D. Simpson

发表

Gene expression signatures but not cell cycle checkpoint functions distinguish AT carriers from normal individuals.

P. Bushel, R. Paules, J. Chou, 2013, Physiological genomics.

Ataxia Telangiectasia-Mutated–Dependent DNA Damage Checkpoint Functions Regulate Gene Expression in Human Fibroblasts

P. Bushel, R. Paules, J. Chou, 2007, Molecular Cancer Research.

Telomerase expression is sufficient for chromosomal integrity in cells lacking p53 dependent G1 checkpoint function

E. Livanos, W. Kaufmann, D. Simpson, 2005, Journal of carcinogenesis.

Profiles of Global Gene Expression in Ionizing-Radiation–Damaged Human Diploid Fibroblasts Reveal Synchronization behind the G1 Checkpoint in a G0-like State of Quiescence

Pierre R. Bushel, Thomas E. Mullen, Richard S. Paules, 2005, Environmental health perspectives.

Cell cycle checkpoint function in bladder cancer.

James J. Yoo, A. Atala, W. Kaufmann, 2003, Journal of the National Cancer Institute.

Deduced consensus sequence of Sindbis virus strain AR339: mutations contained in laboratory strains which affect cell culture and in vivo phenotypes

R. Johnston, D. Simpson, S. C. Lin, 1996, Journal of virology.

Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells

Joseph G. Ibrahim, Matthew A Psioda, Charles M. Perou, 2017, npj Breast Cancer.

Degradation of ATM-Independent Decatenation Checkpoint Function in Human Cells is Secondary to Inactivation of p53 and Correlated with Chromosomal Destabilization

W. Kaufmann, D. Simpson, D. Galloway, 2002, Cell cycle.

Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblasts

S. Smith‐Roe, J. Ibrahim, W. Kaufmann, 2011, Cell cycle.

In Silico Construction of a Protein Interaction Landscape for Nucleotide Excision Repair

J. Ibrahim, Charles Schmitt, W. Kaufmann, 2009, Cell Biochemistry and Biophysics.

The Epstein-Barr Virus Immediate-Early Protein BZLF1 Induces both a G2 and a Mitotic Block

W. Kaufmann, S. Kenney, D. Simpson, 2002, Journal of Virology.

An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage

Richard S. Paules, William K. Kaufmann, Alexandra N. Heinloth, 2002, Molecular and Cellular Biology.

Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblasts

S. Smith‐Roe, J. Ibrahim, W. Kaufmann, 2013, Cell cycle.

Human papilloma virus type16 E6 deregulates CHK1 and sensitizes human fibroblasts to environmental carcinogens independently of its effect on p53

W. Kaufmann, D. Simpson, Yingchun Zhou, 2009, Cell cycle.

Cdc7-Dbf4 and the Human S Checkpoint Response to UVC*

R. Paules, W. Kaufmann, D. Simpson, 2007, Journal of Biological Chemistry.

p53-Dependent but ATM-independent inhibition of DNA synthesis and G2 arrest in cadmium-treated human fibroblasts.

T. Jin, W. Kaufmann, D. Simpson, 2007, Toxicology and applied pharmacology.

A Flexible and Qualitatively Stable Model for Cell Cycle Dynamics Including DNA Damage Effects

C. R. Johnson, C. Jeffries, W. Kaufmann, 2012, Gene regulation and systems biology.

A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability.

Lisle E. Mose, J. Parker, J. Reis-Filho, 2020, Cell reports.

ATM-dependent DNA damage checkpoint functions regulate gene expression in human fibroblasts

R. Paules, J. Chou, W. Kaufmann, 2013 .

Vaccinia virus gene A18R encodes an essential DNA helicase

R. Condit, D. Simpson, 1995, Journal of virology.

The vaccinia virus A18R protein plays a role in viral transcription during both the early and the late phases of infection

R. Condit, D. Simpson, 1994, Journal of virology.

An Attenuating Mutation in nsP1 of the Sindbis-Group Virus S.A.AR86 Accelerates Nonstructural Protein Processing and Up-Regulates Viral 26S RNA Synthesis

R. Johnston, M. Heise, D. Simpson, 2003, Journal of Virology.

Influenza virus ts61S hemagglutinin is significantly defective in polypeptide folding and intracellular transport at the permissive temperature.

