Hyun-Ju Park

发表

Increased expression of p27 is associated with the cisplatin resistance in gastric cancer cell line YCC-3

T. Le, Y. Seo, C. Ryu, 2010, Archives of pharmacal research.

A new curcumin derivative, HBC, interferes with the cell cycle progression of colon cancer cells via antagonization of the Ca2+/calmodulin function.

So-Jung Park, H. Kwon, Hyun-Ju Park, 2004, Chemistry & biology.

CoMFA and coMSIA 3d qsar studies on pimarane cyclooxygenase-2 (COX-2) inhibitors

Hyun-Ju Park, Kwang-Ok Lee, Young-ho Kim, 2004, Archives of pharmacal research.

Novel molecular mechanism for actinomycin D activity as an oncogenic promoter G-quadruplex binder.

Hyun-Jin Kang, Hyun-Ju Park, 2009, Biochemistry.

In silico identification of poly(ADP-ribose)polymerase-1 inhibitors and their chemosensitizing effects against cisplatin-resistant human gastric cancer cells.

T. Le, Hyun-Ju Park, J. Suh, 2013, Bioorganic & medicinal chemistry letters.

Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-β type I receptor kinase as cancer immunotherapeutic/antifibrotic agent.

K. S. Rao, So-Jung Park, H. Lee, 2014, Journal of medicinal chemistry.

4-([1,2,4]Triazolo[1,5-a]pyridin-6-yl)-5(3)-(6-methylpyridin-2-yl)imidazole and -pyrazole derivatives as potent and selective inhibitors of transforming growth factor-β type I receptor kinase.

So-Jung Park, Hyun-Ju Park, M. Krishnaiah, 2014, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-β type 1 receptor kinase inhibitors.

K. S. Rao, Hyun-Ju Park, M. Krishnaiah, 2012, European journal of medicinal chemistry.

Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors.

K. S. Rao, Hyun-Ju Park, M. Krishnaiah, 2011, European journal of medicinal chemistry.

Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity.

Young Hoon Jung, In Su Kim, Hyun-Ju Park, 2016, European journal of medicinal chemistry.

Z-DNA binding proteins as targets for structure-based virtual screening.

Young-Ho Lee, Doyoun Kim, K. Kim, 2010, Current drug targets.

Rational design of an indolebutanoic acid derivative as a novel aldose reductase inhibitor based on docking and 3D QSAR studies of phenethylamine derivatives.

Ki Duk Park, Hyun-Ju Park, Jakyung Yoo, 2003, Journal of medicinal chemistry.

Structural basis for depletion of heat shock protein 90 client proteins by deguelin.

W. Hong, Hyun-Ju Park, J. Myers, 2007, Journal of the National Cancer Institute.

Discovery of a Simplified Deguelin Analog as an HSP90 C-terminal Inhibitor for HER2-positive Breast Cancer.

Hyun-Ju Park, Jihyae Ann, Jeewoo Lee, 2021, Bioorganic & medicinal chemistry letters.

A novel HSP90 inhibitor targeting the C-terminal domain attenuates trastuzumab resistance in HER2-positive breast cancer

Ji Young Kim, Hyun-Ju Park, J. Seo, 2020, Molecular Cancer.

Antithrombotic effect of SP‐8008, a benzoic acid derivative, through the selective inhibition of shear stress‐induced platelet aggregation

J. Chung, Hyun-Ju Park, Kiho Lee, 2020, British journal of pharmacology.

Cinnamamides, Novel Liver X Receptor Antagonists that Inhibit Ligand-Induced Lipogenesis and Fatty Liver

Jiwon Kim, So-Jung Park, Byung-Hoon Lee, 2015, The Journal of Pharmacology and Experimental Therapeutics.

Novel Liver X Receptor Antagonists Inhibit Ligand-induced Lipogenesis and Fatty Liver

So-Jung Park, Byung-Hoon Lee, Hyun-Ju Park, 2015 .

Identification and Structural Analysis of New Nrf2 Activators by Mechanism‐Based Chemical Transformation of 15‐Deoxy‐Δ12, 14‐PGJ2

Jeeyeon Lee, Y. Surh, Hyun-Ju Park, 2016, Chembiochem : a European journal of chemical biology.

Synthesis, biological evaluation and molecular modelling of 2,4-disubstituted-5-(6-alkylpyridin-2-yl)-1H-imidazoles as ALK5 inhibitors

So-Jung Park, H. Lee, Hyun-Ju Park, 2020, Journal of enzyme inhibition and medicinal chemistry.

Identification of RNA pseudoknot-binding ligand that inhibits the -1 ribosomal frameshifting of SARS-coronavirus by structure-based virtual screening.

