S. Dertinger

发表

Sublethal radiation injury uncovers a functional transition during erythroid maturation.

Yuhchyau Chen, S. A. Peslak, J. Wenger, 2011, Experimental hematology.

Kinetics of γH2AX and phospho-histone H3 following pulse treatment of TK6 cells provides insights into clastogenic activity.

J. Bemis, S. Dertinger, Steven M. Bryce, 2021, Mutagenesis.

In vivo erythrocyte micronucleus assay III. Validation and regulatory acceptance of automated scoring and the use of rat peripheral blood reticulocytes, with discussion of non-hematopoietic target cells and a single dose-level limit test.

Stephen D Dertinger, Makoto Hayashi, Norihide Asano, 2007, Mutation research.

Response kinetics of radiation-induced micronucleated reticulocytes in human bone marrow culture.

Yuhchyau Chen, S. Dertinger, Y. Tsai, 2011, Mutation research.

Gamma-radiation induces micronucleated reticulocytes in 3D bone marrow bioreactors in vitro.

O. Hyrien, Yuhchyau Chen, S. Dertinger, 2009, Mutation research.

Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements.

S. Dertinger, T. Gasiewicz, C. Palermo, 2003, Molecular pharmacology.

Simple and reliable enumeration of micronucleated reticulocytes with a single-laser flow cytometer.

S. Dertinger, D. Torous, D. Torous, 1996, Mutation research.

Flow cytometric analysis of micronuclei in peripheral blood reticulocytes III. An efficient method of monitoring chromosomal damage in the beagle dog.

J. T. Macgregor, S. Dertinger, M. Bishop, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

Comparison of male versus female responses in the Pig-a mutation assay.

J. T. Macgregor, J. Bemis, S. Dertinger, 2015, Mutagenesis.

In vitro human cell‐based aneugen molecular mechanism assay

J. Bemis, S. Dertinger, Steven M. Bryce, 2022, Environmental and molecular mutagenesis.

AOP report: Development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations

C. Yauk, G. Hendriks, S. Dertinger, 2022, Environmental and molecular mutagenesis.

Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice

Dushan N. Wadduwage, L. Samson, F. White, 2021, bioRxiv.

Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice

Dushan N. Wadduwage, L. Samson, F. White, 2020, bioRxiv.

Flow cytometric analysis of Pig‐a gene mutation and chromosomal damage induced by procarbazine hydrochloride in CD‐1 mice

J. T. Macgregor, J. Bemis, S. Dertinger, 2013, Environmental and molecular mutagenesis.

Integrated In Vivo Genotoxicity Assessment of Procarbazine Hydrochloride Demonstrates Induction of Pig‐a and LacZ Mutations, and Micronuclei, in MutaMouse Hematopoietic Cells

C. Yauk, S. Dertinger, F. Marchetti, 2019, Environmental and molecular mutagenesis.

Persistence of cisplatin-induced mutagenicity in hematopoietic stem cells: implications for secondary cancer risk following chemotherapy.

J. T. Macgregor, J. Bemis, S. Dertinger, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Diet‐induced obesity increases the frequency of Pig‐a mutant erythrocytes in male C57BL/6J mice

S. Dertinger, D. Torous, Mark Wilson, 2016, Environmental and molecular mutagenesis.

In vivo delivery of FTY720 prevents radiation-induced ovarian failure and infertility in adult female nonhuman primates.

S. Dertinger, J. Tilly, R. Casper, 2011, Fertility and sterility.

Part 2. Assessment of micronucleus formation in rats after chronic exposure to new-technology diesel exhaust in the ACES bioassay.

J. Bemis, S. Dertinger, D. Torous, 2015, Research report.

Comparison of in vitro and in vivo clastogenic potency based on benchmark dose analysis of flow cytometric micronucleus data.

J. Bemis, S. Dertinger, W. Slob, 2016, Mutagenesis.

In vivo antagonism of AhR-mediated gene induction by 3'-methoxy-4'-nitroflavone in TCDD-responsive lacZ mice.

S. Dertinger, T. Gasiewicz, D. Nazarenko, 2001, Toxicological sciences : an official journal of the Society of Toxicology.

Benchmark Dose Analysis of DNA Damage Biomarker Responses Provides Compound Potency and Adverse Outcome Pathway Information for the Topoisomerase II Inhibitor Class of Compounds

Ryan P Wheeldon, G. Johnson, J. Bemis, 2020, Environmental and molecular mutagenesis.

