D. Schlaepfer

发表

Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation.

Susan J Fisher, S. Fisher, S. Lim, 2008, Molecular cell.

FAK in cancer: mechanistic findings and clinical applications

D. Schlaepfer, Florian J. Sulzmaier, C. Jean, 2014, Nature Reviews Cancer.

Focal Adhesion Kinase Overexpression Enhances Ras-dependent Integrin Signaling to ERK2/Mitogen-activated Protein Kinase through Interactions with and Activation of c-Src*

T. Hunter, D. Schlaepfer, 1997, The Journal of Biological Chemistry.

Focal adhesion kinase: in command and control of cell motility

D. A. Hanson, D. Schlaepfer, S. Mitra, 2005, Nature Reviews Molecular Cell Biology.

FAK / PYK 2 promotes the Wnt / β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK 3 β

D. Schlaepfer, Jing Hu, Chenxi Gao, 2015 .

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

Erin Rericha, I. Schneider, D. Schlaepfer, 2010, The Journal of cell biology.

Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration.

D. Schlaepfer, C. Hauck, D. Sieg, 1999, Journal of cell science.

Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility.

D. Schlaepfer, Alok Tomar, David D Schlaepfer, 2009, Current opinion in cell biology.

Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation*

S. Lim, Xiao Lei Chen, D. Schlaepfer, 2010, The Journal of Biological Chemistry.

Control of motile and invasive cell phenotypes by focal adhesion kinase.

D. Schlaepfer, D. Ilić, S. Mitra, 2004, Biochimica et biophysica acta.

Multiple Grb2-Mediated Integrin-Stimulated Signaling Pathways to ERK2/Mitogen-Activated Protein Kinase: Summation of Both c-Src- and Focal Adhesion Kinase-Initiated Tyrosine Phosphorylation Events

Tony Hunter, T. Hunter, D. Schlaepfer, 1998, Molecular and Cellular Biology.

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular-fibrosis and tumor progression

Christine A Iacobuzio-Donahue, Kirk Hansen, Raghu Kalluri, 2016, Nature Medicine.

Distinct FAK-Src activation events promote α5β1 and α4β1 integrin-stimulated neuroblastoma cell motility

S. Lim, D. Schlaepfer, D. Mikolon, 2008, Oncogene.

Integrin (cid:2) 4 (cid:3) 1 Promotes Focal Adhesion Kinase-Independent Cell Motility via (cid:2) 4 Cytoplasmic Domain-Speciﬁc Activation of c-Src‡

Sakae Tanaka, S. Lim, D. Schlaepfer, 2022 .

Distinct cellular expression pattern of annexins in Hydra vulgaris

H. Bode, D. Schlaepfer, H. Haigler, 1992, The Journal of cell biology.

Differential regulation of cell motility and invasion by FAK

G. Nemerow, Shuang Huang, D. Schlaepfer, 2003, The Journal of cell biology.

Expression of annexins as a function of cellular growth state

D. Schlaepfer, H. Haigler, 1990, The Journal of cell biology.

Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling

D. Sheppard, D. Schlaepfer, D. Stupack, 2002, The Journal of cell biology.

FAK nuclear export signal sequences

S. Lim, D. Schlaepfer, D. Ilić, 2008, FEBS letters.

Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases

T. Hunter, D. Schlaepfer, 1996, Molecular and cellular biology.

Integrin and Focal Adhesion Kinase Signaling Pathway 1 β v α Matrix Metalloprotease 2 Expression through the Angiopoietin 2 Induces Glioma Cell Invasion by Stimulating

D. Schlaepfer, M. J. Jarzynka, Shi-Yuan Cheng, 2006 .

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

E. Dejana, Xiao Lei Chen, D. Schlaepfer, 2014, The Journal of cell biology.

Characterization of lipocortin I and an immunologically unrelated 33-kDa protein as epidermal growth factor receptor/kinase substrates and phospholipase A2 inhibitors.

D. Schlaepfer, W. Burgess, H. Haigler, 1987, The Journal of biological chemistry.

Identification of a novel annexin in Hydra vulgaris. Characterization, cDNA cloning, and protein kinase C phosphorylation of annexin XII.

