M. Gaczynska

发表

A tetrahedral transition state at the active sites of the 20S proteasome is coupled to opening of the alpha-ring channel.

M. Hochstrasser, P. Osmulski, M. Gaczynska, 2009, Structure.

Characterization of noncompetitive regulators of proteasome activity.

P. Osmulski, M. Gaczynska, 2005, Methods in enzymology.

Single‐Cell Molecular Profiles and Biophysical Assessment of Circulating Tumor Cells

P. Osmulski, M. Gaczynska, D. Mahalingam, 2016 .

Potential allosteric modulators of the proteasome activity.

E. Jankowska, P. Osmulski, M. Gaczynska, 2010, Biopolymers.

Molecular mechanisms of proteasome plasticity in aging

P. Osmulski, M. Gaczynska, K. Rodriguez, 2010, Mechanisms of Ageing and Development.

Proteasome, Chemistry of

P. Osmulski, M. Gaczynska, M. Tokmina-Lukaszewska, 2008 .

Proline- and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity.

P. Osmulski, M. Gaczynska, M. Simons, 2003, Biochemistry.

Atomic force microscopy of the proteasome.

P. Osmulski, M. Gaczynska, 2005, Methods in enzymology.

Single-Cell Proteomic Profiling Identifies Combined AXL and JAK1 Inhibition as a Novel Therapeutic Strategy for Lung Cancer

T. Huang, P. Osmulski, M. Gaczynska, 2020, Cancer Research.

Cellular cholesterol regulates monocyte deformation.

Amit Kumar Saha, Anand K. Ramasubramanian, T. Huang, 2017, Journal of biomechanics.

A new large proteolytic complex distinct from the proteasome is present in the cytosol of fission yeast

P. Osmulski, M. Gaczynska, 1998, Current Biology.

Molecular Characteristics of Multicorn, a New Large Proteolytic Assembly and Potential Anti-Cancer Drug Target, in Human Breast Cancer Cells

M. Gaczynska, 2005 .

Pipecolic esters as minimized templates for proteasome inhibition.

P. Osmulski, M. Gaczynska, J. Tepe, 2019, Organic & biomolecular chemistry.

Single‐cell analysis of circulating tumor cells identifies cumulative expression patterns of EMT‐related genes in metastatic prostate cancer

I. Thompson, Luzhe Sun, T. Huang, 2013, The Prostate.

Proteasome inhibitors and antigen presentation.

M. Bogyo, H. Ploegh, M. Gaczynska, 1997, Biopolymers.

Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health

S. Austad, S. Shoelson, P. Osmulski, 2017, Aging cell.

Adipokines Deregulate Cellular Communication via Epigenetic Repression of Gap Junction Loci in Obese Endometrial Cancer.

P. Goodfellow, Jianhua Ruan, V. Jin, 2018, Cancer research.

Hyperthermia, unlike ionizing radiation and chemical oxidative stress, does not stimulate proteolysis in erythrocytes.

M. Gaczynska, G. Bartosz, E. Grzelińska, 1990, The International journal of biochemistry.

Changes in the proteolytic activity of human erythrocyte membrane during red cell aging.

M. Gaczynska, Maria E Gaczynska, 1989, Biochimica et biophysica acta.

The proteasome in health and disease.

E. Jankowska, P. Osmulski, M. Gaczynska, 2012, Current pharmaceutical design.

Role of proteasomes in antigen presentation.

A. Goldberg, K. Rock, M. Gaczynska, 1993, Enzyme & protein.

Peptide vinyl sulfones : inhibitors and active site probes for the study of proteasome function in vivo

M. Bogyo, H. Ploegh, M. Gaczynska, 1997 .

AFM Imaging Reveals Topographic Diversity of Wild Type and Z Variant Polymers of Human α1-Proteinase Inhibitor

P. Osmulski, M. Gaczynska, J. Teckman, 2016, PloS one.

Amyloid beta and the longest-lived rodent: the naked mole-rat as a model for natural protection from Alzheimer's disease

Yael H. Edrey, P. Osmulski, M. Gaczynska, 2013, Neurobiology of Aging.

A Role for the Proteasome Alpha2 Subunit N-Tail in Substrate Processing

M. Glickman, N. Reis, P. Osmulski, 2023, bioRxiv.

Androgen deprivation-induced elevated nuclear SIRT1 promotes prostate tumor cell survival by reactivation of AR signaling.

Y. Chen, P. Osmulski, M. Gaczynska, 2021, Cancer letters.

Dissecting a role of a charge and conformation of Tat2 peptide in allosteric regulation of 20S proteasome

E. Jankowska, P. Osmulski, M. Gaczynska, 2014, Journal of peptide science : an official publication of the European Peptide Society.

