J. Iovanna

发表

TP53INP1s and Homeodomain-interacting Protein Kinase-2 (HIPK2) Are Partners in Regulating p53 Activity*

Daniel Isnardon, Bernard Malissen, Richard Tomasini, 2003, Journal of Biological Chemistry.

P53-dependent expression of the stress-induced protein (SIP).

Richard Tomasini, R. Tomasini, A. A. Samir, 2002, European journal of cell biology.

Deficiency of the Transcriptional Regulator p8 Results in Increased Autophagy and Apoptosis, and Causes Impaired Heart Function

S. Goruppi, J. Iovanna, D. Kong, 2010, Molecular biology of the cell.

The pancreatitis‐associated protein induces lung inflammation in the rat through activation of TNFα expression in hepatocytes

J. Dagorn, J. Iovanna, E. Folch-Puy, 2003, The Journal of pathology.

Expression of the Cdx1 and Cdx2 Homeotic Genes Leads to Reduced Malignancy in Colon Cancer-derived Cells*

J. Dagorn, J. Iovanna, G. Mallo, 1998, The Journal of Biological Chemistry.

ZZW-115–dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2020, JCI insight.

Stratification and therapeutic potential of PML in metastatic breast cancer

C. Caldas, O. Rueda, J. Baselga, 2016, Nature Communications.

Vemurafenib Potently Induces Endoplasmic Reticulum Stress–Mediated Apoptosis in BRAFV600E Melanoma Cells

D. Schadendorf, K. Flaherty, C. Busch, 2013, Science Signaling.

Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E

M. Gleave, L. Fazli, F. Bladou, 2010, Oncogene.

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

Asha Nair, Gavin R. Oliver, Mira Ayadi, 2018, Nature Communications.

Guidelines for the use and interpretation of assays for monitoring autophagy

Robert Clarke, Hong Jiang, Hiroyuki Ishida, 2012 .

Cloning and Expression of the Rat p8 cDNA, a New Gene Activated in Pancreas during the Acute Phase of Pancreatitis, Pancreatic Development, and Regeneration, and Which Promotes Cellular Growth*

J. Iovanna, E. Calvo, G. Mallo, 1997, The Journal of Biological Chemistry.

Expression of p8 in human pancreatic cancer.

J. Iovanna, S. Su, K. Ohtsubo, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

p8 is critical for tumour development induced by rasV12 mutated protein and E1A oncogene

J. Dagorn, J. Iovanna, S. Garcia, 2002, EMBO reports.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

The regenerating family member 3 β instigates IL-17A-mediated neutrophil recruitment downstream of NOD1/2 signalling for controlling colonisation resistance independently of microbiota community structure

B. Ryffel, M. Chamaillard, H. Sokol, 2018, Gut.

Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8.

S. Goruppi, J. Iovanna, S. P. Georgescu, 2011, American journal of physiology. Cell physiology.

Cellular Stress in Acute Pancreatitis

J. Iovanna, 2009 .

Acute-phase reaction of the pancreas

J. Iovanna, C. Archange, J. Nowak, 2008 .

A novel mammalian trans-membrane protein reveals an alternative initiation pathway for autophagy

J. Iovanna, M. Vaccaro, D. Grasso, 2008, Autophagy.

The Pancreatitis-induced Vacuole Membrane Protein 1 Triggers Autophagy in Mammalian Cells*

J. Iovanna, M. Vaccaro, D. Grasso, 2007, Journal of Biological Chemistry.

Analysis of Germline Gene Copy Number Variants of Patients with Sporadic Pancreatic Adenocarcinoma Reveals Specific Variations

Massimo Midiri, Giuseppe Lo Re, Giuseppe Cicero, 2013, Oncology.

Analysis of 2166 clones from a human colorectal cancer cDNA library by partial sequencing.

J. Dagorn, J. Iovanna, J. Frigerio, 1995, Human molecular genetics.

PAP I interacts with itself, PAP II, PAP III, and lithostathine/regIalpha.

J. Dagorn, J. Iovanna, V. Keim, 1999, Molecular cell biology research communications : MCBRC.

Exploring the Complementarity of Pancreatic Ductal Adenocarcinoma Preclinical Models

S. Boyault, J. Iovanna, N. Dusetti, 2021, Cancers.

Evidencing a Pancreatic Ductal Adenocarcinoma Subpopulation Sensitive to the Proteasome Inhibitor Carfilzomib

J. Iovanna, N. Dusetti, P. Santofimia-Castaño, 2020, Clinical Cancer Research.

Epigenetics of gastrointestinal diseases: notes from a workshop

D. Iliopoulos, N. Ahuja, M. Fabbri, 2018, Epigenetics.

Speeding towards individualized treatment for pancreatic cancer by taking an alternative road.

J. Iovanna, N. Dusetti, 2017, Cancer letters.

Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis

J. Iovanna, N. Dusetti, C. Cano, 2013, Gut.

Toll-like receptor 2 is critical for induction of Reg3β expression and intestinal clearance of Yersinia pseudotuberculosis

S. Akira, J. Sirard, B. Ryffel, 2009, Gut.

Yersinia pseudotuberculosis Reg3² expression and intestinal clearance of Toll-like receptor 2 is critical for induction of

S. Akira, H. Sokol, J. Iovanna, 2009 .

Pancreatic Cancer Genetics

J. Dagorn, J. Iovanna, N. Dusetti, 2012 .

Self-assembling supramolecular dendrimer nanosystem for PET imaging of tumors

Sabrina Pricl, Benjamin Guillet, Philippe Garrigue, 2018, Proceedings of the National Academy of Sciences.

Relevance of biopsy-derived pancreatic organoids in the development of efficient transcriptomic signatures to predict adjuvant chemosensitivity in pancreatic cancer

J. Iovanna, N. Dusetti, J. Emile, 2021, Translational oncology.

Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer

J. Iovanna, N. Dusetti, L. Buscail, 2020, bioRxiv.

Establishment of a pancreatic adenocarcinoma molecular gradient (PAMG) that predicts the clinical outcome of pancreatic cancer

J. Iovanna, N. Dusetti, L. Buscail, 2020, EBioMedicine.

α‐lipoic acid reduces postreperfusion syndrome in human liver transplantation ‐ a pilot study

J. Iovanna, P. Santofimia-Castaño, A. Gadano, 2018, Transplant international : official journal of the European Society for Organ Transplantation.

SMAP: exploiting high-throughput sequencing data of patient derived xenografts

J. Iovanna, N. Dusetti, A. de Reyniès, 2018, bioRxiv.

Diagnostic, prognostic and therapeutic value of gene signatures

S. Iacobelli, A. Russo, J. Iovanna, 2012 .

Basal-like and Classical cells coexistence in pancreatic cancer revealed by single cell analysis

J. Iovanna, N. Dusetti, R. Nicolle, 2020, bioRxiv.

Basal‐like and classical cells coexist in pancreatic cancer revealed by single‐cell analysis on biopsy‐derived pancreatic cancer organoids from the classical subtype

J. Iovanna, N. Dusetti, R. Nicolle, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Determinants of the pKa values of ionizable residues in an intrinsically disordered protein.

J. Iovanna, J. Neira, B. Rizzuti, 2016, Archives of biochemistry and biophysics.

Single and combinatorial chromatin coupling events underlies the function of transcript factor krüppel-like factor 11 in the regulation of gene networks

J. Iovanna, G. Lomberk, R. Urrutia, 2014, BMC Molecular Biology.

Dynamics of the intrinsically disordered protein NUPR1 in isolation and in its fuzzy complexes with DNA and prothymosin α.

M. Ortore, J. Iovanna, J. Neira, 2019, Biochimica et biophysica acta. Proteins and proteomics.

Combined Targeting of G9a and Checkpoint Kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse

J. Iovanna, N. Dusetti, T. D. de Assunção, 2019, Molecular Cancer Research.

Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death

S. Goruppi, A. Carracedo, J. Dagorn, 2012, Clinical Cancer Research.

p8 Expression controls pancreatic cancer cell migration, invasion, adhesion, and tumorigenesis

J. Dagorn, J. Iovanna, C. Cano, 2011, Journal of cellular physiology.

Oxidative stress-induced p53 activity is enhanced by a redox-sensitive TP53INP1 SUMOylation

J. Iovanna, N. Dusetti, P. Soubeyran, 2014, Cell Death and Differentiation.

Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma

O. Abián, A. Velázquez‐Campoy, Á. Lanas, 2017, Scientific Reports.

Clinical Evaluation of Pancreatitis-Associated Protein as a Serum Marker of Hepatocellular Carcinoma: Comparison with α-Fetoprotein

J. Dagorn, J. Iovanna, N. Dusetti, 1998, Oncology.

Deciphering the cellular source of tumor relapse identifies CD44 as a major therapeutic target in pancreatic adenocarcinoma

J. Iovanna, N. Dusetti, S. Garcia, 2015, Oncotarget.

Messenger RNA sequence and expression of rat pancreatitis-associated protein, a lectin-related protein overexpressed during acute experimental pancreatitis.

J. Dagorn, J. Iovanna, V. Keim, 1991, The Journal of biological chemistry.

Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases.

J. Dagorn, J. Iovanna, V. Keim, 1992, The Journal of clinical investigation.

Reg-2 is a motoneuron neurotrophic factor and a signalling intermediate in the CNTF survival pathway

C. Henderson, J. Iovanna, S. Wiese, 2000, Nature Cell Biology.

p8 Improves Pancreatic Response to Acute Pancreatitis by Enhancing the Expression of the Anti-inflammatory Protein Pancreatitis-associated Protein I*

M. Lerch, J. Dagorn, J. Iovanna, 2004, Journal of Biological Chemistry.

Absence of tumor suppressor tumor protein 53-induced nuclear protein 1 (TP53INP1) sensitizes mouse thymocytes and embryonic fibroblasts to redox-driven apoptosis.

A. Carrier, J. Iovanna, N. Dusetti, 2011, Antioxidants & redox signaling.

Methodological aspects of the molecular and histological study of prostate cancer: Focus on PTEN

C. Cordon-Cardo, J. Baselga, J. Tabernero, 2015, Methods.

Colitis and Colitis-Associated Cancer Are Exacerbated in Mice Deficient for Tumor Protein 53-Induced Nuclear Protein 1

Bernard Malissen, Juan Iovanna, A. Carrier, 2007, Molecular and Cellular Biology.

Redox-sensitive TP53INP1 SUMOylation as an oxidative stress sensor to activate TP53

J. Iovanna, N. Dusetti, P. Soubeyran, 2014, Molecular & cellular oncology.

Development of an ELISA detecting Tumor Protein 53-Induced Nuclear Protein 1 in serum of prostate cancer patients.

A. Carrier, J. Iovanna, N. Dusetti, 2013, Results in immunology.

Meaning of tumor protein 53-induced nuclear protein 1 in the molecular mechanism of gemcitabine sensitivity.

