D. Kletsas

D. Kletsas, Anastasios Kouroumalis, C. Christophoridis, 2022, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Senescence in human intervertebral discs

D. Kletsas, S. Roberts, S. Eisenstein, 2006, European Spine Journal.

Mechanical loading of the intervertebral disc: from the macroscopic to the cellular level

H. Wilke, E. Mavrogonatou, D. Kletsas, 2014, European Spine Journal.

Novel quinazolinone-based 2,4-thiazolidinedione-3-acetic acid derivatives as potent aldose reductase inhibitors.

M. Soliman, D. Kletsas, H. Pratsinis, 2017, Future medicinal chemistry.

Differential Modulation of Listeria monocytogenes Fitness, In Vitro Virulence, and Transcription of Virulence-Associated Genes in Response to the Presence of Different Microorganisms

E. Mavrogonatou, D. Kletsas, P. Skandamis, 2020, Applied and Environmental Microbiology.

Pyrimido[4,5-c]quinolin-1(2H)-ones as a novel class of antimitotic agents: Synthesis and in vitro cytotoxic activity.

D. Kletsas, H. Pratsinis, K. Metwally, 2007 .

Effects of physiological mechanical strains on the release of growth factors and the expression of differentiation marker genes in human osteoblasts growing on Ti-6Al-4V.

D. Kletsas, D. Deligianni, I. Zarkadis, 2009, Journal of biomedical materials research. Part A.

Evaluation of the antihypertensive angiotensin-converting enzyme inhibitory (ACE-I) activity and other probiotic properties of lactic acid bacteria isolated from traditional Greek dairy products

B. Devreese, E. Mavrogonatou, D. Kletsas, 2017 .

Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase.

D. Kletsas, H. Pratsinis, A. Mitschler, 2018, European journal of medicinal chemistry.

Light-cured or chemically cured orthodontic adhesive resins? A selection based on the degree of cure, monomer leaching, and cytotoxicity.

T. Eliades, C. Bourauel, D. Kletsas, 2005, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

In vitro cytostatic and immunomodulatory properties of the medicinal mushroom Lentinula edodes.

D. Kletsas, H. Pratsinis, D. Arapoglou, 2008, Phytomedicine : international journal of phytotherapy and phytopharmacology.

The role of oxidative DNA damage in radiation induced bystander effect.

D. Kletsas, V. Gorgoulis, A. Kotsinas, 2015, Cancer letters.

Phytochemical Study and In Vitro Screening Focusing on the Anti-Aging Features of Various Plants of the Greek Flora

E. Mavrogonatou, D. Kletsas, I. Trougakos, 2021, Antioxidants.

Syntheses, antiproliferative activity and theoretical characterization of acitretin-type retinoids with changes in the lipophilic part.

Dimitris Kletsas, George Maroulis, N. Karamanos, 2011, European journal of medicinal chemistry.

Imatinib Mesylate Inhibits Proliferation and Exerts an Antifibrotic Effect in Human Breast Stroma Fibroblasts

N. Karamanos, G. Voutsinas, D. Kletsas, 2008, Molecular Cancer Research.

Purine 5′,8-cyclo-2′-deoxynucleoside lesions: formation by radical stress and repair in human breast epithelial cancer cells

D. Kletsas, K. Papadopoulos, Michael A. Terzidis, 2017, Free radical research.

Differential proliferative response of fetal and adult human skin fibroblasts to transforming growth factor‐β

D. Kletsas, H. Pratsinis, S. Psarras, 2004, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

Immunocytochemical evidence of PDGF- and TGF-β-like molecules in invertebrate and vertebrate immunocytes: An evolutionary approach

D. Kletsas, E. Ottaviani, A. Franchini, 1996, The Histochemical Journal.

Cell sources for nucleus pulposus regeneration

M. Fröhlich, J. Urban, D. Kletsas, 2014, European Spine Journal.

Grape stem extracts: Polyphenolic content and assessment of their in vitro antioxidant properties

D. Kletsas, A. Skaltsounis, H. Pratsinis, 2012 .

Chronic in vivo exposure to glucocorticoids prolongs cellular lifespan: the case of Cushing's syndrome-patients' fibroblasts

D. Kletsas, H. Pratsinis, S. Tsagarakis, 2002, Experimental Gerontology.

Editorial: Wound healing and fibrosis—two sides of the same coin

D. Kletsas, T. Pihlajaniemi, D. Gullberg, 2016, Cell and Tissue Research.

Aging of Fibroblasts

D. Kletsas, 2003 .

Down-Regulation of the Proteoglycan Decorin Fills in the Tumor-Promoting Phenotype of Ionizing Radiation-Induced Senescent Human Breast Stromal Fibroblasts

E. Mavrogonatou, D. Kletsas, H. Pratsinis, 2021, Cancers.

Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β

N. Karamanos, E. Mavrogonatou, D. Kletsas, 2016, Aging.

Human lung fibroblasts prematurely senescent after exposure to ionizing radiation enhance the growth of malignant lung epithelial cells in vitro and in vivo.

D. Kletsas, A. Papadopoulou, 2011, International journal of oncology.

In Vitro Virulence Potential, Surface Attachment, and Transcriptional Response of Sublethally Injured Listeria monocytogenes following Exposure to Peracetic Acid

E. Mavrogonatou, D. Kletsas, P. Skandamis, 2021, Applied and environmental microbiology.

The effect of triethylene glycol dimethacrylate on p53-dependent G2 arrest in human gingival fibroblasts.

