S. Adhya

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Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B.

David J Weber, Jing Lin, P. Wilder, 2006, Biochimica et biophysica acta.

HU multimerization shift controls nucleoid compaction

John A. Tainer, Carolyn A. Larabell, Michal Hammel, 2016, Science Advances.

Autoregulation of gene expression:rho

S. Adhya, R. Haber, 1987, Journal of Biosciences.

Switches in bacteriophage lambda development.

D. Court, A. Oppenheim, S. Adhya, 2005, Annual review of genetics.

Transcriptional regulation by cAMP and its receptor protein.

H. Buc, S. Busby, A. Kolb, 1993, Annual review of biochemistry.

A New Look at Bacteriophage λ Genetic Networks

D. Court, A. Oppenheim, S. Adhya, 2006 .

Bacteriophage K1-5 Encodes Two Different Tail Fiber Proteins, Allowing It To Infect and Replicate on both K1 and K5 Strains of Escherichia coli

C. Merril, S. Adhya, S. Rogers, 2001, Journal of Virology.

Bacteriophage K 1-5 Encodes Two Different Tail Fiber Proteins , Allowing It To Infect and Replicate on both K 1 and K 5 Strains of Escherichia coli

C. Merril, S. Adhya, S. Rogers, 2001 .

The galactose operon of E. coli K-12. II. A deletion analysis of operon structure and polarity.

J. Shapiro, S. Adhya, 1969, Genetics.

Inactivation of Metabolic Genes Causes Short- and Long-Range dys-Regulation in Escherichia coli Metabolic Network

Sang Jun Lee, Dinesh Kumar Barupal, D. Barupal, 2013, PloS one.

Toward a live microbial microbicide for HIV: commensal bacteria secreting an HIV fusion inhibitor peptide.

Richard A Fekete, Qi Zhao, D. Hamer, 2005, Proceedings of the National Academy of Sciences of the United States of America.

High-sensitivity bacterial detection using biotin-tagged phage and quantum-dot nanocomplexes.

Jeeseong Hwang, Kunio Nagashima, Richard A Fekete, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Noncoding RNAs Binding to the Nucleoid Protein HU in Escherichia coli

Victor Zhurkin, Feng Cui, V. Zhurkin, 2012, Journal of bacteriology.

Non-coding RNAs binding to the nucleoid protein HU in Escherichia 5 coli 6 7

V. Zhurkin, F. Cui, S. Adhya, 2012 .

Genome-Wide Transcriptional Regulation and Chromosome Structural Arrangement by GalR in E. coli

T. D. Schneider, Anne M. Stringer, Ximiao He, 2016, Front. Mol. Biosci..

Cyclic adenosine 5'-monophosphate in Escherichia coli.

I. Pastan, S. Adhya, I Pastan, 1976, Bacteriological reviews.

Control of transcription termination.

S. Adhya, M. Gottesman, 1978, Annual review of biochemistry.

Purification and properties of Gal repressor:pL-galR fusion in pKC31 plasmid vector.

S. Rudikoff, S. Adhya, A. Majumdar, 1987, The Journal of biological chemistry.

Further inducibility of a constitutive system: ultrainduction of the gal operon

S. Adhya, S. Garges, J. Tokeson, 1991, Journal of bacteriology.

Functional characterization of roles of GalR and GalS as regulators of the gal regulon

S. Adhya, S Adhya, M. Geanacopoulos, 1997, Journal of bacteriology.

Signal integration in the galactose network of Escherichia coli

Kim Sneppen, Sandeep Krishna, K. Sneppen, 2007, Molecular microbiology.

The prospect for bacteriophage therapy in Western medicine

C. Merril, S. Adhya, D. Scholl, 2003, Nature Reviews Drug Discovery.

Cooperative DNA binding of heterologous proteins: evidence for contact between the cyclic AMP receptor protein and RNA polymerase.

S. Adhya, S. Garges, J. Krakow, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Pivotal role of amino acid at position 138 in the allosteric hinge reorientation of cAMP receptor protein.

J. Kim, S. Adhya, S. Garges, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Dependence of lactose metabolism upon mutarotase encoded in the gal operon in Escherichia coli.

K. Rudd, G. Bouffard, S. Adhya, 1994, Journal of molecular biology.

Genome scale patterns of supercoiling in a bacterial chromosome

S. Adhya, A. Seshasayee, Andrei Trostel, 2016, Nature Communications.

Characterization of the binding of cAMP and cGMP to the CRP*598 mutant of the E. coli cAMP receptor protein.

S. Adhya, S. Garges, J. Krakow, 1990, Nucleic acids research.

GalR-mediated repression and activation of hybrid lacUV5 promoter: differential contacts with RNA polymerase.

N. Fujita, A. Ishihama, S. Adhya, 1998, Gene.

Single‐molecule tracking reveals that the nucleoid‐associated protein HU plays a dual role in maintaining proper nucleoid volume through differential interactions with chromosomal DNA

Jie Xiao, S. Verma, S. Adhya, 2020, Molecular microbiology.

