C. Koch

C. Koch, C. Shiue, A. Kachur, 2001, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

, Sylvain Chemtob , Nahid Waleh , Cameron J . Koch production and prevents ductus arteriosus reopening Tissue hypoxia inhibits prostaglandin and nitric oxide

C. Koch, S. Chemtob, N. Waleh, 2000 .

Tissue hypoxia inhibits prostaglandin and nitric oxide production and prevents ductus arteriosus reopening.

C. Koch, S. Chemtob, N. Waleh, 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

Permanent Anatomic Closure of the Ductus Arteriosus in Newborn Baboons: The Roles of Postnatal Constriction, Hypoxia, and Gestation

C. Koch, S. Evans, S. Seidner, 1999, Pediatric Research.

Imaging hypoxia and blood flow in normal tissues.

C. Koch, S. Evans, I. Shapiro, 1997, Advances in experimental medicine and biology.

Imaging hypoxia in diseased tissues.

H. Hermeking, D. Ferriero, F. Sharp, 1997, Advances in Experimental Medicine and Biology.

Detection of individual hypoxic cells in multicellular spheroids by flow cytometry using the 2-nitroimidazole, EF5, and monoclonal antibodies.

C. Koch, E. Lord, M. Woods, 1996, International journal of radiation oncology, biology, physics.

Binding of misonidazole to EMt6 and V79 spheroids.

C. Koch, J. D. Chapman, A. Franko, 1982, International journal of radiation oncology, biology, physics.

2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9L s.c. tumors.

C. Koch, W. T. Jenkins, S. Evans, 1996, Cancer research.

Energy metabolism and T-cell-mediated cytolysis. I. Synergism between inhibitors of respiration and glycolysis

H. Macdonald, C. Koch, 1977, The Journal of experimental medicine.

Hypoxic Heterogeneity in Human Tumors

C. Koch, S. Evans, S. Hahn, 2001 .

Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension

J. Flynn, C. Koch, Guofeng Zhu, 2006, Cellular microbiology.

p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment

Y. Pan, C. Koch, M. Simon, 2004, Oncogene.

The effect of extreme hypoxia on the repair of DNA single-strand breaks in mammalian cells.

C. Koch, R. Painter, 1975, Radiation research.

Mercuric compounds inhibit human monocyte function by inducing apoptosis: evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve.

C. Koch, I. Shapiro, B. Shenker, 1997, Toxicology.

Radiosensitization of hypoxic tumor cells by dodecafluoropentane: a gas-phase perfluorochemical emulsion.

C. Koch, W. T. Jenkins, S. Evans, 2002, Cancer research.

Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts.

L. Harwell, C. Koch, E. Lord, 1993, Cancer research.

Interleukin 2 expression by tumor cells alters both the immune response and the tumor microenvironment.

B. Fenton, C. Koch, J. Frelinger, 1998, Cancer research.

pO(2)-dependent NO production determines OPPC activity in macrophages.

C. Koch, C. Otto, M. Robinson, 2010, Free radical biology & medicine.

Binding of misonidazole to hypoxic cells in monolayer and spheroid culture: evidence that a side-chain label is bound as efficiently as a ring label.

C. Koch, J. Raleigh, A. Franko, 1985, British Journal of Cancer.

Variation in radiation response of mammalian cells as a function of oxygen tension.

C. Koch, J. Kruuv, H. Frey, 1973, Radiation research.

The effect of extreme hypoxia and glucose on the repair of potentially lethal and sublethal radiation damage by mammalian cells.

J. Harris, C. Koch, J. Meneses, 1977, Radiation research.

Biodistribution and dosimetry of 18F-EF5 in cancer patients with preliminary comparison of 18F-EF5 uptake versus EF5 binding in human glioblastoma

Janet S. Reddin, J. Karp, J. Scheuermann, 2010, European Journal of Nuclear Medicine and Molecular Imaging.

Metabolism and radiosensitization of 4,5-dimethylmisonidazole, a ring-substituted analog of misonidazole.

