C. Koumenis

发表

Combination of CHEK1/2 Inhibition and Ionizing Radiation Results in Abscopal Tumor Response through Increased Micronuclei Formation

H. Chao, Ilias V. Karagounis, Christoforos Thomas, 2020, Oncogene.

Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis

A. Giaccia, C. Koumenis, Constantinos Koumenis, 1997, Molecular and cellular biology.

Signaling through alternative Integrated Stress Response pathways compensates for GCN2 loss in a mouse model of soft tissue sarcoma

C. Koumenis, S. Ryeom, Stacey L. Lehman, 2015, Scientific Reports.

The PKR-Like Endoplasmic Reticulum Kinase Promotes the Dissemination of Myc-Induced Leukemic Cells

S. Fuchs, C. Koumenis, J. Diehl, 2019, Molecular Cancer Research.

ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

D. Scheuner, R. Kaufman, B. Wouters, 2005, The EMBO journal.

Regulation of autophagy by canonical and non-canonical ER stress responses.

C. Koumenis, M. Bhardwaj, N. Leli, 2019, Seminars in cancer biology.

Regulation of p53 by Hypoxia: Dissociation of Transcriptional Repression and Apoptosis from p53-Dependent Transactivation

Yoichi Taya, Scott W. Lowe, S. Lowe, 2001, Molecular and Cellular Biology.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

Arachidonic acid-induced gene expression in colon cancer cells.

C. Koumenis, F. Chilton, A. Monjazeb, 2006, Carcinogenesis.

HIF-1α and p53: the ODD couple?

C. Koumenis, D. Fels, 2005 .

HIF-1alpha and p53: the ODD couple?

C. Koumenis, D. Fels, 2005, Trends in biochemical sciences.

The Adenoviral E4orf6 Protein Induces Atypical Apoptosis in Response to DNA Damage*

C. Koumenis, Lori S. Hart, D. Ornelles, 2007, Journal of Biological Chemistry.

The Adenovirus E4orf6 Protein Inhibits DNA Double Strand Break Repair and Radiosensitizes Human Tumor Cells in an E1B-55K-independent Manner*

David J. Chen, C. Koumenis, S. Akman, 2005, Journal of Biological Chemistry.

Modulation of CCAAT/Enhancer Binding Protein Homologous Protein (CHOP)-dependent DR5 Expression by Nelfinavir Sensitizes Glioblastoma Multiforme Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL)*

Jiangbin Ye, S. Hahn, X. Tian, 2011, The Journal of Biological Chemistry.

Development of a stress response therapy targeting aggressive prostate cancer

P. Carroll, B. Hann, A. Hsieh, 2018, Science Translational Medicine.

miR-211 is a prosurvival microRNA that regulates chop expression in a PERK-dependent manner.

L. Chodosh, Nancy L. Maas, J. Kushner, 2012, Molecular cell.

Dietary Curcumin Increases Antioxidant Defenses in Lung, Ameliorates Radiation-Induced Pulmonary Fibrosis, and Improves Survival in Mice

K. Cengel, C. Koumenis, C. Solomides, 2010, Radiation research.

Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells.

S. Kridel, C. Koumenis, D. Fels, 2007, Cancer research.

Evaluation of On- and Off-Line Bioluminescence Tomography System for Focal Irradiation Guidance

Ken Kang-Hsin Wang, Iulian I Iordachita, John W Wong, 2016, Radiation Research.

Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress

Jiangbin Ye, C. Koumenis, G. Johannes, 2015, PLoS genetics.

Hypoxia and the unfolded protein response.

A. Koong, Jiangbin Ye, C. Koumenis, 2007, Methods in enzymology.

Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α

N. Sonenberg, B. Wouters, A. Koromilas, 2002, Molecular and Cellular Biology.

The chemopreventive and clinically used agent curcumin sensitizes HPV- but not HPV+ HNSCC to ionizing radiation, in vitro and in a mouse orthotopic model

C. Koumenis, B. O'Malley, Daqing Li, 2012, Cancer biology & therapy.

In Vivo Interrogation of the Hypoxic Transcriptome of Solid Tumors: Optimizing Hypoxic Probe Labeling with Laser Capture Microdissection for Isolation of High-Quality RNA for Deep Sequencing Analysis.