J. Iovanna, N. Dusetti, N. Nakaya, 2013, Molecular and clinical oncology.

TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death

C. Gauthier, A. Carrier, J. Iovanna, 2012, Cell Death and Differentiation.

53-induced nuclear protein 1 (TP53INP1), are important factors in the invasion and metastasis of pancreatic cancer. TP53INP1 is a pro-apoptotic factor and is transcriptionally regulated in p53-dependent and -independent manners. A previous study proved that gemcitabine induces TP53INP1 expression in

J. Iovanna, N. Dusetti, N. Nakaya, 2012 .

TP53INP1 decreases pancreatic cancer cell migration by regulating SPARC expression

A. Carrier, J. Iovanna, N. Dusetti, 2011, Oncogene.

TP53INP1 (tumor protein p53 inducible nuclear protein 1)

A. Carrier, J. Iovanna, N. Dusetti, 2011 .

Tumor Protein p53-Induced Nuclear Protein (TP53INP1) Expression in Medullary Thyroid Carcinoma: A Molecular Guide to the Optimal Extent of Surgery?

J. Iovanna, N. Dusetti, F. Sebag, 2010, World Journal of Surgery.

Tumor protein 53-induced nuclear protein 1 is a major mediator of p53 antioxidant function.

A. Carrier, J. Iovanna, N. Dusetti, 2009, Cancer research.

Tumor protein p53-induced nuclear protein 1 (TP53INP1) in spontaneous chronic pancreatitis in the WBN/Kob rat: drug effects on its expression in the pancreas.

J. Iovanna, M. Pébusque, N. Sawabu, 2004, JOP : Journal of the pancreas.

Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer.

J. Iovanna, M. Pébusque, S. Garcia, 2006, World journal of gastroenterology.

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells.

P. Pandolfi, P. Boya, F. Cecconi, 2009, The Journal of clinical investigation.

TRB3 links ER stress to autophagy in cannabinoid antitumoral action

P. Boya, A. Carracedo, J. Iovanna, 2009, Autophagy.

Apoptosis in BRAFV600E Melanoma Cells Vemurafenib Potently Induces Endoplasmic Reticulum Stress-Mediated `

D. Schadendorf, K. Flaherty, C. Busch, 2013 .

Evidence supporting the existence of a NUPR1-like family of helix-loop-helix chromatin proteins related to, yet distinct from, AT hook-containing HMG proteins

J. Iovanna, J. Neira, R. Urrutia, 2014, Journal of Molecular Modeling.

Functional impact of Aurora A-mediated phosphorylation of HP1γ at serine 83 during cell cycle progression

J. Iovanna, G. Lomberk, R. Urrutia, 2013, Epigenetics & Chromatin.

The human NUPR1/P8 gene is transcriptionally activated by transforming growth factor β via the SMAD signalling pathway.

G. Fourel, J. Iovanna, C. Cano, 2012, The Biochemical journal.

E-cadherin is a structuring component of invadopodia in pancreatic cancer

J. Iovanna, N. Dusetti, F. André, 2020, bioRxiv.

Induction of antioxidant mechanisms in lung during experimental pancreatitis in rats

J. Iovanna, H. Rechreche, A. Abbes, 2020, Indian Journal of Experimental Biology.

p8 Is a New Target of Gemcitabine in Pancreatic Cancer Cells

J. Dagorn, J. Iovanna, M. Barthet, 2006, Clinical Cancer Research.

Factors released by the tumor far microenvironment are decisive for pancreatic adenocarcinoma development and progression

J. Iovanna, D. Closa, 2017, Oncoimmunology.

Stress Response Gene Nupr1 Alleviates Cyclosporin A Nephrotoxicity In Vivo.

J. Iovanna, E. Rondeau, N. Bigé, 2017, Journal of the American Society of Nephrology : JASN.

Iron-Sensitive Prodrugs That Trigger Active Ferroptosis in Drug-Tolerant Pancreatic Cancer Cells.

A. Puisieux, J. Iovanna, N. Dusetti, 2022, Journal of the American Chemical Society.

Genetic alterations in precancerous pancreatic lesions and their clinical implications.

J. Dagorn, J. Iovanna, C. Cano, 2009, Gastroenterologie clinique et biologique.

Deciphering the Crosstalk Between Myeloid-Derived Suppressor Cells and Regulatory T Cells in Pancreatic Ductal Adenocarcinoma

S. A. van de Pavert, Anna R Martirosyan, J. Iovanna, 2020, Frontiers in Immunology.

IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer.

P. Dubus, J. Iovanna, G. Lomberk, 2015, Cancer research.

Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation

J. Iovanna, G. Lomberk, R. Urrutia, 2015, Scientific Reports.

Gene expression profiling by DNA microarray analysis in mouse embryonic fibroblasts transformed by ras V 12 mutated protein and the E 1 A oncogene

J. Dagorn, J. Iovanna, C. Labrie, 2006 .

Tumor necrosis factor alpha triggers antiapoptotic mechanisms in rat pancreatic cells through pancreatitis-associated protein I activation.

J. Dagorn, J. Iovanna, N. Dusetti, 2000, Gastroenterology.

Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma

R. Tomasini, J. Iovanna, G. Bidaut, 2015, Proceedings of the National Academy of Sciences.

Overexpression of Cdx1 and Cdx2 homeogenes enhances expression of the HLA-I in HT-29 cells.

J. Dagorn, J. Iovanna, G. Mallo, 2000, Molecular cell biology research communications : MCBRC.

Dissecting the Anticancer Mechanism of Trifluoperazine on Pancreatic Ductal Adenocarcinoma

J. Iovanna, P. Santofimia-Castaño, Wenjun Lan, 2019, Cancers.

Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes.

Arkaitz Carracedo, A. Carracedo, J. Iovanna, 2006, Cancer research.

Nupr1: The Swiss‐knife of cancer

J. Iovanna, C. Cano, M. Sandí, 2011, Journal of cellular physiology.

p8/nupr1 regulates DNA‐repair activity after double‐strand gamma irradiation‐induced DNA damage

J. Dagorn, J. Iovanna, J. Neira, 2009, Journal of cellular physiology.

The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells.

M. Piris, A. Carracedo, J. Iovanna, 2006, Cancer cell.

Research p 8 inhibits the growth of human pancreatic cancer cells and its expression is induced through pathways involved in growth inhibition and repressed by factors promoting cell growth

J. Iovanna, S. Vasseur, N. Lesavre, 2016 .

Gene expression profiling of patient‐derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts

J. Qi, J. Bradner, J. Iovanna, 2017, EMBO molecular medicine.

Expression of POU2F3 Transcription Factor Control Inflammation, Immunological Recruitment and Metastasis of Pancreatic Cancer in Mice

J. Iovanna, P. Jay, N. Auphan-Anezin, 2020, Biology.

Deficiency of stress‐associated gene Nupr1 increases bone volume by attenuating differentiation of osteoclasts and enhancing differentiation of osteoblasts

M. Mawatari, J. Iovanna, A. Kukita, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Functional Characterization of Nupr1L, A Novel p53‐Regulated Isoform of the High‐Mobility Group (HMG)‐Related Protumoral Protein Nupr1

J. Iovanna, J. Neira, G. Lomberk, 2015, Journal of cellular physiology.

Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway

S. Brimijoin, A. Windebank, J. Iovanna, 2018, Scientific Reports.

Sequence-specific Recruitment of Heterochromatin Protein 1 via Interaction with Krüppel-like Factor 11, a Human Transcription Factor Involved in Tumor Suppression and Metabolic Diseases

Sumera H Rizvi, N. Buttar, J. Iovanna, 2012, The Journal of Biological Chemistry.

Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization

M. Mattei, R. Tomasini, J. Dagorn, 2002, Cytogenetic and Genome Research.

Surface Charge of Supramolecular Nanosystems for In Vivo Biodistribution: A MicroSPECT/CT Imaging Study.

E. Laurini, D. Marson, S. Pricl, 2020, Small.

Novel triazole nucleoside analogues promote anticancer activity via both apoptosis and autophagy.

J. Iovanna, Ling Peng, Xiaoxuan Liu, 2020, Chemical communications.

Flavonoid-alkylphospholipid conjugates elicit dual inhibition of cancer cell growth and lipid accumulation.

J. Iovanna, Ling Peng, Wenjun Lan, 2019, Chemical communications.

PAP/HIP Protein Is an Obesogenic Factor

L. Christa, J. Iovanna, N. Dusetti, 2014, Journal of cellular physiology.

Immunocytochemical localization of pancreatitis-associated protein in human small intestine

J. Dagorn, J. Iovanna, N. Dusetti, 1995, Digestive Diseases and Sciences.

Diurnal changes in actin mRNA levels and incorporation of35S-methionine into actin in the rat hypothalamus

D. Cardinali, J. Iovanna, N. Dusetti, 1990, Cellular and Molecular Neurobiology.

VMP1 Expression Correlates with Acinar Cell Cytoplasmic Vacuolization in Arginine-Induced Acute Pancreatitis

J. Iovanna, M. Vaccaro, D. Grasso, 2003, Pancreatology.

Lipopolysaccharides induce p8 mRNA expression in vivo and in vitro.

J. Iovanna, E. Calvo, M. Vaccaro, 1999, Biochemical and biophysical research communications.

Overexpression of the PC3/TIS21/BTG2 mRNA is part of the stress response induced by acute pancreatitis in rats.

J. Dagorn, J. Iovanna, G. Mallo, 1998, Biochemical and biophysical research communications.

Pancreatitis-Associated Protein Is Upregulated in Mouse Pancreas during Acute Pancreatitis

J. Dagorn, J. Iovanna, V. Keim, 1998, Digestion.

Presence of Pancreatitis‐Associated Protein in Pancreatic Acinar Cells of Rats Treated with Chlorophenylalanine Methyl Ester

J. Dagorn, J. Iovanna, E. Calvo, 1996, Pancreas.

Developmental, nutritional, and hormonal regulation of the pancreatitis-associated protein I and III gene expression in the rat small intestine.

J. Dagorn, J. Iovanna, N. Dusetti, 1995, Scandinavian journal of gastroenterology.

LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma

F. Bertucci, P. Finetti, R. Tomasini, 2021, Communications Biology.

Targeting Mitochondrial Complex I Overcomes Chemoresistance in High OXPHOS Pancreatic Cancer

E. Pasquier, A. Carrier, J. Iovanna, 2020, Cell reports. Medicine.

TAp73 loss favors Smad-independent TGF-β signaling that drives EMT in pancreatic ductal adenocarcinoma

R. Tomasini, J. Iovanna, S. Vasseur, 2016, Cell Death and Differentiation.

Reduced nuclear protein 1 expression improves insulin sensitivity and protects against diet-induced glucose intolerance through up-regulation of heat shock protein 70.

J. Iovanna, P. Jones, S. Persaud, 2015, Biochimica et biophysica acta.

Regulation of apoptosis by the p8/prothymosin alpha complex.

J. Dagorn, J. Iovanna, J. Neira, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Melatonin modulates metabolic adaptation of pancreatic stellate cells subjected to hypoxia.

J. Iovanna, M. Estaras, A. González, 2022, Biochemical pharmacology.

Effect of reactive oxygen and carbonyl species on crucial cellular antioxidant enzymes.

J. Iovanna, A. Dolla, P. Stocker, 2011, Chemico-biological interactions.

Oligomerization and Phosphorylation Dependent Regulation of ArgBP2 Adaptive Capabilities and Associated Functions

J. Iovanna, E. Ghigo, P. Soubeyran, 2014, PloS one.

9th International Symposium on Resistance Arteries (ISRA)

Blair D. Johnson, J. Paulauskis, M. Chiariello, 2009, Journal of Vascular Research.