AFM of biological complexes: what can we learn?

P. Osmulski, M. Gaczynska, 2008, Current opinion in colloid & interface science.

Contacts with Macrophages Promote an Aggressive Nanomechanical Phenotype of Circulating Tumor Cells in Prostate Cancer

I. Thompson, T. Huang, P. Osmulski, 2021, Cancer Research.

Self-digestion of erythrocyte membranes of various mammalian species.

M. Gaczynska, G. Bartosz, M. Soszyński, 1988, Comparative biochemistry and physiology. B, Comparative biochemistry.

Highbrow proteasome in high-throughput technology

P. Osmulski, M. Gaczynska, S. Madabhushi, 2006, Expert review of proteomics.

Peptidase activities of proteasomes are differentially regulated by the major histocompatibility complex-encoded genes for LMP2 and LMP7.

A. Goldberg, K. Rock, M. Gaczynska, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Proteolytic activity of human erythrocyte membrane during ghosts preparation.

M. Gaczynska, G. Bartosz, 1989, The International journal of biochemistry.

Scanning tunneling microscopy of human erythrocyte membranes.

M. Gaczynska, G. Bartosz, W. Olejniczak, 1991, Biochemical and biophysical research communications.

Proteolytic self-digestion of bovine erythrocyte membranes.

M. Gaczynska, G. Bartosz, M. Soszyński, 1985, The International journal of biochemistry.

Proteolytic activity in electropherograms (SDS-PAGE) of bovine erythrocyte ghosts.

M. Gaczynska, 1988, The International journal of biochemistry.

Phosphorylation by Nek1 regulates opening and closing of voltage dependent anion channel 1.

D. Riley, R. Polci, Yumay Chen, 2010, Biochemical and biophysical research communications.

The Growth-Suppressive Function of the Polycomb Group Protein Polyhomeotic Is Mediated by Polymerization of Its Sterile Alpha Motif (SAM) Domain*

A. Hinck, P. Osmulski, M. Gaczynska, 2012, The Journal of Biological Chemistry.

Single‐cell analysis of circulating tumor cells identifies cumulative expression patterns of EMT‐related genes in metastatic prostate cancer

I. Thompson, Luzhe Sun, T. Huang, 2013, The Prostate.

Altered Composition of Liver Proteasome Assemblies Contributes to Enhanced Proteasome Activity in the Exceptionally Long-Lived Naked Mole-Rat

Yael H. Edrey, P. Osmulski, M. Gaczynska, 2012, PloS one.

A proteolytic system that compensates for loss of proteasome function

M. Bogyo, H. Ploegh, M. Gaczynska, 1998, Nature.

Caretaker or undertaker? The role of the proteasome in aging

P. Osmulski, M. Gaczynska, W. Ward, 2001, Mechanisms of Ageing and Development.

Effect of thiol modification on the thermal stability of erythrocyte membranes

M. Gaczynska, Z. Jóźwiak, M. Soszyński, 1994 .

Genetic and pharmacologic proteasome augmentation ameliorates Alzheimer’s-like pathology in mouse and fly APP overexpression models

E. Jankowska, P. Osmulski, M. Gaczynska, 2022, Science advances.

EpCAM-RegulatedTranscriptionExerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to- Mesenchymal Transition

Jianhua Ruan, V. Jin, Yao Wang, 2017 .

EpCAM-Regulated Transcription Exerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to-Mesenchymal Transition.

Jianhua Ruan, V. Jin, Yao Wang, 2016, Cancer research.

Nanomechanical biomarkers of single circulating tumor cells for detection of castration resistant prostate cancer

Ian M Thompson, I. Thompson, P. Osmulski, 2014, The Prostate.

Proteolytic susceptibility of membrane proteins during erythrocyte aging

M. Gaczynska, G. Bartosz, M. Soszyński, 1986, Mechanisms of Ageing and Development.

Abnormal degradation of erythrocyte membrane proteins in Down's syndrome.

M. Gaczynska, G. Bartosz, J. Kȩdziora, 2008, Hereditas.

Covalent modification of the active site threonine of proteasomal beta subunits and the Escherichia coli homolog HslV by a new class of inhibitors.

A. Goldberg, M. Bogyo, H. Ploegh, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Functions of the proteasome in antigen presentation.

A. Goldberg, K. Rock, M. Gaczynska, 1995, Cold Spring Harbor symposia on quantitative biology.

Functions of the proteasome in antigen presentation.

