M. D. de Caestecker

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The Smad4 Activation Domain (SAD) Is a Proline-rich, p300-dependent Transcriptional Activation Domain*

T. Shioda, A. Roberts, D. Wang, 2000, The Journal of Biological Chemistry.

Structural basis of Smad1 activation by receptor kinase phosphorylation.

J J Correia, Benoy M. Chacko, B. Qin, 2001, Molecular cell.

Fate mapping using Cited1-CreERT2 mice demonstrates that the cap mesenchyme contains self-renewing progenitor cells and gives rise exclusively to nephronic epithelia.

M. D. de Caestecker, H. Baldwin, Kelly J. Chandler, 2008, Developmental biology.

The transforming growth factor-beta/SMAD signaling pathway is present and functional in human mesangial cells.

H. Schnaper, M. D. de Caestecker, A. Poncelet, 1999, Kidney international.

Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases.

A. Roberts, R. Lechleider, M. D. de Caestecker, 1998, Genes & development.

Ischemia-reperfusion injury of the mouse kidney.

M. D. de Caestecker, Leif Oxburgh, 2012, Methods in molecular biology.

Ischemia-reperfusion model of acute kidney injury and post injury fibrosis in mice.

M. D. de Caestecker, R. Harris, N. Skrypnyk, 2013, Journal of visualized experiments : JoVE.

Experimental models of acute kidney injury for translational research

N. Hukriede, M. D. de Caestecker, S. Faubel, 2022, Nature Reviews Nephrology.

Histone deacetylase inhibitor enhances recovery after AKI.

N. Hukriede, M. D. de Caestecker, R. Harris, 2013, Journal of the American Society of Nephrology : JASN.

Retinoic Acid Signaling Coordinates Macrophage-Dependent Injury and Repair after AKI.

N. Hukriede, M. D. de Caestecker, R. Harris, 2016, Journal of the American Society of Nephrology : JASN.

Role of transforming growth factor-beta signaling in cancer.

A. Roberts, M. D. de Caestecker, E. Piek, 2000, Journal of the National Cancer Institute.

Molecular characterization of Wilms' tumor from a resource‐constrained region of sub‐Saharan Africa

R. Caprioli, M. D. de Caestecker, J. Pierce, 2012, International journal of cancer.

SIX2 and CITED1, markers of nephronic progenitor self-renewal, remain active in primitive elements of Wilms' tumor.

James R. Anderson, M. D. de Caestecker, A. Perantoni, 2012, Journal of pediatric surgery.

Cited1 is a bifunctional transcriptional cofactor that regulates early nephronic patterning.

S. Dunwoodie, I. Dawid, G. Shi, 2005, Journal of the American Society of Nephrology : JASN.

CITED1 expression in Wilms' tumor and embryonic kidney.

James R. Anderson, G. Shi, M. D. de Caestecker, 2007, Neoplasia.

Zebrafish kidney development: basic science to translational research.

N. Hukriede, M. D. de Caestecker, A. Davidson, 2011, Birth defects research. Part C, Embryo today : reviews.

Increased susceptibility to hypoxic pulmonary hypertension in Bmpr2 mutant mice is associated with endothelial dysfunction in the pulmonary vasculature.

M. D. de Caestecker, D. Frank, J. Reese, 2008, American journal of physiology. Lung cellular and molecular physiology.

Antagonism of the Thromboxane-Prostanoid Receptor is Cardioprotective against Right Ventricular Pressure Overload

M. D. de Caestecker, E. J. Carrier, A. Hemnes, 2016, Pulmonary circulation.

Overcoming Translational Barriers in Acute Kidney Injury: A Report from an NIDDK Workshop.

Jenna M. Norton, F. Harrell, J. Kaufman, 2018, Clinical journal of the American Society of Nephrology : CJASN.