C. Koumenis, V. Popov, L. Brady, 2016, Advances in experimental medicine and biology.

Precision Cardio-Oncology

C. Koumenis, B. Ky, P. Bravo, 2019, The Journal of Nuclear Medicine.

1α,25-Dihydroxyvitamin D3 (calcitriol) and its analogue, 19-nor-1α,25(OH)2D2, potentiate the effects of ionising radiation on human prostate cancer cells

S. Cramer, C. Koumenis, G. Schwartz, 2003, British Journal of Cancer.

A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression

A. Hatzigeorgiou, E. Puré, J. Tobias, 2022, Nature Cell Biology.

Low oxygen stimulates the intellect

C. Koumenis, P. Maxwell, 2006, EMBO reports.

Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation.

A. Giaccia, C. Maki, R. Geyer, 1999, Cancer research.

Transactivation Apoptosis from p 53-Dependent of Transcriptional Repression and Regulation of p 53 by Hypoxia : Dissociation

S. Lowe, P. Sutphin, A. Giaccia, 2001 .

Regulation of Protein Synthesis by Hypoxia via Activation of the Endoplasmic Reticulum Kinase PERK and Phosphorylation of the Translation Initiation Factor eIF2α

N. Sonenberg, B. Wouters, A. Koromilas, 2002, Molecular and Cellular Biology.

Pro-tumorigenic AMPK in glioblastoma

C. Koumenis, N. Leli, 2018, Nature Cell Biology.

ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis.

M. Feldman, S. Fuchs, C. Koumenis, 2015, The Journal of clinical investigation.

Estrogen Receptor β-Mediated Inhibition of Actin-Based Cell Migration Suppresses Metastasis of Inflammatory Breast Cancer

Qi Long, R. Chakrabarti, S. Krishnamurthy, 2021, Cancer Research.

A Novel Mouse Model to Study Image-Guided, Radiation-Induced Intestinal Injury and Preclinical Screening of Radioprotectors.

C. Koumenis, E. Ben-Josef, I. Verginadis, 2017, Cancer research.

Inhibition of Hsp27 radiosensitizes head-and-neck cancer by modulating deoxyribonucleic acid repair.

C. Koumenis, Lori S. Hart, K. Du, 2013, International journal of radiation oncology, biology, physics.

The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth.

C. Koumenis, D. Fels, 2006, Cancer biology & therapy.

Inhibitors of arachidonic acid metabolism act synergistically to signal apoptosis in neoplastic cells.

C. Koumenis, F. Chilton, A. Monjazeb, 2005, Prostaglandins, leukotrienes, and essential fatty acids.

Inhibition of Autophagy as a Strategy to Augment Radiosensitization by the Dual Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Inhibitor NVP-BEZ235

C. Koumenis, A. Maity, R. Rengan, 2012, Molecular Pharmacology.

Assessing the Validity of Clinician Advice That Patients Avoid Use of Topical Agents Before Daily Radiotherapy Treatments

T. Solberg, J. Metz, C. Koumenis, 2018, JAMA oncology.

Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR

D. Welsh, A. Weeraratna, R. Gillies, 2018, Cell.

The role of autophagy as a mechanism of cytotoxicity by the clinically used agent MDA-7/IL-24.

C. Koumenis, Stacey L Lehman, 2010, Cancer biology & therapy.

Inhibition of Autophagy as a Strategy to Augment Radiosensitization by the Dual PI3K/mTOR Inhibitor NVP-BEZ235

C. Koumenis, A. Maity, G. Cerniglia, 2012 .

PERK-ing up autophagy during MYC-induced tumorigenesis

C. Koumenis, Souvik Dey, Feven Tameire, 2013, Autophagy.

Suppression of Type I Interferon Signaling Overcomes Oncogene-Induced Senescence and Mediates Melanoma Development and Progression.

