S. Joshi

发表

Excipients differentially influence the conformational stability and pretransition dynamics of two IgG1 monoclonal antibodies.

C Russell Middaugh, Sangeeta B Joshi, David B Volkin, 2012, Journal of pharmaceutical sciences.

Spectroscopic methods for the physical characterization and formulation of nonviral gene delivery systems.

S. Joshi, C. R. Middaugh, S. Ausar, 2008, Methods in molecular biology.

Protein-excipient interactions: mechanisms and biophysical characterization applied to protein formulation development.

Tim J Kamerzell, C Russell Middaugh, Sangeeta B Joshi, 2011, Advanced drug delivery reviews.

Vaccine instability in the cold chain: mechanisms, analysis and formulation strategies.

S. Joshi, D. Volkin, C. R. Middaugh, 2014, Biologicals : journal of the International Association of Biological Standardization.

The interaction of heparin/polyanions with bovine, porcine, and human growth hormone.

S. Joshi, C. R. Middaugh, Tim J. Kamerzell, 2008, Journal of pharmaceutical sciences.

Physical Characterization and Stabilization of a Lentiviral Vector Against Adsorption and Freeze-Thaw.

S. Joshi, D. Volkin, Ozan S. Kumru, 2018, Journal of pharmaceutical sciences.

H1N1 influenza virus-like particles: physical degradation pathways and identification of stabilizers.

S. Joshi, C. R. Middaugh, Leslie Dokken, 2011, Journal of pharmaceutical sciences.

High-throughput biophysical analysis and data visualization of conformational stability of an IgG1 monoclonal antibody after deglycosylation.

C Russell Middaugh, David D Weis, Sangeeta B Joshi, 2013, Journal of pharmaceutical sciences.

Holistic process development to mitigate proteolysis of a subunit rotavirus vaccine candidate produced in Pichia pastoris by means of an acid pH pulse during fed‐batch fermentation

K. Kaur, S. Joshi, D. Volkin, 2020, Biotechnology progress.

A modular protein subunit vaccine candidate produced in yeast confers protection against SARS-CoV-2 in non-human primates

Neil C. Dalvie, J. C. Love, Sergio A. Rodriguez-Aponte, 2021, bioRxiv.

Effect of Aluminum Adjuvant and Preservatives on Structural Integrity and Physicochemical Stability Profiles of Three Recombinant Subunit Rotavirus Vaccine Antigens

S. Joshi, D. Volkin, R. Sitrin, 2020, Journal of pharmaceutical sciences.

Site-Specific Hydrolysis Reaction C-Terminal of Methionine in Met-His during Metal-Catalyzed Oxidation of IgG-1.

S. Joshi, D. Volkin, C. Schöneich, 2016, Molecular pharmaceutics.

Investigation of a monoclonal antibody against enterotoxigenic Escherichia coli, expressed as secretory IgA1 and IgA2 in plants

M. Klempner, L. Cavacini, R. Guerrant, 2021, Gut microbes.

Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice.

J. Karanicolas, D. Jacobs, S. Joshi, 2016, Journal of pharmaceutical sciences.

Effect of single-point mutations on the stability and immunogenicity of a recombinant ricin A chain subunit vaccine antigen

J. Karanicolas, S. Joshi, D. Volkin, 2013, Human vaccines & immunotherapeutics.

Coformulation of Broadly Neutralizing Antibodies 3BNC117 and PGT121: Analytical Challenges During Preformulation Characterization and Storage Stability Studies

S. Joshi, D. Volkin, B. Kerwin, 2018, Journal of pharmaceutical sciences.

Characterization of Excipient Effects on Reversible Self-association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 1.

S. Joshi, D. Volkin, C. R. Middaugh, 2019, Journal of pharmaceutical sciences.

High-Definition Mapping of Four Spatially Distinct Neutralizing Epitope Clusters on RiVax, a Candidate Ricin Toxin Subunit Vaccine

S. Joshi, D. Volkin, C. R. Middaugh, 2017, Clinical and Vaccine Immunology.

An empirical phase diagram approach to investigate conformational stability of “second‐generation” functional mutants of acidic fibroblast growth factor‐1

Jihun Lee, M. Blaber, S. Joshi, 2012, Protein science : a publication of the Protein Society.