Nupr1 deletion protects against glucose intolerance by increasing beta cell mass

Peter M. Jones, J. Iovanna, A. King, 2013, Diabetologia.

Cu-mediated Selective N-arylation of Aminotriazole Acyclonucleosides

J. Iovanna, J. Neyts, Ling Peng, 2009 .

A dietary flavone confers communicable protection against colitis through NLRP6 signaling independently of inflammasome activation

P. Rosenstiel, B. Ryffel, M. Chamaillard, 2017, Mucosal Immunology.

Downregulation of IGF-I mRNA expression during postnatal pancreatic development and overexpression after subtotal pancreatectomy and acute pancreatitis in the rat pancreas.

J. Iovanna, E. Calvo, J. Morisset, 1997, Journal of molecular endocrinology.

NUPR1 protects liver from lipotoxic injury by improving the endoplasmic reticulum stress response

G. Pantuso, J. Iovanna, K. Blyth, 2020, bioRxiv.

Pancreatitis-associated protein protects the lung from leukocyte-induced injury.

J. Iovanna, A. Heller, T. Koch, 1999, Anesthesiology.

1 Disruption of a Novel KLF-p 300-Regulated Pathway for Insulin Biosynthesis Revealed by Studies of the c .331 INS Mutation Found in Neonatal Diabetes Mellitus

U. Hodoğlugil, R. Scharfmann, P. Froguel, 2011 .

CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness

F. Bertucci, P. Finetti, R. Tomasini, 2022, Science Signaling.

A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution.

S. Herzig, J. Iovanna, D. Schmoll, 2016, The Journal of clinical investigation.

Two transcripts are generated from the pancreatitis associated protein II gene by alternative splicing in the 5' untranslated region.

J. Dagorn, J. Iovanna, N. Dusetti, 1995, Biochimica et biophysica acta.

The NUPR1/p73 axis contributes to sorafenib resistance in hepatocellular carcinoma.

J. McCubrey, J. Iovanna, M. Cervello, 2021, Cancer letters.

Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2019, Cells.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Interleukin-22-deficiency and microbiota contribute to the exacerbation of Toxoplasma gondii-induced intestinal inflammation

J. Renauld, B. Ryffel, M. Chamaillard, 2018, Mucosal Immunology.

p97/VCP induces GLI1 to control XBP1-dependent endoplasmic reticulum stress transcriptional response

E. Chevet, J. Iovanna, M. Fernández-Zapico, 2021, bioRxiv.

The chromatin nuclear protein NUPR1L is intrinsically disordered and binds to the same proteins as its paralogue.

M. Vidal, A. Cámara-Artigas, J. Iovanna, 2018, The Biochemical journal.

The clinical impact of an extra virgin olive oil enriched mediterranean diet on metabolic syndrome: Lights and shadows of a nutraceutical approach

J. Iovanna, M. Soresi, M. Cervello, 2022, Frontiers in Nutrition.

Germline copy number variation in the YTHDC2 gene: does it have a role in finding a novel potential molecular target involved in pancreatic adenocarcinoma susceptibility?

A. Russo, V. Bazan, J. Dagorn, 2014, Expert opinion on therapeutic targets.

Peroxisome proliferator-activated receptor gamma agonist reduces the severity of post-ERCP pancreatitis in rats.

J. Iovanna, E. Folch-Puy, D. Closa, 2006, World journal of gastroenterology.

Pancreatic Acinar Cells Submitted to Stress Activate TNF-α Gene Expression

J. Iovanna, E. Calvo, M. Vaccaro, 2000 .

Reg3β deficiency impairs pancreatic tumor growth by skewing macrophage polarization.

J. Iovanna, J. Roselló-Catafau, E. Folch-Puy, 2013, Cancer research.

REG3(cid:2) DEFICIENCY IMPAIRS PANCREATIC TUMOR GROWTH BY SKEWING MACROPHAGE POLARIZATION

J. Iovanna, J. Roselló-Catafau, E. Folch-Puy, 2013 .

Can circulating PD-1, PD-L1, BTN3A1, pan-BTN3As, BTN2A1 and BTLA levels enhance prognostic power of CA125 in patients with advanced high-grade serous ovarian cancer?

D. Olive, S. Vieni, V. Bazan, 2022, Frontiers in Oncology.

Rapid PCR cloning and sequence determination of the rat lithostathine gene.

J. Dagorn, J. Iovanna, N. Dusetti, 1993, Biochimica et biophysica acta.

Optimization of a Bioluminescence Resonance Energy Transfer-Based Assay for Screening of Trypanosoma cruzi Protein/Protein Interaction Inhibitors

J. Iovanna, N. Dusetti, O. Gayet, 2018, Molecular Biotechnology.

Consequences of DJ-1 upregulation following p53 loss and cell transformation

T. Mak, R. Tomasini, J. Iovanna, 2012, Oncogene.

Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction

J. Iovanna, N. Dusetti, G. Lomberk, 2022, npj Precision Oncology.

Novel role of VMP1 as modifier of the pancreatic tumor cell response to chemotherapeutic drugs

J. Iovanna, N. Dusetti, G. Lomberk, 2013, Journal of cellular physiology.

Translatome-based classification reveals a dual metabolic dependency of a new tumor subtype of pancreatic cancer

J. Iovanna, N. Dusetti, O. Larsson, 2020, bioRxiv.

Pancreatitis-associated Protein I (PAP I), an Acute Phase Protein Induced by Cytokines

J. Dagorn, J. Iovanna, N. Dusetti, 1995, The Journal of Biological Chemistry.

Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas.

A. Duval, J. Vaillant, J. Iovanna, 2017, Gastroenterology.

EVOO’s Effects on Incretin Production: Is There a Rationale for a Combination in T2DM Therapy?

J. Iovanna, M. Soresi, A. Licata, 2022, International journal of molecular sciences.

Chloroquine plays a cell-dependent role in the response to treatment of pancreatic adenocarcinoma

J. Iovanna, D. Fanale, M. Swayden, 2018, Oncotarget.

Expression and cellular localization of p8 protein in thyroid neoplasms.

A. Miyauchi, Yasuhiro Ito, Y. Takamura, 2003, Cancer letters.

Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs.

J. Dagorn, J. Iovanna, J. Frigerio, 1995, Biochimica et biophysica acta.

Cloning and expression of the rat vacuole membrane protein 1 (VMP1), a new gene activated in pancreas with acute pancreatitis, which promotes vacuole formation.

R. Tomasini, J. Dagorn, J. Iovanna, 2000, Biochemical and biophysical research communications.

Identification of a second rat pancreatitis-associated protein. Messenger RNA cloning, gene structure, and expression during acute pancreatitis.

J. Dagorn, J. Iovanna, N. Dusetti, 1993, Biochemistry.

IL-22-induced antimicrobial peptides are key determinants of mucosal vaccine-induced protection against H. pylori in mice

J. Renauld, W. Ouyang, J. Iovanna, 2016, Mucosal Immunology.

&agr;-Lipoic Acid Protects Against Ischemia-Reperfusion Injury in Simultaneous Kidney-Pancreas Transplantation

J. Iovanna, Monica B Herrera, N. Ambrosi, 2016, Transplantation.

Expression of the stress-induced p8 mRNA is transiently activated after culture medium change.

J. Dagorn, J. Iovanna, G. Mallo, 2001, European journal of cell biology.

IER 3 supports KRASG 12 D-dependent pancreatic cancer development by sustaining ERK 1 / 2 phosphorylation

R. Tomasini, J. Iovanna, G. Lomberk, 2022 .

Novel triazole ribonucleoside down-regulates heat shock protein 27 and induces potent anticancer activity on drug-resistant pancreatic cancer.

J. Iovanna, Ling Peng, P. Rocchi, 2009, Journal of medicinal chemistry.

Discovery of novel arylethynyltriazole ribonucleosides with selective and effective antiviral and antiproliferative activity.

J. Iovanna, J. Neyts, Jianhua Yao, 2009, Journal of medicinal chemistry.

Expression of Genes Associated with Dedifferentiation and Cell Proliferation During Pancreatic Regeneration Following Acute Pancreatitis

J. Dagorn, J. Iovanna, P. L. de la Porte, 1992, Pancreas.

PAP1 signaling involves MAPK signal transduction

J. Dagorn, J. Iovanna, E. Folch-Puy, 2009, Cellular and Molecular Life Sciences.

Rat Pancreatitis‐Associated Protein Is Expressed in Relation to Severity of Experimental Pancreatitis

J. Dagorn, J. Iovanna, G. Adler, 1994, Pancreas.

The pancreatitis associated protein III (PAP III), a new member of the PAP gene family.

J. Dagorn, J. Iovanna, N. Dusetti, 1993, Biochimica et biophysica acta.

An ionizable supramolecular dendrimer nanosystem for effective siRNA delivery with a favorable safety profile

E. Laurini, D. Marson, S. Pricl, 2020, Nano Research.

Intestinally Secreted C-Type Lectin Reg3b Attenuates Salmonellosis but Not Listeriosis in Mice

M. Chamaillard, R. van der Meer, J. Iovanna, 2012, Infection and Immunity.

FGFR3 has tumor suppressor properties in cells with epithelial phenotype

P. Dubus, S. Dabernat, F. Moreau-Gaudry, 2013, Molecular Cancer.

J. Dagorn, J. Iovanna, S. Rouquier, 1989, The Biochemical journal.

Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression

J. Iovanna, P. Svingen, G. Lomberk, 2013, Epigenetics & Chromatin.

Changes in Growth and Pancreatic mRNA Concentrations During Postnatal Development of Rat Pancreas

J. Iovanna, N. Dusetti, E. Calvo, 1990, Pancreas.

Anti-inflammatory effects of pancreatitis associated protein in inflammatory bowel disease

M. Sans, J. Iovanna, J. Panés, 2005, Gut.

Melatonin controls cell proliferation and modulates mitochondrial physiology in pancreatic stellate cells

J. Iovanna, M. Estaras, M. Fernández-Bermejo, 2022, Journal of Physiology and Biochemistry.

Transcriptional regulation by cholecystokinin-pancreozymin in rat pancreas

J. Dagorn, J. Iovanna, E. Calvo, 1991, Regulatory Peptides.

Blood concentrations of pancreatitis associated protein in neonates: relevance to neonatal screening for cystic fibrosis

J. Sarles, A. Toutain, J. Dagorn, 1999, Archives of disease in childhood. Fetal and neonatal edition.

Regulation of NUB1 Activity through Non-Proteolytic Mdm2-Mediated Ubiquitination

J. Iovanna, S. Audebert, L. Camoin, 2017, PloS one.

Small Activating RNA Modulation of the G Protein‐Coupled Receptor for Cancer Treatment

Jing Wu, J. Iovanna, N. Dusetti, 2022, Advanced science.

Pancreatic changes in TNBS-induced colitis in mice.

J. Dagorn, J. Iovanna, P. Desreumaux, 2003, Gastroenterologie clinique et biologique.

P8 deficiency increases cellular ROS and induces HO-1.