So-Jung Park, Yang‐Gyun Kim, Hyun-Ju Park, 2011, Journal of the American Chemical Society.

Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity.

So-Jung Park, Jeeyeon Lee, Sonia J. Park, 2016, Cancer research.

Compound 9a, a novel synthetic histone deacetylase inhibitor, protects against septic injury in mice by suppressing MAPK signalling

Hyun-Ju Park, Sun-Mee Lee, So-Jin Kim, 2015, British journal of pharmacology.

Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin.

H. Kwon, B. Shim, Hyun-Ju Park, 2003, Chemistry & biology.

Discovery of novel anti-breast cancer agents derived from deguelin as inhibitors of heat shock protein 90 (HSP90).

Ji Young Kim, Hyun-Ju Park, Raghaba Sahu, 2020, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 4(5)-(6-methylpyridin-2-yl)imidazoles and -pyrazoles as transforming growth factor-beta type 1 receptor kinase inhibitors.

Hyun-Ju Park, Jakyung Yoo, Y. Sheen, 2010, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.

Hyun-Jin Kang, Jong-Wha Jung, T. Le, 2008, Journal of Medicinal Chemistry.

Antimicrobial effects of topical skin cream containing natural oil mixtures against Staphylococcus pseudintermedius and Malassezia pachydermatis.

Hyun-Ju Park, Sunwoo Kim, Jae-Ik Han, 2016 .

QSAR Model for Predicting the Cannabinoid Receptor 1 Binding Affinity and Dependence Potential of Synthetic Cannabinoids

So-Jung Park, Hyun-Ju Park, C. Jang, 2020, Molecules.

Identification of protoberberine alkaloids as novel histone methyltransferase G9a inhibitors by structure-based virtual screening

Xiao Lin, Jie Chen, Kyoung Jin Park, 2018, Journal of Computer-Aided Molecular Design.

Novel thiophenyl C-aryl glucoside SGLT2 inhibitors as potential antidiabetic agents.

Jong Yup Kim, Hyun-Ju Park, Jinhwa Lee, 2011, Bioorganic & medicinal chemistry.

Thiazolylmethyl ortho-substituted phenyl glucoside library as novel C-aryl glucoside SGLT2 inhibitors.

Min Ju Kim, Hyun-Ju Park, Jinhwa Lee, 2011, European journal of medicinal chemistry.

Chemical screen uncovers novel structural classes of inhibitors of the papain-like protease of coronaviruses

Hyun-Ju Park, Wonsik Lee, In-woo Kim, 2022, iScience.

A versatile asymmetric synthesis of highly enantiomerically enriched 12(S)-HETE via a combination of enzymatic and chemical processes

Hyun-Ju Park, Seung‐Yong Seo, Yong-Sil Lee, 2002 .

Bioactive compounds from the seeds of Amomum tsaoko Crevost et Lemaire, a Chinese spice as inhibitors of sphingosine kinases, SPHK1/2

Seulah Lee, S. Kim, Hyun-Ju Park, 2019, RSC advances.

Absolute Configuration and Corrected NMR Assignment of 17-Hydroxycyclooctatin, a Fused 5-8-5 Tricyclic Diterpene.

Hyun-Ju Park, K. Kang, C. Beemelmanns, 2020, Journal of natural products.

Fine tuning of 4,6-bisphenyl-2-(3-alkoxyanilino)pyrimidine focusing on the activity-sensitive aminoalkoxy moiety for a therapeutically useful inhibitor of receptor for advanced glycation end products (RAGE).

Jeeyeon Lee, Hyun-Ju Park, Y. Suh, 2015, Bioorganic & medicinal chemistry.

Changes in Drug Elution Concentration and Physical Characteristics of Soft Contact Lenses Depending on the Initiator and Crosslinker

Hyun-Ju Park, Hyun Mee Lee, 2014 .

Bioactivity‐Guided Isolation of Anti‐Inflammatory Constituents of the Rare Mushroom Calvatia nipponica in LPS‐Stimulated RAW264.7 Macrophages

Seulah Lee, Hyun-Ju Park, K. Kang, 2018, Chemistry & biodiversity.

Study of the stability of carbocations by chlorosulfonyl isocyanate reaction with ethers

Hyun-Ju Park, G. Han, L. Jeong, 2002 .

Evidence for a common molecular basis for sequence recognition of N3-guanine and N3-adenine DNA adducts involving the covalent bonding reaction of (+)-CC-1065

Hyun-Ju Park, 2002, Archives of pharmacal research.

