L. Hofseth

发表

A Limited Role of p53 on the Ability of a Hexane Fraction of American Ginseng to Suppress Mouse Colitis

M. Nagarkatti, P. Nagarkatti, Deepak Poudyal, 2012, Journal of biomedicine & biotechnology.

C. Harris, S. Hussain, L. Hofseth, 2004, Trends in pharmacological sciences.

Cancer‐associated molecular signature in the tissue samples of patients with cirrhosis

X. Wang, Yidong Chen, Q. Ye, 2004, Hepatology.

Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase.

C. Harris, S. Ambs, Anne B. Hofseth, 2009, Carcinogenesis.

Getting rigorous with scientific rigor

L. Hofseth, 2017, Carcinogenesis.

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

Varda Rotter, Curtis C. Harris, Ettore Appella, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation

M. Nagarkatti, P. Nagarkatti, L. Hofseth, 2017, PloS one.

Use of cannabinoids as a novel therapeutic modality against autoimmune hepatitis.

M. Nagarkatti, P. Nagarkatti, L. Hofseth, 2009, Vitamins and hormones.

Attenuation of Experimental Autoimmune Hepatitis by Exogenous and Endogenous Cannabinoids: Involvement of Regulatory T Cells

M. Nagarkatti, P. Nagarkatti, B. Cravatt, 2008, Molecular Pharmacology.

Resveratrol Suppresses Colitis and Colon Cancer Associated with Colitis

Edsel A. Peña, M. Nagarkatti, P. Nagarkatti, 2010, Cancer Prevention Research.

Estrogen and estrogen plus progestin act directly on the mammary gland to increase proliferation in a postmenopausal mouse model

S. Haslam, L. Hofseth, A. Raafat, 2001, Journal of cellular physiology.

The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 1999 by The Endocrine Society Hormone Replacement Therapy with Estrogen or Estrogen plus Medroxyprogesterone Acetate Is Associated with Increased Epithelial Proliferation

S. Haslam, C. Slomski, L. Hofseth, 2022 .

Dietary inflammatory index and odds of colorectal cancer in a case-control study from Jordan.

L. Hofseth, N. Shivappa, J. Hébert, 2017, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

Nitric oxide is a key component in inflammation-accelerated tumorigenesis.

Leah E. Mechanic, J. Weiss, C. Harris, 2008, Cancer research.

Radical causes of cancer

C. Harris, S. Hussain, L. Hofseth, 2003, Nature Reviews Cancer.

Increased p53 mutation load in nontumorous human liver of wilson disease and hemochromatosis: oxyradical overload diseases.

C. Harris, P. Galle, P. Shields, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung.

C. Harris, P. Shields, D. Phillips, 2001, Cancer research.

Hormone Replacement Therapy With Estrogen or Estrogen Plus Medroxyprogesterone Acetate Is Associated With Increased Epithelial Proliferation in the Normal Postmenopausal Breast

S. Haslam, C. Slomski, L. Hofseth, 2000 .

Panaxynol, a bioactive component of American ginseng, targets macrophages and suppresses colitis in mice

M. Nagarkatti, P. Nagarkatti, Deepak Poudyal, 2020, Oncotarget.

1 Panaxynol , a Bioactive Component of American 2 Ginseng , Targets Macrophages and Suppresses 3 Colitis in Mice 4

M. Nagarkatti, P. Nagarkatti, Deepak Poudyal, 2018 .

Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy.

B. Li, M. Nagarkatti, P. Nagarkatti, 2015, Journal of ethnopharmacology.

Acute and short-term administrations of delta-9-tetrahydrocannabinol modulate major gut metabolomic regulatory pathways in C57BL/6 mice

M. Nagarkatti, P. Nagarkatti, L. Hofseth, 2019, Scientific Reports.

Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor.

Deepak Poudyal, T. Davis, A. Chumanevich, 2011, American journal of physiology. Gastrointestinal and liver physiology.

