P. Kiley

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The Influence of Repressor DNA Binding Site Architecture on Transcriptional Control

Dan M. Park, P. Kiley, Patricia J. Kiley, 2014, mBio.

The Bacterial Response Regulator ArcA Uses a Diverse Binding Site Architecture to Regulate Carbon Oxidation Globally

Robert Landick, A. Ansari, Dan M. Park, 2013, PLoS genetics.

Sequence-specific binding to a subset of IscR-regulated promoters does not require IscR Fe-S cluster ligation.

P. Kiley, A. D. Nesbit, J. L. Giel, 2009, Journal of molecular biology.

DNA Binding and Dimerization of the Fe−S-containing FNR Protein from Escherichia coli Are Regulated by Oxygen (*)

P. Kiley, B. Lazazzera, H. Beinert, 1996, The Journal of Biological Chemistry.

Coordinate Regulation of the Suf and Isc Fe-S Cluster Biogenesis Pathways by IscR Is Essential for Viability of Escherichia coli

P. Kiley, Erin Mettert, Patricia J. Kiley, 2014, Journal of bacteriology.

A shared mechanism of SoxR activation by redox‐cycling compounds

P. Kiley, L. Dietrich, Lars E. P. Dietrich, 2011, Molecular microbiology.

Tailoring a Global Iron Regulon to a Uropathogen

Kevin S. Myers, J. Glasner, N. Perna, 2020, mBio.

Exploiting Thiol Modifications

G. Storz, P. Kiley, 2004, PLoS biology.

Complex Physiology and Compound Stress Responses during Fermentation of Alkali-Pretreated Corn Stover Hydrolysate by an Escherichia coli Ethanologen

Venkatesh Balan, B. Dale, J. Reed, 2012, Applied and Environmental Microbiology.

Correcting direct effects of ethanol on translation and transcription machinery confers ethanol tolerance in bacteria

Irene M Ong, Robert Landick, I. Ong, 2014, Proceedings of the National Academy of Sciences.

Design principles of a conditional futile cycle exploited for regulation.

M. Savageau, P. Kiley, J. Lomnitz, 2015, Molecular bioSystems.

Systems metabolic engineering of Escherichia coli improves co-conversion of lignocellulose-derived sugars.

J. Reed, P. Kiley, R. Landick, 2019, Biotechnology journal.

Fnr, NarP, and NarL Regulation of Escherichia coli K-12 napF (Periplasmic Nitrate Reductase) Operon Transcription In Vitro

P. Kiley, V. Stewart, A. J. Darwin, 1998, Journal of bacteriology.

Cloning, DNA sequence, and expression of the Rhodobacter sphaeroides light-harvesting B800-850-alpha and B800-850-beta genes

P. Kiley, S. Kaplan, 1987, Journal of bacteriology.

Molecular genetics of photosynthetic membrane biosynthesis in Rhodobacter sphaeroides.

P. Kiley, S. Kaplan, 1988, Microbiological reviews.

Iron availability and oxygen tension regulate the Yersinia Ysc type III secretion system to enable disseminated infection

P. Kiley, G. Plano, Erin Mettert, 2019, PLoS pathogens.

Characterization of light-harvesting mutants of Rhodopseudomonas sphaeroides. I. Measurement of the efficiency of energy transfer from light-harvesting complexes to the reaction center.

A. Crofts, P. Kiley, S. Kaplan, 1985, Archives of biochemistry and biophysics.

Posttranscriptional control of puc operon expression of B800-850 light-harvesting complex formation in Rhodobacter sphaeroides

P. Kiley, J. K. Lee, S. Kaplan, 1989, Journal of bacteriology.

In vitro analysis of a constitutively active mutant form of the Escherichia coli global transcription factor FNR.

P. Kiley, E. Ziegelhoffer, 1995, Journal of molecular biology.

The transcription factor IscR promotes Yersinia type III secretion system activity by antagonizing the repressive H-NS-YmoA histone-like protein complex

P. Kiley, Erin Mettert, Victoria Auerbuch, 2021 .

Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specificity

P. Zwart, R. Brennan, P. Kiley, 2013, Nature Structural &Molecular Biology.

A Markerless Method for Genome Engineering in Zymomonas mobilis ZM4

P. Kiley, R. Landick, I. Ghosh, 2019, Front. Microbiol..

Transcriptome Changes Associated with Anaerobic Growth in Yersinia intermedia (ATCC29909)

J. Glasner, N. Perna, P. Kiley, 2013, PloS one.

The essential Rhodobacter sphaeroides CenKR two-component system regulates cell division and envelope biosynthesis

Kevin S. Myers, T. Donohue, P. Kiley, 2022, PLoS genetics.

Association of a polynuclear iron-sulfur center with a mutant FNR protein enhances DNA binding.

