J. Grippo

发表

Characterization of the chimeric retinoic acid receptor RARα/VDR

K. Ozato, P. Abarzúa, S. Pemrick, 1998, Leukemia.

Inhibition of mutated, activated BRAF in metastatic melanoma.

K. Flaherty, J. Sosman, A. Ribas, 2010, The New England journal of medicine.

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Kam Y. J. Zhang, K. Flaherty, J. Sosman, 2010, Nature.

RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models.

D. Heimbrook, J. Grippo, B. Higgins, 2010, Cancer research.

The retinoid receptors.

S. Pemrick, J. Grippo, D. A. Lucas, 1994, Leukemia.

9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα

J. Grippo, A. Lovey, A. Levin, 1992, Nature.

A Comprehensive Hepatitis C Viral Kinetic Model

M. Lavielle, J. Grippo, P. Jacqmin, 2010 .

Safety, Tolerability, and Pharmacokinetics of Ribavirin in Hepatitis C Virus-Infected Patients with Various Degrees of Renal Impairment

J. Grippo, K. Nieforth, P. Martin, 2013, Antimicrobial Agents and Chemotherapy.

Clinical Pharmacokinetics of Vemurafenib

J. Grippo, D. Heinzmann, Weijiang Zhang, 2017, Clinical Pharmacokinetics.

Piragliatin (RO4389620), a novel glucokinase activator, lowers plasma glucose both in the postabsorptive state and after a glucose challenge in patients with type 2 diabetes mellitus: a mechanistic study.

T. Heise, C. Kapitza, A. Avogaro, 2010, The Journal of clinical endocrinology and metabolism.

Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells

J. Grippo, L. Gudas, G. Larosa, 1989, Molecular and cellular biology.

Proof that the endogenous, heat-stable glucocorticoid receptor-activating factor is thioredoxin.

A. Holmgren, J. Grippo, W. Pratt, 1985, The Journal of biological chemistry.

Pharmacokinetically Guided Phase 1 Trial of the IGF-1 Receptor Antagonist RG1507 in Children with Recurrent or Refractory Solid Tumors

J. Grippo, C. Herzog, F. Balis, 2010, Clinical Cancer Research.

Regulation of retinoid-induced differentiation in embryonal carcinoma PCC4.aza1R cells: effects of retinoid-receptor selective ligands.

J. Grippo, M. Dawson, C. Nervi, 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Effect of peginterferon alfa‐2a (40KD) on cytochrome P450 isoenzyme activity

J. Grippo, Zhi-xin Xu, B. Brennan, 2013, British journal of clinical pharmacology.

The pharmacokinetics of peginterferon alfa‐2a and ribavirin in African American, Hispanic and Caucasian patients with chronic hepatitis C

C. Hagedorn, J. Grippo, T. Marbury, 2012, Alimentary pharmacology & therapeutics.

Evaluation of the absolute bioavailability of pegylated interferon alfa-2a after subcutaneous administration to healthy male volunteers: an open-label, randomized, parallel-group study.

J. Grippo, Zhi-xin Xu, B. Brennan, 2012, Clinical therapeutics.

Characterization of Glucokinase Regulatory Protein-deficient Mice*

J. Grippo, M. Magnuson, F. Matschinsky, 2000, The Journal of Biological Chemistry.

Discovery of piragliatin--first glucokinase activator studied in type 2 diabetic patients.

J. Grippo, F. Matschinsky, P. Mahaney, 2012, Journal of medicinal chemistry.

Pharmacokinetics and response of obese patients with chronic hepatitis C treated with different doses of PEG-IFN alpha-2a (40KD) (PEGASYS).

J. Grippo, B. Bressler, E. Heathcote, 2009, British journal of clinical pharmacology.

All-trans-retinoic acid and hexamethylene bisacetamide (HMBA) regulate TGF-alpha and Hst-1/kFGF expression in differentiation sensitive but not in resistant human teratocarcinomas.