J. Iovanna, J. Mössner, S. Weis, 2015, Archives of Biochemistry and Biophysics.

Autophagy and VMP1 Expression Are Early Cellular Events in Experimental Diabetes

J. Iovanna, M. Vaccaro, D. Grasso, 2008, Pancreatology.

NUPR1 inhibitor ZZW-115 induces ferroptosis in a mitochondria-dependent manner

J. Pouysségur, J. Iovanna, J. Neira, 2021, Cell death discovery.

The Pancreatitis-associated Protein I Promoter Allows Targeting to the Pancreas of a Foreign Gene, Whose Expression Is Up-regulated during Pancreatic Inflammation*

J. Dagorn, J. Iovanna, N. Dusetti, 1997, The Journal of Biological Chemistry.

33rd Annual Meeting of the Pancreatic Society of Great Britain and Ireland. October 30–31, 2008, Derby, UK

D. Sahani, N. Malats, F. Real, 2009, Pancreatology (Print).

33rd Annual Meeting of the Pancreatic Society of Great Britain and Ireland. October 30–31, 2008, Derby, UK

D. Sahani, N. Malats, F. Real, 2009, Pancreatology (Print).

Developmental Regulation of Apolipoprotein B mRNA Editing Is an Autonomous Function of Small Intestine Involving Homeobox Gene Cdx1*

H. Brewer, T. Eggerman, J. Iovanna, 2003, The Journal of Biological Chemistry.

Colitis and Colitis-Associated Cancer Are Exacerbated in Mice Deﬁcient for Tumor Protein 53-Induced Nuclear Protein 1 (cid:1)

A. Carrier, B. Malissen, J. Iovanna, 2007 .

Mechanism of PAP I gene induction during hepatocarcinogenesis: clinical implications.

J. Dagorn, J. Iovanna, N. Dusetti, 1996, British Journal of Cancer.

A novel bitriazolyl acyclonucleoside endowed with dual antiproliferative and immunomodulatory activity.

J. Iovanna, O. Demaria, L. Alexopoulou, 2012, Journal of medicinal chemistry.

TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity

T. Mak, G. Melino, M. Tsao, 2009, Proceedings of the National Academy of Sciences.

Designing and repurposing drugs to target intrinsically disordered proteins for cancer treatment: using NUPR1 as a paradigm

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2019, Molecular & cellular oncology.

Effect of antioxidants on postoperative hyperamylasemia in coronary bypass surgery.

J. Dagorn, J. Iovanna, H. Paajanen, 1996, Pancreas.

Deciphering the Binding of the Nuclear Localization Sequence of Myc Protein to the Nuclear Carrier Importin α3

J. Iovanna, J. Neira, B. Rizzuti, 2022, International journal of molecular sciences.

Effects of hypercholecystokininemia produced by pancreaticobiliary diversion on pancreatic growth and enzyme mRNA levels in starved rats.

J. Dagorn, J. Iovanna, R. Håkanson, 1993, Scandinavian journal of gastroenterology.

Pancreatitis associated protein I (PAP-I) alters adhesion and motility of human melanocytes and melanoma cells.

J. Grob, J. Dagorn, J. Iovanna, 2001, The Journal of investigative dermatology.

Expression of p8 protein in medullary thyroid carcinoma.

A. Miyauchi, Yasuhiro Ito, Y. Takamura, 2005, Anticancer research.

NUPR1 protects against hyperPARylation-dependent cell death

J. Iovanna, J. Neira, P. Santofimia-Castaño, 2022, Communications Biology.

N-aryltriazole ribonucleosides with potent antiproliferative activity against drug-resistant pancreatic cancer.

J. Iovanna, Ling Peng, P. Rocchi, 2010, Bioorganic & medicinal chemistry letters.

Dendrimeric nanosystem consistently circumvents heterogeneous drug response and resistance in pancreatic cancer

Xing-jie Liang, E. Laurini, D. Marson, 2021, Exploration.

Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis.

J. Dagorn, J. Iovanna, H. Sarles, 1989, The Journal of clinical investigation.

Rat pancreatic stone protein messenger RNA. Abundant expression in mature exocrine cells, regulation by food content, and sequence identity with the endocrine reg transcript.

J. Dagorn, J. Iovanna, S. Rouquier, 1991, The Journal of biological chemistry.

Lithostathine, an Inhibitor of CaCO3, Crystal Growth in Pancreatic Juice, Induces Bacterial Aggregation

J. Dagorn, J. Iovanna, N. Dusetti, 1993, Pancreas.

Pancreatitis-associated protein in patients with celiac disease: serum levels and immunocytochemical localization in small intestine.

J. Dagorn, J. Iovanna, G. Iacono, 1997, Digestion.

Identification of a transcriptional regulatory region of the rat pancreatitis-associated protein I (PAP I) gene that confers tissue specificity.

J. Dagorn, J. Iovanna, N. Dusetti, 1995, The Biochemical journal.

The pancreatitis-associated protein (PAP). A new candidate for neonatal screening of cystic fibrosis.

J. Sarles, J. Dagorn, J. Iovanna, 1994, Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie.

Serum levels of pancreatitis-associated protein as indicators of the course of acute pancreatitis. Multicentric Study Group on Acute Pancreatitis.

C. Létoublon, J. Dagorn, J. Iovanna, 1994, Gastroenterology.

PAP, a pancreatic secretory protein induced during acute pancreatitis, is expressed in rat intestine.

J. Dagorn, J. Iovanna, N. Dusetti, 1993, The American journal of physiology.

Structural organization of the gene encoding the rat pancreatitis-associated protein. Analysis of its evolutionary history reveals an ancient divergence from the other carbohydrate-recognition domain-containing genes.

J. Dagorn, J. Iovanna, N. Dusetti, 1993, The Journal of biological chemistry.

The multifunctional family of secreted proteins containing a C-type lectin-like domain linked to a short N-terminal peptide.

J. Dagorn, J. Iovanna, 2005, Biochimica et biophysica acta.

A novel arylethynyltriazole acyclonucleoside inhibits proliferation of drug-resistant pancreatic cancer cells.

J. Iovanna, Ling Peng, P. Rocchi, 2010, Bioorganic & medicinal chemistry letters.

Characterization of a rat pancreatic secretory protein associated with pancreatitis.

K. Usadel, J. Dagorn, J. Iovanna, 1991, Gastroenterology.

A novel exocrine protein associated with pancreas transplantation in humans.

J. Dagorn, J. Iovanna, U. Hopt, 1992, Gastroenterology.

pap, reg Iα and reg Iβ mRNAs are concomitantly up‐regulated during human colorectal carcinogenesis

J. Dagorn, J. Iovanna, G. Montalto, 1999 .

Cdx1 promotes cellular growth of epithelial intestinal cells through induction of the secretory protein PAP I.

J. Dagorn, J. Iovanna, N. Dusetti, 2001, European journal of cell biology.

Increased serum pancreatitis associated protein (PAP) concentration after longterm alcohol consumption: further evidence for regular subclinical pancreatic damage after heavy drinking?

J. Dagorn, J. Iovanna, I. Nordback, 1995, Gut.

Pancreatic gene expression is altered during acute experimental pancreatitis in the rat.

J. Dagorn, J. Iovanna, V. Keim, 1991, The American journal of physiology.

Pancreatitis-associated protein: from a lectin to an anti-inflammatory cytokine.

J. Iovanna, D. Closa, Y. Motoo, 2007, World journal of gastroenterology.

Effect of Camostat Mesilate on the Expression of Pancreatitis-Associated Protein (PAP), p8, and Cytokines in Rat Spontaneous Chronic Pancreatitis

J. Iovanna, S. Su, N. Sawabu, 2001, Pancreas.

Cloning and expression of the mouse PIP49 (Pancreatitis Induced Protein 49) mRNA which encodes a new putative transmembrane protein activated in the pancreas with acute pancreatitis.

R. Tomasini, A. A. Samir, J. Dagorn, 2000, Molecular cell biology research communications : MCBRC.

Acute-phase response of the rat pancreas protects against further aggression with severe necrotizing pancreatitis.

J. Dagorn, J. Iovanna, V. Keim, 1998, Critical care medicine.

The pancreatitis-associated protein is induced by free radicals in AR4-2J cells and confers cell resistance to apoptosis.

J. Dagorn, J. Iovanna, N. Dusetti, 1998, Gastroenterology.

Characterization of a silencer regulatory element in the rat PAP I gene which confers tissue-specific expression and is promoter-dependent.

J. Dagorn, J. Iovanna, N. Dusetti, 1997, Archives of biochemistry and biophysics.

Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down‐regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis

J. Dagorn, J. Iovanna, N. Dusetti, 1997, International journal of cancer.

Pancreatitis-Associated Protein Does Not Predict Disease Relapse in Inflammatory Bowel Disease Patients

M. Chamaillard, M. Sans, J. Dagorn, 2014, PloS one.

Experimental acute pancreatitis in PAP/HIP knock-out mice

S. Hunt, L. Christa, J. Dagorn, 2007, Gut.

Pancreatitis-Associated Protein I Suppresses NF-κB Activation through a JAK/STAT-Mediated Mechanism in Epithelial Cells1

Daniel Closa, J. Dagorn, J. Iovanna, 2006, The Journal of Immunology.

Overexpression of Pancreatitis-Associated Protein (PAP) in Human Pancreatic Ductal Adenocarcinoma

J. Iovanna, S. Su, K. Ohtsubo, 2003, Digestive Diseases and Sciences.

Temporary Pseudochronic Lesions During the Recovery of Acute Necrohemorrhagic Pancreatitis in Rabbits

J. Iovanna, Z. Berger, C. Odaira, 1988, Pancreas.

Localized necrohemorrhagic pancreatitis in the rat after pancreatic interstitial trypsin injection. Regressive pseudochronic lesions.

J. Iovanna, H. Sarles, Z. Berger, 1986, Digestion.

The Down-Expression of Tumor Protein 53-induced Nuclear Protein 1 (TP53INP1) in Human Gastric Cancer

J. Iovanna, S. Garcia, N. Sawabu, 2008 .

Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization.

M. Mattei, R. Tomasini, J. Dagorn, 2002, Cytogenetic and genome research.

Molecular and Functional Characterization of the Stress-induced Protein (SIP) Gene and Its Two Transcripts Generated by Alternative Splicing

R. Tomasini, A. A. Samir, J. Dagorn, 2001, The Journal of Biological Chemistry.

Targeting heat shock response pathways to treat pancreatic cancer.

J. Iovanna, Ling Peng, P. Rocchi, 2012, Drug discovery today.

A Review of Kinases Implicated in Pancreatic Cancer

J. Dagorn, J. Iovanna, V. Giroux, 2010, Pancreatology.

Inactivation of tryptic activity by a human-derived strain of Bacteroides distasonis in the large intestines of gnotobiotic rats and mice

J. Iovanna, I. Hautefort, P. Raibaud, 1996, Applied and environmental microbiology.

Targeting Fibrosis: The Bridge That Connects Pancreatitis and Pancreatic Cancer

J. Iovanna, P. Santofimia-Castaño, Can Huang, 2021, International journal of molecular sciences.

Induction of Apoptosis in Human Pancreatic Cancer Stem Cells by the Endoplasmic Reticulum-Targeted Alkylphospholipid Analog Edelfosine and Potentiation by Autophagy Inhibition

J. Iovanna, N. Dusetti, F. Mollinedo, 2021, Cancers.

Culture media composition influences patient-derived organoid ability to predict therapeutic responses in gastrointestinal cancers

Hu Li, M. Toruner, A. Oberg, 2022, JCI insight.