C. Koch, B. R. Smith, J. Born, 1992, Biochemical pharmacology.

Detection of Reactive Oxygen Species via Endogenous Oxidative Pentose Phosphate Cycle Activity in Response to Oxygen Concentration

A. Maity, C. Koch, A. Kachur, 2007, Journal of Biological Chemistry.

Tumor response to radiotherapy is dependent on genotype-associated mechanisms in vitro and in vivo

J. Little, D. Gridley, Jerry R. Williams, 2010, Radiation oncology.

The radiation response of cells from 9L gliosarcoma tumours is correlated with [F18]-EF5 uptake

J. Karp, C. Koch, W. T. Jenkins, 2009, International journal of radiation biology.

Enhancement of X-ray induced potentially lethal damage by low temperature storage of mammalian cells.

C. Koch, H. Burki, 1977, The British journal of radiology.

Combined radiation-protective and radiation-sensitizing agents. IV: Measurement of intracellular protector concentrations.

C. Koch, C. Stobbe, P. Hettiaratchi, 1989, International journal of radiation oncology, biology, physics.

Oxygen effects in radiobiology.

C. Koch, 1982, Advances in experimental medicine and biology.

4 – Chemical Modifiers of Radiation Response

J. Brown, C. Koch, M. Parliament, 2010 .

EF5 binding and clinical outcome in human soft tissue sarcomas.

D. Fraker, W. Hwang, S. Hahn, 2006, International journal of radiation oncology, biology, physics.

Intratumoral Hypoxia Reduces IFN-

S. Gerber, C. Koch, E. Lord, 2019 .

Intratumoral Hypoxia Reduces IFN-γ–Mediated Immunity and MHC Class I Induction in a Preclinical Tumor Model

S. Gerber, C. Koch, E. Lord, 2019, ImmunoHorizons.

Non‐invasive evaluation of tumour hypoxia in the Shionogi tumour model for prostate cancer with 18F‐EF5 and positron emission tomography

M. Gleave, C. Koch, T. Ruth, 2007, BJU international.

Non-invasive evaluation of tumour hypoxia in the Shionogi tumour model for prostate cancer with 18 FEF 5 and positron emission tomography

M. Gleave, C. Koch, T. Ruth, 2007 .

In vivo colocalization of 2-nitroimidazole EF5 fluorescence intensity and electron paramagnetic resonance oximetry in mouse tumors.

V. Grégoire, J. Gueulette, P. Mahy, 2003, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Measurement of low levels of oxygen and their effect on respiration in cell suspensions maintained in an open system.

C. Koch, A. Rauth, R. Marshall, 1986, Radiation research.

Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts

C. Koch, D. Siemann, E. Lord, 1996, International journal of cancer.

Binding of 3H-misonidazole to solid human tumors as a measure of tumor hypoxia.

C. Koch, J. Raleigh, A. Franko, 1986, International journal of radiation oncology, biology, physics.

Tumor vascular changes mediated by inhibition of oncogenic signaling.

R. Muschel, J. Im, E. Bernhard, 2009, Cancer research.

Imaging and Analytical Methods as Applied to the Evaluation of Vasculature and Hypoxia in Human Brain Tumors

T. Dilling, S. Hahn, K. Judy, 2008, Radiation research.

Autocrine erythropoietin signaling inhibits hypoxia-induced apoptosis in human breast carcinoma cells.

C. Koch, Xiaowei Xu, G. Acs, 2004, Cancer letters.

The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras.

R. Muschel, E. Bernhard, C. Koch, 2001, Cancer research.

Role of scavenger-derived radicals in the induction of double-strand and single-strand breaks in irradiated DNA.

C. Koch, I. Ayene, R. Krisch, 1995, Radiation research.

Improved Methods to Generate Spheroid Cultures from Tumor Cells, Tumor Cells & Fibroblasts or Tumor-Fragments: Microenvironment, Microvesicles and MiRNA

C. Koch, W. T. Jenkins, S. Evans, 2015, PloS one.

Studies of type IV collagenase regulation by hypoxia.

C. Koch, B. Himelstein, 1998, Cancer letters.

Quantification of tumour vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurements

B. Fenton, C. Koch, E. Lord, 1999, British Journal of Cancer.

The Farnesyltransferase Inhibitor L 744 , 832 Reduces Hypoxia in Tumors Expressing

R. Muschel, E. Bernhard, C. Koch, 2001 .

Effect of local irradiation on tumor oxygenation, perfused vessel density, and development of hypoxia.

B. Fenton, C. Koch, E. Lord, 1998, Advances in experimental medicine and biology.

Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide].

C. Koch, W. T. Jenkins, K. M. Laughlin, 1995, British Journal of Cancer.

Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis (vol 394, pg 485, 1998)

P. Carmeliet, R. Jain, M. Neeman, 1998 .

Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and γ radiation

C. Koch, L. Ford, I. Ayene, 2005, Molecular Cancer Therapeutics.

VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus.

