, T. Haferlach, 2009, Haematologica.

Genome-Wide Loss of Heterozygosity and Uniparental Disomy in BRCA1/2-Associated Ovarian Carcinomas

Carl W. Miller, B. Karlan, S. Ogawa, 2008, Clinical Cancer Research.

Analysis of mutations of neurofibromatosis type 1 gene and N‐ras gene in acute myelogenous leukemia

Y. Bang, H. Koeffler, B. Kim, 1995, Stem cells.

Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein a in myelodysplastic syndromes and acute myeloid leukemias

Carl W. Miller, W. Hofmann, H. Koeffler, 2002 .

Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor.

F. Ginhoux, N. Salomonis, E. Newell, 2020, Immunity.

Hidden Abnormalities and Novel Classification of t(15;17) APL Based on Genomic Alterations.

Carl W. Miller, S. Ogawa, D. Liang, 2007 .

N-ras mutations are associated with poor prognosis and increased risk of leukemia in myelodysplastic syndrome.

F. McCormick, M. Lübbert, H. Koeffler, 1993, Blood.

Adaptor protein Lnk inhibits c‐Fms‐mediated macrophage function

D. Underhill, H. Koeffler, H. Goodridge, 2010, Journal of leukocyte biology.

Cyclin A1 directly interacts with B-myb and cyclin A1/cdk2 phosphorylate B-myb at functionally important serine and threonine residues: tissue-specific regulation of B-myb function.

C. Readhead, M. Saville, R. Watson, 2001, Blood.

Breast Cancer

Carl W. Miller, J. Gornbein, H. Koeffler, 2001, The Journal of Biological Chemistry.

Copy number analysis identifies tumor suppressive lncRNAs in human osteosarcoma.

Carl W. Miller, S. Ogawa, M. Sanada, 2017, International Journal of Oncology.

Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation.

S. de Vos, W. Hofmann, H. Koeffler, 2002, Blood.

Cell Cycle Alterations in the Blastoid Variant of Mantle Cell Lymphoma (MCL-BV) as Detected by Gene Expression Profiling of Mantle Cell Lymphoma (MCL) and MCL-BV

S. de Vos, S. Swerdlow, G. Pinkus, 2003, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

Induction of Immunity Against Leukemia

H. Koeffler, W. McBride, D. Kohn, 1996 .

High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.

J. Fagin, H. Koeffler, A. Karmakar, 1993, The Journal of clinical investigation.

Decreased expression of p33ING1 mRNA in lymphoid malignancies

H. Koeffler, J. Takahara, K. Riabowol, 1999, American journal of hematology.

Localization of the c-ets-2 transactivation domain

A M Chumakov, D L Chen, E A Chumakova, 1993, Journal of virology.

Glucocorticoid sensitivity and receptors in cells of human myelogenous leukemia lines.

H. Koeffler, M. Lippman, D. Golde, 1980, Cancer research.

myeloproliferative neoplasms negative - leukemic transformation of Philadelphia chromosome Prevalence and prognostic impact of allelic imbalances associated with

S. Ogawa, L. Shih, A. Nagler, 2011 .

Leukaemic Transformation of Philadelphia-chromosome-negative Myeloproliferative Neoplasms — A Review of the Molecular Background

H. Koeffler, N. Thoennissen, 2011 .

Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms.

D. Gilliland, S. Ogawa, T. Haferlach, 2009, Blood.

Gain-of-function c-CBL mutations associated with uniparental disomy of 11q in myeloid neoplasms

S. Ogawa, H. Nakauchi, M. Sanada, 2010, Cell cycle.

N-ras gene point mutations in childhood acute lymphocytic leukemia correlate with a poor prognosis.

F. McCormick, F. Herrmann, R. Mertelsmann, 1990, Blood.

BRCC3 mutations in myeloid neoplasms

H. Aburatani, S. Miyano, Y. Shiraishi, 2015, Haematologica.

Detection of Aberrant Gene Expression in CD34+ Hematopoietic Stem Cells from Patients with Agnogenic Myeloid Metaplasia Using Oligonucleotide Microarrays

W. Hofmann, H. Koeffler, A. Tefferi, 2005, Stem cells.

Mutational effects on the p16INK4a tumor suppressor protein.

H P Koeffler, M. Serrano, H. Koeffler, 1995, Cancer research.

Suberoylanilide hydroxamic acid (SAHA; vorinostat) suppresses translation of cyclin D1 in mantle cell lymphoma cells.

H. Koeffler, N. Kawamata, John Chen, 2007, Blood.

NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines

H. Koeffler, Y. Yang, T. Ikezoe, 2006, British Journal of Cancer.

Common deleted genes in the 5q− syndrome: thrombocytopenia and reduced erythroid colony formation in SPARC null mice

S. Lehmann, H. Koeffler, E. Sage, 2007, Leukemia.

PC-SPES down-regulates COX-2 via inhibition of NF-κB and C/EBPβ in non-small cell lung cancer cells

D. Heber, H. Koeffler, Yang Yang, 2006 .

Syndromes of acute nonlymphocytic leukemia.