Micronucleated CD71-positive reticulocytes: a blood-based endpoint of cytogenetic damage in humans.

Yuhchyau Chen, S. Dertinger, D. Torous, 2003, Mutation research.

In vitro micronucleus assay –increase in binucleated cells in mononucleate assay

S. Dertinger, M. Cooke, A. Lynch, 2010 .

Genotoxic effects of two-generational selenium deficiency in mouse somatic and testicular cells.

C. Instanes, G. Brunborg, B. Salbu, 2015, Mutagenesis.

Influence of aromatic hydrocarbon receptor-mediated events on the genotoxicity of cigarette smoke condensate.

S. Dertinger, T. Gasiewicz, A. Silverstone, 1998, Carcinogenesis.

Black cohosh extracts and powders induce micronuclei, a biomarker of genetic damage, in human cells

S. Smith‐Roe, S. Auerbach, K. Witt, 2018, Environmental and molecular mutagenesis.

Part 2. Assessment of genotoxicity after exposure to diesel exhaust from U.S. 2007-compliant diesel engines: report on 1- and 3-month exposures in the ACES bioassay.

J. Bemis, S. Dertinger, D. Torous, 2012, Research report.

Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: I. Intra- and interlaboratory comparison with microscopic scoring.

J. T. Macgregor, Takayoshi Suzuki, M. Moore, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Interlaboratory validation of a CD71‐based flow cytometric method (Microflow®) for the scoring of micronucleated reticulocytes in mouse peripheral blood

P. Harbach, K. Sandelin, L. Ferguson, 2005, Environmental and molecular mutagenesis.

Three‐color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood

K. Camphausen, C. Ménard, J. T. Macgregor, 2004, Environmental and molecular mutagenesis.

Flow cytometric enumeration of micronucleated reticulocytes: High transferability among 14 laboratories

M. Fenech, P. Harbach, K. Sandelin, 2001, Environmental and molecular mutagenesis.

Analysis of historical negative control group data from the rat in vivo micronucleus assay.

S. Dertinger, M. Fellows, D. Lovell, 2020, Mutation research.

In vivo flow cytometric Pig‐a and micronucleus assays: Highly sensitive discrimination of the carcinogen/noncarcinogen pair benzo(a)pyrene and pyrene using acute and repeated‐dose designs

J. T. Macgregor, J. Bemis, S. Dertinger, 2012, Environmental and molecular mutagenesis.

Modulation of phorbol ester-induced HL-60 differentiation by prostaglandin E2.

S. Dertinger, D. Torous, A. Tometsko, 1995, Mutation research.

Assessment of systemic genetic damage in pediatric inflammatory bowel disease

J. T. Macgregor, J. Bemis, S. Dertinger, 2020, Environmental and molecular mutagenesis.

Single cell gel electrophoresis (SCGE) and Pig-a mutation assay in vivo-tools for genotoxicity testing from a regulatory perspective: a study of benzo[a]pyrene in Ogg1(-/-) mice.

C. Instanes, B. Lindeman, G. Brunborg, 2014, Mutation research. Genetic toxicology and environmental mutagenesis.

Compensatory erythropoiesis has no impact on the outcome of the in vivo Pig-a mutation assay in rats following treatment with the haemolytic agent 2-butoxyethanol.

S. Dertinger, M. Kenyon, J. Ackerman, 2015, Mutagenesis.

Erythrocyte-Based Pig-a Gene Mutation Assay.

J. Bemis, S. Dertinger, N. Hall, 2019, Methods in molecular biology.

Building on the past, shaping the future: The environmental mutagenesis and genomics society

P. Hanawalt, S. Smith‐Roe, J. T. Macgregor, 2013, Environmental and molecular mutagenesis.

High content flow cytometric micronucleus scoring method is applicable to attachment cell lines

J. Bemis, S. Dertinger, Steven M. Bryce, 2009, Environmental and molecular mutagenesis.

Rat Pig-a mutation assay responds to the genotoxic carcinogen ethyl carbamate but not the non-genotoxic carcinogen methyl carbamate.

J. T. Macgregor, J. Bemis, S. Dertinger, 2015, Mutagenesis.

Analysis of micronucleated cells by flow cytometry. 4. Kinetic analysis of cytogenetic damage in blood.