Systemic inflammatory load in humans is suppressed by consumption of two formulations of dried, encapsulated juice concentrate.

P. Cavicchia, Xiangli Cui, Anne B. Hofseth, 2010, Molecular nutrition & food research.

American Ginseng Suppresses Colitis through p53-Mediated Apoptosis of Inflammatory Cells

M. Nagarkatti, P. Nagarkatti, Deepak Poudyal, 2010, Cancer Prevention Research.

Suppression of DNA damage in human peripheral blood lymphocytes by a juice concentrate: a randomized, double-blind, placebo-controlled trial.

P. Cavicchia, Deepak Poudyal, Xiangli Cui, 2012, Molecular Nutrition & Food Research.

D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy.

Xiangli Cui, A. Chumanevich, L. Hofseth, 2012, ACS medicinal chemistry letters.

Repurposing the anti-malarial drug, quinacrine: new anti-colitis properties

M. Nagarkatti, P. Nagarkatti, A. Chumanevich, 2016, Oncotarget.

Suppression of colitis-driven colon cancer in mice by a novel small molecule inhibitor of sphingosine kinase.

Deepak Poudyal, Xiangli Cui, T. Davis, 2010, Carcinogenesis.

American ginseng suppresses inflammation and DNA damage associated with mouse colitis

M. Nagarkatti, P. Nagarkatti, E. Peña, 2008, Carcinogenesis.

An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancer.

L. Hofseth, Lei Ying, 2007, Cancer research.

Resveratrol-Mediated Attenuation of Staphylococcus aureus Enterotoxin B-Induced Acute Liver Injury Is Associated With Regulation of microRNA and Induction of Myeloid-Derived Suppressor Cells

M. Nagarkatti, P. Nagarkatti, L. Hofseth, 2018, Front. Microbiol..

Inhibitory Effects of Nitric Oxide and Nitrosative Stress on Dopamine-β-Hydroxylase*

C. Harris, D. Wink, S. Hussain, 2000, The Journal of Biological Chemistry.

Nitric oxide is a signaling molecule that regulates gene expression.

C. Harris, A. Robles, L. Hofseth, 2005, Methods in enzymology.

Inhibiting Protein Arginine Deiminases Has Antioxidant Consequences

Xiangli Cui, Anne B. Hofseth, L. Hofseth, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Title Page Inhibiting protein arginine deiminases has anti-oxidant consequences.

Xiangli Cui, Anne B. Hofseth, L. Hofseth, 2015 .

Editorial: An apple a day keeps colitis away

L. Hofseth, L. Matesic, 2011, Journal of leukocyte biology.

Resveratrol (trans-3, 5, 4'-trihydroxystilbene) induces SIRT1 and down-regulates NF- κ B activation to abrogate DSS-induced colitis

R. Price, P. Nagarkatti, L. Hofseth, 2009 .

Themes Endocannabinoids and Liver Disease . III . Endocannabinoid effects on immune cells : implications for inflammatory liver diseases

Stephen P. H. Alexander, B. Cravatt, Adam D. Thomas, 2008 .

Taming the beast within: resveratrol suppresses colitis and prevents colon cancer

M. Nagarkatti, P. Nagarkatti, L. Hofseth, 2010, Aging.

Molecules from American Ginseng Suppress Colitis through Nuclear Factor Erythroid-2-Related Factor 2

M. Nagarkatti, P. Nagarkatti, A. Chumanevich, 2020, Nutrients.

An essential role of Nrf2 in American ginseng-mediated anti-oxidative actions in cardiomyocytes.