T. Eliades, E. Mavrogonatou, D. Kletsas, 2010, Biomaterials.

Growth hormone/JAK‐STAT axis signal‐transduction defect

A. Papavassiliou, D. Kletsas, T. Alexandrides, 2006, The FEBS journal.

Growth hormone/JAK-STAT axis signal-transduction

A. Papavassiliou, D. Kletsas, T. Alexandrides, 2006 .

Listeria monocytogenes Strains Underrepresented during Selective Enrichment with an ISO Method Might Dominate during Passage through Simulated Gastric Fluid and In Vitro Infection of Caco-2 Cells

E. Mavrogonatou, D. Kletsas, P. Skandamis, 2016, Applied and Environmental Microbiology.

STI571 as a potent inhibitor of growth and invasiveness of human epithelial breast cancer cells.

A. Theocharis, N. Karamanos, D. Kletsas, 2004, Anticancer research.

Long-term exposure to TNF-α leads human skin fibroblasts to a p38 MAPK- and ROS-mediated premature senescence

E. Mavrogonatou, D. Kletsas, Angeliki Konstantinou, 2018, Biogerontology.

Interactions of signaling pathways in ACTH (1–24)-induced cell shape changes in invertebrate immunocytes

D. Kletsas, E. Ottaviani, D. Sassi, 1998, Peptides.

Stimulation of human embryonic lung fibroblasts by TGF‐β and PDGF acting in synergism. The role of Cell Density.

D. Kletsas, S. Psarras, D. Stathakos, 1993, Cell biology international.

Oleuropein is a Powerful Sensitizer of Doxorubicin-mediated Killing of Prostate Cancer Cells and Exerts Its Action via Induction of Autophagy

D. Kletsas, D. Benaki, A. Papachristodoulou, 2018 .

Antiproliferative Effects of Red and White Wine Extracts in PC-3 Prostate Cancer Cells

D. Kletsas, M. Xanthopoulou, H. Pratsinis, 2017, Nutrition and cancer.

Galectin-3 interferes with tissue repair and promotes cardiac dysfunction and comorbidities in a genetic heart failure model

D. Kletsas, H. Pratsinis, Y. Capetanaki, 2022, Cellular and Molecular Life Sciences.

Optimized synthesis of novel prenyl ferulate performed by feruloyl esterases from Myceliophthora thermophila in microemulsions

D. Kletsas, U. Rova, P. Christakopoulos, 2017, Applied Microbiology and Biotechnology.

Decreased differentiation capacity and altered expression of extracellular matrix components in irradiation‐mediated senescent human breast adipose‐derived stem cells

E. Mavrogonatou, D. Kletsas, H. Pratsinis, 2022, IUBMB life.

Effect of hyperglycaemic conditions on the response of human periodontal ligament fibroblasts to mechanical stretching.

T. Eliades, D. Kletsas, A. Papadopoulou, 2019, European journal of orthodontics.

Phytochemical Analysis and Antioxidant Potential of the Phytonutrient-Rich Decoction of Cichorium spinosum and C. intybus

D. Kletsas, H. Pratsinis, M. Halabalaki, 2016, Planta Medica.

Oestrogenicity of orthodontic adhesive resins.

T. Eliades, D. Kletsas, G. Eliades, 2007, European journal of orthodontics.

The antimitotic pyrimido[4,5-c]quinolin-1(2H)-one scaffold: probing substituents at position 3

D. Kletsas, H. Pratsinis, K. Metwally, 2015, Medicinal Chemistry Research.

Three-dimensional (3D) hierarchical oxygen plasma micro/nanostructured polymeric substrates for selective enrichment of cancer cells from mixtures with normal ones.

E. Gogolides, D. Kletsas, M. Chatzichristidi, 2019, Colloids and surfaces. B, Biointerfaces.

Restoration of down-regulated PDGF receptors by TGF-beta in human embryonic fibroblasts. Enhanced response during cellular in vitro aging.

D. Kletsas, S. Psarras, D. Stathakos, 1994, FEBS letters.

Presence and role of cytokines and growth factors in invertebrates

C. Franceschi, D. Kletsas, E. Ottaviani, 1996 .

In Vitro Assessment of Cytotoxicity and Estrogenicity of Vivera® Retainers.

T. Eliades, D. Kletsas, H. Pratsinis, 2018, The journal of contemporary dental practice.

Activation of the JNKs/ATM-p53 axis is indispensable for the cytoprotection of dermal fibroblasts exposed to UVB radiation

E. Mavrogonatou, D. Kletsas, V. Gorgoulis, 2022, Cell Death & Disease.

Growth Factors in Intervertebral Disc Homeostasis

D. Kletsas, H. Pratsinis, 2008, Connective tissue research.

Neutral endopeptidase-24.11 (NEP) activity in human fibroblasts during development and ageing

C. Franceschi, D. Kletsas, E. Ottaviani, 1998, Mechanisms of Ageing and Development.

Assessment of telomerase activity in leukocytes of type 2 diabetes mellitus patients having or not foot ulcer: Possible correlation with other clinical parameters

D. Spandidos, M. Roustit, M. Grammatikopoulou, 2018, Experimental and therapeutic medicine.

In Vitro Assay Systems for the Assessment of Oestrogenicity

D. Kletsas, H. Pratsinis, 2014 .

Rhinovirus-induced basic fibroblast growth factor release mediates airway remodeling features

N. Papadopoulos, S. Johnston, D. Kletsas, 2012, Clinical and Translational Allergy.

Ageing research in Greece

Nektarios Tavernarakis, G. Panayotou, D. Kletsas, 2002, Experimental Gerontology.

Differential effects of clusterin/apolipoprotein J on cellular growth and survival.

D. Kletsas, I. Trougakos, E. Gonos, 2005, Free radical biology & medicine.

Genetic variants of interleukin 1B and 6 are associated with clinical outcome of surgically treated lumbar degenerative disc disease

J. Kaprio, M. Battié, D. Kletsas, 2022, BMC Musculoskeletal Disorders.

Quiescence and proliferative response of normal human embryonic fibroblasts in homologous environment. Effect of aging.

