Gerdien E. de Kloe

发表

Interaction kinetic and structural dynamic analysis of ligand binding to acetylcholine-binding protein.

I. D. de Esch, A. Smit, U. H. Danielson, 2010, Biochemistry.

Small and colorful stones make beautiful mosaics: fragment-based chemogenomics.

Saskia Nijmeijer, Chris de Graaf, Rob Leurs, 2013, Drug Discovery Today.

Small and Colorful Tesserae Make Beautiful Mosaics: Fragment‐based Chemogenomics Introduction

I. D. de Esch, R. Leurs, C. de Graaf, 2022 .

Development of a microfluidic confocal fluorescence detection system for the hyphenation of nano-LC to on-line biochemical assays

Henk Lingeman, August B. Smit, Jeroen Kool, 2010, Analytical and bioanalytical chemistry.

Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H4 and the ion channel serotonin 5-HT3A

R. Smits, I. D. de Esch, O. Zuiderveld, 2011, Bioorganic & medicinal chemistry letters.

Triazole ligands reveal distinct molecular features that induce histamine H4 receptor affinity and subtly govern H4/H3 subtype selectivity.

Saskia Nijmeijer, Chris de Graaf, Rob Leurs, 2011, Journal of medicinal chemistry.

High-Resolution Bioactivity Profiling of Mixtures toward the Acetylcholine Binding Protein Using a Nanofractionation Spotter Technology

Rob Leurs, Henk Lingeman, Ewald Edink, 2011, Journal of biomolecular screening.

Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands.

I. D. de Esch, R. Leurs, A. Smit, 2010, Journal of medicinal chemistry.

Transforming fragments into candidates: small becomes big in medicinal chemistry.

Rob Leurs, Gerdien E de Kloe, David Bailey, 2009, Drug discovery today.

Assembly of a π–π stack of ligands in the binding site of an acetylcholine-binding protein

August B. Smit, Titia K. Sixma, Alexander Fish, 2013, Nature Communications.

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease

B. de Strooper, Gerdien E. de Kloe, S. Munck, 2012, Nature Medicine.

Online fluorescence enhancement assay for the acetylcholine binding protein with parallel mass spectrometric identification.

I. D. de Esch, R. Leurs, A. Smit, 2010, Journal of medicinal chemistry.

Nanofractionation spotter technology for rapid contactless and high-resolution deposition of LC eluent for further off-line analysis.

I. D. de Esch, R. Leurs, A. Smit, 2011, Analytical chemistry.