Stroma-targeting strategies in pancreatic cancer: a double-edged sword

J. Iovanna, P. Santofimia-Castaño, Xi Liu, 2022, Journal of Physiology and Biochemistry.

Cdx1 promotes differentiation in a rat intestinal epithelial cell line.

J. Dagorn, J. Iovanna, G. Mallo, 1999, Gastroenterology.

High level of tumour protein p53‐induced nuclear protein 1 (TP53INP1) expression in anaplastic carcinoma of the thyroid

A. Miyauchi, Yasuhiro Ito, J. Iovanna, 2006, Pathology.

Decreased expression of tumor protein p53-induced nuclear protein 1 (TP53INP1) in breast carcinoma.

A. Miyauchi, Yasuhiro Ito, Y. Takamura, 2006, Anticancer research.

Microwave promoted C–O coupling for synthesizing O-aryloxytriazole nucleoside analogues

J. Iovanna, G. Quéléver, Ling Peng, 2015 .

Current Knowledge on Pancreatic Cancer

J. Dagorn, J. Iovanna, A. Gonçalves, 2012, Front. Oncol..

Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF.

R. Rabadán, M. Barbacid, M. Hidalgo, 2019, Cancer cell.

Zymophagy, a Novel Selective Autophagy Pathway Mediated by VMP1-USP9x-p62, Prevents Pancreatic Cell Death*♦

J. Iovanna, R. Urrutia, M. Vaccaro, 2010, The Journal of Biological Chemistry.

Ligand-mediated highly effective and selective C-N coupling for synthesizing bioactive N-aryltriazole acyclonucleosides.

J. Iovanna, Ling Peng, P. Rocchi, 2010, Organic letters.

MicroRNAs in Pancreatic Ductal Adenocarcinoma: New Diagnostic and Therapeutic Clues

J. Dagorn, J. Iovanna, N. Dusetti, 2008, Pancreatology.

Further Characterization of HDAC and SIRT Gene Expression Patterns in Pancreatic Cancer and Their Relation to Disease Outcome

J. Iovanna, D. Lombardo, B. Sastre, 2014, PloS one.

Ribonuclease MCPiP1 contributes to the loss of micro-RNA-200 family members in pancreatic cancer cells

J. Iovanna, D. Lombardo, P. Soubeyran, 2018, Oncotarget.

Upcoming Revolutionary Paths in Preclinical Modeling of Pancreatic Adenocarcinoma

Mirna Swayden, Philippe Soubeyran, Juan Iovanna, 2020, Frontiers in Oncology.

Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe

Asha Nair, Asha A. Nair, Gwen Lomberk, 2017, Molecular Cancer Research.

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions.

I. Jurisica, T. Mak, G. Melino, 2008, Genes & development.

A subgroup of pancreatic adenocarcinoma is sensitive to the 5-aza-dC DNA methyltransferase inhibitor

J. Iovanna, N. Dusetti, P. Viens, 2014, Oncotarget.

E2F signature is predictive for the pancreatic adenocarcinoma clinical outcome and sensitivity to E2F inhibitors, but not for the response to cytotoxic-based treatments

J. Iovanna, N. Dusetti, P. Santofimia-Castaño, 2018, Scientific Reports.

The promise of epigenomic therapeutics in pancreatic cancer

J. Iovanna, G. Lomberk, R. Urrutia, 2016, Epigenomics.

Homeobox gene Cdx1 regulates Ras, Rho and PI3 kinase pathways leading to transformation and tumorigenesis of intestinal epithelial cells

Ivan Dikic, Juan Iovanna, J. Iovanna, 2001, Oncogene.

Cloning and expression of the mRNA of human galectin-4, an S-type lectin down-regulated in colorectal cancer.

J. Dagorn, J. Iovanna, G. Montalto, 1997, European journal of biochemistry.

Genome profiling of pancreatic adenocarcinoma

D. Birnbaum, P. Finetti, J. Iovanna, 2011, Genes, chromosomes & cancer.

Identification of multi-SH 3 domain-containing protein interactome in pancreatic cancer : A yeast

P. Lécine, J. Iovanna, N. Dusetti, 2008 .

Strengthened glycolysis under hypoxia supports tumor symbiosis and hexosamine biosynthesis in pancreatic adenocarcinoma

R. Tomasini, J. Iovanna, N. Dusetti, 2013, Proceedings of the National Academy of Sciences.

Epithelial IL-23R Signaling Licenses Protective IL-22 Responses in Intestinal Inflammation.

B. Becher, A. Kaser, P. Rosenstiel, 2016, Cell reports.

Metabolomic profiling of pancreatic adenocarcinoma reveals key features driving clinical outcome and drug resistance

J. Iovanna, N. Dusetti, R. Urrutia, 2021, EBioMedicine.

Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes.

N. Buttar, J. Iovanna, T. White, 2015, Endocrinology.

Pancreatic Cancer‐Induced Cachexia Is Jak2‐Dependent in Mice

J. Iovanna, V. Moutardier, O. Turrini, 2014, Journal of cellular physiology.

Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer

G. Kroemer, J. Iovanna, C. Cano, 2012, EMBO molecular medicine.

Krüppel-like Factor 11 Regulates the Expression of Metabolic Genes via an Evolutionarily Conserved Protein Interaction Domain Functionally Disrupted in Maturity Onset Diabetes of the Young

L. Miller, J. Iovanna, G. Lomberk, 2012, The Journal of Biological Chemistry.

DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses

David S. Park, T. Mak, J. Iovanna, 2009, Proceedings of the National Academy of Sciences.

DNA Methylation of PI3K/AKT Pathway-Related Genes Predicts Outcome in Patients with Pancreatic Cancer: A Comprehensive Bioinformatics-Based Study

J. Iovanna, W. Link, A. Gure, 2021, Cancers.

Redifferentiation and apoptosis of pancreatic cells during acute pancreatitis

J. Iovanna, 1996, International journal of pancreatology : official journal of the International Association of Pancreatology.

PML hyposumoylation is responsible for the resistance of pancreatic cancer

A. Carrier, J. Iovanna, N. Dusetti, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage

J. Iovanna, T. D. de Assunção, G. Lomberk, 2015, BMC Developmental Biology.

Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts

J. Iovanna, N. Dusetti, R. Urrutia, 2017, Cell reports.

PAP/REG3A favors perineural invasion in pancreatic adenocarcinoma and serves as a prognostic marker

R. Tomasini, J. Iovanna, E. Folch-Puy, 2017, Cellular and Molecular Life Sciences.

A Mycobacterium tuberculosis Dormancy Antigen Differentiates Latently Infected Bacillus Calmette–Guérin-vaccinated Individuals

J. Iovanna, V. García, D. Palmero, 2015, EBioMedicine.

Krüppel-like Factor 11 Differentially Couples to Histone Acetyltransferase and Histone Methyltransferase Chromatin Remodeling Pathways to Transcriptionally Regulate Dopamine D2 Receptor in Neuronal Cells

S. Brimijoin, A. Windebank, N. Buttar, 2012, The Journal of Biological Chemistry.

Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness.

S. Granjeaud, C. Brun, A. Sergé, 2016, The Journal of clinical investigation.

Pancreatic Cancer Heterogeneity Can Be Explained Beyond the Genome

J. Iovanna, N. Dusetti, N. Juiz, 2019, Front. Oncol..

Cancer of Exocrine Pancreas

A. Russo, J. Iovanna, M. Peeters, 2021, Practical Medical Oncology Textbook.

Inactivation of TIF1γ Cooperates with KrasG12D to Induce Cystic Tumors of the Pancreas

Kai-ping Yan, R. Losson, P. Dubus, 2009, PLoS genetics.

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

M. V. Vander Heiden, R. Tomasini, J. Iovanna, 2017, Nature Communications.

Gene expression profiling by DNA microarray analysis in mouse embryonic fibroblasts transformed by rasV12 mutated protein and the E1A oncogene

J. Dagorn, J. Iovanna, C. Labrie, 2003, Molecular Cancer.

Regulation of apoptosis by the p8/prothymosin α complex

J. Dagorn, J. Iovanna, J. Neira, 2006 .

Stress Proteins and Pancreatic Cancer Metastasis

J. Iovanna, C. Cano, 2010, TheScientificWorldJournal.

Expression of the stress-associated protein p8 is a requisite for tumor development

J. Iovanna, 2002, International journal of gastrointestinal cancer.

GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer

N. Malats, F. Real, M. Büchler, 2016, Gut.

Cloning and expression of the human p8, a nuclear protein with mitogenic activity.

J. Iovanna, E. Cánepa, G. Mallo, 2001, European journal of biochemistry.

Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis.

M. Fabbri, J. Iovanna, N. Dusetti, 2013, Cancer letters.

J. Iovanna, M. Vila-Casadesús, J. Lozano, 2020, Oncogenesis.

Loss of Tribbles pseudokinase-3 promotes Akt-driven tumorigenesis via FOXO inactivation

J. Flores, A. Carracedo, J. Iovanna, 2014, Cell Death and Differentiation.

ArgBP2-dependent signaling regulates pancreatic cell migration, adhesion, and tumorigenicity.

J. Iovanna, F. André, P. Soubeyran, 2008, Cancer research.

IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation.

R. Tomasini, J. Iovanna, G. Lomberk, 2014, The Journal of clinical investigation.

Lipopolysaccharide directly affects pancreatic acinar cells: implications on acute pancreatitis pathophysiology.

J. Iovanna, E. Calvo, M. Vaccaro, 2000, Digestive diseases and sciences.

Melatonin induces reactive oxygen species generation and changes in glutathione levels and reduces viability in human pancreatic stellate cells

J. Iovanna, M. Estaras, V. Roncero, 2019, Journal of Physiology and Biochemistry.

Stratification of Pancreatic Ductal Adenocarcinomas Based on Tumor and Microenvironment Features.

D. Franchimont, P. Laurent-Puig, J. Devière, 2018, Gastroenterology.

Inactivation of the Euchromatic Histone-Lysine N-Methyltransferase 2 Pathway in Pancreatic Epithelial Cells Antagonizes Cancer Initiation and Pancreatitis-Associated Promotion by Altering Growth and Immune Gene Expression Networks

Michael T. Zimmermann, M. Zimmermann, J. Iovanna, 2021, Frontiers in Cell and Developmental Biology.

Protein kinase CK2α subunit over-expression correlates with metastatic risk in breast carcinomas: quantitative immunohistochemistry in tissue microarrays.

D. Birnbaum, J. Iovanna, P. Bonnier, 2011, European journal of cancer.

Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.

R. Schmid, J. Dagorn, J. Iovanna, 2012, The Journal of clinical investigation.

VAV2 regulates epidermal growth factor receptor endocytosis and degradation

J. Iovanna, N. Dusetti, P. Soubeyran, 2010, Oncogene.

Hypoxia Induced Tumor Metabolic Switch Contributes to Pancreatic Cancer Aggressiveness

R. Tomasini, J. Iovanna, S. Vasseur, 2010, Cancers.

TNF-α induces endothelial–mesenchymal transition promoting stromal development of pancreatic adenocarcinoma

J. Iovanna, B. Binétruy, S. Audebert, 2021, Cell Death & Disease.

Arginine-terminated generation 4 PAMAM dendrimer as an effective nanovector for functional siRNA delivery in vitro and in vivo.