Single molecule tracking reveals the role of transitory dynamics of nucleoid-associated protein HU in organizing the bacterial chromosome

Jie Xiao, S. Verma, S. Adhya, 2019, bioRxiv.

A-tract clusters may facilitate DNA packaging in bacterial nucleoid

V. Zhurkin, M. Tolstorukov, S. Adhya, 2005, Nucleic acids research.

Positive control.

S. Adhya, S. Garges, 1990, The Journal of biological chemistry.

Differential role of base pairs on gal promoters strength.

S. Adhya, Sankar Adhya, Phuoc Le, 2015, Journal of molecular biology.

Molecular Mechanisms of Transcription Initiation at gal Promoters and their Multi-Level Regulation by GalR, CRP and DNA Loop

S. Adhya, D. Lewis, 2015, Biomolecules.

Modulation of the two promoters of the galactose operon of Escherichia coli

S. Adhya, W. Miller, 1979, Nature.

Control of gal transcription through DNA looping: inhibition of the initial transcribing complex.

S. Adhya, H. Choy, Hyon E. Choy, 1992, Proceedings of the National Academy of Sciences of the United States of America.

RNA polymerase idling and clearance in gal promoters: use of supercoiled minicircle DNA template made in vivo.

S. Adhya, H. Choy, 1993, Proceedings of the National Academy of Sciences of the United States of America.

The non-inducible nature of super-repressors of the gal operon in Escherichia coli.

S. Roy, S. Adhya, Y. Zhou, 1995, Journal of molecular biology.

Nucleoid remodeling by an altered HU protein: reorganization of the transcription program.

S. Adhya, S. Kar, R. Edgar, 2005, Proceedings of the National Academy of Sciences of the United States of America.

HU multimerization shift controls nucleoid compaction

C. Larabell, J. Tainer, F. E. Reyes, 2017 .

Functional domains of pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli

I. Pastan, S. Adhya, Jaulang Hwang, 1987, Cell.

Relation of intracellular signal levels and promoter activities in the gal regulon of Escherichia coli.

K. Sneppen, S. Krishna, S. Semsey, 2009, Journal of molecular biology.

Organization of DNA in a bacterial nucleoid

V. Zhurkin, M. Tolstorukov, S. Adhya, 2016, BMC Microbiology.

Cytotoxic activities of a fusion protein comprised of TGFα and Pseudomonas exotoxin

I. Pastan, S. Adhya, D. Fitzgerald, 1989, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cytotoxic activity of an interleukin 2-Pseudomonas exotoxin chimeric protein produced in Escherichia coli.

I. Pastan, S. Adhya, D. Fitzgerald, 1988, Proceedings of the National Academy of Sciences of the United States of America.

A New Noncoding RNA Arranges Bacterial Chromosome Organization

V. Zhurkin, Ximiao He, E. Dimitriadis, 2015, mBio.

Bacteriophage SP6 Is Closely Related to Phages K1-5, K5, and K1E but Encodes a Tail Protein Very Similar to That of the Distantly Related P22

C. Merril, S. Adhya, D. Scholl, 2002, Journal of bacteriology.

Bacteriophage SP 6 Is Closely Related to Phages K 1-5 , K 5 , and K 1 E but Encodes a Tail Protein Very Similar to That of the Distantly Related P 22

C. Merril, S. Adhya, D. Scholl, 2002 .

Bacteriophage a spectre d'activite multiple

C. Merril, S. Adhya, D. Scholl, 2001 .

Bacteriophage Treatment Rescues Mice Infected with Multidrug-Resistant Klebsiella pneumoniae ST258

S. Adhya, B. Freedman, F. DeLeo, 2021, mBio.

Processing generates 3′ ends of RNA masking transcription termination events in prokaryotes

S. Adhya, Xun Wang, Jin He, 2019, Proceedings of the National Academy of Sciences.

Activity of immunotoxins constructed with modified Pseudomonas exotoxin A lacking the cell recognition domain.

I. Pastan, S. Adhya, D. Fitzgerald, 1988, The Journal of biological chemistry.

Activity of a recombinant fusion protein between transforming growth factor type alpha and Pseudomonas toxin.

I. Pastan, S. Adhya, D. Fitzgerald, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Escherichia coli gal operon proteins made after prophage lambda induction

C. Merril, S. Adhya, M. Gottesman, 1981, Journal of bacteriology.

Role of HU and DNA supercoiling in transcription repression: specialized nucleoprotein repression complex at gal promoters in Escherichia coli

S. Adhya, D. Lewis, M. Geanacopoulos, 1999, Molecular microbiology.

Analysis of genetic instability during mammary tumor progression using a novel selection-based assay for in vivo mutations in a bacteriophage lambda transgene target.

J. French, G. Merlino, W. Muller, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Ribosomal protein S1 promotes transcriptional cycling.