Bmp2 and Bmp4 exert opposing effects in hypoxic pulmonary hypertension

M. D. de Caestecker, D. Mortlock, D. Frank, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

Structural basis of heteromeric smad protein assembly in TGF-beta signaling.

Benoy M. Chacko, B. Qin, S. Lam, 2004, Molecular cell.

Supervised deep generation of high-resolution arterial phase computed tomography kidney substructure atlas

Ho Hin Lee, Jeffery M. Spraggins, M. Heinrich, 2022, Medical Imaging.

BMPR2 mutations and endothelial dysfunction in pulmonary arterial hypertension (2017 Grover Conference Series)

M. D. de Caestecker, A. Frump, Allison R Prewitt, 2018, Pulmonary circulation.

Low-grade albuminuria in pulmonary arterial hypertension

M. D. de Caestecker, J. Cogan, J. Fessel, 2019, Pulmonary circulation.

Renal bone morphogenetic protein-7 protects against diabetic nephropathy.

M. D. de Caestecker, J. Lapage, J. Kopp, 2006, Journal of the American Society of Nephrology : JASN.

Atypical antiglomerular basement membrane disease associated with thin membrane nephropathy.

M. D. de Caestecker, C. L. Hall, A. Maciver, 1990, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Bridging Translation by Improving Preclinical Study Design in AKI.

F. Harrell, T. Nolin, M. D. de Caestecker, 2015, Journal of the American Society of Nephrology : JASN.

Bone Morphogenetic Protein 4 Promotes Pulmonary Vascular Remodeling in Hypoxic Pulmonary Hypertension

A. Pozzi, Y. Shyr, M. D. de Caestecker, 2005, Circulation research.

Translating Knowledge Into Therapy for Acute Kidney Injury.

M. D. de Caestecker, R. Harris, Raymond C. Harris, 2018, Seminars in nephrology.

KIDNEY REPAIR AND REGENERATION: PERSPECTIVES OF THE NIDDK (RE)BUILDING A KIDNEY CONSORTIUM.

C. Kesselman, J. Hubbell, N. Hukriede, 2022, Kidney international.

NFATc1 identifies a population of proximal tubule cell progenitors.

Bin Zhou, M. D. de Caestecker, H. Baldwin, 2009, Journal of the American Society of Nephrology : JASN.

Detection of abnormal peripheral blood mononuclear cell cytokine networks in human IgA nephropathy.

B. Telfer, M. Bottomley, M. D. de Caestecker, 1993, Kidney international.

The changing population on renal replacement therapy: its clinical and economic impact in Europe.

M. D. de Caestecker, N. Mallick, 1996, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Organ-specific defects in insulin-like growth factor and insulin receptor signaling in late gestational asymmetric intrauterine growth restriction in Cited1 mutant mice.

M. D. de Caestecker, M. Baserga, Tatiana Novitskaya, 2011, Endocrinology.

Cited1 and Cited2 are differentially expressed in the developing kidney but are not required for nephrogenesis

T. Shioda, M. D. de Caestecker, A. Perantoni, 2007, Developmental dynamics : an official publication of the American Association of Anatomists.

Heterozygous Null Bone Morphogenetic Protein Receptor Type 2 Mutations Promote SRC Kinase-dependent Caveolar Trafficking Defects and Endothelial Dysfunction in Pulmonary Arterial Hypertension*

A. Kenworthy, M. D. de Caestecker, A. Frump, 2014, The Journal of Biological Chemistry.

A PTBA small molecule enhances recovery and reduces postinjury fibrosis after aristolochic acid-induced kidney injury.

N. Hukriede, M. D. de Caestecker, L. Mcdermott, 2014, American journal of physiology. Renal physiology.

Placental insufficiency associated with loss of Cited1 causes renal medullary dysplasia.

S. Dunwoodie, M. D. de Caestecker, D. Sparrow, 2009, Journal of the American Society of Nephrology.

SIX2 Effects on Wilms Tumor Biology1

G. Ayers, M. D. de Caestecker, J. Pierce, 2014, Translational oncology.

Pyridoxamine reduces postinjury fibrosis and improves functional recovery after acute kidney injury.

