D. Liebermann

D. Liebermann, A. Abdollahi, K. Lord, 1991, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways.

B. Hoffman, D. Liebermann, R. Steinman, 1995, Oncogene.

Gadd45 in modulation of solid tumors and leukemia.

B. Hoffman, D. Liebermann, 2013, Advances in experimental medicine and biology.

Progression of the myeloid differentiation program is dominant to transforming growth factor-beta 1-induced apoptosis in M1 myeloid leukemic cells.

John Calvin Reed, B. Hoffman, D. Liebermann, 1994, Blood.

Gadd 45 in stress signaling

B. Hoffman, D. Liebermann, 2008 .

Distinct mechanisms are utilized to induce stress sensor gadd45b by different stress stimuli

B. Hoffman, D. Liebermann, Steven D. Zumbrun, 2009, Journal of cellular biochemistry.

Role of gadd45 in myeloid cells in response to hematopoietic stress.

B. Hoffman, D. Liebermann, 2007, Blood cells, molecules & diseases.

Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress.

A. Fornace, B. Hoffman, D. Liebermann, 2010, Cancer research.

Gadd45 stress sensors in malignancy and leukemia.

B. Hoffman, D. Liebermann, A. Mohamed-Hadley, 2011, Critical reviews in oncogenesis.

The c‐myc apoptotic response is not intrinsic to blocking terminal myeloid differentiation

B. Hoffman, D. Liebermann, S. D’Angelo, 2008, Journal of cellular physiology.

Conserved DNA methylation in Gadd45a-/- mice

C. Sapienza, B. Hoffman, D. Liebermann, 2009, Epigenetics.

Sequences from sea urchin TU transposons are conserved among multiple eucaryotic species, including humans

L. Kedes, S. Cohen, D. Liebermann, 1986, Molecular and cellular biology.

Role of c-myc in myeloid differentiation, growth arrest and apoptosis.

B. Hoffman, D. Liebermann, M. Selvakumaran, 1996, Current topics in microbiology and immunology.

Lineage-specific regulation of hematopoiesis by HOX-B8 (HOX-2.4): inhibition of granulocytic differentiation and potentiation of monocytic differentiation.

B. Hoffman, D. Liebermann, K. Krishnaraju, 1997, Blood.

Human homologs of TU transposon sequences: polypurine/polypyrimidine sequence elements that can alter DNA conformation in vitro and in vivo

L. Kedes, S. Cohen, D. Liebermann, 1986, Molecular and cellular biology.

Activated abl oncogenes and apoptosis: differing responses of transformed myeloid progenitor cell lines.

B. Hoffman, D. Liebermann, S. K. Shore, 1996, Blood.

Inhibiting calpain 1 and 2 in cyclin G associated kinase–knockout mice mitigates podocyte injury

Zhenhai Zhang, D. Liebermann, L. Greene, 2020, JCI insight.

Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation

J. Brugge, D. Liebermann, M. DeMarco, 1991 .

Gadd45a stress signaling regulates sFlt‐1 expression in preeclampsia

B. Hoffman, D. Liebermann, Yajue Huang, 2009, Journal of cellular physiology.

Preeclampsia‐associated stresses activate Gadd45a signaling and sFlt‐1 in placental explants

B. Hoffman, D. Liebermann, O. Geifman‐Holtzman, 2013, Journal of cellular physiology.

The carboxyl terminus of the murine MyD116 gene substitutes for the corresponding domain of the gamma(1)34.5 gene of herpes simplex virus to preclude the premature shutoff of total protein synthesis in infected human cells

B. Hoffman, D. Liebermann, B. Roizman, 1996, Journal of virology.

Cell signalling (communication arising): Cell survival and a Gadd45-factor deficiency

A. Fornace, B. Hoffman, D. Liebermann, 2003, Nature.

p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced apoptosis.