C. Koch, S. Seidner, N. Ferrara, 2002, American journal of physiology. Regulatory, integrative and comparative physiology.

Radiation Response of Cells during Altered Protein Thiol Redox

C. Koch, J. Mieyal, T. Stamato, 2003, Radiation research.

A Two-Component Assay for Hypoxia Incorporating Long-Term Nitroreduction and Short-Term DNA-Damage Allows Differentiation of the Three Hypoxia Sub-types

C. Koch, 2018, Radiation Research.

Invited editorial for the paper by Silvoniemi et al. “Repeatability of tumor hypoxia imaging using [18F]EF5 PET/CT in head and neck cancer.” in this issue of EJNMMI

C. Koch, 2018, European Journal of Nuclear Medicine and Molecular Imaging.

Retinoic acid modulation of glutathione and cysteine metabolism in chondrocytes.

C. Koch, I. Shapiro, C. Teixeira, 1996, The Biochemical journal.

Tissue oxygen sensing and the carotid body.

S. Lahiri, S. Vinogradov, C. Koch, 1998, Advances in experimental medicine and biology.

Tamoxifen induces hypoxia in MCF-7 xenografts.

C. Koch, W. T. Jenkins, K. M. Laughlin, 1997, Cancer Research.

Plateau phase in growth induced by hypoxia.

C. Koch, J. Kruuv, H. Frey, 1973, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Intracellular PO2 of the carotid body.

S. Lahiri, C. Koch, K. M. Laughlin, 2000, Advances in experimental medicine and biology.

Radiation response and other characteristics of the 9l rat glioma grown as an epigastric tissue isolate

C. Koch, S. Evans, 1994 .

Hypoxia induces renal tubular epithelial cell apoptosis in chronic renal disease.

C. Koch, J. Schelling, R. Cleveland, 1999, Laboratory investigation; a journal of technical methods and pathology.

Re: Differential impact of FLASH versus conventional dose rate irradiation: Spitz et al.

C. Koch, 2019, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

The importance of sodium pyruvate in assessing damage produced by hydrogen peroxide.

C. Koch, C. Stevens, J. Biaglow, 1997, Free radical biology & medicine.

A model of wound healing in chronically radiation-damaged rat skin.

S. Thom, C. Koch, S. Evans, 1998, Cancer letters.

Radiation-induced DNA damage in tumors and normal tissues. III. Oxygen dependence of the formation of strand breaks and DNA-protein crosslinks.

C. Koch, K. Wheeler, H. Zhang, 1995, Radiation research.

Oxygen dependence of product formation in irradiated adenosine 5'-monophosphate.

C. Koch, J. Raleigh, A. F. Fuciarelli, 1988, Radiation research.

PARP-1 Expression Quantified by [18F]FluorThanatrace: A Biomarker of Response to PARP Inhibition Adjuvant to Radiation Therapy.

R. Mach, C. Koch, D. Pryma, 2017, Cancer biotherapy & radiopharmaceuticals.

Combined Prostaglandin and Nitric Oxide Inhibition Produces Anatomic Remodeling and Closure of the Ductus Arteriosus in the Premature Newborn Baboon

C. Koch, S. Seidner, R. Clyman, 2001, Pediatric Research.

Factors that increase the contractile tone of the ductus arteriosus also regulate its anatomic remodeling.

C. Koch, S. Seidner, S. Chemtob, 2001, American journal of physiology. Regulatory, integrative and comparative physiology.

The oxygen-enhancement ratio for reproductive death induced by 3H or 125I damage in mammalian cells.

C. Koch, H. Burki, 1975, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Mechanism of production of hydroxyl radicals in the copper-catalyzed oxidation of dithiothreitol.

C. Koch, K. Held, A. Kachur, 1997, Radiation Research.

The alkaline elution technique for measuring DNA single strand breaks: increased reliability and sensitivity.

C. Koch, A. Giandomenico, 1994, Analytical biochemistry.

The effect on the Km for radiosensitization at 0 degree C of thiol depletion by diethylmaleate pretreatment: quantitative differences found using the radiation sensitizing agent misonidazole or oxygen.

C. Koch, E. Bump, C. Stobbe, 1984, Radiation research.

A thin-film culturing technique allowing rapid gas-liquid equilibration (6 sec) with no toxicity to mammalian cells.