C. Liu, J. Iovanna, Ling Peng, 2014, Bioconjugate chemistry.

Pancreatic Ductal Adenocarcinoma: A Strong Imbalance of Good and Bad Immunological Cops in the Tumor Microenvironment

Jérôme Galon, Daniel Olive, Juan Iovanna, 2018, Front. Immunol..

First International Cisapride Investigators’ Meeting

W. Schwerk, K. Ohlsson, J. Iovanna, 1986 .

Lipopolysaccharide Directly Affects Pancreatic Acinar Cells

J. Iovanna, E. Calvo, M. Vaccaro, 2000, Digestive Diseases and Sciences.

Acute Pancreatitis Is Not a Cause of Chronic Pancreatitis in the Absence of Residual Duct Strictures

J. Iovanna, H. Sarles, R. Choux, 1993, Pancreas.

Newly synthesized amylase, lipase and serine proteases are transported at different rates in rat pancreas.

J. Dagorn, J. Iovanna, D. Giorgi, 1986, Digestion.

Amylase and Chymotrypsinogen Synthesis and Secretion by the Anesthetized Rat Pancreas

J. Dagorn, J. Iovanna, D. Giorgi, 1987, Pancreas.

Regulation of concentrations of mRNA for amylase, trypsinogen I and chymotrypsinogen B in rat pancreas by secretagogues.

J. Dagorn, J. Iovanna, D. Giorgi, 1986, The Biochemical journal.

Tumor Biology and Natural History

A. Russo, V. Bazan, J. Iovanna, 2021, Practical Medical Oncology Textbook.

Cancer Clonal Evolution and Intra-tumor Heterogeneity

A. Giordano, A. Russo, J. Iovanna, 2017 .

KrasG12D induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells

Michael T. Zimmermann, M. Zimmermann, J. Iovanna, 2021, Genome biology.

Expression profiling in pancreas during the acute phase of pancreatitis using cDNA microarrays.

R. Tomasini, J. Dagorn, J. Iovanna, 2000, Biochemical and biophysical research communications.

Inhibition of Transforming Growth Factor &bgr; Signaling by Halofuginone as a Modality for Pancreas Fibrosis Prevention

O. Halevy, A. Nagler, M. Pines, 2009, Pancreas.

Effect of Carboxamide Derivative IS-741 on Rat Spontaneous Chronic Pancreatitis

J. Iovanna, S. Su, N. Sawabu, 2004, Digestive Diseases and Sciences.

The Stress Response of the Exocrine Pancreas

J. Iovanna, H. Bödeker, S. Gaiser, 2005, Digestive Diseases.

Quantitation of autophagy in the pancreas at the tissue and cell levels

J. Iovanna, 2010 .

Rs488087 single nucleotide polymorphism as predictive risk factor for pancreatic cancers

D. Figarella-Branger, J. Iovanna, F. Barlesi, 2015, Oncotarget.

Localization of rat pancreatitis-associated protein during bile salt-induced pancreatitis.

J. Iovanna, G. Grondin, J. Morisset, 1997, Gastroenterology.

The acute phase reaction of the exocrine pancreas. Gene expression and synthesis of pancreatitis-associated proteins.

J. Dagorn, J. Iovanna, V. Keim, 1994, Digestion.

Expression of Vacuole Membrane Protein 1 (VMP1) in Spontaneous Chronic Pancreatitis in the WBN/Kob Rat

J. Iovanna, M. Vaccaro, N. Sawabu, 2004, Pancreas.

p8 Expression Is Induced in Acinar Cells During Chronic Pancreatitis

J. Iovanna, S. Su, G. Mallo, 2001, Digestive Diseases and Sciences.

Pancreatic acinar cells submitted to stress activate TNF-alpha gene expression.

J. Iovanna, E. Calvo, M. Vaccaro, 2000, Biochemical and biophysical research communications.

Effects of intravenous ethanol on basal bile-pancreatic secretion in nonalcoholic and alcohol-fed rats.

J. Iovanna, O. Tumilasci, D. Dreiling, 1990, The Mount Sinai journal of medicine, New York.

Changes in Gene Expression During Pancreatic Regeneration: Activation of c‐myc and H‐ras Oncogenes in the Rat Pancreas

J. Dagorn, J. Iovanna, N. Dusetti, 1991, Pancreas.

Differential Expression of Pancreatitis-Associated Protein and Thrombospondins in Arterial versus Venous Tissues

J. Paulauskis, J. Iovanna, S. Watts, 2009, Journal of Vascular Research.

Cadherin-1 and cadherin-3 cooperation determines the aggressiveness of pancreatic ductal adenocarcinoma

Anna R Martirosyan, R. Tomasini, J. Iovanna, 2017, British Journal of Cancer.

The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes KrasG12D-mediated pancreatic cancer initiation

J. Iovanna, N. Dusetti, G. Lomberk, 2016, Cell Death and Disease.

[Autophagy contributes to the initiation of pancreatic cancer].

J. Iovanna, 2017, Medecine sciences : M/S.

Can the plasma PD-1 levels predict the presence and efficiency of tumor-infiltrating lymphocytes in patients with metastatic melanoma?

D. Olive, A. Russo, F. Fulfaro, 2019, Therapeutic advances in medical oncology.

Early molecular and functional changes in colonic epithelium that precede increased gut permeability during colitis development in mdr1a(−/−) mice

L. Zeef, J. Iovanna, A. Collett, 2008, Inflammatory bowel diseases.

Masitinib Combined with Standard Gemcitabine Chemotherapy: In Vitro and In Vivo Studies in Human Pancreatic Tumour Cell Lines and Ectopic Mouse Model

F. Bertucci, P. Finetti, J. Iovanna, 2010, PloS one.

GLI1, a novel target of the ER stress regulator p97/VCP, promotes ATF6f-mediated activation of XBP1.

M. Toruner, J. Iovanna, R. Vera, 2023, Biochimica et biophysica acta. Gene regulatory mechanisms.

Combating pancreatic cancer chemoresistance by triggering multiple cell death pathways.

J. Iovanna, P. Santofimia-Castaño, 2021, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

Implementing biological markers as a tool to guide clinical care of patients with pancreatic cancer

J. Iovanna, 2020, Translational oncology.

A transcriptomic signature to predict adjuvant gemcitabine sensitivity in pancreatic adenocarcinoma.

A. Reyniès, J. Iovanna, N. Dusetti, 2020, Annals of oncology : official journal of the European Society for Medical Oncology.

Pancreatic cancer chemo-resistance is driven by tumor phenotype rather than tumor genotype

J. Iovanna, M. Swayden, P. Soubeyran, 2018, Heliyon.

LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker.

S. Granjeaud, R. Tomasini, J. Iovanna, 2018, Cancer research.

Differential Therapy Based on Tumor Heterogeneity in Pancreatic Cancer

J. Iovanna, N. Dusetti, M. Bigonnet, 2017 .

A pancreatic ductal adenocarcinoma subpopulation is sensitive to FK866, an inhibitor of NAMPT

J. Iovanna, N. Dusetti, S. Garcia, 2016, Oncotarget.

Heterogeneity of metastatic pancreatic adenocarcinoma: Lung metastasis show better prognosis than liver metastasis-a case control study.

J. Iovanna, P. Viens, J. Raoul, 2016, Oncotarget.

Targeting CD44 as a novel therapeutic approach for treating pancreatic cancer recurrence

J. Iovanna, N. Dusetti, J. Delpero, 2015, Oncoscience.

Transcriptomic analysis predicts survival and sensitivity to anticancer drugs of patients with a pancreatic adenocarcinoma.

J. Iovanna, N. Dusetti, P. Viens, 2015, The American journal of pathology.

OGX-427 inhibits tumor progression and enhances gemcitabine chemotherapy in pancreatic cancer

M. Gleave, J. Iovanna, C. Garrido, 2011, Cell Death and Disease.

Dendrimers as competitors of protein-protein interactions of the intrinsically disordered nuclear chromatin protein NUPR1.

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2019, Biomacromolecules.

Gemcitabine Induces the VMP1-Mediated Autophagy Pathway to Promote Apoptotic Death in Human Pancreatic Cancer Cells

J. Iovanna, D. Papademetrio, M. Vaccaro, 2010, Pancreatology.

A glycosyltransferase gene signature to detect pancreatic ductal adenocarcinoma patients with poor prognosis

J. Iovanna, N. Dusetti, J. Cros, 2021, EBioMedicine.

Tumor protein 53-induced nuclear protein 1 expression is repressed by miR-155, and its restoration inhibits pancreatic tumor development

Ladan Fazli, Kuan-Teh Jeang, Richard Tomasini, 2007, Proceedings of the National Academy of Sciences.

Intrinsically disordered protein NUPR1 binds to the armadillo-repeat domain of Plakophilin 1.

J. Iovanna, J. Neira, P. Santofimia-Castaño, 2020, International journal of biological macromolecules.

Disruption of a Novel Krüppel-like Transcription Factor p300-regulated Pathway for Insulin Biosynthesis Revealed by Studies of the c.-331 INS Mutation Found in Neonatal Diabetes Mellitus*

U. Hodoğlugil, R. Scharfmann, P. Froguel, 2011, The Journal of Biological Chemistry.

Autophagy Induced during Pancreatitis Promotes KRAS-Dependent Transformation in the Pancreas

J. Iovanna, 2016, Front. Oncol..

Autophagy in Pancreatic Cancer

J. Iovanna, D. Grasso, M. N. García, 2012, International journal of cell biology.

Cloning of IP15, a pancreatitis-induced gene whose expression inhibits cell growth.

R. Tomasini, J. Iovanna, N. Dusetti, 2004, Biochemical and biophysical research communications.

Limitation and challenges in using pancreatic cancer‐derived organoids as a preclinical tool

J. Iovanna, N. Dusetti, N. Fraunhoffer, 2022, Cancer communications.

Mice with targeted disruption of p8 gene show increased sensitivity to lipopolysaccharide and DNA microarray analysis of livers reveals an aberrant gene expression response

J. Dagorn, J. Iovanna, D. Closa, 2003, BMC gastroenterology.

PAP gene transcription induced by cycloheximide in AR4-2J cells involves ADP-ribosylation.

J. Dagorn, J. Iovanna, N. Dusetti, 1998, Biochemical and biophysical research communications.

NUPR1: A Critical Regulator of the Antioxidant System

J. Iovanna, P. Santofimia-Castaño, Can Huang, 2021, Cancers.

Human Endogenous Retrovirus (HERV)-K env Gene Knockout Affects Tumorigenic Characteristics of nupr1 Gene in DLD-1 Colorectal Cancer Cells

Yung-Hyun Choi, Kyudong Han, J. Iovanna, 2021, International journal of molecular sciences.

NUPR1 interacts with eIF2α and is required for resolution of the ER stress response in pancreatic tissue

J. Iovanna, P. Santofimia-Castaño, P. Soubeyran, 2021, The FEBS journal.

The stress-induced protein NUPR1 orchestrates protein translation during ER-stress by interacting with eIF2α

J. Iovanna, P. Santofimia-Castaño, P. Soubeyran, 2020, bioRxiv.

NUPR1, a new target in liver cancer: implication in controlling cell growth, migration, invasion and sorafenib resistance

J. McCubrey, D. Bachvarov, M. Libra, 2016, Cell Death and Disease.

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis

A. Carrier, J. Iovanna, J. Neira, 2018, Scientific Reports.

Deciphering the Binding between Nupr1 and MSL1 and Their DNA-Repairing Activity

A. Velázquez‐Campoy, D. Pantoja-Uceda, J. Iovanna, 2013, PloS one.

p8-deficient fibroblasts grow more rapidly and are more resistant to adriamycin-induced apoptosis

R. Feil, J. Dagorn, J. Iovanna, 2002, Oncogene.

TAp73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses

T. Mak, G. Melino, M. Wilhelm, 2012, Cell Death and Differentiation.

Serum from rats with acute pancreatitis induces expression of the PAP mRNA in the pancreatic acinar cell line AR-42J.