C. Guillouf, F. Rosselli, E. Moustacchi, 1995, Oncogene.

Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation

J. Brugge, D. Liebermann, S. M. Thomas, 1991, Molecular and cellular biology.

Deregulated E2F-1 blocks terminal differentiation and loss of leukemogenicity of M1 myeloblastic leukemia cells without abrogating induction of p15INK4B and p16INK4A

B. Hoffman, D. Liebermann, A. Amanullah, 2000 .

The zinc finger transcription factor Egr-1 potentiates macrophage differentiation of hematopoietic cells

B. Hoffman, D. Liebermann, K. Krishnaraju, 1995, Molecular and cellular biology.

Tsp transposons: a heterogeneous family of mobile sequences in the genome of the sea urchin Strongylocentrotus purpuratus

L. Kedes, J. B. Cohen, D. Liebermann, 1985, Molecular and cellular biology.

Apoptotic signaling by c-MYC

B. Hoffman, D. Liebermann, D A Liebermann, 2008, Oncogene.

Regulation of gene expression by tumor promoters. II. Control of cell shape and developmental programs for macrophages and granulocytes in human myeloid leukemic cells

L. Sachs, D. Liebermann, B. Hoffman‐Liebermann, 1981, International journal of cancer.

Gadd45a and Gadd45b modulate innate immune functions of granulocytes and macrophages by differential regulation of p38 and JNK signaling

B. Hoffman, D. Liebermann, D. Salerno, 2012, Journal of cellular physiology.

Prostate cancer: JunD, Gadd45a and Gadd45g as therapeutic targets

B. Hoffman, D. Liebermann, 2011, Cell cycle.

Cell Cycle News & Views Redundancy in response to DNA damage : The key to protection of genome integrity

B. Hoffman, D. Liebermann, 2011 .

Increased Placental Telomerase mRNA in Hypertensive Disorders of Pregnancy

J. Gaughan, B. Hoffman, D. Liebermann, 2010, Hypertension in pregnancy.

Blocking c-Myc and Max expression inhibits proliferation and induces differentiation of normal and leukemic myeloid cells.

B. Hoffman, D. Liebermann, M. Selvakumaran, 1995, Oncogene.

Interleukin-6- and leukemia inhibitory factor-induced terminal differentiation of myeloid leukemia cells is blocked at an intermediate stage by constitutive c-myc

D. Liebermann, B. Hoffman‐Liebermann, 1991, Molecular and cellular biology.

Molecular controls of apoptosis: differentiation/growth arrest primary response genes, proto-oncogenes, and tumor suppressor genes as positive & negative modulators.

B. Hoffman, D. Liebermann, 1994, Oncogene.

Gadd45b deficiency promotes premature senescence and skin aging

B. Hoffman, D. Liebermann, A. Magimaidas, 2016, Oncotarget.

RAPID COMMUNICATION Myeloblastic Leukemia Cells Conditionally Blocked by Myc-Estrogen Receptor Chimeric Transgenes for Terminal Differentiation Coupled to Growth Arrest and Apoptosis

D. Liebermann, B. Hoffman‐Liebermann, 2003 .

Interferon regulatory factor-1 myelodysplasia and leukemia.

B. Hoffman, D. Liebermann, 2006, Leukemia research.

Structure andUnusual Characteristics ofaNewFamily of Transposable Elements intheSeaUrchin Strongylocentrotus purpuratus

Stanley N Cohen, D. Liebermann, R. Maxson, 1985 .

Myeloid progenitors on demand

B. Hoffman, D. Liebermann, 2006, Nature Methods.

Dissection of the immediate early response of myeloid leukemia cells to terminal differentiation and growth inhibitory stimuli.

