J. Maybaum

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Dependence of fluorodeoxyuridine-induced cytotoxicity and megabase DNA fragment formation on S phase progression in HT29 cells

T. Lawrence, Hsin-yi Tang, K. Weber, 2009, Cancer Chemotherapy and Pharmacology.

Differential chromatid damage induced by 6-thioguanine in CHO cells.

J. Maybaum, H. G. Mandel, H. Mandel, 1981, Experimental cell research.

Unilateral chromatid damage: a new basis for 6-thioguanine cytotoxicity.

J. Maybaum, H. G. Mandel, H. Mandel, 1983, Cancer research.

Death in Human Colon Cancer Cells Correlates with Premature Mitotic Entry and Clonogenic-Deoxyuridine-Induced cdc 25 A Accumulation ′ 5-Fluoro-2 Updated

J. Maybaum, L. A. Parsels, J. Parsels, 2004 .

5-Fluoro-2′-Deoxyuridine-Induced cdc25A Accumulation Correlates with Premature Mitotic Entry and Clonogenic Death in Human Colon Cancer Cells

J. Maybaum, L. A. Parsels, J. Parsels, 2004, Cancer Research.

Expression of endogenously activated secreted or cell surface carboxypeptidase A sensitizes tumor cells to methotrexate-alpha-peptide prodrugs.

A. Rehemtulla, D. Hamstra, J. Maybaum, 2000, Cancer research.

Effects of Dexamethasone or Celecoxib on Biliary Toxicity after Hepatic Arterial Infusion of 5-Fluorodeoxyuridine in a Canine Model

David A. Williams, J. Knol, J. Maybaum, 2004, Cancer Research.

Prediction of thioguanine-induced cytotoxicity by dual-parameter flow cytometric analysis

J. Maybaum, C. Rogers, P. Ting, 2004, Cancer Chemotherapy and Pharmacology.

Sensitization of Pancreatic Cancers to Gemcitabine Chemoradiation by WEE1 Kinase Inhibition Depends on Homologous Recombination Repair12

T. Lawrence, J. Maybaum, Mary A Davis, 2015, Neoplasia.

Combined Inhibition of Wee1 and PARP1/2 for Radiosensitization in Pancreatic Cancer

T. Lawrence, J. Maybaum, Mary A Davis, 2014, Clinical Cancer Research.

Selective radiosensitization of p53 mutant pancreatic cancer cells by combined inhibition of Chk1 and PARP1

T. Lawrence, J. Maybaum, M. Morgan, 2011, Cell cycle.

Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition.

T. Lawrence, J. Maybaum, S. Zabludoff, 2011, Neoplasia.

N-Nitrosodimethylamine-mediated cytotoxicity in a cell line expressing P450 2E1: evidence for apoptotic cell death.

J. Maybaum, P. Hollenberg, L. A. Parsels, 1999, Toxicology and applied pharmacology.

Role of checkpoint kinase 1 in preventing premature mitosis in response to gemcitabine.

T. Lawrence, J. Maybaum, M. Morgan, 2005, Cancer research.

The contribution of DNA replication stress marked by high-intensity, pan-nuclear γH2AX staining to chemosensitization by CHK1 and WEE1 inhibitors

Daria M. Tanska, T. Lawrence, J. Maybaum, 2018, Cell cycle.

Tissue-specific pharmacodynamics of 5-bromo-2'-deoxyuridine incorporation into DNA in VX2 tumor-bearing rabbits.

J. Wagner, J. Knol, J. Maybaum, 1988, Cancer research.

Analysis of bromodeoxyuridine incorporation into DNA: comparison of gas chromatographic/mass spectrometric, CsCl gradient sedimentation, and specific radioactivity methods.

J. Maybaum, P. Stetson, W. Ensminger, 1987, Analytical biochemistry.

Fluorodeoxyuridine-mediated cytotoxicity and radiosensitization require S phase progression.

T. Lawrence, J. Maybaum, M. Davis, 1996, International journal of radiation biology.

Resistance to fluorodeoxyuridine-induced DNA damage and cytotoxicity correlates with an elevation of deoxyuridine triphosphatase activity and failure to accumulate deoxyuridine triphosphate.