H. Rui, D. Davar, J. Kirkwood, 2016, Cell reports.

An Integrated Stress Response Pathway activates Perivascular Cancer-Associated Fibroblasts to Drive Angiogenesis and Tumor Progression

A. Hatzigeorgiou, E. Puré, J. Tobias, 2020 .

ER stress, hypoxia tolerance and tumor progression.

C. Koumenis, 2006, Current molecular medicine.

Type I interferons mediate pancreatic toxicities of PERK inhibition

J. Kushner, Angela K. Brice, S. Fuchs, 2015, Proceedings of the National Academy of Sciences.

Regulation of intercellular biomolecule transfer-driven tumor angiogenesis and responses to anticancer therapies.

Amy R. Peck, H. Rui, P. Yu, 2021, The Journal of clinical investigation.

Induction of the activating transcription factor-4 in the intratumoral CD8+ T cells sustains their viability and anti-tumor activities

C. Koumenis, J. Diehl, L. Bradley, 2022, Cancer Immunology, Immunotherapy.

State of the Art: Precision Cardio-Oncology

C. Koumenis, B. Ky, Msce, 2019 .

The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1a Phosphorylation

Shannon M. Gallagher-Colombo, S. Vinogradov, R. Sun, 2015 .

19-nor-1α,25-Dihydroxyvitamin D2 (Paricalcitol) inhibits the proliferation of human pancreatic cancer cells in vitro and in vivo

C. Koumenis, Tai-Lin Chen, Christine Naczki, 2008, Cancer biology & therapy.

p27 Kip1 Is Essential for the Antiproliferative Action of 1,25-Dihydroxyvitamin D3 in Primary, but Not Immortalized, Mouse Embryonic Fibroblasts*

M. Willingham, S. Cramer, C. Koumenis, 2002, The Journal of Biological Chemistry.

Loss of AID exacerbates the malignant progression of CLL

C. Koumenis, J. Pinilla-Ibarz, C. Hu, 2022, Leukemia.

Synthetic Secoisolariciresinol Diglucoside (LGM2605) Protects Human Lung in an Ex Vivo Model of Proton Radiation Damage

A. Berman, C. Koumenis, R. Panettieri, 2017, International journal of molecular sciences.

ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma.

K. Flaherty, Dennie T. Frederick, M. Herlyn, 2019, Cancer discovery.

Targeting PARP11 to avert immunosuppression and improve CAR T therapy in solid tumors

P. Yu, A. Minn, S. Fuchs, 2022, Nature Cancer.

ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes.

A. Weljie, C. Koumenis, V. Tomar, 2022, Cell metabolism.

Novel Double-Hit Model of Radiation and Hyperoxia-Induced Oxidative Cell Damage Relevant to Space Travel

C. Koumenis, C. Koch, T. Goodwin, 2016, International journal of molecular sciences.

LGM2605 Reduces Space Radiation-Induced NLRP3 Inflammasome Activation and Damage in In Vitro Lung Vascular Networks

A. Berman, C. Koumenis, M. Christofidou-Solomidou, 2019, International journal of molecular sciences.

GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

C. Thompson, Jiangbin Ye, C. Koumenis, 2015, Genes & development.

The Radiogenomic and Spatiogenomic Landscapes of Glioblastoma, and their Relationship to Oncogenic Drivers

Ashutosh Kumar Singh, Zev A. Binder, S. Bakas, 2022, bioRxiv.

Tumor Microenvironment and Cellular Stress

A. Giaccia, C. Koumenis, E. Hammond, 2014, Advances in Experimental Medicine and Biology.

Controlled cell killing by a recombinant nonsegmented negative-strand RNA virus.

G. Parks, C. Koumenis, V. A. Young, 2002, Virology.

The Chemopreventive Agent Curcumin Is a Potent Radiosensitizer of Human Cervical Tumor Cells via Increased Reactive Oxygen Species Production and Overactivation of the Mitogen-Activated Protein Kinase Pathway

C. Koumenis, Prashanthi Javvadi, S. Tuttle, 2008, Molecular Pharmacology.

Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses

D. Baker, S. Fuchs, C. Koumenis, 2013, Oncogene.

The PERK/eIF2α/ATF4 module of the UPR in hypoxia resistance and tumor growth

C. Koumenis, D. Fels, 2006 .

PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy.

