T. Tumpey

T. Tumpey, S. H. Chen, J. Oakes, 1996, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

A Novel A(H7N2) Influenza Virus Isolated from a Veterinarian Caring for Cats in a New York City Animal Shelter Causes Mild Disease and Transmits Poorly in the Ferret Model

T. Tumpey, T. Maines, J. Belser, 2017, Journal of Virology.

Prophylactic and Therapeutic Efficacy of Avian Antibodies Against Influenza Virus H5N1 and H1N1 in Mice

T. Tumpey, C. Czerkinsky, P. Kilgore, 2010, PloS one.

Human HA and polymerase subunit PB2 proteins confer transmission of an avian influenza virus through the air

A. García-Sastre, T. Tumpey, R. Sasisekharan, 2009, Proceedings of the National Academy of Sciences.

Comparative Efficacy of Hemagglutinin, Nucleoprotein, and Matrix 2 Protein Gene-Based Vaccination against H5N1 Influenza in Mouse and Ferret

G. Nabel, W. Kong, T. Tumpey, 2010, PloS one.

Protective immunity to lethal challenge of the 1918 pandemic influenza virus by vaccination

G. Nabel, A. García-Sastre, W. Kong, 2006, Proceedings of the National Academy of Sciences.

DNA priming and influenza vaccine immunogenicity: two phase 1 open label randomised clinical trials

J. Mascola, R. Koup, G. Nabel, 2011, The Lancet Infectious Diseases.

Domestic Poultry and SARS Coronavirus, Southern China

T. Tumpey, T. Ksiazek, P. Rollin, 2004, Emerging infectious diseases.

Kinetics of viral replication and induction of host responses in ferrets differs between ocular and intranasal routes of inoculation.

T. Tumpey, J. Katz, T. Maines, 2013, Virology.

Bifunctional Polymeric Inhibitors of Human Influenza A Viruses

Jianzhu Chen, L. Gubareva, A. Klibanov, 2010, Pharmaceutical Research.

Zanamivir Conjugated to Poly-L-Glutamine is Much More Active Against Influenza Viruses in Mice and Ferrets Than the Drug Itself

Jianzhu Chen, A. Klibanov, T. Tumpey, 2013, Pharmaceutical Research.

Vaccines against avian influenza A H9N2 viruses

N. Cox, T. Tumpey, J. Katz, 2001 .

A guide for the use of the ferret model for influenza virus infection.

T. Tumpey, T. Maines, J. Belser, 2020, The American journal of pathology.

In vitro exposure system for study of aerosolized influenza virus

T. Tumpey, T. Maines, J. Belser, 2016, Virology.

Mammalian Pathogenesis and Transmission of H7N9 Influenza Viruses from Three Waves, 2013-2015

T. Tumpey, W. Shieh, T. Maines, 2016, Journal of Virology.

H7N9 and Other Pathogenic Avian Influenza Viruses Elicit a Three-Pronged Transcriptomic Signature That Is Reminiscent of 1918 Influenza Virus and Is Associated with Lethal Outcome in Mice

M. Katze, N. Tchitchek, T. Tumpey, 2014, Journal of Virology.

Tropism of H7N9 influenza viruses in the human respiratory tract.

T. Tumpey, J. Belser, 2013, The Lancet. Respiratory medicine.

Pathogenicity testing of influenza candidate vaccine viruses in the ferret model.

T. Tumpey, J. Katz, Li-mei Chen, 2017, Virology.

A novel eight amino acid insertion contributes to the hemagglutinin cleavability and the virulence of a highly pathogenic avian influenza A (H7N3) virus in mice.

T. Tumpey, J. Belser, Xiangjie Sun, 2016, Virology.

Hydrophobic polycationic coatings inactivate wild-type and zanamivir- and/or oseltamivir-resistant human and avian influenza viruses

Jianzhu Chen, L. Gubareva, A. Klibanov, 2008, Biotechnology Letters.

Transmission Studies Resume for Avian Flu

Y. Guan, R. Webster, R. Webby, 2013, Science.

Pause on avian flu transmission research.

Y. Guan, R. Webster, R. Webby, 2012, Science.

Recombinant virus-like particles elicit protective immunity against avian influenza A(H7N9) virus infection in ferrets.

T. Tumpey, G. Glenn, T. Maines, 2015, Vaccine.

Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus

Carole R. Baskin, Michael G. Katze, Adolfo García-Sastre, 2009, Proceedings of the National Academy of Sciences.

Functional Genomic and Serological Analysis of the Protective Immune Response Resulting from Vaccination of Macaques with an NS1-Truncated Influenza Virus

M. Katze, S. Proll, A. García-Sastre, 2007, Journal of Virology.

Functional Genomic and Serological Analysis of the Protective Immune Response Resulting from Vaccination of Macaques with an NS1-Truncated Influenza Virus

M. Katze, S. Proll, A. García-Sastre, 2007, Journal of Virology.

Influence of Immune Priming and Egg Adaptation in the Vaccine on Antibody Responses to Circulating A(H1N1)pdm09 Viruses After Influenza Vaccination in Adults

Xiyan Xu, F. Liu, T. Tumpey, 2018, The Journal of infectious diseases.

Role for macrophage inflammatory protein 2 (MIP-2), MIP-1alpha, and interleukin-1alpha in the delayed-type hypersensitivity response to viral antigen.

T. Tumpey, J. Oakes, R. Lausch, 2002, Journal of virology.

Role for Macrophage Inflammatory Protein 2 (MIP-2), MIP-1α, and Interleukin-1α in the Delayed-Type Hypersensitivity Response to Viral Antigen

T. Tumpey, J. Oakes, R. Lausch, 2002, Journal of Virology.

Genomic Analysis Reveals Age-Dependent Innate Immune Responses to Severe Acute Respiratory Syndrome Coronavirus (cid:1) †

M. Katze, K. Subbarao, A. Roberts, 2008 .

Antibody Landscape Analysis following Influenza Vaccination and Natural Infection in Humans with a High-Throughput Multiplex Influenza Antibody Detection Assay

T. Tumpey, Jessie C. Chang, P. Carney, 2021, mBio.

Mono- and quadri-subtype virus-like particles (VLPs) containing H10 subtype elicit protective immunity to H10 influenza in a ferret challenge model.

