Xiaoguang Lei

发表

Total synthesis of the G2/M DNA damage checkpoint inhibitor psilostachyin C.

Chao Li, Shanghui Tu, Shuguang Wen, 2011, The Journal of organic chemistry.

Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis.

C. Li, Xiaodong Wang, She Chen, 2016, Cell chemical biology.

Stereocontrolled synthesis of a complex library via elaboration of angular epoxyquinol scaffolds.

Xiaoguang Lei, John A Porco, Xiaoguang Lei, 2005, The Journal of organic chemistry.

Second Generation TQ-Ligation for Cell Organelle Imaging.

She Chen, Lin Li, Xiaoguang Lei, 2015, ACS chemical biology.

Crystal structure of the FTO protein reveals basis for its substrate specificity

Qiang Wang, Xiaoguang Lei, Zhifu Han, 2010, Nature.

Total synthesis and structure assignment of (+)-hexacyclinol.

Shun Su, Xiaoguang Lei, John A Porco, 2006, Angewandte Chemie.

Identification of Novel Epoxide Inhibitors of Hepatitis C Virus Replication Using a High-Throughput Screen

S. Schreiber, N. Sakamoto, Wenyu Lin, 2007, Antimicrobial Agents and Chemotherapy.

Total synthesis of the ubiquitin-activating enzyme inhibitor (+)-panepophenanthrin.

Xiaoguang Lei, John A Porco, Xiaoguang Lei, 2003, Angewandte Chemie.

Total synthesis of (±)-antroquinonol.

Xiaoguang Lei, Xiaoming Wang, Chao Du, 2019, Organic & biomolecular chemistry.

Total Synthesis of the Ubiquitin-Activating Enzyme Inhibitor (+)-Panepophenanthrin.

Xiaoguang Lei, J. Porco, Richard P. Johnson, 2003 .

Small molecules capable of activating DNA methylation–repressed genes targeted by the p38 mitogen-activated protein kinase pathway

W. Shao, Xiaoguang Lei, Hailin Wang, 2018, The Journal of Biological Chemistry.

A bioorthogonal ligation enabled by click cycloaddition of o-quinolinone quinone methide and vinyl thioether.

Xiaoguang Lei, T. Dong, Qiang Li, 2013, Journal of the American Chemical Society.

Focused Genome Mining of Structurally Related Sesterterpenes: Enzymatic Formation of Enantiomeric and Diastereomeric Products.

A. Minami, Xiaoguang Lei, M. Yamazaki, 2017, Organic letters.

Synthesis and biological evaluation of Aspergillomarasmine A derivatives as novel NDM-1 inhibitor to overcome antibiotics resistance.

Xiaoguang Lei, Lixin Zhang, Fuhang Song, 2017, Bioorganic & medicinal chemistry.

Protecting-group-free syntheses of ent-kaurane diterpenoids: [3+2+1] cycloaddition/cycloalkenylation approach.

Xiaoguang Lei, Benke Hong, Yuichiro Kadonaga, 2020, Journal of the American Chemical Society.

Total Synthesis and Structural Reassignment of Aspergillomarasmine A.

Xiaoguang Lei, Benke Hong, Fan Wu, 2016, Angewandte Chemie.

Styryllactones from Goniothalamus tamirensis.

R. Andersen, Xiaoguang Lei, S. Jungsuttiwong, 2020, Phytochemistry.

Dissecting Programmed Cell Death with Small Molecules.

Xiaoguang Lei, Yingjie Bai, Hiu-chor. Lam, 2020, Accounts of chemical research.

Improving mass spectrometry analysis of protein structures with arginine-selective chemical cross-linkers

M. Dong, N. Huang, Yue-He Ding, 2019, Nature Communications.

A Fast Lysine Cross-linker DOPA Enables Mass Spectrometry Analyses of Protein Unfolding and Weak Protein-protein Interactions

M. Dong, N. Huang, Y. Zhou, 2020, bioRxiv.

FAD-dependent enzyme-catalysed intermolecular [4+2] cycloaddition in natural product biosynthesis

K. Houk, N. Huang, A. Minami, 2020, Nature Chemistry.

Total syntheses of menisporphine and daurioxoisoporphine C enabled by photoredox-catalyzed direct C-H arylation of isoquinoline with aryldiazonium salt.

Xiaoguang Lei, Xiaoyun Zhang, Jing Zhang, 2014, The Journal of organic chemistry.