W. Zou, K. Wellen, Jiangbin Ye, 2023, Cell metabolism.

c-Met-mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma.

Lin Zhang, D. O’Rourke, C. Koumenis, 2016, The Journal of clinical investigation.

In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection.

A. Hatzigeorgiou, P. Alexiou, J. Tobias, 2011, Cancer research.

“Translating” Tumor Hypoxia: Unfolded Protein Response (UPR)–Dependent and UPR-Independent Pathways

B. Wouters, C. Koumenis, 2006, Molecular Cancer Research.

YAP1 enhances NF-κB-dependent and independent effects on clock-mediated unfolded protein responses and autophagy in sarcoma

J. Qi, A. Mancuso, C. Koumenis, 2018, Cell Death & Disease.

Wnt-mediated endothelial transformation into mesenchymal stem cell–like cells induces chemoresistance in glioblastoma

Zev A. Binder, Lin Zhang, S. Brem, 2020, Science Translational Medicine.

An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.

H. Rui, J. Kirkwood, P. Lehner, 2019, Cancer cell.

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumor progression

Z. Ignatova, Jiangbin Ye, D. Ruggero, 2019, Nature Cell Biology.

The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

Jiangbin Ye, Haiyan Zhang, C. Koumenis, 2010, The EMBO journal.

Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment.

Amy R. Peck, H. Rui, E. Puré, 2017, Cancer cell.

Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy.

C. Koumenis, I. Verginadis, Feven Tameire, 2015, Seminars in cancer biology.

ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth.

I. Mills, A. Koong, D. Ruggero, 2012, The Journal of clinical investigation.

Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs.

Jianli Wu, J. Lucas, J. Chi, 2012, Cancer research.

Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism

Kyoung-Jae Won, D. Wallace, K. Wellen, 2016, Oncotarget.

Temporal DNA-PK activation drives genomic instability and therapy resistance in glioma stem cells.

Lin Zhang, C. Koumenis, A. Maity, 2018, JCI insight.

Results Time-dependent radioresistance is associated with delayed H 2 AX phosphorylation and DNA repair after radiation in CSCs

Lin Zhang, C. Koumenis, A. Maity, 2018 .

Preferential cytotoxicity of bortezomib toward hypoxic tumor cells via overactivation of endoplasmic reticulum stress pathways.

S. Kridel, A. Koong, Jiangbin Ye, 2008, Cancer research.

Effects of Radiation Quality and Oxygen on Clustered DNA Lesions and Cell Death

R. Stewart, C. Koumenis, A. Georgakilas, 2011, Radiation research.

Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response.

F. Bushman, K. Bittinger, A. Facciabene, 2019, The Journal of clinical investigation.

The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation

Shannon M. Gallagher-Colombo, S. Vinogradov, R. Sun, 2015, Molecular Cancer Therapeutics.

The PI 3 K / Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase ( PDH )-E 1 a Phosphorylation

Shannon M. Gallagher-Colombo, S. Vinogradov, R. Sun, 2015 .

HIF and MIF--a nifty way to delay senescence?

C. Koumenis, A. Maity, 2006, Genes & development.

Control of the hypoxic response through regulation of mRNA translation.

B. Wouters, C. Koumenis, M. Koritzinsky, 2005, Seminars in cell & developmental biology.

Disruption of crosstalk between the fatty acid synthesis and proteasome pathways enhances unfolded protein response signaling and cell death

S. Kridel, C. Koumenis, J. Little, 2008, Molecular Cancer Therapeutics.

Advances in Brief Hypoxia Induces p 53 Accumulation through MDM 2 Down-Regulation and Inhibition of E 6-mediated Degradation 1

A. Giaccia, C. Maki, R. Geyer, 1999 .

Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation.