H. Koeffler, 1987, Annals of internal medicine.

Cloning of the cyclin A1 Genomic Structure and Characterization of the Promoter Region

H. Koeffler, G. Idos, C. Müller, 1999, The Journal of Biological Chemistry.

Myelogenous Leukemia Lines Glucocorticoid Sensitivity and Receptors in Cells of Human

H. Koeffler, M. Lippman, D. Golde, 2013 .

Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

C Haferlach, H Aburatani, S Miyano, 2013, Leukemia.

Mutations of p53 in Wilms' tumors.

C. Bartram, H. Koeffler, S. Schneider, 1995, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARα/γ ligand TZD18

H. Koeffler, K. Possinger, Hongyu Liu, 2006 .

Growth inhibition and apoptosis in human Philadelphia chromosome-positive lymphoblastic leukemia cell lines by treatment with the dual PPARalpha/gamma ligand TZD18.

H. Koeffler, K. Possinger, Hongyu Liu, 2006, Blood.

Peroxisome proliferator-activated receptor gamma and retinoid X receptor ligands are potent inducers of differentiation and apoptosis in leukemias.

M. Konopleva, M. Andreeff, S. Kornblau, 2004, Molecular cancer therapeutics.

Association between a functional single nucleotide polymorphism in the MDM2 gene and sporadic endometrial cancer risk.

Carl W. Miller, B. Karlan, H. Koeffler, 2007, Gynecologic oncology.

Effect of a vitamin D3 analog, EB1089, on hematopoietic stem cells from normal and myeloid leukemic blasts.

H. Koeffler, D. Park, Y. Y. Lee, 1996, Leukemia.

Chronic phase of ETV6‐ABL1 positive CML responds to imatinib

S. Ogawa, H. Koeffler, N. Kawamata, 2008, Genes, chromosomes & cancer.

Functions of Cyclin A1 in the Cell Cycle and Its Interactions with Transcription Factor E2F-1 and the Rb Family of Proteins

H. Koeffler, A. Yee, C. Müller, 1999, Molecular and Cellular Biology.

20-Epi-vitamin D3 analogs. Potent modulators of proliferation and differentiation of breast cancer cell lines in vitro.

D. Heber, H. Koeffler, E. Elstner, 1996, Advances in experimental medicine and biology.

Downregulation of 14-3-3σ in ovary, prostate and endometrial carcinomas is associated with CpG island methylation

H. Hermeking, F. Herrmann, H. Koeffler, 2005, Modern Pathology.

CCAAT/Enhancer Binding Protein α (C/EBPα) and C/EBPα Myeloid Oncoproteins Induce Bcl-2 via Interaction of Their Basic Regions with Nuclear Factor-κB p50

Huaitian Liu, J. Kowalski, H. Koeffler, 2005, Molecular Cancer Research.

H. Koeffler, Dorothy J. Park, N. Thoennissen, 2013 .

Deficiency of myeloperoxidase and abnormal chromosome 1 occurs in variant (HL60) promyelocytes.

H. Koeffler, J. Peyman, T. Amatruda, 1986, Leukemia research.

1,25-Dihydroxyvitamin D3 induces differentiation of a retinoic acid-resistant acute promyelocytic leukemia cell line (UF-1) associated with expression of p21(WAF1/CIP1) and p27(KIP1).

H. Koeffler, M. Kizaki, K. Yamato, 1999, Blood.

Genetic differences between Asian and Caucasian chronic lymphocytic leukemia

S. Ogawa, A. Sato-Otsubo, H. Koeffler, 2013, International journal of oncology.

Down-Regulation of prostate-specific antigen expression by ligands for peroxisome proliferator-activated receptor gamma in human prostate cancer.

M. Carey, H. Koeffler, S. Tomoyasu, 2000, Cancer research.

Gene Expression Profile of Serial Samples of Transformed B-Cell Lymphomas

T. Grogan, T. Miller, W. Wachsman, 2003, Laboratory Investigation.

Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors

T. Graeber, R. Dickins, K. Yamamoto, 2018, Nature.

Altered apoptosis pathways in mantle cell lymphoma detected by oligonucleotide microarray.

S. de Vos, G. Pinkus, W. Wachsman, 2001, Blood.

Longitudinal inhibition of PI 3 K / Akt / mTOR signaling by LY 294002 and rapamycin induces growth arrest of adult T-cell leukemia cells

H. Koeffler, Yang Yang, T. Ikezoe, 2006 .

Comparative genomic hybridization analysis in adult T-cell leukemia/lymphoma: correlation with clinical course.

A. Jauch, C. Bartram, M. Tomonaga, 2001, Blood.

leukemia / lymphoma : correlation with clinical course Comparative genomic hybridization analysis in adult T-cell

A. Jauch, C. Bartram, M. Tomonaga, 2001 .

Discovery of epigenetically silenced genes in acute myeloid leukemias

T. Haferlach, W. Hofmann, H. Koeffler, 2007, Leukemia.

CCAAT/enhancer binding protein epsilon is a potential retinoid target gene in acute promyelocytic leukemia treatment.

W. Miller, A. Chumakov, H. Koeffler, 1999, The Journal of clinical investigation.

PHAGOCYTES Myeloid Transcription Factor C / EBP e Is Involved in the Positive Regulation of Lactoferrin Gene Expression in Neutrophils

H. Koeffler, Dorothy J. Park, P. T. Vuong, 1999 .

Effect of dasatinib against thyroid cancer cell lines in vitro and a xenograft model in vivo.