T. Tumpey, T. Maines, J. Belser, 2016, Vaccine.

Pathogenesis of Avian Inﬂuenza (H7) Virus Infection in Mice and Ferrets: Enhanced Virulence of Eurasian H7N7 Viruses Isolated from Humans (cid:1)

T. Tumpey, R. Donis, J. Katz, 2007 .

Stockpiled pre-pandemic H5N1 influenza virus vaccines with AS03 adjuvant provide cross-protection from H5N2 clade 2.3.4.4 virus challenge in ferrets.

F. Liu, T. Tumpey, Zhu Guo, 2017, Virology.

Genomic Proﬁling of Tumor Necrosis Factor Alpha (TNF- (cid:1) ) Receptor and Interleukin-1 Receptor Knockout Mice Reveals a Link between TNF- (cid:1) Signaling and Increased Severity of 1918 Pandemic Inﬂuenza Virus Infection (cid:1) †

M. Katze, S. Proll, M. J. Korth, 2010 .

H5N1 VLP vaccine induced protection in ferrets against lethal challenge with highly pathogenic H5N1 influenza viruses.

T. Tumpey, T. Ross, R. Bright, 2008, Vaccine.

Pathogenesis and Transmission of Genetically Diverse Swine-Origin H3N2 Variant Influenza A Viruses from Multiple Lineages Isolated in the United States, 2011–2016

C. Davis, T. Tumpey, T. Maines, 2018, Journal of Virology.

Intranasal vaccination with H5, H7 and H9 hemagglutinins co-localized in a virus-like particle protects ferrets from multiple avian influenza viruses.

T. Tumpey, M. Pearce, Melissa B. Pearce, 2013, Virology.

Airborne Transmission of Highly Pathogenic Influenza Virus during Processing of Infected Poultry

T. Tumpey, D. Swayne, K. Bertran, 2017, Emerging infectious diseases.

Inherent Heterogeneity of Influenza A Virus Stability following Aerosolization

T. Tumpey, T. Maines, J. Belser, 2022, Applied and environmental microbiology.

Mammalian pathogenicity and transmissibility of low pathogenic avian influenza H7N1 and H7N3 viruses isolated from North America in 2018

C. Davis, T. Tumpey, T. Maines, 2020, Emerging microbes & infections.

Comparison of traditional intranasal and aerosol inhalation inoculation of mice with influenza A viruses.

T. Tumpey, J. Katz, T. Maines, 2015, Virology.

Absence of Macrophage Inflammatory Protein-1α Prevents the Development of Blinding Herpes Stromal Keratitis

T. Tumpey, O. Smithies, D. Cook, 1998, Journal of Virology.

Heterosubtypic immunity against human influenza A viruses, including recently emerged avian H5 and H9 viruses, induced by FLU-ISCOM vaccine in mice requires both cytotoxic T-lymphocyte and macrophage function.

T. Tumpey, J. Katz, S. Sambhara, 2001, Cellular immunology.

Role of macrophages in restricting herpes simplex virus type 1 growth after ocular infection.

T. Tumpey, H. Cheng, H. Staats, 2000, Investigative ophthalmology & visual science.

Chemokine synthesis in the HSV‐1‐infected cornea and its suppression by interleukin‐10

T. Tumpey, J. Oakes, R. Lausch, 1998, Journal of leukocyte biology.

Human Monoclonal Antibodies to Pandemic 1957 H2N2 and Pandemic 1968 H3N2 Inﬂuenza Viruses

J. Crowe, K. Edwards, Jens C. Krause, 2012 .

Antibodies by Vaccination Induction of Broadly Neutralizing H 1 N 1 Influenza

G. Nabel, P. McTamney, W. Kong, 2010 .

Effect of D222G Mutation in the Hemagglutinin Protein on Receptor Binding, Pathogenesis and Transmissibility of the 2009 Pandemic H1N1 Influenza Virus

Rahul Raman, Hui Zeng, Ram Sasisekharan, 2011, PloS one.

Impact of Prior Seasonal H3N2 Influenza Vaccination or Infection on Protection and Transmission of Emerging Variants of Influenza A(H3N2)v Virus in Ferrets

T. Tumpey, J. Katz, M. Pearce, 2013, Journal of Virology.

Seasonal Trivalent Inactivated Influenza Vaccine Does Not Protect against Newly Emerging Variants of Influenza A (H3N2v) Virus in Ferrets

T. Tumpey, J. Katz, Katherine V. Houser, 2012, Journal of Virology.

Oseltamivir Inhibits H7 Influenza Virus Replication in Mice Inoculated by the Ocular Route

L. Gubareva, T. Tumpey, J. Katz, 2011, Antimicrobial Agents and Chemotherapy.

Swine-Origin H1 Influenza Viruses Isolated from Humans Exhibit Sustained Infectivity in an Aerosol State

T. Tumpey, T. Maines, J. Belser, 2019, Applied and Environmental Microbiology.

Pathogenesis and Transmission of Triple-Reassortant Swine H1N1 Inﬂuenza Viruses Isolated before the 2009 H1N1 Pandemic (cid:1)

T. Tumpey, S. Zaki, J. Katz, 2011 .

Ocular Infection of Mice with Inﬂuenza A (H7) Viruses: a Site of Primary Replication and Spread to the Respiratory Tract (cid:1)

T. Tumpey, J. Katz, J. Belser, 2009 .

Comparison of vaccines for induction of heterosubtypic immunity to influenza A virus: cold-adapted vaccine versus DNA prime-adenovirus boost strategies.