M. Brechbiel, C. Koumenis, K. Brown, 2005, Blood.

Identification and Characterization of a Potent Activator of p53-Independent Cellular Senescence via a Small-Molecule Screen for Modifiers of the Integrated Stress Response

Nancy L. Maas, A. Koong, C. Koumenis, 2013, Molecular Pharmacology.

Identification and Characterization of a Potent Activator of p53-Independent Cellular Senescence via a Small-Molecule Screen for Modifiers of the Integrated Stress Response s

Nancy L. Maas, A. Koong, C. Koumenis, 2013 .

Microsoft Word-12278828-file00.docx

Nancy L. Maas, A. Koong, C. Koumenis, 2012 .

Dual PI3K/mTOR inhibitor NVP-BEZ235 suppresses hypoxia-inducible factor (HIF)-1α expression by blocking protein translation and increases cell death under hypoxia

C. Koumenis, A. Maity, G. Cerniglia, 2012, Cancer biology & therapy.

AMPK Activation and Metabolic Reprogramming by Tamoxifen through Estrogen Receptor-Independent Mechanisms Suggests New Uses for This Therapeutic Modality in Cancer Treatment.

C. Koumenis, I. Blair, N. Snyder, 2016, Cancer research.

Key biological mechanisms involved in high-LET radiation therapies with a focus on DNA damage and repair

C. Koumenis, V. Gorgoulis, A. Georgakilas, 2022, Expert Reviews in Molecular Medicine.

Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.

M. Herlyn, Gao Zhang, C. Koumenis, 2014, The Journal of clinical investigation.

Identification and biological evaluation of a novel and potent small molecule radiation sensitizer via an unbiased screen of a chemical library.

S. Kridel, C. Koumenis, G. Kao, 2007, Cancer research.

Pancreatic cancer cells express 25-hydroxyvitamin D-1α-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3

M. Willingham, M. Holick, S. Cramer, 2004 .

Piling up the JNK: Drug synergy through ER stress

C. Koumenis, L. Hertan, 2009, Cancer biology & therapy.

Radiation Mitigating Properties of Intranasally Administered KL4 Surfactant in a Murine Model of Radiation-Induced Lung Damage

C. Koumenis, R. Segal, M. Christofidou-Solomidou, 2017, Radiation Research.

Transcriptome analysis of hypoxic cancer cells uncovers intron retention in EIF2B5 as a mechanism to inhibit translation

M. Ivan, C. Ivan, C. Koumenis, 2017, PLoS biology.

A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α–XBP1 Activation

P. Khatri, A. Koong, A. Giaccia, 2018, Molecular Cancer Research.

The Unfolded Protein Response and Therapeutic Opportunities

C. Koumenis, Souvik Dey, C. Sayers, 2014 .

Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab

J. Christensen, W. El-Deiry, D. Dicker, 2011, Cell cycle.

Radiosensitization by the PARP inhibitor olaparib in BRCA1-proficient and deficient high-grade serous ovarian carcinomas.

C. Koumenis, Souvik Dey, Linlang Guo, 2018, Gynecologic oncology.

PERK-dependent regulation of MDA-7/IL-24-induced autophagy in primary human glioma cells

P. Fisher, S. Spiegel, P. Dent, 2008, Autophagy.

A PERK–miR-211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival

C. Dang, D. Ruggero, S. McMahon, 2017, Nature Cell Biology.

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

Jiangbin Ye, C. Koumenis, J. Diehl, 2010, Oncogene.

Activation of p38α stress-activated protein kinase drives the formation of the pre-metastatic niche in the lungs

E. Puré, T. Mak, J. Kirkwood, 2020, Nature Cancer.

Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

P. Lambin, N. Sonenberg, J. Voncken, 2006, The EMBO journal.

ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis.

Jiangbin Ye, C. Koumenis, 2009, Current molecular medicine.