Spectroscopy of Vaccines

S. Joshi, C. Middaugh, 2011 .

Impact of Glycosylation on the Local Backbone Flexibility of Well-Defined IgG1-Fc Glycoforms Using Hydrogen Exchange-Mass Spectrometry.

S. Joshi, D. Volkin, D. Weis, 2018, Journal of pharmaceutical sciences.

The effects of substituted cyclodextrins on the colloidal and conformational stability of selected proteins.

S. Joshi, A. Bhambhani, Feng He, 2010, Journal of pharmaceutical sciences.

High throughput prediction of the long-term stability of pharmaceutical macromolecules from short-term multi-instrument spectroscopic data.

Vidyashankara G. Iyer, G. Winter, S. Joshi, 2014, Journal of pharmaceutical sciences.

Development of Stabilizing Formulations of a Trivalent Inactivated Poliovirus Vaccine in a Dried State for Delivery in the Nanopatch™ Microprojection Array

S. Joshi, D. Volkin, J. Hickey, 2018, Journal of pharmaceutical sciences.

Investigation of protein conformational stability employing a multimodal spectrometer.

S. Joshi, D. Volkin, Lei Hu, 2011, Analytical chemistry.

Challenges and opportunities of using liquid chromatography and mass spectrometry methods to develop complex vaccine antigens as pharmaceutical dosage forms.

S. Joshi, D. Volkin, J. Hickey, 2016, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Physical characterization of clostridium difficile toxins and toxoids: effect of the formaldehyde crosslinking on thermal stability.

Maya S. Salnikova, S. Joshi, J. H. Rytting, 2008, Journal of pharmaceutical sciences.

Biophysical characterization and conformational stability of Ebola and Marburg virus-like particles.

S. Joshi, D. Volkin, J. Trefethen, 2011, Journal of pharmaceutical sciences.

Antigen-adjuvant interactions, stability, and immunogenicity profiles of a SARS-CoV-2 receptor-binding domain (RBD) antigen formulated with aluminum salt and CpG adjuvants

Neil C. Dalvie, J. C. Love, K. Kaur, 2022, Human vaccines & immunotherapeutics.

Analytical Comparability Assessments of 5 Recombinant CRM197 Proteins From Different Manufacturers and Expression Systems.

K. Kaur, S. Joshi, D. Volkin, 2018, Journal of pharmaceutical sciences.

Understanding the relevance of local conformational stability and dynamics to the aggregation propensity of an IgG1 and IgG2 monoclonal antibodies

Santosh V. Thakkar, S. Joshi, D. Volkin, 2013, Protein science : a publication of the Protein Society.

Prophylactic Activity of Orally Administered FliD-Reactive Monoclonal SIgA Against Campylobacter Infection

S. Joshi, D. Volkin, F. Seehusen, 2020, Frontiers in Immunology.

Physical characterization and formulation development of a recombinant pneumolysoid protein-based pneumococcal vaccine.

S. Joshi, D. Volkin, Lei Hu, 2013, Journal of pharmaceutical sciences.

Biophysical characterization and immunization studies of dominant negative inhibitor (DNI), a candidate anthrax toxin subunit vaccine

Vidyashankara G. Iyer, S. Joshi, D. Volkin, 2013, Human vaccines & immunotherapeutics.

Anthrax vaccine powder formulations for nasal mucosal delivery.

Vincent J. Sullivan, L. Peek, S. Joshi, 2006, Journal of pharmaceutical sciences.

Linking the solution viscosity of an IgG2 monoclonal antibody to its structure as a function of pH and temperature.

C Russell Middaugh, Sangeeta B Joshi, David B Volkin, 2013, Journal of pharmaceutical sciences.

Molecular engineering of a cryptic epitope in Spike RBD improves manufacturability and neutralizing breadth against SARS-CoV-2 variants

Neil C. Dalvie, J. C. Love, Sergio A. Rodriguez-Aponte, 2022, bioRxiv.

Analytical and Preformulation Characterization Studies of Human Papillomavirus Virus-Like Particles to Enable Quadrivalent Multi-Dose Vaccine Formulation Development.