E. Dmitrovsky, J. Baselga, W. Miller, 1994, Differentiation; research in biological diversity.

Binding of 9-cis-retinoic acid and all-trans-retinoic acid to retinoic acid receptors alpha, beta, and gamma. Retinoic acid receptor gamma binds all-trans-retinoic acid preferentially over 9-cis-retinoic acid.

J. Grippo, A. Levin, G. Allenby, 1994, The Journal of biological chemistry.

Distinct binding determinants for 9-cis retinoic acid are located within AF-2 of retinoic acid receptor alpha

P. Abarzúa, J. Grippo, A. Levin, 1994, Molecular and cellular biology.

Inhibition of estrogen-responsive gene activation by the retinoid X receptor beta: evidence for multiple inhibitory pathways

S. Hirschfeld, K. Ozato, M. Marks, 1993, Molecular and cellular biology.

Obesity genes: molecular genetic approaches to drug target identification.

J. Grippo, P. Burn, 1998, Farmaco.

Dominant negative retinoid X receptor beta inhibits retinoic acid-responsive gene regulation in embryonal carcinoma cells

S. Minucci, K. Ozato, M. Marks, 1994, Molecular and cellular biology.

Retinoic acid induces down-regulation of several growth factors and proto-oncogenes in a human embryonal cancer cell line.

E. Dmitrovsky, W. Miller, J. Grippo, 1990, Oncogene.

The Regulation of the Expression of Genes Encoding Basement Membrane Proteins during the Retinoic Acid‐Associated Differentiation of Murine Teratocarcinoma Cells a

J. Grippo, K. W. Kim, L. Gudas, 1990, Annals of the New York Academy of Sciences.

RXR-dependent and RXR-independent transactivation by retinoic acid receptors.

P. Lemotte, C. Carlberg, J. Grippo, 1993, Nucleic acids research.

Crystal Structure of Human Liver Glucokinase Bound to a Small Molecule Allosteric Activator

U. Kammlott, C. Lukacs, J. Grippo, 2004 .

Discovery and Actions of Glucokinase Activators

J. Grippo, F. Matschinsky, J. Grimsby, 2004 .

Discovery, structure-activity relationships, pharmacokinetics, and efficacy of glucokinase activator (2R)-3-cyclopentyl-2-(4-methanesulfonylphenyl)-N-thiazol-2-yl-propionamide (RO0281675).

A. Railkar, J. Grippo, F. Matschinsky, 2010, Journal of medicinal chemistry.

Inhibition of Estrogen-Responsive Gene Activation by the Retinoid X Receptor β: Evidence for Multiple Inhibitory Pathways

W. Wahli, J. Grippo, E. Martinez, 1993 .

2,3-Disubstituted acrylamides as potent glucokinase activators.

J. Grippo, A. Sidduri, J. Lou, 2010, Bioorganic & medicinal chemistry letters.

A Comprehensive Hepatitis C Viral Kinetic Model Explaining Cure

M Lavielle, M. Lavielle, J. Grippo, 2010, Clinical pharmacology and therapeutics.

The heat-stable cytosolic factor that promotes glucocorticoid receptor binding to DNA is neither thioredoxin nor ribonuclease.

A. Holmgren, J. Grippo, W. Pratt, 1987, Journal of steroid biochemistry.

Safety, tolerability, pharmacokinetics, and pharmacodynamics of a TLR7 agonist prodrug RO6870868 in healthy volunteers

E. Calleja, J. Grippo, S. Passe, 2021, Clinical and translational science.

Retinoids for the future: investigational approaches for the identification of new compounds.

R. Armstrong, J. Grippo, A. Levin, 1992, Journal of the American Academy of Dermatology.

CHAPTER 12 – Inactivation, Activation, and Stabilization of Glucocorticoid Receptors

J. Grippo, W. Pratt, M. Dahmer, 1984 .

Phosphorylation of the glucocorticoid receptor

J. Grippo, W. Pratt, M. Dahmer, 1984 .

The effect of dibutyryl cyclic AMP and butyrate on F9 teratocarcinoma cellular retinoic acid-binding protein activity.

