N. Birdsall

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Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors.

S. Lazareno, N. Birdsall, N J Birdsall, 1995, Molecular pharmacology.

Modification of the binding properties of muscarinic receptors by gallamine.

N. Birdsall, E. Hulme, J. Stockton, 1983, Molecular pharmacology.

International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors.

N. Birdsall, M. Caulfield, N. Birdsall, 1998, Pharmacological reviews.

Pharmacological characterization of acetylcholine‐stimulated [35S]‐GTPγS binding mediated by human muscarinic m1–m4 receptors: antagonist studies

S. Lazareno, N. Birdsall, N. Birdsall, 1993, British journal of pharmacology.

Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng‐Prusoíf equations

S. Lazareno, N. Birdsall, S. Lazareno, 1993, British journal of pharmacology.

Nuclear Magnetic Relaxation and the Biological Membrane

N. Birdsall, A. Lee, J. Metcalfe, 1974 .

Allosteric Regulation of Binding and Function at GCPRS

S. Lazareno, N. Birdsall, C. Browning, 2004, Medicinal Chemistry Research.

Pharmacological characterization of guanine nucleotide exchange reactions in membranes from CHO cells stably transfected with human muscarinic receptors m1-m4.

S. Lazareno, N. Birdsall, T. Farries, 1993, Life sciences.

Calculation of dipolar nuclear magnetic relaxation times in molecules with multiple internal rotations. II. Theoretical results for anisotropic over‐all motion of the molecule, and comparison with 13C relaxation times in n ‐alkanes and n ‐alkyl bromides

G. Roberts, N. Birdsall, A. Lee, 1974 .

The binding of agonists to brain muscarinic receptors.

N. Birdsall, E. Hulme, A. Burgen, 1978, Molecular pharmacology.

The Binding Properties of Muscarinic Receptors

N. Birdsall, E. Hulme, 1989 .

To What Extent Can Binding Studies Allow the Quantification of Affinity and Efficacy?

S. Lazareno, N. Birdsall, N. Birdsall, 1997, Annals of the New York Academy of Sciences.

The structure and properties of the purified muscarinic acetylcholine receptor from rat forebrain.

N. Birdsall, E. Hulme, M. Wheatley, 1987, Biochemical Society transactions.

Class A GPCR heterodimers: evidence from binding studies.

N. Birdsall, 2010, Trends in pharmacological sciences.

Use of clonal cell lines in the analysis of neurotransmitter receptor mechanisms and function.

N. Birdsall, E. Hulme, N. Buckley, 1990, Biochimica et biophysica acta.

Cholesterol is excluded from the phospholipid annulus surrounding an active calcium transport protein

M. Houslay, N. Birdsall, J. Metcalfe, 1975, Nature.

Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors.

S. Lazareno, N. Birdsall, P. Gharagozloo, 1999, Journal of medicinal chemistry.

Reconstitution of a calcium pump using defined membrane components.

N. Birdsall, A. Lee, J. Metcalfe, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Muscarinic receptor subtypes and the selectivity of agonists and antagonists.

N. Birdsall, E. Hulme, M. Wheatley, 1988, Pharmacology.

Modulation of the binding properties of muscarinic receptors: evidence for receptor-effector coupling.

N. Birdsall, E. Hulme, A. Burgen, 1980, Advances in biochemical psychopharmacology.

The character of the muscarinic receptors in different regions of the rat brain

N. Birdsall, E. Hulme, A. Burgen, 1980, Proceedings of the Royal Society of London. Series B. Biological Sciences.

Purine N-oxides—XLI : The 3-acyloxypurine 8-substitution reaction: On the mechanism of the reaction

N. Birdsall, J. Parham, U. Woelcke, 1972 .

Correlations between oncogenic and chemical properties of several derivatives of 3-hydroxyxanthine and 3-hydroxyguanine.