W. Kong, T. Tumpey, C. Pappas, 2008, Vaccine.

Comparative Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Variants in the Ferret Model

Troy J. Kieran, T. Tumpey, T. Maines, 2022, mBio.

Early Control of H5N1 Inﬂuenza Virus Replication by the Type I Interferon Response in Mice (cid:1)

Y. Matsuoka, Hualan Chen, T. Tumpey, 2009 .

DNA vaccine expressing conserved influenza virus proteins protective against H5N1 challenge infection in mice.

K. Subbarao, T. Tumpey, J. Katz, 2002, Emerging infectious diseases.

Experimental Infection of Pigs with the Human 1918 Pandemic Inﬂuenza Virus (cid:1)

R. Albrecht, A. García-Sastre, T. Tumpey, 2009 .

Heterologous prime-boost with A(H5N1) pandemic influenza vaccines induces broader cross-clade antibody responses than homologous prime-boost

T. Tumpey, J. Stevens, J. Katz, 2019, npj Vaccines.

Mammalian pathogenicity and transmissibility of a reassortant Eurasian avian-like A(H1N1v) influenza virus associated with human infection in China (2015).

T. Tumpey, T. Maines, J. Belser, 2019, Virology.

Neuraminidase-based recombinant virus-like particles protect against lethal avian influenza A(H5N1) virus infection in ferrets.

T. Tumpey, G. Glenn, T. Maines, 2017, Virology.

Preparation of quadri-subtype influenza virus-like particles using bovine immunodeficiency virus gag protein.

T. Tumpey, P. Pushko, I. Tretyakova, 2016, Virology.

Oseltamivir inhibits influenza virus replication and transmission following ocular-only aerosol inoculation of ferrets.

T. Tumpey, J. Katz, T. Maines, 2015, Virology.

Recombinant H7 hemagglutinin forms subviral particles that protect mice and ferrets from challenge with H7N9 influenza virus.

J. Taubenberger, T. Tumpey, Xiangjie Sun, 2015, Vaccine.

Influenza Virus Infectivity and Virulence following Ocular-Only Aerosol Inoculation of Ferrets

T. Tumpey, J. Katz, T. Maines, 2014, Journal of Virology.

Mammalian Pathogenesis and Transmission of Avian Influenza A(H7N9) Viruses, Tennessee, USA, 2017

T. Tumpey, T. Maines, J. Belser, 2018, Emerging infectious diseases.

An influenza A virus (H7N9) anti-neuraminidase monoclonal antibody protects mice from morbidity without interfering with the development of protective immunity to subsequent homologous challenge.

T. Tumpey, Jessie C. Chang, Zhu Guo, 2017, Virology.

The development of vaccine viruses against pandemic A(H1N1) influenza.

C. Davis, N. Cox, Xiyan Xu, 2011, Vaccine.

Characterization of the murine Th2 response to immunization with liposomal M2e influenza vaccine.

T. Tumpey, H. Zeng, J. Adler-Moore, 2011, Vaccine.

2009 H1N1 swine flu: the 2010 perspective

P. Dormitzer, T. Tumpey, Anice C. Lowen, 2010, Annals of the New York Academy of Sciences.

Identification of novel influenza A virus exposures by an improved high‐throughput multiplex MAGPIX platform and serum adsorption

F. Liu, T. Tumpey, Jessie C. Chang, 2019, Influenza and other respiratory viruses.

Recombinant Paramyxovirus Type 1-Avian Influenza-H7 Virus as a Vaccine for Protection of Chickens Against Influenza and Newcastle Disease

A. García-Sastre, T. Tumpey, S. Schultz-Cherry, 2003, Avian diseases.

A Single Amino Acid Substitution in 1918 Inﬂuenza Virus Hemagglutinin Changes Receptor Binding Speciﬁcity

J. Taubenberger, A. García-Sastre, T. Tumpey, 2005 .

Development of a Virosome Vaccine for Newcastle Disease Virus

T. Tumpey, D. Kapczynski, 2003, Avian diseases.

Vaccination with virus-like particles containing H5 antigens from three H5N1 clades protects chickens from H5N1 and H5N8 influenza viruses.

T. Tumpey, D. Kapczynski, K. Chrzastek, 2016, Vaccine.

Evolution of H5N1 Avian Influenza Viruses in Asia

Keiji Fukuda, David E. Swayne, Nguyen Tien Dung, 2005, Emerging infectious diseases.

Low quality antibody responses in critically ill patients hospitalized with pandemic influenza A(H1N1)pdm09 virus infection

T. Uyeki, T. Tumpey, Zhu Guo, 2022, Scientific reports.

Influenza A(H7N9) Pandemic Preparedness: Assessment of the Breadth of Heterologous Antibody Responses to Emerging Viruses from Multiple Pre-Pandemic Vaccines and Population Immunity

C. Davis, T. Tumpey, J. Stevens, 2022, Vaccines.

Neutrophil-mediated suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea

T. Tumpey, S. H. Chen, J. Oakes, 1996, Journal of virology.

Utility of Human In Vitro Data in Risk Assessments of Influenza A Virus Using the Ferret Model

Troy J. Kieran, C. Beauchemin, T. Tumpey, 2023, Journal of Virology.

Human Pulmonary Microvascular Endothelial Cells Support Productive Replication of Highly Pathogenic Avian Influenza Viruses: Possible Involvement in the Pathogenesis of Human H5N1 Virus Infection

T. Tumpey, J. Katz, J. Belser, 2011, Journal of Virology.

The guinea pig as a transmission model for human influenza viruses.

Adolfo García-Sastre, Samira Mubareka, A. García-Sastre, 2006, Proceedings of the National Academy of Sciences of the United States of America.