M. D. de Caestecker, R. Harris, B. Hudson, 2016, American journal of physiology. Renal physiology.

Adapting decarbonylation chemistry for the development of prodrugs capable of in vivo delivery of carbon monoxide utilizing sweeteners as carrier molecules

M. D. de Caestecker, L. Otterbein, Binghe Wang, 2021, Chemical science.

Capillary rarefaction is more closely associated with CKD progression after cisplatin, rhabdomyolysis, and ischemia reperfusion-induced AKI than renal fibrosis.

M. D. de Caestecker, Anna Menshikh, Lauren Scarfe, 2019, American journal of physiology. Renal physiology.

Bridging translation for acute kidney injury with better preclinical modeling of human disease.

M. D. de Caestecker, S. Faubel, Leah J. Siskind, 2016, American journal of physiology. Renal physiology.

Modeling human disease: a mouse model of acute kidney injury to chronic kidney disease progression after cardiac arrest.

M. D. de Caestecker, A. Terker, 2020, Kidney international.

Long-term outcomes in mouse models of ischemia-reperfusion induced acute kidney injury.

M. D. de Caestecker, Anna Menshikh, Lauren Scarfe, 2019, American journal of physiology. Renal physiology.

Serotonin signaling in pulmonary hypertension.

M. D. de Caestecker, 2006, Circulation research.

Multiparametric MRI in Diagnosis of Long-term Renal Atrophy and Fibrosis after Ischemia Reperfusion Induced Acute Kidney Injury in Mice.

J. Gore, K. D. Harkins, M. D. de Caestecker, 2022, NMR in biomedicine.

Unexplained haematuria: Authors' reply

M. D. de Caestecker, F. Ballardie, 1991 .

Reply to “Bone morphogenetic protein's contribution to pulmonary artery hypertension”

M. D. de Caestecker, J. Lowery, T. King, 2016, Surgical neurology international.

Volumetric analysis of urinary erythrocytes: a standardized methodology to localize the source of haematuria.

M. D. de Caestecker, F. Ballardie, 1992, American journal of nephrology.

Angiopoietin-2 and glomerular proteinuria.

M. D. de Caestecker, 2007, Journal of the American Society of Nephrology.

Deletion of Fibroblast Growth Factor Receptor 2 from the Peri-Wolffian Duct Stroma Leads to Ureteric Induction Abnormalities and Vesicoureteral Reflux

M. D. de Caestecker, S. Sims-Lucas, C. Bates, 2013, PloS one.

The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis.

A. Roberts, Cecile Lee, Y. Shaul, 2001, Genes & development.

BMP signaling in vascular development and disease.

M. D. de Caestecker, J. Lowery, 2010, Cytokine & growth factor reviews.

Development and Stem Cells Research Article

M. D. de Caestecker, R. Friesel, Leif Oxburgh, 2022 .

DDR1 contributes to kidney inflammation and fibrosis by promoting the phosphorylation of BCR and STAT3

A. Pozzi, W. McDonald, M. D. de Caestecker, 2021, JCI insight.

The Extracellular Matrix Receptor Discoidin Domain Receptor 1 Regulates Collagen Transcription by Translocating to the Nucleus.

A. Pozzi, M. D. de Caestecker, A. Fogo, 2019, Journal of the American Society of Nephrology : JASN.

ID family protein expression and regulation in hypoxic pulmonary hypertension.

M. D. de Caestecker, A. Frump, J. Lowery, 2010, American journal of physiology. Regulatory, integrative and comparative physiology.

Aberrant activation, nuclear localization, and phosphorylation of yes‐associated protein‐1 in the embryonic kidney and Wilms tumor

James R. Anderson, M. D. de Caestecker, J. Dome, 2014, Pediatric blood & cancer.