N. Birdsall, J. Parham, G. B. Brown, 1973, Cancer research.

Purine n-oxides XXIV. The preparation of 8-substituted xanthines and guanines by a nucleophilic displacement of a 3-substituent

N. Birdsall, G. B. Brown, U. Woelcke, 1969 .

Clusters in lipid bilayers and the interpretation of thermal effects in biological membranes.

N. Birdsall, A. Lee, J. Metcalfe, 1974, Biochemistry.

Allosteric interactions between the antagonist prazosin and amiloride analogs at the human alpha(1A)-adrenergic receptor.

S. Lazareno, N. Birdsall, R. Leppik, 2000, Molecular pharmacology.

Muscarinic interactions of bisindolylmaleimide analogues.

S. Lazareno, N. Birdsall, A. Popham, 1998, European journal of pharmacology.

Agonist binding and function at the human alpha(2A)-adrenoceptor: allosteric modulation by amilorides.

N. Birdsall, R. Leppik, 2000, Molecular pharmacology.

Quantitation of allosteric interactions.

S. Lazareno, N. Birdsall, 1996, Trends in pharmacological sciences.

Characterization of the allosteric interactions between antagonists and amiloride analogues at the human alpha2A-adrenergic receptor.

S. Lazareno, N. Birdsall, R. Leppik, 1998, Molecular pharmacology.

Multiple allosteric sites on muscarinic receptors.

J. Saldanha, S. Lazareno, N. Birdsall, 2001, Life sciences.

Allosteric regulation of muscarinic receptors.

S. Lazareno, N. Birdsall, H. Matsui, 1996, Progress in brain research.

Depolarisation-induced changes in muscarinic cholinergic receptors in synaptosomes

H. Bradford, N. Birdsall, E. Hulme, 1979, Nature.

Molecular biology: Distinctions in acetylcholine receptor activity

N. Birdsall, E. Hulme, 1986, Nature.

Guanine nucleotide modulation of muscarinic cholinergic receptor binding in postmortem human brain — A preliminary study in Alzheimer's disease

E. Perry, N. Birdsall, R. Perry, 1987, Neuroscience Letters.

The binding of pirenzepine to digitonin‐solubilized muscarinic acetylcholine receptors from the rat myocardium

N. Birdsall, E. Hulme, M. Keen, 1986, British journal of pharmacology.

The affinity, selectivity and biological activity of telenzepine enantiomers.

N. Birdsall, R. Boer, C. Schudt, 1989, European journal of pharmacology.

Modulation of the structure‐binding relationships of antagonists for muscarinic acetylcholine receptor subtypes

N. Birdsall, E. Hulme, D. Poyner, 1991, British journal of pharmacology.

Two populations of binding sites for muscarinic antagonists in the rat heart.

N. Birdsall, E. Hulme, A. Burgen, 1981, European journal of pharmacology.

Two Drug Binding Sites on Muscarinic Receptors

N. Birdsall, E. Hulme, J. Stockton, 1986 .

Differences in the Agonist Binding Properties of Muscarinic Receptor Subpopulations in the Rat Cerebral Cortex and Myocardium

N. Birdsall, E. Hulme, 1986 .

Regulation of muscarinic agonist binding by cations and guanine nucleotides.

N. Birdsall, E. Hulme, J. Stockton, 1983, European journal of pharmacology.

Effect of tityus toxin and sensory stimulation on muscarinic cholinergic receptors in vivo.

H. Bradford, N. Birdsall, E. Hulme, 1981, Biochemical pharmacology.

Receptor biochemistry : a practical approach

N. Birdsall, E. Hulme, 1990 .

Guanine nucleotides modulate muscarinic receptor binding in the heart.

N. Birdsall, E. Hulme, A. Burgen, 1979, Biochemical and biophysical research communications.

Sobs Annual Report | | 2008 80 Primary

J. Whisstock, P. Taylor, L. Poston, 2022 .

Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity.