M. Nagarkatti, P. Nagarkatti, Yu Jin, 2010, Journal of ethnopharmacology.

Chronic Inflammation and Cancer An Emerging Role for Endothelial Nitric Oxide Synthase in Updated

L. Hofseth, Lei Ying, 2007 .

Role of resveratrol-induced CD11b+ Gr-1+ myeloid derived suppressor cells (MDSCs) in the reduction of CXCR3+ T cells and amelioration of chronic colitis in IL-10−/− mice

D. Taub, R. Price, M. Nagarkatti, 2012, Brain, Behavior, and Immunity.

Resveratrol (trans-3,5,4'-trihydroxystilbene) suppresses EL4 tumor growth by induction of apoptosis involving reciprocal regulation of SIRT1 and NF-κB.

M. Nagarkatti, P. Nagarkatti, L. Hofseth, 2011, Molecular nutrition & food research.

D ‑ Amino Acid-Based Protein Arginine Deiminase Inhibitors: Synthesis, Pharmacokinetics, and in Cellulo E ﬃ cacy

A. Chumanevich, L. Hofseth, P. Thompson, 2012 .

Seeing citrulline: development of a phenylglyoxal-based probe to visualize protein citrullination.

A. Chumanevich, L. Hofseth, P. Thompson, 2012, Journal of the American Chemical Society.

Nitric Oxide, a Mediator of Inflammation, Suppresses Tumorigenesis

Leah E. Mechanic, C. Harris, S. Hussain, 2004, Cancer Research.

Nitric oxide as a target of complementary and alternative medicines to prevent and treat inflammation and cancer.

L. Hofseth, 2008, Cancer letters.

Pharmacokinetics of Panaxynol in Mice

M. Nagarkatti, P. Nagarkatti, A. Chumanevich, 2020, Journal of cancer science and clinical therapeutics.

Inflammation, cancer, and targets of ginseng.

M. Wargovich, L. Hofseth, 2007, The Journal of nutrition.

Mechanistic insight into the ability of American ginseng to suppress colon cancer associated with colitis.

Edsel A. Peña, M. Nagarkatti, P. Nagarkatti, 2010, Carcinogenesis.

American ginseng preferentially suppresses STAT/iNOS signaling in activated macrophages.

M. Nagarkatti, P. Nagarkatti, A. Windust, 2009, Journal of ethnopharmacology.

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Gloria S. Huang, Rob J. Kulathinal, C. Smythe, 2015, Seminars in cancer biology.

A multi-targeted approach to suppress tumor-promoting inflammation.

A. Azmi, L. Ricciardiello, A. Bishayee, 2015, Seminars in cancer biology.

TP53 and liver carcinogenesis

X. Wang, C. Harris, F. Staib, 2003, Human mutation.

Molecular pathogenesis of human hepatocellular carcinoma.

X. Wang, C. Harris, M. Forgues, 2002, Toxicology.

The Induction of microRNA-16 in Colon Cancer Cells by Protein Arginine Deiminase Inhibition Causes a p53-Dependent Cell Cycle Arrest

A. Schetter, C. Harris, Deepak Poudyal, 2013, PloS one.

A novel chemopreventive strategy based on therapeutic microRNAs produced in plants

L. Hofseth, S. Mlotshwa, Vicki Vance, 2015, Cell Research.

Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer

Paul R. Thompson, Xiangli Cui, L. Hofseth, 2015, Oncotarget.

Gastrointestinal Hyperplasia with Altered Expression of DNA Polymerase β

Samuel H. Wilson, A. Sepulveda, Xiangli Cui, 2009, PloS one.

p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

Leah E. Mechanic, C. Harris, A. Robles, 2004, Cancer Research.

The adaptive imbalance in base excision-repair enzymes generates microsatellite instability in chronic inflammation.

Leah E. Mechanic, V. Rotter, C. Harris, 2003, The Journal of clinical investigation.

Macrophages, Nitric Oxide and microRNAs Are Associated with DNA Damage Response Pathway and Senescence in Inflammatory Bowel Disease

Jane J. Sohn, A. Schetter, E. Bowman, 2012, PloS one.

Chronic inflammation promotes retinoblastoma protein hyperphosphorylation and E2F1 activation.