S. Adhya, S. Garges, M. V. Sukhodolets, 2006, RNA.

Structure and Function of the d-Galactose Network in Enterobacteria

S. Krishna, S. Semsey, S. Adhya, 2011, mBio.

DNA–RNA interactions are critical for chromosome condensation in Escherichia coli

V. Zhurkin, S. Adhya, Z. Qian, 2017, Proceedings of the National Academy of Sciences.

Metabolite Changes Signal Genetic Regulatory Mechanisms for Robust Cell Behavior

S. J. Lee, S. Adhya, Andrei Trostel, 2014, mBio.

Detection of conformational and net charge differences in DNA‐protein complexes by quantitative electrophoresis on polyacrylamitie‐agarose copolymer gels

C. Zwieb, S. Adhya, A. Chrambach, 1991, Electrophoresis.

(Recombinant DNA; gel retardation; bacteriophage 1 operator)

C. Zwieb, Jin Kim, S. Adhya, 1989 .

Domain II mutants of Pseudomonas exotoxin deficient in translocation.

I. Pastan, M. Willingham, S. Adhya, 1989, The Journal of biological chemistry.

A deletion analysis of prophage lambda and adjacent genetic regions.

A. Campbell, S. Adhya, P. Cleary, 1968, Proceedings of the National Academy of Sciences of the United States of America.

Improved plasmid vectors for the analysis of protein-induced DNA bending.

C. Zwieb, S. Adhya, 1994, Methods in molecular biology.

Regulatory circuits of bacteriophage lambda.

S. Adhya, S. Garges, D. Ward, 1981, Progress in nucleic acid research and molecular biology.

Harrison Echols (1933–1993)

S. Adhya, 1993, Cell.

An amino acid substitution in a capsid protein enhances phage survival in mouse circulatory system more than a 1000-fold.

C. Merril, S. Adhya, C. Vitiello, 2005, Virus research.

An arcane role of DNA in transcription activation.

S. Adhya, S. Garges, S. Ryu, 1994, Proceedings of the National Academy of Sciences of the United States of America.

DNA conformational change in Gal repressor-operator complex: involvement of central G-C base pair(s) of dyad symmetry.

S. Adhya, R. Wartell, 1988, Nucleic acids research.

Bacteriophage infection is targeted to cellular poles. Commentary

M. Kessel, S. Semsey, A. Oppenheim, 2008 .

Phage Therapy: Current Research and Applications

S. Adhya, Eric C. Keen, 2015 .

Hybrid Vigor: Importance of Hybrid λ Phages in Early Insights in Molecular Biology

S. Casjens, C. Georgopoulos, S. Adhya, 2022, Microbiology and molecular biology reviews : MMBR.

Organization of DNA in a bacterial nucleoid The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters

V. Zhurkin, M. Tolstorukov, S. Adhya, 2016 .

Site-specific DNA binding of nuclear factor I: analyses of cellular binding sites

J. Hurwitz, K. Nagata, R. Gronostajski, 1985, Molecular and cellular biology.

Evidence for two functional gal promoters in intact Escherichia coli cells.

H. Aiba, S. Adhya, B. De Crombrugghe, 1981, The Journal of biological chemistry.

Guanylate cyclase activity in Escherichia coli mutants defective in adenylate cyclase

I. Pastan, S. Adhya, V. Macchia, 1981, Journal of bacteriology.

Mutational analysis of domain I of Pseudomonas exotoxin. Mutations in domain I of Pseudomonas exotoxin which reduce cell binding and animal toxicity.

I. Pastan, S. Adhya, D. Fitzgerald, 1988, The Journal of biological chemistry.

Allosteric changes in the cAMP receptor protein of Escherichia coli: hinge reorientation.

S. Adhya, S. Garges, J. Kim, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Spiral structure of Escherichia coli HUalphabeta provides foundation for DNA supercoiling.

S. Adhya, Fusheng Guo, 2007, Proceedings of the National Academy of Sciences of the United States of America.

Gal repressor-operator-HU ternary complex: pathway of repressosome formation.

E. Dimitriadis, Siddhartha Roy, Marc S. Lewis, 2005, Biochemistry.

Repression andactivation oftranscription byGal andLacrepressors:involvement ofalphasubunit of RNApolymerase

N. Fujita, A. Ishihama, S. Adhya, 1995 .

Phosphoglucomutase Mutants of Escherichia coli K-12

S. Adhya, M. Schwartz, 1971, Journal of bacteriology.

Release of Polarity in Escherichia coli by Gene N of Phage λ: Termination and Antitermination of Transcription

S. Adhya, M. Gottesman, B. Crombrugghe, 1974 .

Release of polarity in Escherichia coli by gene N of phage lambda: termination and antitermination of transcription.

S. Adhya, M. Gottesman, B. De Crombrugghe, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Promoter occlusion: Transcription through a promoter may inhibit its activity

S. Adhya, Sankar Adhya, Max Gottesman, 1982, Cell.

A family of bacterial regulators homologous to Gal and Lac repressors.