Synthesis of a polymer-supported anthracene and its application as a dienophile scavenger.

Xiaoguang Lei, J. Porco, 2004, Organic letters.

A bioassay-guided fractionation system to identify endogenous small molecules that activate plasma membrane H+-ATPase activity in Arabidopsis

Xiaoguang Lei, Yujiao Wu, Yan Guo, 2017, Journal of experimental botany.

Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels

S. F. Yan, Chuangye Yan, X. Gong, 2015, Science.

Computation-Guided Development of the "Click" ortho-Quinone Methide Cycloaddition with Improved Kinetics.

Xiaoguang Lei, Shuo-qing Zhang, Xin Hong, 2020, Organic letters.

Access to the 2H-Tetrahydro-4,6-dioxo-1,2-oxazine Ring System from Nitrone via a Tandem Nucleophilic Addition and Transesterification Reaction.

Xiaoguang Lei, Shaoqiang Yang, Daohong Liao, 2016, Organic letters.

Total Syntheses of Natural Metallophores Staphylopine and Aspergillomarasmine A.

Xiaoguang Lei, Jian Zhang, Sanshan Wang, 2017, The Journal of organic chemistry.

Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression

Edwin F. Juarez, J. Mesirov, J. Dixon, 2019, Proceedings of the National Academy of Sciences.

Chrysomycin A Derivatives for the Treatment of Multi-Drug-Resistant Tuberculosis

Xiaoguang Lei, X. Xia, Xueting Liu, 2020, ACS central science.

Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol

T. Chou, Xiaoguang Lei, J. H. Lee, 2011, Proceedings of the National Academy of Sciences.

Ortho-Quinone Methide Finds Its Application in Bioorthogonal Ligation

Xiaoguang Lei, Xiaoyun Zhang, T. Dong, 2014 .

Probing the anticancer mechanism of (-)-ainsliatrimer A through diverted total synthesis and bioorthogonal ligation.

C. Li, Xiaoguang Lei, T. Dong, 2014, Angewandte Chemie.

De novo synthesis, structural assignment and biological evaluation of pseudopaline, a metallophore produced by Pseudomonas aeruginosa† †Electronic supplementary information (ESI) available. CCDC 1850196 and 1863986. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039

Xiaoguang Lei, Hong C Shen, Rongwen Yang, 2019, Chemical science.

Site-selective and metal-free aliphatic C-H oxidation enabled synthesis of [5,24,25-D3]-(25S)-Δ(7)-dafachronic acid.

Xiaoguang Lei, Tie-Mei Li, Mengqi Dong, 2015, Chemistry.

Biosynthetic Intermediate Probes for Visualizing and Identifying the Biosynthetic Enzymes of Plant Metabolites

Xiaoguang Lei, Lei Gao, 2020, Chembiochem : a European journal of chemical biology.

Enzymatic cascade reactions for the efficient synthesis of natural products

Xiaoguang Lei, Dongshan Wu, 2022, Tetrahedron.

Biomimetic syntheses of (-)-gochnatiolides A-C and (-)-ainsliadimer B.

Chao Li, Xiaoguang Lei, Weidong Zhang, 2012, Journal of the American Chemical Society.

A biomimetic total synthesis of (+)-ainsliadimer A.

Chao Li, Xiaoguang Lei, Xue‐Feng Yu, 2010, Organic letters.

Efficient generation of ortho-quinone methide: application to the biomimetic syntheses of (±)-schefflone and tocopherol trimers.

Xiaoguang Lei, Daohong Liao, Houhua Li, 2012, Organic letters.

Collective Synthesis of Lycopodium Alkaloids and Tautomer Locking Strategy for the Total Synthesis of (−)-lycojapodine A

Xiaoguang Lei, Xiaoming Wang, Benke Hong, 2022 .

Photoinduced Skeletal Rearrangements Reveal Radical-Mediated Synthesis of Terpenoids

Xiaoguang Lei, H. Lou, Zhi‐Xiang Yu, 2019, Chem.

Syntheses of Skeletally Diverse Tetracyclic Isodon Diterpenoid Scaffolds Guided by Dienyne Radical Cyclization Logic.

Xiaoguang Lei, Zhen Wang, Houhua Li, 2020, Organic letters.

Scalable Total Synthesis of rac-Jungermannenones B and C.

Xiaoguang Lei, Zhi‐Xiang Yu, Pei-jun Cai, 2016, Angewandte Chemie.

Enantioselective Total Synthesis of (-)-Incarviatone A.