C. Harris, Mohammed A. Khan, D. Dixon, 2005, Cancer research.

Inflammation and IGF‐I activate the Akt pathway in breast cancer

S. Ambs, D. Wink, R. Prueitt, 2007, International journal of cancer.

p53: at the crossroads of molecular carcinogenesis and molecular epidemiology.

X. Wang, C. Harris, A. Robles, 2004, Chest.

Ginkgo biloba extract EGb 761 has anti-inflammatory properties and ameliorates colitis in mice by driving effector T cell apoptosis.

R. Price, M. Nagarkatti, P. Nagarkatti, 2008, Carcinogenesis.

Rejoining of DNA double-strand breaks after the introduction of chromosome 11 into a radiosensitive bladder carcinoma cell line.

L. Hofseth, M. Rosin, S. Tsang, 1997, Mutation research.

Inducible Nitric Oxide Synthase as a Target for Chemoprevention

C. Harris, S. Hussain, L. Hofseth, 2004 .

Nitric oxide in cancer and chemoprevention.

C. Harris, S. Hussain, L. Hofseth, 2003, Free radical biology & medicine.

Tumor suppressor genes: at the crossroads of molecular carcinogenesis, molecular epidemiology and human risk assessment.

S. Hussain, C. C. Harris, L. Hofseth, 2001, Lung cancer.

Citrullination in Inflammatory-Driven Carcinogenesis of the Colon

L. Hofseth, Erin E. Witalison, 2017 .

Identifying and defusing weapons of mass inflammation in carcinogenesis.

L. Hofseth, Lei Ying, Lorne J Hofseth, 2006, Biochimica et biophysica acta.

Colorectal cancer disparities in South Carolina: descriptive epidemiology, screening, special programs, and future direction.

M. Horner, M. Wargovich, L. Hofseth, 2006, Journal of the South Carolina Medical Association.

The adaptive imbalance to genotoxic stress: genome guardians rear their ugly heads.

L. Hofseth, 2004, Carcinogenesis.

A Key Role of microRNA-29b for the Suppression of Colon Cancer Cell Migration by American Ginseng

A. Schetter, C. Harris, M. Nagarkatti, 2013, PloS one.

The p53 tumor suppressor network is a key responder to microenvironmental components of chronic inflammatory stress.

John N Weinstein, Frank Staib, X. Wang, 2005, Cancer research.

Maternal stress and early-onset colorectal cancer.

L. Hofseth, F. Berger, B. Love, 2018, Medical hypotheses.

Micronucleus frequencies in urothelial cells of catheterized patients with chronic bladder inflammation.

L. Hofseth, M. Rosin, B. Dunn, 1996, Mutation research.

Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53.

C. Harris, A. Robles, L. Hofseth, 2004, Cancer research.

Early-onset colorectal cancer: initial clues and current views

P. Buckhaults, L. Hofseth, J. Hébert, 2020, Nature Reviews Gastroenterology & Hepatology.

Printed in U.S.A. Copyright © 1999 by The Endocrine Society A Mouse Model to Study the Effects of Hormone Replacement Therapy on Normal Mammary Gland during Menopause: Enhanced Proliferative Response to Estrogen in Late Postmenopausal Mice*

S. Haslam, L. Hofseth, A. Raafat, 2022 .

Hypoxic inducible factor 1α, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide

C. Harris, D. Wink, L. Hofseth, 2004, Proceedings of the National Academy of Sciences of the United States of America.

The Dietary Inflammatory Index is associated with elevated white blood cell counts in the National Health and Nutrition Examination Survey

L. Hofseth, N. Shivappa, J. Hébert, 2017, Brain, Behavior, and Immunity.

Postmenopausal Hormone Replacement Therapy: Effects on Normal Mammary Gland in Humans and in a Mouse Postmenopausal Model

S. Haslam, L. Hofseth, J. Osuch, 2004, Journal of Mammary Gland Biology and Neoplasia.

The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors.