Cell-free hemoglobin augments acute kidney injury during experimental sepsis.

M. D. de Caestecker, J. Bastarache, L. Ware, 2019, American journal of physiology. Renal physiology.

A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction.

A. Roberts, J. Martín, D. Wang, 2000, Genes & development.

The MSG1 Non-DNA-binding Transactivator Binds to the p300/CBP Coactivators, Enhancing Their Functional Link to the Smad Transcription Factors*

K. Isselbacher, A. Roberts, R. Lechleider, 2000, The Journal of Biological Chemistry.

Transcriptional activating activity of Smad4: roles of SMAD hetero-oligomerization and enhancement by an associating transactivator.

K. Isselbacher, T. Shioda, A. Roberts, 1998, Proceedings of the National Academy of Sciences of the United States of America.

SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta.

A. Roberts, J. Uitto, R. Lechleider, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Transcriptional Cross-talk between Smad, ERK1/2, and p38 Mitogen-activated Protein Kinase Pathways Regulates Transforming Growth Factor-β-induced Aggrecan Gene Expression in Chondrogenic ATDC5 Cells*

M. D. de Caestecker, Yoshihiko Yamada, H. Watanabe, 2001, The Journal of Biological Chemistry.

β-Catenin and K-RAS synergize to form primitive renal epithelial tumors with features of epithelial Wilms' tumors.

H. Moses, P. Clark, M. D. de Caestecker, 2011, The American journal of pathology.

Zebrafish nma is involved in TGFβ family signaling

A. Roberts, T. Kudoh, I. Dawid, 2000, Genesis.

The transforming growth factor-beta superfamily of receptors.

M. D. de Caestecker, Mark de Caestecker, 2004, Cytokine & growth factor reviews.

Role of transcriptional networks in coordinating early events during kidney development.

M. D. de Caestecker, S. Boyle, 2006, American journal of physiology. Renal physiology.

Delayed treatment with PTBA analogs reduces postinjury renal fibrosis after kidney injury.

D. Huryn, N. Hukriede, M. D. de Caestecker, 2016, American journal of physiology. Renal physiology.

Serine Phosphorylation, Chromosomal Localization, and Transforming Growth Factor-β Signal Transduction by Human bsp-1*

A. Dehejia, M. Polymeropoulos, A. Roberts, 1996, The Journal of Biological Chemistry.

HDAC inhibitors in kidney development and disease

N. Hukriede, M. D. de Caestecker, Lisa M. Swanhart, 2012, Pediatric Nephrology.

Carbon monoxide: An emerging therapy for acute kidney injury

M. D. de Caestecker, L. Otterbein, B. Wang, 2019, Medicinal research reviews.

Wilms' tumorigenesis is altered by misexpression of the transcriptional co-activator, CITED1.

Y. Shyr, G. Shi, M. D. de Caestecker, 2007, Journal of pediatric surgery.

Validation of HDAC8 Inhibitors as Drug Discovery Starting Points to Treat Acute Kidney Injury.

D. Huryn, N. Hukriede, M. D. de Caestecker, 2022, ACS pharmacology & translational science.

Sorting Nexin 6, a Novel SNX, Interacts with the Transforming Growth Factor-β Family of Receptor Serine-Threonine Kinases*

A. Roberts, J. McNally, C. Haft, 2001, The Journal of Biological Chemistry.

Characterization of Functional Domains within Smad4/DPC4*

A. Roberts, R. Lechleider, M. D. de Caestecker, 1997, The Journal of Biological Chemistry.

Localisation of haematuria by red cell analysers and phase contrast microscopy.