S. Lazareno, N. Birdsall, A. Popham, 2004, Molecular pharmacology.

Ontogeny of muscarinic receptors in rat brain

M. Kuhar, N. Birdsall, E. Hulme, 1980, Brain Research.

Allosteric regulation of G-protein-linked receptors.

S. Lazareno, N. Birdsall, H. Matsui, 1995, Biochemical Society transactions.

Hydrodynamic properties of muscarinic acetylcholine receptors solubilized from rat forebrain

N. Birdsall, E. Hulme, T. Haga, 1984, British journal of pharmacology.

Effects of contamination on radioligand binding parameters.

S. Lazareno, N. Birdsall, 2000, Trends in pharmacological sciences.

Receptor structure: the accelerating impact of molecular biology.

N. Birdsall, 1989, Trends in pharmacological sciences.

Regional distribution of muscarinic and nicotinic cholinergic receptor binding activities in the human brain.

E. Perry, N. Birdsall, R. Perry, 1989, Journal of chemical neuroanatomy.

The interaction of paramagnetic ions and spin labels with lecithin bilayers.

N. Birdsall, A. Lee, J. Robinson, 1973, Biochimica et biophysica acta.

The effects of saponin on the binding and functional properties of the human adenosine A1 receptor

S. Lazareno, N. Birdsall, N. Birdsall, 1996, British journal of pharmacology.

Strategy in Receptor Binding Studies

N. Birdsall, E. Hulme, N. Birdsall, 1984 .

Recent Advances in Muscarinic Receptor Pharmacology & Therapeutics

N. Birdsall, R. Eglen, C. Felder, 2008 .

13C Nuclear magnetic relaxation times and models for chain motion in lecithin vesicles

G. Roberts, N. Birdsall, A. Lee, 1972, FEBS letters.

Peptide mapping studies on muscarinic receptors: receptor structure and location of the ligand binding site.

N. Birdsall, E. Hulme, M. Wheatley, 1988, Trends in pharmacological sciences.

The existence of stable enantiomers of telenzepine and their stereoselective interaction with muscarinic receptor subtypes.

N. Birdsall, E. Hulme, C. Schudt, 1989, Molecular pharmacology.

CORTICAL MUSCARINIC RECEPTOR SUBTYPES AND ALZHEIMER'S DISEASE

T. Crow, N. Birdsall, A. Cross, 1982, The Lancet.

The affinity of adenosine for the high- and low-affinity states of the human adenosine A1 receptor.

S. Lazareno, N. Birdsall, F. Cohen, 1996, European journal of pharmacology.

Progress toward a high-affinity allosteric enhancer at muscarinic M1 receptors

S. Lazareno, N. Birdsall, A. Popham, 2007, Journal of Molecular Neuroscience.

19 F NMR of monofluorostearic acids in lecithin vesicles.

N. Birdsall, J. Metcalfe, Y. K. Levine, 1971, Biochimica et biophysica acta.

Analogs of WIN 62,577 define a second allosteric site on muscarinic receptors.

S. Lazareno, N. Birdsall, S Lazareno, 2002, Molecular pharmacology.

A nuclear magnetic resonance investigation of the conformation of nicotinamide mononucleotide in aqueous solution.

J. Thornton, J. Feeney, N. Birdsall, 1975, Journal of the American Chemical Society.

High resolution proton relaxation studies of lecithins.

N. Birdsall, N J Birdsall, A G Lee, 1972, Biochimica et biophysica acta.

Allosterism at muscarinic receptors: ligands and mechanisms.

S. Lazareno, N. Birdsall, 2005, Mini reviews in medicinal chemistry.

Dipalmitoyl-lecithin: assignment of the 1H and 13C nuclear magnetic resonance spectra, and conformational studies

J. Feeney, N. Birdsall, J. Metcalfe, 1972 .

A simple synthesis of monofluorostearic acids

N. Birdsall, 1971 .

Annular lipids determine the ATPase activity of a calcium transport protein complexed with dipalmitoyllecithin.

