A. Mould

发表

Disruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors.

M. Humphries, A. Mould, S. E. Craig, 2014, The Biochemical journal.

Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH‐terminal heparin‐binding domain of fibronectin.

M. Humphries, A. Mould, 1991, The EMBO journal.

Integrin alpha 4 beta 1-mediated melanoma cell adhesion and migration on vascular cell adhesion molecule-1 (VCAM-1) and the alternatively spliced IIICS region of fibronectin.

M. Humphries, A. Mould, S. E. Craig, 1994, The Journal of biological chemistry.

The Cell-binding Domain of Intimin from Enteropathogenic Escherichia coli Binds to β1 Integrins*

G. Dougan, M. Humphries, A. Mould, 1996, The Journal of Biological Chemistry.

Anti-integrin monoclonal antibodies

M. Humphries, A. Mould, S. E. Craig, 2009, Journal of Cell Science.

Structure of an Integrin-Ligand Complex Deduced from Solution X-ray Scattering and Site-directed Mutagenesis*

P. McEwan, M. Humphries, J. G. Grossmann, 2003, Journal of Biological Chemistry.

Pleomorphism in type I collagen fibrils produced by persistence of the procollagen N-propeptide.

J. A. Chapman, K. Kadler, A. Mould, 1989, Journal of molecular biology.

Enteric Species F Human Adenoviruses use Laminin-Binding Integrins as Co-Receptors for Infection of Ht-29 Cells

J. Heino, J. Gall, A. Mould, 2018, Scientific Reports.

Substratum-dependent stimulation of fibroblast migration by the gelatin-binding domain of fibronectin.

M. Humphries, A. Mould, D. Mosher, 1996, Journal of cell science.

Novel activating and inactivating mutations in the integrin beta1 subunit A domain.

M. Humphries, A. Mould, S. E. Craig, 2004, The Biochemical journal.

Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction?

M. Humphries, A. Mould, 2004, Current opinion in cell biology.

Procollagen Processing Control of Type I Collagen Fibril Assembly

J. A. Chapman, K. Kadler, A. Mould, 1989 .

Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin alpha5beta1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding.

M. Humphries, A. Mould, T. Jackson, 2000, The Journal of general virology.

The herpes viral transcription factor ICP4 forms a novel DNA recognition complex

A. Mould, T. Jowitt, Michael P. Lockhart-Cairns, 2017, Nucleic acids research.

Dynamic aspects of adhesion receptor function — integrins both twist and shout

M. Humphries, A. Mould, D. Tuckwell, 1993, BioEssays : news and reviews in molecular, cellular and developmental biology.

Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1.

M. Humphries, A. Mould, K. Yamada, 1990, The Journal of biological chemistry.

Integrin αvβ1 Is a Receptor for Foot-and-Mouth Disease Virus

D. Sheppard, A. Mould, T. Jackson, 2002, Journal of Virology.

Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding.

M. Humphries, A. Mould, K. Clark, 1999, The Biochemical journal.

Ligand-induced Epitope Masking

M. Humphries, A. Mould, T. Jowitt, 2016, The Journal of Biological Chemistry.

JCB_200810002 1275..1284

Andrés J. García, M. Humphries, A. Mould, 2009 .

Cell biology: Adhesion articulated

M. Humphries, A. Mould, 2004, Nature.

Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling

S. Holley, A. Mould, E. Koper, 2009, Development.

Distinct Roles of β1 Metal Ion-dependent Adhesion Site (MIDAS), Adjacent to MIDAS (ADMIDAS), and Ligand-associated Metal-binding Site (LIMBS) Cation-binding Sites in Ligand Recognition by Integrin α2β1*

M. Humphries, A. Mould, Dimitra Valdramidou, 2008, Journal of Biological Chemistry.

The "linker" region (amino acids 38-47) of the disintegrin elegantin is a novel inhibitory domain of integrin alpha5beta1-dependent cell adhesion on fibronectin: evidence for the negative regulation of fibronectin synergy site biological activity.

