K. Freier

发表

Targeting irradiation‐induced mitogen‐activated protein kinase activation in vitro and in an ex vivo model for human head and neck cancer

W. Weichert, A. Stenzinger, A. Affolter, 2016, Head & neck.

Reconstruction of severely atrophied alveolar ridges with calvarial onlay bone grafts and dental implants.

K. Freier, H. Steveling, J. Hoffmann, 2011, Clinical implant dentistry and related research.

Neoadjuvant concurrent radiochemotherapy followed by surgery in advanced oral squamous cell carcinoma (OSCC): a retrospective analysis of 207 patients.

J. Mühling, S. Haßfeld, C. Flechtenmacher, 2007, Oral oncology.

Somatic mutations and promotor methylation of the ryanodine receptor 2 is a common event in the pathogenesis of head and neck cancer

R. Eils, C. Plass, W. Weichert, 2019, International journal of cancer.

Frequent high telomerase reverse transcriptase expression in primary oral squamous cell carcinoma.

P. Lichter, F. Bosch, C. Flechtenmacher, 2007, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

Loss of SOX2 expression induces cell motility via vimentin up‐regulation and is an unfavorable risk factor for survival of head and neck squamous cell carcinoma

J. Debus, W. Weichert, A. Stenzinger, 2015, Molecular oncology.

Acinar cell carcinomas of the pancreas: a molecular analysis in a series of 57 cases

M. Kloor, P. Schirmacher, D. Capper, 2014, Virchows Archiv.

Unraveling most abundant mutational signatures in head and neck cancer

W. Weichert, K. Zaoui, K. Freier, 2020, International journal of cancer.

Ki-67 expression predicts radiosensitivity in oral squamous cell carcinoma.

J. Hoffmann, K. Freier, M. Engel, 2012, International journal of oral and maxillofacial surgery.

p16INK4a/Ki‐67 co‐expression specifically identifies transformed cells in the head and neck region

M. von Knebel Doeberitz, K. Freier, P. Plinkert, 2015, International journal of cancer.

Organotypic Co-Cultures as a Novel 3D Model for Head and Neck Squamous Cell Carcinoma

M. von Knebel Doeberitz, N. Grabe, N. Rotter, 2020, Cancers.

Intensity Modulated Radiotherapy (IMRT) + Carbon Ion Boost for Adenoid Cystic Carcinoma of the Minor Salivary Glands in the Oral Cavity

J. Debus, K. Freier, P. Plinkert, 2018, Cancers.

High-LET radiotherapy for adenoid cystic carcinoma of the head and neck: 15 years' experience with raster-scanned carbon ion therapy.

J. Debus, M. Münter, K. Freier, 2016, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Prospective feasibility analysis of salvage surgery in recurrent oral cancer in terms of quality of life.

K. Freier, J. Krisam, J. Hoffmann, 2020, Oral oncology.

Definitive radiotherapy vs. postoperative radiotherapy for lower gingival carcinomas of the mandible

J. Debus, K. Freier, S. Akbaba, 2019, Strahlentherapie und Onkologie.

Cranio-maxillofacial non-Hodgkin's lymphoma: clinical and histological presentation.

K. Freier, J. Hoffmann, R. Seeberger, 2012, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

Interdisciplinary combined treatment of craniofacial osteosarcoma with neoadjuvant and adjuvant chemotherapy and excision of the tumour: a retrospective study.

K. Freier, G. Egerer, C. Hofele, 2008, The British journal of oral & maxillofacial surgery.

IDO1 is highly expressed in macrophages of patients in advanced tumour stages of oral squamous cell carcinoma

K. Roemer, K. Freier, J. Hess, 2022, Journal of Cancer Research and Clinical Oncology.

Haemangiopericytoma of the mandible.

J. Mühling, C. Flechtenmacher, K. Freier, 2010, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

Recurrent NMYC copy number gain and high protein expression in basal cell carcinoma.