H. Bode, D. Schlaepfer, D. Fisher, 1992, The Journal of biological chemistry.

Specific cross-talk between epidermal growth factor receptor and integrin alphavbeta5 promotes carcinoma cell invasion and metastasis.

S. Hanks, D. Schlaepfer, D. Cheresh, 2009, Cancer research.

Tumor FAK orchestrates immunosuppression in ovarian cancer via the CD155/TIGIT axis

V. Kuchroo, M. Rose, Xiao Lei Chen, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Targeting FAK in anti-cancer combination therapies

John C. Dawson, D. Schlaepfer, D. Stupack, 2021 .

Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization.

S. Fisher, P. Elias, K. Feingold, 2007, The American journal of pathology.

Adaptive Resistance to Chemotherapy, A Multi–FAK-torial Linkage

D. Schlaepfer, K. Taylor, 2018, Molecular Cancer Therapeutics.

Autophagy gene haploinsufficiency drives chromosome instability, increases migration, and promotes early ovarian tumors

Katherine K Ortell, O. Harismendy, D. Schlaepfer, 2020, PLoS genetics.

Cortactin as a Target for FAK in the Regulation of Focal Adhesion Dynamics

D. Schlaepfer, M. Ghassemian, Alok Tomar, 2012, PloS one.

Epidermal growth factor dependent phosphorylation of a 35-kilodalton protein in placental membranes.

D. Schlaepfer, E. Sheets, H. Haigler, 1987, Biochemistry.

Cell Adhesion and Focal Adhesion Kinase Regulate Insulin Receptor Substrate-1 Expression*

E. Van Obberghen, D. Schlaepfer, P. Lebrun, 2000, The Journal of Biological Chemistry.

Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-mediated Cyclin D1 Transcription.

T. Lincoln, J. Guan, S. Lim, 2019, Circulation research.

Integrin (cid:2) 4 (cid:3) 1 Promotes Focal Adhesion Kinase-Independent Cell Motility via (cid:2) 4 Cytoplasmic Domain-Speciﬁc Activation of c-Src‡

S. Lim, D. Schlaepfer, S. Mitra, 2005 .

The Cytoplasmic Tyrosine Kinase Pyk2 as a Novel Effector of Fibroblast Growth Factor Receptor 3 Activation*

A. N. Meyer, D. Donoghue, D. Schlaepfer, 2004, Journal of Biological Chemistry.

Human Cytomegalovirus Chemokine Receptor US28 Induced SMC Migration is Mediated by Focal Adhesion Kinase and Src

P. Casarosa, D. Schlaepfer, M. Smit, 2003 .

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK

J. Guan, S. Lim, Xiao Lei Chen, 2008, The Journal of cell biology.

The v-Src SH3 Domain Facilitates a Cell Adhesion-independent Association with Focal Adhesion Kinase*

T. Hunter, D. Schlaepfer, C. Hauck, 2001, The Journal of Biological Chemistry.

v-Src SH3-enhanced Interaction with Focal Adhesion Kinase at β1 Integrin-containing Invadopodia Promotes Cell Invasion*

D. Schlaepfer, C. Hauck, D. Hsia, 2002, The Journal of Biological Chemistry.

Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression

S. Lim, Xiao Lei Chen, D. Schlaepfer, 2012, The Journal of cell biology.

Structural and functional characterization of endonexin II, a calcium- and phospholipid-binding protein.