H P Koeffler, G. Braunstein, H. Koeffler, 2012, Oncology letters.

Preleukemia: one name, many meanings

H. Koeffler, G. Leong, Koeffler Hp, 2016, Leukemia.

Synergistic inhibition of prostate cancer cell lines by a 19- nor hexafluoride vitamin D3 analogue and anti-activator protein 1 retinoid

M. Campbell, H. Koeffler, M. Dawson, 1999, British Journal of Cancer.

Toward therapeutic intervention of cancer by vitamin D compounds.

M. Campbell, H. Koeffler, M. Campbell, 1997, Journal of the National Cancer Institute.

Regulation of the CAMP gene by 1,25(OH)2D3 in various tissues

H. Koeffler, A. Gombart, J. O'kelly, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

Myelodysplastic Bone Marrow Cells from Normal and + Characterization of Gene Expression of Cd34

H Phillip Koeffler, S. de Vos, W. Wachsman, 2002 .

Allelic loss in the progression of myelodysplastic syndrome.

M. Lübbert, H. Koeffler, H. Mizoguchi, 2000, Cancer research.

Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines.

H. Koeffler, N. Kawamata, S. Sakajiri, 2005, Experimental hematology.

Vitamin D(3) and its synthetic analogs inhibit the spontaneous in vitro immunoglobulin production by SLE-derived PBMC.

H. Koeffler, J. Klinenberg, J. Klinenberg, 2001, Clinical immunology.

Exaptation of an ancient Alu short interspersed element provides a highly conserved vitamin D-mediated innate immune response in humans and primates

H. Koeffler, A. Gombart, Tsuyako Saito, 2009, BMC Genomics.

Amiloride potentiation of differentiation of human promyelocytic cell line HL-60.

H. Koeffler, E. Cragoe, F. Dorey, 1984, Journal of the National Cancer Institute.

Action of granulocyte-macrophage colony-stimulating factors: studies using a human leukemia cell line.

H. Koeffler, A. J. Lusis, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Myeloid differentiation mediated through retinoic acid receptor/retinoic X receptor (RXR) not RXR/RXR pathway.

H. Koeffler, M. Kizaki, M. Dawson, 1994, Blood.

INHIBITION OF THE CLONAL GROWTH OF HUMAN MYELOID LEUKEMIA CELLS

H. Koeffler, D. Douer, 1982 .

Myeloperoxidase: Localization, Structure, and Function

A. Tobler, H. Koeffler, 1991 .

Progression of myelodysplastic syndrome: allelic loss on chromosomal arm 1p

H. Koeffler, H. Mizoguchi, R. Morosetti, 2003, British journal of haematology.

Oncogenes in multiple myeloma: point mutation of N-ras.

F. McCormick, H. Koeffler, R. Paquette, 1990, Oncogene.

Recombinant human TNF alpha stimulates production of granulocyte colony-stimulating factor.

H. Koeffler, J. Gasson, R. Munker, 1987, Blood.

Regional assignment of genes for human alpha-globin and phosphoglycollate phosphatase to the short arm of chromosome 16.

T. Mohandas, H. Koeffler, R. Sparkes, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Functional analysis of a novel DNA polymorphism of a tandem repeated sequence in the asparagine synthetase gene in acute lymphoblastic leukemia cells.

Carl W. Miller, H Phillip Koeffler, M. D. Den Boer, 2009, Leukemia research.

Randomized study of 13-cis retinoic acid v placebo in the myelodysplastic disorders.

D. Heitjan, R. Mertelsmann, J. Kolitz, 1988, Blood.

Molecular Biology of Thyroid Cancer

H. Koeffler, W. Chien, H. Koeffler, 2012 .

Cytokine messenger RNA stability is enhanced in tumor cells.

N. Sato, Y. Ueyama, H. Koeffler, 1991, Blood.

PC-SPES inhibits colon cancer growth in vitro and in vivo.

D. Heber, H. Koeffler, T. Ikezoe, 2002, Cancer research.

Transgenic mice overexpressing human copper/zinc-superoxide dismutase (Cu/Zn SOD) are not resistant to endotoxic shock.

S. de Vos, C. Epstein, H. Koeffler, 1995, Biochemical and biophysical research communications.

Analysis of the CHK2 Gene in Lymphoid Malignancies

Carl W. Miller, W. Hofmann, H. Koeffler, 2001, Leukemia & lymphoma.

Absence of HHV-8 in prostate and semen.

H. Koeffler, J. Said, T. Tasaka, 1996, The New England journal of medicine.

Characterization of adenosine‐uridine‐rich RNA binding factors

H. Koeffler, N. Tsuruoka, T. Nakamaki, 1995, Journal of cellular physiology.

Regulation of expression of murine transferrin receptor 2.

H. Koeffler, A. Gombart, X. Tong, 2001, Blood.

Transferrin Receptor 2-α Supports Cell Growth Both in Iron-chelated Cultured Cells and in Vivo *

Hiroshi Kawabata, H. Koeffler, T. Nakamaki, 2000, The Journal of Biological Chemistry.

Localization of Kaposi's sarcoma-associated herpesvirus in bone marrow biopsy samples from patients with multiple myeloma.