Induction of the activating transcription factor-4 in the intratumoral CD8+ T cells sustains their viability and anti-tumor activities

C. Koumenis, J. Diehl, L. Bradley, 2022, Cancer Immunology, Immunotherapy.

A PERK-miR211 axis suppresses circadian regulators and protein synthesis to promote cancer cell survival

G. Wertheim, C. Dang, D. Ruggero, 2017, Nature Cell Biology.

Microenvironment and Immunology In Vivo Profiling of Hypoxic Gene Expression in Gliomas Using the Hypoxia Marker EF 5 and Laser-capture Microdissection

A. Hatzigeorgiou, P. Alexiou, J. Tobias, 2011 .

FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response

Gwendolyn M. Cramer, A. Hatzigeorgiou, J. Metz, 2021, Cancer Research.

Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells.

C. Koumenis, R. Mick, Rachelle E. Kosoff, 2010, Cancer research.

PERK-dependent regulation of HSP70 expression and the regulation of autophagy

P. Fisher, C. Chen, P. Dent, 2008, Autophagy.

The heat shock proteins as targets for radiosensitization and chemosensitization in cancer

C. Koumenis, D. Guttmann, 2011, Cancer biology & therapy.

Roadmap for precision preclinical x-ray radiation studies

L. Dubois, D. de Ruysscher, F. Verhaegen, 2022, Physics in medicine and biology.

Role of p38 Protein Kinase in the Ligand-independent Ubiquitination and Down-regulation of the IFNAR1 Chain of Type I Interferon Receptor*

D. Baker, S. Fuchs, C. Koumenis, 2011, The Journal of Biological Chemistry.

Inducible Priming Phosphorylation Promotes Ligand-independent Degradation of the IFNAR1 Chain of Type I Interferon Receptor*

D. Baker, C. Koumenis, J. Diehl, 2009, The Journal of Biological Chemistry.

A Novel Mouse Model of Radiation-Induced Cardiac Injury Reveals Biological and Radiological Biomarkers of Cardiac Dysfunction with Potential Clinical Relevance

S. Feigenberg, C. Koumenis, B. Ky, 2021, Clinical Cancer Research.

Avoiding antiperspirants during breast radiation therapy: Myth or sound advice?

T. Solberg, J. Metz, C. Koumenis, 2017, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Pro-tumorigenic AMPK in glioblastoma

C. Koumenis, N. Leli, 2018, Nature Cell Biology.

The Use of a Reversible Transcription Inhibitor, DRB, to Investigate the Involvement of Specific Proteins in the Ocular Circadian System of Aplysia

C. Koumenis, A. Eskin, Quang Tran, 1996, Journal of biological rhythms.

Identification of Three Proteins in the Eye of Aplysia, Whose Synthesis Is Altered by Serotonin (5-HT). POSSIBLE INVOLVEMENT OF THESE PROTEINS IN THE OCULAR CIRCADIAN SYSTEM (*)

R. Cook, C. Koumenis, C. Koumenis, 1995, The Journal of Biological Chemistry.

Editorial :Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). DOI: 10.1080/15548627.2015.1100356;WOS:000373595400001; 2-s2.0-85013763791&;PMID: 26799652

Lee, Duchen, Izzo, 2016 .

The Adenovirus E 4 orf 6 Protein Inhibits DNA Double Strand Break Repair and Radiosensitizes Human Tumor Cells in an E 1 B-55 K-independent Manner *

David J. Chen, C. Koumenis, S. Akman, 2004 .

Chemotherapy, Tumor Microenvironment, and Apoptosis

A. Giaccia, C. Koumenis, N. Denko, 1999 .

Interleukin 6 Signaling Blockade Exacerbates Acute and Late Injury From Focal Intestinal Irradiation.

E. Puré, C. Koumenis, E. Ben-Josef, 2019, International journal of radiation oncology, biology, physics.

Vitamin D Receptor and p21/WAF1 Are Targets of Genistein and 1,25-Dihydroxyvitamin D3 in Human Prostate Cancer Cells

J. Welsh, S. Cramer, C. Koumenis, 2004, Cancer Research.

Vitamin D Receptor and p 21 / WAF 1 Are Targets of Genistein and 1 , 25-Dihydroxyvitamin D 3 in Human Prostate Cancer Cells