J. Grippo, L. Gudas, 1987, The Journal of biological chemistry.

Expression of nuclear retinoic acid receptors in wild-type and mutant embryonal carcinoma PCC4.aza1R cells.

George, J. Grippo, K. Shudo, 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids.

P Chambon, P. Chambon, P. Kastner, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Improved human bioavailability of vemurafenib, a practically insoluble drug, using an amorphous polymer-stabilized solid dispersion prepared by a solvent-controlled coprecipitation process.

J. Grippo, P. Ibrahim, D. Choi, 2013, Journal of pharmaceutical sciences.

New retinoid X receptor subtypes in zebra fish (Danio rerio) differentially modulate transcription and do not bind 9-cis retinoic acid

M. Boffa, J. Grippo, A. Levin, 1995, Molecular and cellular biology.

Analysis of dermatologic events in vemurafenib-treated patients with melanoma.

A. Hauschild, D. Schadendorf, M. Lacouture, 2013, The oncologist.

A phase I study of R547, a novel, selective inhibitor of cell cycle and transcriptional cyclin dependent kinases (CDKs)

A. Tan, S. Eckhardt, J. Grippo, 2007 .

Retinoid-binding proteins in embryonal carcinoma cells.

J. Grippo, M. Sherman, 1990, Methods in enzymology.

The AF-2 Region of the Retinoic Acid Receptor α Mediates Retinoic Acid Inhibition of Estrogen Receptor Function in Breast Cancer Cells*

D. Novosad, M. Pratt, J. Grippo, 1996, The Journal of Biological Chemistry.

Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy

J. Grippo, M. Magnuson, F. Matschinsky, 2003, Science.

The mouse Dlx-2 (Tes-1) gene is expressed in spatially restricted domains of the forebrain, face and limbs in midgestation mouse embryos

J. Rubenstein, L. Puelles, M. Porteus, 1993, Mechanisms of Development.

Identification and characterization of nuclear retinoic acid-binding activity in human myeloblastic leukemia HL-60 cells.

J. Grippo, C. Nervi, A. Jetten, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Phase I study of PLX4032: Proof of concept for V600E BRAF mutation as a therapeutic target in human cancer.

K. Flaherty, J. Sosman, R. J. Lee, 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

A single-dose mass balance and metabolite-profiling study of vemurafenib in patients with metastatic melanoma

R. Dummer, A. Joe, J. Grippo, 2015, Pharmacology research & perspectives.

A phase I, randomized, open-label study of the multiple-dose pharmacokinetics of vemurafenib in patients with BRAFV600E mutation-positive metastatic melanoma

A. Joe, P. Munster, A. Daud, 2013, Cancer Chemotherapy and Pharmacology.

6BA Early efficacy signal demonstrated in advanced melanoma in a phase I trial of the oncogenic BRAF-selective inhibitor PLX4032

K. Flaherty, J. Sosman, A. Ribas, 2009 .

Two nuclear signalling pathways for vitamin D

C. Carlberg, J. Grippo, I. Bendik, 1993, Nature.

Nuclear Import of Hepatic Glucokinase Depends upon Glucokinase Regulatory Protein, whereas Export Is Due to a Nuclear Export Signal Sequence in Glucokinase*

J. Grippo, M. Magnuson, Chiyo Shiota, 1999, The Journal of Biological Chemistry.

Evidence that the endogenous heat-stable glucocorticoid receptor-activating factor is thioredoxin.

J. Grippo, W. Pratt, M. Dahmer, 1983, The Journal of biological chemistry.

Murine glucocorticoid receptors and the H-2 locus--a reappraisal.

J. Grippo, R. Erickson, W. Pratt, 1984, Journal of steroid biochemistry.

Clinical Study of Single‐Stranded Oligonucleotide RO7062931 in Healthy Volunteers and Patients With Chronic Hepatitis B

M. Yuen, D. J. Kim, J. Grippo, 2021, Hepatology.

A Single and Multiple Ascending Dose Study of Toll‐Like Receptor 7 Agonist (RO7020531) in Chinese Healthy Volunteers

T. Racek, J. Grippo, Yonghong Zhu, 2020, Clinical and translational science.

Ectopic Hoxa-1 induces rhombomere transformation in mouse hindbrain.

