G. Kontopidis

发表

Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents.

Peter M Fischer, Wayne Jackson, Campbell McInnes, 2010, Chemistry & biology.

4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.

P. Fischer, G. Kontopidis, M. Hajdúch, 2006, Journal of medicinal chemistry.

Discovery of a novel family of CDK inhibitors with the program LIDAEUS: structural basis for ligand-induced disordering of the activation loop.

Su-Ying Wu, P. Taylor, D. Lane, 2003, Structure.

Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design.

Su-Ying Wu, P. Taylor, D. Lane, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Design, synthesis, biological activity and structural analysis of cyclic peptide inhibitors targeting the substrate recruitment site of cyclin-dependent kinase complexes.

P. Fischer, G. Kontopidis, C. McInnes, 2004, Organic & biomolecular chemistry.

Aqueous Solubility Enhancement for Bioassays of Insoluble Inhibitors and QSPR Analysis: A TNF-α Study

G. Melagraki, A. Afantitis, G. Kontopidis, 2018, SLAS discovery : advancing life sciences R & D.

Differential binding of inhibitors to active and inactive CDK2 provides insights for drug design.

Peter M Fischer, Darren Gibson, Campbell McInnes, 2006, Chemistry & biology.

Classical Anticytokinins Do Not Interact with Cytokinin Receptors but Inhibit Cyclin-dependent Kinases*

D. Inzé, T. Schmülling, P. Fischer, 2007, Journal of Biological Chemistry.

Catch the kinase conformer.

G. Kontopidis, C. McInnes, M. Mezna, 2006, Chemistry & biology.

Quantification of the effects of ionic strength, viscosity, and hydrophobicity on protein-ligand binding affinity.

G. Kontopidis, C. McInnes, A. I. Grigoroudis, 2014, ACS medicinal chemistry letters.

Preparation of CDK/Cyclin Inhibitor Complexes for Structural Determination.

G. Kontopidis, A. I. Grigoroudis, Asterios I. Grigoroudis, 2016, Methods in molecular biology.

Trace mineral content of conventional, organic and courtyard eggs analysed by inductively coupled plasma mass spectrometry (ICP-MS)

Ilias Kyriazakis, George Kontopidis, G. Kontopidis, 2009 .

Enzymatic and structural characterization of non-peptide ligand-cyclophilin complexes.

P. Taylor, M. Walkinshaw, G. Kontopidis, 2004, Acta crystallographica. Section D, Biological crystallography.

Variation in Trace Element Contents Among Chicken, Turkey, Duck, Goose, and Pigeon Eggs Analyzed by Inductively Coupled Plasma Mass Spectrometry (ICP-MS)

G. Kontopidis, I. Kyriazakis, A. Gavriil, 2009, Biological Trace Element Research.

The core lipocalin, bovine beta-lactoglobulin.

G. Kontopidis, L. Sawyer, 2000, Biochimica et biophysica acta.

Some physico-chemical properties of nine commercial or semi-commercial whey protein concentrates, isolates and fractions

H. Molinari, G. Kontopidis, R. Ipsen, 1999 .

The X‐ray structure of a divergent cyclophilin from the nematode parasite Brugia malayi

H. Husi, P. Taylor, M. Walkinshaw, 1998, FEBS letters.

β-Lactoglobulin improves liposome’s encapsulation properties for vitamin E delivery

G. Kontopidis, O. Gortzi, S. Lalas, 2014, Journal of liposome research.

Apparent chemical composition of nine commercial or semi-commercial whey protein concentrates, isolates and fractions

H. Molinari, G. Kontopidis, R. Ipsen, 1999 .

Invited review: beta-lactoglobulin: binding properties, structure, and function.

G. Kontopidis, C. Holt, L. Sawyer, 2004, Journal of dairy science.

Dietary Supplementation of Benzoic Acid and Essential Oil Compounds Affects Buffering Capacity of the Feeds, Performance of Turkey Poults and Their Antioxidant Status, pH in the Digestive Tract, Intestinal Microbiota and Morphology

G. Kontopidis, C. Papaneophytou, I. Pappas, 2014, Asian-Australasian journal of animal sciences.

Design, synthesis, and evaluation of 2-methyl- and 2-amino-N-aryl-4,5-dihydrothiazolo[4,5-h]quinazolin-8-amines as ring-constrained 2-anilino-4-(thiazol-5-yl)pyrimidine cyclin-dependent kinase inhibitors.