A. Goldberg, K. Rock, M. Gaczynska, 1995, Cold Spring Harbor symposia on quantitative biology.

DNA-looping by RXR tetramers permits transcriptional regulation "at a distance".

P. Osmulski, M. Gaczynska, N. Noy, 2004, Journal of molecular biology.

Gamma-interferon and expression of MHC genes regulate peptide hydrolysis by proteasomes.

A. Goldberg, K. Rock, M. Gaczynska, 1993, Nature.

Inhibitory Interplay of SULT2B1b Sulfotransferase with AKR1C3 Aldo-keto Reductase in Prostate Cancer.

Yidong Chen, P. Osmulski, M. Gaczynska, 2020, Endocrinology.

Atomic force microscopic analysis of the binding of the Schizosaccharomyces pombe origin recognition complex and the spOrc4 protein with origin DNA

J. Hurwitz, P. Osmulski, M. Gaczynska, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Altered peptidase and viral-specific T cell response in LMP2 mutant mice.

S. Tonegawa, A. Goldberg, M. Eichelberger, 1994, Immunity.

Harnessing proteasome dynamics and allostery in drug design.

P. Osmulski, M. Gaczynska, 2014, Antioxidants & redox signaling.

Lactacystin and clasto-Lactacystin β-Lactone Modify Multiple Proteasome β-Subunits and Inhibit Intracellular Protein Degradation and Major Histocompatibility Complex Class I Antigen Presentation*

A. Goldberg, K. Rock, A. Craiu, 1997, The Journal of Biological Chemistry.

A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition.

S. Weintraub, P. Osmulski, M. Gaczynska, 2014, Biochimica et biophysica acta.

Small-molecule inhibitors of proteasome activity.

P. Osmulski, M. Gaczynska, 2005, Methods in molecular biology.

Rapamycin Allosterically Inhibits the Proteasome

P. Osmulski, M. Gaczynska, 2013, Molecular Pharmacology.

Standardization of the electron spin resonance method for the proteolytic activity assay.

M. Gaczynska, G. Bartosz, 1989, Journal of biochemical and biophysical methods.

Cholesterol Regulates Monocyte Rolling through CD44 Distribution.

Amit Kumar Saha, Anand K. Ramasubramanian, T. Huang, 2017, Biophysical journal.

Small Molecule Modulation of Proteasome Assembly.

P. Osmulski, M. Gaczynska, J. Tepe, 2018, Biochemistry.

Targeting Protein-Protein Interactions in the Ubiquitin-Proteasome Pathway.

P. Osmulski, M. Gaczynska, 2018, Advances in protein chemistry and structural biology.

Interplay between Structure and Charge as a Key to Allosteric Modulation of Human 20S Proteasome by the Basic Fragment of HIV-1 Tat Protein

E. Jankowska, P. Osmulski, M. Gaczynska, 2015, PloS one.

The central unit within the 19S regulatory particle of the proteasome

M. Glickman, P. Osmulski, M. Gaczynska, 2008, Nature Structural &Molecular Biology.

Atomic force microscopy as a tool to study the proteasome assemblies.

P. Osmulski, M. Gaczynska, 2008, Methods in cell biology.

Abstract 2193: AXL inhibitor TP-0903 attenuates AXL-TGFbeta Hippo signaling axis in lung adenocarcinoma cells

T. Huang, P. Osmulski, M. Gaczynska, 2019, Experimental and Molecular Therapeutics.

The binding of a polyclonal antibody against human band 3 to in vitro aged erythrocytes.

M. Gaczynska, K. Halbhuber, H. Feuerstein, 1990, Acta histochemica.

Effect of proteolysis on the electron spin resonance spectra of maleimide spin labeled erythrocyte membrane.

M. Gaczynska, G. Bartosz, 1985, Biochimica et biophysica acta.

Consequences of the presence of elongated variant of the major transmembrane protein (Band 3 protein) in the human erythrocyte.

M. Gaczynska, G. Bartosz, W. Retelewska, 1991, Clinica chimica acta; international journal of clinical chemistry.

Endogenous proteolysis of the human erythrocyte membrane as studied by two-dimensional gel electrophoresis and electron spin resonance.

M. Gaczynska, G. Bartosz, P. Gromov, 1989, The International journal of biochemistry.

A spin-label study of membrane proteins and internal microviscosity of erythrocytes in hereditary spherocytosis.

M. Gaczynska, G. Bartosz, E. Grzelińska, 1987, Life Science.

Abnormal degradation of erythrocyte membrane proteins in hereditary spherocytosis.