D. Liebermann, A. Abdollahi, K. Lord, 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Factors Are Positive Regulators of Myeloid Differentiation

D. Liebermann, A. Abdollahi, K. A. Lord, 2022 .

granulocyte and erythroid lineages progenitor cells along the macrophage lineage at the expense of the Early growth response gene 1 stimulates development of hematopoietic

B. Hoffman, D. Liebermann, K. Krishnaraju, 2013 .

The Zinc Finger Transcription Factor Egr-1 Activates Macrophage Differentiation in M1 Myeloblastic Leukemia Cells

B. Hoffman, D. Liebermann, K. Krishnaraju, 1998 .

Control mechanisms regulating gene expression during normal differentiation of myeloid leukemic cells: differentiation defective mutants blocked in mRNA production and mRNA translation.

L. Sachs, D. Liebermann, B. Hoffman‐Liebermann, 1981, Developmental biology.

Molecular dissection of differentiation in normal and leukemic myeloblasts: separately programmed pathways of gene expression.

L. Sachs, D. Liebermann, B. Hoffman‐Liebermann, 1980, Developmental biology.

Suppression of c-myc and c-myb is tightly linked to terminal differentiation induced by IL6 or LIF and not growth inhibition in myeloid leukemia cells.

D. Liebermann, B. Hoffman‐Liebermann, 1991, Oncogene.

Good and bad IRF-1: role in tumor suppression versus autoimmune disease.

B. Hoffman, D. Liebermann, 2009, Leukemia research.

CR6: A third member in the MyD118 and Gadd45 gene family which functions in negative growth control

Wei Zhang, B. Hoffman, D. Liebermann, 1999, Oncogene.

Loss of Gadd45b accelerates BCR-ABL-driven CML

B. Hoffman, D. Liebermann, Xiaojin Sha, 2018, Oncotarget.

The zinc finger transcription factor Egr-1 is essential for and restricts differentiation along the macrophage lineage

D. Liebermann, Hung Q. Nguyen, B. Hoffman‐Liebermann, 1993, Cell.

Deregulated c-myb disrupts interleukin-6- or leukemia inhibitory factor-induced myeloid differentiation prior to c-myc: role in leukemogenesis

D. Liebermann, M. Selvakumaran, B. Hoffman‐Liebermann, 1992, Molecular and cellular biology.

Complexity of the immediate early response of myeloid cells to terminal differentiation and growth arrest includes ICAM-1, Jun-B and histone variants.

D. Liebermann, K. Lord, B. Hoffman‐Liebermann, 1990, Oncogene.

Proto-oncogene expression and dissection of the myeloid growth to differentiation developmental cascade.

D. Liebermann, B. Hoffman‐Liebermann, 1989, Oncogene.

Gadd45 Stress Sensor Genes

B. Hoffman, D. Liebermann, 2013, Advances in Experimental Medicine and Biology.

Regulation and role of different macrophage‐ and granulocyte‐inducing proteins in normal and leukemic myeloid cells

L. Sachs, D. Liebermann, B. Hoffman‐Liebermann, 1982, International journal of cancer.

Co-regulation of type C RNA virus production and cell differentiation in myeloid leukemic cells

L. Sachs, D. Liebermann, 1978, Cell.

Type C RNA virus production and cell competence for normal differentiation in myeloid leukaemic cells

L. Sachs, D. Liebermann, 1977, Nature.

Cell cycle arrest.

P. Fisher, D. Liebermann, R. Steinman, 1995, Science.

Induction of p21 (WAF-1/CIP1) during differentiation.

C. Guillouf, B. Hoffman, D. Liebermann, 1994, Oncogene.

Regulation of endogenous type C virus expression during normal myeloid cell differentiation. Evidence for a role in promoting myeloid cell proliferation and differentiation.

L. Sachs, D. Liebermann, B. Hoffman‐Liebermann, 1980, Virology.

Increase of normal myeloblast viability and multiplication without blocking differentiation by type C RNA virus from myeloid leukemic cells.

L. Sachs, D. Liebermann, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.

John Calvin Reed, S. Krajewski, T. Miyashita, 1994, Oncogene.

Stress sensor Gadd45 genes as therapeutic targets in cancer.