Peter M Fischer, Wayne Jackson, Campbell McInnes, 2010, Journal of medicinal chemistry.

Thermodynamic, crystallographic and computational studies of non-mammalian fatty acid binding to bovine β-Lactoglobulin.

T. Thireou, G. Kontopidis, E. Eliopoulos, 2018, International journal of biological macromolecules.

The effects of benzoic acid and essential oil compounds in combination with protease on the performance of chickens

G. Kontopidis, C. Papaneophytou, I. Giannenas, 2014 .

Invited Review: β-Lactoglobulin: Binding Properties, Structure, and Function

Lindsay Sawyer, George Kontopidis, Carl Holt, 2004 .

Determination of hardness and mechanical properties of pig claws in three Greek swine herds

G. Kontopidis, L. Leontides, S. Zaoutsos, 2021 .

Performance and antioxidant status of broiler chickens supplemented with dried mushrooms (Agaricus bisporus) in their diet.

G. Kontopidis, I. Kyriazakis, I. Pappas, 2010, Poultry science.

Statistical approaches to maximize recombinant protein expression in Escherichia coli: a general review.

George Kontopidis, G. Kontopidis, Christos P Papaneophytou, 2014, Protein expression and purification.

Structures of cyclophilin-ligand complexes.

H. Husi, P. Taylor, M. Walkinshaw, 1997, Progress in biophysics and molecular biology.

Discovery and Design of Protein Kinase Inhibitors: Targeting the Cell Cycle in Oncology

G. Kontopidis, C. McInnes, M. Mezna, 2011 .

Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors.

D. Lane, R. Jackson, D. Zheleva, 2010, Journal of medicinal chemistry.

REPLACE: A Strategy for Iterative Design of Cyclin‐Binding Groove Inhibitors

P. Fischer, G. Kontopidis, C. McInnes, 2006, Chembiochem : a European journal of chemical biology.

Citrate transport during the citric acid fermentation by Aspergillus niger

G. Kontopidis, B. Kristiansen, M. Mattey, 1995, Biotechnology Letters.

Iterative Conversion of Cyclin Binding Groove Peptides into Druglike CDK Inhibitors with Antitumor Activity

Shu Liu, G. Kontopidis, C. McInnes, 2014, Journal of medicinal chemistry.

Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)

George Kollias, Georgia Melagraki, Thomas M. Mavromoustakos, 2017, PLoS Comput. Biol..

Erratum to: “Milk protein structure—what can it tell the dairy industry?”

G. Jameson, G. Kontopidis, P. Barlow, 2002 .

The core lipocalin, bovine β-lactoglobulin.

G. Kontopidis, L. Sawyer, 2000 .

The ligand-binding site of bovine beta-lactoglobulin: evidence for a function?

Lindsay Sawyer, George Kontopidis, Carl Holt, 2002, Journal of molecular biology.

β‐Lactoglobulin – a three‐dimensional perspective

Su-Ying Wu, G. Kontopidis, L. Sawyer, 1999 .

Design and Synthesis of Type-IV Inhibitors of BRAF Kinase That Block Dimerization and Overcome Paradoxical MEK/ERK Activation.

G. Kontopidis, C. McInnes, S. Braun, 2019, Journal of medicinal chemistry.

Optimization of TNF-α overexpression in Escherichia coli using response surface methodology: Purification of the protein and oligomerization studies.

G. Kontopidis, Christos P Papaneophytou, George A Kontopidis, 2012, Protein expression and purification.

Structure-based discovery of a family of synthetic cyclophilin inhibitors showing a cyclosporin-A phenotype in Caenorhabditis elegans.

Nicholas J Turner, Paul Taylor, George Kontopidis, 2007, Biochemical and biophysical research communications.