S. Dertinger, D. Torous, A. Tometsko, 1995, Mutation research.

Analysis of micronucleated cells by flow cytometry. 3. Advanced technology for detecting clastogenic activity.

S. Dertinger, D. Torous, A. Tometsko, 1993, Mutation research.

3Rs friendly study designs facilitate rat liver and blood micronucleus assays and Pig‐a gene mutation assessments: Proof‐of‐concept with 13 reference chemicals

J. T. Macgregor, J. Bemis, S. Dertinger, 2019, Environmental and molecular mutagenesis.

Investigating the Generalizability of the MultiFlow ® DNA Damage Assay and Several Companion Machine Learning Models With a Set of 103 Diverse Test Chemicals

Stephen D Dertinger, Kristine L Witt, Stephanie L Smith-Roe, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Mouse Pig‐a and micronucleus assays respond to N‐ethyl‐N‐nitrosourea, benzo[a]pyrene, and ethyl carbamate, but not pyrene or methyl carbamate

J. T. Macgregor, J. Bemis, S. Dertinger, 2016, Environmental and molecular mutagenesis.

Pig‐a gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3‐propane sultone

J. T. Macgregor, J. Bemis, S. Dertinger, 2014, Environmental and molecular mutagenesis.

Efficient monitoring of in vivo pig-a gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds.

J. T. Macgregor, J. Bemis, S. Dertinger, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Elevated frequencies of micronucleated erythrocytes in infants exposed to zidovudine in utero and postpartum to prevent mother‐to‐child transmission of HIV

K. Witt, S. Dertinger, G. Kissling, 2007, Environmental and molecular mutagenesis.

Flow cytometric analysis of micronuclei in peripheral blood reticulocytes: II. An efficient method of monitoring chromosomal damage in the rat.

Junichiro Saito, Stephen D Dertinger, Makoto Hayashi, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Effect of 3'-methoxy-4'-nitroflavone on benzo[a]pyrene toxicity. Aryl hydrocarbon receptor-dependent and -independent mechanisms.

S. Dertinger, T. Gasiewicz, A. Silverstone, 2000, Biochemical pharmacology.

In vivo rodent erythrocyte micronucleus assay. II. Some aspects of protocol design including repeated treatments, integration with toxicity testing, and automated scoring

J. T. Macgregor, S. Dertinger, T. Morita, 2000, Environmental and molecular mutagenesis.

Induction of micronuclei by low doses of azidothymidine (AZT).

S. Dertinger, D. Torous, K. R. Tometsko, 1996, Mutation research.

Cross‐Species Genetic Toxicity Assessment Accomplished by Flow Cytometric Analysis of Blood

J. Bemis, S. Dertinger, D. Torous, 2008, Current protocols in toxicology.

Interpreting in vitro micronucleus positive results: Simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents

J. Bemis, S. Dertinger, Steven M. Bryce, 2014, Environmental and molecular mutagenesis.

In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity.

Stephen D Dertinger, Steven M Bryce, Jeffrey C Bemis, 2007, Mutation research.

A proposal for a novel rationale for critical effect size in dose-response analysis based on a multi-endpoint in vivo study with methyl methanesulfonate.

Andreas Zeller, Stephen D Dertinger, Leilei Tang, 2016, Mutagenesis.

The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup.

K. Witt, P. White, S. Dertinger, 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

Assessment of the genotoxic potential of azidothymidine in the comet, micronucleus, and Pig-a assay.

T. Singer, S. Dertinger, M. Festag, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

New and emerging technologies for genetic toxicity testing

Jiri Aubrecht, Robert H Schiestl, James F Rusling, 2011, Environmental and molecular mutagenesis.

The Pig-a Gene Mutation Assay in Mice and Human Cells: A Review.

C. Instanes, G. Brunborg, A. Hartwig, 2017, Basic & clinical pharmacology & toxicology.

Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: effect of age.

O. Hyrien, Yuhchyau Chen, J. Bemis, 2009, Mutation research.

Gamma radiation at a human relevant low dose rate is genotoxic in mice

C. Instanes, G. Brunborg, D. Oughton, 2016, Scientific Reports.

When pigs fly: immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis.