E. Wijelath, M. Humphries, A. Mould, 2006, The Journal of biological chemistry.

Evidence That Monoclonal Antibodies Directed against the Integrin β Subunit Plexin/Semaphorin/Integrin Domain Stimulate Function by Inducing Receptor Extension*

J. A. Hamilton, R. Kammerer, M. Humphries, 2005, Journal of Biological Chemistry.

Integrin Activation Involves a Conformational Change in the α1 Helix of the β Subunit A-domain*

P. McEwan, M. Humphries, A. Mould, 2002, The Journal of Biological Chemistry.

Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain.

P. McEwan, M. Humphries, A. Mould, 2002, The Journal of biological chemistry.

Molecular basis of ligand recognition by integrin alpha 5beta 1. I. Specificity of ligand binding is determined by amino acid sequences in the second and third NH2-terminal repeats of the alpha subunit.

M. Humphries, A. Mould, J. Askari, 2000, The Journal of biological chemistry.

Screen for multi-SUMO–binding proteins reveals a multi-SIM–binding mechanism for recruitment of the transcriptional regulator ZMYM2 to chromatin

A. Sharrocks, R. Hay, A. Mould, 2015, Proceedings of the National Academy of Sciences.

The CUB domains of procollagen C-proteinase enhancer control collagen assembly solely by their effect on procollagen C-proteinase/bone morphogenetic protein-1.

A. Mould, E. Kessler, D. Hulmes, 1997, Matrix biology : journal of the International Society for Matrix Biology.

GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation

M. Tassabehji, C. Biot, J. Thomas-Oates, 2019, Nature Communications.

Mechanisms of VCAM-1 and fibronectin binding to integrin alpha 4 beta 1: implications for integrin function and rational drug design.

M. Humphries, A. Mould, P. Newham, 1995, Ciba Foundation symposium.

Ligand-induced epitope masking. Dissociation of integrin 51-fibronectin complexes only by monoclonal antibodies with an allosteric mode of action.

M. Humphries, A. Mould, T. Jowitt, 2018 .

Evidence for the presence of a low-mass β1 integrin on the cell surface

W. Ens, K. Standing, M. Humphries, 2005, Journal of Cell Science.

A specific α5β1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation

Kenneth M. Yamada, M. Humphries, A. Mould, 2005, Journal of Cell Science.

without Affecting Protective Immunity Development of Murine Lyme Arthritis Antagonist Prevents 1 b 4 a A Small Molecule

G. Curley, M. Humphries, A. Mould, 2005 .

Conjugation of synthetic peptides to carrier proteins for cell adhesion studies

M. Humphries, A. Mould, S. Weston, 1994 .

Regulation of Integrin α5β1-Fibronectin Interactions by Divalent Cations

M. Humphries, A. Mould, S. Akiyama, 1995, The Journal of Biological Chemistry.

VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin

M. Humphries, A. Mould, C. Morimoto, 1990, The Journal of experimental medicine.

Getting integrins into shape: recent insights into how integrin activity is regulated by conformational changes.

A. Mould, 1996, Journal of cell science.

Analyzing Integrin‐Dependent Adhesion

A. Mould, 2018, Current protocols in cell biology.

Analyzing Integrin‐Dependent Adhesion

A. Mould, 2002, Current protocols in cell biology.

Analyzing Integrin‐Dependent Adhesion

A. Mould, 2002, Current protocols in cell biology.

An assessment of the efficacy of anti-integrin alpha subunit monoclonal antibody production using affinity purified beta 1-integrin dimers as immunogen.

M. Humphries, A. Mould, K. Yamada, 1991, Biochemical Society transactions.

Mica sandwich technique for preparing macromolecules for rotary shadowing.

J. A. Chapman, K. Kadler, A. Mould, 1985, Journal of ultrastructure research.

Procollagen type I C-proteinase enhancer is a naturally occurring connective tissue glycoprotein.

A. Mould, E. Kessler, D. Hulmes, 1990, Biochemical and biophysical research communications.

I. SPECIFICITY OF LIGAND BINDING IS DETERMINED BY AMINO ACID SEQUENCES IN THE SECOND AND THIRD NH2-TERMINAL REPEATS OF THE a SUBUNIT*

M. Humphries, A. Mould, J. Askari, 2000 .

Integrin (cid:2) v (cid:3) 1 Is a Receptor for Foot-and-Mouth Disease Virus

D. Sheppard, A. Mould, T. Jackson, 2001 .

Matrix Receptors in Cell Migration

Kenneth M. Yamada, M. Humphries, A. Mould, 1991 .