M. Houslay, N. Birdsall, G. Smith, 1976, Biochemistry.

Reversible lipid titrations of the activity of pure adenosine triphosphatase-lipid complexes.

N. Birdsall, J. Metcalfe, G. B. Warren, 1974, Biochemistry.

Complete control of the lipid environment of membrane‐bound proteins: Application to a calcium transport system

N. Birdsall, J. Metcalfe, G. B. Warren, 1974, FEBS letters.

13 C nuclear magnetic resonance relaxation measurements of synthetic lecithins and the effect of spin-labeled lipids.

N. Birdsall, J. Metcalfe, Y. K. Levine, 1972, Biochemistry.

13 C and 1 H nuclear magnetic resonance relaxation measurements of the lipids of sarcoplasmic reticulum membranes.

N. Birdsall, J. Robinson, J. Metcalfe, 1972, Biochemistry.

A NUCLEAR MAGNETIC RESONANCE INVESTIGATION OF THE CONFORMATION OF NICOTINAMIDE MONONUCLEOTIDE IN AQUEOUS SOLUTION

J. Thornton, J. Feeney, N. Birdsall, 1975 .

Pirenzepine distinguishes between different subclasses of muscarinic receptors

N. Birdsall, E. Hulme, A. Burgen, 1980, Nature.

Purine N-oxides—LII

N. Birdsall, U. Woelcke, G. B. Brown, 1971 .

Muscarinic receptor subtypes.

N. Birdsall, E. Hulme, N. Buckley, 1990, Annual review of pharmacology and toxicology.

Pirenzepine--a ligand with original binding properties to muscarinic receptors.

N. Birdsall, E. Hulme, J. Stockton, 1980, Scandinavian journal of gastroenterology. Supplement.

Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: functional studies.

S. Lazareno, N. Birdsall, P. Gharagozloo, 1999, Molecular pharmacology.

Purine N-oxides—XXXIX N-acetoxy derivatives of N-hydroxyxanthines

N. Birdsall, U. Woelcke, Tzoong-chyh Lee, 1971 .

Simplified 13C spectral assignments using a graphical method to present 13C spectra recorded under conditions of proton off-resonance spin decoupling

J. Feeney, N. Birdsall, B. Birdsall, 1972 .

Muscarinic receptor subclasses: evidence from binding studies.

E. Wong, N. Birdsall, E. Hulme, 1983, Advances in biochemical psychopharmacology.

Solid-state and solution structures of fluorocholine and some analogues: nuclear magnetic resonance and X-ray studies

N. Birdsall, P. Partington, P. Pauling, 1980 .

13C NMR Spectra of Lecithin Vesicles and Erythrocyte Membranes

J. Feeney, N. Birdsall, P. Partington, 1971, Nature.

Measurement of fast lateral diffusion of lipids in vesicles and in biological membranes by 1 H nuclear magnetic resonance.

N. Birdsall, J. Metcalfe, A. Lee, 1973, Biochemistry.

Muscarinic cholinergic receptors: Autoradiographic localization of high and low affinity agonist binding sites

M. Kuhar, N. Birdsall, M. Zarbin, 1980, Brain Research.

Binding of agonists and antagonists to muscarinic receptors.

N. Birdsall, E. Hulme, A. Burgen, 1976, Journal of supramolecular structure.

Muscarinic receptor subclasses

N. Birdsall, E. Hulme, 1983 .

Solubilization and characterization of high and low affinity pirenzepine binding sites from rat cerebral cortex

N. Birdsall, E. Hulme, J. Stockton, 1985, British journal of pharmacology.

Interactions of muscarinic receptors with guanine nucleotides and adenylate cyclase

N. Birdsall, E. Hulme, A. Burgen, 1981 .

Effects of p-chloromercuribenzoate on muscarinic receptor binding in rat brain [proceedings].

E. Wong, N. Birdsall, E. Hulme, 1980, British journal of pharmacology.

Inhibition of high affinity choline uptake. Structure activity studies.