J. Dagorn, J. Iovanna, N. Dusetti, 1994, Biochemical and biophysical research communications.

Tie1 deficiency induces endothelial–mesenchymal transition

J. Pouysségur, J. Iovanna, M. Sandí, 2012, EMBO reports.

The homeobox gene Cdx1 belongs to the p53-p21(WAF)-Bcl-2 network in intestinal epithelial cells.

J. Dagorn, J. Iovanna, P. Soubeyran, 2002, Biochemical and biophysical research communications.

Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis.

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2019, The Journal of clinical investigation.

The thymus-specific serine protease TSSP/PRSS16 is crucial for the antitumoral role of CD4(+) T cells.

A. Carrier, J. Iovanna, S. Garcia, 2015, Cell reports.

TP53INP1 is a novel p73 target gene that induces cell cycle arrest and cell death by modulating p73 transcriptional activity

R. Tomasini, A. Carrier, J. Dagorn, 2005, Oncogene.

Identification of new mechanisms of cellular response to chemotherapy by tracking changes in post-translational modifications by ubiquitin and ubiquitin-like proteins.

Jean-Paul Borg, Maxime Garcia, Thomas Bonacci, 2014, Journal of proteome research.

A “Lymphocyte MicroRNA Signature” as Predictive Biomarker of Immunotherapy Response and Plasma PD-1/PD-L1 Expression Levels in Patients with Metastatic Renal Cell Carcinoma: Pointing towards Epigenetic Reprogramming

A. Russo, V. Bazan, J. Iovanna, 2020, Cancers.

Long‐term survivors after pancreatectomy for cancer: the TNM classification is outdated

J. Iovanna, J. Delpero, J. Ewald, 2015, ANZ journal of surgery.

Metabolomic profiling of pancreatic adenocarcinoma reveals fundamental clinical features

J. Iovanna, N. Dusetti, R. Urrutia, 2021, bioRxiv.

TP53INP1 overexpression in prostate cancer correlates with poor prognostic factors and is predictive of biological cancer relapse

M. Gleave, J. Iovanna, N. Dusetti, 2012, The Prostate.

Mechanistic insights into self-reinforcing processes driving abnormal histogenesis during the development of pancreatic cancer.

J. Iovanna, R. Urrutia, D. Marks, 2013, The American journal of pathology.

J. Dagorn, J. Iovanna, G. Dressler, 2002, The Journal of Biological Chemistry.

Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine

J. Iovanna, N. Dusetti, R. Urrutia, 2019, Nature Communications.

Prognostic Role of Plasma PD-1, PD-L1, pan-BTN3As and BTN3A1 in Patients Affected by Metastatic Gastrointestinal Stromal Tumors: Can Immune Checkpoints Act as a Sentinel for Short-Term Survival?

A. Russo, V. Bazan, J. Iovanna, 2021, Cancers.

Role of tumor-infiltrating lymphocytes in patients with solid tumors: Can a drop dig a stone?

A. Russo, V. Bazan, V. Caló, 2018, Cellular immunology.

Aurora kinase B-phosphorylated HP1α functions in chromosomal instability

Michael T. Zimmermann, M. Zimmermann, J. Iovanna, 2019, Cell cycle.

Baseline plasma levels of soluble PD-1, PD-L1, and BTN3A1 predict response to nivolumab treatment in patients with metastatic renal cell carcinoma: a step toward a biomarker for therapeutic decisions

C. Porta, D. Olive, A. Russo, 2020, Oncoimmunology.

Prognostic significance of circulating PD-1, PD-L1, pan-BTN3As, BTN3A1 and BTLA in patients with pancreatic adenocarcinoma

D. Olive, A. Russo, J. Iovanna, 2019, Oncoimmunology.

BTN3A is a prognosis marker and a promising target for Vγ9Vδ2 T cells based-immunotherapy in pancreatic ductal adenocarcinoma (PDAC)

D. Olive, J. Dagorn, J. Iovanna, 2018, Oncoimmunology.

NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells

S. Goruppi, A. Carracedo, J. Dagorn, 2013, Autophagy.

Nidogen 1 and Nuclear Protein 1: novel targets of ETV5 transcription factor involved in endometrial cancer invasion

X. Matías-Guiu, J. Iovanna, F. Alameda, 2015, Clinical & Experimental Metastasis.

Pancreatic Cancer Organoids for Determining Sensitivity to Bromodomain and Extra-Terminal Inhibitors (BETi)

J. Iovanna, N. Dusetti, J. Cros, 2019, Front. Oncol..

Loss of the Protein NUPR1 (p8) Leads to Delayed LHB Expression, Delayed Ovarian Maturation, and Testicular Development of a Sertoli-Cell-Only Syndrome-Like Phenotype in Mice1

J. Iovanna, M. King, C. M. Million Passe, 2008, Biology of reproduction.

Human importin α3 and its N-terminal truncated form, without the importin-β-binding domain, are oligomeric species with a low conformational stability in solution.

M. Prieto, A. Cámara-Artigas, J. Iovanna, 2020, Biochimica et biophysica acta. General subjects.

The reg4 Gene, Amplified in the Early Stages of Pancreatic Cancer Development, Is a Promising Therapeutic Target

J. Dagorn, J. Iovanna, C. Cano, 2009, PloS one.

An efficient mixed-ligand Pd catalytic system to promote C-N coupling for the synthesis of N-arylaminotriazole nucleosides.

J. Iovanna, Ling Peng, P. Rocchi, 2012, Chemistry.

Intrinsically disordered chromatin protein NUPR1 binds to the enzyme PADI4.

J. Iovanna, J. Neira, P. Santofimia-Castaño, 2023, Journal of molecular biology.

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis

A. Carrier, J. Iovanna, J. Neira, 2018, bioRxiv.

Defects in mitophagy promote redox-driven metabolic syndrome in the absence of TP53INP1

M. Ravier, G. Rutter, P. Marchetti, 2015, EMBO molecular medicine.

Urinary levels of Hepatocarcinoma-intestine-pancreas/Pancreatitis-associated protein as a diagnostic biomarker in patients with bladder cancer

Tomoaki Tanaka, J. Iovanna, H. Kiyama, 2012, BMC Urology.

Targeting intrinsically disordered proteins involved in cancer

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2019, Cellular and Molecular Life Sciences.

The Paralogue of the Intrinsically Disordered Nuclear Protein 1 Has a Nuclear Localization Sequence that Binds to Human Importin α3

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2020, International journal of molecular sciences.

A Phosphorylation-Induced Switch in the Nuclear Localization Sequence of the Intrinsically Disordered NUPR1 Hampers Binding to Importin

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2020, Biomolecules.

Epithelial-to-Mesenchymal Transition in Pancreatic Adenocarcinoma

J. Iovanna, C. Cano, Y. Motoo, 2010, TheScientificWorldJournal.

Targeting heat shock factor 1 with a triazole nucleoside analog to elicit potent anticancer activity on drug-resistant pancreatic cancer.

J. Iovanna, Ling Peng, P. Rocchi, 2012, Cancer letters.

The TP53INP2 protein is required for autophagy in mammalian cells.

J. Dagorn, J. Iovanna, M. Pébusque, 2008, Molecular biology of the cell.

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes

Gavin R. Oliver, J. Iovanna, N. Dusetti, 2018, Nature Communications.

Overexpression of p8 is inversely correlated with apoptosis in pancreatic cancer.

J. Iovanna, S. Su, K. Ohtsubo, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Inhibition of glucuronidation in pancreatic cancer improves gemcitabine anticancer activity

J. Iovanna, N. Dusetti, O. Gayet, 2022, Cancer communications.

A Molecular Gradient as a universal classifier of pancreatic adenocarcinoma that predicts tumor aggressiveness and mFOLFIRINOX sensitivity.

A. Reyniès, J. Iovanna, N. Dusetti, 2020 .

Molecular and Functional Characterization of the Stress-induced Protein (SIP) Gene and Its Two Transcripts Generated by Alternative Splicing SIP INDUCED BY STRESS AND PROMOTES CELL DEATH*

R. Tomasini, A. A. Samir, J. Dagorn, 2001 .

Stress-inducible Protein p8 Is Involved in Several Physiological and Pathological Processes*

S. Goruppi, J. Iovanna, 2009, The Journal of Biological Chemistry.

Cell growth‐dependent subcellular localization of p8

J. Iovanna, E. Cánepa, C. Varone, 2006, Journal of cellular biochemistry.

Inactivation of stress protein p8 increases murine carbon tetrachloride hepatotoxicity via preserved CYP2E1 activity

J. Dagorn, J. Iovanna, D. Taïeb, 2005, Hepatology.

Human p8 Is a HMG-I/Y-like Protein with DNA Binding Activity Enhanced by Phosphorylation*

J. González-Ros, J. Encinar, L. Giono, 2001, The Journal of Biological Chemistry.

pap, reg Ialpha and reg Ibeta mRNAs are concomitantly up-regulated during human colorectal carcinogenesis.

J. Dagorn, J. Iovanna, G. Mallo, 1999, International journal of cancer.

Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1).

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2018, Biochimica et biophysica acta. General subjects.

Detailed Structural-Functional Analysis of the Krüppel-like Factor 16 (KLF16) Transcription Factor Reveals Novel Mechanisms for Silencing Sp/KLF Sites Involved in Metabolism and Endocrinology

N. Buttar, J. Iovanna, G. Lomberk, 2011, The Journal of Biological Chemistry.

New strategies and designs in pancreatic cancer research: consensus guidelines report from a European expert panel.

D. Aust, T. Conroy, J. Neoptolemos, 2012, Annals of oncology : official journal of the European Society for Medical Oncology.

Spatially-resolved metabolomic identifies colibactin-specific principles of reprogrammed lipid metabolism to promote cancer progression

I. Sobhani, M. Chamaillard, P. Sansonetti, 2023, bioRxiv.

Impact of Different Selection Approaches for Identifying Lynch Syndrome-Related Colorectal Cancer Patients: Unity Is Strength

A. Russo, V. Bazan, V. Caló, 2022, Frontiers in Oncology.

Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B

M. Vidal, J. Iovanna, J. Neira, 2017, Proceedings of the National Academy of Sciences.

Interaction of the stress protein p8 with Jab1 is required for Jab1-dependent p27 nuclear-to-cytoplasm translocation.

J. Dagorn, J. Iovanna, D. Closa, 2006, Biochemical and biophysical research communications.

BBRC Interaction of the stress protein p 8 with Jab 1 is required for Jab 1-dependent p 27 nuclear-to-cytoplasm translocation

J. Dagorn, J. Iovanna, D. Closa, 2005 .

Transforming growth factor beta-1 enhances Smad transcriptional activity through activation of p8 gene expression.

L. Giono, J. Dagorn, J. Iovanna, 2001, The Biochemical journal.

Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promoter.