Demonstration of catch bonds between an integrin and its ligand

Andrés J. García, M. Humphries, A. Mould, 2009, The Journal of cell biology.

Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+.

M. Humphries, A. Mould, S. Akiyama, 1995, The Journal of biological chemistry.

Variant choriocarcinoma (BeWo) cells that differ in adhesion and migration on fibronectin display conserved patterns of integrin expression.

A. Mould, J. Aplin, A. Sattar, 1992, Journal of cell science.

The inhibitory anti-beta1 integrin monoclonal antibody 13 recognizes an epitope that is attenuated by ligand occupancy. Evidence for allosteric inhibition of integrin function.

M. Humphries, A. Mould, S. Akiyama, 1996, The Journal of biological chemistry.

Identification of a novel anti‐integrin monoclonal antibody that recognises a ligand‐induced binding site epitope on the β1 subunit

M. Humphries, A. Mould, A. Garratt, 1995, FEBS letters.

E-cadherin is a ligand for integrin α2β1

O. Pertz, J. Engel, M. Humphries, 2002 .

Surface-induced aggregation of type I procollagen.

A. Mould, D. Hulmes, 1987, Journal of molecular biology.

The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues.

M. Humphries, A. Mould, K. Yamada, 1991, The Journal of biological chemistry.

Morphology of sheet-like assemblies of pN-collagen, pC-collagen and procollagen studied by scanning transmission electron microscopy mass measurements.

J. A. Chapman, A. Mould, D. Holmes, 1991, Journal of molecular biology.

D-periodic assemblies of type I procollagen.

J. A. Chapman, A. Mould, D. Hulmes, 1990, Journal of molecular biology.

Linking integrin conformation to function

M. Humphries, A. Mould, P. Buckley, 2009, Journal of Cell Science.

Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach.

Adam Byron, M. Humphries, A. Mould, 2009, The Biochemical journal.

Molecular Mechanism of SR Protein Kinase 1 Inhibition by the Herpes Virus Protein ICP27

A. Mould, R. Sandri-Goldin, C. Levy, 2019, mBio.

Defining the topology of integrin alpha5beta1-fibronectin interactions using inhibitory anti-alpha5 and anti-beta1 monoclonal antibodies. Evidence that the synergy sequence of fibronectin is recognized by the amino-terminal repeats of the alpha5 subunit.

S. Aota, M. Humphries, A. Mould, 1997, The Journal of biological chemistry.

Structural Basis for Specific Interaction of TGFβ Signaling Regulators SARA/Endofin with HD-PTP

L. Tabernero, A. Mould, P. Woodman, 2017, Structure.

Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1.

M. Humphries, A. Mould, Y. Takada, 1998, The Biochemical journal.

Identification of multiple integrin β1 homologs in zebrafish (Danio rerio)

J. Huxley-Jones, R. Boot-Handford, M. Humphries, 2006, BMC Cell Biology.

Chimeric hepatitis B virus core particles as probes for studying peptide-integrin interactions

G. Dougan, B. Clarke, M. Francis, 1996, Journal of virology.

Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis

H. van Marwijk, L. Riste, A. Mould, 2019, BMC Medicine.

Mechanisms of integration of cells and extracellular matrices by integrins.

M. Humphries, A. Mould, M. Travis, 2004, Biochemical Society transactions.

GORAB scaffolds COPI at the trans-Golgi for efficient enzyme recycling and correct protein glycosylation

M. Tassabehji, C. Biot, J. Thomas-Oates, 2019, Nature Communications.

The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function

L. Tabernero, A. Mould, T. Jowitt, 2017, Scientific Reports.

Expression and characterisation of a very-late antigen-4 (alpha 4 beta 1) integrin-binding fragment of vascular cell-adhesion molecule-1.