S. Adhya, M. Weickert, M J Weickert, 1992, The Journal of biological chemistry.

Dual control for transcription of the galactose operon by cyclic AMP and its receptor protein at two interspersed promoters

R. Lauro, S. Adhya, B. Crombrugghe, 1977, Cell.

DNA sequences in gal operon override transcription elongation blocks.

M. Kashlev, S. Adhya, D. Lewis, 2008, Journal of molecular biology.

Activation and Repression of Transcription by Differential Contact: Two Sides of a Coin*

Siddhartha Roy, S. Adhya, S. Garges, 1998, The Journal of Biological Chemistry.

A mutant spacer sequence between -35 and -10 elements makes the Plac promoter hyperactive and cAMP receptor protein-independent.

Victor Zhurkin, V. Zhurkin, M. Tolstorukov, 2004, Proceedings of the National Academy of Sciences of the United States of America.

An Unsubstituted C2 Hydrogen of Adenine Is Critical and Sufficient at the –11 Position of a Promoter to Signal Base Pair Deformation*

S. Adhya, Heon-Man Lim, H. Lee, 2004, Journal of Biological Chemistry.

Asynchronous basepair openings in transcription initiation: CRP enhances the rate‐limiting step

Siddhartha Roy, S. Adhya, Mofang Liu, 2004, The EMBO journal.

DNA: Insertion Elements, Plasmids, and Episomes.

J. Shapiro, S. Adhya, A. I. Bukhari, 1977 .

Operator‐bound GalR dimers close DNA loops by direct interaction: tetramerization and inducer binding

Mark Geanacopoulos, S. Semsey, S. Adhya, 2002, The EMBO journal.

Origin and Bidirectional Orientation of DNA Replication in Coliphage Lambda

W. Szybalski, S. Adhya, W. Stevens, 1971 .

Isolation and characterization of conditional lethal mutants of Escherichia coli defective in transcription termination factor rho.

D Court, D. Court, S. Adhya, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Transcription antitermination by bacteriophage lambda N gene product.

S. Adhya, M. Gottesman, A. Das, 1980, Journal of molecular biology.

Termination and antitermination in transcription: control of gene expression.

S. Adhya, M. Gottesman, B. De Crombrugghe, 1974, Basic life sciences.

Biotin-requiring mutants of Escherichia coli K-12

S. Adhya, A. Campbell, A. del Campillo-Campbell, 1967, Journal of bacteriology.

Cyclic adenosine 5'-monophosphate in Escherichia coli

I. Pastan, S. Adhya, 1976 .

Escherichia coli K1's Capsule Is a Barrier to Bacteriophage T7

C. Merril, S. Adhya, D. Scholl, 2005, Applied and Environmental Microbiology.

The road to phage therapy

C. Merril, S. Adhya, 2006, Nature.

Therapeutic and prophylactic applications of bacteriophage components in modern medicine.

C. Merril, S. Adhya, B. Biswas, 2014, Cold Spring Harbor perspectives in medicine.

Cellular stress created by intermediary metabolite imbalances

Sang Jun Lee, S. J. Lee, S. Adhya, 2009, Proceedings of the National Academy of Sciences.

Identification of host receptor and receptor-binding module of a newly sequenced T5-like phage EPS7.

S. J. Lee, S. Adhya, S. Heu, 2008, FEMS microbiology letters.

Axiom of determining transcription start points by RNA polymerase in Escherichia coli

S. Adhya, D. Lewis, 2004, Molecular microbiology.

2004 ASM Conference on the New Phage Biology: the ‘Phage Summit’

F. Rohwer, C. Merril, A. Oppenheim, 2005, Molecular Microbiology.

Long-circulating bacteriophage as antibacterial agents.

C. Merril, S. Adhya, B. Biswas, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Interaction of spatially separated protein-DNA complexes for control of gene expression: operator conversions.

S. Adhya, R. Haber, Roberta Haber, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Bending of DNA by gene-regulatory proteins: construction and use of a DNA bending vector.

C. Zwieb, Carl Wu, Jin Kim, 1989, Gene.

Interaction of the Escherichia coli Gal repressor protein with its DNA operators in vitro.

M. Brenowitz, S. Adhya, A. Majumdar, 1990, Biochemistry.

Reconstruction of adenovirus replication origins with a human nuclear factor I binding site.

J. Hurwitz, S. Adhya, P. S. Shneidman, 1986, The Journal of biological chemistry.

Genetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis

G. Merlino, K. Tindall, W. Muller, 2002, Proceedings of the National Academy of Sciences of the United States of America.

A control element within a structural gene: The gal operon of Escherichia coli

S. Adhya, M. Irani, L. Orosz, 1983, Cell.

Effect of Rho on transcription of bacterial operons.

I. Pastan, S. Adhya, M. Gottesman, 1973, Nature: New biology.

Phage Resistance in Multidrug-Resistant Klebsiella pneumoniae ST258 Evolves via Diverse Mutations That Culminate in Impaired Adsorption

S. Gottesman, S. Adhya, V. Bliskovsky, 2020, mBio.

Molecular Basis of Phage Communication.