D. Kletsas, D. Stathakos, 1992, Cell biology international reports.

Cyclic tensile stress of human annulus fibrosus cells induces MAPK activation: involvement in proinflammatory gene expression.

D. Kletsas, H. Pratsinis, C. Neidlinger-Wilke, 2016, Osteoarthritis and cartilage.

Fibroblast Responses to Exogenous and Autocrine Growth Factors Relevant to Tissue Repair: The Effect of Aging

D. Kletsas, H. Pratsinis, E. Ottaviani, 2000, Annals of the New York Academy of Sciences.

The growth-inhibitory block of TGF-beta is located close to the G1/S border in the cell cycle.

D. Kletsas, L. Philipson, V. Sorrentino, 1995, Experimental cell research.

Developmental and age-related alterations of calcium homeostasis in human fibroblasts

D. Kletsas, P. Papazafiri, 2003, Experimental Gerontology.

Short- and long-term treatment with TNF-α inhibits the induction of osteoblastic differentiation in cyclic tensile-stretched periodontal ligament fibroblasts.

T. Eliades, D. Kletsas, D. Koletsi, 2020, European journal of orthodontics.

Autocrine growth regulation in fetal and adult human fibroblasts.

D. Kletsas, H. Pratsinis, D. Stathakos, 1997, Biochemical and biophysical research communications.

Probiotic Features of Lactic Acid Bacteria Isolated from a Diverse Pool of Traditional Greek Dairy Products Regarding Specific Strain-Host Interactions

E. Mavrogonatou, D. Kletsas, M. Kazou, 2018, Probiotics and Antimicrobial Proteins.

Human nucleus pulposus intervertebral disc cells becoming senescent using different treatments exhibit a similar transcriptional profile of catabolic and inflammatory genes

E. Mavrogonatou, D. Kletsas, Sotiris-Spyros Vamvakas, 2017, European Spine Journal.

Adhesion, Viability and Differentiation of Adipose Tissue Derived Mesenchymal Stem Cells onto Micro/Nanostructured Polystyrene Substrates

E. Gogolides, E. Mavrogonatou, D. Kletsas, 2022, Proceedings of the 7th World Congress on Recent Advances in Nanotechnology.

Reacquisition of a spindle cell shape does not lead to the restoration of a youthful state in senescent human skin fibroblasts

D. Kletsas, P. Petrou, S. Kakabakos, 2020, Biogerontology.

Imetelstat (a telomerase antagonist) exerts off-target effects on the cytoskeleton

J. Shay, D. Kletsas, A. Can, 2013, International journal of oncology.

PDGF and TGF-beta partially prevent 2-deoxy-D-ribose-induced apoptosis in the fat body cell line IPLB-LdFB from the insect Lymantria dispar.

D. Kletsas, E. Ottaviani, D. Barbieri, 2000, Journal of insect physiology.

Senescent human periodontal ligament fibroblasts after replicative exhaustion or ionizing radiation have a decreased capacity towards osteoblastic differentiation

M. Makou, T. Eliades, D. Kletsas, 2013, Biogerontology.

PDGF and TGF-beta induce cell shape changes in invertebrate immunocytes via specific cell surface receptors.

D. Kletsas, E. Ottaviani, D. Sassi, 1998, European journal of cell biology.

Pyrimido[4,5-c]quinolin-1(2H)-ones as a novel class of antimitotic agents: Synthesis and in vitro cytotoxic activity.

D. Kletsas, H. Pratsinis, K. Metwally, 2007, European journal of medicinal chemistry.

The impact of chronic in vivo glucocorticoid excess on the functional characteristics of human skin fibroblasts obtained from patients with endogenous Cushing's syndrome.

D. Kletsas, H. Pratsinis, N. Karavitaki, 2005, European journal of endocrinology.

Food-dependent androgen and cortisol secretion by a gastric inhibitory polypeptide-receptor expressive adrenocortical adenoma leading to hirsutism and subclinical Cushing's syndrome: in vivo and in vitro studies.

C. Tsigos, D. Kletsas, S. Raptis, 2001, The Journal of clinical endocrinology and metabolism.

Prior Chronic in Vivo Glucocorticoid Excess Leads to an Anabolic Phenotype and an Extension of Cellular Life Span of Skin Fibroblasts in Vitro

D. Kletsas, H. Pratsinis, S. Tsagarakis, 2007, Annals of the New York Academy of Sciences.

The Unexpected Anabolic Phenotype and Extended Longevity of Skin Fibroblasts after Chronic Glucocorticoid Excess

D. Kletsas, H. Pratsinis, S. Tsagarakis, 2006, Dose-response : a publication of International Hormesis Society.

Senescent cells in the intervertebral disc: numbers and mechanisms.

D. Kletsas, 2009, The spine journal : official journal of the North American Spine Society.

Mesenchymal stromal cells derived from whole human umbilical cord exhibit similar properties to those derived from Wharton's jelly and bone marrow

E. Mavrogonatou, D. Kletsas, S. Roberts, 2016, FEBS open bio.

Identification of Novel Circular RNAs of the Human Protein Arginine Methyltransferase 1 (PRMT1) Gene, Expressed in Breast Cancer Cells

A. Scorilas, D. Kletsas, C. Kontos, 2022, Genes.

Screening of Panamanian Plants for Cosmetic Properties, and HPLC-Based Identification of Constituents with Antioxidant and UV-B Protecting Activities

Mahabir P. Gupta, D. Kletsas, A. Skaltsounis, 2014, Scientia pharmaceutica.

Proliferation assessment of primary human mesenchymal stem cells on collagen membranes for guided bone regeneration.

D. Kletsas, A. Humpe, P. Warnke, 2011, The International Journal of Oral and Maxillofacial Implants.

Peripheral-type benzodiazepine receptor (PBR) and PBR drug ligands in fibroblast and fibrosarcoma cell proliferation: role of ERK, c-Jun and ligand-activated PBR-independent pathways.