IFN-gamma and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice.

T. Tumpey, A. Finnegan, R. Hendricks, 1992, Journal of immunology.

Critical role of corneal Langerhans cells in the CD4- but not CD8-mediated immunopathology in herpes simplex virus-1-infected mouse corneas.

T. Tumpey, R. Hendricks, M. Janowicz, 1992, Journal of immunology.

Concurrent regeneration of T lymphocytes and susceptibility to HSV-1 corneal stromal disease.

T. Tumpey, R. Hendricks, 1991, Current eye research.

Contribution of virus and immune factors to herpes simplex virus type I-induced corneal pathology.

T. Tumpey, R. Hendricks, 1990, Investigative ophthalmology & visual science.

Isolation and Characterization of Avian Influenza Viruses, Including Highly Pathogenic H5N1, from Poultry in Live Bird Markets in Hanoi, Vietnam, in 2001

David E. Swayne, Amanda Balish, Timothy M. Uyeki, 2005, Journal of Virology.

Characterization of Highly Pathogenic H5N1 Avian Influenza A Viruses Isolated from South Korea

T. Tumpey, D. Suarez, Jae-Hong Kim, 2005, Journal of Virology.

A Mouse Model for the Evaluation of Pathogenesis and Immunity to Influenza A (H5N1) Viruses Isolated from Humans

N. Cox, T. Tumpey, S. Zaki, 1999, Journal of Virology.

Influenza A virus transmission: contributing factors and clinical implications

T. Tumpey, J. Katz, T. Maines, 2010, Expert Reviews in Molecular Medicine.

Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus

David E. Swayne, Hui Zeng, Jeffery K. Taubenberger, 2005, Science.

The effect of cellular immune tolerance to HSV-1 antigens on the immunopathology of HSV-1 keratitis.

T. Tumpey, R. Hendricks, R. Epstein, 1989, Investigative ophthalmology & visual science.

Interleukin-10 treatment can suppress stromal keratitis induced by herpes simplex virus type 1.

T. Tumpey, V. Elner, S. H. Chen, 1994, Journal of immunology.

Protection against lethal influenza virus challenge by RNA interference in vivo.

T. Tumpey, S. Tompkins, C. Lo, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Endogenously produced interferon alpha protects mice from herpes simplex virus type 1 corneal disease.

T. Tumpey, P. C. Weber, J. Glorioso, 1991, The Journal of general virology.

Contribution of Virus ond Immune Factors to Herpes Simplex Virus Type l-lnduced Corneal Pathology

T. Tumpey, R. Hendricks, 2005 .

Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus.

J. Taubenberger, A. García-Sastre, T. Tumpey, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Novel Pandemic Influenza A(H1N1) Viruses Are Potently Inhibited by DAS181, a Sialidase Fusion Protein

Fang Fang, Vasiliy P. Mishin, Larisa V. Gubareva, 2009, PloS one.

Pathogenicity of Influenza Viruses with Genes from the 1918 Pandemic Virus: Functional Roles of Alveolar Macrophages and Neutrophils in Limiting Virus Replication and Mortality in Mice

David E. Swayne, Jeffery K. Taubenberger, J. Taubenberger, 2005, Journal of Virology.

Characterization of highly pathogenic avian influenza H5Nx viruses in the ferret model

T. Tumpey, T. Maines, J. Belser, 2020, Scientific Reports.

Resurrected pandemic influenza viruses.

T. Tumpey, J. Belser, 2009, Annual review of microbiology.

Use of animal models to understand the pandemic potential of highly pathogenic avian influenza viruses.

T. Tumpey, J. Katz, Kristy J. Szretter, 2009, Advances in virus research.

The ferret as a model organism to study influenza A virus infection

T. Tumpey, J. Katz, J. Belser, 2011, Disease Models & Mechanisms.

Differential microRNA expression and virulence of avian, 1918 reassortant, and reconstructed 1918 influenza A viruses.

Yu Li, Carole R Baskin, M. Katze, 2011, Virology.

H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice

Lucy A. Perrone, A. García-Sastre, T. Tumpey, 2008, PLoS pathogens.

Lethal Dissemination of H5N1 Influenza Virus Is Associated with Dysregulation of Inflammation and Lipoxin Signaling in a Mouse Model of Infection

Xinxia Peng, David E. Swayne, Michael G. Katze, 2010, Journal of Virology.

Epitope-Specific Human Influenza Antibody Repertoires Diversify by B Cell Intraclonal Sequence Divergence and Interclonal Convergence

James E Crowe, J. Crowe, B. Briney, 2011, The Journal of Immunology.

ConvergenceSequence Divergence and Interclonal Repertoires Diversify by B Cell Intraclonal Epitope-Specific Human Influenza Antibody

J. Crowe, B. Briney, Jens C. Krause, 2011 .

Assessment of transmission, pathogenesis and adaptation of H2 subtype influenza viruses in ferrets.

T. Tumpey, Hua Yang, P. Carney, 2015, Virology.

Sowing the Seeds of a Pandemic? Mammalian Pathogenicity and Transmissibility of H1 Variant Influenza Viruses from the Swine Reservoir

T. Tumpey, T. Maines, J. Belser, 2019, Tropical medicine and infectious disease.

Importance of 1918 virus reconstruction to current assessments of pandemic risk.

T. Tumpey, T. Maines, J. Belser, 2018, Virology.

An early 'classical' swine H1N1 influenza virus shows similar pathogenicity to the 1918 pandemic virus in ferrets and mice.