S. Joshi, D. Volkin, S. Brendle, 2022, Journal of pharmaceutical sciences.

Analytical characterization and formulation assessment of model secretory- immunoglobulin-A (sIgAs) for their potential use as low cost, orally delivered sIgAs

M. Klempner, L. Cavacini, S. Joshi, 2018 .

Biophysical and formulation studies of the Schistosoma mansoni TSP-2 extracellular domain recombinant protein, a lead vaccine candidate antigen for intestinal schistosomiasis

P. Hotez, S. Joshi, D. Volkin, 2013, Human vaccines & immunotherapeutics.

Effect of 2 Emulsion-Based Adjuvants on the Structure and Thermal Stability of Staphylococcus aureus Alpha-Toxin.

Vidyashankara G. Iyer, S. Joshi, D. Volkin, 2018, Journal of pharmaceutical sciences.

Effect of Two Emulsion-Based Adjuvants on the Structure and Thermal Stability of S. aureus Alpha-toxin

Vidyashankara G. Iyer, S. Joshi, D. Volkin, 2018 .

Effect of acrylodan conjugation and forced oxidation on the structural integrity, conformational stability, and binding activity of a glucose binding protein SM4 used in a prototype continuous glucose monitor

A. Metters, S. Joshi, D. Volkin, 2017, Protein science : a publication of the Protein Society.

A systematic approach to stabilizing EBA-175 RII-NG for use as a malaria vaccine.

L. Peek, S. Joshi, L. Jones, 2006, Vaccine.

Combined semi-empirical screening and design of experiments (DOE) approach to identify candidate formulations of a lyophilized live attenuated tetravalent viral vaccine candidate.

Jill A. Livengood, S. Joshi, D. Volkin, 2017, Vaccine.

Parathyroid hormone is a heparin/polyanion binding protein: Binding energetics and structure modification

S. Joshi, Tim J. Kamerzell, K. Toney, 2007, Protein science : a publication of the Protein Society.

Preformulation studies of Clostridium difficile toxoids A and B.

Maya S. Salnikova, S. Joshi, J. H. Rytting, 2008, Journal of pharmaceutical sciences.

Formulation and immunogenicity of a potential multivalent type III secretion system-based protein vaccine.

S. Joshi, W. Picking, R. Esfandiary, 2010, Journal of pharmaceutical sciences.

SARS-CoV-2 receptor binding domain displayed on HBsAg virus–like particles elicits protective immunity in macaques

Neil C. Dalvie, J. C. Love, Sergio A. Rodriguez-Aponte, 2022, Science advances.

Parenteral immunization with IpaB/IpaD protects mice against lethal pulmonary infection by Shigella.

S. Joshi, W. Picking, Shyamal P. Choudhari, 2013, Vaccine.

Current and next-generation formulation strategies for inactivated polio vaccines to lower costs, increase coverage, and facilitate polio eradication

S. Joshi, D. Volkin, Christopher Bird, 2022, Human vaccines & immunotherapeutics.

Compatibility, physical stability, and characterization of an IgG4 monoclonal antibody after dilution into different intravenous administration bags.

C Russell Middaugh, Sangeeta B Joshi, David B Volkin, 2012, Journal of pharmaceutical sciences.

A Micro-Polyethylene Glycol Precipitation Assay as a Relative Solubility Screening Tool for Monoclonal Antibody Design and Formulation Development.

S. Joshi, D. Volkin, R. Schwartz, 2016, Journal of pharmaceutical sciences.

Characterization of Excipient Effects on Reversible Self-association, Backbone Flexibility, and Solution Properties of an IgG1 Monoclonal Antibody at High Concentrations: Part 2.

S. Joshi, D. Volkin, R. Esfandiary, 2019, Journal of pharmaceutical sciences.

Empirical Correction for Differences in Chemical Exchange Rates in Hydrogen Exchange-Mass Spectrometry Measurements.

Brittney J. Mills, S. Joshi, S. Bishop, 2017, Analytical chemistry.

Probing protein structure and dynamics by second‐derivative ultraviolet absorption analysis of cation–π interactions

L. Peek, S. Joshi, L. Kueltzo, 2006, Protein science : a publication of the Protein Society.

A Formulation Development Approach to Identify and Select Stable Ultra-High-Concentration Monoclonal Antibody Formulations With Reduced Viscosities.