R. Krumlauf, J. Grippo, T. Gridley, 1994, Development.

Retinoic acid receptor belongs to a subclass of nuclear receptors that do not form "docking" complexes with hsp90.

P. Chambon, J. Grippo, W. Pratt, 1991, Biochemistry.

The role of sulfhydryl groups in permitting transformation and DNA binding of the glucocorticoid receptor.

S. Meshinchi, A. Holmgren, J. Grippo, 1987, The Journal of biological chemistry.

A New Pathway for Vitamin A

C. Kratzeisen, J. Grippo, A. Lovey, 1992 .

A systematic analysis of the AF‐2 domain of human retinoic acid receptor α reveals amino acids critical for transcriptional activation and conformational integrity

J. Grippo, A. Levin, G. Allenby, 1996, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Isolation and binding characteristics of nuclear retinoic acid receptors.

J. Grippo, C. Nervi, A. Jetten, 1990, Methods in enzymology.

Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats.

J. Grippo, M. Magnuson, C. Chu, 2004, American journal of physiology. Gastrointestinal and liver physiology.

Cancer Therapy : Clinical Pharmacokinetically Guided Phase 1 Trial of the IGF-1 Receptor Antagonist RG 1507 in Children with Recurrent or Refractory Solid Tumors

J. Grippo, C. Herzog, F. Balis, 2011 .

Glucokinase gene locus transgenic mice are resistant to the development of obesity-induced type 2 diabetes.

J. Grippo, M. Magnuson, A. Cherrington, 2001, Diabetes.

Characterization of the ligand binding domain of human retinoid X receptor alpha expressed in Escherichia coli.

J. Grippo, A. Norris, M. Rosenberger, 1994, The Journal of biological chemistry.

Mutagenesis of the Ligand Binding Domain of the Human Retinoic Acid Receptor α Identifies Critical Residues for 9-cis-Retinoic Acid Binding (*)

J. Grippo, B. Tate, 1995, The Journal of Biological Chemistry.

RO7062931 antisense oligonucleotide phase 1 study demonstrates target engagement in patients with chronic hepatitis B on established nucleos(t)ide therapy

M. Yuen, D. J. Kim, J. Grippo, 2020, Journal of Hepatology.

Biochemical and Retinoid Receptor Activities in Human Sebaceous Cells

J. Grippo, A. Levin, E. Pacia, 1991 .

Characteristics of an endogenous glucocorticoid receptor stabilizing factor.

J. Grippo, K. Leach, W. Pratt, 1982, Journal of Biological Chemistry.

The discovery of 9-cis retinoic acid a hormone that binds the retinoid-X receptor

J. Grippo, A. Levin, B. Tate, 1994, Trends in Endocrinology & Metabolism.

Erratum: Inhibition of estrogen-responsive gene activation by the retinoid X receptor β: Evidence for multiple inhibitory pathways (Molecular and Cellular Biology 13:4 (2258))

S. Hirschfeld, K. Ozato, M. Marks, 1993 .

PLX4032, a highly selective V600EBRAF kinase inhibitor: Clinical correlation of activity with pharmacokinetic and pharmacodynamic parameters in a phase I trial.

K. Flaherty, J. Sosman, A. Ribas, 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The effects of a high‐fat meal on single‐dose vemurafenib pharmacokinetics

A. Ribas, A. Joe, G. Daniels, 2014, Journal of clinical pharmacology.

Characterization of the chimeric retinoic acid receptor RARalpha/VDR.

K. Ozato, P. Abarzúa, S. Pemrick, 1998, Leukemia.

The melanocortin receptor MCR4 controls fat consumption

J. Grippo, P. Samama, Leonid Rumennik, 2003, Regulatory Peptides.