Dimitris Kletsas, V. Papadopoulos, D. Kletsas, 2004, Biochemical pharmacology.

Evaluating the probiotic potential and technological characteristics of yeasts implicated in cv. Kalamata natural black olive fermentation.

G. Nychas, Efstathios Z Panagou, E. Mavrogonatou, 2018, International journal of food microbiology.

Chemical and Biological Investigation of Olive Mill Waste Water – OMWW Secoiridoid Lactones

Dimitris Kletsas, Maria Halabalaki, Konstantina Vougogiannopoulou, 2015, Planta Medica.

Multiple functions of gingival and mucoperiosteal fibroblasts in oral wound healing and repair.

D. Kletsas, M. Chiquet, C. Katsaros, 2015, Periodontology 2000.

Comparative and morphofunctional studies on mytilus galloprovincialis hemocytes: Presence of two aging‐related hemocyte stages

D. Kletsas, E. Ottaviani, D. Barbieri, 1998 .

Design, synthesis and antiproliferative activity of some new azapyranoxanthenone aminoderivatives.

D. Kletsas, H. Pratsinis, P. Marakos, 2006, European journal of medicinal chemistry.

Design, Synthesis and Antiproliferative Activity of Some New Azapyranoxanthenone Amino Derivatives.

D. Kletsas, H. Pratsinis, P. Marakos, 2006 .

New bioactive 5-arylcarboximidamidopyrazolo[3,4-c]pyridines: Synthesis, cytotoxic activity, mechanistic investigation and structure-activity relationships.

D. Kletsas, H. Pratsinis, N. Lougiakis, 2021, European journal of medicinal chemistry.

Design, synthesis, and cytotoxic activity evaluation of new linear pyranoxanthone aminoderivatives

D. Kletsas, H. Pratsinis, P. Marakos, 2011 .

Synthesis and cytotoxic activity of some new azapyranoxanthenone aminoderivatives.

D. Kletsas, H. Pratsinis, P. Marakos, 2003, Bioorganic & medicinal chemistry.

Design and synthesis of novel amino-substituted xanthenones and benzo[b]xanthenones: Evaluation of their antiproliferative activity and their ability to overcome multidrug resistance toward MES-SA/D × 5 cells

D. Kletsas, A. Skaltsounis, H. Pratsinis, 2006 .

Novel polycarboxylated EDTA-type cyclodextrins as ligands for lanthanide binding: study of their luminescence, relaxivity properties of Gd(iii) complexes, and PM3 theoretical calculations.

D. Kletsas, M. Fardis, H. Pratsinis, 2010, Organic & biomolecular chemistry.

Exogenous and autocrine growth factors stimulate human intervertebral disc cell proliferation via the ERK and Akt pathways

D. Kletsas, K. Pavlakis, H. Pratsinis, 2012, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Bioactive non-coloured polyphenols content of grapes, wines and vinification by-products: evaluation of the antioxidant activities of their extracts.

D. Kletsas, A. Skaltsounis, H. Pratsinis, 2010 .

Special Issue “Anti-Aging Properties of Natural Compounds”

D. Kletsas, H. Pratsinis, 2019, Cosmetics.

Characterization and cytotoxicity of ions released from stainless steel and nickel-titanium orthodontic alloys.

M. Makou, T. Eliades, D. Kletsas, 2004, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

Human fibroblast alterations induced by low power laser irradiation at the single cell level using confocal microscopy

Dimitris Kletsas, Eleni Alexandratou, Dido Yova, 2002, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Development of anti-ageing natural products based on biodiversity of the Greek flora by employing environmentally friendly technologies and anti-ageing biological research

D. Kletsas, I. Trougakos, A. Skaltsounis, 2015 .

Scarless wound healing: From development to senescence.

E. Mavrogonatou, D. Kletsas, H. Pratsinis, 2019, Advanced drug delivery reviews.

Effect of blue light on the proliferation of human gingival fibroblasts.

T. Eliades, E. Mavrogonatou, D. Kletsas, 2008, Dental materials : official publication of the Academy of Dental Materials.

Characterization and in vitro estrogenicity of orthodontic adhesive particulates produced by simulated debonding.

T. Eliades, D. Kletsas, H. Pratsinis, 2009, Dental materials : official publication of the Academy of Dental Materials.

Cytotoxicity and estrogenicity of Invisalign appliances.

Dimitris Kletsas, Theodore Eliades, George Eliades, 2009, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

The catabolic effect of TNFα on bovine nucleus pulposus intervertebral disc cells and the restraining role of glucosamine sulfate in the TNFα‐mediated up‐regulation of MMP‐3

E. Mavrogonatou, D. Kletsas, M. Angelopoulou, 2014, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Differential response of nucleus pulposus intervertebral disc cells to high salt, sorbitol, and urea

E. Mavrogonatou, D. Kletsas, 2012, Journal of cellular physiology.

Antiproliferative activity of Greek propolis.

D. Kletsas, H. Pratsinis, I. Chinou, 2010, Journal of medicinal food.

INVOLVEMENT OF PI 3‐KINASE, PKA AND PKC IN PDGF‐ AND TGF‐β‐MEDIATED PREVENTION OF 2‐DEOXY‐D‐RIBOSE‐INDUCED APOPTOSIS IN THE INSECT CELL LINE, IPLB‐LdFB

D. Kletsas, E. Ottaviani, D. Barbieri, 2001, Cell biology international.

LIST OF ABBREVIATIONS AF : Annulus Fibrosus ADAMTS : A Disintegrin And Metalloproteinase with Thrombospondin Motifs

D. Kletsas, M. Risbud, J. Hoyland, 2016 .

Deregulated expression of c-mos in non-small cell lung carcinomas: relationship with p53 status, genomic instability, and tumor kinetics.