C Russell Middaugh, Sangeeta B Joshi, David B Volkin, 2017, Journal of pharmaceutical sciences.

Charge-mediated Fab-Fc interactions in an IgG1 antibody induce reversible self-association, cluster formation, and elevated viscosity

C. Russell Middaugh, David B. Volkin, Steven M. Bishop, 2016, mAbs.

Oligomeric states of the Shigella translocator protein IpaB provide structural insights into formation of the type III secretion translocon

S. Joshi, W. Picking, N. Dickenson, 2013, Protein science : a publication of the Protein Society.

The Botanical Drug Substance Crofelemer as a Model System for Comparative Characterization of Complex Mixture Drugs.

Eric J. Deeds, Peter A Kleindl, Maulik K. Nariya, 2017, Journal of pharmaceutical sciences.

Local dynamics and their alteration by excipients modulate the global conformational stability of an lgG1 monoclonal antibody.

Santosh V. Thakkar, S. Joshi, H. Sathish, 2012, Journal of pharmaceutical sciences.

Multi-dose Formulation Development for a Quadrivalent Human Papillomavirus Virus-Like Particle-Based Vaccine: Part II- Real-time and Accelerated Stability Studies.

S. Joshi, D. Volkin, S. Brendle, 2022, Journal of pharmaceutical sciences.

Interaction of aluminum-adjuvanted recombinant P[4] protein antigen with preservatives: Storage stability and backbone flexibility studies.

S. Joshi, D. Volkin, D. Weis, 2021, Journal of pharmaceutical sciences.

Short-term and longer-term protective immune responses generated by subunit vaccination with smallpox A33, B5, L1 or A27 proteins adjuvanted with aluminum hydroxide and CpG in mice challenged with vaccinia virus

S. Joshi, D. Volkin, G. Buchman, 2020, Vaccine.

Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid A adjuvants.

Theodore W Randolph, C Russell Middaugh, Lilia A. Rabia, 2015, Journal of pharmaceutical sciences.

Preformulation characterization of an aluminum salt-adjuvanted trivalent recombinant protein-based vaccine candidate against Streptococcus pneumoniae.

C Russell Middaugh, Vidyashankara G. Iyer, Sangeeta B Joshi, 2012, Journal of pharmaceutical sciences.

Multidimensional methods for the formulation of biopharmaceuticals and vaccines.

S. Joshi, D. Volkin, J. Ralston, 2011, Journal of pharmaceutical sciences.

Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice

Laura E. Crowell, Neil C. Dalvie, J. C. Love, 2021, Proceedings of the National Academy of Sciences.

Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters

Laura E. Crowell, Neil C. Dalvie, J. C. Love, 2021, bioRxiv.

Adsorption of recombinant poxvirus L1-protein to aluminum hydroxide/CpG vaccine adjuvants enhances immune responses and protection of mice from vaccinia virus challenge.

S. Joshi, D. Volkin, G. Buchman, 2013, Vaccine.

Comparison of high-throughput biophysical methods to identify stabilizing excipients for a model IgG2 monoclonal antibody: conformational stability and kinetic aggregation measurements.

C Russell Middaugh, Sangeeta B Joshi, David B Volkin, 2012, Journal of pharmaceutical sciences.

A C-terminal Pfs48/45 malaria transmission-blocking vaccine candidate produced in the baculovirus expression system

S. Joshi, D. Volkin, C. King, 2020, Scientific Reports.

The Pfs230 N-terminal fragment, Pfs230D1+: expression and characterization of a potential malaria transmission-blocking vaccine candidate

S. Joshi, D. Volkin, J. Hickey, 2019, Malaria Journal.

Production, Characterization, and Biological Evaluation of Well-Defined IgG1 Fc Glycoforms as a Model System for Biosimilarity Analysis.

Ishan S. Shah, S. Joshi, D. Volkin, 2016, Journal of pharmaceutical sciences.