P. Lichter, C. Flechtenmacher, S. Joos, 2006, Oncology reports.

TREM2 Is Associated with Advanced Stages and Inferior Prognosis in Oral Squamous Cell Carcinoma

K. Roemer, K. Freier, J. Hess, 2022, Cancers.

Neck involvement and disease recurrence in adenoid cystic carcinoma of the minor salivary glands: the role of surgery in primary and progressive disease.

J. Hoffmann, K. Freier, C. Hofele, 2020, International journal of oral and maxillofacial surgery.

Carbon ion therapy (C12) for high-grade malignant salivary gland tumors (MSGTs) of the head and neck: do non-ACCs profit from dose escalation?

J. Debus, K. Freier, N. Chaudhri, 2016, Radiation Oncology.

The Phase I/II ACCEPT Trial: Concurrent Cetuximab and Intensity-Modulated Radiotherapy with Carbon Ion Boost for Adenoid Cystic Carcinoma of the Head and Neck: Cetuximab and IMRT/Carbon Ions for ACC.

J. Debus, K. Herfarth, M. Münter, 2019, International journal of radiation oncology, biology, physics.

Copy number gains on 22q13 in adenoid cystic carcinoma of the salivary gland revealed by comparative genomic hybridization and tissue microarray analysis.

S. Haßfeld, A. Walch, P. Lichter, 2005, Cancer genetics and cytogenetics.

Trigonocephaly: results after surgical correction of nonsyndromatic isolated metopic suture synostosis in 54 cases.

J. Mühling, K. Freier, J. Hoffmann, 2012, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

Carbon ion therapy (C12) for high-grade malignant salivary gland tumors (MSGTs) of the head and neck: do non-ACCs profit from dose escalation?

J. Debus, K. Freier, N. Chaudhri, 2016, Radiation oncology.

Multiple Sequential Free Flap Reconstructions of the Head and Neck: A Single-Center Experience

K. Freier, J. Hoffmann, O. Ristow, 2021, Plastic and reconstructive surgery.

A comparison of free anterolateral thigh and latissimus dorsi flaps in soft tissue reconstruction of extensive defects in the head and neck region.

K. Freier, J. Hoffmann, M. Engel, 2014, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

Free Vastus Intermedius Muscle Flap: A Successful Alternative for Complex Reconstruction of the Neurocranium in Preoperated Patients

O. Sakowitz, K. Freier, J. Hoffmann, 2017, The Journal of craniofacial surgery.

Prognostic Gene Signature for Squamous Cell Carcinoma with a Higher Risk for Treatment Failure and Accelerated MEK-ERK Pathway Activity

W. Weichert, E. Herpel, K. Zaoui, 2021, Cancers.

Intermediate short-term tourniquet use during the preparation of a free vascularised fibula flap for mandibular reconstruction. A case report.

K. Freier, O. Thiele, R. Simon, 2008, Minerva stomatologica.

Changes after surgically-assisted maxillary expansion (SARME) to the dentoalveolar, palatal and nasal structures by using tooth-borne distraction devices.

K. Freier, R. Seeberger, R. Davids, 2011, The British journal of oral & maxillofacial surgery.

[Surgically assisted rapid maxillary expansion. Effects on the nasal airways and nasal septum].

K. Freier, C. Hofele, R. Seeberger, 2010, HNO.

Recurrent Craniofacial Dermatofibrosarcoma Protuberans: Long-term Prognosis After Close Surgical Removal

J. Mühling, K. Freier, R. Seeberger, 2009, The Journal of craniofacial surgery.

Full-Thickness Tumor Resection of Oral Cancer Involving the Facial Skin—Microsurgical Reconstruction of Extensive Defects after Radical Treatment of Advanced Squamous Cell Carcinoma

J. Hoffmann, K. Freier, O. Ristow, 2021, Cancers.

Long-term donor site morbidity in head and neck cancer patients and its impact on quality of life: a cross-sectional study.