Synthesis and phosphodiesterase 5 inhibitory activity of new sildenafil analogues containing a phosphonate group in the 5(')-sulfonamide moiety of phenyl ring.

Hyun-Ju Park, Dae-Kee Kim, Jung Young Lee, 2004, Bioorganic & medicinal chemistry letters.

Pyrazole-5-carboxamides, novel inhibitors of receptor for advanced glycation end products (RAGE).

Hyun-Ju Park, Y. Suh, Kyeojin Kim, 2014, European journal of medicinal chemistry.

Total synthesis of (+)-Brefeldin A.

Hyun-Ju Park, Seung‐Yong Seo, Yong-Sil Lee, 2002, The Journal of organic chemistry.

C. Ryu, H. Lee, Hyun-Ju Park, 2013, Molecular medicine reports.

Methylsulfonylpyrazolyl oxadiazoles and thiadiazoles as potent, orally bioavailable cannabinoid-1 receptor antagonists for the treatment of obesity.

Min Ju Kim, Chong-Hwan Chang, Hyun-Ju Park, 2009, Future medicinal chemistry.

3D-QSAR studies on sildenafil analogues, selective phosphodiesterase 5 inhibitors.

J. Y. Lee, Hyun-Ju Park, Jakyung Yoo, 2007, Bioorganic & medicinal chemistry letters.

Synthesis of N-protected allylic amines from allyl ethers

Hyun-Ju Park, G. Han, M. H. Lee, 2001 .

Design, synthesis, and structure–activity relationship of carbamate-tethered aryl propanoic acids as novel PPARα/γ dual agonists

Hyun-Ju Park, Mi Kyung Kim, Jakyung Yoo, 2007 .

Syntheses of (±)-homoepibatidine analogues

Hyun-Ju Park, Y. Jung, W. Ham, 2002, Archives of pharmacal research.

Enantioseparation of aromatic amino acids and amino acid esters by capillary electrophoresis with crown ether and prediction of enantiomer migration orders by a three‐dimensional quantitative structure‐property relationship/comparative field analysis model

Hyun-Ju Park, Wonjae Lee, Kyoung-Rae Kim, 2004, Electrophoresis.

G-quadruplex binding ligands: from naturally occurring to rationally designed molecules.

Hyun-Ju Park, Sujin Han, Tuong Vy Thi Le, 2012, Current pharmaceutical design.

Ligand-based design, synthesis, and biological evaluation of 2-aminopyrimidines, a novel series of receptor for advanced glycation end products (RAGE) inhibitors.

Hyun-Ju Park, Y. Suh, H. Hong, 2012, Journal of medicinal chemistry.

Biarylpyrazolyl oxadiazole as potent, selective, orally bioavailable cannabinoid-1 receptor antagonists for the treatment of obesity.

Chong-Hwan Chang, Hyun-Ju Park, H. Yun, 2008, Journal of medicinal chemistry.

Identification of novel scaffolds for potential anti-Helicobacter pylori agents based on the crystal structure of H. pylori 3-deoxy-d-manno-octulosonate 8-phosphate synthase (HpKDO8PS).

Hyun-Ju Park, H. Yoon, Kiyoung Lee, 2016, European journal of medicinal chemistry.

Isoamericanoic Acid B from Acer tegmentosum as a Potential Phytoestrogen

Seulah Lee, Hyun-Ju Park, Hae-Jeung Lee, 2018, Nutrients.

Structure-activity relationship study of thiazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors.

Hyun-Ju Park, Seung Yeop Baek, Y. Jung, 2019, Bioorganic & medicinal chemistry.

Lobatamunsolides A–C, Norlignans from the Roots of Pueraria lobata and their Nitric Oxide Inhibitory Activities in Macrophages

Hyun-Ju Park, Jae Sik Yu, Ki Hyun Kim, 2019, Biomolecules.

PBT-6, a Novel PI3KC2γ Inhibitor in Rheumatoid Arthritis

Hyun-Ju Park, Soon-Sun Hong, K. Jung, 2019, Biomolecules & therapeutics.

Development of a novel Hsp90 inhibitor NCT-50 as a potential anticancer agent for the treatment of non-small cell lung cancer

Hyun-Ju Park, Ho Jin Lee, Jihyae Ann, 2018, Scientific Reports.

A novel C-terminal heat shock protein 90 inhibitor that overcomes STAT3-Wnt-β-catenin signaling-mediated drug resistance and adverse effects

Hyun-Ju Park, Ho Jin Lee, Jihyae Ann, 2022, Theranostics.

Computer-aided identification of ligands for GPCR anti-obesity targets.

Hyun-Ju Park, Jakyung Yoo, K. Min, 2009, Current topics in medicinal chemistry.

Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer

Min Gyu Lee, Hyun-Ju Park, Jeung-Whan Han, 2019, BMC Cancer.

Synthesis and Evaluation of a Novel Deguelin Derivative, L80, which Disrupts ATP Binding to the C-terminal Domain of Heat Shock Protein 90

So-Jung Park, Hyun-Ju Park, Ho-Yyoung Lee, 2015, Molecular Pharmacology.

Synthesis and Evaluation of a Novel Deguelin Derivative , L 80 , which Disrupts ATP Binding to the C-terminal Domain of Heat Shock Protein 90

So-Jung Park, Hyun-Ju Park, Ho-Yyoung Lee, 2015 .

A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy

Gordon Mills, Yoo-Shin Kim, Woo-Young Kim, 2008, Cancer Prevention Research.

Induction of Reversible Complexes between Eukaryotic DNA Topoisomerase I and DNA-containing Oxidative Base Damages

Y. Pommier, M. Bjornsti, J. Essigmann, 1999, The Journal of Biological Chemistry.

LY294002 inhibits monocyte chemoattractant protein‐1 expression through a phosphatidylinositol 3‐kinase‐independent mechanism

Hyun-chul Lee, Hyun-Ju Park, Eun-Kyoung Choi, 2004, FEBS letters.

Analysis of Saccharomyces cerevisiae histone H3 mutants reveals the role of the alphaN helix in nucleosome function.

E. Cho, Hyun-Ju Park, Hyenchol Kim, 2008, Biochemical and biophysical research communications.

Identification of novel ligands for the RNA pseudoknot that regulate −1 ribosomal frameshifting

So-Jung Park, Hyun-Ju Park, Y. Jung, 2008, Bioorganic & Medicinal Chemistry.

Computer-Aided Discovery of Massonianoside B as a Novel Selective DOT1L Inhibitor.

Hyun-Ju Park, Jie Chen, 2019, ACS chemical biology.

Ring-truncated deguelin derivatives as potent Hypoxia Inducible Factor-1α (HIF-1α) inhibitors.

So-Jung Park, D. Oh, Hyun-Ju Park, 2015, European journal of medicinal chemistry.

Ginsenoside Rf inhibits cyclooxygenase-2 induction via peroxisome proliferator–activated receptor gamma in A549 cells

M. Iida, Hyun-Ju Park, M. Rhyu, 2018, Journal of ginseng research.

A peptide with alternating lysines can act as a highly specific Z-DNA binding domain

Alexander Rich, A. Rich, K. Lowenhaupt, 2006, Nucleic acids research.

Synthesis and biological evaluation of 3-(4-substituted-phenyl)-N-hydroxy-2-propenamides, a new class of histone deacetylase inhibitors.

J. Y. Lee, Y. Bang, Hyun-Ju Park, 2003, Journal of medicinal chemistry.

Structure-Activity Relationship of Sulfonyl Piperazine LpxH Inhibitors Analyzed by an LpxE-Coupled Malachite Green Assay.

Hyun-Ju Park, Jinshi Zhao, D. Kwon, 2019, ACS Infectious Diseases.

Stereoselective syntheses of (±)-epibatidine analogues

Hyun-Ju Park, W. Ham, Yong-Hyun Kim, 2002, Archives of pharmacal research.

Design, synthesis, and biological evaluation of novel 2-pyridinyl-[1,2,4] triazoles as inhibitors of transforming growth factor β1 type 1 receptor

Hyun-Ju Park, Dae-Kee Kim, Joonseop Kim, 2004 .

LXR-α antagonist meso-dihydroguaiaretic acid attenuates high-fat diet-induced nonalcoholic fatty liver.

Sonia J. Park, Byung-Hoon Lee, Hyun-Ju Park, 2014, Biochemical pharmacology.

A transcription factor hijacking to regulate RARα by using a chimeric molecule of retinoic acid and a DNA alkylator.

Hyun-Ju Park, Jiho Song, K. Min, 2011, Bioorganic & medicinal chemistry letters.

Virtual Screening for RNA-Interacting Small Molecules

Hyun-Ju Park, So-Jung Park, So-Jung Park, 2012, Biophysical approaches to translational control of gene expression.

Investigation of B,C-ring truncated deguelin derivatives as heat shock protein 90 (HSP90) inhibitors for use as anti-breast cancer agents.

Ji Young Kim, Hyun-Ju Park, Kyu-Won Kim, 2019, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of novel 2-pyridinyl-[1,2,3]triazoles as inhibitors of transforming growth factor β1 type 1 receptor

Hyun-Ju Park, Dae-Kee Kim, Joonseop Kim, 2004 .