S. Adhya, Manoj Rajaure, 2019, Molecular cell.

Induction of the Galactose Enzymes in Escherichia coli Is Independent of the C-1-Hydroxyl Optical Configuration of the Inducer d-Galactose

S. J. Lee, S. Adhya, D. Lewis, 2008, Journal of bacteriology.

High-density functional display of proteins on bacteriophage lambda.

I. Pastan, S. Adhya, V. Chaudhary, 2003, Journal of molecular biology.

CRP-DNA complexes: inducing the A-like form in the binding sites with an extended central spacer.

V. Zhurkin, V. Ivanov, B. Chernov, 1995, Journal of molecular biology.

CRP-binding sites: evidence for two structural classes with 6-bp and 8-bp spacers.

V. Zhurkin, S. Adhya, A. Barber, 1993, Gene.

Novel “Superspreader” Bacteriophages Promote Horizontal Gene Transfer by Transformation

S. Adhya, V. Bliskovsky, J. Baker, 2017, mBio.

DNA looping in cellular repression of transcription of the galactose operon.

H. Echols, S. Adhya, R. Haber, 1990, Genes & development.

Demonstration of two operator elements in gal: in vitro repressor binding studies.

S. Adhya, A. Majumdar, 1984, Proceedings of the National Academy of Sciences of the United States of America.

A new look at bacteriophage lambda genetic networks.

D. Court, A. Oppenheim, S. Adhya, 2007, Journal of bacteriology.

New Insights into the Phage Genetic Switch: Effects of Bacteriophage Lambda Operator Mutations on DNA Looping and Regulation of PR, PL, and PRM.

S. Adhya, G. Gussin, D. Lewis, 2016, Journal of molecular biology.

Why Galactose? The Early Curiosities and the Consequences

S. Adhya, 2011 .

The antiparallel loops in gal DNA

D. Dunlap, L. Finzi, S. Semsey, 2008, Nucleic acids research.

On the role of Cro in λ prophage induction

N. Costantino, D. Court, S. Svenningsen, 2005 .

GalR represses galP1 by inhibiting the rate-determining open complex formation through RNA polymerase contact: a GalR negative control mutant.

Siddhartha Roy, S. Semsey, S. Adhya, 2004, Journal of molecular biology.

Suboperonic Regulatory Signals

S. Adhya, Sankar Adhya, 2003, Science's STKE.

Interaction of Gal repressor with inducer and operator: induction of gal transcription from repressor-bound DNA.

S. Roy, S. Adhya, Y. Zhou, 1997, Proceedings of the National Academy of Sciences of the United States of America.

The lac and gal Operons Today

S. Adhya, Sankar Adhya, 1996 .

A mutation defining ultrainduction of the Escherichia coli gal operon

S. Adhya, M. Weickert, S. Garges, 1991, Journal of bacteriology.

Glucose Effect and the Galactose Enzymes of Escherichia coli: Correlation Between Glucose Inhibition of Induction and Inducer Transport

H. Echols, S. Adhya, 1966, Journal of bacteriology.

The Developmental Switch in Bacteriophage λ: A Critical Role of the Cro Protein.

S. Adhya, Sangmi Lee, D. Lewis, 2018, Journal of molecular biology.

Multilevel autoregulation of λ repressor protein CI by DNA looping in vitro

Laura Finzi, C. Zurla, L. Finzi, 2011, Proceedings of the National Academy of Sciences.

Direct demonstration and quantification of long-range DNA looping by the λ bacteriophage repressor

David Dunlap, Carlo Manzo, Laura Finzi, 2009, Nucleic acids research.

Phages: their role in bacterial pathogenesis and biotechnology.

Matthew K. Waldor, M. Waldor, S. Adhya, 2005 .

Complete Genome Sequence of Myophage Ec_Makalu_002, Which Infects Uropathogenic Escherichia coli

S. Adhya, R. Malla, Manoj Rajaure, 2020, Microbiology Resource Announcements.

DNA trajectory in the Gal repressosome.

V. Zhurkin, S. Semsey, S. Adhya, 2004, Genes & development.

DNA-binding properties of a lac repressor mutant incapable of forming tetramers.

M. Brenowitz, S. Adhya, N. Mandal, 1991, The Journal of biological chemistry.

DNA Looping in Prophage Lambda: New Insight from Single-Molecule Microscopy

C. Zurla, C. Manzo, D. Dunlap, 2010 .

A gamut of loops: meandering DNA.

Konstantin Virnik, S. Semsey, S. Adhya, 2005, Trends in biochemical sciences.

Multipartite genetic control elements: communication by DNA loop.

S. Adhya, S Adhya, 1989, Annual review of genetics.

Spiral structure of Escherichia coli HUαβ provides foundation for DNA supercoiling

S. Adhya, Fusheng Guo, 2007, Proceedings of the National Academy of Sciences.

DNA Looping and Transcription Regulation

S. Adhya, D. Lewis, 2001 .

"Antiparallel" DNA loop in gal repressosome visualized by atomic force microscopy.