T. Lawrence, C. Canman, Hsin-yi Tang, 1993, Cancer research.

Dose Escalation Trial of the Wee1 Inhibitor Adavosertib (AZD1775) in Combination With Gemcitabine and Radiation for Patients With Locally Advanced Pancreatic Cancer.

M. Schipper, T. Lawrence, J. Maybaum, 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Cancer Therapy : Preclinical Sensitization of Pancreatic Cancer to Chemoradiation by the Chk 1 Inhibitor MK 8776

Daria M. Tanska, T. Lawrence, J. Maybaum, 2013 .

Bcl-2 inhibits chemotherapy-induced apoptosis in neuroblastoma.

C. Bloch, C. Rode, A. K. Merchant, 1994, Cancer research.

Dependence of fluorodeoxyuridine-mediated radiosensitization on S phase progression.

T. Lawrence, J. Maybaum, M. Davis, 1995, International Journal of Radiation Biology.

Dependence of 5-fluorouracil-mediated radiosensitization on DNA-directed effects.

T. Lawrence, J. Maybaum, M. Davis, 1994, International journal of radiation oncology, biology, physics.

Selective inhibition of sequence-specific protein-DNA interactions by incorporation of 6-thioguanine: cleavage by restriction endonucleases.

J. Maybaum, W. Roethel, J. Kroll, 1991, Molecular pharmacology.

In vivo rates of pyrimidine nucleotide metabolism in intact mouse T-lymphoma (s-49) cells treated with 5-fluorouracil.

W. Sadee, M. Cohen, J. Maybaum, 1981, The Journal of biological chemistry.

Variations in patterns of DNA damage induced in human colorectal tumor cells by 5-fluorodeoxyuridine: implications for mechanisms of resistance and cytotoxicity.

T. Lawrence, C. Canman, Hsin-yi Tang, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Dissociation of gemcitabine chemosensitization by CHK1 inhibition from cell cycle checkpoint abrogation and aberrant mitotic entry

Daria M. Tanska, T. Lawrence, J. Maybaum, 2016, Cell cycle.

Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells

J. Maybaum, E. Radany, L. A. Parsels, 1998, Cancer Chemotherapy and Pharmacology.

The effect of single versus double-strand substitution on halogenated pyrimidine-induced radiosensitization and DNA strand breakage in human tumor cells.

T. Lawrence, J. Maybaum, M. Davis, 1990, Radiation research.

Cytochrome c Depletion upon Expression of Bcl-XS*

A. Rehemtulla, J. Fridman, J. Maybaum, 2001, The Journal of Biological Chemistry.

Prevention of fluorodeoxyuridine-induced cytotoxicity and DNA damage in HT29 colon carcinoma cells by conditional expression of wild-type p53 phenotype.

R. Zellars, M. Clarke, T. Lawrence, 1997, Molecular pharmacology.

Enhanced cytotoxicity with methotrexate in conjunction with hypoxanthine in L1210 cells in culture

J. Maybaum, C. Fairchild, J. Straw, 2004, Cancer Chemotherapy and Pharmacology.

Concurrent unilateral chromatid damage and DNA strand breakage in response to 6-thioguanine treatment.

J. Maybaum, C. Fairchild, K. A. Kennedy, 1986, Biochemical pharmacology.

N-acetylprocainamide is a less potent inducer of T cell autoreactivity than procainamide.

S. Hanash, J. Strahler, J. Maybaum, 1988, Arthritis and rheumatism.

Expression of wild-type p53 stimulates an increase in both Bax and Bcl-xL protein content in HT29 cells.

A. K. Merchant, J. Maybaum, T. L. Loney, 1996, Oncogene.

Induction of resistance to fluorodeoxyuridine cytotoxicity and DNA damage in human tumor cells by expression of Escherichia coli deoxyuridinetriphosphatase.

T. Lawrence, C. Canman, J. Maybaum, 1994, Cancer research.

Induction of megabase DNA fragments by 5-fluorodeoxyuridine in human colorectal tumor (HT29) cells.

T. Lawrence, J. Maybaum, M. Davis, 1991, Molecular pharmacology.

bcl-X(S)-induced cell death in 3T3 cells does not require or induce caspase activation.

J. Fridman, J. Maybaum, M. Benedict, 1999, Cancer research.

bcl-XS-induced Cell Death in 3 T 3 Cells Does Not Require or Induce Caspase Activation 1

J. Fridman, J. Maybaum, M. Benedict, 1999 .

The use of biphasic linear ramped pulsed field gel electrophoresis to quantify DNA damage based on fragment size distribution.