Yuan Luo, A. Chumanevich, L. Hofseth, 2011, Journal of medicinal chemistry.

p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination.

X. Wang, C. Harris, S. Linke, 2003, Cancer research.

Resveratrol (trans-3,5,4′-Trihydroxystilbene) Ameliorates Experimental Allergic Encephalomyelitis, Primarily via Induction of Apoptosis in T Cells Involving Activation of Aryl Hydrocarbon Receptor and Estrogen Receptor

M. Nagarkatti, P. Nagarkatti, L. Hofseth, 2007, Molecular Pharmacology.

Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation.

Paul R Thompson, L. Hofseth, P. Thompson, 2015, Current drug targets.

Circadian Disruption, Per3, and Human Cytokine Secretion

Sara E. Wagner, L. Hofseth, J. Hébert, 2009, Integrative cancer therapies.

Nutraceuticals and Colon Cancer Prevention

Deepak Poudyal, L. Hofseth, 2014 .

Interacts with hRAD 51 and hRAD 54 , and Directly Modulates Homologous Recombination 1 , 2

X. Wang, C. Harris, S. Linke, 2003 .

Inflammation,Cancer,andTargetsofGinseng 1-3

M. Wargovich, L. Hofseth, 2007 .

Inflammation , Cancer , and Targetsof Ginseng 1 – 3

M. Wargovich, L. Hofseth, 2006 .

Looking for the best anti-colitis medicine: A comparative analysis of current and prospective compounds

M. Nagarkatti, P. Nagarkatti, E. Peña, 2016, Oncotarget.

Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation

C. Harris, H. Clevers, M. Karin, 2012, Proceedings of the National Academy of Sciences.

The role of p53 in base excision repair following genotoxic stress.

V. Rotter, C. Harris, S. Hussain, 2003, Carcinogenesis.

The Dietary Inflammatory Index Is Associated with Colorectal Cancer Risk in the Multiethnic Cohort.

C. Haiman, L. Le Marchand, L. Wilkens, 2017, The Journal of nutrition.

Nitric oxide and p53 in cancer‐prone chronic inflammation and oxyradical overload disease

S. Hussain, L. Hofseth, J. Goodman, 2004, Environmental and molecular mutagenesis.

Resveratrol (Trans-3,5,4′-trihydroxystilbene) Induces Silent Mating Type Information Regulation-1 and Down-Regulates Nuclear Transcription Factor-κB Activation to Abrogate Dextran Sulfate Sodium-Induced Colitis

R. Price, M. Nagarkatti, P. Nagarkatti, 2010, Journal of Pharmacology and Experimental Therapeutics.

A Hexane Fraction of American Ginseng Suppresses Mouse Colitis and Associated Colon Cancer: Anti-inflammatory and Proapoptotic Mechanisms

M. Nagarkatti, P. Nagarkatti, Deepak Poudyal, 2012, Cancer Prevention Research.

Proliferative effects of combination estrogen and progesterone replacement therapy on the normal postmenopausal mammary gland in a murine model.

S. Haslam, L. Hofseth, A. Raafat, 2001, American journal of obstetrics and gynecology.

Nitric oxide inactivates the retinoblastoma pathway in chronic inflammation.

M. Nagarkatti, P. Nagarkatti, Anne B. Hofseth, 2007, Cancer research.

Acute and short-term administrations of delta-9-tetrahydrocannabinol modulate major gut metabolomic regulatory pathways in C57BL/6 mice

M. Nagarkatti, P. Nagarkatti, L. Hofseth, 2019, Scientific Reports.

Hexane Fraction of American Ginseng Suppresses Colitis and Colon Cancer—Response

M. Nagarkatti, P. Nagarkatti, Deepak Poudyal, 2012, Cancer Prevention Research.

The synthetic food dye, Red 40, causes DNA damage, causes colonic inflammation, and impacts the microbiome in mice

Qi Zhang, A. Chumanevich, L. Hofseth, 2023, Toxicology reports.