V. Zoumpourlis, D. Kletsas, V. Gorgoulis, 2001, Cancer research.

Platelet-derived growth factor and transforming growth factor-beta in invertebrate immune and neuroendocrine interactions: another sign of conservation in evolution.

D. Kletsas, E. Ottaviani, A. Franchini, 2001, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

NEUTRAL ENDOPEPTIDASE‐24.11 (NEP) DEACTIVATES PDGF‐ AND TGF‐β‐INDUCED CELL SHAPE CHANGES IN INVERTEBRATE IMMUNOCYTES

D. Kletsas, E. Ottaviani, E. Caselgrandi, 2000, Cell biology international.

Growth Factors and Ageing

D. Kletsas, S. Psarras, D. Stathakos, 1996 .

Intracellular Clusterin Inhibits Mitochondrial Apoptosis by Suppressing p53-Activating Stress Signals and Stabilizing the Cytosolic Ku70-Bax Protein Complex

L. Margaritis, D. Kletsas, D. Boothman, 2009, Clinical Cancer Research.

Serglycin activates pro-tumorigenic signaling and controls glioblastoma cell stemness, differentiation and invasive potential

A. Moustakas, A. Theocharis, D. Kletsas, 2020, Matrix biology plus.

Mechanical stress induces DNA synthesis in PDL fibroblasts by a mechanism unrelated to autocrine growth factor action

A. Papavassiliou, D. Kletsas, E. Basdra, 1998, FEBS letters.

PDGF, bFGF and IGF-I stimulate the proliferation of intervertebral disc cells in vitro via the activation of the ERK and Akt signaling pathways

D. Kletsas, H. Pratsinis, 2007, European Spine Journal.

Effect of varying osmotic conditions on the response of bovine nucleus pulposus cells to growth factors and the activation of the ERK and Akt pathways

E. Mavrogonatou, D. Kletsas, 2010, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

J. Bartek, W. Gu, J. Bártková, 2013, Nature Cell Biology.

Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior.

Dimitris Kletsas, Jiri Bartek, Vassilis G Gorgoulis, 2007, Cancer research.

Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis.

E. Mavrogonatou, D. Kletsas, H. Pratsinis, 2017, Matrix biology : journal of the International Society for Matrix Biology.

The Bone-specific Transcriptional Regulator Cbfa1 Is a Target of Mechanical Signals in Osteoblastic Cells*

Dimitris Kletsas, Efthimia K Basdra, A. Papavassiliou, 2002, The Journal of Biological Chemistry.

Imatinib inhibits colorectal cancer cell growth and suppresses stromal‐induced growth stimulation, MT1‐MMP expression and pro‐MMP2 activation

D. Mavroudis, D. Kletsas, G. Chalkiadakis, 2007, International journal of cancer.

Transcription factor E2F‐1 acts as a growth‐promoting factor and is associated with adverse prognosis in non‐small cell lung carcinomas

A. Papavassiliou, D. Kletsas, V. Gorgoulis, 2002, The Journal of pathology.

Estrogen receptor beta modulates breast cancer cells functional properties, signaling and expression of matrix molecules.

M. Franchi, A. Theocharis, D. Kletsas, 2016, Matrix biology : journal of the International Society for Matrix Biology.

The role of senescence in cancer development.

E. Mavrogonatou, D. Kletsas, H. Pratsinis, 2020, Seminars in cancer biology.

Relationship of the K-ras/c-mos Expression Patterns With Angiogenesis in Non-Small Cell Lung Carcinomas

A. Papavassiliou, K. Gatter, D. Kletsas, 2001, Molecular medicine.

Relationship of the Kras / cmos Expression Patterns With Angiogenesis in Non-Small Cell Lung Carcinomas

A. Papavassiliou, K. Gatter, D. Kletsas, 2001 .

Resveratrol and related stilbenes: their anti-aging and anti-angiogenic properties.

D. Kletsas, H. Pratsinis, S. Haroutounian, 2013, Food and Chemical Toxicology.

Cellular Senescence and Cancer Development: Antagonistic and Synergistic Relations

D. Kletsas, 2012 .

Long-term exposure to TNF-α leads human skin fibroblasts to a p38 MAPK- and ROS-mediated premature senescence

E. Mavrogonatou, D. Kletsas, Angeliki Konstantinou, 2018, Biogerontology.

Senescent human periodontal ligament fibroblasts after replicative exhaustion or ionizing radiation have a decreased capacity towards osteoblastic differentiation

M. Makou, T. Eliades, D. Kletsas, 2013, Biogerontology.

Robust, universal biomarker assay to detect senescent cells in biological specimens

Dimitris Kletsas, Jiri Bartek, Manuel Serrano, 2016, Aging cell.

Early responses of human periodontal ligament fibroblasts to cyclic and static mechanical stretching

T. Eliades, D. Kletsas, A. Iliadi, 2016, European journal of orthodontics.

The role of cellular senescence on the cyclic stretching-mediated activation of MAPK and ALP expression and activity in human periodontal ligament fibroblasts

M. Makou, T. Eliades, D. Kletsas, 2014, Experimental Gerontology.

p53-Dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions

A. Papavassiliou, C. Demoliou, D. Kletsas, 2005, Laboratory Investigation.

Effect of protein kinase inhibitors on the stretch‐elicited c‐Fos and c‐Jun up‐regulation in human PDL osteoblast‐like cells

A. Papavassiliou, D. Kletsas, E. Basdra, 2002, Journal of cellular physiology.

Previous chronic exogenous glucocorticoid administration in vivo does not affect functional characteristics and cellular lifespan of human skin fibroblasts in vitro

D. Kletsas, H. Pratsinis, A. Dimozi, 2011, Experimental dermatology.

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

Dimitris Kletsas, Konstantinos Vougas, Jiri Bartek, 2016, Nature Cell Biology.