D. Schlaepfer, T. Mehlman, W. Burgess, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Title Compensatory role for Pyk 2 during angiogenesis in adult mice lacking endothelial cell

J. Guan, S. Lim, Xiao Lei Chen, 2008 .

Analyzing FAK and Pyk2 in Early Integrin Signaling Events

S. Lim, D. Schlaepfer, S. Hou, 2006, Current protocols in cell biology.

A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells

S. Lim, Y. Lim, D. Schlaepfer, 2009, Journal of Cell Science.

The Focal Adhesion Kinase‐‐A Regulator of Cell Migration and Invasion

D. Schlaepfer, C. Hauck, D. Hsia, 2002, IUBMB life.

Targeting Pyk2 to β1-Integrin–Containing Focal Contacts Rescues Fibronectin-Stimulated Signaling and Haptotactic Motility Defects of Focal Adhesion Kinase–Null Cells

D. Schlaepfer, C. Hauck, D. Hsia, 2001, The Journal of cell biology.

Integrin α4 Enhances Metastasis and May Be Associated with Poor Prognosis in MYCNlow Neuroblastoma

D. Pizzo, D. Schlaepfer, D. Stupack, 2015, PloS one.

Title Integrin α 4 enhances metastasis and may be associated with poor prognosis in MYCN low neuroblastoma

Dwayne, D. Schlaepfer, J. Delaney, 2015 .

Grb2 Promotes Integrin-Induced Focal Adhesion Kinase (FAK) Autophosphorylation and Directs the Phosphorylation of Protein Tyrosine Phosphatase α by the Src-FAK Kinase Complex

D. Schlaepfer, C. Pallen, Suzanne Y. S. Cheng, 2013, Molecular and Cellular Biology.

The Cytoskeletal/Non-muscle Isoform of α-Actinin Is Phosphorylated on Its Actin-binding Domain by the Focal Adhesion Kinase*

D. Schlaepfer, B. Haimovich, Yafang Hu, 2001, The Journal of Biological Chemistry.

FAK promotes recruitment of talin to nascent adhesions to control cell motility

S. Lim, Xiao Lei Chen, D. Schlaepfer, 2012, The Journal of Cell Biology.

FAK promotes recruitment of talin to nascent adhesions to control cell motility

S. Lim, Xiao Lei Chen, D. Schlaepfer, 2012, The Journal of cell biology.

Focal adhesion kinase signaling in unexpected places.

D. Schlaepfer, E. Kleinschmidt, Elizabeth G. Kleinschmidt, 2017, Current opinion in cell biology.

Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer.

S. Chien, J. Guan, D. Schlaepfer, 2011, Nature communications.

FAK promotes organization of fibronectin matrix and fibrillar adhesions

C. Damsky, K. Howerton, D. Schlaepfer, 2004, Journal of Cell Science.

Characterization of Ca2+-dependent phospholipid binding and phosphorylation of lipocortin I.

D. Schlaepfer, H. Haigler, 1987, The Journal of biological chemistry.

Involvement of Focal Adhesion Kinase inEscherichia coli Invasion of Human Brain Microvascular Endothelial Cells

N. Prasadarao, D. Schlaepfer, K. Kim, 2000, Infection and Immunity.

Phosphorylation of the Integrin α4 Cytoplasmic Domain Regulates Paxillin Binding*

D. Schlaepfer, M. Ginsberg, Jaewon Han, 2001, The Journal of Biological Chemistry.

Integrin alpha4beta1 promotes focal adhesion kinase-independent cell motility via alpha4 cytoplasmic domain-specific activation of c-Src.

Sakae Tanaka, S. Lim, D. Schlaepfer, 2005, Molecular and cellular biology.

Two lipocortin-like proteins, endonexin II and anchorin CII, may be alternate splices of the same gene.

J. M. Fitch, D. Schlaepfer, H. Haigler, 1989, Trends in biochemical sciences.

Paxillin binding to the alpha 4 integrin subunit stimulates LFA-1 (integrin alpha L beta 2)-dependent T cell migration by augmenting the activation of focal adhesion kinase/proline-rich tyrosine kinase-2.

D. Schlaepfer, M. Ginsberg, Jaewon Han, 2003, Journal of immunology.

Establishment of Cell Lines from Mouse Embryos with Early Embryonic Lethality

K. Howerton, D. Schlaepfer, D. Ilić, 2008, Cell communication & adhesion.

Integrin Subunit Stimulates LFA-1 (Integrin L 2)-Dependent T Cell Migration by Augmenting the Activation of Focal Adhesion Kinase/Proline-Rich Tyrosine Kinase-2

D. Schlaepfer, M. Ginsberg, Jaewon Han, 2003 .

Calcium-dependent Binding of S100C to the N-terminal Domain of Annexin I (*)

D. Schlaepfer, W. Mailliard, H. Haigler, 1996, The Journal of Biological Chemistry.

Purification and biochemical assay of synexin and of the homologous calcium-dependent membrane-binding proteins, endonexin II and lipocortin I.