J. Taubenberger, T. Tumpey, Z. Sheng, 2009, Virology.

Global Host Immune Response: Pathogenesis and Transcriptional Profiling of Type A Influenza Viruses Expressing the Hemagglutinin and Neuraminidase Genes from the 1918 Pandemic Virus

M. Katze, J. Taubenberger, A. García-Sastre, 2004, Journal of Virology.

Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus

J. Taubenberger, A. García-Sastre, T. Tumpey, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Integrated Molecular Signature of Disease: Analysis of Influenza Virus-Infected Macaques through Functional Genomics and Proteomics

M. Katze, S. Proll, D. L. Diamond, 2006, Journal of Virology.

Historical and clinical aspects of the 1918 H1N1 pandemic in the United States.

T. Uyeki, T. Tumpey, D. Jernigan, 2019, Virology.

The NS1 Protein of the 1918 Pandemic Influenza Virus Blocks Host Interferon and Lipid Metabolism Pathways

Michael G. Katze, Hui Zeng, M. Katze, 2009, Journal of Virology.

A Single Mutation in the PB1-F2 of H5N1 (HK/97) and 1918 Influenza A Viruses Contributes to Increased Virulence

Lucy A. Perrone, T. Tumpey, P. Palese, 2007, PLoS pathogens.

A Single Amino Acid Substitution in 1918 Influenza Virus Hemagglutinin Changes Receptor Binding Specificity

Ian A. Wilson, James Stevens, Jeffery K. Taubenberger, 2005, Journal of Virology.

Highly Pathogenic Avian Influenza H5N1 Viruses Elicit an Attenuated Type I Interferon Response in Polarized Human Bronchial Epithelial Cells

T. Tumpey, C. Goldsmith, S. Zaki, 2007, Journal of Virology.

Title Novel pandemic influenza A ( H 1 N 1 ) viruses are potently inhibitedby DAS 181 , a sialidase fusion protein

R. Moss, L. Gubareva, T. Tumpey, 2009 .

Induction of Broadly Neutralizing H1N1 Influenza Antibodies by Vaccination

G. Nabel, P. McTamney, W. Kong, 2010, Science.

Vaccination focusing immunity on conserved antigens protects mice and ferrets against virulent H1N1 and H5N1 influenza A viruses.

Mark R. Soboleski, T. Tumpey, C. Pappas, 2009, Vaccine.

Single gene reassortants identify a critical role for PB1, HA, and NA in the high virulence of the 1918 pandemic influenza virus

Lucy A. Perrone, A. García-Sastre, T. Tumpey, 2008, Proceedings of the National Academy of Sciences.

Quantitative biochemical rationale for differences in transmissibility of 1918 pandemic influenza A viruses

A. Srinivasan, V. Sasisekharan, T. Tumpey, 2008, Proceedings of the National Academy of Sciences.

Experimental Infection of Pigs with the Human 1918 Pandemic Influenza Virus

R. Albrecht, A. García-Sastre, T. Tumpey, 2009, Journal of Virology.

A Two-Amino Acid Change in the Hemagglutinin of the 1918 Influenza Virus Abolishes Transmission

David E. Swayne, N. Cox, A. García-Sastre, 2007, Science.

A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses

L. Gubareva, T. Tumpey, Xiangjie Sun, 2012, PloS one.

Elicitation of Anti-1918 Influenza Virus Immunity Early in Life Prevents Morbidity and Lower Levels of Lung Infection by 2009 Pandemic H1N1 Influenza Virus in Aged Mice

C. Wiley, T. Tumpey, T. Ross, 2011, Journal of Virology.

Single-Dose Mucosal Immunization with a Candidate Universal Influenza Vaccine Provides Rapid Protection from Virulent H5N1, H3N2 and H1N1 Viruses

Mark R. Soboleski, T. Tumpey, C. Pappas, 2010, PloS one.

Integration of Clinical Data, Pathology, and cDNA Microarrays in Influenza Virus-Infected Pigtailed Macaques (Macaca nemestrina)

Carole R. Baskin, Michael G. Katze, M. Katze, 2004, Journal of Virology.

PB1-F2 Expression by the 2009 Pandemic H1N1 Influenza Virus Has Minimal Impact on Virulence in Animal Models

A. García-Sastre, T. Tumpey, R. Hai, 2010, Journal of Virology.

Molecular Correlates of Influenza A H5N1 Virus Pathogenesis in Mice

Michael W. Shaw, M. Shaw, K. Subbarao, 2000, Journal of Virology.

Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein.

G. Nabel, W. Kong, T. Tumpey, 2005, Vaccine.

Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1

T. Tumpey, S. Tompkins, Z. Ye, 2007, Emerging infectious diseases.

5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication

L. Gubareva, P. Ranjan, A. García-Sastre, 2010, Virology Journal.

Genomic Profiling of Tumor Necrosis Factor Alpha (TNF-α) Receptor and Interleukin-1 Receptor Knockout Mice Reveals a Link between TNF-α Signaling and Increased Severity of 1918 Pandemic Influenza Virus Infection

David E. Swayne, Michael G. Katze, Sarah E. Belisle, 2010, Journal of Virology.

Immunity to influenza

T. Tumpey, J. Katz, S. Sambhara, 2004, Immunologic research.

Heterologous prime-boost with A(H5N1) pandemic influenza vaccines induces broader cross-clade antibody responses than homologous prime-boost

T. Tumpey, J. Stevens, J. Katz, 2019, npj Vaccines.

The Alpha/Beta Interferon Receptor Provides Protection against Influenza Virus Replication but Is Dispensable for Inflammatory Response Signaling

Xinxia Peng, M. Katze, S. Proll, 2009, Journal of Virology.

A live attenuated H1N1 M1 mutant provides broad cross-protection against influenza A viruses, including highly pathogenic A/Vietnam/1203/2004, in mice.