Protracted p53-independent stimulation of p21 fuels genomic instability by deregulating the replication licensing machinery

Emanuel, S. Gagos, I. Roninson, 2016 .

p53, p21(WAF1/CIP1), and MDM2 involvement in the proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells.

A. Hughes, J. Hsieh, D. Kletsas, 2000, Arteriosclerosis, thrombosis, and vascular biology.

p 53 , p 21 WAF 1 / CIP 1 , and MDM 2 Involvement in the Proliferation and Apoptosis in an In Vitro Model of Conditionally Immortalized Human Vascular Smooth Muscle Cells

A. Hughes, J. Hsieh, D. Kletsas, 2000 .

IGF-I/EGF and E2 signaling crosstalk through IGF-IR conduit point affects breast cancer cell adhesion.

D. Kletsas, G. Tzanakakis, D. Nikitovic, 2016, Matrix biology : journal of the International Society for Matrix Biology.

Acid Tolerance of Streptococcus macedonicus as Assessed by Flow Cytometry and Single-Cell Sorting

D. Kletsas, H. Pratsinis, E. Tsakalidou, 2006, Applied and Environmental Microbiology.

Rapid assessment of the physiological status of Streptococcus macedonicus by flow cytometry and fluorescence probes.

D. Kletsas, H. Pratsinis, E. Tsakalidou, 2006, International journal of food microbiology.

Imatinib as a key inhibitor of the platelet‐derived growth factor receptor mediated expression of cell surface heparan sulfate proteoglycans and functional properties of breast cancer cells

C. Gialeli, D. Kletsas, G. Tzanakakis, 2013, The FEBS journal.

Preclinical evaluation of zoledronate using an in vitro mimetic cellular model for breast cancer metastatic bone disease.

C. Gialeli, A. Theocharis, D. Kletsas, 2013, Biochimica et biophysica acta.

Analysis of Env RNA expression in lung and airways

M. Herlyn, T. Halazonetis, D. Kletsas, 2011 .

Editorial: Wound healing and fibrosis—two sides of the same coin

D. Kletsas, T. Pihlajaniemi, D. Gullberg, 2016, Cell and Tissue Research.

Synthesis, in‐vitro Cytotoxicity, and a Preliminary Structure‐Activity Relationship Investigation of Pyrimido[4,5‐c]quinolin‐1(2H)‐ones

D. Kletsas, H. Pratsinis, A. Khalil, 2010, Archiv der Pharmazie.

Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome.

S. Werner, P. Angel, E. Mavrogonatou, 2018, Developmental cell.

Growth factors in fetal and adult wound healing

D. Kletsas, H. Pratsinis, 2016 .

Response of Fetal and Adult Cells to Growth Factors

D. Kletsas, H. Pratsinis, Andreas A. Armatas, 2013 .

p53 activates ICAM‐1 (CD54) expression in an NF‐κB‐independent manner

A. Papavassiliou, K. Ryan, D. Kletsas, 2003 .

EGF/EGFR signaling axis is a significant regulator of the proteasome expression and activity in colon cancer cells

Maria-Ioanna Ellina, Panagiotis Bouris, Dimitris Kletsas, 2014 .

In Vitro Assessment of Biocompatibility for Orthodontic Materials

E. Mavrogonatou, D. Kletsas, H. Pratsinis, 2013 .

Expression of matrix macromolecules and functional properties of breast cancer cells are modulated by the bisphosphonate zoledronic acid.

C. Gialeli, A. Theocharis, D. Kletsas, 2012, Biochimica et biophysica acta.

Compromise in mRNA processing machinery in senescent human fibroblasts: implications for a novel potential role of Phospho-ATR (ser428)

G. Panayotou, D. Kletsas, P. Chandris, 2010, Biogerontology.

Monitoring Autophagy Immunohistochemically and Ultrastructurally during Human Head and Neck Carcinogenesis. Relationship with the DNA Damage Response Pathway †

E. Mavrogonatou, D. Kletsas, V. Gorgoulis, 2017, International journal of molecular sciences.

Applying Broadband Dielectric Spectroscopy (BDS) for the Biophysical Characterization of Mammalian Tissues under a Variety of Cellular Stresses

N. Kostomitsopoulos, L. Margaritis, D. Kletsas, 2017, International journal of molecular sciences.

PDGF/PDGFR signaling and targeting in cancer growth and progression: Focus on tumor microenvironment and cancer-associated fibroblasts.

C. Gialeli, A. Theocharis, D. Kletsas, 2014, Current pharmaceutical design.

Paracrine anti‐fibrotic effects of neonatal cells and living cell constructs on young and senescent human dermal fibroblasts

D. Kletsas, P. Vassiliu, H. Pratsinis, 2013, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

The highly reducing sugar 2-deoxy-D-ribose induces apoptosis in human fibroblasts by reduced glutathione depletion and cytoskeletal disruption.

C. Franceschi, D. Kletsas, D. Monti, 1998, Biochemical and biophysical research communications.

Human amniotic fluid stimulates the proliferation of human fetal and adult skin fibroblasts: The roles of bFGF and PDGF and of the ERK and Akt signaling pathways

D. Kletsas, H. Pratsinis, V. Velissariou, 2010, Wound Repair and Regeneration.

Autocrine regulation of proliferation and extracellular matrix homeostasis in human fibroblasts.

D. Kletsas, I. Zervolea, D. Stathakos, 2000, Biochemical and biophysical research communications.

The Complement Inhibitor CD 59 and the Lymphocyte Function-associated Antigen-3 ( LFA-3 , CD 58 ) Genes Possess Functional Binding Sites for the p 53 Tumor Suppressor Protein

M. Gazouli, D. Kletsas, V. Gorgoulis, 2008 .

The complement inhibitor CD59 and the lymphocyte function-associated antigen-3 (LFA-3, CD58) genes possess functional binding sites for the p53 tumor suppressor protein.