G. Pinkus, H. Koeffler, J. Said, 1997, Blood.

Herpesvirus 8 Inclusions in Primary Effusion Lymphoma

E. Cesarman, H. Koeffler, S. Devos, 2009 .

Transactivational and DNA binding abilities of endogenous p53 in p53 mutant cell lines.

A. Chumakov, H. Koeffler, D. Park, 1994, Oncogene.

Nanoelectropulse Intracellular Perturbation and Electropermeabilization Technology: Phospholipid Translocation, Calcium Bursts, Chromatin Rearrangement, Cardiomyocyte Activation, and Tumor Cell Sensitivity

L. Marcu, P.T. Vernier, Mya Mya Thu, 2005, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference.

Modulation of Mr 53,000 protein with induction of differentiation of human neuroblastoma cells.

H. Koeffler, N. Sidell, 1988, Cancer research.

Histone Deacetylase Inhibitors Have a Profound Antigrowth Activity in Endometrial Cancer Cells

H. Koeffler, J. Said, T. Kumagai, 2004, Clinical Cancer Research.

Altered Apoptosis Pathways in Mantle Cell Lymphoma

S. de Vos, W. Hofmann, H. Koeffler, 2004, Leukemia & lymphoma.

Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice.

H P Koeffler, D. Heber, E. Williamson, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Combination therapy of a vitamin D3 analog and all-trans-retinoic acid: effect on human breast cancer in nude mice.

H. Koeffler, M. Uskoković, L. Binderup, 1999, Anticancer research.

p53 mutations and MDM-2 amplification in renal cell cancers.

D. Slamon, H. Koeffler, T. Strohmeyer, 1994, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

DNA aneuploidy in morphologically normal colons from patients with colon cancer.

H. Koeffler, M. Fleischhacker, S. Takeuchi, 1995, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.

Mutations in the mitotic check point gene, MAD1L1, in human cancers

Carl W. Miller, C. Sawyers, M. Tomonaga, 2001, Oncogene.

Rare mutations of the PIK3CA gene in malignancies of the hematopoietic system as well as endometrium, ovary, prostate and osteosarcomas, and discovery of a PIK3CA pseudogene.

Carl W. Miller, H Phillip Koeffler, M. Gross, 2007, Leukemia research.

BRCA1 transactivates the cyclin-dependent kinase inhibitor p27Kip1

E. Williamson, H. Koeffler, F. Dadmanesh, 2002, Oncogene.

Chromatin and DNA Methylation Changes of the Human Myeloperoxidase Gene During Myeloid Differentiation

F. Herrmann, R. Mertelsmann, M. Lübbert, 1990 .

Expression of C/EBPbeta from the C/ebpalpha gene locus is sufficient for normal hematopoiesis in vivo.

W. Hofmann, H. Koeffler, Shih-Shun Chen, 2002, Blood.

Important features of myelodysplastic syndrome

W. Hofmann, H. Koeffler, 2002, International journal of hematology.

Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults

H. Koeffler, T. Nakamaki, Yohei Sasaki, 2021, International Journal of Hematology.

Differentiation-inducing agents in the treatment of myelodysplastic syndromes.

H. Koeffler, M. Kizaki, 1992, Seminars in oncology.

1α, 25-(OH)2-D3 and its synthetic analogue decrease tumor load in the Apcmin mouse

D. Heber, H. Koeffler, V. Go, 2002 .

Proteasome inhibitor PS‐341 down‐regulates prostate‐specific antigen (PSA) and induces growth arrest and apoptosis of androgen‐dependent human prostate cancer LNCaP cells

H. Koeffler, Yang Yang, T. Ikezoe, 2004, Cancer science.

Advances in the treatment of acute myeloid leukemia: From chromosomal aberrations to biologically targeted therapy

W. Hofmann, M. Lübbert, H. Koeffler, 2008, Journal of cellular biochemistry.

Deficiency of CCAAT/Enhancer Binding Protein-Epsilon Reduces Atherosclerotic Lesions in LDLR−/− Mice

A. Lusis, L. Castellani, H. Koeffler, 2014, PloS one.

Mutation analysis of the DNA-damage checkpoint gene CHK2 in myelodysplastic syndromes and acute myeloid leukemias.

W. Hofmann, H. Koeffler, C. Miller, 2001, Leukemia research.

H-Ferritin Is Preferentially Incorporated by Human Erythroid Cells through Transferrin Receptor 1 in a Threshold-Dependent Manner

N. Kadowaki, H. Koeffler, A. Takaori-Kondo, 2015, PloS one.

Study of differentiation of fresh myelogenous leukemic cells by compounds that induce a human promyelocytic leukemic line (HL-60) to differentiate.

H. Koeffler, K. Hirji, M. Prokocimer, 1985, Leukemia research.

Establishment of the acute myeloid leukemia cell line Kasumi‐6 from a patient with a dominant‐negative mutation in the DNA‐binding region of the C/EBPα gene

T. Inaba, H. Koeffler, A. Gombart, 2003, Genes, chromosomes & cancer.

TMEFF1 and brain tumors

D. Xie, K. Black, H. Koeffler, 2003, Oncogene.

D-factor: modulation of expression in fibroblasts.