S. Dertinger, Steven M. Bryce, Svetlana L. Avlasevich, 2011, Mutation research.

The in vivo pig‐a gene mutation assay, a potential tool for regulatory safety assessment

S. Dertinger, R. Heflich, V. Dobrovolsky, 2010, Environmental and molecular mutagenesis.

Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential.

J. Bemis, S. Dertinger, Steven M. Bryce, 2008, Mutation research.

Identification of potential aryl hydrocarbon receptor antagonists in green tea.

S. Dertinger, T. Gasiewicz, A. Kende, 2003, Chemical research in toxicology.

Flow cytometric scoring of micronucleated erythrocytes: an efficient platform for assessing in vivo cytogenetic damage.

Stephen D Dertinger, Makoto Hayashi, J. T. Macgregor, 2011, Mutagenesis.

Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities-Report from an ECVAM workshop.

Raffaella Corvi, Peter Kasper, Cyrille Krul, 2009, Mutation research.

Practical threshold for micronucleated reticulocyte induction observed for low doses of mitomycin C, Ara-C and colchicine.

S. Dertinger, M. Hayashi, T. Morita, 2006, Mutagenesis.

Performance of flow cytometric analysis for the micronucleus assay--a reconstruction model using serial dilutions of malaria-infected cells with normal mouse peripheral blood.

S. Dertinger, M. Hayashi, T. Morita, 2006, Mutagenesis.

Flow cytometric analysis of micronuclei in mammalian cell cultures: past, present and future.

John Nicolette, Anthony Lynch, Freddy Van Goethem, 2011, Mutagenesis.

Automated human blood micronucleated reticulocyte measurements for rapid assessment of chromosomal damage.

Yuhchyau Chen, S. Dertinger, Steven M. Bryce, 2007, Mutation research.

Quantitative analysis of Howell-Jolly bodies in children with sickle cell disease.

S. Dertinger, R. Ware, T. Howard, 2004, Experimental hematology.

High information content assays for genetic toxicology testing: A report of the International Workshops on Genotoxicity Testing (IWGT).

Paul A. White, Carole L. Yauk, Jos C. S. Kleinjans, 2019, Mutation research.

Assessment of genotoxicity associated with hydroxyurea therapy in children with sickle cell anemia.

S. Dertinger, R. Ware, M. Smeltzer, 2009, Mutation research.

Enumeration of micronucleated reticulocytes in rat peripheral blood: a flow cytometric study.

S. Dertinger, D. Torous, D K Torous, 2000, Mutation research.

Malaria-infected erythrocytes serve as biological standards to ensure reliable and consistent scoring of micronucleated erythrocytes by flow cytometry.

S. Dertinger, T. Gasiewicz, D. Torous, 2000, Mutation research.

Analysis of micronucleated cells by flow cytometry. 1. Achieving high resolution with a malaria model.

S. Dertinger, D. Torous, A. Tometsko, 1993, Mutation research.

Aneugen Molecular Mechanism Assay: Proof of Concept with 27 Reference Chemicals.

J. Bemis, S. Dertinger, Steven M. Bryce, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Lack of DNA Polymerase θ (POLQ) Radiosensitizes Bone Marrow Stromal Cells In Vitro and Increases Reticulocyte Micronuclei after Total-Body Irradiation

Hong Wang, R. Wood, S. Dertinger, 2009, Radiation research.

Flow cytometric analysis of micronuclei in peripheral blood reticulocytes IV: an index of chromosomal damage in the rhesus monkey (Macaca mulatta).

W. Slikker, J. T. Macgregor, M. Moore, 2008, Toxicological sciences : an official journal of the Society of Toxicology.

Enumeration of micronucleated CD71-positive human reticulocytes with a single-laser flow cytometer.

S. Dertinger, D. Torous, Richard K. Miller, 2002, Mutation research.

Reticulocyte and micronucleated reticulocyte responses to gamma irradiation: dose-response and time-course profiles measured by flow cytometry.

O. Hyrien, Yuhchyau Chen, J. Bemis, 2007, Mutation research.

Human erythrocyte PIG‐A assay: An easily monitored index of gene mutation requiring low volume blood samples

J. T. Macgregor, Yuhchyau Chen, J. Bemis, 2015, Environmental and molecular mutagenesis.

Pig-a mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens.

Ollivier Hyrien, Stephen D Dertinger, James Palis, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Inter-laboratory validation of the in-vivo flow cytometric micronucleus analysis method (MicroFlow®) in China.