Crystal structure of UDP‐N‐acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae in complex with UDP‐N‐acetylglucosamine and fosfomycin

B. Mikami, S. Suh, Hyun-Ju Park, 2008, Proteins.

DNA structural perturbation induced by the CPI-derived DNA interstrand cross-linker: molecular mechanisms for the sequence specific recognition

Hyun-Ju Park, 2001, Archives of pharmacal research.

Biochemical characterization and preliminary X-ray crystallographic study of the domains of human ZBP1 bound to left-handed Z-DNA.

S. Ha, K. Kim, Hyun-Ju Park, 2006, Biochimica et biophysica acta.

In silico identification of novel ligands for G-quadruplex in the c-MYC promoter

Hyun-Ju Park, Hyun-Jin Kang, Hyun-Jin Kang, 2015, Journal of Computer-Aided Molecular Design.

Synthesis and biological evaluation of novel N-benzyltriazolyl-hydroxamate derivatives as selective histone deacetylase 6 inhibitors.

Hyun-Ju Park, Sungjun Kong, Y. Jung, 2023, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of novel 2-pyridinyl-[1,2,3]triazoles as inhibitors of transforming growth factor beta 1 type 1 receptor.

Hyun-Ju Park, Dae-Kee Kim, Joonseop Kim, 2004, Bioorganic & medicinal chemistry letters.

Role of Helix 8 in Dopamine Receptor Signaling

K. Chung, Hyun-Ju Park, Xiaodi Zhao, 2019, Biomolecules & therapeutics.

Design, Synthesis, and Biological Evaluation of Imidazopyrazinone Derivatives as Antagonists of Inhibitor of Apoptosis Proteins (IAPs)

Hyun-Ju Park, Jisook Kim, D. Kim, 2021 .

SAR Studies of Indole-5-propanoic Acid Derivatives To Develop Novel GPR40 Agonists.

Hyun-Ju Park, Xiaodi Zhao, Dongyun Shin, 2017, ACS medicinal chemistry letters.

Roles of 14-3-3η in mitotic progression and its potential use as a therapeutic target for cancers

J. H. Lee, Hyun-Ju Park, C. Lee, 2013, Oncogene.

Development of a novel Hsp90 inhibitor NCT-50 as a potential anticancer agent for the treatment of non-small cell lung cancer

Hyun-Ju Park, Ho Jin Lee, Jihyae Ann, 2018, Scientific Reports.

Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay.

Hyun-Ju Park, C. Kim, K. Lee, 2016, Bioorganic & medicinal chemistry letters.

Novel interaction of the Z-DNA binding domain of human ADAR1 with the oncogenic c-Myc promoter G-quadruplex.

Hyun-Jin Kang, T. Le, Hyun-Ju Park, 2014, Journal of molecular biology.

Computer-aided identification of new histone deacetylase 6 selective inhibitor with anti-sepsis activity.

Hyun-Ju Park, C. Maeng, Sun-Mee Lee, 2016, European journal of medicinal chemistry.

Deguelin Analogue SH-1242 Inhibits Hsp90 Activity and Exerts Potent Anticancer Efficacy with Limited Neurotoxicity.

Jeeyeon Lee, Sonia J. Park, Hyun-Ju Park, 2016, Cancer research.

Identification of RNA pseudoknot-binding ligand that inhibits the -1 ribosomal frameshifting of SARS-coronavirus by structure-based virtual screening.

So-Jung Park, Hyun-Ju Park, Yang-Gyun Kim, 2011, Journal of the American Chemical Society.

Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer

Min Gyu Lee, Hyun-Ju Park, Jeung-Whan Han, 2019, BMC Cancer.

Identification of novel ligands for the Z-DNA binding protein by structure-based virtual screening.

Khac-Minh Thai, K. Kim, Hyun-Ju Park, 2007, Chemical & pharmaceutical bulletin.

Quality Characteristics of Tangor Jam including Fructo Oligosaccharide and Isomalto Oligosaccharide

Hyun-Ju Park, 최소례, 진현희, 2014 .

Concise syntheses of (+)-macrosphelides A and B: studies on the macro-ring closure strategy.

Jong-Wha Jung, Hyun-Ju Park, Jakyung Yoo, 2009, The Journal of organic chemistry.

Identification and Structural Analysis of New Nrf2 Activators by Mechanism‐Based Chemical Transformation of 15‐Deoxy‐Δ12, 14‐PGJ2

Jeeyeon Lee, Y. Surh, Hyun-Ju Park, 2016, Chembiochem : a European journal of chemical biology.