H. Koeffler, M. Akashi, K. Yamato, 1991, Leukemia research.

Mutational analysis of the Hel-N1 gene in childhood acute lymphoblastic leukemia with LOH at 9p21

H. Koeffler, H. Taguchi, S. Takeuchi, 1999, Leukemia.

Cytostatic effect of TNFα on cancer cells is independent of p21WAF1

H. Koeffler, K. Koike, A. Komiyama, 1997, Oncogene.

An interferon-γ activation sequence mediates the transcriptional regulation of the IgG Fc receptor type IC gene by interferon-γ

H. Koeffler, R. Paquette, S. Nimer, 1995 .

Translocon‐associated protein α transcripts are induced by granulocyte‐macrophage colony‐stimulating factor and exhibit complex alternative polyadenylation

Carl W. Miller, H P Koeffler, H. Koeffler, 1999, FEBS letters.

p27/Kip1 mutation found in breast cancer.

H. Koeffler, C. Miller, K. Spirin, 1996, Cancer research.

ATF4 differentially regulates transcriptional activation of myeloid‐specific genes by C/EBPε and C/EBPα

H. Koeffler, A. Gombart, J. Grewal, 2007 .

Tumor necrosis factor stimulates Na+/H+ antiporter in human fibroblasts: dissociation between intracellular alkalinization and cytokine mRNA accumulation.

H. Koeffler, Y. Y. Lee, K. Yamato, 1992, Blood.

Growth inhibition and apoptosis in human Philadelphia chromosome – positive lymphoblastic leukemia cell lines by treatment with the dual PPAR / ligand TZD 18

H. Koeffler, K. Possinger, Hongyu Liu, 2006 .

Myeloperoxidase (MPO) gene mutation in hereditary MPO deficiency.

M. Selsted, H. Koeffler, C. Miller, 1994, Blood.

Rhabdomyolysis as a complication of 5-azacytidine.

H. Koeffler, C. Haskell, 1978, Cancer treatment reports.

Myelodysplastic syndromes (preleukemia).

H. Koeffler, 1986, Seminars in hematology.

Molecular analysis of the human myeloperoxidase promoter region.

A. Chumakov, H. Koeffler, D. Chih, 2000, International journal of oncology.

Mutations of the E2F4 gene in hematological malignancies having microsatellite instability.

C. Bartram, H. Koeffler, N. Komatsu, 2000, Blood.

Microsatellite instability in adult T‐cell leukaemia

M. Tomonaga, H. Koeffler, Yasuaki Yamada, 1998, British journal of haematology.

y-Interferon induces expression of the HLA-D antigens on normal and leukemic human myeloid cells ( major histocompatibility complex class II antigens )

H. Koeffler, J. Ranyard, R. Billing, 2022 .

The effect of retinoids on haemopoiesis--clinical and laboratory studies.

H. Koeffler, T. Amatruda, 1985, Ciba Foundation symposium.

Hematopoietic-specific expression of MEFV, the gene mutated in familial Mediterranean fever, and subcellular localization of its corresponding protein, pyrin.

H. Koeffler, A. Gombart, S. Kawano, 2000, Blood.

Vitamin D3 analogs and their 24‐Oxo metabolites equally inhibit clonal proliferation of a variety of cancer cells but have differing molecular effects

H P Koeffler, M. Campbell, H. Koeffler, 1997, Journal of cellular biochemistry.

Expression of retinoic acid receptor mRNA in hematopoietic cells.

H. Koeffler, C. Miller, M. Kizaki, 1990, Leukemia research.

Mutational analysis of the peroxisome proliferator-activated receptor gamma gene in human malignancies.

E. Williamson, H. Koeffler, C. Miller, 2001, Cancer research.

Growth inhibition of myeloid leukemia cells by troglitazone, a ligand for peroxisome proliferator activated receptor gamma, and retinoids.

N. Kamada, E. Williamson, H. Koeffler, 1999, International journal of oncology.

Vitamin D compounds in leukemia

H. Koeffler, Q. Luong, 2005, The Journal of Steroid Biochemistry and Molecular Biology.

Distinct and convergent consequences of splice factor mutations in myelodysplastic syndromes

M. Cazzola, S. Ogawa, T. Haferlach, 2020, American journal of hematology.

Use of conditioned media in cell culture can mask cytogenetic abnormalities in acute leukemia.

R. Gale, H. Koeffler, R. Sparkes, 1990, Cancer genetics and cytogenetics.

Frameshift mutations in caspase-5 and other target genes in leukemia and lymphoma cell lines having microsatellite instability.

H Phillip Koeffler, H. Koeffler, H. Taguchi, 2003, Leukemia research.

Mxi1 isoforms are expressed in hematological cell lines and normal bone marrow.

H. Koeffler, K. Oshimi, N. Kawamata, 2005, International journal of oncology.

T-antigen of sv40 blocks p53 transactivation but not p53 specific binding to DNA.

A. Chumakov, H. Koeffler, J. Said, 1994, International journal of oncology.

19-Nor-1,25(OH)2D2 (a novel, noncalcemic vitamin D analogue), combined with arsenic trioxide, has potent antitumor activity against myeloid leukemia.