R. Lamb, D. Simpson, 1991, Virology.

Topoisomerase IIα maintains genomic stability through decatenation G2 checkpoint signaling

G. Karaca, W. Kaufmann, D. Simpson, 2010, Oncogene.

Revised genetic requirements for the decatenation G2 checkpoint: The role of ATM

R. Paules, W. Kaufmann, D. Simpson, 2010, Cell cycle.

Alterations to influenza virus hemagglutinin cytoplasmic tail modulate virus infectivity

R. Lamb, D. Simpson, 1992, Journal of virology.

Synthesis, stability, and cleavage of Newcastle disease virus glycoproteins in the absence of glycosylation

D. Simpson, T. Morrison, 1980, Journal of virology.

Marker-free quantification of repair pathway utilization at Cas9-induced double-strand breaks

G. Gupta, D. Ramsden, D. Simpson, 2021, Nucleic acids research.

Genetic determinants of cellular addiction to DNA polymerase theta

Lisle E. Mose, J. Parker, G. Gupta, 2019, Nature Communications.

Complete nucleotide sequence and full-length cDNA clone of S.A.AR86 a South African alphavirus related to Sindbis.

R. Johnston, D. Simpson, S. C. Lin, 1996, Virology.

Radiation clastogenesis and cell cycle checkpoint function as functional markers of breast cancer risk.

R. Millikan, L. Carey, W. Kaufmann, 2006, Carcinogenesis.

Caffeine and human DNA metabolism: the magic and the mystery.

L. Beaulieu, W. Kaufmann, D. Simpson, 2003, Mutation research.

Targeting Non-homologous and Alternative End Joining Repair to Enhance Cancer Radiosensitivity.

G. Gupta, D. Simpson, W. Feng, 2022, Seminars in radiation oncology.

Identification of Primary Transcriptional Regulation of Cell Cycle-Regulated Genes upon DNA Damage

P. Hurban, R. Elkon, E. Lobenhofer, 2007, Cell cycle.

Effective intra‐S checkpoint responses to UVC in primary human melanocytes and melanoma cell lines

J. Ibrahim, W. Kaufmann, D. Simpson, 2016, Pigment cell & melanoma research.

Overproduction of DNA polymerase eta does not raise the spontaneous mutation rate in diploid human fibroblasts.

W. Kaufmann, D. Simpson, T. Heffernan, 2005, DNA repair.

A prognostic signature of G₂ checkpoint function in melanoma cell lines

H. Chu, J. Ibrahim, R. Paules, 2013, Cell cycle.

Dual inhibition of DNA-PK and DNA polymerase theta overcomes radiation resistance induced by p53 deficiency

G. Gupta, D. Ramsden, J. Purvis, 2020, NAR cancer.

Hyperactive end joining repair mediates resistance to DNA damaging therapy in p53-deficient cells

G. Gupta, J. Purvis, D. Simpson, 2020, bioRxiv.

Mechanisms of chromosomal instability in melanoma

B. Omolo, J. M. Shields, W. Kaufmann, 2014, Environmental and molecular mutagenesis.

A prognostic signature of defective p53‐dependent G1 checkpoint function in melanoma cell lines

H. Chu, C. Fan, J. Ibrahim, 2012, Pigment cell & melanoma research.

Defective cell cycle checkpoint functions in melanoma are associated with altered patterns of gene expression.

J. Ibrahim, N. Sharpless, J. M. Shields, 2008, The Journal of investigative dermatology.

Intracellular localization of the Fanconi anemia complementation group A protein.

D. Simpson, M. Yountz, C. Walsh, 1999, Biochemical and biophysical research communications.

SWI/SNF complexes are required for full activation of the DNA-damage response

D. Kaufman, W. Kaufmann, D. Simpson, 2015, Oncotarget.

Oncogenic BRAF(V600E) Induces Clastogenesis and UVB Hypersensitivity

W. Kaufmann, D. Simpson, S. Gaddameedhi, 2015, Cancers.

Assembly of viral membranes: maturation of the vesicular stomatitis virus glycoprotein in the presence of tunicamycin

D. Simpson, T. Morrison, C. McQuain, 1978, Journal of virology.

A predictive mathematical model of the DNA damage G2 checkpoint.

Timothy C Elston, Michael L Blinov, T. Elston, 2013, Journal of theoretical biology.

Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells

Matthew A Psioda, C. Perou, J. Ibrahim, 2017, npj Breast Cancer.

The Epstein-Barr Virus Immediate-Early Protein BZLF1 Induces both a G2 and a Mitotic Block

W. Kaufmann, S. Kenney, D. Simpson, 2002, Journal of Virology.

An Attenuating Mutation in nsP1 of the Sindbis-Group Virus S.A.AR86 Accelerates Nonstructural Protein Processing and Up-Regulates Viral 26S RNA Synthesis

R. Johnston, M. Heise, D. Simpson, 2003, Journal of Virology.