R. Coulombe

发表

Conformation-based restrictions and scaffold replacements in the design of hepatitis C virus polymerase inhibitors: discovery of deleobuvir (BI 207127).

C. Brochu, S. LaPlante, M. Bös, 2014, Journal of medicinal chemistry.

Importance of ligand bioactive conformation in the discovery of potent indole-diamide inhibitors of the hepatitis C virus NS5B.

Araz Jakalian, Martin Poirier, C. Brochu, 2010, Journal of the American Chemical Society.

Crystal Structure of the E2 Transactivation Domain of Human Papillomavirus Type 11 Bound to a Protein Interaction Inhibitor*

Yong Wang, Louise Thauvette, C. Yoakim, 2004, Journal of Biological Chemistry.

Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors.

P. Bonneau, C. Yoakim, S. LaPlante, 2007, Bioorganic & medicinal chemistry letters.

Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.

R. Ménard, R. Coulombe, M. Cygler, 1996, The EMBO journal.

Compound aggregation in drug discovery: implementing a practical NMR assay for medicinal chemists.

P. Bonneau, S. LaPlante, R. Coulombe, 2013, Journal of medicinal chemistry.

Integrated strategies for identifying leads that target the NS3 helicase of the hepatitis C virus.

Araz Jakalian, Xiang Li, Steven R. LaPlante, 2014, Journal of medicinal chemistry.

Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor

J. Duan, M. Garneau, P. Bonneau, 2014, Antimicrobial Agents and Chemotherapy.

Molecular dynamics simulations and structure-based rational design lead to allosteric HCV NS5B polymerase thumb pocket 2 inhibitor with picomolar cellular replicon potency.

O. Hucke, P. Bonneau, C. Brochu, 2014, Journal of medicinal chemistry.

Thiotetrazole alkynylacetanilides as potent and bioavailable non-nucleoside inhibitors of the HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases.

J. Duan, M. Garneau, P. Bonneau, 2007, Bioorganic & medicinal chemistry letters.

N- versus O-alkylation: utilizing NMR methods to establish reliable primary structure determinations for drug discovery.

S. LaPlante, R. Coulombe, J. Gillard, 2013, Bioorganic & medicinal chemistry letters.

Crystal structure of the NADP+-dependent aldehyde dehydrogenase from Vibrio harveyi: structural implications for cofactor specificity and affinity.

M. Vedadi, R. Coulombe, E. Meighen, 2000, The Biochemical journal.

RAT PROCATHEPSIN B

R. Coulombe, M. Cygler, P. Grochulski, 1997 .

Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.

J. Duan, M. Garneau, C. Yoakim, 2014, ACS medicinal chemistry letters.

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.

O. Hucke, P. Bonneau, C. Yoakim, 2011, Bioorganic & medicinal chemistry letters.

Monitoring Binding of HIV‐1 Capsid Assembly Inhibitors Using 19F Ligand‐and 15N Protein‐Based NMR and X‐ray Crystallography: Early Hit Validation of a Benzodiazepine Series

Jean-François Mercier, Yves Bousquet, J. Mercier, 2013, ChemMedChem.

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

Wesley I. Sundquist, Stephen W. Mason, W. Sundquist, 2012, Journal of Virology.

N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies.

J. Duan, M. Garneau, C. Brochu, 2010, Bioorganic & medicinal chemistry letters.

Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases.

P. Bonneau, C. Yoakim, R. Coulombe, 2009, Bioorganic & medicinal chemistry letters.

The structure of L‐amino acid oxidase reveals the substrate trajectory into an enantiomerically conserved active site

R. Coulombe, S. Ghisla, P. Macheroux, 2000, The EMBO journal.

Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay.

M. Garneau, S. LaPlante, R. Coulombe, 2013, Bioorganic & medicinal chemistry letters.

Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype.

Araz Jakalian, Martin Poirier, Cédrickx Godbout, 2013, Bioorganic & medicinal chemistry letters.

Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.

Louise Thauvette, Araz Jakalian, M. Bös, 2013, Bioorganic & medicinal chemistry letters.

Structure of human procathepsin L reveals the molecular basis of inhibition by the prosegment.

R. Ménard, R. Coulombe, M. Cygler, 1996, The EMBO journal.

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.

Araz Jakalian, Sébastien Morin, Yves Bousquet, 2014, ACS medicinal chemistry letters.

Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion.

R. Coulombe, M. Cygler, P. Grochulski, 1996, Structure.

Inhibition of Ebola Virus by S-Adenosylhomocysteine Hydrolase Inhibitors

R. Coulombe, J. Huggins, Z. Zhang, 1995 .

Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.

J. Duan, M. Garneau, P. Bonneau, 2016, ACS medicinal chemistry letters.

Allosteric N-acetamide-indole-6-carboxylic acid thumb pocket 1 inhibitors of hepatitis C virus NS5B polymerase - Acylsulfonamides and acylsulfamides as carboxylic acid replacements

P. Kuhn, J. Duan, M. Garneau, 2013 .

Novel active site in Escherichia coli fructose 1,6-bisphosphate aldolase

R. Coulombe, J. Sygusch, N. Blom, 1996, Nature Structural Biology.

Crystal structure of two new bifunctional nonsubstrate type thrombin inhibitors complexed with human α‐thrombin

Y. Konishi, R. Coulombe, M. Cygler, 1996, Protein science : a publication of the Protein Society.

Crystallization and preliminary x‐ray diffraction studies of human procathepsin L

R. Ménard, R. Coulombe, M. Cygler, 1996, Proteins.

Oxygen Access to the Active Site of Cholesterol Oxidase through a Narrow Channel Is Gated by an Arg-Glu Pair*

R. Coulombe, S. Ghisla, A. Vrielink, 2001, The Journal of Biological Chemistry.

Structural basis for specificity of papain‐like cysteine protease proregions toward their cognate enzymes

J. Jenkins, R. Coulombe, M. Cygler, 1998, Proteins.

Enantiomeric atropisomers inhibit HCV polymerase and/or HIV matrix: characterizing hindered bond rotations and target selectivity.

O. Hucke, S. LaPlante, R. Coulombe, 2014, Journal of medicinal chemistry.

Structure-based design of novel HCV NS 5 B thumb pocket 2 allosteric inhibitors with submicromolar gt 1 replicon potency : Discovery of a

J. Duan, O. Hucke, R. Coulombe, 2013 .

Monitoring drug self-aggregation and potential for promiscuity in off-target in vitro pharmacology screens by a practical NMR strategy.

P. Bonneau, S. LaPlante, R. Coulombe, 2013, Journal of Medicinal Chemistry.