Review Milk protein structureFwhat can it tell the dairy industry

G. Jameson, G. Kontopidis, P. Barlow, 2002 .

Milk protein structure-what can it tell the dairy industry?(vol 12, pg 299, 2002)

G. Jameson, G. Kontopidis, P. Barlow, 2002 .

In vitro and in vivo assessment of vitamin A encapsulation in a liposome–protein delivery system

G. Kontopidis, O. Gortzi, S. Lalas, 2018, Journal of liposome research.

A comparison of statistical approaches used for the optimization of soluble protein expression in Escherichia coli.

G. Kontopidis, C. Papaneophytou, 2016, Protein expression and purification.

Efficient soluble expression of active recombinant human cyclin A2 mediated by E. coli molecular chaperones.

G. Kontopidis, C. McInnes, P. N. Premnath, 2015, Protein expression and purification.

Insights into cyclin groove recognition: complex crystal structures and inhibitor design through ligand exchange.

D. Lane, M. Walkinshaw, D. Zheleva, 2003, Structure.

A statistical approach for optimization of RANKL overexpression in Escherichia coli: purification and characterization of the protein.

Eleni Douni, Vagelis Rinotas, George Kontopidis, 2013, Protein expression and purification.

The First Direct Determination of a Ligand Binding Constant in Protein Crystals.

P. Taylor, M. Walkinshaw, G. Kontopidis, 2001, Angewandte Chemie.

Development and Evaluation of a Phospholipid-sterol-protein Membrane Resembling System

G. Kontopidis, O. Gortzi, S. Lalas, 2015, Food Biophysics.

Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-α/SPD304 Study.

Eleni Douni, Vagelis Rinotas, G. Kontopidis, 2013, ACS medicinal chemistry letters.

Structural and Biochemical Characterization of the Human Angiogenin-Proliferating Cell Nuclear Antigen Interaction.

Georgios E. Papadopoulos, G. Kontopidis, D. Leonidas, 2023, Biochemistry.

Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors.

D. Lane, P. Fischer, Shudong Wang, 2004, Chemistry & biology.

Optimization of non-ATP competitive CDK/cyclin groove inhibitors through REPLACE-mediated fragment assembly.

Shu Liu, G. Kontopidis, C. McInnes, 2013, Journal of medicinal chemistry.

Studying protein–ligand interactions using protein crystallography

Malcolm D. Walkinshaw, Paul Taylor, Liam J. Worrall, 2005 .

Current Status and Future Prospects of Small-molecule Protein-protein Interaction (PPI) Inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL).

G. Kollias, G. Melagraki, A. Afantitis, 2018, Current Topics in Medicinal Chemistry.

Ovine β-lactoglobulin at atomic resolution.

G. Kontopidis, L. Sawyer, Anna Nordle Gilliver, 2014, Acta crystallographica. Section F, Structural biology communications.

Discovery of Small-Molecule Inhibitors of Receptor Activator of Nuclear Factor-κB Ligand (RANKL) with Superior Therapeutic Index.

G. Kontopidis, E. Eliopoulos, E. Douni, 2020, Journal of medicinal chemistry.

Locally Produced Agricultural By-Products as Feed Sources for Pigs

G. Kontopidis, L. Leontides, K. Katsoulis, 2016 .

Structure-Based Discovery of Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclastogenesis Inhibitors

Veroniki P. Vidali, G. Kontopidis, E. Eliopoulos, 2023, International journal of molecular sciences.

Synthesis and biological evaluation of potential small moleculeinhibitors of tumor necrosis factor

G. Kollias, G. Kontopidis, E. Eliopoulos, 2015 .

Rationally Designed Less Toxic SPD‐304 Analogs and Preliminary Evaluation of Their TNF Inhibitory Effects

George Kollias, Elias Eliopoulos, Eleni Douni, 2014, Archiv der Pharmazie.

REPLACE: A Strategy for Iterative Design of Cyclin‐Binding Groove Inhibitors

P. Fischer, G. Kontopidis, P. Jewsbury, 2006, Chembiochem : a European journal of chemical biology.

Discovery and characterization of 2-anilino-4- (thiazol-5-yl)pyrimidine transcriptional CDK inhibitors as anticancer agents.

D. Lane, R. Jackson, D. Zheleva, 2010, Chemistry & biology.

Thermodynamic, Crystallographic and Computational Studies of Non Mammalian Fatty Acid Binding to Bovine b-Lactoglobulin

G. Kontopidis, M. Rovoli, 2018 .