M. Humphries, A. Mould, P. Driscoll, 1994, European journal of biochemistry.

Dual Functionality of the Anti-β1 Integrin Antibody, 12G10, Exemplifies Agonistic Signalling from the Ligand Binding Pocket of Integrin Adhesion Receptors*

M. Humphries, A. Mould, A. Garratt, 2005, Journal of Biological Chemistry.

Defining the Topology of Integrin α5β1-Fibronectin Interactions Using Inhibitory Anti-α5 and Anti-β1 Monoclonal Antibodies

S. Aota, M. Humphries, A. Mould, 1997, The Journal of Biological Chemistry.

Cyclic mechanical reinforcement of integrin-ligand interactions.

Andrés J. García, M. Humphries, A. Mould, 2013, Molecular cell.

Errata to Cyclic mechanical reinforcement of integrin-ligand interactions [Molecular Cell 49, (2013) 1060-1068]

Andrés J. García, M. Humphries, A. Mould, 2013 .

Conformational Changes in the Integrin βA Domain Provide a Mechanism for Signal Transduction via Hybrid Domain Movement*

P. McEwan, M. Humphries, A. Mould, 2003, The Journal of Biological Chemistry.

A Small Molecule α4β1 Antagonist Prevents Development of Murine Lyme Arthritis without Affecting Protective Immunity1

G. Curley, M. Humphries, A. Mould, 2005, The Journal of Immunology.

Analysis of ligand-induced and ligand-attenuated epitopes on the leukocyte integrin alpha4beta1: VCAM-1, mucosal addressin cell adhesion molecule-1, and fibronectin induce distinct conformational changes.

M. Humphries, A. Mould, S. E. Craig, 1998, Journal of immunology.

The open architecture of HD-PTP phosphatase provides new insights into the mechanism of regulation of ESCRT function

L. Tabernero, A. Mould, T. Jowitt, 2017, Scientific Reports.

The Collagens of Hydra Provide Insight into the Evolution of Metazoan Extracellular Matrices*

David L. Robertson, Julie Huxley-Jones, J. Huxley-Jones, 2007, Journal of Biological Chemistry.

The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family

J. Huxley-Jones, D. Robertson, R. Boot-Handford, 2005, BMC Evolutionary Biology.

A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.

Kenneth M. Yamada, M. Humphries, A. Mould, 2005, Journal of cell science.

The integrin beta subunit.

A. Mould, L. J. Green, M. Humphries, 1998, The international journal of biochemistry & cell biology.

Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble.

P. McEwan, M. Humphries, A. Mould, 2003, Trends in biochemical sciences.

An Anthropomorphic Integrin

M. Humphries, A. Mould, 2001, Science.

Molecular Basis of Ligand Recognition by Integrin α5β1

M. Humphries, A. Mould, J. Askari, 2000, The Journal of Biological Chemistry.

JCB_200810002 1275..1284

Cheng Zhu, Andrés J. García, M. Humphries, 2009 .

Identification of Amino Acid Residues That Form Part of the Ligand-binding Pocket of Integrin α5β1 *

M. Humphries, A. Mould, L. Burrows, 1998, The Journal of Biological Chemistry.

Mapping functional residues onto integrin crystal structures.

M. Humphries, A. Mould, E. Symonds, 2003, Current opinion in structural biology.

Molecular Basis of Ligand Recognition by Integrin α5β1

M. Humphries, A. Mould, J. Askari, 2000, The Journal of Biological Chemistry.

Role of ADMIDAS Cation-binding Site in Ligand Recognition by Integrin α5β1*

M. Humphries, A. Mould, S. E. Craig, 2003, Journal of Biological Chemistry.

Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1.

M. Humphries, A. Mould, S. E. Craig, 2003, The Journal of biological chemistry.

Solid phase assays for studying ECM protein-protein interactions.

A. Mould, Paul Mould, 2009, Methods in molecular biology.

Molecular basis of ligand recognition by integrin alpha5beta 1. II. Specificity of arg-gly-Asp binding is determined by Trp157 OF THE alpha subunit.

M. Humphries, A. Mould, Y. Takada, 2000, The Journal of biological chemistry.

Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1.

M. Humphries, A. Mould, J. Clements, 1994, The Journal of biological chemistry.

E-cadherin is a ligand for integrin alpha2beta1.

O. Pertz, J. Engel, M. Humphries, 2002, Matrix biology : journal of the International Society for Matrix Biology.

The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family

J. Huxley-Jones, A. Mould, R. Ewan, 2005, BMC Evolutionary Biology.