C. Koch, 1984, Radiation research.

Comment on the hypothesis that hyperthermia facilitates reoxygenation.

C. Koch, S. Evans, E. Lord, 1995, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Human Esophageal Cancer Is Distinguished from Adjacent Esophageal Tissue by Tissue Cysteine Concentrations

C. Koch, S. Evans, E. Wileyto, 2002, Digestive Diseases and Sciences.

In regard to Brown et al. (Int J Radiat Oncol Biol Phys 2010;78:323-327).

C. Koch, S. Evans, 2011, International journal of radiation oncology, biology, physics.

Quantitative spatial analysis of hypoxia and vascular perfusion in tumor sections.

C. Koch, S. Evans, T. Busch, 2003, Advances in experimental medicine and biology.

correction: Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

P. Carmeliet, R. Jain, M. Neeman, 1998, Nature.

Role of Vicinal Protein Thiols in Radiation and Cytotoxic Responses

C. Koch, J. Mieyal, J. Biaglow, 2006, Radiation research.

G6PD deficient cells and the bioreduction of disulfides: effects of DHEA, GSH depletion and phenylarsine oxide.

C. Koch, T. Stamato, J. Biaglow, 2000, Biochemical and biophysical research communications.

Oxidation of cellular thiols by hydroxyethyldisulphide inhibits DNA double-strand-break rejoining in G6PD deficient mammalian cells.

C. Koch, T. Stamato, J. Biaglow, 2000, International journal of radiation biology.

Pharmacokinetics of EF5 [2-(2-nitro-1-H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide] in human patients: implications for hypoxia measurements in vivo by 2-nitroimidazoles

C. Koch, W. Mckenna, J. Covey, 2001, Cancer Chemotherapy and Pharmacology.

Vasa Vasorum Hypoperfusion Is Responsible for Medial Hypoxia and Anatomic Remodeling in the Newborn Lamb Ductus Arteriosus

C. Koch, C. Roman, R. Clyman, 2002, Pediatric Research.

Evaluation of the concept of "hypoxic fraction" as a descriptor of tumor oxygenation status.

C. Koch, W. T. Jenkins, S. Evans, 1997, Advances in experimental medicine and biology.

Distribution of misonidazole adducts in 9L gliosarcoma tumors and spheroids: implications for oxygen distribution.

C. Koch, A. Franko, D. Boisvert, 1992, Cancer research.

The Effect of Oxygen on the Repair of Radiation Damage by Cells and Tissues1

C. Koch, 1979 .

The radiation response of hypoxic cells in EMT6 spheroids in suspension culture does model data from EMT6 tumors.

C. Koch, A. Franko, 1983, Radiation research.

Radiation dosimetry and biodistribution of the hypoxia tracer (18)F-EF5 in oncologic patients.

H. Minn, S. Hahn, C. Koch, 2012, Cancer biotherapy & radiopharmaceuticals.

Tumor hypoxia as a modifier of DNA strand break and cross-link repair.

R. Bristow, C. Koch, N. Chan, 2009, Current molecular medicine.

Alteration of tumour response to radiation by interleukin-2 gene transfer

B. Fenton, C. Koch, P. Keng, 2000, British Journal of Cancer.

Monoclonal antibodies differentially reactive with native and reductively modified Bowman-Birk protease inhibitor.

C. Koch, P. Billings, E. Lord, 1995, Journal of immunological methods.

Mechanisms of blood flow and hypoxia production in rat 9L-epigastric tumors.

C. Koch, W. T. Jenkins, S. Evans, 2012, Tumor microenvironment and therapy.

Novel Double-Hit Model of Radiation and Hyperoxia-Induced Oxidative Cell Damage Relevant to Space Travel

C. Koumenis, C. Koch, T. Goodwin, 2016, International journal of molecular sciences.

Biodistribution of the nitroimidazole EF5 (2-[2-nitro-1H-imidazol-1-yl]-N-(2,2,3,3,3-pentafluoropropyl) acetamide) in mice bearing subcutaneous EMT6 tumors.

C. Koch, W. T. Jenkins, C. Chan, 1996, The Journal of pharmacology and experimental therapeutics.

Comparisons of cellular radiation response using absolute rather than relative parameters.