P. Kiley, H. Beinert, N. Khoroshilova, 1995, Proceedings of the National Academy of Sciences of the United States of America.

O2 availability impacts iron homeostasis in Escherichia coli

S. Keleş, P. Kiley, Erin L Mettert, 2017, Proceedings of the National Academy of Sciences.

Elevated Expression of a Functional Suf Pathway in Escherichia coli BL21(DE3) Enhances Recombinant Production of an Iron-Sulfur Cluster-Containing Protein

P. Kiley, E. Antony, Erin L Mettert, 2019, Journal of bacteriology.

Characterization of the [2Fe-2S] cluster of Escherichia coli transcription factor IscR.

J. Markley, A. Fleischhacker, P. Kiley, 2012, Biochemistry.

Repression by the H-NS/YmoA histone-like protein complex enables IscR dependent regulation of the Yersinia T3SS

P. Kiley, Victoria Auerbuch, Erin L Mettert, 2022, PLoS genetics.

Model-driven analysis of mutant fitness experiments improves genome-scale metabolic models of Zymomonas mobilis ZM4

Ramon Bonela Andrade, Brian F. Pfleger, J. Reed, 2020, PLoS Comput. Biol..

Defining bacterial regulons using ChIP-seq.

Kevin S. Myers, Dan M. Park, P. Kiley, 2015, Methods.

Characterization of the lipopolysaccharide from Actinobacillus actinomycetemcomitans Y4 and N27

P. Kiley, S. Holt, Patricia J. Kiley, 1980, Infection and immunity.

ArcA and AppY Antagonize IscR Repression of Hydrogenase-1 Expression under Anaerobic Conditions, Revealing a Novel Mode of O2 Regulation of Gene Expression in Escherichia coli

A. Fleischhacker, P. Kiley, A. D. Nesbit, 2012, Journal of bacteriology.

Elevated Expression of a Functional Suf Pathway in the E.coli BL21(DE3) Cell Line Enhances Recombinant Production of an Iron-Sulfur Cluster Containing Protein

P. Kiley, E. Antony, Erin L Mettert, 2019, bioRxiv.

Control of hmu Heme Uptake Genes in Yersinia pseudotuberculosis in Response to Iron Sources

P. Kiley, N. G. Herrera, Victoria Auerbuch, 2018, Front. Cell. Infect. Microbiol..

Physiological and structural analysis of light-harvesting mutants of Rhodobacter sphaeroides

P. Kiley, S. Kaplan, A. Varga, 1988, Journal of bacteriology.

Cloning, DNA Sequence, and Expression of the Rhodobacter sphaeroides Light-Harvesting B800-850-ct and B800-850-4 Genes

P. Kiley, S. Kaplan, 2022 .

Oxygen sensing by the global regulator, FNR: the role of the iron-sulfur cluster.

P. Kiley, H. Beinert, 1998, FEMS microbiology reviews.

Recombinant expression, purification, and kinetic characterization of chondroitinase AC and chondroitinase B from Flavobacterium heparinum.

P. Kiley, Z. Shriver, R. Sasisekharan, 2001, Biochemical and biophysical research communications.

IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins

P. Kiley, J. L. Giel, H. Beinert, 2001, Proceedings of the National Academy of Sciences of the United States of America.

The cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coli.

P. Kiley, J. Imlay, O. Djaman, 2000, Proceedings of the National Academy of Sciences of the United States of America.

The role of Fe-S proteins in sensing and regulation in bacteria.

P. Kiley, H. Beinert, 2003, Current opinion in microbiology.

Fe-S proteins that regulate gene expression.

P. Kiley, Erin L Mettert, 2015, Biochimica et biophysica acta.

Oxygen sensing by the global regulator, FNR: the role of the iron-sulfur cluster.

P. Kiley, H. Beinert, H Beinert, 1998, FEMS microbiology reviews.

Substitution of Leucine 28 with Histidine in theEscherichia coli Transcription Factor FNR Results in Increased Stability of the [4Fe-4S]2+ Cluster to Oxygen*

P. Kiley, H. Beinert, N. Khoroshilova, 2000, The Journal of Biological Chemistry.

Fe-S proteins in sensing and regulatory functions.

P. Kiley, H. Beinert, 1999, Current opinion in chemical biology.

Iron-sulfur cluster disassembly in the FNR protein of Escherichia coli by O2: [4Fe-4S] to [2Fe-2S] conversion with loss of biological activity.

P. Kiley, H. Beinert, N. Khoroshilova, 1997, Proceedings of the National Academy of Sciences of the United States of America.

A Diverged Transcriptional Network for Usage of Two Fe-S Cluster Biogenesis Machineries in the Delta-Proteobacterium Myxococcus xanthus

P. Kiley, B. Py, G. Brasseur, 2023, mBio.

How Is Fe-S Cluster Formation Regulated?