M. Kuhar, N. Birdsall, R. Dehaven, 1980, Biochemical pharmacology.

Cloning and structure-function of the H2 histamine receptor.

N. Birdsall, 1991, Trends in pharmacological sciences.

Enzymic synthesis, characterisation and nuclear-magnetic-resonance spectra of pppA2'p5'A2'p5'A and related oligonucleotides: comparison with chemically synthesised material.

I. Kerr, N. Birdsall, R. Brown, 1979, European journal of biochemistry.

The binding of antagonists to brain muscarinic receptors.

N. Birdsall, E. Hulme, A. Burgen, 1978, Molecular pharmacology.

Acetylcholine receptors (muscarinic) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

C. Langmead, J. Wess, A. Christopoulos, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Selective allosteric enhancement of the binding and actions of acetylcholine at muscarinic receptor subtypes.

S. Lazareno, N. Birdsall, P. Gharagozloo, 1997, Life sciences.

Ligand-binding propeties of the muscarinic acetylcholine receptor in mouse neuroblastoma cells.

N. Birdsall, A. Burgen, P. Strange, 1978, The Biochemical journal.

Propylbenzilylcholine mustard labels an acidic residue in transmembrane helix 3 of the muscarinic receptor.

N. Birdsall, E. Hulme, M. Wheatley, 1989, The Journal of biological chemistry.

Wheel on the sweet smell of success.

N. Birdsall, 1991, Trends in pharmacological sciences.

Allosteric interactions of staurosporine and other indolocarbazoles with N-[methyl-(3)H]scopolamine and acetylcholine at muscarinic receptor subtypes: identification of a second allosteric site.

S. Lazareno, N. Birdsall, A. Popham, 2000, Molecular pharmacology.

Nicotinic and muscarinic cholinergic receptor binding in the human hippocampal formation during development and aging.

Margaret A. Johnson, E K Perry, R H Perry, 1997, Brain research. Developmental brain research.

Occupancy of muscarinic acetylcholine receptors stimulates a guanylate cyclase in neuroblastoma cells.

N. Birdsall, A. Burgen, P. Strange, 1977, Biochemical Society transactions.

Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies.

S. Lazareno, N. Birdsall, P. Gharagozloo, 1998, Molecular pharmacology.

Solubilization andcharacterization ofhigh andlow affinity pirenzepine binding sites fromratcerebral cortex

N. Birdsall, J. Stockton, C. Berrie, 1985 .

Acetylcholine release and muscarinic receptors in cortical synaptosomes from epileptic rats

H. Bradford, N. Birdsall, E. Hulme, 1981, Experimental Neurology.

SOLUBILIZATION AND CHARACTERIZATION OF MUSCARINIC ACETYLCHOLINE RECEPTORS

N. Birdsall, E. Hulme, J. Stockton, 1984 .

Solubilisation and molecular characterisation of muscarinic acetylcholine receptors.

N. Birdsall, E. Hulme, J. Stockton, 1983, Journal of receptor research.

Allosteric Interactions in Receptor Binding Studies

N. Birdsall, E. Hulme, J. Stockton, 1984 .

Estimation of antagonist Kb from inhibition curves in functional experiments: alternatives to the Cheng-Prusoff equation.

S. Lazareno, N. Birdsall, N J Birdsall, 1993, Trends in pharmacological sciences.

Muscarinic cholinergic receptor localization in brain by electron microscopic autoradiography

M. Kuhar, N. Birdsall, E. Hulme, 1981, Brain Research.

Determination of the serum iron-binding capacity

N. Birdsall, D. Kok, F. Wild, 1965, Journal of clinical pathology.

Principles and Methods in Receptor Binding

N. Birdsall, 1985 .

Receptor-effector coupling : a practical approach

N. Birdsall, E. Hulme, 1990 .

The role of the cholinergic system in the development of the human cerebellum.