T. Tumpey, Hang Xie, J. Katz, 2009, The Journal of infectious diseases.

Molecular Signatures Associated with Mx1-Mediated Resistance to Highly Pathogenic Influenza Virus Infection: Mechanisms of Survival

M. Katze, Chester Ni, M. J. Korth, 2011, Journal of Virology.

Constitutively Expressed IFITM3 Protein in Human Endothelial Cells Poses an Early Infection Block to Human Influenza Viruses

T. Tumpey, T. Maines, J. Belser, 2016, Journal of Virology.

Pathogenesis and transmission of swine origin A(H3N2)v influenza viruses in ferrets

N. Cox, T. Tumpey, R. Sasisekharan, 2012, Proceedings of the National Academy of Sciences.

Multiple genes contribute to the virulent phenotype observed in ferrets of an H5N1 influenza virus isolated from Thailand in 2004.

T. Tumpey, R. Donis, J. Katz, 2011, Virology.

NS-based live attenuated H1N1 pandemic vaccines protect mice and ferrets.

A. García-Sastre, T. Tumpey, Bin Zhou, 2010, Vaccine.

Detection of Airborne Influenza A and SARS-CoV-2 Virus Shedding following Ocular Inoculation of Ferrets

Troy J. Kieran, T. Tumpey, T. Maines, 2022, Journal of virology.

Mammalian models for the study of H7 virus pathogenesis and transmission.

T. Tumpey, J. Belser, 2014, Current topics in microbiology and immunology.

Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin

A. Srinivasan, V. Sasisekharan, T. Tumpey, 2008, Nature Biotechnology.

Simvastatin and oseltamivir combination therapy does not improve the effectiveness of oseltamivir alone following highly pathogenic avian H5N1 influenza virus infection in mice.

T. Tumpey, J. Katz, Kristy J. Szretter, 2013, Virology.

Genetically and Antigenically Divergent Influenza A(H9N2) Viruses Exhibit Differential Replication and Transmission Phenotypes in Mammalian Models

C. Davis, Dayan Wang, T. Tumpey, 2020, Journal of Virology.

Considerations regarding appropriate sample size for conducting ferret transmission experiments.

T. Tumpey, J. Katz, T. Maines, 2013, Future microbiology.

Glycosylations in the Globular Head of the Hemagglutinin Protein Modulate the Virulence and Antigenic Properties of the H1N1 Influenza Viruses

R. Belshe, R. Albrecht, A. García-Sastre, 2013, Science Translational Medicine.

Efficacy of seasonal live attenuated influenza vaccine against virus replication and transmission of a pandemic 2009 H1N1 virus in ferrets.

T. Tumpey, J. Katz, J. Belser, 2011, Vaccine.

An Insertion Mutation That Distorts Antibody Binding Site Architecture Enhances Function of a Human Antibody

I. Wilson, J. Crowe, D. Ekiert, 2011, mBio.

Effect of D 222 G Mutation in the Hemagglutinin Protein on Receptor Binding , Pathogenesis and Transmissibility of the 2009 Pandemic H 1 N 1 Influenza Virus

N. Cox, T. Tumpey, R. Sasisekharan, 2011 .

Pathogenesis and Transmission of Triple-Reassortant Swine H1N1 Influenza Viruses Isolated before the 2009 H1N1 Pandemic

T. Tumpey, S. Zaki, J. Katz, 2010, Journal of Virology.

The 2009 Pandemic H1N1 and Triple-Reassortant Swine H1N1 Influenza Viruses Replicate Efficiently but Elicit an Attenuated Inflammatory Response in Polarized Human Bronchial Epithelial Cells

T. Tumpey, J. Katz, H. Zeng, 2010, Journal of Virology.

Pathogenesis of Pandemic Influenza A (H1N1) and Triple-Reassortant Swine Influenza A (H1) Viruses in Mice

T. Tumpey, J. Katz, T. Maines, 2010, Journal of Virology.

The 2009 Pandemic H 1 N 1 and Triple-Reassortant Swine H 1 N 1 Influenza Viruses Replicate Efficiently but Elicit an Attenuated Inflammatory Response in Polarized Human Bronchial Epithelial Cells

T. Tumpey, J. Katz, H. Zeng, 2010 .

Pathogenesis of Avian Influenza (H7) Virus Infection in Mice and Ferrets: Enhanced Virulence of Eurasian H7N7 Viruses Isolated from Humans

T. Tumpey, R. Donis, J. Katz, 2007, Journal of Virology.

Cytokine and Chemokine Profiles in Lung Tissues from Fatal Cases of 2009 Pandemic Influenza A (H1N1)

R. Gao, Y. Shu, T. Tumpey, 2013, The American Journal of Pathology.

Transmission and Pathogenesis of Swine-Origin 2009 A ( H 1 N 1 ) Influenza Viruses in Ferrets and Mice Citation

Rahul Raman, Zachary, Hui Zeng, 2010 .

An avian influenza H7 DNA priming vaccine is safe and immunogenic in a randomized phase I clinical trial

J. Mascola, R. Koup, R. Bailer, 2017, npj Vaccines.

Phase 1 Study of Pandemic H1 DNA Vaccine in Healthy Adults

J. Mascola, R. Koup, G. Nabel, 2015, PloS one.

Diagnostic Approach for Differentiating Infected from Vaccinated Poultry on the Basis of Antibodies to NS1, the Nonstructural Protein of Influenza A Virus

David E. Swayne, T. Tumpey, D. Suarez, 2005, Journal of Clinical Microbiology.

Lack of transmission of H5N1 avian–human reassortant influenza viruses in a ferret model

N. Cox, K. Subbarao, Y. Matsuoka, 2006, Proceedings of the National Academy of Sciences.

The eyes have it: influenza virus infection beyond the respiratory tract.

T. Tumpey, T. Maines, J. Belser, 2018, The Lancet. Infectious diseases.

Effect of Priming With Seasonal Influenza A(H3N2) Virus on the Prevalence of Cross-Reactive Hemagglutination-Inhibition Antibodies to Swine-Origin A(H3N2) Variants

Xiyan Xu, T. Tumpey, J. Katz, 2017, The Journal of infectious diseases.