V. Zhurkin, M. Tolstorukov, Y. Lyubchenko, 2003, Journal of molecular biology.

Genetic Analysis of GalR Tetramerization in DNA Looping during Repressosome Assembly*

S. Adhya, M. Geanacopoulos, 2002, The Journal of Biological Chemistry.

Gal repressosome contains an antiparallel DNA loop

Victor B. Zhurkin, George Vasmatzis, Mark Geanacopoulos, 2001, Nature Structural Biology.

GalR mutants defective in repressosome formation.

Byungkook Lee, S. Roy, S. Adhya, 1999, Genes & development.

Repression and activation of promoter-bound RNA polymerase activity by Gal repressor.

K. Murakami, A. Ishihama, S. Adhya, 1997, Journal of molecular biology.

Repressor induced site‐specific binding of HU for transcriptional regulation

S. Adhya, S Adhya, T Aki, 1997, The EMBO journal.

Atomic force microscopic demonstration of DNA looping by GalR and HU.

Y. Lyubchenko, L. Shlyakhtenko, S. Adhya, 1997, Nucleic acids research.

Repression and activation of transcription by Gal and Lac repressors: involvement of alpha subunit of RNA polymerase.

N. Fujita, A. Ishihama, S. Adhya, 1995, The EMBO journal.

The galactose regulon of Escherichia coli

S. Adhya, M. Weickert, M J Weickert, 1993, Molecular microbiology.

Promoter resurrection by activators--a minireview.

A. Oppenheim, S. Adhya, S. Garges, 1993, Gene.

Probing the structure of gal operator-repressor complexes. Conformation change in DNA.

S. Adhya, A. Majumdar, 1987, The Journal of biological chemistry.

Sites of allosteric shift in the structure of the cyclic AMP receptor protein

S. Adhya, S. Garges, 1985, Cell.

Architecture of the Escherichia coli nucleoid

S. Verma, S. Adhya, Z. Qian, 2019, PLoS genetics.

Architectural organization in E. coli nucleoid.

S. Adhya, Mirjana Macvanin, 2012, Biochimica et biophysica acta.

Right-handed DNA Supercoiling by an Octameric Form of Histone-like Protein HU

E. Dimitriadis, S. Adhya, S. Kar, 2006, Journal of Biological Chemistry.

Separate physiological roles of specific and non-specific DNA binding of HU protein in Escherichia coli

S. Verma, S. Adhya, 2021, bioRxiv.

Recruitment of HU by piggyback: a special role of GalR in repressosome assembly.

S. Adhya, S Adhya, S. Kar, 2001, Genes & development.

Conversion of Commensal Escherichia coli K-12 to an Invasive Form via Expression of a Mutant Histone-Like Protein

S. Adhya, S. Kar, D. FitzGerald, 2011, mBio.

Histone‐like protein HU as a specific transcriptional regulator: co‐factor role in repression of gal transcription by GAL repressor

H. Choy, S. Adhya, T. Aki, 1996, Genes to cells : devoted to molecular & cellular mechanisms.

Non‐specific and specific DNA binding modes of bacterial histone, HU, separately regulate distinct physiological processes through different mechanisms

S. Adhya, Adam Harned, Kedar Narayan, 2023, Molecular microbiology.

Effect of varying the supercoiling of DNA on transcription and its regulation.

S. Adhya, Sankar Adhya, Dale E A Lewis, 2003, Biochemistry.

Positive control.

S. Adhya, S. Garges, 1990, The Journal of biological chemistry.

Transcription regulation by repressosome and by RNA polymerase contact.

S. Roy, S. Adhya, D. Lewis, 1998, Cold Spring Harbor symposia on quantitative biology.

The activity of Salmonella phage P22 gene 24 product in Escherichia coli.

S. Adhya, S. Hilliker, M. Gottesman, 1978, Virology.

Interaction of RNA polymerase and rho in transcription termination: coupled ATPase.

C. Merril, S. Adhya, A. Das, 1978, Proceedings of the National Academy of Sciences of the United States of America.

Disco-ordinate expression of the Escherichia coli gal operon after prophage lambda induction.

D. Court, C. Merril, S. Adhya, 1978, Journal of molecular biology.

The galactose operon of E. coli K-12. I. Structural and pleiotropic mutations of the operon.

J. Shapiro, S. Adhya, 1969, Genetics.

Phage Therapy in the Twenty-First Century: Facing the Decline of The Antibiotic Era; Is it Finally Time for The Age of the Phage?

S. Adhya, Sankar Adhya, Shayla Hesse, 2019, Annual review of microbiology.

Bacteriophage Therapy Rescues Mice Bacteremic from a Clinical Isolate of Vancomycin-Resistant Enterococcus faecium

C. Merril, S. Adhya, B. Biswas, 2002, Infection and Immunity.

DNA bending by negative regulatory proteins: Gal and Lac repressors.