K. Freier, J. Hoffmann, C. Mertens, 2019, International journal of oral and maxillofacial surgery.

Survival of Patients with Oral Cavity Cancer in Germany

Stefan Listl, Bernd Holleczek, Hermann Brenner, 2013, PloS one.

Do Functional Scores of Flap Donor Sites Recover After Reconstruction of Segmental Jaw Defects?

K. Freier, J. Hoffmann, C. Mertens, 2019, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

Subjective and objective appearance of head and neck cancer patients following microsurgical reconstruction and associated quality of life─A cross-sectional study.

K. Freier, J. Hoffmann, C. Mertens, 2018, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

The use of self-inflating soft tissue expanders prior to bone augmentation of atrophied alveolar ridges.

K. Freier, J. Hoffmann, C. Mertens, 2015, Clinical implant dentistry and related research.

Changes in the mandibular and dento-alveolar structures by the use of tooth borne mandibular symphyseal distraction devices.

K. Freier, R. Seeberger, C. Hofele, 2011, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

Recurrent copy number gain of transcription factor SOX2 and corresponding high protein expression in oral squamous cell carcinoma

P. Lichter, C. Flechtenmacher, S. Joos, 2010, Genes, chromosomes & cancer.

The role of human papillomavirus in oral squamous cell carcinoma: myth and reality

K. Freier, K. Kansy, O. Thiele, 2014, Oral and Maxillofacial Surgery.

Craniofacial metastases: a 20-year survey.

C. Flechtenmacher, K. Freier, R. Seeberger, 2011, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

K. Freier, D. Danner, A. Hassel, 2012, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

Differential KIT expression in histological subtypes of adenoid cystic carcinoma (ACC) of the salivary gland.

J. Mühling, A. Walch, P. Lichter, 2005, Oral oncology.

Integrative Analysis of Multi-omics Data Identified EGFR and PTGS2 as Key Nodes in a Gene Regulatory Network Related to Immune Phenotypes in Head and Neck Cancer

R. Eils, W. Weichert, K. Zaoui, 2020, Clinical Cancer Research.

Tissue microarray analysis reveals site-specific prevalence of oncogene amplifications in head and neck squamous cell carcinoma.

Axel Benner, Stefan Joos, Kolja Freier, 2003, Cancer research.

Upregulation of PD‐L1 and PD‐L2 in neck node metastases of head and neck squamous cell carcinoma

E. Herpel, K. Freier, J. Hess, 2019, Head & neck.

Is panendoscopy a necessary staging procedure in patients with lacking risk factors and oral squamous cell carcinoma?

K. Freier, J. Hoffmann, O. Ristow, 2019, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

High survivin expression is associated with favorable outcome in advanced primary oral squamous cell carcinoma after radiation therapy

P. Lichter, C. Flechtenmacher, S. Joos, 2007, International journal of cancer.

A six-gene expression signature related to angiolymphatic invasion is associated with poor survival in laryngeal squamous cell carcinoma

K. Zaoui, K. Freier, J. Hess, 2020, European Archives of Oto-Rhino-Laryngology.

Diagnostic imaging in the management of craniosynostoses

Joachim Mühling, Bibiana Kotrikova, Kolja Freier, 2007, European Radiology.

Maxillary sinus-floor elevation with nanoporous biphasic bone graft material for early implant placement.

K. Freier, A. Sander, D. Wiens, 2014, Clinical implant dentistry and related research.

Development of the clinical use of distant flaps for head and neck reconstruction.

K. Freier, J. Hoffmann, R. Seeberger, 2014, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

The role of elective supraomohyoidal neck dissection in the treatment of early, node-negative oral squamous cell carcinoma (OSCC): a retrospective analysis of 122 cases.

