Z. Ruan

发表

Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization

P. Eyers, N. Kannan, S. Mohanty, 2016, PLoS genetics.

Correction: Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization

P. Eyers, N. Kannan, S. Mohanty, 2016, PLoS genetics.

The Hippo Pathway Maintains the Equatorial Division Plane in the Ciliate Tetrahymena

N. Kannan, Z. Ruan, J. Frankel, 2017, Genetics.

LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena

N. Kannan, Z. Ruan, E. Orias, 2019, bioRxiv.

Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources

Cathy H. Wu, Cecilia Arighi, Liang-Chin Huang, 2018, Scientific Reports.

Extensive non-canonical phosphorylation in human cells revealed using strong-anion exchange-mediated phosphoproteomics

Andrew R. Jones, P. Eyers, N. Kannan, 2017, bioRxiv.

Two Antagonistic Hippo Signaling Circuits Set the Division Plane at the Medial Position in the Ciliate Tetrahymena

N. Kannan, Z. Ruan, J. Frankel, 2018, Genetics.

Mechanistic Insights into R776H Mediated Activation of Epidermal Growth Factor Receptor Kinase.

N. Kannan, Z. Ruan, 2015, Biochemistry.

Computational and Experimental Characterization of Patient Derived Mutations Reveal an Unusual Mode of Regulatory Spine Assembly and Drug Sensitivity in EGFR Kinase.

N. Kannan, Z. Ruan, S. Katiyar, 2017, Biochemistry.

Substrate binding allosterically relieves autoinhibition of the TRIB1 pseudokinase

N. Kannan, A. Axtman, Z. Ruan, 2018, bioRxiv.

Structures and pH sensing mechanism of proton-activated chloride channel

Z. Ruan, Juan Du, Wei Lü, 2020, Nature.

Inhibition of the proton-activated chloride channel PAC by PIP2

Z. Ruan, Wei Lü, James Osei-Owusu, 2022, bioRxiv.

57 Activation mechanism of R776H mutation in Epidermal Growth Factor Receptor (EGFR)

N. Kannan, Z. Ruan, 2015, Journal of biomolecular structure & dynamics.

Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC

Z. Ruan, Wei Lü, Daniel S. Matasic, 2022, bioRxiv.

Molecular determinants of pH sensing in the proton-activated chloride channel

H. Weinstein, Z. Ruan, Wei Lü, 2022, Proceedings of the National Academy of Sciences of the United States of America.

STRAW: Species TRee Analysis Web server

Liang Liu, Timothy I. Shaw, Zheng Ruan, 2013, Nucleic Acids Res..

Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1

N. Kannan, A. Axtman, Z. Ruan, 2018, Science Signaling.

Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.

Nicholas W. Kwiecien, Paul D Hutchins, M. Westphall, 2016, Molecular cell.

Emerging roles of the αC‐β4 loop in protein kinase structure, function, evolution, and disease

Wayland Yeung, Zheng Ruan, Natarajan Kannan, 2020, IUBMB life.

Altered conformational landscape and dimerization dependency underpins the activation of EGFR by αC–β4 loop insertion mutations

Zheng Ruan, Natarajan Kannan, N. Kannan, 2018, Proceedings of the National Academy of Sciences.

Zebrafish as a New Platform Used in Exploration of Ketamine-Induced Neurodevelopmental Toxicity

Wei Zhou, Z. Ruan, Bo Xu, 2015 .

Identification of a novel strain of influenza A (H9N2) virus in chicken

Z. Ruan, Ning Wang, Xingyi Ge, 2015, Virologica Sinica.

Co-Conserved MAPK Features Couple D-Domain Docking Groove to Distal Allosteric Sites via the C-Terminal Flanking Tail

T. Nguyen, N. Kannan, Krishnadev Oruganty, 2015, PloS one.

Coupled regulation by the juxtamembrane and sterile α motif (SAM) linker is a hallmark of ephrin tyrosine kinase evolution

N. Kannan, Annie Kwon, Z. Ruan, 2018, The Journal of Biological Chemistry.

Structures of human pannexin 1 reveal ion pathways and mechanism of gating

Z. Ruan, Juan Du, Wei Lü, 2020, Nature.

Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition

Z. Ruan, Juan Du, Wei Lü, 2021, Nature structural & molecular biology.

Structures of TRPM5 channel elucidate mechanism of activation and inhibition

Z. Ruan, Juan Du, Wei Lü, 2021, bioRxiv.

Endosomes and Microtubles are Required for Productive Infection in Aquareovirus

Z. Ruan, Q. Fang, Fuxian Zhang, 2019, Virologica Sinica.

Hematopoietic gene expression profile in zebrafish kidney marrow.

L. Zon, A. Look, Zhu Chen, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition

Z. Ruan, Juan Du, Wei Lü, 2021, Nature Structural & Molecular Biology.

LF4/MOK and a CDK-related kinase regulate the number and length of cilia in Tetrahymena

N. Kannan, Z. Ruan, E. Orias, 2019, bioRxiv.

Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis

Yamuna Krishnan, Z. Ruan, Junhua Yang, 2021, Cell reports.

Endosomes and Microtubles are Required for Productive Infection in Aquareovirus

Z. Ruan, Q. Fang, Fuxian Zhang, 2019, Virologica Sinica.

Zebrafish models of heart development and cardiovascular diseases

Z. Ruan, W. Zhou, Bo Xu, 2015 .

Palladin is a novel microtubule-associated protein responsible for spindle orientation

Saijuan Chen, Zhu Chen, Z. Ruan, 2017, Scientific Reports.

Palladin is a novel microtubule-associated protein responsible for spindle orientation

Saijuan Chen, Zhu Chen, Z. Ruan, 2017, Scientific Reports.

Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization

P. Eyers, N. Kannan, S. Mohanty, 2016, PLoS genetics.

Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation.

Aaron M. Beedle, N. Kannan, Z. Ruan, 2017, Bioorganic & medicinal chemistry.

Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.

Nicholas W. Kwiecien, Paul D Hutchins, M. Westphall, 2016, Molecular cell.