Molecular correlates of influenza A H5N1 virus pathogenesis in mice.

M. Shaw, K. Subbarao, T. Tumpey, 2001, Journal of virology.

The 1918 flu, 100 years later

T. Tumpey, J. Belser, 2018, Science.

Receptor Specificity and Transmission of H2N2 Subtype Viruses Isolated from the Pandemic of 1957

T. Tumpey, R. Sasisekharan, J. Katz, 2010, PloS one.

Early Control of H5N1 Influenza Virus Replication by the Type I Interferon Response in Mice

Y. Matsuoka, Hualan Chen, T. Tumpey, 2009, Journal of Virology.

Response in Mice Replication by the Type I Interferon Early Control of H5n1 Influenza Virus

Y. Matsuoka, Hualan Chen, T. Tumpey, 2008 .

Role of H7 hemagglutinin in murine infectivity of influenza viruses following ocular inoculation.

T. Tumpey, Li-mei Chen, T. Maines, 2017, Virology.

Risk Assessment of Fifth-Wave H7N9 Influenza A Viruses in Mammalian Models

T. Tumpey, W. Shieh, T. Maines, 2018, Journal of Virology.

Protection against H1, H5, H6 and H9 influenza A infection with liposomal matrix 2 epitope vaccines.

T. Tumpey, H. J. Kim, J. Adler-Moore, 2006, Vaccine.

A plant-produced H1N1 trimeric hemagglutinin protects mice from a lethal influenza virus challenge

Hong Bi, Xiangjie Sun, T. Tumpey, 2013, Human vaccines & immunotherapeutics.

Kinetics and magnitude of viral RNA shedding as indicators for Influenza A virus transmissibility in ferrets

T. Tumpey, T. Maines, J. Belser, 2023, Communications Biology.

Utility of Human In Vitro Data in Risk Assessments of Influenza A Virus Using the Ferret Model

Troy J. Kieran, C. Beauchemin, T. Tumpey, 2023, Journal of virology.

Pathogenesis and Transmissibility of North American Highly Pathogenic Avian Influenza A(H5N1) Virus in Ferrets

T. Tumpey, T. Maines, J. Belser, 2022, Emerging infectious diseases.

Asparagine Substitution at PB2 Residue 701 Enhances the Replication, Pathogenicity, and Transmission of the 2009 Pandemic H1N1 Influenza A Virus

T. Tumpey, M. Pearce, R. Mason, 2013, PloS one.

Pathogenesis, Transmissibility, and Ocular Tropism of a Highly Pathogenic Avian Influenza A (H7N3) Virus Associated with Human Conjunctivitis

C. Davis, N. Cox, T. Tumpey, 2013, Journal of Virology.

Local innate immune responses and influenza virus transmission and virulence in ferrets.

T. Tumpey, J. Katz, T. Maines, 2012, The Journal of infectious diseases.

A Single Base-Pair Change in 2009 H1N1 Hemagglutinin Increases Human Receptor Affinity and Leads to Efficient Airborne Viral Transmission in Ferrets

T. Tumpey, Z. Shriver, R. Sasisekharan, 2011, PloS one.

Virus-like particles displaying H5, H7, H9 hemagglutinins and N1 neuraminidase elicit protective immunity to heterologous avian influenza viruses in chickens.

T. Tumpey, D. Kapczynski, K. Chrzastek, 2017, Virology.

Innovations in modeling influenza virus infections in the laboratory

T. Tumpey, J. Katz, T. Maines, 2012, Trends in Microbiology.

Cross-Reactive Antibody Responses to Novel H5Nx Influenza Viruses Following Homologous and Heterologous Prime-Boost Vaccination with a Prepandemic Stockpiled A(H5N1) Vaccine in Humans

T. Tumpey, J. Katz, A. Bellamy, 2017, The Journal of infectious diseases.

Influenza Virus H5 DNA Vaccination Is Immunogenic by Intramuscular and Intradermal Routes in Humans

J. Mascola, R. Koup, G. Nabel, 2012, Clinical and Vaccine Immunology.

Transmission Studies Resume for Avian Flu

Y. Guan, R. Webster, R. Webby, 2013, Science.

Pause on Avian Flu Transmission Research

John Steel, Paul G. Thomas, Yi Guan, 2012, Science.

2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models

Heinz Feldmann, Nicolas Tchitchek, M. Katze, 2012, BMC Genomics.

Associated with Lethal Outcome in Mice Reminiscent of 1918 Influenza Virus and Is Transcriptomic Signature That Is Viruses Elicit a Three-Pronged H 7 N 9 and Other Pathogenic Avian Influenza

N. Tchitchek, T. Tumpey, J. Belser, 2014 .

Mucosal vaccination protects mice against influenza A heterosubtypic challenge

T. Tumpey, J. Katz, J. Clements, 2001 .

Development of a high-throughput assay to detect antibody inhibition of low pH induced conformational changes of influenza virus hemagglutinin

T. Tumpey, D. Steinhauer, P. Carney, 2018, PloS one.

Pandemic H1N1 2009 and Drug Resistant Influenza Viruses are Potently Inhibited by DAS181, a Sialidase Fusion Protein

Fang Fang, Vasiliy P. Mishin, Larisa V. Gubareva, 2009 .

Infection of lung epithelial cells with pandemic 2009 A(H1N1) influenza viruses reveals isolate-specific differences in infectivity and host cellular responses.

T. Tumpey, S. Tripathi, J. Katz, 2011, Viral immunology.

Human antibodies that neutralize respiratory droplet transmissible H5N1 influenza viruses.

Jens Meiler, James E Crowe, David P Nannemann, 2013, The Journal of clinical investigation.

Infection of Cultured Mammalian Cells with Aerosolized Influenza Virus.