C. Flechtenmacher, K. Freier, R. Seeberger, 2012, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

Ectopic wisdom tooth at the mandibular ascending ramus

K. Freier, J. Hoffmann, C. Staff, 2014 .

Targeting EGFR-PI3K-AKT-mTOR signaling enhances radiosensitivity in head and neck squamous cell carcinoma

K. Freier, J. Hess, J. Hoffmann, 2015, Expert opinion on therapeutic targets.

The value of prebent reconstruction plates and in-house 3D printing.

K. Freier, O. Ristow, M. Engel, 2023, Journal of stomatology, oral and maxillofacial surgery.

Recurrent FGFR1 amplification and high FGFR1 protein expression in oral squamous cell carcinoma (OSCC).

J. Mühling, P. Lichter, C. Schwaenen, 2007, Oral oncology.

Activation of MAP kinase signaling through ERK5 but not ERK1 expression is associated with lymph node metastases in oral squamous cell carcinoma (OSCC).

Stefan Joos, Carsten Sticht, Kolja Freier, 2008, Neoplasia.

Cytogenetic characterization of head and neck squamous cell carcinoma cell lines as model systems for the functional analyses of tumor-associated genes.

P. Lichter, K. Freier, P. Plinkert, 2010, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

Lack of evidence of human papillomavirus-induced squamous cell carcinomas of the oral cavity in southern Germany.

M. von Knebel Doeberitz, S. Reinert, C. Flechtenmacher, 2013, Oral oncology.

Phosphorylation of AKT(Ser473) serves as an independent prognostic marker for radiosensitivity in advanced head and neck squamous cell carcinoma

W. Weichert, N. Grabe, Sarika Sharma, 2015, International journal of cancer.

The localization and risk factors of squamous cell carcinoma in the oral cavity: A retrospective study of 1501 cases.

L. Uhlmann, K. Freier, J. Hoffmann, 2017, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

Occurrence of cervical lymph node metastasis of maxillary squamous cell carcinoma - A monocentric study of 171 patients.

J. Hoffmann, K. Freier, O. Ristow, 2015, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

Upregulation of pAKT(Ser473) expression in progression of HPV‐positive oropharyngeal squamous cell carcinoma

K. Freier, P. Plinkert, J. Hess, 2017, Head & neck.

Disease control and functional outcome in three modern combined organ preserving regimens for locally advanced squamous cell carcinoma of the head and neck (SCCHN)

W. Weichert, J. Debus, M. Münter, 2011, Radiation oncology.

Age-dependent hemato- and nephrotoxicity in patients with head and neck cancer receiving chemoradiotherapy with weekly cisplatin

J. Debus, K. Zaoui, K. Freier, 2019, Strahlentherapie und Onkologie.

Cetuximab and radiation for primary and recurrent squamous cell carcinoma of the head and neck (SCCHN) in the elderly and multi-morbid patient: a single-centre experience

J. Debus, M. Münter, K. Freier, 2010, Head & neck oncology.

Reconstruction of the severely atrophic edentulous maxillae with calvarial bone grafts

K. Freier, J. Krisam, J. Hoffmann, 2017, Clinical oral implants research.

Early bone resorption after vertical bone augmentation--a comparison of calvarial and iliac grafts.

K. Freier, A. Sander, J. Hoffmann, 2013, Clinical oral implants research.

Early bone resorption of free microvascular reanastomized bone grafts for mandibular reconstruction--a comparison of iliac crest and fibula grafts.

K. Freier, A. Sander, J. Hoffmann, 2014, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

High 2-[18F]fluoro-2-deoxy-d-glucose (18FDG) uptake measured by positron emission tomography is associated with reduced overall survival in patients with oral squamous cell carcinoma.

U. Haberkorn, K. Freier, I. Buchmann, 2009, Oral oncology.

Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC)

P. Lichter, F. Bosch, C. Flechtenmacher, 2005, British Journal of Cancer.

The prognostic significance of the lymph node ratio in oral cancer differs for anatomical subsites.

