O. Plotnikova

发表

Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation.

Roberto Sanchez, Ze'ev Ronai, Lei Zeng, 2004, Molecular cell.

Structural basis for the in vitro efficacy of nirmatrelvir against SARS-CoV-2 variants

K. Fennell, Wei Liu, O. Plotnikova, 2022, Journal of Biological Chemistry.

Structural basis for Nirmatrelvir in vitro efficacy against SARS-CoV-2 variants

K. Fennell, O. Plotnikova, C. Steppan, 2022, bioRxiv.

INPP5E interacts with AURKA, linking phosphoinositide signaling to primary cilium stability

O. Plotnikova, C. Mitchell, Seongjin Seo, 2015, Journal of Cell Science.

Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent.

Narendra Kumar Patel, Y. Liu, T. Mak, 2016, ACS medicinal chemistry letters.

The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents.

Narendra Kumar Patel, Y. Liu, T. Mak, 2015, Journal of medicinal chemistry.

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides.

Narendra Kumar Patel, T. Mak, N. Chirgadze, 2014, Bioorganic & medicinal chemistry.

The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.

Narendra Kumar Patel, T. Mak, N. Chirgadze, 2015 .

Primary cilia and the cell cycle.

E. Golemis, O. Plotnikova, E. Pugacheva, 2009, Methods in cell biology.

Rapid calcium-dependent activation of Aurora-A kinase

Roland L. Dunbrack, E. Golemis, O. Plotnikova, 2010, Nature communications.

Nedd9 restrains renal cystogenesis in Pkd1−/− mice

A. Klein-Szanto, A. Nikonova, B. Egleston, 2014, Proceedings of the National Academy of Sciences.

Inpp5e suppresses polycystic kidney disease via inhibition of PI3K/Akt-dependent mTORC1 signaling.

O. Plotnikova, R. Hobbs, C. Mitchell, 2016, Human molecular genetics.

Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation

Graham M. West, J. Culp, E. Carpenter, 2019, eLife.

The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents.

Y. Liu, T. Mak, P. Sampson, 2013, Journal of medicinal chemistry.

The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.

Narendra Kumar Patel, Y. Liu, T. Mak, 2015, Journal of medicinal chemistry.

Structural basis for the transport mechanism of the human glutamine transporter SLC1A5 (ASCT2)

Graham M. West, J. Culp, E. Carpenter, 2019, bioRxiv.

Phosphotyrosine Binding Domains of Shc and Insulin Receptor Substrate 1 Recognize the NPXpY Motif in a Thermodynamically Distinct Manner*

Ming-Ming Zhou, L. Zeng, O. Plotnikova, 1999, The Journal of Biological Chemistry.

Discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazin-8-yl)benzamides as novel, highly potent and selective, orally bioavailable inhibitors of Tyrosine Threonine Kinase, TTK.

Y. Liu, T. Mak, O. Plotnikova, 2016, Bioorganic & medicinal chemistry letters.

PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.

Roger M. Howard, S. Liras, K. Beaumont, 2020, Journal of medicinal chemistry.

Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis

Erica A. Golemis, A. Nikonova, E. Golemis, 2012, Molecular biology of the cell.

Aurora A kinase activity influences calcium signaling in kidney cells

E. Golemis, O. Plotnikova, 2011, Journal of Cell Biology.

Mutational remodeling of di-aspartyl intramembrane proteases : uncoupling physiologically-relevant activities from those associated with Alzheimer ' s disease

E. Rogaev, I. Bezprozvanny, O. Plotnikova, 2018 .

Mutational re-modeling of di-aspartyl intramembrane proteases: uncoupling physiologically-relevant activities from those associated with Alzheimer's disease.

E. Rogaev, I. Bezprozvanny, O. Plotnikova, 2017, Oncotarget.

T2384, a Novel Antidiabetic Agent with Unique Peroxisome Proliferator-activated Receptor γ Binding Properties*

M. Lindstrom, Xiaohong Liu, N. Walker, 2008, Journal of Biological Chemistry.

Structural basis of SNT PTB domain interactions with distinct neurotrophic receptors.

Ming-Ming Zhou, S. Mujtaba, L. Zeng, 2000, Molecular cell.

NEDD9 promotes oncogenic signaling in mammary tumor development.

M. Wolfson, R. Hardy, B. Egleston, 2009, Cancer research.

Conversion and compensatory evolution of the gamma-crystallin genes and identification of a cataractogenic mutation that reverses the sequence of the human CRYGD gene to an ancestral state.

E. Rogaev, P. Vlasov, F. Kondrashov, 2007, American journal of human genetics.

Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.

Alexey Bochkarev, Wolfram Tempel, Anne Mulichak, 2007, Molecular and biochemical parasitology.

The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.

Narendra Kumar Patel, Y. Liu, T. Mak, 2015, Journal of medicinal chemistry.

Cell cycle-dependent ciliogenesis and cancer.

E. Golemis, O. Plotnikova, E. Pugacheva, 2008, Cancer research.

Solution structure of the MAPK phosphatase PAC-1 catalytic domain. Insights into substrate-induced enzymatic activation of MKP.

Ming-Ming Zhou, L. Zeng, Sherry Yan, 2003, Structure.

Solution structure of ERK2 binding domain of MAPK phosphatase MKP-3: structural insights into MKP-3 activation by ERK2.

Ming-Ming Zhou, S. Mujtaba, L. Zeng, 2001, Molecular cell.

Structural insights into human KAP1 PHD finger–bromodomain and its role in gene silencing

Ming-Ming Zhou, K. Yap, A. Ivanov, 2008, Nature Structural &Molecular Biology.

Structure of the Nuclear Factor κB-inducing Kinase (NIK) Kinase Domain Reveals a Constitutively Active Conformation

N. Walker, Z. Cao, O. Plotnikova, 2012, The Journal of Biological Chemistry.

Inhibiting NF-κB-inducing kinase (NIK): discovery, structure-based design, synthesis, structure-activity relationship, and co-crystal structures.

O. Plotnikova, Zhulun Wang, Jinsong Liu, 2013, Bioorganic & medicinal chemistry letters.

A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3

Ming-Ming Zhou, L. Zeng, O. Plotnikova, 2003, Nature Structural Biology.

Solution Structure of ERK 2 Binding Domain of MAPK Phosphatase MKP-3 : Structural Insights into MKP-3 Activation

Ming-Ming Zhou, S. Mujtaba, O. Plotnikova, 2001 .

Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay

D. Lin, Hong Wang, J. Culp, 2017, PloS one.

Letter to the Editor: 1H, 13C and 15N resonance assignments of the SNT PTB domain in complex with FGFR1 peptide

Ming-Ming Zhou, L. Zeng, O. Plotnikova, 2000, Journal of biomolecular NMR.

Cell cycle-dependent ciliogenesis and cancer.

E. Golemis, O. Plotnikova, E. Pugacheva, 2008, Cancer research.

The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent.

Narendra Kumar Patel, Y. Liu, T. Mak, 2015, Journal of medicinal chemistry.