Chao Li, Xiaoguang Lei, Benke Hong, 2015, Journal of the American Chemical Society.

Fawcettimine-Type Lycopodium Alkaloids as a Driving Force for Discoveries in Organic Synthesis.

Xiaoguang Lei, Houhua Li, 2018, Chemical record.

Total syntheses of (-)-huperzine Q and (+)-lycopladines B and C.

Xiaoguang Lei, Benke Hong, Jing Zhang, 2015, Angewandte Chemie.

Total Syntheses of Lycopodium Alkaloids ( + )-Fawcettimine , ( + )-Fawcettidine , and ( )-8-Deoxyserratinine * *

Xiaoguang Lei, Xiaoming Wang, Houhua Li, 2011 .

Late-Stage Diversification of Natural Products

Xiaoguang Lei, T. Luo, Benke Hong, 2020, ACS central science.

Syntheses of [1,2,4]triazolo[1,5-a]benzazoles enabled by the transition-metal-free oxidative N-N bond formation.

Xiaoguang Lei, Jinyi Bai, Xiang Li, 2016, Chemical communications.

Biomimetic syntheses and structural elucidation of the apoptosis-inducing sesquiterpenoid trimers: (−)-ainsliatrimers A and B

Chao Li, Xiaoguang Lei, T. Dong, 2013 .

Diversity-oriented synthesis of bicyclic ring systems via a conjugate addition/aldol/RCM process

Chao Li, Xiaoguang Lei, Xiaoming Wang, 2013, Science China Chemistry.

Stereoselective synthesis of the C16–C25 fragment of alchivemycins A and B

Xiaoguang Lei, Xiaoming Wang, Shaoqiang Yang, 2021, Tetrahedron Letters.

Total synthesis of the diazobenzofluorene antibiotic (-)-kinamycin C1.

Xiaoguang Lei, J. Porco, 2006, Journal of the American Chemical Society.

Divergent Total Synthesis of Chaetoglines C to F.

Xiaoguang Lei, R. Tan, Yaocheng Shi, 2019, The Journal of organic chemistry.

Enzymatic control of endo- and exo-stereoselective Diels–Alder reactions with broad substrate scope

K. Houk, Xiaoguang Lei, Xinshui Yu, 2021, Nature Catalysis.

Recent advances in target identification by natural product based chemical probes

Ting Dong, Benke Hong, Xiaoguang Lei, 2016, Science China Chemistry.

Synthesis and mode of action of oligomeric sesquiterpene lactones.

Chao Li, Xiaoguang Lei, Alexander X. Jones, 2016, Natural product reports.

Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition.

Xiaoguang Lei, S. Danishefsky, 2008, Advanced synthesis & catalysis.

Chiral Boron Complex-Promoted Asymmetric Diels-Alder Cycloaddition and Its Application in Natural Product Synthesis.

Xiaoguang Lei, Xia Li, Jianguang Han, 2016, The Journal of organic chemistry.

Enantioselective Total Syntheses of Kuwanon X, Kuwanon Y, and Kuwanol A.

Xiaoguang Lei, Lei Gao, Jianguang Han, 2016, Organic letters.

Enantioselective biomimetic total syntheses of kuwanons I and J and brosimones A and B.

Xiaoguang Lei, Xia Li, Wenjun Zhao, 2014, Angewandte Chemie.

Studies towards the synthesis of the functionalized C3–C14 decalin framework of alchivemycin A

Xiaoguang Lei, Shaoqiang Yang, Xiaofei Li, 2016 .

Diversity-oriented synthesis of cyclohexenes by combining enzymatic intermolecular Diels-Alder reactions and decarboxylative functionalizations

Xiaoguang Lei, Q. Ding, Lei Gao, 2022, Chem Catalysis.

Selective alkene metathesis in the total synthesis of complex natural product.

Xiaoguang Lei, Houhua Li, 2012, Topics in current chemistry.

Biomimetic synthesis of rhytidenone A and elucidation of mode of action of the cytotoxic rhytidenone F.

Xiaoguang Lei, K. Pudhom, Hiu-chor. Lam, 2019, Angewandte Chemie.

Exploring the Binding Proteins of Glycolipids with Bifunctional Chemical Probes.

Niu Huang, Yu Zhou, Xiaoguang Lei, 2016, Angewandte Chemie.

