J. Frederick

发表

Smads "freeze" when they ski.

Xiao-Fan Wang, J. Frederick, 2002, Structure.

Further Characterization Of The Nodamura Virus Rna2 3'-Terminal Stem Loop Structure And Its Role In Viral Rna Replication

J. Frederick, 2012 .

A phase I multicenter study to assess the safety, tolerability, and immunogenicity of mRNA-4157 alone in patients with resected solid tumors and in combination with pembrolizumab in patients with unresectable solid tumors.

Manish R. Patel, H. Burris, J. Frederick, 2019, Journal of Clinical Oncology.

Transforming Growth Factor -Mediated Transcriptional Repression of c-myc Is Dependent on Direct Binding of Smad3 to a Novel Repressive Smad Binding Element

Yigong Shi, Xiao-Fan Wang, J. Frederick, 2004 .

Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction

X. F. Wang, M. Datto, J. Frederick, 1999, Molecular and Cellular Biology.

An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production.

B. Hogan, J. York, J. Frederick, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Casein Kinase Iϵ Plays a Functional Role in the Transforming Growth Factor-β Signaling Pathway*

Xiao-Fan Wang, J. Frederick, N. Liberati, 2004, Journal of Biological Chemistry.

A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation

J. York, R. Irving, J. Frederick, 2008, Proceedings of the National Academy of Sciences.

Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling.

Xiao-Fan Wang, R. Lefkowitz, G. Blobe, 2003, Science.

Role for cytoplasmic nucleotide hydrolysis in hepatic function and protein synthesis

J. York, R. Irving, J. Frederick, 2013, Proceedings of the National Academy of Sciences.

Essential Role for Smad3 in Regulating MCP-1 Expression and Vascular Inflammation

Richard N. Mitchell, Peter Libby, P. Libby, 2004, Circulation research.

Impaired Immune Responses and B-Cell Proliferation in Mice Lacking the Id3 Gene

J. Frederick, Y. Zhuang, S. Sato, 1999, Molecular and Cellular Biology.

A phase 1, open-label, multicenter study to assess the safety, tolerability, and immunogenicity of mRNA-4157 alone in subjects with resected solid tumors and in combination with pembrolizumab in subjects with unresectable solid tumors (Keynote-603).

J. Frederick, D. Cho, T. Zaks, 2019, Journal of Global Oncology.

The role of Smad3 in mediating mouse hepatic stellate cell activation

D. Brenner, Xiao-Fan Wang, J. Frederick, 2001, Hepatology.

Smads bind directly to the Jun family of AP-1 transcription factors.

Xing Shen, X. Shen, X. F. Wang, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Smad3-Smad4 and AP-1 Complexes Synergize in Transcriptional Activation of the c-Jun Promoter by Transforming Growth Factor β

Jian-ming Li, Xiao-Fan Wang, M. Datto, 1999, Molecular and Cellular Biology.

Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice.

D. Warburton, Xiao-Fan Wang, M. Datto, 2002, American journal of physiology. Lung cellular and molecular physiology.

Transforming Growth Factor (cid:2) -Mediated Transcriptional Repression of c- myc Is Dependent on Direct Binding of Smad3 to a Novel Repressive Smad Binding Element

Yigong Shi, Xiao-Fan Wang, J. Frederick, 2022 .

TGF-beta-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein.

Xing Shen, P. P. Hu, Xiao-Fan Wang, 1998, Molecular biology of the cell.

Smad 3-Smad 4 and AP-1 Complexes Synergize in Transcriptional Activation of the c-Jun Promoter by Transforming Growth Factor b

Jian-ming Li, Xiao-Fan Wang, M. Datto, 1999 .

Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction

X. F. Wang, M. Datto, J. Frederick, 1999, Molecular and Cellular Biology.

Tumor suppressor Smad4 is a transforming growth factor beta-inducible DNA binding protein

Xiao-Fan Wang, X. F. Wang, M. Datto, 1997, Molecular and cellular biology.

Smad 3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

D. Warburton, Xiao-Fan Wang, M. Datto, 2002 .

Functional Analysis of SMAD Activation in TGF-B-mediated Negative Growth Control in Breast Epithelial Cells

Xiao-Fan Wang, J. Frederick, 1999 .

798 Safety, tolerability, and immunogenicity of mRNA-4157 in combination with pembrolizumab in subjects with unresectable solid tumors (KEYNOTE-603): an update

J. Bauman, H. Burris, J. Frederick, 2020 .

Intratumoral IL12 mRNA Therapy Promotes TH1 Transformation of the Tumor Microenvironment

J. Lapointe, J. Frederick, R. Wilkinson, 2020, Clinical Cancer Research.

Durable anticancer immunity from intratumoral administration of IL-23, IL-36γ, and OX40L mRNAs

K. Burke, J. Frederick, Kana Ichikawa, 2019, Science Translational Medicine.

ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling

Xiao-Fan Wang, R. Lefkowitz, G. Blobe, 2003, Science.

The Loss of Smad3 Results in a Lower Rate of Bone Formation and Osteopenia Through Dysregulation of Osteoblast Differentiation and Apoptosis

Xiao-Fan Wang, M. Datto, J. Frederick, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Spatial Mapping and Immunomodulatory Role of the OX40/OX40L Pathway in Human Non–Small Cell Lung Cancer

K. Schalper, J. Frederick, R. Meehan, 2021, Clinical Cancer Research.

A phase I study of mRNA-2752, a lipid nanoparticle encapsulating mRNAs encoding human OX40L, IL-23, and IL-36γ, for intratumoral (iTu) injection alone and in combination with durvalumab.

R. Sullivan, A. Jimeno, P. LoRusso, 2020 .

Roles for inositol polyphosphate kinases in the regulation of nuclear processes and developmental biology.

J. York, A. Seeds, J. Frederick, 2007, Advances in enzyme regulation.

Transforming Growth Factor- (cid:1) 1 Inhibition of Vascular Smooth Muscle Cell Activation Is Mediated via Smad3*

Xiao-Fan Wang, V. Sukhatme, J. Frederick, 2022 .

Casein kinase Iepsilon plays a functional role in the transforming growth factor-beta signaling pathway.

Xiao-Fan Wang, J. Frederick, N. Liberati, 2004, The Journal of biological chemistry.

Transforming Growth Factor -Mediated Transcriptional Repression of c-myc Is Dependent on Direct Binding of Smad3 to a Novel Repressive Smad Binding Element

Yigong Shi, J. Frederick, N. Liberati, 2004 .

Abstract CT210: A Phase I, open-label, multicenter, dose escalation study of mRNA-2752, a lipid nanoparticle encapsulating mRNAs encoding human OX40L, IL-23, and IL-36γ, for intratumoral injection alone and in combination with immune checkpoint blockade

A. Jimeno, J. Frederick, T. Zaks, 2019, Clinical Trials.

Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element.

Yigong Shi, J. Frederick, N. Liberati, 2004, Molecular and cellular biology.

Transforming Growth Factor-β1 Inhibition of Vascular Smooth Muscle Cell Activation Is Mediated via Smad3*

V. Sukhatme, J. Frederick, T. Mammoto, 2004, Journal of Biological Chemistry.

767 Safety and preliminary efficacy of mRNA-2752, a lipid nanoparticle encapsulating mRNAs encoding human OX40L/IL-23/IL-36γ for intratumoral (ITu) injection, and durvalumab (IV) in TNBC, HNSCC, and melanoma

A. Jimeno, J. Frederick, S. Kummar, 2022, Regular and Young Investigator Award Abstracts.