M. D. de Caestecker, J. Smith, C. L. Hall, 1989, Nephron.

Transdermal Measurement of Glomerular Filtration Rate in Mice

M. D. de Caestecker, P. Murray, Daniel Schock-Kusch, 2018, Journal of visualized experiments : JoVE.

The Transcriptional Activity of CITED1 Is Regulated by Phosphorylation in a Cell Cycle-dependent Manner*

S. Dunwoodie, G. Shi, M. D. de Caestecker, 2006, Journal of Biological Chemistry.

Abnormal Trafficking of Endogenously Expressed BMPR2 Mutant Allelic Products in Patients with Heritable Pulmonary Arterial Hypertension

M. D. de Caestecker, R. Hamid, A. Frump, 2013, PloS one.

A multiscale lipid and cellular atlas of the human kidney

Elizabeth K. Neumann, Lukasz G. Migas, R. Caprioli, 2022, bioRxiv.

CITED1 confers stemness to Wilms tumor and enhances tumorigenic responses when enriched in the nucleus

Andrew J. Murphy, Ethan Lee, Hernan Correa, 2013, Oncotarget.

Genotype-Phenotype Effects of Bmpr2 Mutations on Disease Severity in Mouse Models of Pulmonary Hypertension

M. D. de Caestecker, A. Frump, J. West, 2016, Pulmonary circulation.

The novel type I serine-threonine kinase receptor Alk8 binds TGF-beta in the presence of TGF-betaRII.

P. Yelick, A. Roberts, S. Bhattacharyya, 2002, Biochemical and biophysical research communications.

The detection of intracytoplasmic interleukin-1 alpha, interleukin-1 beta and tumour necrosis factor alpha expression in human monocytes using two colour immunofluorescence flow cytometry.

B. Telfer, M. D. de Caestecker, I. Hutchinson, 1992, Journal of immunological methods.

Inhibition of Retinoic Acid Signaling in Proximal Tubular Epithelial cells Protects against Acute Kidney Injury by Enhancing Kim-1-dependent Efferocytosis

M. D. de Caestecker, C. Brooks, A. Davidson, 2023, bioRxiv.

CITED1 expression in liver development and hepatoblastoma.

G. Ayers, M. D. de Caestecker, Zhiguo Zhao, 2012, Neoplasia.

Collection and Post-Surgical Excision of Human Kidney Tissue through the Cooperative Human Tissue Network v2

M. D. de Caestecker, A. Fogo, Jamie L Allen, 2021 .

Collection and Post-Surgical Excision of Human Kidney Tissue through the Cooperative Human Tissue Network v1

M. D. de Caestecker, A. Fogo, Jamie L Allen, 2019, protocols.io.

Drug Discovery to Halt the Progression of Acute Kidney Injury to Chronic Kidney Disease: A Case for Phenotypic Drug Discovery in Acute Kidney Injury

N. Hukriede, M. D. de Caestecker, A. Vogt, 2017, Nephron.

Sepsis-Associated Acute Kidney Injury: A Problem Deserving of New Solutions

J. Kellum, N. Hukriede, M. D. de Caestecker, 2019, Nephron.

Structural Basis of Heteromeric Smad Protein Assembly in TGF-β Signaling

Mark P. de Caestecker, Benoy M. Chacko, B. Qin, 2004 .

Renal cortex, medulla and pelvicaliceal system segmentation on arterial phase CT images with random patch-based networks

Shunxing Bao, Yuankai Huo, Bennett A. Landman, 2021, Medical Imaging.

The transforming growth factor-βbgr/SMAD signaling pathway is present and functional in human mesangial cells

H. Schnaper, M. Caestecker, M. D. de Caestecker, 1999 .

Deletion of Fibroblast Growth Factor Receptor 2 from the Peri-Wolffian Duct Stroma Leads to Ureteric Induction Abnormalities and Vesicoureteral Reflux

M. D. de Caestecker, S. Sims-Lucas, C. Bates, 2013, PloS one.

Autofluorescence microscopy as a label-free tool for renal histology and glomerular segmentation

Elizabeth K. Neumann, R. Caprioli, M. D. de Caestecker, 2021, bioRxiv.