Formulation development of a live attenuated human rotavirus (RV3-BB) vaccine candidate for use in low- and middle-income countries

S. Joshi, D. Volkin, J. Bines, 2021, Human vaccines & immunotherapeutics.

Using spectroscopic and microscopic methods to probe the structural stability of human adenovirus type 4

S. Joshi, V. Truong-Le, H. Shinogle, 2010, Human vaccines.

Chapter 7: An Empirical Phase Diagram: High-Throughput Screening Approach to the Characterization and Formulation of Biopharmaceuticals

Eric J. Deeds, S. Joshi, A. Bhambhani, 2020, Development of Biopharmaceutical Drug-Device Products.

Characterization of an oncolytic herpes simplex virus drug candidate.

S. Joshi, D. Volkin, B. Kerwin, 2015, Journal of pharmaceutical sciences.

The Physical Analysis of Vaccines

S. Joshi, D. Volkin, Justin C. Thomas, 2015 .

High Throughput Screening for Stabilizers of Vaccine Antigens

S. Joshi, D. Volkin, C. Middaugh, 2013 .

An Empirical Phase Diagram–High‐Throughput Screening Approach to the Characterization and Formulation of Biopharmaceuticals

C. Russell Middaugh, Sangeeta B. Joshi, S. Joshi, 2010 .

Stabilization of measles virus for vaccine formulation

C. Russell Middaugh, Sangeeta B. Joshi, Salvador F. Ausar, 2008, Human vaccines.

Formulation design and high-throughput excipient selection based on structural integrity and conformational stability of dilute and highly concentrated IgG1 monoclonal antibody solutions.

C Russell Middaugh, Sangeeta B Joshi, David B Volkin, 2012, Journal of pharmaceutical sciences.

Biophysical characterization and stabilization of the recombinant albumin fusion protein sEphB4-HSA.

C Russell Middaugh, Sangeeta B Joshi, David B Volkin, 2012, Journal of pharmaceutical sciences.

Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus

Alexandra Bonnyman, John M. Hickey, David B. Volkin, 2020, bioRxiv.

Formulation and stabilization of recombinant protein based virus-like particle vaccines.

S. Joshi, D. Volkin, C. Russell Middaugh, 2015, Advanced drug delivery reviews.

An application of ultraviolet spectroscopy to study interactions in proteins solutions at high concentrations.

Santosh V. Thakkar, S. Joshi, D. Volkin, 2012, Journal of pharmaceutical sciences.

Measurement of Adenovirus-Based Vector Heterogeneity

Shaleem I Jacob, S. Joshi, D. Volkin, 2022, Journal of pharmaceutical sciences.

Effect of ionic strength and pH on the physical and chemical stability of a monoclonal antibody antigen-binding fragment.

C Russell Middaugh, Sangeeta B Joshi, David B Volkin, 2013, Journal of pharmaceutical sciences.

Structural stability of hepatitis C virus envelope glycoprotein E1: effect of pH and dissociative detergents.

S. Joshi, F. Bosman, Feng He, 2009, Journal of pharmaceutical sciences.

Identifying stabilizers of plasmid DNA for pharmaceutical use.

S. Joshi, D. Volkin, J. Ramsey, 2011, Journal of pharmaceutical sciences.

Membrane Fusion Promoted by Increasing Surface Densities of the Paramyxovirus F and HN Proteins: Comparison of Fusion Reactions Mediated by Simian Virus 5 F, Human Parainfluenza Virus Type 3 F, and Influenza Virus HA

R. Lamb, S. Joshi, R. Dutch, 1998, Journal of Virology.

Properties of synthetic spider silk fibers based on Argiope aurantia MaSp2.

C Russell Middaugh, Amanda E Brooks, Randolph V Lewis, 2008, Biomacromolecules.

Modeling the long-term 2-8 °C stability profiles of a live, rotavirus vaccine candidate (RV3-BB) in various liquid formulations via extrapolations of real-time and accelerated stability data

S. Joshi, D. Volkin, J. Bines, 2021, Biologicals (Print).

Effect of Formulation Variables on the Stability of a Live, Rotavirus (RV3-BB) Vaccine Candidate using in vitro Gastric Digestion Models to Mimic Oral Delivery

S. Joshi, D. Volkin, J. Bines, 2020, Journal of pharmaceutical sciences.

Characterizing and Minimizing Aggregation and Particle Formation of Three Recombinant Fusion-Protein Bulk Antigens for Use in a Candidate Trivalent Rotavirus Vaccine