C. Koch, K. Skov, 1992, Radiation research.

Genotype-dependent radiosensitivity: Clonogenic survival, apoptosis and cell-cycle redistribution

J. Little, D. Gridley, Jerry R. Williams, 2008, International journal of radiation biology.

Effects of hyperbaric oxygen exposure on experimental head and neck tumor growth, oxygenation, and vasculature

S. Thom, E. Bernhard, A. Maity, 2005, Head & neck.

AN EFFECTIVE SYNTHETIC ROUTE TO EF5

C. Koch, S. Rettig, B. James, 1998 .

Quantitation of hypoxia in multicellular spheroids by video image analysis.

Gerald G. Miller, C. Koch, G. Miller, 1989, International journal of radiation oncology, biology, physics.

Binding of misonidazole to V79 spheroids and fragments of Dunning rat prostatic and human colon carcinomas in vitro: diffusion of oxygen and reactive metabolites.

C. Koch, A. Franko, Cameron J. Koch, 1984, International journal of radiation oncology, biology, physics.

Mechanism of copper-catalyzed oxidation of glutathione.

C. Koch, A. Kachur, J. Biaglow, 1998, Free radical research.

Catalysis of fluorine addition to double bond: an improvement of method for synthesis of (18)F PET agents.

C. Koch, W. Xu, A. Kachur, 2010, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

The boys in the island

C. Koch, 1958 .

Synthesis of new hypoxia markers EF1 and [18F]-EF1.

C Y Shiue, S M Evans, C. Koch, 1999, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Biodegradable Polymersomes for the Delivery of Gemcitabine to Panc-1 Cells

D. Hammer, C. Koch, W. T. Jenkins, 2013, Journal of pharmaceutics.

Simulation of the cellular oxygen effect with an SV40 DNA model system using DNA strand breaks as an end point.

C. Koch, I. Ayene, R. Krisch, 1996, Radiation research.

Modification of radiation-induced strand breaks by glutathione: comparison of single- and double-strand breaks in SV40 DNA.

C. Koch, I. Ayene, R. Krisch, 1995, Radiation research.

Radiolytic reduction of protein and nonprotein disulfides in the presence of formate: a chain reaction.

C. Koch, J. Raleigh, 1991, Archives of biochemistry and biophysics.

Hypoxia Is Important in the Biology and Aggression of Human Glial Brain Tumors

Peter T. Nelson, M. Grady, W. Hwang, 2004, Clinical Cancer Research.

Comparative Measurements of Hypoxia in Human Brain Tumors Using Needle Electrodes and EF5 Binding

Peter T. Nelson, B. Geoerger, S. Hahn, 2004, Cancer Research.

Effect of sub-optimal temperatures on survival of mammalian cells.

C. Koch, J. Kruuv, H. Frey, 1971, Experimental cell research.

Toxicity, radiation sensitivity modification, and metabolic effects of dehydroascorbate and ascorbate in mammalian cells ,

C. Koch, J. Biaglow, 1978, Journal of cellular physiology.

Cell survival in V79 multicell spheroids treated with dehydroascorbate, 5-thio-D-glucose and 2-deoxy-D-glucose.

C. Koch, R. Sridhar, W. R. Inch, 1978, The British journal of cancer. Supplement.

THE OXIDATION OF ASCORBATE BY ELECTRON AFFINIC DRUGS AND CARCINOGENS

C. Koch, M. Varnes, J. Biaglow, 1978, Photochemistry and photobiology.

Factors influencing the oxygen consumption and radiation response of cultured mammalian cells.

C. Koch, M. Varnes, J. Biaglow, 1983, Advances in experimental medicine and biology.

Ascorbate anion potentiates cytotoxicity of nitro-aromatic compounds under hypoxic and anoxic conditions.

C. Koch, J. Biaglow, R. L. Howell, 1979, British Journal of Cancer.

The catalytic effect of the carcinogen "4-nitroquinoline-N-oxide" on the oxidation of vitamin C.

C. Koch, J. Biaglow, B. Jacobson, 1976, Biochemical and biophysical research communications.

Respiration of mammalian cells at low concentrations of oxygen: I. Effect of hypoxic-cell radiosensitizing drugs.

C. Koch, J. Biaglow, 1978, The British journal of cancer. Supplement.

Letter to the Editor Re: Ogawa, Y. Cancers 2016, 8, 28

C. Koch, 2016, Cancers.

Pharmacokinetics and cytotoxicity of RSU-1069 in subcutaneous 9L tumours under oxic and hypoxic conditions.