T. Tumpey, T. Maines, J. Belser, 2018, Methods in molecular biology.

Repeated vaccination against matched H3N2 influenza virus gives less protection than single vaccination in ferrets

Xiyan Xu, T. Tumpey, W. Shieh, 2019, npj Vaccines.

Detection and Characterization of Clade 1 Reassortant H5N1 Viruses Isolated from Human Cases in Vietnam during 2013

C. Davis, S. Lindstrom, L. Gubareva, 2015, PloS one.

NS-based live attenuated H 1 N 1 pandemic vaccines protect mice and ferrets ZHOU

A. García-Sastre, T. Tumpey, Bin Zhou, 2017 .

Corrigendum: Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors

Lucy A. Perrone, I. Wilson, E. Altschuler, 2012, Nature.

Past, Present, and Possible Future Human Infection with Influenza Virus A Subtype H7

C. Bridges, T. Tumpey, J. Katz, 2009, Emerging Infectious Diseases.

Influenza Pandemic Virus Characterization of the Reconstructed 1918 Spanish

T. Tumpey, 2009 .

Transforming Growth Factor-β: Activation by Neuraminidase and Role in Highly Pathogenic H5N1 Influenza Pathogenesis

E. Turpin, Jeremy C. Jones, T. Tumpey, 2010, PLoS Pathogens.

Enhanced fitness of SARS-CoV-2 B.1.617.2 Delta variant in ferrets

Troy J. Kieran, T. Tumpey, T. Maines, 2023, Virology.

DNA Vaccine Expressing Conserved Influenza Virus Proteins Protective Against H5N1 Challenge Infection in Mice

K. Subbarao, T. Tumpey, J. Katz, 2002, Emerging Infectious Diseases.

Past, Present, and Possible Future Human Infection with Influenza Virus A Subtype H7

C. Bridges, T. Tumpey, J. Belser, 2009, Emerging Infectious Diseases.

drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication

L. Gubareva, P. Ranjan, A. García-Sastre, 2010 .

Heterologous prime-boost with A(H5N1) pandemic influenza vaccines induces broader cross-clade antibody responses than homologous prime-boost

T. Tumpey, J. Stevens, B. Innis, 2019, npj Vaccines.

5'PPP-RNA induced RIG-I activation inhibits drug-resistant avian H5N1 as well as 1918 and 2009 pandemic influenza virus replication.

L. Gubareva, P. Ranjan, A. García-Sastre, 2010, Virology journal.

Implication of Inflammatory Macrophages, Nuclear Receptors, and Interferon Regulatory Factors in Increased Virulence of Pandemic 2009 H1N1 Influenza A Virus after Host Adaptation

Stewart T. Chang, M. Katze, T. Tumpey, 2012, Journal of Virology.

Reconstruction of the 1918 pandemic influenza virus: how revealing the molecular secrets of the virus responsible for the worst pandemic in recorded history can guide our response to future influenza pandemics.

Lucy A. Perrone, T. Tumpey, 2007, Infectious disorders drug targets.

Inducible nitric oxide contributes to viral pathogenesis following highly pathogenic influenza virus infection in mice.

Lucy A. Perrone, T. Tumpey, J. Belser, 2013, The Journal of infectious diseases.

Early Control of H5N1 Influenza Virus Replication by the Type I Interferon Response in Mice

Y. Matsuoka, Hualan Chen, T. Tumpey, 2009, Journal of Virology.

Simvastatin and oseltamivir combination therapy does not improve the effectiveness of oseltamivir alone following highly pathogenic avian H5N1 influenza virus infection in mice.

T. Tumpey, Kristy J. Szretter, J. Belser, 2013, Virology.

2009 pandemic H1N1 influenza virus elicits similar clinical course but differential host transcriptional response in mouse, macaque, and swine infection models

M. Katze, N. Tchitchek, T. Tumpey, 2012, BMC Genomics.

Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza H5N1 viruses.

N. Cox, T. Tumpey, J. Paulson, 2011, Virology.

Assessment of transmission, pathogenesis and adaptation of H2 subtype influenza viruses in ferrets.

T. Tumpey, Hua Yang, P. Carney, 2015, Virology.

A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus Hemagglutinin

J. Crowe, Jens C. Krause, T. Tumpey, 2011, Journal of Virology.

Transforming Growth Factor-β: Activation by Neuraminidase and Role in Highly Pathogenic H5N1 Influenza Pathogenesis

Jeremy C. Jones, T. Tumpey, J. Gauldie, 2010, PLoS pathogens.

Pandemic Virus Characterization of the Reconstructed 1918 Spanish Influenza

N. Cox, J. Taubenberger, A. García-Sastre, 2012 .

Local innate immune responses and influenza virus transmission and virulence in ferrets.

T. Tumpey, T. Maines, J. Belser, 2012, The Journal of infectious diseases.

Human Pulmonary Microvascular Endothelial Cells Support Productive Replication of Highly Pathogenic Avian Influenza Viruses: Possible Involvement in the Pathogenesis of Human H5N1 Virus Infection

T. Tumpey, J. Belser, H. Zeng, 2011, Journal of Virology.

Ocular Tropism of Influenza A Viruses: Identification of H7 Subtype-Specific Host Responses in Human Respiratory and Ocular Cells

T. Tumpey, J. Belser, H. Zeng, 2011, Journal of Virology.

Pathogenesis, Transmissibility, and Ocular Tropism of a Highly Pathogenic Avian Influenza A (H7N3) Virus Associated with Human Conjunctivitis

C. Davis, N. Cox, T. Tumpey, 2013, Journal of Virology.

Mice lacking both TNF and IL-1 receptors exhibit reduced lung inflammation and delay in onset of death following infection with a highly virulent H5N1 virus.

Lucy A. Perrone, T. Tumpey, Kristy J. Szretter, 2010, The Journal of infectious diseases.