Staphylopine and pseudopaline dehydrogenase from bacterial pathogens catalyze reversible reactions and produce stereospecific metallophores

A. Lamb, Xiaoguang Lei, Jian Zhang, 2019, The Journal of Biological Chemistry.

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

Xiaodong Wang, Xiaoguang Lei, Xiaodong Wang, 2012, Cell.

Necrosulfonamide inhibits necroptosis by selectively targeting the mixed lineage kinase domain-like protein

Xiaoguang Lei, S. He, Xiaodong Wang, 2014 .

Recent applications of C H functionalization in complex molecule synthesis

Xiaoguang Lei, Kaiqi Chen, 2018, Current Opinion in Green and Sustainable Chemistry.

Tuning an Imine Reductase for the Asymmetric Synthesis of Azacycloalkylamines by Concise Structure-Guided Engineering.

Xiaoguang Lei, Yaqing Ma, Zhoutong Sun, 2022, Angewandte Chemie.

Development of an effective fluorescence probe for discovery of aminopeptidase inhibitors to suppress biofilm formation

Xiaoguang Lei, Luyan Z. Ma, Jian Zhang, 2019, The Journal of Antibiotics.

Enzymatic Formation of a Skipped Methyl-Substituted Octaprenyl Side Chain of Longestin (KS-505a): Involvement of Homo-IPP as a Common Extender Unit.

A. Minami, Xiaoguang Lei, T. Dairi, 2018, Angewandte Chemie.

13-step Enantioselective Total Synthesis of (+)-Jungermatrobrunin A.

Xiaoguang Lei, Benke Hong, Yuichiro Kadonaga, 2019, Angewandte Chemie.

Enantioselective Total Synthesis of (+)‐Jungermatrobrunin A

Xiaoguang Lei, Benke Hong, Yuichiro Kadonaga, 2019, Angewandte Chemie.

New Strategies in the Efficient Total Syntheses of Polycyclic Natural Products.

Xiaoguang Lei, Benke Hong, Jin Wang, 2020, Accounts of chemical research.

Chemoenzymatic Total Syntheses of Artonin I with an Intermolecular Diels–Alderase

Xiaoguang Lei, Lei Gao, Xiaojing Liu, 2020, Biotechnology journal.

Recent Advances in the Total Synthesis of Prenylflavonoid and Related Diels–Alder Natural Products

Xiaoguang Lei, Alexander X. Jones, Jianguang Han, 2015, Synthesis.

Roles of the CSE1L-mediated nuclear import pathway in epigenetic silencing

W. Shao, Xiaoguang Lei, Hailin Wang, 2018, Proceedings of the National Academy of Sciences.

Small-molecule activation of the TRAIL receptor DR5 in human cancer cells.

Xiaodong Wang, She Chen, Xiaoguang Lei, 2013, Nature chemical biology.

Using Small Molecules to Dissect Non‐apoptotic Programmed Cell Death: Necroptosis, Ferroptosis, and Pyroptosis

Xiaoguang Lei, T. Dong, Xiaohui Liu, 2015, Chembiochem : a European journal of chemical biology.

OSMAC strategy integrated with molecular networking discovery peniciacetals A-I, nine new meroterpenoids from the mangrove-derived fungus Penicillium sp. HLLG-122.

Xiaoguang Lei, Linhu Zou, Guangying Chen, 2022, Bioorganic chemistry.

Bioorthogonal Metabolic DNA Labelling using Vinyl Thioether-Modified Thymidine and o-Quinolinone Quinone Methide.

Xiaoguang Lei, Xiaoyun Zhang, Qiang Li, 2018, Chemistry.

Chemical probing reveals insights into the signaling mechanism of inflammasome activation

Shan Li, Xiaoguang Lei, F. Shao, 2010, Cell Research.

Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome.

Xiaodong Wang, Xiaoguang Lei, Lingjun Meng, 2017, Journal of medicinal chemistry.

s mall-molecule activation of the tra IL receptor dr 5 in human cancer cells

Xiaodong Wang, Xiaoguang Lei, Lin Li, 2012 .

A nature-inspired concise synthesis of (+)-ent-chromazonarol

Xiaoguang Lei, Jiehui Huang, 2013, Science China Chemistry.

Ainsliadimer A selectively inhibits IKKα/β by covalently binding a conserved cysteine

Li Li, Niu Huang, Xiaoguang Lei, 2015, Nature Communications.

Evaluation of chemical cross-linkers for in-depth structural analysis of G protein-coupled receptors through cross-linking mass spectrometry.