K. Wong, C. Koch, K. Wheeler, 1991, British Journal of Cancer.

Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin.

C. Koch, 1993, Cancer research.

The measurement of bioreductive capacity of tumor cells using methylene blue.

E. Bernhard, C. Koch, W. Mckenna, 1998, International journal of radiation oncology, biology, physics.

Radioprotection of DNA in isolated nuclei by naturally occurring thiols at intermediate oxygen tension.

C. Koch, E. Bump, R. Al-Sarraf, 1992, Radiation research.

Radiosensitization/radioprotection: methods of analysis.

C. Koch, 1985, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Combined radiation-protective and radiation-sensitizing agents: II. Radiosensitivity of hypoxic or aerobic Chinese hamster fibroblasts in the presence of cysteamine and misonidazole: implications for the "oxygen effect" (with appendix on calculation of dose-modifying factors).

C. Koch, R. L. Howell, 1981, Radiation research.

Radiosensitization of hypoxic mammalian cells by diamide. I. Effects of experimental conditions on survival.

J. Harris, C. Koch, J. A. Power, 1975, Radiation research.

Measurements of very low oxygen tensions in unstirred liquids

C. Koch, J. Kruuv, 1972 .

In situ oxygen utilization in the rat intervertebral disc

C. Koch, S. Evans, I. Shapiro, 2007, Journal of anatomy.

Hypoxia and VEGF mRNA expression in human tumors.

A. Maity, C. Koch, S. Evans, 2001, Neoplasia.

In vivo profiling of hypoxic gene expression in gliomas using the hypoxia marker EF5 and laser-capture microdissection.

A. Hatzigeorgiou, P. Alexiou, J. Tobias, 2011, Cancer research.

Mutation in G6PD gene leads to loss of cellular control of protein glutathionylation: Mechanism and implication

C. Koch, A. Kachur, T. Stamato, 2008, Journal of cellular biochemistry.

Measurement of absolute oxygen levels in cells and tissues using oxygen sensors and 2-nitroimidazole EF5.

C. Koch, Cameron J Koch, 2002, Methods in enzymology.

Induction of apoptosis at different oxygen tensions: evidence that oxygen radicals do not mediate apoptotic signaling.

R. Muschel, E. Bernhard, C. Koch, 1995, Cancer research.

Prognostic significance of tumor oxygenation in humans.

C. Koch, S. Evans, Cameron J Koch, 2003, Cancer letters.

Single‐cell measurement of the uptake, intratumoral distribution and cell cycle effects of cisplatin using mass cytometry

O. Ornatsky, S. Tanner, D. Hedley, 2015, International journal of cancer.

Candidate genes for the hypoxic tumor phenotype.

A. Koong, A. Giaccia, Q. Le, 2000, Cancer research.

Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker.

C. Koch, M. Knapp, K. Laderoute, 1995, Cancer research.

The effect of extreme hypoxia on recovery after radiation by synchronized mammalian cells.

C. Koch, J. Kruuv, 1971, Radiation research.

Myocyte apoptosis during acute myocardial infarction in the mouse localizes to hypoxic regions but occurs independently of p53.

R. Kitsis, C. Koch, S. Evans, 1997, The Journal of clinical investigation.

Hypoxia in the Androgen-Dependent Shionogi Model for Prostate Cancer at Three Stages1

M. Gleave, C. Koch, M. Bowden, 2004, Radiation research.

Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy.

S. Hahn, E. Bernhard, A. Maity, 2006, Cancer research.

The Relationship among Hypoxia, Proliferation, and Outcome in Patients with De Novo Glioblastoma: A Pilot Study.

M. Grady, W. Hwang, S. Hahn, 2010, Translational oncology.

Response of V79 cells to low doses of X-rays and negative pi-mesons: clonogenic survival and DNA strand breaks.

C. Koch, B. Marples, H. Adomat, 1996, International journal of radiation biology.

DNA damaging agents improve stable gene transfer efficiency in mammalian cells.

C. Koch, C. Stevens, G. Cerniglia, 1998, Radiation oncology investigations.

Low pO2 and β-Estradiol Induce VEGF in MCF-7 and MCF-7-5C Cells: Relationship to in vivo Hypoxia

A. Maity, C. Koch, S. Evans, 2001, Breast Cancer Research and Treatment.

Effects of ultra-high dose rate FLASH irradiation on the tumor microenvironment in Lewis lung carcinoma: role of myosin light chain.