E. Rojas, H. Pollard, D. Schlaepfer, 1989, Methods in cell biology.

Oxidized LDL induces FAK-dependent RSK signaling to drive NF-κB activation and VCAM-1 expression

D. Schlaepfer, Florian J. Sulzmaier, Arif Yurdagul, 2016, Journal of Cell Science.

Src-inducible association of CrkL with procaspase-8 promotes cell migration

D. Schlaepfer, D. Stupack, R. Graf, 2013, Cell adhesion & migration.

In vitro protein kinase C phosphorylation sites of placental lipocortin.

D. Schlaepfer, H. Haigler, 1988, Biochemistry.

Association of p130CAS with Phosphatidylinositol-3-OH Kinase Mediates Adenovirus Cell Entry*

G. Nemerow, R. Klemke, D. Schlaepfer, 2000, The Journal of Biological Chemistry.

Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein.

M. Jaye, D. Schlaepfer, W. Burgess, 1988, The Journal of biological chemistry.

Inhibition of protein kinase C by annexin V.

D. Schlaepfer, H. Haigler, J. Jones, 1992, Biochemistry.

Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins

T. Hunter, D. Schlaepfer, M. Broome, 1997, Molecular and cellular biology.

Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase

T. Hunter, S. Hanks, D. Schlaepfer, 1994, Nature.

FAK Activation Promotes SMC Dedifferentiation via Increased DNA Methylation in Contractile Genes

Hyun Joon Kim, S. Lim, D. Schlaepfer, 2021, Circulation research.

Human Cytomegalovirus Chemokine Receptor US28-induced Smooth Muscle Cell Migration Is Mediated by Focal Adhesion Kinase and Src*

P. Casarosa, D. Schlaepfer, M. Smit, 2003, Journal of Biological Chemistry.

Signal transduction from the extracellular matrix--a role for the focal adhesion protein-tyrosine kinase FAK.

T. Hunter, D. Schlaepfer, D D Schlaepfer, 1996, Cell structure and function.

Signaling through focal adhesion kinase.

D. Schlaepfer, C. Hauck, D D Schlaepfer, 1999, Progress in biophysics and molecular biology.

Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

G. Mcmahon, D. Schlaepfer, D. Stupack, 2010, Cancer biology & therapy.

Endothelial angiogenic activity and adipose angiogenesis is controlled by extracellular matrix protein TGFBI

In‐San Kim, D. Schlaepfer, S. Lee, 2021, Scientific Reports.

Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells.

D. Schlaepfer, B. Monia, C. Hauck, 2001, Cancer research.

Integrin-regulated FAK-Src signaling in normal and cancer cells.

D. Schlaepfer, S. Mitra, David D Schlaepfer, 2006, Current opinion in cell biology.

Targeting FAK in anticancer combination therapies

John C. Dawson, D. Schlaepfer, M. Frame, 2021, Nature Reviews Cancer.

Multiple connections link FAK to cell motility and invasion.

D. Schlaepfer, S. Mitra, 2004, Current opinion in genetics & development.

EGFR-dependent pancreatic carcinoma cell metastasis via Rap1 activation

David A. Cheresh, S. Anand, D. Schlaepfer, 2011, Oncogene.