S. Dertinger, Zhaomin Zhong, Yang Luan, 2014, Mutation research. Genetic toxicology and environmental mutagenesis.

Cyclophosphamide and etoposide canine studies demonstrate the cross-species potential of the flow cytometric peripheral blood micronucleated reticulocyte endpoint.

S. Dertinger, D. Kirkland, G. Schmuck, 2012, Mutation research.

Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies.

J. T. Macgregor, O. Hyrien, J. Bemis, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

VALIDATING HIGH-THROUGHPUT MICRONUCLEUS ANALYSIS OF PERIPHERAL RETICULOCYTES FOR RADIATION BIODOSIMETRY: BENCHMARK AGAINST DICENTRIC AND CBMN ASSAYS IN A MOUSE MODEL

Irena Nowak, Stephen D Dertinger, Hongliang Sun, 2010, Health physics.

Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy.

Stephen D Dertinger, S. Dertinger, D. Torous, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Sensitivity of the erythrocyte micronucleus assay: dependence on number of cells scored and inter-animal variability.

J. T. Macgregor, S. Dertinger, M. Hayashi, 2007, Mutation research.

In vivo genotoxicity testing strategies: Report from the 7th International workshop on genotoxicity testing (IWGT).

N. Mei, Andrew Williams, S. Dertinger, 2019, Mutation research.

Simultaneous Measurement of Benzo[a]pyrene-induced Pig-a and lacZ Mutations, Micronuclei and DNA Adducts in Muta™ Mouse

P. White, V. Arlt, D. Phillips, 2011, Environmental and molecular mutagenesis.

Interlaboratory evaluation of a flow cytometric, high content in vitro micronucleus assay.

Stephen D Dertinger, Jacky Van Gompel, Freddy Van Goethem, 2008, Mutation research.

In vitro micronucleus scoring by flow cytometry: Differential staining of micronuclei versus apoptotic and necrotic chromatin enhances assay reliability

Stephen D Dertinger, Steven M Bryce, S. Dertinger, 2006, Environmental and molecular mutagenesis.

In vivo mutation assay based on the endogenous Pig‐a locus

J. Bemis, S. Dertinger, Steven M. Bryce, 2008, Environmental and molecular mutagenesis.

Integration of liver and blood micronucleus and Pig-a gene mutation endpoints into rat 28-day repeat-treatment studies: Proof-of-principle with diethylnitrosamine.

J. Bemis, S. Dertinger, D. Torous, 2018, Mutation research. Genetic toxicology and environmental mutagenesis.

New and Emerging Genetic Toxicity Tests and Approaches to Genetic Toxicology Testing

S. Dertinger, R. Heflich, P. Escobar, 2015 .

Flow cytometric method for scoring rat liver micronuclei with simultaneous assessments of hepatocyte proliferation

J. Bemis, S. Dertinger, D. Torous, 2018, Environmental and molecular mutagenesis.

Diethylnitrosamine genotoxicity evaluated in sprague dawley rats using Pig‐a mutation and reticulocyte micronucleus assays

J. T. Macgregor, J. Bemis, S. Dertinger, 2014, Environmental and molecular mutagenesis.

International Pig‐a gene mutation assay trial: Evaluation of transferability across 14 laboratories

J. T. Macgregor, A. Elhajouji, Kentaro Tanaka, 2011, Environmental and molecular mutagenesis.

Dextran sulfate sodium mouse model of inflammatory bowel disease evaluated for systemic genotoxicity via blood micronucleus and Pig-a gene mutation assays.

J. Bemis, S. Dertinger, L. Saubermann, 2020, Mutagenesis.

Continued progress in developing the Pig-a gene mutation assay.

S. Dertinger, R. Heflich, V. Dobrovolsky, 2015, Mutagenesis.

A statistical approach for analyzing data from the in vivo Pig-a gene mutation assay.