J. Kim, C. Zwieb, S. Adhya, 1989, Genes & development.

Long-circulating bacteriophage as antibacterial agents (phageybacteriayreticuloendothelial systemytoxinsyantibiotic resistance)

C. Merril, S. Adhya, B. Biswas, 1996 .

Complete Genome Sequences of Lambdoid Phages 21, 434, and 434B and Several Lambda Hybrids

S. Casjens, C. Georgopoulos, S. Adhya, 2022, Microbiology Resource Announcements.

Studies on the mechanism of action of the gal repressor.

I. Pastan, S. Adhya, M. Gottesman, 1973, The Journal of biological chemistry.

On the role of Cro in lambda prophage induction.

N. Costantino, D. Court, S. Svenningsen, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Bacteriophage infection is targeted to cellular poles

M. Kessel, S. Semsey, A. Oppenheim, 2008, Molecular microbiology.

The Role of Gene S

S. Adhya, S. Mitra, Arup Sen, 1971 .

COMPLEMENTATION, RECOMBINATION, AND SUPPRESSION IN GALACTOSE NEGATIVE MUTANTS OF E. COLI.

H. Echols, S. Adhya, J. Reznichek, 1963, Proceedings of the National Academy of Sciences of the United States of America.

Crypticogenicity of bacteriophage λ

A. Campbell, S. Adhya, 1970 .

The Concept of Prophage

A. Campbell, S. Adhya, K. Killen, 2008 .

Selective effects of MgCl2 and temperature on the initiation of transcription at lac, gal, and lambda promoters.

I. Pastan, S. Adhya, M. Gottesman, 1975, The Journal of biological chemistry.

Host responses influence on the induction of lambda prophage

D. Court, Amnon Amir, A. Oppenheim, 2008, Molecular microbiology.

Formation of lambda lysogens by IS2 recombination: gal operon--lambda pR promoter fusions.

S. Adhya, O. Reyes, M. Gottesman, 1979, Virology.

Role of HU in Regulation of gal Promoters

S. J. Lee, S. Adhya, D. Lewis, 2010 .

Three-stage regulation of the amphibolic gal operon: from repressosome to GalR-free DNA.

S. Semsey, S. Adhya, K. Virnik, 2006, Journal of molecular biology.

Supercoiling and denaturation in Gal repressor/heat unstable nucleoid protein (HU)-mediated DNA looping

David Bensimon, David Dunlap, Vincent Croquette, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Evolution of DNA binding motifs and operators.

Ashutosh Sahu, Siddhartha Roy, Siddhartha Roy, 2002, Gene.

In Vitro Repression of the gal Promoters by GalR and HU Depends on the Proper Helical Phasing of the Two Operators*

S. Adhya, D. Lewis, 2002, The Journal of Biological Chemistry.

Effect of ethylation of operator-phosphates on Gal repressor binding. DNA contortion by repressor.

S. Adhya, A. Majumdar, Alokes Majumdar, 1989, Journal of molecular biology.

In vitro repression of the transcription of gas operon by purified gal repressor.

I. Pastan, S. Adhya, M. Gottesman, 1973, Proceedings of the National Academy of Sciences of the United States of America.

New Insights into the Phage Genetic Switch: Effects of Bacteriophage Lambda Operator Mutations on DNA Looping and Regulation of P R , P L , and P RM

S. Adhya, G. Gussin, D. Lewis, 2020 .

Galactose repressor mediated intersegmental chromosomal connections in Escherichia coli

E. Dimitriadis, S. Adhya, P. Eswaramoorthy, 2012, Proceedings of the National Academy of Sciences.

Transcription regulation by inflexibility of promoter DNA in a looped complex.

S. Adhya, P. Parrack, H. Choy, 1995, Proceedings of the National Academy of Sciences of the United States of America.

How cyclic AMP and its receptor protein act in escherichia coli

S. Adhya, S. Garges, 1982, Cell.

Cyclic AMP-induced conformational change of cyclic AMP receptor protein (CRP): intragenic suppressors of cyclic AMP-independent CRP mutations

S. Adhya, S. Garges, 1988, Journal of bacteriology.

A phage display system designed to detect and study protein–protein interactions

A. Oppenheim, S. Adhya, G. Prag, 2008, Molecular microbiology.

The hydrolysis of Tween 80 by vibrios and aeromonads.

S. Adhya, A. Chakrabarty, M. Pramanik, 1970, The Journal of applied bacteriology.

Activation of transcription at specific promoters by glycerol.

I. Pastan, S. Adhya, M. Gottesman, 1974, The Journal of biological chemistry.

Role of allosteric changes in cyclic AMP receptor protein function.

S. Adhya, S. Garges, S. Ryu, 1995, Sub-cellular biochemistry.

λ Recombineering Used to Engineer the Genome of Phage T7

D. Court, S. Adhya, A. Rattray, 2020, Antibiotics.

Regulation of the pR operon of bacteriophage lambda.