Barbara Hoffman, B. Hoffman, D. Liebermann, 2009, Cancer therapy.

Gadd45 in the response of hematopoietic cells to genotoxic stress.

Barbara Hoffman, B. Hoffman, D. Liebermann, 2007, Blood cells, molecules & diseases.

Eliciting Growth Arrest

A. Fornace, J. Jackman, D. Liebermann, 2006 .

Myeloid differentiation (MyD) primary response genes in hematopoiesis.

B. Hoffman, D. Liebermann, 2003, Oncogene.

Myeloid differentiation (MyD) primary response genes in hematopoiesis

B. Hoffman, D. Liebermann, 2002, Oncogene.

Myeloid Differentiation (MyD)/Growth Arrest DNA Damage (GADD) genes in tumor suppression, immunity and inflammation

B. Hoffman, D. Liebermann, 2002, Leukemia.

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth

K. Kohn, A. Fornace, F. Carrier, 1994, Molecular and cellular biology.

Differentiation primary response genes and proto‐oncogenes as positive and negative regulators of terminal hematopoietic cell differentiation

B. Hoffman, D. Liebermann, 1994, Stem cells.

Genotoxic‐Stress‐Response Genes and Growth‐Arrest Genes

A. Fornace, J. Jackman, D. Liebermann, 1992, Annals of the New York Academy of Sciences.

The novel primary response gene MyD118 and the proto-oncogenes myb, myc, and bcl-2 modulate transforming growth factor beta 1-induced apoptosis of myeloid leukemia cells.

John Calvin Reed, R. T. Sjin, B. Hoffman, 1994, Molecular and cellular biology.

growth arrest and apoptosis receptor chimeric transgenes for terminal differentiation coupled to Myeloblastic leukemia cells conditionally blocked by myc-estrogen

D. Liebermann, M. Selvakumaran, B. Hoffman‐Liebermann, 2011 .

Myeloblastic leukemia cells conditionally blocked by myc-estrogen receptor chimeric transgenes for terminal differentiation coupled to growth arrest and apoptosis.

D. Liebermann, M. Selvakumaran, B. Hoffman‐Liebermann, 1993, Blood.

The proto-oncogene c-myc in hematopoietic development and leukemogenesis

Barbara Hoffman, B. Hoffman, D. Liebermann, 2002, Oncogene.

13-Induced Apoptosis of Myeloid Leukemia Cells

D. Liebermann, Hsueh-Kung Lin, Muthu, 2022 .

Deregulated c-Myc prematurely recruits both Type I and II CD95/Fas apoptotic pathways associated with terminal myeloid differentiation

B. Hoffman, D. Liebermann, A. Amanullah, 2002, Oncogene.

An unusual transposon with long terminal inverted repeats in the sea urchin Strongylocentrotus purpuratus

Stanley N Cohen, L. Kedes, D. Liebermann, 1983, Nature.

Proto-oncogenes of the fos/jun family of transcription factors are positive regulators of myeloid differentiation

D. Liebermann, A. Abdollahi, K A Lord, 1993, Molecular and cellular biology.

Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis.

P. O'Connor, A. Fornace, I. Bae, 1994, Oncogene.

The zinc finger transcription factor Egr-1 activates macrophage differentiation in M1 myeloblastic leukemia cells.

B. Hoffman, D. Liebermann, K. Krishnaraju, 1998, Blood.

The proto-oncogene c-myc blocks myeloid differentiation independently of its target gene ornithine decarboxylase.

B. Hoffman, D. Liebermann, M. Selvakumaran, 1996, Blood.

p53 Induced Growth Arrest versus Apoptosis and its Modulation by Survival Cytokines

B. Hoffman, D. Liebermann, D. Vesely, 2007, Cell cycle.

Ectopic expression of MyD118/Gadd45/CR6 (Gadd45β/α/γ) sensitizes neoplastic cells to genotoxic stress-induced apoptosis

Wei Zhang, B. Hoffman, D. Liebermann, 2001 .