J. Iovanna, E. Cánepa, G. Mallo, 1999, The Biochemical journal.

TP53INP2 is the new guest at the table of self-eating

J. Iovanna, J. Nowak, 2009, Autophagy.

Crowding Effects on the Structure and Dynamics of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1

J. Iovanna, J. Neira, R. Pierattelli, 2021, Frontiers in Molecular Biosciences.

TP53INP1 as new therapeutic target in castration‐resistant prostate cancer

M. Gleave, L. Fazli, J. Iovanna, 2012, The Prostate.

Identification of multi‐SH3 domain‐containing protein interactome in pancreatic cancer: A yeast two‐hybrid approach

Aurélie Hermant, P. Lécine, Aurélie Hermant, 2008, Proteomics.

Contents Vol. 9, 2009

Bechien U. Wu, T. Tsai, B. Petersen, 2010, Pancreatology.

Combined inhibition of PAK7, MAP3K7 and CK2α kinases inhibits the growth of MiaPaCa2 pancreatic cancer cell xenografts

J. Dagorn, J. Iovanna, S. Garcia, 2009, Cancer Gene Therapy.

Probing the human kinome for kinases involved in pancreatic cancer cell survival and gemcitabine resistance

Juan Iovanna, J. Dagorn, J. Iovanna, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

CIN85 regulates the ability of MEKK4 to activate the p38 MAP kinase pathway.

J. Iovanna, Y. Aissouni, P. Soubeyran, 2005, Biochemical and biophysical research communications.

Expression of p8 protein in breast carcinoma; an inverse relationship with apoptosis.

A. Miyauchi, Yasuhiro Ito, Y. Takamura, 2005, Anticancer research.

Transforming growth factor β1 enhances Smad transcriptional activity through activation of p 8 gene expression

L. Giono, J. Dagorn, J. Iovanna, 2022 .

PAMAM Dendrimers Mediate siRNA Delivery to Target Hsp27 and Produce Potent Antiproliferative Effects on Prostate Cancer Cells

Ling Peng, Juan Iovanna, M. Gleave, 2009, ChemMedChem.

The WSB1 Gene Is Involved in Pancreatic Cancer Progression

J. Dagorn, J. Iovanna, S. Garcia, 2008, PloS one.

Identification of Genomic Alterations Associated with the Aggressiveness of Pancreatic Cancer Using an Ultra-High-Resolution CGH Array

J. Dagorn, J. Iovanna, M. Barthet, 2009, Pancreatology.

Novel combination of Celecoxib and proteasome inhibitor MG132 provides synergistic antiproliferative and proapoptotic effects in human liver tumor cells

J. McCubrey, D. Bachvarov, J. Iovanna, 2010, Cell cycle.

Validation of an immunohistochemical signature predictive of 8‐year outcome for patients with breast carcinoma

D. Birnbaum, J. Iovanna, P. Bonnier, 2012, International journal of cancer.

Immunohistochemical profiling of node negative breast carcinomas allows prediction of metastatic risk.

D. Birnbaum, J. Iovanna, P. Bonnier, 2010, International journal of oncology.

TRIB3 suppresses tumorigenesis by controlling mTORC2/AKT/FOXO signaling

J. Flores, A. Carracedo, J. Iovanna, 2015, Molecular & cellular oncology.

Nitric Oxide Supplementation Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice

M. Sans, J. Iovanna, J. Panés, 2002, Laboratory Investigation.

Soluble forms of PD-L1 and PD-1 as prognostic and predictive markers of sunitinib efficacy in patients with metastatic clear cell renal cell carcinoma

N. Rioux-Leclercq, G. Pagès, J. Iovanna, 2020, Oncoimmunology.

Nupr1 deficiency downregulates HtrA1, enhances SMAD1 signaling, and suppresses age‐related bone loss in male mice

M. Mawatari, J. Iovanna, T. Komori, 2023, Journal of cellular physiology.

Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function

O. Abián, A. Velázquez‐Campoy, J. Iovanna, 2021, Biomolecules.

Targeting NUPR1 with the small compound ZZW-115 is an efficient strategy to treat hepatocellular carcinoma.

J. Iovanna, P. Santofimia-Castaño, Ling Peng, 2020, Cancer letters.

Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating KrasG12D-induced senescence

J. Iovanna, C. Cano, G. Lomberk, 2014, Cell Death and Differentiation.

Pancreatitis promotes oncogenic KrasG12D-induced pancreatic transformation through activation of Nupr1

J. Iovanna, C. Cano, G. Lomberk, 2014, Molecular & cellular oncology.

Upregulation of the stress‐associated gene p8 in mouse models of demyelination and in multiple sclerosis tissues

M. Carson, J. Iovanna, S. Miller, 2006, Glia.

Overexpression of p 8 Is Inversely Correlated with Apoptosis in Pancreatic Cancer 1

J. Iovanna, S. Su, K. Ohtsubo, 2001 .

Cloning, expression and chromosomal localization of the rat pancreatitis-associated protein III gene.

J. Dagorn, J. Iovanna, N. Dusetti, 1995, The Biochemical journal.

Highlights of the 25th Conference of the European Society for Microcirculation

Blair D. Johnson, J. Paulauskis, M. Chiariello, 2009, Journal of Vascular Research.

FGFR3 has tumor suppressor properties in cells with epithelial phenotype

P. Dubus, S. Dabernat, F. Moreau-Gaudry, 2013, Molecular Cancer.

Triple negative breast carcinoma EGFR amplification is not associated with EGFR, Kras or ALK mutations

J. Iovanna, C. Charpin, L. Boubli, 2014, British Journal of Cancer.

Inducing ferroptosis by the NUPR1 inhibitor ZZW115 to kill pancreatic cancer cells

J. Iovanna, P. Santofimia-Castaño, N. Fraunhoffer, 2020 .

Time‐Dependent Effect of Melatonin on Actin mRNA Levels and Incorporation of 35S‐Methionine Into Actin and Proteins by the Rat Hypothalamus

D. Cardinali, J. Iovanna, N. Dusetti, 1990, Journal of pineal research.

CIP4 is a new ArgBP2 interacting protein that modulates the ArgBP2 mediated control of WAVE1 phosphorylation and cancer cell migration.

J. Iovanna, N. Dusetti, D. Taïeb, 2010, Cancer letters.

Adénocarcinome du pancréas : à quand un traitement personnalisé ? Adenocarcinoma of the Pancreas: When a Personalized Treatment?

J. Iovanna, 2015 .

A Novel Arylethynyltriazole Acyclonucleoside Inhibits Proliferation of Drug‐Resistant Pancreatic Cancer Cells.

J. Iovanna, Ling Peng, Menghua Wang, 2011 .

[Organoids from pancreatic ductal adenocarcinoma].

J. Iovanna, N. Dusetti, 2020, Medecine sciences : M/S.

Priming therapy by targeting enhancer-initiated pathways in patient-derived pancreatic cancer cells

É. Lebarbier, J. Iovanna, N. Dusetti, 2023, EBioMedicine.

Low plasma PD-L1 levels, early tumor onset and absence of peritoneal carcinomatosis improve prognosis of women with advanced high-grade serous ovarian cancer

A. Giordano, S. Vieni, V. Bazan, 2023, BMC Cancer.

Adaptation of redox metabolism in drug-tolerant persister cells is a vulnerability to prevent relapse in pancreatic cancer

A. Carrier, J. Iovanna, J. Sarry, 2024, bioRxiv.

Induction of lithostathine/reg mRNA expression by serum from rats with acute pancreatitis and cytokines in pancreatic acinar AR-42J cells.

J. Dagorn, J. Iovanna, N. Dusetti, 1996, Archives of biochemistry and biophysics.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Combining the antianginal drug perhexiline with chemotherapy induces complete pancreatic cancer regression in vivo

L. Linares, A. Carrier, J. Iovanna, 2023, iScience.

Nidogen 1 and Nuclear Protein 1: novel targets of ETV5 transcription factor involved in endometrial cancer invasion

Marta García, X. Matías-Guiu, J. Iovanna, 2015, Clinical & Experimental Metastasis.

Clusterin overexpression in rat pancreas during the acute phase of pancreatitis and pancreatic development.

J. Dagorn, J. Iovanna, E. Calvo, 1998, European Journal of Biochemistry.

REG3β modifies cell tumor function by impairing extracellular vesicle uptake

J. Iovanna, D. Closa, M. Gironella, 2017, Scientific Reports.

Cdx1 homeobox gene during human colon cancer progression

J. Iovanna, M. Gaub, E. Guérin, 2003, Oncogene.

p8 and Prothymosin Alpha : Unity is Strength

J. Dagorn, J. Iovanna, J. Neira, 2006, Cell cycle.

Regulation of apoptosis by the p 8 prothymosin complex

J. Dagorn, J. Iovanna, J. Neira, 2006 .

OncoSNIPE® Study Protocol, a study of molecular profiles associated with development of resistance in solid cancer patients

N. Girard, R. Boidot, J. Iovanna, 2022, BMC cancer.

Molecular and Cellular Pathobiology Reg 3 b De fi ciency Impairs Pancreatic Tumor Growth by Skewing Macrophage Polarization

J. Iovanna, J. Roselló-Catafau, E. Folch-Puy, 2013 .

Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene.

M. Fox, D. Swallow, J. Dagorn, 1994, Genomics.

Expression of HIP/PAP mRNA in Human Hepatoma Cell Lines

J. Iovanna, M. Notarbartolo, M. Cervello, 2002, Annals of the New York Academy of Sciences.

Gene expression profiling of tumours derived from rasV12/E1A-transformed mouse embryonic fibroblasts to identify genes required for tumour development

J. Dagorn, J. Iovanna, S. Vasseur, 2005, Molecular Cancer.

Resectable pancreatic head adenocarcinoma: Is R0 resection an illusion? Genetic evaluation of venous resection margin affirmed unrecognized disease.

J. Iovanna, J. Delpero, J. Ewald, 2017, Journal of visceral surgery.

Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression

J. Iovanna, P. Svingen, G. Lomberk, 2013, Epigenetics & Chromatin.

PAP/REG3A favors perineural invasion in pancreatic adenocarcinoma and serves as a prognostic marker

R. Tomasini, J. Iovanna, E. Folch-Puy, 2017, Cellular and Molecular Life Sciences.

Pancreatic tumor cell metabolism: focus on glycolysis and its connected metabolic pathways.

J. Iovanna, S. Vasseur, F. Guillaumond, 2014, Archives of biochemistry and biophysics.

Deciphering cadherin-1 and cadherin-3 roles in pancreatic ductal adenocarcinoma aggressiveness

Anna R Martirosyan, R. Tomasini, J. Iovanna, 2017 .

LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma

F. Bertucci, P. Finetti, R. Tomasini, 2021, Communications Biology.

Pancreatic ductal adenocarcinoma ubiquitination profiling reveals specific prognostic and theranostic markers

J. Iovanna, N. Dusetti, S. Audebert, 2023, EBioMedicine.

Involvement of Tubular Complexes in Pancreatic Regeneration After Acute Necrohemorrhagic Pancreatitis

J. Iovanna, H. Sarles, Z. Berger, 1991, Pancreas.

IER3 in pancreatic carcinogenesis

J. Iovanna, Maria I Molejon, 2015, Oncotarget.