Suwen Zhao, Xiaoguang Lei, W. Shui, 2020, Analytica chimica acta.

Biomimetic Synthesis of Rhytidenone A and Mode of Action of Cytotoxic Rhytidenone F

Xiaoguang Lei, K. Pudhom, Hiu-chor. Lam, 2020, Angewandte Chemie.

Induction of chemoprotective phase 2 enzymes by ginseng and its components.

C. Flexner, Xiaoguang Lei, J. Fahey, 2009, Planta medica.

Carboxylate-Selective Chemical Cross-Linkers for Mass Spectrometric Analysis of Protein Structures.

M. Dong, D. Tan, Zhirong Liu, 2018, Analytical chemistry.

Inhibition of PU.1 ameliorates metabolic dysfunction and non-alcoholic steatohepatitis.

Luis C. Santos, Yi Wang, J. Qin, 2020, Journal of hepatology.

Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors.

Xiaoguang Lei, Ashfaq Ahmad, Q. Hao, 2020, Bioorganic & medicinal chemistry.

Identification of spirobisnaphthalene derivatives with anti-tumor activities from the endophytic fungus Rhytidhysteron rufulum AS21B.

Xiaoguang Lei, K. Pudhom, Zongwei Yue, 2017, Bioorganic & medicinal chemistry.

An Arabidopsis Secondary Metabolite Directly Targets Expression of the Bacterial Type III Secretion System to Inhibit Bacterial Virulence.

Yang Bai, Jian-Min Zhou, Jian Zhang, 2020, Cell host & microbe.

Covalent Probe Finds Carboxylic Acid.

Xiaoguang Lei, Alexander X. Jones, Xiaoyun Zhang, 2017, Cell chemical biology.

Biomimetic total synthesis of tricycloillicinone and mechanistic studies toward the rearrangement of prenyl phenyl ethers.

Xiaoguang Lei, S. Danishefsky, M. Dai, 2008, Tetrahedron letters.

(3R, 9R, 10R)-Panaxytriol: A molecular-based nutraceutical with possible application to cancer prevention and treatment.

C. Flexner, Xiaoguang Lei, J. Fahey, 2008, Tetrahedron letters.

Convergent synthesis of a complex oxime library using chemical domain shuffling.

Aaron B. Beeler, Erin L Eastwood, S. Schaus, 2005, Organic letters.

Diversity-oriented synthesis of Lycopodium alkaloids inspired by the hidden functional group pairing pattern

Jing Zhang, Xiaoming Wang, Jinbao Wu, 2014, Nature Communications.

Function‐Oriented Natural Product Synthesis

Xiaoguang Lei, Fan Wu, Kaiqi Chen, 2020 .

Strategies toward the biomimetic syntheses of oligomeric sesquiterpenoids.

Chao Li, Xiaoguang Lei, 2014, The Journal of organic chemistry.

Chemoproteomic Profiling of Bile Acid Interacting Proteins

Xiaoguang Lei, Xiaoguang Lei, Qiang Li, 2017, ACS central science.

Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states

Chao Liu, Si-Min He, Dan Tan, 2016, eLife.

Human Endogenous Natural Products.

Xiaoguang Lei, Yingjie Bai, Liyun Zhang, 2021, Progress in the chemistry of organic natural products.

Pterisolic Acid B is a Nrf2 Activator by Targeting C171 within Keap1-BTB Domain

She Chen, Lin Li, Xiaoguang Lei, 2016, Scientific Reports.

Advanced in the Synthesis of Kaurane Diterpenoids

Xiaoguang Lei, Xiaoguang Lei, Mingjun Du, 2015 .

Applications ofortho-Quinone Methides in the Synthesis of Natural Products

Xiaoguang Lei, W. Ai, Daohong Liao, 2015 .

Chiral Boron Complex‐Promoted Asymmetric Diels—Alder Cycloaddition and Its Application in Natural Product Synthesis.

Xiaoguang Lei, Alexander X. Jones, Xia Li, 2016 .

Absolute quantification of a steroid hormone that regulates development in Caenorhabditis elegans.

M. Dong, She Chen, Xiaoguang Lei, 2013, Analytical chemistry.

No Significant Increase in the Δ4- and Δ7-Dafachronic Acid Concentration in the Long-Lived glp-1 Mutant, nor in the Mutants Defective in Dauer Formation

M. Dong, Xiaoguang Lei, Shan Lu, 2015, G3: Genes, Genomes, Genetics.