C. Debouck, S. Adhya, M. Gottesman, 1983, Journal of molecular and applied genetics.

Control of transcription of gal repressor and isorepressor genes in Escherichia coli

S. Adhya, M. Weickert, M J Weickert, 1993, Journal of bacteriology.

Effects of dimethylsulfoxide on the E. coli gal operon and on bacteriophage lambda in vivo.

I. Pastan, S. Adhya, M. Gottesman, 1974, Cell.

A “master” in base unpairing during isomerization of a promoter upon RNA polymerase binding

Siddhartha Roy, S. Adhya, Heon-Man Lim, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Conversion of Commensal Escherichia coli K-12 to an Invasive Form via Expression of a Mutant Histone-Like Protein

S. Adhya, S. Kar, D. FitzGerald, 2011, mBio.

Bacteriophage lambda hin function. II. Enhanced stability of lambda messenger RNA.

D Court, D. Court, S. Adhya, 1980, Journal of molecular biology.

Cyclic-AMP-dependent switch in initiation of transcription from the two promoters of the Escherichia coli gal operon: identification and assay of 5'-triphosphate ends of mRNA by GTP:RNA guanyltransferase

S. Adhya, M. Irani, R. Musso, 1989, Journal of bacteriology.

lacP1 Promoter with an Extended – 10 Motif

S. Adhya, S. Garges, Mofang Liu, 2004, Journal of Biological Chemistry.

Isorepressor of the gal regulon in Escherichia coli.

S. Adhya, M. Weickert, M J Weickert, 1992, Journal of molecular biology.

Suppression of polarity of insertion mutations in the gal operon and N mutations in bacteriophage lambda

S. Adhya, O. Reyes, M. Gottesman, 1976, Journal of bacteriology.

Dawn of the Postantibiotic Era Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the

R. Rappuoli, F. Fang, S. Hultgren, 2014 .

Nucleoid remodeling during environmental adaptation is regulated by HU-dependent DNA bundling

C. Larabell, S. Verma, M. Hammel, 2020, Nature Communications.

DNA repeat sequences: diversity and versatility of functions

S. Adhya, Z. Qian, 2017, Current Genetics.

Transcription Termination Regulates Gene Expression

D. Court, S. Adhya, M. Gottesman, 1976 .

The nucleotide sequence of the gal T gene of Escherichia coli.

P. Frey, W. Reznikoff, S. Adhya, 1987, Nucleic acids research.

The pleiotropic ts15 mutation of E. coli is an IS1 insertion in the rho structural gene.

S. Adhya, A. Das, E. Gulletta, 1983, Genetics.

Chlamydia pneumoniae Secretion of a Protease-Like Activity Factor for Degrading Host Cell Transcription Factors Required for Major Histocompatibility Complex Antigen Expression

C. Merril, S. Adhya, B. Biswas, 2002 .

Illegitimate recombination in bacteria and bacteriophage.

R. Weisberg, S. Adhya, 1977, Annual review of genetics.

Evidence for two promoters upstream of the pts operon: regulation by the cAMP receptor protein regulatory complex.

S. Roseman, S. Adhya, S. Garges, 1992, Proceedings of the National Academy of Sciences of the United States of America.

On the role of Cro in lambda prophage induction

N. Costantino, D. Court, S. Svenningsen, 2018 .

Dominant Negative Autoregulation Limits Steady-State Repression Levels in Gene Networks

Kim Sneppen, Sandeep Krishna, K. Sneppen, 2009, Journal of bacteriology.

RNA polymerase and associated factors

S. Adhya, S. Garges, 1996 .

Role of domain II of Pseudomonas exotoxin in the secretion of proteins into the periplasm and medium by Escherichia coli.

Y H Xu, I. Pastan, S. Adhya, 1988, Proceedings of the National Academy of Sciences of the United States of America.

RNA Polymerase

N. Fujita, S. Adhya, T. Aki, 2020, Definitions.

Organization of DNA in a bacterial nucleoid

V. Zhurkin, M. Tolstorukov, S. Adhya, 2016, BMC Microbiology.

THE ROLE OF RHO IN TRANSCRIPTION TERMINATION IN E. COLI

D. Court, S. Adhya, M. Gottesman, 1978 .

Independence of gene N and tof functions of bacteriophage lambda.

D. Court, S. Adhya, M. Gottesman, 1977, Journal of molecular biology.

Cyclic AMP-dependent constitutive expression of gal operon: use of repressor titration to isolate operator mutations.

S. Busby, S. Adhya, T. Taniguchi, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Genomic analysis of bacteriophages SP6 and K1-5, an estranged subgroup of the T7 supergroup.

J. Rush, C. Merril, S. Adhya, 2004, Journal of molecular biology.

Dominant Negative Autoregulation Limits Steady-State Repression Levels in Gene Networks

K. Sneppen, S. Semsey, S. Adhya, 2009, Journal of bacteriology.

Novel tethered particle motion analysis of CI protein-mediated DNA looping in the regulation of bacteriophage lambda

C. Zurla, D. Dunlap, L. Finzi, 2006 .