J. Hoffmann, C. Flechtenmacher, K. Freier, 2019, International journal of oral and maxillofacial surgery.

Solitary infantile myofibroma of the skull.

J. Hoffmann, K. Freier, G. Mechtersheimer, 2011, The Journal of craniofacial surgery.

Recurrent coamplification of cytoskeleton‐associated genes EMS1 and SHANK2 with CCND1 in oral squamous cell carcinoma

P. Lichter, D. Stange, C. Flechtenmacher, 2006, Genes, chromosomes & cancer.

Clinical outcome and prognostic factors in recurrent oral squamous cell carcinoma after primary surgical treatment: a retrospective study

K. Freier, J. Hoffmann, O. Ristow, 2021, Clinical Oral Investigations.

Outcome of heavily pretreated recurrent oral squamous cell carcinoma after salvage resection: A monocentric retrospective analysis.

W. Weichert, K. Freier, J. Hoffmann, 2016, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

IDO1 is highly expressed in macrophages of patients in advanced tumour stages of oral squamous cell carcinoma

K. Roemer, K. Freier, J. Hess, 2022, Journal of Cancer Research and Clinical Oncology.

Reconstruction of the maxilla following hemimaxillectomy defects with scapular tip grafts and dental implants.

K. Freier, J. Hoffmann, C. Mertens, 2016, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

Adjuvant Radiotherapy in Patients with Squamous Cell Carcinoma of the Oral Cavity or Oropharynx and Solitary Ipsilateral Lymph Node Metastasis (pN1)—A Prospective Multicentric Cohort Study

F. Hölzle, K. Wolff, S. Hoefert, 2023, Cancers.

Comparative expressed sequence hybridization detects recurrent patterns of altered sequence expression in oral squamous cell carcinoma.

P. Lichter, S. Joos, K. Freier, 2010, Oncology reports.

Digital Pathology Scoring of Immunohistochemical Staining Reliably Identifies Prognostic Markers and Anatomical Associations in a Large Cohort of Oral Cancers

S. Fröhling, D. Jäger, A. Mock, 2021, Frontiers in Oncology.

The occurrence of cervical metastases in squamous cell carcinoma of the tongue: Is there a rationale for bilateral neck dissection in early-stage tumors?

K. Freier, J. Hoffmann, M. Engel, 2019, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

Use of stereolithographic cutting guides in corrective (wedge) Lefort I osteotomy.

K. Freier, R. Seeberger, O. Thiele, 2011, British Journal of Oral and Maxillofacial Surgery.

Distinct site-specific oncoprotein overexpression in head and neck squamous cell carcinoma: a tissue microarray analysis.

P. Lichter, A. Benner, F. Bosch, 2003, Anticancer research.

[Opportunities and chances for tissue chip microarrays in head and neck surgery. A novel technique for the rapid evaluation of potentially novel biomarkers].

J. Mühling, P. Lichter, F. Bosch, 2002, Mund-, Kiefer- und Gesichtschirurgie : MKG.

Cortactin expression: Association with disease progression and survival in oral squamous cell carcinoma

W. Weichert, P. Lichter, N. Grabe, 2018, Head & neck.

Treatment delay in early-stage oral squamous cell carcinoma and its relation to survival.

K. Freier, J. Hoffmann, O. Ristow, 2021, Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery.

Free-Flap Reconstruction in Early-Stage Squamous Cell Carcinoma of the Oral Cavity—A Prospective Monocentric Trial to Evaluate Oncological Outcome and Quality of Life

K. Freier, O. Ristow, M. Engel, 2023, Journal of clinical medicine.

Definitive radiotherapy vs. postoperative radiotherapy for lower gingival carcinomas of the mandible

J. Debus, K. Freier, S. Akbaba, 2019, Strahlentherapie und Onkologie.

Dynamic Up-Regulation of PD-L1 in the Progression of Oral Squamous Cell Carcinoma

K. Freier, C. Freudlsperger, D. Horn, 2023, International journal of molecular sciences.