L. Shih, H. Koeffler, J. O'kelly, 2005, Cancer research.

Mutations in the Retinoblastoma-related Gene RB2 / p130 in Adult T-cell Leukaemia/Lymphoma

H. Koeffler, K. Tsukasaki, S. Takeuchi, 2003, Leukemia & lymphoma.

The anti-proliferative effects of 1α,25(OH)2D3 on breast and prostate cancer cells are associated with induction of BRCA1 gene expression

H Phillip Koeffler, M. Campbell, H. Koeffler, 2000, Oncogene.

Chromosome band 1p36 contains a putative tumor suppressor gene important in the evolution of chronic myelocytic leukemia.

H. Koeffler, H. Mizoguchi, G. Schiller, 1998, Blood.

Expression of Retinoic Acid Receptor-β Sensitizes Prostate Cancer Cells to Growth Inhibition Mediated by Combinations of Retinoids and a 19-nor Hexafluoride Vitamin D3 Analog.

M. Campbell, H. Koeffler, M. Dawson, 1998, Endocrinology.

Cucurbitacin B induces differentiation, cell cycle arrest, and actin cytoskeletal alterations in myeloid leukemia cells.

T. Haritunians, H. Koeffler, D. Yin, 2008, Leukemia research.

Restoration of C/EBPα Expression in a BCR-ABL+ Cell Line Induces Terminal Granulocytic Differentiation*

H. Koeffler, S. Gery, Dorothy J. Park, 2003, Journal of Biological Chemistry.

Aberrant methylation in promoter-associated CpG islands of multiple genes in chronic myelogenous leukemia blast crisis.

H. Koeffler, Yang Yang, S. Takeuchi, 2012, Oncology letters.

Absence of microsatellite instability during the progression of chronic myelocytic leukemia

H. Koeffler, H. Mizoguchi, G. Schiller, 1997, Leukemia.

24-Oxo metabolites of vitamin D3 analogues: disassociation of their prominent antileukemic effects from their lack of calcium modulation.

H. Koeffler, M. Uskoković, J. Hisatake, 2001, Cancer research.

Myeloid Differentiation Mediated Through New Potent Retinoids and Vitamin D3 Analogs

H. Koeffler, M. Dawson, M. Uskoković, 1996 .

Infrequent microsatellite instability during the evolution of myelodysplastic syndrome to acute myelocytic leukemia.

H. Koeffler, J. Takahara, Y. Hatta, 1996, Leukemia research.

Genetic profiling of myeloproliferative disorders by single-nucleotide polymorphism oligonucleotide microarray.

Carl W. Miller, S. Ogawa, R. Levine, 2006, Experimental hematology.

Per2 Is a C/EBP Target Gene Implicated in Myeloid Leukemia

H. Koeffler, S. Gery, 2009, Integrative cancer therapies.

Histone deacetylase inhibitors induce growth arrest and apoptosis of HTLV-1-infected T-cells via blockade of signaling by nuclear factor kappaB.

H. Koeffler, N. Komatsu, T. Ikezoe, 2008, Leukemia research.

Arocalciferols: synthesis and biological evaluation of aromatic side-chain analogues of 1 alpha,25-dihydroxyvitamin D3(1a).

H. Koeffler, A. Norman, J. Zhou, 1991, Journal of medicinal chemistry.

Frequent loss of heterozygosity on the long arm of chromosome 6: identification of two distinct regions of deletion in childhood acute lymphoblastic leukemia.

M. Schrappe, H. Koeffler, A. Reiter, 1998, Cancer research.

Deletion in Childhood Acute Lymphoblastic Leukemia Chromosome 6 : Identification of Two Distinct Regions of Frequent Loss of Heterozygosity on the Long Arm of Updated

M. Schrappe, H. Koeffler, A. Reiter, 2006 .

The induction of apoptosis by a combined 1,25(OH)2D3 analog, EB1089 and TGF-beta1 in NCI-H929 multiple myeloma cells.

H. Koeffler, B. Kim, Young Y. Lee, 2002, International Journal of Oncology.

C/EBPε −/− mice: increased rate of myeloid proliferation and apoptosis

H. Koeffler, W. Verbeek, J Lekstrom-Himes, 2001, Leukemia.

Microsatellite instability and other molecular abnormalities in childhood acute lymphoblastic leukaemia

C. Bartram, H. Koeffler, J. Slater, 1997, British journal of haematology.

Expression of p‐JAK2 predicts clinical outcome and is a potential molecular target of acute myelogenous leukemia

M. Furihata, H. Koeffler, T. Ikezoe, 2011, International journal of cancer.

Mantle Cell Lymphoma: SAHA Blocks Akt/mTOR Pathway and Reduces Cyclin D1 Protein Levels by Affecting Translation.

H. Koeffler, N. Kawamata, 2004 .

Expression of CCN family members correlates with the clinical features of hepatocellular carcinoma.

H. Koeffler, D. Yin, D. Lin, 2015, Oncology Report.

The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARα and regulates differentiation of hematopoietic cells

H. Koeffler, L. Tickenbrock, W. Berdel, 2004, Oncogene.

Mutational analysis of the hMSH2 gene in a wide variety of tumors.

Y. Bang, M. Tomonaga, H. Koeffler, 1997, International Journal of Oncology.

Identification of a new GLC1A mutation in a sporadic, primary open-angle glaucoma in Japan.