S. Joshi, D. Volkin, R. Sitrin, 2020, Journal of pharmaceutical sciences.

Correlating physicochemical and biological properties to define critical quality attributes of a recombinant AAV vaccine candidate

S. Joshi, D. Volkin, L. Vandenberghe, 2023, bioRxiv.

Preformulation Characterization and Stability Assessments of Secretory IgA Monoclonal Antibodies as Potential Candidates for Passive Immunization by Oral Administration

M. Klempner, L. Cavacini, S. Joshi, 2020, Journal of pharmaceutical sciences.

Developing a manufacturing process to deliver a cost effective and stable liquid human rotavirus vaccine

S. Joshi, D. Volkin, J. Bines, 2021, Vaccine.

Recombinant Subunit Rotavirus Trivalent Vaccine Candidate: Physicochemical Comparisons and Stability Evaluations of Three Protein Antigens

S. Joshi, D. Volkin, R. Sitrin, 2019, Journal of pharmaceutical sciences.

Concordance of in vitro and in vivo measures of non-replicating rotavirus vaccine potency

S. Joshi, D. Volkin, R. Sitrin, 2022, Vaccine.

Crystallization of a nonreplicating rotavirus vaccine candidate

Moo Sun Hong, R. Braatz, K. Kaur, 2021, Biotechnology and Bioengineering.

Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens

Shaleem I Jacob, Neil C. Dalvie, J. C. Love, 2020, Journal of pharmaceutical sciences.

Mechanism of Thimerosal-Induced Structural Destabilization of a Recombinant Rotavirus P[4] Protein Antigen Formulated as a Multi-Dose Vaccine

Neil C. Dalvie, J. C. Love, Joseph R. Brady, 2020, Journal of pharmaceutical sciences.

Development of a candidate stabilizing formulation for bulk storage of a double mutant heat labile toxin (dmLT) protein based adjuvant

S. Joshi, D. Volkin, J. Hickey, 2017, Vaccine.

Structural characterization of IgG1 mAb aggregates and particles generated under various stress conditions.

C Russell Middaugh, Sangeeta B Joshi, David B Volkin, 2014, Journal of pharmaceutical sciences.

Development of a stable virus-like particle vaccine formulation against Chikungunya virus and investigation of the effects of polyanions.

C Russell Middaugh, Sangeeta B Joshi, David B Volkin, 2013, Journal of pharmaceutical sciences.

Correlating the Impact of Well-Defined Oligosaccharide Structures on Physical Stability Profiles of IgG1-Fc Glycoforms.

S. Joshi, D. Volkin, J. H. Kim, 2016, Journal of pharmaceutical sciences.

Physical stability comparisons of IgG1-Fc variants: effects of N-glycosylation site occupancy and Asp/Gln residues at site Asn 297.

S. Joshi, D. Volkin, J. H. Kim, 2014, Journal of pharmaceutical sciences.

Correlating the Effects of Antimicrobial Preservatives on Conformational Stability, Aggregation Propensity, and Backbone Flexibility of an IgG1 mAb.

S. Joshi, D. Volkin, D. Weis, 2017, Journal of pharmaceutical sciences.

Measurement of Adenovirus-Based Vector Heterogeneity

Shaleem I Jacob, S. Joshi, D. Volkin, 2022, Journal of pharmaceutical sciences.

A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

B. Pulendran, M. Feinberg, S. Joshi, 2022, bioRxiv.

Formulation development and comparability studies with an aluminum-salt adjuvanted SARS-CoV-2 Spike ferritin nanoparticle vaccine antigen produced from two different cell lines

S. Joshi, D. Volkin, Ozan S. Kumru, 2023, bioRxiv.

Developability Assessment of Physicochemical Properties and Stability Profiles of HIV-1 BG505 SOSIP.664 and BG505 SOSIP.v4.1-GT1.1 gp140 Envelope Glycoprotein Trimers as Candidate Vaccine Antigens

John P. Moore, A. Ward, A. Cupo, 2019, Journal of pharmaceutical sciences.

Characterization and stabilization of recombinant human protein pentraxin (rhPTX-2).