I. Weissman, B. Loo, P. Maxim, 2020, International journal of radiation oncology, biology, physics.

p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia.

T. Burns, W. El-Deiry, P. Cohen, 2005, The Journal of clinical endocrinology and metabolism.

Mechanism of copper-catalyzed autoxidation of cysteine.

C. Koch, A. Kachur, J. Biaglow, 1999, Free radical research.

Effect of etanidazole on absolute sensitivity and increased radioresistance in hypoxic cells at low doses

C. Koch, B. Marples, K. Skov, 1994 .

Hypoxia and necrosis in rat 9L glioma and Morris 7777 hepatoma tumors: comparative measurements using EF5 binding and the Eppendorf needle electrode.

S M Evans, C. Koch, W. T. Jenkins, 2000, International journal of radiation oncology, biology, physics.

Misonidazole: inter-related factors affecting cytotoxicity.

C. Koch, R. L. Howell, 1982, International Journal of Radiation Oncology, Biology, Physics.

The Reduction Activation of Nitroimidazoles; Modification by Oxygen and other Redox-Active Molecules in Cellular Systems

C. Koch, 1990 .

DNA as an important target in radiation-induced apoptosis of MYC and MYC plus RAS transfected rat embryo fibroblasts.

R. Muschel, E. Bernhard, C. Koch, 2000, International journal of radiation biology.

Bioreductive metabolism of AF-2[2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide] combined with 2-nitroimidazoles. Implications for use as hypoxic cell markers.

C. Koch, A. Giandomenico, C. Iyengar, 1993, Biochemical pharmacology.

Metabolism induced binding of 14C-misonidazole to hypoxic cells: kinetic dependence on oxygen concentration and misonidazole concentration.

C. Koch, C. Stobbe, K. A. Baer, 1984, International journal of radiation oncology, biology, physics.

Pharmacokinetic and Pharmacodynamic Modifiers of EF5 Uptake and Binding

C. Koch, S. Evans, 2015, The Journal of Nuclear Medicine.

Oxygen levels in normal and previously irradiated human skin as assessed by EF5 binding.

Paul Zhang, A. Chalian, C. Koch, 2006, The Journal of investigative dermatology.

Oxygen dependence of cellular uptake of EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl)a cet amide] : analysis of drug adducts by fluorescent antibodies vs bound radioactivity.

C. Koch, S. Evans, E. Lord, 1995, British Journal of Cancer.

Oxygen dependence of binding of misonidazole to rodent and human tumors in vitro.

C. Koch, D. Hughes, A. Franko, 1987, Cancer research.

Fluorescence immunohistochemical detection of hypoxic cells in spheroids and tumours.

C. J. Koch, C. Koch, G. Miller, 1987, British Journal of Cancer.

A novel technique for measuring human tissue pO2 at the cellular level.

C. J. Koch, C. Koch, J. D. Chapman, 1986, British Journal of Cancer.

Combined radiation-protective and radiation-sensitizing agents. III: Radiosensitization by misonidazole as a function of concentrations of endogenous glutathione or exogenous thiols.

C. Koch, C. Stobbe, K. A. Baer, 1986, International journal of radiation oncology, biology, physics.

Initial evidence that blood-borne microvesicles are biomarkers for recurrence and survival in newly diagnosed glioblastoma patients

S. Brem, R. Wolf, M. Putt, 2016, Journal of Neuro-Oncology.

Microvesicles as a Biomarker for Tumor Progression versus Treatment Effect in Radiation/Temozolomide-Treated Glioblastoma Patients

R. Wolf, C. Koch, W. T. Jenkins, 2014, Translational oncology.

Detection of hypoxic cells with the 2-nitroimidazole, EF5, correlates with early redox changes in rat brain after perinatal hypoxia–ischemia

D. Ferriero, F. Sharp, C. Koch, 1999, Neuroscience.

Non-invasive PET and SPECT imaging of tissue hypoxia using isotopically labeled 2-nitroimidazoles.

C. Koch, S. Evans, Cameron J Koch, 2003, Advances in experimental medicine and biology.

Decreased brain infarct following focal ischemia in mice lacking the transcription factor E2F1.

C. Koch, C J Koch, J P MacManus, 1999, Neuroreport.

Overview of radiosensitivity of human tumor cells to low-dose-rate irradiation.