H. Koeffler, N. Komatsu, T. Ikezoe, 2003, International journal of molecular medicine.

Methylenetetrahydrofolate reductase genotype does not play a role in adult T-cell leukemia/lymphoma pathogenesis among human T-lymphotrophic virus type 1 carriers.

Carl W. Miller, M. Tomonaga, H. Koeffler, 2004, Leukemia research.

Frequent loss of heterozygosity in the region of D1S450 at 1p36.2 in myelodysplastic syndromes.

D. Xie, W. Hofmann, H. Koeffler, 2001, Leukemia research.

Allelotype analysis of the myelodysplastic syndrome

D. Xie, H. Koeffler, D. Hoelzer, 2000, Leukemia.

Mutant p53 proteins have diverse intracellular abilities to oligomerize and activate transcription.

A. Chumakov, H. Koeffler, C. Miller, 1993, Oncogene.

1,25-Dihydroxyvitamin D3 receptor RNA: expression in hematopoietic cells

H. Koeffler, A. Karmakar, J. Bishop, 1991 .

Tumor Cell Differentiation: Biology and Pharmacology

P. Chiang, H. Koeffler, J. Aarbakke, 1987 .

Production of 1 alpha,25-dihydroxyvitamin D3 by hematopoietic cells.

H. Koeffler, A. Norman, H. Reichel, 1990, Progress in clinical and biological research.

Differentiation of human acute myelogenous leukemia cells: therapeutic possibilities.

A. Tobler, H. Koeffler, 1987, Acta haematologica.

Interaction of 1,25 Dihydroxyvitamin D3 with Normal and Abnormal Hematopoiesis

A. Tobler, H. Koeffler, A. Norman, 1987 .

Integrity of the 1,25‐dihydroxyvitamin D3 receptor in bone, lung, and other cancers

Carl W. Miller, M. Campbell, H. Koeffler, 1997, Molecular carcinogenesis.

Structure-function studies on analogues of 1 alpha,25-dihydroxyvitamin D3: differential effects on leukemic cell growth, differentiation, and intestinal calcium absorption.

H. Koeffler, M. Uskoković, A. Norman, 1990, Cancer research.

and Inducers of Differentiation of Human Breast Cancer Cell Lines

D. Heber, H. Koeffler, M. Uskoković, 1995 .

Effects of long-term administration of vitamin D3 analogs to mice.

S. Goldstein, H. Koeffler, M. Uskoković, 2000, The Journal of endocrinology.

Effects of long-term administration of vitamin D 3 analogs to mice

S. Goldstein, H. Koeffler, M. Uskoković, 2000 .

Intractable diarrhoea of infancy caused by neutrophil specific granule deficiency and cured by stem cell transplantation

H. Koeffler, A. Gombart, P. Arkwright, 2006, Gut.

The 16-Ene Vitamin D Analogs

H. Koeffler, M. Uskoković, G. P. Studzinski, 1997, Current Pharmaceutical Design.

Dominant Negative Form of PAX5 Is Generated by Multimerization of Its DNA Binding Domain

A. Berk, H. Koeffler, M. Pennella, 2010 .

The 16-Ene Vitamin D Analogues

H. Koeffler, M. Uskoković, G. P. Studzinski, 1997 .

Novel retinoic acid, 9-cis retinoic acid, in combination with all-trans retinoic acid is an effective inducer of differentiation of retinoic acid-resistant HL-60 cells.

H. Koeffler, M. Kizaki, Y. Ikeda, 1994, Blood.

Expression of the adaptor protein Lnk in leukemia cells.

W. Hofmann, H. Koeffler, S. Gery, 2009, Experimental hematology.

AntitumorActivity of Suberoylanilide Hydroxamic Acid against Thyroid Cancer Cell Lines In vitro and In vivo

G. Braunstein, H. Koeffler, J. O'kelly, 2006 .

The aberrant fusion proteins PML-RAR alpha and PLZF-RAR alpha contribute to the overexpression of cyclin A1 in acute promyelocytic leukemia.

H. Koeffler, D. Park, W. Berdel, 2000, Blood.

Molecular analysis of the cyclin-dependent kinase inhibitor gene p27/Kip1 in human malignancies.

C. Bartram, H. Koeffler, D. Park, 1995, Cancer research.

Microsatellite instability during the progression of acute myelocytic leukaemia

H. Koeffler, J. Takahara, S. Takeuchi, 1997, British journal of haematology.

Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia.

K. Coombes, Nianxiang Zhang, A. Melnick, 2015, Cancer cell.

Vitamin D3 analogs inhibit growth and induce differentiation in LA-N-5 human neuroblastoma cells

H. Koeffler, Randal K. Wada, J. Yamashiro, 1996, Clinical & Experimental Metastasis.

Effect of a novel vitamin D3 analog, EB1089, on G1 cell cycle regulatory proteins in HL-60 cells.

H. Koeffler, Y. Y. Lee, W. Park, 2000, International journal of oncology.

p21WAF1 expression by an activator of protein kinase C is regulated mainly at the post-transcriptional level in cells lacking p53: important role of RNA stabilization.