C Russell Middaugh, Sangeeta B Joshi, David B Volkin, 2013, Journal of pharmaceutical sciences.

Probing structurally altered and aggregated states of therapeutically relevant proteins using GroEL coupled to bio‐layer interferometry

S. Joshi, D. Volkin, Ozan S. Kumru, 2014, Protein science : a publication of the Protein Society.

Towards development of stable formulations of a live attenuated bacterial vaccine: A preformulation study facilitated by a biophysical approach

S. Joshi, Haihong Fan, Russell A Martin, 2009, Human vaccines.

Comparison of the structural stability and dynamic properties of recombinant anthrax protective antigen and its 2-fluorohistidine-labeled analogue.

Santosh V. Thakkar, S. Joshi, D. Volkin, 2012, Journal of pharmaceutical sciences.

Preformulation Characterization, Stabilization, and Formulation Design for the Acrylodan-Labeled Glucose-Binding Protein SM4-AC.

A. Metters, S. Joshi, D. Volkin, 2017, Journal of pharmaceutical sciences.

Case Studies Applying Biophysical Techniques to Better Characterize Protein Aggregates and Particulates of Varying Size

S. Joshi, D. Volkin, Ozan S. Kumru, 2013 .

Using empirical phase diagrams to understand the role of intramolecular dynamics in immunoglobulin G stability.

Tim J Kamerzell, C Russell Middaugh, Sangeeta B Joshi, 2009, Journal of pharmaceutical sciences.

Structural Characterization and Formulation Development of a Trivalent Equine Encephalitis Virus-Like Particle Vaccine Candidate.

S. Joshi, D. Volkin, R. Schwartz, 2018, Journal of pharmaceutical sciences.

Stabilization and formulation of a recombinant Human Cytomegalovirus vector for use as a candidate HIV-1 vaccine

K. Früh, S. Joshi, D. Volkin, 2019, Vaccine.

Formulation and stabilization of a recombinant human Cytomegalovirus vector for use as a candidate vaccine for HIV-1

S. Joshi, D. Volkin, Ozan S. Kumru, 2018 .

Developability assessments of monoclonal antibody candidates to minimize aggregation during large-scale ultrafiltration and diafiltration (UF-DF) processing.

S. Joshi, D. Volkin, P. Dhar, 2022, Journal of pharmaceutical sciences.

Formulation development of a plant-derived h1n1 influenza vaccine containing purified recombinant hemagglutinin antigen

Vidyashankara G. Iyer, S. Joshi, Y. Shoji, 2012, Human vaccines & immunotherapeutics.

Chemical Stability of the Botanical Drug Substance Crofelemer: A Model System for Comparative Characterization of Complex Mixture Drugs.

Eric J. Deeds, Peter A Kleindl, Maulik K. Nariya, 2017, Journal of pharmaceutical sciences.

Multi-dose Formulation Development for a Quadrivalent Human Papillomavirus Virus-Like Particle-Based Vaccine: Part I- Screening of Preservative Combinations.

S. Joshi, D. Volkin, S. Brendle, 2022, Journal of pharmaceutical sciences.

Stability of the Clostridium botulinum type A neurotoxin complex: an empirical phase diagram based approach.

Aaron M. Smalter, S. Joshi, B. Steadman, 2007, Molecular pharmaceutics.

Mechanism of a decrease in potency for the recombinant influenza A virus hemagglutinin H3 antigen during storage.

B. Buckland, S. Joshi, D. Volkin, 2014, Journal of pharmaceutical sciences.

Formulation Studies to Develop Low-cost, Orally-delivered Secretory IgA Monoclonal Antibodies for Passive Immunization Against Enterotoxigenic Escherichia coli.

M. Klempner, L. Cavacini, S. Joshi, 2023, Journal of pharmaceutical sciences.

Formulation and immunogenicity studies of type III secretion system needle antigens as vaccine candidates.

S. Joshi, W. Picking, R. Esfandiary, 2010, Journal of pharmaceutical sciences.

Development of a high-throughput RT-PCR based viral infectivity assay for monitoring the stability of a replicating recombinant Lymphocytic Choriomeningitis viral vector

S. Joshi, D. Volkin, G. Fuhrmann, 2021, Journal of Virological Methods.

Biophysical characterization of the type III secretion tip proteins and the tip proteins attached to bacterium-like particles.