M. Gaczynska, G. Bartosz, J. Rosin, 1987, Clinica chimica acta; international journal of clinical chemistry.

Atomic Force Microscopy Reveals Two Conformations of the 20 S Proteasome from Fission Yeast*

P. Osmulski, M. Gaczynska, 2000, The Journal of Biological Chemistry.

Proteasome Subunits X and Y Alter Peptidase Activities in Opposite Ways to the Interferon-γ-induced Subunits LMP2 and LMP7*

A. Goldberg, K. Rock, M. Gaczynska, 1996, The Journal of Biological Chemistry.

New Peptide-Based Pharmacophore Activates 20S Proteasome

E. Jankowska, P. Osmulski, M. Gaczynska, 2020, Molecules.

TGF-β signal rewiring sustains epithelial-mesenchymal transition of circulating tumor cells in prostate cancer xenograft hosts

I. Thompson, Luzhe Sun, T. Huang, 2016, Oncotarget.

Proline- and Arginine-Rich Peptides as Flexible Allosteric Modulators of Human Proteasome Activity

E. Jankowska, P. Osmulski, M. Gaczynska, 2018, Journal of medicinal chemistry.

Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy

Z. Ungvari, P. Osmulski, M. Gaczynska, 2023, Nature communications.

Changes in proteolytic susceptibility of human erythrocyte membrane proteins during red blood cell aging.

M. Gaczynska, 1992, Cytobios.

Crosslinking of membrane proteins during erythrocyte ageing.

M. Gaczynska, G. Bartosz, 1986, International Journal of Biochemistry.

Aged erythrocytes exhibit decreased anion exchange

M. Gaczynska, G. Bartosz, E. Grzelińska, 1987, Mechanisms of Ageing and Development.

γ-lnterferon and expression of MHC genes regulate peptide hydrolysis by proteasomes

A. Goldberg, K. Rock, M. Gaczynska, 1995, Nature.

Endometrial Gap Junction Expression - Early Indicators of Endometriosis and Integral to Invasiveness

Jianhua Ruan, P. Osmulski, M. Gaczynska, 2021, bioRxiv.

Unwound nature of MAR-capable AT-rich DNA domains (AT-islands) targeted by a highly AT-specific drug bizelesin

P. Osmulski, M. Gaczynska, J. Jackson, 2006 .

Targeting Protein-Protein Interactions in the Proteasome Super-Assemblies.

P. Osmulski, M. Gaczynska, 2015, Current Topics in Medicinal Chemistry.

Running title : Rapamycin allosterically inhibits the proteasome

P. Osmulski, M. Gaczynska, 2013 .

Allosteric regulators of the proteasome: potential drugs and a novel approach for drug design.

P. Osmulski, M. Gaczynska, Xiao-ming Tan, 2006, Current medicinal chemistry.

Electronic Circular Dichroism Detects Conformational Changes Associated with Proteasome Gating Confirmed Using AFM Imaging

P. Osmulski, M. Gaczynska, R. Purrello, 2023, Biomolecules.

Small Molecule Modulation of Proteasome Assembly.

P. Osmulski, M. Gaczynska, J. Tepe, 2018, Biochemistry.

AXL-initiated paracrine activation of pSTAT3 enhances mesenchymal and vasculogenic supportive features of tumor-associated macrophages

J. Michalek, D. Gibbons, P. Osmulski, 2023, Cell reports.

Phagocytosis-initiated tumor hybrid cells acquire a c-Myc-mediated quasi-polarization state for immunoevasion and distant dissemination

P. Osmulski, M. Gaczynska, Chia-Nung Hung, 2023, Nature communications.

Targeting Protein-Protein Interactions in the Ubiquitin-Proteasome Pathway.

P. Osmulski, M. Gaczynska, 2018, Advances in protein chemistry and structural biology.

Ex vivo drug testing of patient-derived lung organoids to predict treatment responses for personalized medicine.

P. Osmulski, M. Gaczynska, Meena Kusi, 2024, Lung cancer.

PAI-1 uncouples integrin-β1 from restrain by membrane-bound β-catenin to promote collagen fibril remodeling in obesity-related neoplasms.

M. Gaczynska, Chiou-Miin Wang, N. Kirma, 2024, Cell reports.

Atomic force microscopy of proteasome assemblies.

P. Osmulski, M. Gaczynska, 2011, Methods in molecular biology.

Nanoenzymology of the 20S proteasome: proteasomal actions are controlled by the allosteric transition.

P. Osmulski, M. Gaczynska, 2002, Biochemistry.