Rgnef (p190RhoGEF) Knockout Inhibits RhoA Activity, Focal Adhesion Establishment, and Cell Motility Downstream of Integrins

S. Lim, D. Schlaepfer, N. Miller, 2012, PloS one.

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility

M. Gardel, G. Bokoch, C. Waterman-Storer, 2008, The Journal of cell biology.

PyK 2 and FAK connections to p 190 Rho guanine nucleotide exchange factor regulate RhoA activity , focal adhesion formation , and cell motility

M. Gardel, G. Bokoch, C. Waterman-Storer, 2008 .

Direct Interaction of Focal Adhesion Kinase with p190RhoGEF*

D. Schlaepfer, R. Cañete-Soler, W. Schlaepfer, 2003, Journal of Biological Chemistry.

Haploinsufficiency networks identify targetable patterns of allelic deficiency in low mutation ovarian cancer

O. Harismendy, D. Schlaepfer, D. Stupack, 2017, Nature Communications.

EGFR-Mediated Carcinoma Cell Metastasis Mediated by Integrin αvβ5 Depends on Activation of c-Src and Cleavage of MUC1

S. Anand, S. Lim, D. Schlaepfer, 2012, PloS one.

FERM control of FAK function: Implications for cancer therapy

S. Lim, D. Schlaepfer, D. Mikolon, 2008, Cell cycle.

FAK/PYK2 promotes the Wnt/β-catenin pathway and intestinal tumorigenesis by phosphorylating GSK3β

D. Schlaepfer, Jing Hu, Chenxi Gao, 2015, eLife.

Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover.

M. Schwartz, D. Schlaepfer, W. Kiosses, 2000, Journal of cell science.

A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells

S. Lim, Y. Lim, D. Schlaepfer, 2009, Journal of Cell Science.

Genotype tunes PDAC tension to drive matricellular-enriched fibrosis and tumor aggression

E. Collisson, J. Lakins, V. Weaver, 2016 .

Fluid Shear Stress Activation of Focal Adhesion Kinase

T. Hunter, S. Chien, D. Schlaepfer, 1997, The Journal of Biological Chemistry.

FRNK blocks v‐Src‐stimulated invasion and experimental metastases without effects on cell motility or growth

D. Schlaepfer, D. Cheresh, C. Hauck, 2002, The EMBO journal.

Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model

D. Schlaepfer, S. Mitra, Stephen Lim, 2006, Oncogene.

FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth

D. Schlaepfer, C. Jean, N. Miller, 2015, Breast Cancer Research.

Localized Stabilization of Microtubules by Integrin- and FAK-Facilitated Rho Signaling

D. Schlaepfer, G. Gundersen, Alexander F. Palazzo, 2004, Science.

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments

G. Mcmahon, S. Lim, D. Schlaepfer, 2010, Cancer biology & therapy.

p190RhoGEF (Rgnef) promotes colon carcinoma tumor progression via interaction with focal adhesion kinase.

S. Lim, D. Schlaepfer, Hong-gang Yu, 2011, Cancer research.

RhoGEF ( Rgnef ) Promotes Colon Carcinoma Tumor Progression via Interaction with Focal Adhesion Kinase

S. Lim, D. Schlaepfer, Hong-gang Yu, 2011 .

Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors

D. A. Hanson, D. Schlaepfer, D. Mikolon, 2006, Oncogene.

Extracellular Matrix Survival Signals Transduced by Focal Adhesion Kinase Suppress p53-mediated Apoptosis

C. Damsky, S. Aizawa, D. Schlaepfer, 1998, The Journal of cell biology.

A non-canonical role for Rgnef in promoting integrin-stimulated focal adhesion kinase activation

D. Schlaepfer, N. Miller, S. Uryu, 2013, Journal of Cell Science.

Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair

Andrés J. García, Jianping Fu, D. Schlaepfer, 2020, Nature Communications.

FAK Inhibition Disrupts a β5 Integrin Signaling Axis Controlling Anchorage-Independent Ovarian Carcinoma Growth

D. Schlaepfer, C. Jean, N. Miller, 2014, Molecular Cancer Therapeutics.

Cancer Biology and Signal Transduction FAK Inhibition Disrupts a b 5 Integrin Signaling Axis Controlling Anchorage-Independent Ovarian Carcinoma Growth

D. Schlaepfer, C. Jean, N. Miller, 2014 .

FAK integrates growth-factor and integrin signals to promote cell migration

C. Damsky, D. Schlaepfer, E. Schaefer, 2000, Nature Cell Biology.

Pyk2 and Src‐family protein‐tyrosine kinases compensate for the loss of FAK in fibronectin‐stimulated signaling events but Pyk2 does not fully function to enhance FAK− cell migration

T. Hunter, C. Damsky, D. Schlaepfer, 1998, The EMBO journal.

VEGF-induced vascular permeability is mediated by FAK.