J. Welsh, S. Cramer, C. Koumenis, 2004 .

Loss of p19Arf promotes fibroblast survival during leucine deprivation

E. Puré, C. Koumenis, J. M. Posimo, 2022, Biology open.

Updates on radiotherapy-immunotherapy combinations: Proceedings of 6th annual ImmunoRad conference

R. Weichselbaum, R. Timmerman, J. Welsh, 2023, Oncoimmunology.

Modeling ultra-high dose rate electron and proton FLASH effect with the physicochemical approach

C. Koumenis, H. Tan, K. Teo, 2023, Physics in medicine and biology.

Cancer Therapy and Tumor Physiology

A. Giaccia, C. Koumenis, N. Denko, 1998, Science.

The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction.

A. Giaccia, J. Brown, C. Koumenis, 1996, Proceedings of the National Academy of Sciences of the United States of America.

A Novel Ubiquitin Complex Regulates Aneuploid Epithelial Tumors by Moderating an Integrated Stress Response.

C. Koumenis, N. Leli, 2023, Cancer discovery.

p53 promotes selection for Fas-mediated apoptotic resistance.

A. Giaccia, H. Maecker, C. Koumenis, 2000, Cancer research.

Author Correction: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

Z. Ignatova, Jiangbin Ye, D. Ruggero, 2019, Nature Cell Biology.

Cell intrinsic and extrinsic activators of the unfolded protein response in cancer: Mechanisms and targets for therapy.

C. Koumenis, I. Verginadis, Feven Tameire, 2015, Seminars in cancer biology.

Targeting ER stress-induced autophagy overcomes BRAF inhibitor resistance in melanoma.

M. Herlyn, Gao Zhang, C. Koumenis, 2014, The Journal of clinical investigation.

Thioredoxin reductase-1 mediates curcumin-induced radiosensitization of squamous carcinoma cells.

C. Koumenis, R. Mick, Rachelle E. Kosoff, 2010, Cancer research.

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

C. Koumenis, J. Diehl, E. Bobrovnikova-Marjon, 2010, Oncogene.

Location, Location, Location-Makes All the Difference for Hypoxia in Lung Tumors

C. Koumenis, A. Maity, 2010, Clinical Cancer Research.

Paricalcitol has a potent in vivo tumoricidal effect on head and neck squamous cell carcinoma

C. Koumenis, S. Hess, T.-S. W. Huang, 2005 .

Intercellular pathways of cancer treatment-related cardiotoxicity and their therapeutic implications: The paradigm of radiotherapy.

Hamid Khoshfekr Rudsari, I. Balasingham, Athanasia Pavlopoulou, 2024, Pharmacology & therapeutics.

Shining a FLASHlight on ultrahigh dose rate radiation and possible late toxicity.

A. Maity, C. Koumenis, 2022, Clinical Cancer Research.

Proton FLASH Radiotherapy Ameliorates Radiation-induced Salivary Gland Dysfunction and Oral Mucositis and Increases Survival in a Mouse Model of Head and Neck Cancer

K. Cengel, F. Vander Stappen, C. Koumenis, 2024, Molecular cancer therapeutics.

Targeting stress induction of GRP78 by cardiac glycoside oleandrin dually suppresses cancer and COVID-19

C. Koumenis, N. Leli, S. Mumenthaler, 2024, Cell & bioscience.

Parkin Deficiency Suppresses Antigen Presentation to Promote Tumor Immune Evasion and Immunotherapy Resistance

A. Hatzigeorgiou, M. Lotze, A. Facciabene, 2023, Cancer research.

Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies

C. Koumenis, Y. Fujimura, E. Bolotin, 2024, Science Translational Medicine.

FLASH Proton Radiation Therapy Mitigates Inflammatory and Fibrotic Pathways and Preserves Cardiac Function in a Preclinical Mouse Model of Radiation-Induced Heart Disease

A. Hatzigeorgiou, K. Cengel, C. Koumenis, 2024, International journal of radiation oncology, biology, physics.

Integrating imaging and genomic data for the discovery of distinct glioblastoma subtypes: a joint learning approach

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An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma

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p53 promotes revival stem cells in the regenerating intestine after severe radiation injury

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