M. Gazouli, D. Kletsas, V. Gorgoulis, 2002, Anticancer research.

TGF-β in Development and Ageing

E. Mavrogonatou, D. Kletsas, H. Pratsinis, 2017 .

A Novel in Vitro Model of Conditionally Immortalized Human Vascular Smooth Muscle Cells: A Tool for Aging Studies

Alun D. Hughes, D. Kletsas, H. Pratsinis, 2000, Annals of the New York Academy of Sciences.

Letrozole as a potent inhibitor of cell proliferation and expression of metalloproteinases (MMP‐2 and MMP‐9) by human epithelial breast cancer cells

D. Kletsas, H. Kalofonos, G. Tzanakakis, 2003, International journal of cancer.

Chemical, mechanical and biological properties of contemporary composite surface sealers.

D. Kletsas, N. Silikas, G. Eliades, 2015, Dental materials : official publication of the Academy of Dental Materials.

Design, synthesis, and antiproliferative activity of some novel aminosubstituted xanthenones, able to overcome multidrug resistance toward MES-SA/Dx5 cells.

D. Kletsas, A. Skaltsounis, H. Pratsinis, 2005, Bioorganic & medicinal chemistry letters.

Dynamic interplay between breast cancer cells and normal endothelium mediates the expression of matrix macromolecules, proteasome activity and functional properties of endothelial cells.

C. Gialeli, D. Kletsas, M. Viola, 2014, Biochimica et biophysica acta.

Deficiency in the α1 subunit of Na+/K+‐ATPase Enhances the Anti‐Proliferative Effect of High Osmolality in Nucleus Pulposus Intervertebral Disc Cells

V. Papadopoulos, E. Mavrogonatou, D. Kletsas, 2015, Journal of cellular physiology.

p53 activates ICAM-1 (CD54) expression in an NF-kappaB-independent manner.

A. Papavassiliou, K. Ryan, D. Kletsas, 2003, The EMBO journal.

The Effect of Glucosamine Sulfate on the Proliferative Potential and Glycosaminoglycan Synthesis of Nucleus Pulposus Intervertebral Disc Cells

E. Mavrogonatou, D. Kletsas, 2013, Spine.

Expression of matrix macromolecules and functional properties of EGF-responsive colon cancer cells are inhibited by panitumumab

C. Gialeli, A. Theocharis, D. Kletsas, 2013, Investigational New Drugs.

Low Levels of p27 in Association With Deregulated p53-pRb Protein Status Enhance Tumor Proliferation and Chromosomal Instability in Non-Small Cell Lung Carcinomas

A. Papavassiliou, D. Kletsas, V. Gorgoulis, 2001, Molecular medicine.

Estradiol–estrogen receptor: A key interplay of the expression of syndecan‐2 and metalloproteinase‐9 in breast cancer cells

A. Theocharis, D. Kletsas, G. Tzanakakis, 2008, Molecular oncology.

Cytotoxicity and estrogenicity of a novel 3-dimensional printed orthodontic aligner.

Nearchos C. Panayi, D. Kletsas, H. Pratsinis, 2022, American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics.

Evaluation of claspin as a proliferation marker in human cancer and normal tissues

D. Kletsas, M. Venere, C. Kittas, 2007, The Journal of pathology.

Expression of matrix metalloproteinase-1 (MMP-1) in Wistar rat's intervertebral disc after experimentally induced scoliotic deformity

D. Kletsas, L. Khaldi, T. Grivas, 2011, Scoliosis.

Synthesis and anticancer activity of novel quinazolinone-based rhodanines

D. Kletsas, H. Pratsinis, K. Metwally, 2017, Chemistry Central Journal.

Novel 2,4- thiazolidinediones: Synthesis, in vitro cytotoxic activity, and mechanistic investigation.

D. Kletsas, H. Pratsinis, K. Metwally, 2017, European journal of medicinal chemistry.

Mesenchymal stromal cells derived from whole human umbilical cord exhibit similar properties to those derived from Whartons jelly and bone marrow

E. Mavrogonatou, D. Kletsas, S. Roberts, 2016 .

Structure–activity relationship investigation of methoxy substitution on anticancer pyrimido[4,5-c]quinolin-1(2H)-ones

D. Kletsas, H. Pratsinis, Asmaa A. Sallam, 2013, Medicinal Chemistry Research.

Optimization of enzymatic synthesis of l-arabinose ferulate catalyzed by feruloyl esterases from Myceliophthora thermophila in detergentless microemulsions and assessment of its antioxidant and cytotoxicity activities

D. Kletsas, U. Rova, P. Christakopoulos, 2017 .

The antimitotic pyrimido[4,5-c]quinolin-1(2H)-one scaffold: probing substituents at position 3

D. Kletsas, H. Pratsinis, K. Metwally, 2015, Medicinal Chemistry Research.

Synthesis, in vitro Cytotoxicity, and a Preliminary Structure—Activity Relationship Investigation of Pyrimido[4,5‐c]quinolin‐1(2H)‐ones.

D. Kletsas, H. Pratsinis, A. Khalil, 2010 .

p53, p21(WAF1/CIP1), and MDM2 involvement in proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells.

A. Hughes, J. Hsieh, D. Kletsas, 2000, Arteriosclerosis, thrombosis, and vascular biology.

Evaluation of the anti-inflammatory and cytotoxic activities of naphthazarine derivatives from Onosma leptantha.

D. Kletsas, H. Pratsinis, N. Kovačević, 2006, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Low-power laser effects at the single-cell level: a confocal microscopy study

Eleni Alexandratou, Dido Yova, Spyros Loukas, 2000, European Conference on Biomedical Optics.

Evaluation of senescent cells in intervertebral discs by lipofuscin staining

D. Kletsas, V. Gorgoulis, K. Evangelou, 2021, Mechanisms of Ageing and Development.

Genistein suppresses the invasive potential of human breast cancer cells through transcriptional regulation of metalloproteinases and their tissue inhibitors.