The proto-oncogene c-myc and apoptosis

B. Hoffman, D. Liebermann, 1998, Oncogene.

p53-independent apoptosis associated with c-Myc-mediated block in myeloid cell differentiation

B. Hoffman, D. Liebermann, A. Amanullah, 2000, Oncogene.

TU elements: a heterogeneous family of modularly structured eucaryotic transposons

L. Kedes, S. Cohen, D. Liebermann, 1985, Molecular and cellular biology.

Gadd45a suppresses Ras-driven mammary tumorigenesis by activation of c-Jun NH2-terminal kinase and p38 stress signaling resulting in apoptosis and senescence.

Barbara Hoffman, B. Hoffman, D. Liebermann, 2006, Cancer research.

abrogates the c-Myc block in terminal myeloid differentiation Fos modulates myeloid cell survival and differentiation and partially

D. Liebermann, A. Amanullah, M. Shafarenko, 2013 .

Fos modulates myeloid cell survival and differentiation and partially abrogates the c-Myc block in terminal myeloid differentiation.

B. Hoffman, D. Liebermann, A. Amanullah, 2004, Blood.

AP-1 (Fos/Jun) transcription factors in hematopoietic differentiation and apoptosis.

B. Hoffman, D. Liebermann, B. Hoffman, 1998, International journal of oncology.

Cdc25A stability is controlled by the ubiquitin-proteasome pathway during cell cycle progression and terminal differentiation

B. Hoffman, D. Liebermann, R. Bernardi, 2000, Oncogene.

1-induced apoptosis of myeloid leukemia cells. modulate transforming growth factor beta the proto-oncogenes myb, myc, and bcl-2 The novel primary response gene MyD118 and

John Calvin Reed, R. T. Sjin, B. Hoffman, 2013 .

Activation of the Jak3 pathway is associated with granulocytic differentiation of myeloid precursor cells.

S. Rane, E. Reddy, B. Hoffman, 2002, Blood.

Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation.

Albert J. Fornace, Barbara Hoffman, Anita B. Roberts, 2003, The Journal of biological chemistry.

Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice.

J. Locker, B. Hoffman, D. Liebermann, 2011, The Journal of clinical investigation.

Comparative analysis of the genetic structure and chromosomal mapping of the murine Gadd45g/CR6 gene.

A. Fornace, B. Hoffman, D. Liebermann, 2003, DNA and cell biology.

Regulation of gene expression by tumor promoters. III. Complementation of the developmental program in myeloid leukemic cells by regulating mRNA production and mRNA translation

L. Sachs, D. Liebermann, B. Hoffman‐Liebermann, 1981, International journal of cancer.

Nucleotide sequence and expression of a cDNA encoding MyD88, a novel myeloid differentiation primary response gene induced by IL6.

D. Liebermann, K A Lord, B Hoffman-Liebermann, 1990, Oncogene.

Transcriptional regulation of myeloid differentiation primary response (MyD) genes during myeloid differentiation is mediated by nuclear factor Y.

R. T. Sjin, B. Hoffman, D. Liebermann, 2002, Blood.

Genetic Deletion of gadd45b, a Regulator of Active DNA Demethylation, Enhances Long-Term Memory and Synaptic Plasticity

J. Sweatt, D. Liebermann, Faraz A. Sultan, 2012, The Journal of Neuroscience.

Egr-1 abrogates the block imparted by c-Myc on terminal M1 myeloid differentiation.

B. Hoffman, D. Liebermann, M. Shafarenko, 2004, Blood.

Terminal Myeloid Differentiation is Uncoupled from Cell Cycle Arrest

B. Hoffman, D. Liebermann, J. Gibbs, 2007, Cell cycle.

Gadd45a deficiency accelerates BCR-ABL driven chronic myelogenous leukemia

B. Hoffman, D. Liebermann, T. Skorski, 2017, Oncotarget.

First trimester noninvasive fetal RHD genotyping using maternal dried blood spots

B. Hoffman, D. Liebermann, O. Geifman‐Holtzman, 2017, Prenatal diagnosis.

Gadd45b knockout mice exhibit selective deficits in hippocampus-dependent long-term memory.