S. Joshi, W. Picking, W. Picking, 2015, Journal of pharmaceutical sciences.

Impact of Detergent on Biophysical Properties and Immune Response of the IpaDB Fusion Protein, a Candidate Subunit Vaccine against Shigella Species

S. Joshi, W. Picking, J. Clements, 2014, Infection and Immunity.

Improved data visualization techniques for analyzing macromolecule structural changes

C Russell Middaugh, Vidyashankara G. Iyer, Sangeeta B Joshi, 2012, Protein science : a publication of the Protein Society.

A ferritin-based COVID-19 nanoparticle vaccine that elicits robust, durable, broad-spectrum neutralizing antisera in non-human primates

B. Pulendran, M. Feinberg, S. Joshi, 2023, Nature communications.

Nanoalum Formulations Containing Aluminum Hydroxide and CpG 1018TM Adjuvants: The Effect on Stability and Immunogenicity of a Recombinant SARS-CoV-2 RBD Antigen.

J. C. Love, Sergio A. Rodriguez-Aponte, S. Joshi, 2023, Vaccines.

Advances in vaccines against neglected tropical diseases

P. Hotez, S. Joshi, M. Bottazzi, 2012, Human vaccines & immunotherapeutics.

Biophysical characterization of rotavirus serotypes G1, G3, and G4

S. Joshi, V. Truong-Le, R. Esfandiary, 2010, Human vaccines.

Correlating physicochemical and biological properties to define critical quality attributes of a rAAV vaccine candidate

S. Joshi, D. Volkin, L. Vandenberghe, 2023, Molecular Therapy - Methods & Clinical Development.

Temperature dependent 2nd derivative absorbance spectroscopy of aromatic amino acids as a probe of protein dynamics

S. Joshi, G. Lushington, R. Esfandiary, 2009, Protein science : a publication of the Protein Society.

Formulation Development and Improved Stability of a Combination Measles and Rubella Live-Viral Vaccine Dried for Use in the NanopatchTM Microneedle Delivery System

S. Joshi, D. Volkin, Paul V Fahey, 2021, Human vaccines & immunotherapeutics.

Characterization of the physical stability of a lyophilized IgG1 mAb after accelerated shipping-like stress.

Srivalli Telikepalli, C Russell Middaugh, Sangeeta B Joshi, 2015, Journal of pharmaceutical sciences.

Effects of aluminum-salt, CpG and emulsion adjuvants on the stability and immunogenicity of a virus-like particle displaying the SARS-CoV-2 receptor-binding domain (RBD)

K. Kaur, S. Joshi, D. Volkin, 2023, bioRxiv.

A C-terminal Pfs48/45 malaria transmission-blocking vaccine candidate produced in the baculovirus expression system

S. Joshi, D. Volkin, C. King, 2020, Scientific Reports.

Biophysical and stabilization studies of the Chlamydia trachomatis mouse pneumonitis major outer membrane protein.

S. Joshi, M. Bottazzi, Sumin Cai, 2009, Molecular pharmaceutics.

Structural Characterization and Physicochemical Stability Profile of a Double Mutant Heat Labile Toxin Protein Based Adjuvant

S. Joshi, D. Volkin, J. Hickey, 2017, Journal of pharmaceutical sciences.

A formulation method to improve the physical stability of macromolecular-based drug products

Santosh V. Thakkar, S. Joshi, C. Middaugh, 2012 .

The Use of a GroEL-BLI Biosensor to Rapidly Assess Preaggregate Populations for Antibody Solutions Exhibiting Different Stability Profiles.

S. Joshi, S. Bishop, D. Volkin, 2018, Journal of pharmaceutical sciences.

Studies of the aggregation of RNase Sa.

S. Joshi, D. Volkin, R. Kramer, 2014, Journal of pharmaceutical sciences.

Structural stability of vault particles.

V. Kickhoefer, L. Rome, S. Joshi, 2009, Journal of pharmaceutical sciences.

BIOTECHNOLOGY Structural Stability of Vault Particles

V. Kickhoefer, L. Rome, S. Joshi, 2009 .