A. Sutter, S. Dertinger, M. Raschke, 2018, Mutation research. Genetic toxicology and environmental mutagenesis.

In vivo pig‐a and micronucleus study of the prototypical aneugen vinblastine sulfate

J. T. Macgregor, J. Bemis, S. Dertinger, 2018, Environmental and molecular mutagenesis.

Interlaboratory Pig‐a gene mutation assay trial: Studies of 1,3‐propane sultone with immunomagnetic enrichment of mutant erythrocytes

J. T. Macgregor, J. Bemis, S. Dertinger, 2011, Environmental and molecular mutagenesis.

Induction of in vivo Pig-a gene mutation but not micronuclei by 5-(2-chloroethyl)-2’-deoxyuridine, an antiviral pyrimidine nucleoside analogue

A. Elhajouji, S. Dertinger, R. Downing, 2018, Mutagenesis.

In Vivo Pig‐a gene mutation assay: Guidance for 3Rs‐friendly implementation

A. Sutter, S. Dertinger, J. Bhalli, 2016, Environmental and molecular mutagenesis.

Induction of Pig-a mutant erythrocytes in male and female rats exposed to 1,3-propane sultone, ethyl carbamate, or thiotepa.

J. T. Macgregor, J. Bemis, S. Dertinger, 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

Assessment of 5‐fluorouracil and 4‐nitroquinoline‐1‐oxide in vivo genotoxicity with Pig‐a mutation and micronucleus endpoints

S. Dertinger, D. Torous, Honggang Tu, 2014, Environmental and molecular mutagenesis.

In vivo assessment of Pig‐a gene mutation—recent developments and assay validation

S. Dertinger, R. Heflich, 2011, Environmental and molecular mutagenesis.

Suitability of Long‐Term Frozen Rat Blood Samples for the Interrogation of Pig‐a Gene Mutation by Flow Cytometry

J. Bemis, S. Dertinger, J. Bhalli, 2018, Environmental and molecular mutagenesis.

Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms

Kyungho Choi, Tetsushi Sakuma, Jun Nakamura, 2018, Environmental and molecular mutagenesis.

Predictions of genotoxic potential, mode of action, molecular targets, and potency via a tiered multiflow® assay data analysis strategy

Stephen D Dertinger, George E Johnson, Patricia A Escobar, 2019, Environmental and molecular mutagenesis.

Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay

A. Sutter, E. Lorge, J. Bemis, 2017, Environmental and molecular mutagenesis.

The use of benchmark dose uncertainty measurements for robust comparative potency analyses

Ryan P Wheeldon, G. Johnson, J. Bemis, 2021, Environmental and molecular mutagenesis.

γH2AX and p53 responses in TK6 cells discriminate promutagens and nongenotoxicants in the presence of rat liver S9

J. Bemis, S. Dertinger, D. Kirkland, 2016, Environmental and molecular mutagenesis.

Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach

J. Bemis, S. Dertinger, Steven M. Bryce, 2016, Environmental and molecular mutagenesis.

Benchmark dose analyses of multiple genetic toxicity endpoints permit robust, cross-tissue comparisons of MutaMouse responses to orally delivered benzo[a]pyrene

P. White, V. Arlt, S. Dertinger, 2017, Archives of Toxicology.

Empirical analysis of BMD metrics in genetic toxicology part II: in vivo potency comparisons to promote reductions in the use of experimental animals for genetic toxicity assessment.

P. White, G. Johnson, J. Bemis, 2016, Mutagenesis.

3Rs‐friendly approach to exogenous metabolic activation that supports high‐throughput genetic toxicology testing

J. Bemis, S. Dertinger, Steven M. Bryce, 2020, Environmental and molecular mutagenesis.

Flow cytometric 96‐well microplate‐based in vitro micronucleus assay with human TK6 cells: Protocol optimization and transferability assessment

R. Walmsley, A. Elhajouji, J. Bemis, 2013, Environmental and molecular mutagenesis.

In vitro system for detecting nongenotoxic carcinogens

S. Dertinger, D. Torous, A. Tometsko, 1993, Environmental and molecular mutagenesis.

Miniaturized flow cytometry‐based CHO‐K1 micronucleus assay discriminates aneugenic and clastogenic modes of action

J. Bemis, S. Dertinger, Steven M. Bryce, 2011, Environmental and molecular mutagenesis.

An automated method for discriminating aneugen‐ vs. clastogen‐induced micronuclei

S. Dertinger, D. Torous, D K Torous, 1998, Environmental and molecular mutagenesis.

Analysis of micronucleated cells by flow cytometry. 2. Evaluating the accuracy of high-speed scoring.

S. Dertinger, D. Torous, A. Tometsko, 1993, Mutation research.

Dose–response relationship of temozolomide, determined by the Pig-a, comet, and micronucleus assay

S. Dertinger, J. Funk, M. Guérard, 2016, Archives of Toxicology.

Flow cytometric analysis of micronucleated reticulocytes in mouse bone marrow.