P. Kiley, Erin L Mettert, 2015, Annual review of microbiology.

Identification of a contact site for different transcription activators in region 4 of the Escherichia coli RNA polymerase sigma70 subunit.

C. Gross, S. Busby, M. Lonetto, 1998, Journal of molecular biology.

Minor Alterations in Core Promoter Element Positioning Reveal Functional Plasticity of a Bacterial Transcription Factor

K. Satyshur, J. Keck, P. Kiley, 2021, mBio.

Techniques to isolate O2-sensitive proteins: [4Fe-4S]-FNR as an example.

A. Yan, P. Kiley, 2009, Methods in enzymology.

Techniques to isolate O2-sensitive proteins: [4Fe-4S]-FNR as an example.

A. Yan, P. Kiley, 2009, Methods in enzymology.

Evolution of the metabolic and regulatory networks associated with oxygen availability in two phytopathogenic enterobacteria

J. Glasner, N. Perna, P. Kiley, 2012, BMC Genomics.

Redox control of gene expression involving iron‐sulfur proteins. Change of oxidation‐state or assembly/disassembly of Fe‐S clusters?

P. Kiley, H. Beinert, 1996, FEBS letters.

Regulated Stochasticity in a Bacterial Signaling Network Permits Tolerance to a Rapid Environmental Change

Kevin S. Myers, Jeffrey N. Carey, M. Goulian, 2018, Cell.

Regulated Stochasticity in a Bacterial Signaling NetworkPermits Tolerance to aRapidEnvironmental

Kevin S. Myers, M. Goulian, P. Kiley, 2018 .

Reconstruction of the Core and Extended Regulons of Global Transcription Factors

Timothy J. Donohue, Yann S. Dufour, T. Donohue, 2010, PLoS genetics.

IscR‐dependent gene expression links iron‐sulphur cluster assembly to the control of O2‐regulated genes in Escherichia coli

F. Blattner, D. Rodionov, P. Kiley, 2006, Molecular microbiology.

Genome Scale Analysis Reveals IscR Directly and Indirectly Regulates Virulence Factor Genes in Pathogenic Yersinia

P. Kiley, Rajdeep Banerjee, G. Saarunya, 2021, mBio.

Genome-scale Analysis of Escherichia coli FNR Reveals Complex Features of Transcription Factor Binding

Irene M. Ong, Dongjun Chung, Kevin S. Myers, 2013, PLoS genetics.

Phage integration alters the respiratory strategy of its host

Jeffrey N. Carey, M. Goulian, P. Kiley, 2019, eLife.

Characterization of FNR* mutant proteins indicates two distinct mechanisms for altering oxygen regulation of the Escherichia coli transcription factor FNR

P. Kiley, B. Lazazzera, D. Bates, 1995, Journal of bacteriology.

Fnr mutants that activate gene expression in the presence of oxygen

W. Reznikoff, P. Kiley, 1991, Journal of bacteriology.

Improving Mobilization of Foreign DNA into Zymomonas mobilis Strain ZM4 by Removal of Multiple Restriction Systems

Kevin S. Myers, P. Kiley, A. Guss, 2021, Applied and environmental microbiology.

Additional Determinants within Escherichia coli FNR Activating Region 1 and RNA Polymerase α Subunit Required for Transcription Activation

K. Weber, P. Kiley, Owen D. Vincent, 2005, Journal of bacteriology.

Techniques for studying the oxygen-sensitive transcription factor FNR from Escherichia coli.

Victoria R. Sutton, P. Kiley, Patricia J Kiley, 2003, Methods in enzymology.

Characterization of activating region 3 from Escherichia coli FNR.

K. Weber, P. Kiley, Christopher Luther, 2002, Journal of molecular biology.

FNR‐dependent activation of the class II dmsA and narG promoters of Escherichia coli requires FNR‐activating regions 1 and 3

P. Kiley, K. Lamberg, Patricia J. Kiley, 2000, Molecular microbiology.

The impact of O(2) on the Fe-S cluster biogenesis requirements of Escherichia coli FNR.

P. Kiley, F. W. Outten, Erin L Mettert, 2008, Journal of molecular biology.

Superoxide destroys the [2Fe-2S]2+ cluster of FNR from Escherichia coli.

Victoria R. Sutton, P. Kiley, H. Beinert, 2004, Biochemistry.

Genome-Wide Expression Analysis Indicates that FNR of Escherichia coli K-12 Regulates a Large Number of Genes of Unknown Function

Frederick R. Blattner, Yu Qiu, F. Blattner, 2005, Journal of bacteriology.

Global Responses of Bacteria to Oxygen Deprivation

T. Donohue, P. Kiley, 2011 .

Global Approaches for Finding Small RNA and Small Open Reading Frame Functions

K. Wassarman, P. Kiley, 2009, Journal of bacteriology.

The activity of the Escherichia coli transcription factor FNR is regulated by a change in oligomeric state.