H. Koeffler, M. Akashi, M. Hachiya, 1999, The Biochemical journal.

Normal myelopoiesis but abnormal T lymphocyte responses in vitamin D receptor knockout mice.

H. Koeffler, J. Hisatake, A. Norman, 2002, The Journal of clinical investigation.

ATF4 differentially regulates transcriptional activation of myeloid-specific genes by C/EBPepsilon and C/EBPalpha.

H. Koeffler, A. Gombart, J. Grewal, 2007, Journal of Leukocyte Biology.

Comparative analysis of genes regulated by PML/RAR alpha and PLZF/RAR alpha in response to retinoic acid using oligonucleotide arrays.

H Phillip Koeffler, S. de Vos, H. Koeffler, 2003, Blood.

Stable methylation patterns of MYC and other genes regulated during terminal myeloid differentiation.

W. Salser, M. Lübbert, H. Koeffler, 1991, Leukemia.

Vitamin D Receptor Gene Polymorphisms and Prognosis of Breast Cancer among African-American and Hispanic Women

J. Vadgama, D. Heber, H. Koeffler, 2013, PloS one.

Successive increases in human cyclin A1 promoter activity during spermatogenesis in transgenic mice.

C. Readhead, H. Koeffler, S. Diederichs, 2003, International journal of molecular medicine.

Tumor necrosis factor alpha: posttranscriptional stabilization of WAF1 mRNA in p53-deficient human leukemic cells.

H. Koeffler, M. Akashi, A. Gombart, 1996, Journal of Cellular Physiology.

Discovery of over-expressed genes and genetic alterations in breast cancer cells using a combination of suppression subtractive hybridization, multiplex FISH and comparative genomic hybridization.

A. Jauch, D. Xie, C. Bartram, 2002, International journal of oncology.

ZD6474 induces growth arrest and apoptosis of human leukemia cells, which is enhanced by concomitant use of a novel MEK inhibitor, AZD6244

H. Koeffler, N. Komatsu, Y. Yang, 2007, Leukemia.

Protein partners of C/EBPepsilon.

M. Gross, A. Chumakov, H. Koeffler, 2004, Experimental hematology.

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells

M. Haussler, D. Mangelsdorf, H. Koeffler, 1984, The Journal of cell biology.

WAF 1 / CIP 1 Expression of p 21 Resistant Acute Promyelocytic Leukemia Cell Line ( UF-1 ) Associated With − Induces Differentiation of a Retinoic Acid 31 , 25-Dihydroxyvitamin D

H. Koeffler, M. Kizaki, K. Yamato, 1999 .

HEMATOPOIESIS 1 , 25-Dihydroxyvitamin D 3 Induces Differentiation of a Retinoic Acid – Resistant Acute Promyelocytic Leukemia

H. Koeffler, M. Kizaki, K. Yamato, 1999 .

CCAAT/Enhancer Binding Protein α (C/EBPα) and C/EBPα Myeloid Oncoproteins Induce Bcl-2 via Interaction of Their Basic Regions with Nuclear Factor-κB p50

Huaitian Liu, H. Koeffler, A. Blackford, 2005, Molecular Cancer Research.

Frequent genomic abnormalities in acute myeloid leukemia/myelodysplastic syndrome with normal karyotype

S. Ogawa, T. Haferlach, S. Schnittger, 2009, Haematologica.

SNP array analysis of tyrosine kinase inhibitor-resistant chronic myeloid leukemia identifies heterogeneous secondary genomic alterations.

S. Ogawa, A. Kohlmann, T. Haferlach, 2010, Blood.

Tumor necrosis factor alpha polymorphism associated with increased susceptibility to development of adult T-cell leukemia/lymphoma in human T-lymphotropic virus type 1 carriers.

H. Koeffler, K. Tsukasaki, C. W. Miller, 2001, Cancer research.

Hidden abnormalities and novel classification of t(15;17) acute promyelocytic leukemia (APL) based on genomic alterations.

S. Ogawa, D. Liang, L. Shih, 2009, Blood.

Hybrid eosinophilic-basophilic acute myeloid leukaemia diagnosed by electron microscopy

W. Hofmann, H. Koeffler, T. Ikezoe, 2007 .

Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up‐regulated in myeloid cells by 1,25‐dihydroxyvitamin D3

H. Koeffler, A. Gombart, N. Borregaard, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Metabolic gatekeeper function of B-lymphoid transcription factors

T. Graeber, R. Dickins, K. Yamamoto, 2016, Nature.

Author Correction: Metabolic gatekeeper function of B-lymphoid transcription factors

T. Graeber, R. Dickins, M. Konopleva, 2018, Nature.

Variegated clonality and rapid emergence of new molecular lesions in xenografts of acute lymphoblastic leukemia are associated with drug resistance.

S. Ogawa, D. Nowak, W. Hofmann, 2015, Experimental hematology.

Double minute chromosomes containing MYB gene and NUP214-ABL1 fusion gene in T-cell leukemia detected by single nucleotide polymorphism DNA microarray and fluorescence in situ hybridization.

S. Ogawa, H. Koeffler, N. Kawamata, 2009, Leukemia research.

Molecular allelokaryotyping of early‐stage, untreated chronic lymphocytic leukemia

S. Ogawa, S. Lehmann, M. Sanada, 2008, Cancer.