E. Perry, M. Griffiths, C. Morris, 1995, Brain research. Developmental brain research.

Autoradiographic comparison of cholinergic and other transmitter receptors in the normal human hippocampus

Mary Johnson, E. Perry, C. Morris, 1993, Hippocampus.

13C NMR spectra of acholeplasma membranes containing13C labelled phospholipids

N. Birdsall, J. Metcalfe, A.G. Lee, 1972, FEBS letters.

Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia

A. Christopoulos, F. Bymaster, D. McKinzie, 2008, Proceedings of the National Academy of Sciences.

Probing of the location of the allosteric site on m1 muscarinic receptors by site-directed mutagenesis.

S. Lazareno, N. Birdsall, H. Matsui, 1995, Molecular pharmacology.

Binding and hydrodynamic properties of muscarinic receptor subtypes solubilized in 3-(3-cholamidopropyl)dimethylammonio-2-hydroxy-1-propanesulfonate.

N. Birdsall, E. Hulme, M. Wheatley, 1989, Molecular pharmacology.

Binding properties of reconstituted muscarinic receptors in the absence of G-proteins

N. Birdsall, E. Hulme, D. Poyner, 1989 .

Soluble and membrane-bound muscarinic acetylcholine receptors.

N. Birdsall, E. Hulme, M. Wheatley, 1986, Biochemical Society symposium.

A photoisomerizable muscarinic antagonist. Studies of binding and of conductance relaxations in frog heart

H. Lester, N. Birdsall, J. Stockton, 1982, The Journal of general physiology.

Purification of the muscarinic acetylcholine receptor from rat forebrain.

N. Birdsall, E. Hulme, M. Wheatley, 1985, Biochemical Society Transactions.

The binding of [3H]telenzepine to muscarinic acetylcholine receptors in calf forebrain.

N. Birdsall, C. Schudt, C. Auriga, 1988, European journal of pharmacology.

Cell-free protein synthesis and interferon action: protein kinase(s) and an oligonucleotide effector, pppA2'p5'A2'p5'A.

I. Kerr, B. Williams, N. Birdsall, 1979, Haematology and blood transfusion.

Presynaptic muscarinic receptors on dopaminergic terminals in the nucleus accumbens

J. Belleroche, I. Kilpatrick, N. Birdsall, 1982, Brain Research.

A determination of the mobility gradient in lipid bilayers by 13C nuclear magnetic resonance

G. Roberts, N. Birdsall, J. Metcalfe, 1976, Proceedings of the Royal Society of London. Series B. Biological Sciences.

Competitive binding studies with multiple sites. Effects arising from depletion of the free radioligand.

J. W. Wells, N. Birdsall, E. Hulme, 1980, Biochimica et Biophysica Acta.

Drug receptors and their effectors

N. Birdsall, 1981 .

13C-enriched phosphatidylethanolamines from Escherichia coli.

N. Birdsall, D. Ellar, J. Metcalfe, 1975, Biochimica et biophysica acta.

Allosteric effects of four stereoisomers of a fused indole ring system with 3H-N-methylscopolamine and acetylcholine at M1-M4 muscarinic receptors.

S. Lazareno, N. Birdsall, P. Gharagozloo, 1999, Life Science.

3-(TETRAHYDROPYRIDINYL)INDOLES

N. Birdsall, P. Gharagozloo, M. Miyauchi, 1996 .

3‐(Tetrahydropyridinyl)indoles.

N. Birdsall, P. Gharagozloo, M. Miyauchi, 1996 .

Muscarinic Cholinergic Receptor Localization by Radiohistochemistry

M. Kuhar, N. Birdsall, M. Zarbin, 1981 .

SOLUBILISATION OF THE MUSCARINIC RECEPTOR IN CHAPSO: A COMPARISON WITH THE RECEPTOR IN MEMBRANES AND IN DIGITONIN SOLUTION

N. Birdsall, E. Hulme, M. Wheatley, 1987 .