J. Guan, S. Lim, D. Schlaepfer, 2012, Developmental cell.

Focal Adhesion Kinase Facilitates Platelet-derived Growth Factor-BB-stimulated ERK2 Activation Required for Chemotaxis Migration of Vascular Smooth Muscle Cells*

D. Schlaepfer, C. Hauck, D. Hsia, 2000, The Journal of Biological Chemistry.

Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase.

C. Damsky, D. Schlaepfer, Q. Han, 2000 .

Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer.

D. Schlaepfer, C. Jean, N. Miller, 2014, Gynecologic oncology.

Title Analyses of merlin / NF 2 connection to FAK inhibitor responsiveness in serous ovarian cancer

D. Schlaepfer, C. Jean, N. Miller, 2014 .

Snail1 controls epithelial–mesenchymal lineage commitment in focal adhesion kinase–null embryonic cells

S. Weiss, Ann Y Park, J. Guan, 2011, The Journal of cell biology.

A PAK-activated linker for EGFR and FAK.

D. Schlaepfer, Alok Tomar, 2010, Developmental cell.

Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis.

M. Bogyo, D. Schlaepfer, D. Mikolon, 2009, Cancer research.

Tumor Necrosis Factor-α Stimulates Focal Adhesion Kinase Activity Required for Mitogen-activated Kinase-associated Interleukin 6 Expression*

S. Lim, Y. Lim, D. A. Hanson, 2007, Journal of Biological Chemistry.

Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway.

D. Schlaepfer, M. J. Jarzynka, Bo Hu, 2006, Cancer research.

FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion

Su Jie, D. Schlaepfer, Dingzhang Xiao, 2005, The Journal of cell biology.

RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase.

D. Schlaepfer, N. Miller, E. Kleinschmidt, 2014, Current molecular medicine.

Gastrin-stimulated Gα13 Activation of Rgnef Protein (ArhGEF28) in DLD-1 Colon Carcinoma Cells*

D. Schlaepfer, N. Miller, L. Pérez-Benito, 2015, The Journal of Biological Chemistry.

Matrix Survival Signaling

C. Damsky, D. Schlaepfer, Q. Han, 2000, The Journal of cell biology.

kinase regulates expression.

S. Lim, D. Schlaepfer, D. Cheresh, 2012 .

Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells

Hye‐Jin Kim, Jung Weon Lee, Suyong Choi, 2012, Journal of Cell Science.

Pyk2 Inhibition of p53 as an Adaptive and Intrinsic Mechanism Facilitating Cell Proliferation and Survival*

S. Lim, Y. Lim, D. Schlaepfer, 2009, The Journal of Biological Chemistry.

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK.

P. Tamayo, E. Ruppin, J. Lee, 2019, Cancer cell.

A strategy to combine pathway-targeted low toxicity drugs in ovarian cancer

D. Schlaepfer, D. Stupack, J. Delaney, 2015, Oncotarget.

Integrin signalling and tyrosine phosphorylation: just the FAKs?

T. Hunter, D. Schlaepfer, 1998, Trends in cell biology.

αvβ3-integrin-dependent activation of focal adhesion kinase mediates NF-κB activation and motogenic activity by HIV-1 Tat in endothelial cells

Marco Presta, Marco Rusnati, Mauro Giacca, 2005, Journal of Cell Science.

alpha(v)beta3-integrin-dependent activation of focal adhesion kinase mediates NF-kappaB activation and motogenic activity by HIV-1 Tat in endothelial cells.

Marco Presta, Marco Rusnati, Mauro Giacca, 2005, Journal of cell science.