A. Theocharis, D. Kletsas, A. Roussidis, 2005, International journal of oncology.

Heterogeneity of Cellular Senescence: Cell Type-Specific and Senescence Stimulus-Dependent Epigenetic Alterations

G. Castellani, E. Mavrogonatou, D. Kletsas, 2023, Cells.

Guided cell adhesion, orientation, morphology and differentiation on silicon substrates photolithographically micropatterned with a cell-repellent cross-linked poly(vinyl alcohol) film

E. Mavrogonatou, D. Kletsas, A. Douvas, 2018, Biomedical materials.

Why do intervertebral discs degenerate ? Presentation of the European research project EURODISC.

Jmrj Jacques Huyghe, J. Urban, M. Battié, 2006 .

Effect of PDGF and TGF‐β on the release of biogenic amines from invertebrate immunocytes and their possible role in the stress response

D. Kletsas, E. Ottaviani, Eva Caselgrandi, 1997, FEBS letters.

Extracellular matrix: The dynamic structural and functional network in health and disease

S. Ricard-Blum, D. Kletsas, Nikos Karamanos, 2022, IUBMB life.

Design and Synthesis of Novel Quinazolinone-Chalcone Hybrids as Potential Apoptotic Candidates Targeting Caspase-3 and PARP-1: In Vitro, Molecular docking, and SAR Studies

D. Kletsas, H. Pratsinis, A. A. Al-karmalawy, 2022, New Journal of Chemistry.

Oxygen plasma micro-nanostructured PMMA plates and microfluidics for increased adhesion and proliferation of cancer versus normal cells: The role of surface roughness and disorder

E. Gogolides, V. Constantoudis, D. Kletsas, 2020 .

EGFR and HER2 exert distinct roles on colon cancer cell functional properties and expression of matrix macromolecules.

A. Aletras, A. Theocharis, D. Kletsas, 2014, Biochimica et biophysica acta.

Greek centenarians: Assessment of functional health status and life-style characteristics

D. Kletsas, H. Pratsinis, I. Zachos, 2005, Experimental Gerontology.

Intracellular photoinduced oxidative stress by zinc phthalocyanine photosensitization: a study of the early events in real time using confocal microscopy

Dido M. Yova, Eleni Alexandratou, Spyros Loukas, 2003, European Conference on Biomedical Optics.

Synthesis and antiproliferative activity of substituted benzopyranoisoindoles: a new class of cytotoxic compounds.

D. Kletsas, H. Pratsinis, P. Marakos, 2006, Bioorganic & Medicinal Chemistry Letters.

A Novel Experimental Rat Model for the In Vivo Assessment of Myocardial Ischemia Based on Single Photon Emission Computed Tomography

I. Grypari, G. Loudos, D. Kletsas, 2023, In Vivo.

Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer

J. Bartek, W. Gu, J. Bártková, 2013, Nature Cell Biology.

In vitro studies on ultrasmall superparamagnetic iron oxide nanoparticles coated with gummic acid for T2 MRI contrast agent.

D. Kletsas, G. Drossopoulou, E. Tsilibary, 2007, Biomicrofluidics.

Biological Activities of Ceratonia siliqua Pod and Seed Extracts: A Comparative Analysis of Two Cretan Cultivars

D. Kletsas, H. Katerinopoulos, H. Pratsinis, 2023, International journal of molecular sciences.

Data on the putative role of p53 in breast cancer cell adhesion: Technical information for adhesion assay

D. Kletsas, G. Tzanakakis, D. Nikitovic, 2016, Data in brief.

A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer

C. Logothetis, G. Blandino, D. Kletsas, 2023, Journal of Experimental & Clinical Cancer Research.

The Proinflammatory Phenotype of Senescent Cells: The p53‐Mediated ICAM‐1 Expression

Dimitris Kletsas, Vassilis G Gorgoulis, D. Kletsas, 2004, Annals of the New York Academy of Sciences.

Hyperjovinols A and B: Two new phloroglucinol derivatives from Hypericum jovis with antioxidant activity in cell cultures.

D. Kletsas, A. Skaltsounis, H. Pratsinis, 2004, Journal of natural products.

Human lung fibroblasts prematurely senescent after exposure to ionizing radiation enhance the growth of malignant lung epithelial cells in vitro and in vivo.

D. Kletsas, A. Papadopoulou, 2011, International journal of oncology.

Ionizing radiation-mediated premature senescence and paracrine interactions with cancer cells enhance the expression of syndecan 1 in human breast stromal fibroblasts: the role of TGF-β

E. Mavrogonatou, D. Kletsas, V. Gorgoulis, 2016, Aging.

The CRH‐ACTH‐biogenic amine axis in invertebrate immunocytes activated by PDGF and TGF‐β

D. Kletsas, E. Ottaviani, Eva Caselgrandi, 1998, FEBS letters.

Tamoxifen Inhibits TGF‐β‐Mediated Activation of Myofibroblasts by Blocking Non‐Smad Signaling Through ERK1/2

C. Heldin, A. Moustakas, H. van Dam, 2015, Journal of cellular physiology.

Multiple functions of gingival and mucoperiosteal fibroblasts in oral wound healing and repair.

D. Kletsas, M. Chiquet, C. Katsaros, 2015, Periodontology 2000.

Chemical and biological evaluation of plants from the Greek flora towards their use as cosmetics

D. Kletsas, A. Fotopoulou, A. Papachristodoulou, 2022, GA – 70th Annual Meeting 2022.

The Unexpected Anabolic Phenotype and Extended Longevity of Skin Fibroblasts after Chronic Glucocorticoid Excess

D. Kletsas, H. Pratsinis, S. Tsagarakis, 2006, Dose-response : a publication of International Hormesis Society.