T. Abel, B. Hoffman, D. Liebermann, 2012, Learning & memory.

MyD genes in negative growth control

B. Hoffman, D. Liebermann, 1998, Oncogene.

Gadd45 in Senescence.

D. Liebermann, M. Zaidi, 2022, Advances in experimental medicine and biology.

Sequence of MyD116 cDNA: a novel myeloid differentiation primary response gene induced by IL6.

D. Liebermann, K. Lord, B. Hoffman‐Liebermann, 1990, Nucleic acids research.

Targeting RSPO3-LGR4Sig naling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia

B. Vick, I. Jeremias, K. Spiekermann, 2020 .

Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia.

B. Vick, I. Jeremias, K. Spiekermann, 2020, Cancer cell.

Nuclear control of neurite induction in neuroblastoma cells.

L. Sachs, D. Liebermann, 1978, Experimental cell research.

Deregulated E2F-1 blocks terminal differentiation and loss of leukemogenicity of M1 myeloblastic leukemia cells without abrogating induction of p15(INK4B) and p16(INK4A).

D. Liebermann, B. Hoffman, A. Amanullah, 2000, Blood.

Genetic programs of myeloid cell differentiation.

D. Liebermann, B. Hoffman‐Liebermann, 1994, Current opinion in hematology.

Prevalence, causes, and characterization of factor XI inhibitors in patients with inherited factor XI deficiency.

D. Steinberg, Christine A. Lee, R. T. Sjin, 2003, Blood.

Comparative analysis of the genetic structure and chromosomal location of the murine MyD118 (Gadd45beta) gene.

B. Hoffman, D. Liebermann, A. Balliet, 2001, DNA and cell biology.

Gadd45a levels in human breast cancer are hormone receptor dependent

B. Hoffman, D. Liebermann, A. Willis, 2013, Journal of Translational Medicine.

Ectopic expression of MyD118/Gadd45/CR6 (Gadd45beta/alpha/gamma) sensitizes neoplastic cells to genotoxic stress-induced apoptosis.

B. Hoffman, D. Liebermann, W. Zhang, 2001, International journal of oncology.

Cell signalling: cell survival and a Gadd45-factor deficiency.

A. Fornace, B. Hoffman, D. Liebermann, 2003, Nature.

Proto-oncogenes of the fos/jun family of transcription factors are positive regulators of myeloid differentiation

D. Liebermann, A. Abdollahi, K. Lord, 1993 .

Plus Fibronectin-activated Peripheral Blood Eosinophils Α Factor- Colony-stimulating Factor Messenger Rna Stabilization in Tumor Necrosis Extracellular Signal-regulated Kinase Mediates Granulocyte-macrophage

R. T. Sjin, B. Hoffman, D. Liebermann, 2022 .

Phosphatidylinositol 3-kinase/Akt signaling mediates interleukin-6 protection against p53-induced apoptosis in M1 myeloid leukemic cells

B. Hoffman, D. Liebermann, D. Vesely, 2007, Oncogene.

Cell signalling: cell survival and a Gadd45-factor deficiency.

A. Fornace, B. Hoffman, D. Liebermann, 2003, Nature.

An unusual transposon with long terminal inverted repeats in the sea urchin Strongylocentrotus purpuratus

Stanley N Cohen, L. Kedes, D. Liebermann, 1983, Nature.

Matsusaka''s big theorem

D. Mumford, D. Liebermann, 1974 .

Cd3/tcr Signaling Engagement of Ilt2/cd85j in Sezary Syndrome Cells Inhibits Their

B. Hoffman, D. Liebermann, M. Nikolova, 2002 .