P. Kiley, B. Lazazzera, D. Bates, 1993, Genes & development.

dPeak: High Resolution Identification of Transcription Factor Binding Sites from PET and SET ChIP-Seq Data

Sündüz Keleş, Dongjun Chung, Kevin S. Myers, 2013, PLoS Comput. Biol..

The puf operon region of Rhodobacter sphaeroides

T. Donohue, P. Kiley, S. Kaplan, 2004, Photosynthesis Research.

Regulation of iron–sulphur cluster homeostasis through transcriptional control of the Isc pathway by [2Fe–2S]–IscR in Escherichia coli

A. Fleischhacker, P. Kiley, A. D. Nesbit, 2013, Molecular microbiology.

Biochemical Characterization of the Chondroitinase B Active Site*

P. Kiley, R. Sasisekharan, R. Raman, 2002, The Journal of Biological Chemistry.

Impact of Anaerobiosis on Expression of the Iron-Responsive Fur and RyhB Regulons

Dongjun Chung, Kevin S. Myers, Sündüz Keleş, 2015, mBio.

Molecular genetics of photosynthetic membrane biosynthesis in Rhodobacter sphaeroides

P. Kiley, S. Kaplan, 1988 .

DNA sequence and in vitro expression of the B875 light-harvesting polypeptides of Rhodobacter sphaeroides

T. Donohue, P. Kiley, S. Kaplan, 1987, Journal of bacteriology.

Origin of the mRNA stoichiometry of the puf operon in Rhodobacter sphaeroides.

T. Donohue, P. Kiley, S. Kaplan, 1986, The Journal of biological chemistry.

IscR Is Essential for Yersinia pseudotuberculosis Type III Secretion and Virulence

Patricia P. Chan, T. Lowe, P. Kiley, 2014, PLoS pathogens.

Mössbauer spectroscopy as a tool for the study of activation/inactivation of the transcription regulator FNR in whole cells of Escherichia coli.

P. Kiley, H. Beinert, E. Münck, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Two‐pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration

D. Hassett, B. Gaston, H. Schweizer, 2007, The EMBO journal.

In Vitro Nitrate Reductase ) Operon Transcription ( Periplasmic napF K-12 Escherichia coli Fnr , NarP , and NarL Regulation of

P. Kiley, V. Stewart, E. Ziegelhoffer, 1998 .

Contributions of [4Fe-4S]-FNR and Integration Host Factor to fnr Transcriptional Regulation

P. Kiley, Erin L Mettert, 2007, Journal of bacteriology.

Aromatic inhibitors derived from ammonia-pretreated lignocellulose hinder bacterial ethanologenesis by activating regulatory circuits controlling inhibitor efflux and detoxification

Irene M. Ong, Sean McIlwain, Joonhoon Kim, 2014, Front. Microbiol..

Reassessing the Structure and Function Relationship of the O2 Sensing Transcription Factor FNR.

P. Kiley, Erin L Mettert, 2018, Antioxidants & redox signaling.

Identification and Unusual Properties of the Master Regulator FNR in the Extreme Acidophile Acidithiobacillus ferrooxidans

P. Kiley, D. Holmes, M. Dopson, 2019, Front. Microbiol..

Iron-containing transcription factors and their roles as sensors.

A. Fleischhacker, P. Kiley, 2011, Current opinion in chemical biology.

ClpXP-dependent proteolysis of FNR upon loss of its O2-sensing [4Fe-4S] cluster.

P. Kiley, Erin L Mettert, 2005, Journal of molecular biology.

Kinetic Analysis of the Oxidative Conversion of the [4Fe-4S]2+ Cluster of FNR to a [2Fe-2S]2+ Cluster

Victoria R. Sutton, P. Kiley, H. Beinert, 2004, Journal of bacteriology.

Regulation of FNR Dimerization by Subunit Charge Repulsion*

P. Kiley, Erin L Mettert, L. Moore, 2006, Journal of Biological Chemistry.

Dissecting the Role of the N-Terminal Region of the Escherichia coli Global Transcription Factor FNR

A. Yan, P. Kiley, 2008, Journal of bacteriology.

Characterization of the Dimerization Domain in the FNR Transcription Factor*

P. Kiley, L. Moore, 2001, The Journal of Biological Chemistry.

Reassessing the Structure and Function Relationship of the O2 Sensing Transcription Factor FNR.

P. Kiley, Erin L Mettert, L. MettertErin, 2017 .

Regulated Stochasticity in a Bacterial Signaling Network Permits Tolerance to a Rapid Environmental Change

Kevin S. Myers, Jeffrey N. Carey, M. Goulian, 2018, Cell.