S. Dertinger, D. Torous, K. R. Tometsko, 1997, Mutation research.

P-118 / O-14 Cyclophosphamide and Etoposide Canine Studies Demonstrate the Cross-Species Potential of the Peripheral Blood Micronucleated Reticulocyte Endpoint(Poster Session)

S. Dertinger, D. Kirkland, G. Schmuck, 2008 .

Influence of counting methodology on erythrocyte ratios in the mouse micronucleus test

M. LeBaron, S. Dertinger, B. Gollapudi, 2013, Environmental and molecular mutagenesis.

Flavone antagonists bind competitively with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to the aryl hydrocarbon receptor but inhibit nuclear uptake and transformation.

S. Dertinger, R. Pollenz, J. Jones, 1999, Molecular pharmacology.

Pig-a gene mutation assay study design: critical assessment of 3- versus 28-day repeat-dose treatment schedules.

A. Elhajouji, S. Dertinger, H. Martus, 2020, Mutagenesis.

Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose

Marc A. Beal, G. Hendriks, G. Johnson, 2022, Environmental and molecular mutagenesis.

Development of a sensitive in vitro method for identifying tumor promoters.

S. Dertinger, D. Torous, A. Tometsko, 1995, Mutation research.

Human blood PIG‐A mutation and micronucleated reticulocyte flow cytometric assays: Method optimization and evaluation of intra‐ and inter‐subject variation

J. T. Macgregor, Yuhchyau Chen, J. Bemis, 2020, Environmental and molecular mutagenesis.

Pig‐a gene mutation database

J. Polli, S. Dertinger, Katsuyoshi Horibata, 2019, Environmental and molecular mutagenesis.

Recommendations for conducting the rodent erythrocyte Pig‐a assay: A report from the HESI GTTC Pig‐a Workgroup

S. Dertinger, L. Recio, L. Stankowski, 2021, Environmental and molecular mutagenesis.

Aryl hydrocarbon receptor signaling plays a significant role in mediating benzo[a]pyrene- and cigarette smoke condensate-induced cytogenetic damage in vivo.

S. Dertinger, T. Gasiewicz, A. Silverstone, 2001, Carcinogenesis.

Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose-response relationships.

Stephen D Dertinger, Steven M Bryce, Jeffrey C Bemis, 2010, Mutation research.

Abstracts of the 33 rd Annual Meeting of the United Kingdom Environmental Mutagen Society, 12 th - 14 th July 2010 at the University of Derby, UK. Photo geno toxicity – science without application?

S. Dertinger, M. Cooke, A. Lynch, 2010 .

Glycosylphosphatidylinositol (GPI) anchored protein deficiency serves as a reliable reporter of Pig‐a gene Mutation: Support from an in vitro assay based on L5178Y/Tk+/− cells and the CD90.2 antigen

J. Bemis, S. Dertinger, Javier R Revollo, 2018, Environmental and molecular mutagenesis.

Three lessons for genetic toxicology from baseball analytics

Stephen D Dertinger, S. Dertinger, 2017, Environmental and molecular mutagenesis.

Assessing the Quality and Making Appropriate Use of Historical Negative Control Data: A Report of the International Workshop on Genotoxicity Testing (IWGT).

K. Witt, S. Dertinger, G. Douglas, 2023, Environmental and molecular mutagenesis.

The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup.

K. Witt, S. Dertinger, J. Tanir, 2015, Mutation research. Genetic toxicology and environmental mutagenesis.

Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose-response relationships.

J. Bemis, S. Dertinger, Steven M. Bryce, 2010, Mutation research.

Flow cytometric analysis of Pig‐a gene mutation and chromosomal damage induced by procarbazine hydrochloride in CD‐1 mice

J. T. Macgregor, J. Bemis, S. Dertinger, 2013, Environmental and molecular mutagenesis.

Intra‐ and inter‐laboratory reproducibility of the rat blood Pig‐a gene mutation assay

A. Elhajouji, J. Bemis, S. Dertinger, 2020, Environmental and molecular mutagenesis.

Response kinetics of radiation-induced micronucleated reticulocytes in human bone marrow culture.

Yuhchyau Chen, S. Dertinger, Y. Tsai, 2011, Mutation research.