T. Lawrence, J. Maybaum, M. Davis, 1993, International journal of radiation oncology, biology, physics.

Modulation of the cytotoxic mechanism of 6-thioguanine by 4-amino-5-imidazolecarboxamide

J. Maybaum, C. Rogers, C. Morgans, 1990, Cancer Chemotherapy and Pharmacology.

Improving Gemcitabine-mediated Radiosensitization Using Molecularly Targeted Therapy: a Review Gemcitabine Biochemistry and Radiosensitization Cellular Effects of Radiation and Gemcitabine Radiation Oncology, And

T. Lawrence, J. Maybaum, M. Morgan, 2022 .

Regulation of RNA- and DNA-directed actions of 5-fluoropyrimidines in mouse T-lymphoma (S-49) cells.

W. Sadee, J. Maybaum, J. L. Day, 1980, Cancer research.

Modulation of iododeoxyuridine-mediated radiosensitization by 5-fluorouracil in human colon cancer cells.

T. Lawrence, J. Maybaum, Mary A Davis, 1992, International journal of radiation oncology, biology, physics.

J. Maybaum, W. Roethel, H. Mandel, 1985, Biochemical Pharmacology.

Comparison of in yivo and in Vitro Effects of Continuous Exposure of LI 210 Cells to 6-Thioguanine 1

J. Maybaum, C. Morgans, L. A. Hink, 2006 .

Analysis of purine ribonucleotides and deoxyribonucleotides in cell extracts by high-performance liquid chromatography.

W. Sadee, M. Cohen, J. Maybaum, 1980, Journal of chromatography.

Determination of pyrimidine ribotide and deoxyribotide pools in cultured cells and mouse liver by high-performance liquid chromatography.

W. Sadee, J. Maybaum, F. Klein, 1980, Journal of chromatography.

Comparison of in vivo and in vitro effects of continuous exposure of L1210 cells to 6-thioguanine.

J. Maybaum, C. Morgans, L. A. Hink, 1987, Cancer research.

Guanine nucleotide depletion and toxicity in mouse T lymphoma (S-49) cells.

W. Sadee, M. Cohen, J. Maybaum, 1981, The Journal of biological chemistry.

The dependence of halogenated pyrimidine incorporation and radiosensitization on the duration of drug exposure.

T. Lawrence, T. Lawrence, J. Maybaum, 1990, International journal of radiation oncology, biology, physics.

Fluorodeoxyuridine-mediated modulation of iododeoxyuridine incorporation and radiosensitization in human colon cancer cells in vitro and in vivo.

T. Lawrence, J. Maybaum, Mary A Davis, 1991, Cancer research.

Kinetics of bromodeoxyuridine elimination from human colon cancer cells in vitro and in vivo.

T. Lawrence, J. Maybaum, M. Davis, 1994, Cancer research.

The potential superiority of bromodeoxyuridine to iododeoxyuridine as a radiation sensitizer in the treatment of colorectal cancer.

T. Lawrence, J. Maybaum, Mary A Davis, 1992, Cancer research.

Simultaneous determination of thymine and 5-bromouracil in DNA hydrolysates using gas chromatography-mass spectrometry with selected-ion monitoring.

J. Maybaum, P. Stetson, W. Ensminger, 1986, Journal of chromatography.

Inhibition of Protein Phosphatase 2A Radiosensitizes Pancreatic Cancers by Modulating CDC25C/CDK1 and Homologous Recombination Repair

T. Lawrence, Yi Sun, J. Maybaum, 2013, Clinical Cancer Research.

Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity.

S. Hanash, J. Strahler, J. Maybaum, 1988, Journal of immunology.

Escherichia coli thymidylate synthase expression protects human cells from the cytotoxic effects of 5-fluorodeoxyuridine more effectively than human thymidylate synthase overexpression

F. Maley, J. Maybaum, M. Kowalski, 2000, Cancer Gene Therapy.

Improving the efficacy of chemoradiation with targeted agents.