Paxillin Binding to the α4 Integrin Subunit Stimulates LFA-1 (Integrin αLβ2)-Dependent T Cell Migration by Augmenting the Activation of Focal Adhesion Kinase/Proline-Rich Tyrosine Kinase-21

D. Schlaepfer, M. Ginsberg, Jaewon Han, 2003, The Journal of Immunology.

Differential Ligand Binding to a Human Cytomegalovirus Chemokine Receptor Determines Cell Type–Specific Motility

K. Früh, D. Schlaepfer, M. Smit, 2009, PLoS pathogens.

Rgnef promotes ovarian tumor progression and confers protection from oxidative stress

D. Schlaepfer, D. Stupack, N. Miller, 2019, Oncogene.

FAK activity in cancer‐associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer

D. Schlaepfer, R. Tomasini, C. Jean, 2020, EMBO molecular medicine.

Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression

D. Tarin, D. Schlaepfer, C. Jean, 2013, Clinical & Experimental Metastasis.

FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy

B. Győrffy, J. Heino, D. Schlaepfer, 2019, bioRxiv.

pHocal adhesion kinase regulation is on a FERM foundation

D. Schlaepfer, C. Lawson, 2013, The Journal of cell biology.

Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility.

D. Schlaepfer, D. Mikolon, D. Stupack, 2008, Oncogene.

Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration

D. Schlaepfer, C. Hauck, D D Schlaepfer, 2000, Immunologic research.

Crystal structure of the annexin XII hexamer and implications for bilayer insertion

H. Luecke, D. Schlaepfer, David D. Schlaepfer, 1995, Nature.

Grb2 regulates FAK activation and PTPα-FAK association Grb2 Promotes Integrin-induced Focal Adhesion Kinase (FAK) Autophosphorylation and Directs the Phosphorylation of PTPα by the Src-FAK Kinase Complex

D. Schlaepfer, C. Pallen, Suzanne Y. S. Cheng, 2013 .

Integrin adhesions

D. Schlaepfer, C. Lawson, 2012, Cell adhesion & migration.

FAK signaling is critical for ErbB-2/ErbB-3 receptor cooperation for oncogenic transformation and invasion

D. Schlaepfer, Dingzhang Xiao, Qiang He, 2005, The Journal of cell biology.

Abstract 968: Targeting FAK inhibits YAP-dependent tumor growth in uveal melanoma

P. Tamayo, E. Ruppin, D. Schlaepfer, 2018, Molecular and Cellular Biology / Genetics.

A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells

S. Lim, D. Schlaepfer, Alok Tomar, 2009, Journal of Cell Science.

Targeting Pyk2 to β1-Integrin–Containing Focal Contacts Rescues Fibronectin-Stimulated Signaling and Haptotactic Motility Defects of Focal Adhesion Kinase–Null Cells

D. Schlaepfer, C. Hauck, C. Klingbeil, 2001, The Journal of cell biology.

Rgnef promotes ovarian tumor progression and confers protection from oxidative stress

D. Schlaepfer, D. Stupack, D. Connolly, 2019, Oncogene.

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility

M. Gardel, G. Bokoch, C. Waterman-Storer, 2008, The Journal of cell biology.

v-Src SH3-enhanced Interaction with Focal Adhesion Kinase at β1 Integrin-containing Invadopodia Promotes Cell Invasion*

D. Schlaepfer, C. Hauck, D. Ilić, 2002, The Journal of Biological Chemistry.

Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

C. Iacobuzio-Donahue, E. Collisson, J. Lakins, 2023, Nature medicine.

TGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway

D. Schlaepfer, S. Woo, T. Kwon, 2023, Experimental & Molecular Medicine.

Caspase-8 association with the focal adhesion complex promotes tumor cell migration and metastasis.

M. Bogyo, D. Schlaepfer, D. Mikolon, 2009, Cancer research.

Grb2 Promotes Integrin-Induced Focal Adhesion Kinase (FAK) Autophosphorylation and Directs the Phosphorylation of Protein Tyrosine Phosphatase α by the Src-FAK Kinase Complex

D. Schlaepfer, C. Pallen, Suzanne Y. S. Cheng, 2013, Molecular and Cellular Biology.