B. Thavonekham

发表

Conformation-based restrictions and scaffold replacements in the design of hepatitis C virus polymerase inhibitors: discovery of deleobuvir (BI 207127).

C. Brochu, S. LaPlante, M. Bös, 2014, Journal of medicinal chemistry.

Scaffold hopping in the rational design of novel HIV-1 non-nucleoside reverse transcriptase inhibitors.

P. Bonneau, C. Yoakim, S. LaPlante, 2007, Bioorganic & medicinal chemistry letters.

Novel small renin inhibitors containing 4,5- or 3,5-dihydroxy-2-substituted-6-phenylhexanamide replacements at the P2-P3 sites.

P. Anderson, B. Thavonekham, B. Simoneau, 1998, Bioorganic & medicinal chemistry.

Discovery of non-peptidic P2-P3 butanediamide renin inhibitors with high oral efficacy.

P. Anderson, C. Chabot, B. Thavonekham, 1999, Bioorganic & medicinal chemistry.

Novel nevirapine-like inhibitors with improved activity against NNRTI-resistant HIV: 8-heteroarylthiomethyldipyridodiazepinone derivatives.

J. Duan, P. Bonneau, C. Yoakim, 2004, Bioorganic & medicinal chemistry letters.

Discovery of BI 207524, an indole diamide NS5B thumb pocket 1 inhibitor with improved potency for the potential treatment of chronic hepatitis C virus infection.

J. Duan, M. Garneau, P. Anderson, 2014, Journal of medicinal chemistry.

Identification of potent and orally bioavailable nucleotide competing reverse transcriptase inhibitors: in vitro and in vivo optimization of a series of benzofurano[3,2-d]pyrimidin-2-one derived inhibitors.

J. Duan, M. Garneau, S. Morin, 2013, Bioorganic & medicinal chemistry letters.

N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies.

J. Duan, M. Garneau, C. Brochu, 2010, Bioorganic & medicinal chemistry letters.

Investigation on the role of the tetrazole in the binding of thiotetrazolylacetanilides with HIV-1 wild type and K103N/Y181C double mutant reverse transcriptases.

P. Bonneau, C. Yoakim, R. Coulombe, 2009, Bioorganic & medicinal chemistry letters.

A PRACTICAL SYNTHESIS OF UREAS FROM PHENYL CARBAMATES

B. Thavonekham, 1997 .

Removable Phosphine Reagents for the Mitsunobu Reaction

C. Yoakim, B. Thavonekham, Jeff O'meara, 2003 .

Multi-gram synthesis of a nucleotide-competing reverse transcriptase inhibitor

S. Morin, B. Thavonekham, Y. Bousquet, 2013 .

Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay.

M. Garneau, S. LaPlante, R. Coulombe, 2013, Bioorganic & medicinal chemistry letters.

Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype.

Araz Jakalian, Martin Poirier, Cédrickx Godbout, 2013, Bioorganic & medicinal chemistry letters.

Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.

Louise Thauvette, Araz Jakalian, M. Bös, 2013, Bioorganic & medicinal chemistry letters.

Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.

J. Duan, M. Garneau, P. Bonneau, 2016, ACS medicinal chemistry letters.

Allosteric N-acetamide-indole-6-carboxylic acid thumb pocket 1 inhibitors of hepatitis C virus NS5B polymerase - Acylsulfonamides and acylsulfamides as carboxylic acid replacements

P. Kuhn, J. Duan, M. Garneau, 2013 .

Novel 8-substituted dipyridodiazepinone inhibitors with a broad-spectrum of activity against HIV-1 strains resistant to non-nucleoside reverse transcriptase inhibitors.

J. Duan, M. Garneau, P. Bonneau, 2005, Journal of Medicinal Chemistry.

Structure-based design of novel HCV NS 5 B thumb pocket 2 allosteric inhibitors with submicromolar gt 1 replicon potency : Discovery of a

J. Duan, O. Hucke, R. Coulombe, 2013 .