T. Lawrence, J. Maybaum, M. Morgan, 2014, Cancer discovery.

Sensitization of Pancreatic Cancer to Chemoradiation by the Chk1 Inhibitor MK8776

Daria M. Tanska, T. Lawrence, J. Maybaum, 2013, Clinical Cancer Research.

Gemcitabine sensitization by checkpoint kinase 1 inhibition correlates with inhibition of a Rad51 DNA damage response in pancreatic cancer cells

Jonathan Maybaum, Daria M. Tanska, Theodore S Lawrence, 2009, Molecular Cancer Therapeutics.

The Relationship of Premature Mitosis to Cytotoxicity in Response to Checkpoint Abrogation and Antimetabolite Treatment

T. Lawrence, J. Maybaum, M. Morgan, 2006, Cell cycle.

Influence of cell cycle phase on radiation-induced cytotoxicity and DNA damage in human colon cancer (HT29) and Chinese hamster ovary cells.

T. Lawrence, J. Maybaum, M. Davis, 1994, Radiation research.

The Combination of Epidermal Growth Factor Receptor Inhibitors with Gemcitabine and Radiation in Pancreatic Cancer

T. Lawrence, J. Maybaum, D. Normolle, 2008, Clinical Cancer Research.

Sensitization of pancreatic cancer stem cells to gemcitabine by Chk1 inhibition.

T. Lawrence, J. Maybaum, S. Zabludoff, 2011, Neoplasia.

Assessment of Chk1 Phosphorylation as a Pharmacodynamic Biomarker of Chk1 Inhibition

Daria M. Tanska, T. Lawrence, J. Maybaum, 2011, Clinical Cancer Research.

Wee1 Kinase Inhibitor AZD1775 Radiosensitizes Hepatocellular Carcinoma Regardless of TP53 Mutational Status Through Induction of Replication Stress.

T. Lawrence, J. Maybaum, Mary A Davis, 2016, International journal of radiation oncology, biology, physics.

Dependence of etoposide-induced cytotoxicity and topoisomerase II-mediated DNA strand breakage on the intracellular ionic environment.

T. Lawrence, C. Canman, J. Maybaum, 1989, Cancer research.

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

Jonathan Maybaum, Diane M Simeone, Theodore S Lawrence, 2010, Cancer research.

PARP1 Trapping and DNA Replication Stress Enhance Radiosensitization with Combined WEE1 and PARP Inhibitors

T. Lawrence, M. O’Connor, J. Maybaum, 2017, Molecular Cancer Research.

Effects of incorporation of 6-thioguanine into SV40 DNA.

J. Maybaum, W. Roethel, J. Kroll, 1987, Molecular pharmacology.

Bayesian Hierarchical Changepoint Methods in Modeling the Tumor Growth Profiles in Xenograft Experiments

Daniel Normolle, Jonathan Maybaum, Theodore S Lawrence, 2010, Clinical Cancer Research.

A caspase-resistant form of Bcl-X(L), but not wild type Bcl-X(L), promotes clonogenic survival after ionizing radiation.

A. Chinnaiyan, A. Rehemtulla, J. Fridman, 1999, Neoplasia.

Lack of dependence of 5-fluorodeoxyuridine-mediated radiosensitization on cytotoxicity.

T. Lawrence, C. Canman, J. Maybaum, 1995, Radiation research.

Divergent patterns of incorporation of bromodeoxyuridine and iododeoxyuridine in human colorectal tumor cell lines.

J. Maybaum, W. Ensminger, E. Burton, 1991, Biochemical pharmacology.

Improving Gemcitabine-Mediated Radiosensitization Using Molecularly Targeted Therapy: A Review

T. Lawrence, J. Maybaum, M. Morgan, 2008, Clinical Cancer Research.

Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair.

T. Lawrence, C. Canman, J. Maybaum, 2010, Cancer research.

Fluoropyrimidines as Radiation Sensitizers.

J. Maybaum, Lawrence, Maybaum, 1993, Seminars in radiation oncology.

Dynamics of Bromodeoxyuridine Incorporation into DNA of Squamous Carcinoma Cells During Mid and Late Logarithmic Growth

J. Wagner, T. Carey, J. Maybaum, 1988, Pharmaceutical Research.

Combined Inhibition of Wee1 and PARP1/2 for Radiosensitization in Pancreatic Cancer

T. Lawrence, J. Maybaum, Mary A Davis, 2014, Clinical Cancer Research.