J. Little, D. Gridley, Jerry R. Williams, 2008, International journal of radiation oncology, biology, physics.

Candidate Genes for the Hypoxic Tumor Phenotype 1

A. Koong, A. Giaccia, Q. Le, 2000 .

In regard to Vordermark et al. (Int J Radiat Oncol Biol Phys 2004;58:1242-1250).

C. Koch, Cameron J Koch, 2004, International journal of radiation oncology, biology, physics.

Mutation in the Glucose-6-phosphate Dehydrogenase Gene Leads to Inactivation of Ku DNA End Binding during Oxidative Stress*

C. Koch, T. Stamato, J. Biaglow, 2002, The Journal of Biological Chemistry.

Effect of oxygen on radiation-induced DNA damage in isolated nuclei.

C. Koch, A. Giandomenico, A. Horan, 1999, Radiation research.

Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.

James B. Mitchell, A. Harris, G. Semenza, 2004, Cancer research.

Detection of hypoxia in human squamous cell carcinoma by EF5 binding.

S M Evans, E M Lord, R. Weber, 2000, Cancer research.

Epidermal Growth Factor Receptor Inhibition Modulates the Microenvironment by Vascular Normalization to Improve Chemotherapy and Radiotherapy Efficacy

Arjun G. Yodh, Chandra M. Sehgal, Regine Choe, 2009, PloS one.

Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome.

G. Weinstein, A. Chalian, H. Quon, 2007, International journal of radiation oncology, biology, physics.

Hypoxia and Photofrin Uptake in the Intraperitoneal Carcinomatosis and Sarcomatosis of Photodynamic Therapy Patients

Michael J. Emanuele, D. Fraker, M. Putt, 2004, Clinical Cancer Research.

Hypoxia in human intraperitoneal and extremity sarcomas.

S. Hahn, D. Fraker, C. Koch, 2001, International journal of radiation oncology, biology, physics.

Microenvironment and Immunology In Vivo Profiling of Hypoxic Gene Expression in Gliomas Using the Hypoxia Marker EF 5 and Laser-capture Microdissection

A. Hatzigeorgiou, P. Alexiou, J. Tobias, 2011 .

Hyperthermia-induced inhibition of respiration and mitochondrial protein denaturation in CHL cells.

C. Koch, J. Lepock, J. Kruuv, 1987, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Adaptation of chondrocytes to low oxygen tension: Relationship between hypoxia and cellular metabolism

C. Koch, I. Shapiro, Cristina Teixeira, 1996, Journal of cellular physiology.

Buoyant density of EMT6 fibrosarcoma cells: I. Effect of hypoxic growth conditions in vitro.

C. Koch, C. Ng, W. R. Inch, 1980, International journal of radiation oncology, biology, physics.

Human tumor cells segregate into radiosensitivity groups that associate with ATM and TP53 status

J. Little, Jerry R. Williams, Yonggang Zhang, 2007, Acta oncologica.

Early detection of radiation therapy response in non‐Hodgkin's lymphoma xenografts by in vivo 1H magnetic resonance spectroscopy and imaging

C. Koch, W. T. Jenkins, S. Kim, 2010, NMR in biomedicine.

Implications for Radiotherapy VEGF Expression and Increases Tumor Oxygenation : and α Nelfinavir Down-regulates Hypoxia-Inducible Factor 1

S. Hahn, E. Bernhard, A. Maity, 2006 .

Noninvasive imaging of tumor hypoxia in rats using the 2-nitroimidazole 18F-EF5

J. Karp, A. Alavi, J. Karp, 2003, European Journal of Nuclear Medicine and Molecular Imaging.

Extravascular diffusion of tirapazamine: effect of metabolic consumption assessed using the multicellular layer model.

W. Wilson, C. Koch, K. Hicks, 1998, International journal of radiation oncology, biology, physics.

The Km for Radiosensitization of Human Tumor Cells by Oxygen is Much Greater than 3 mmHg and is Further Increased by Elevated Levels of Cysteine

C. Koch, A. Horan, 2001, Radiation research.

Bioreductive metabolism of SR-4233 (WIN 59075) by whole cell suspensions under aerobic and hypoxic conditions: role of the pentose cycle and implications for the mechanism of cytotoxicity observed in air.

C. Coleman, C. Koch, J. Mitchell, 1994, International journal of radiation oncology, biology, physics.

The disaggregation, separation and identification of cells from irradiated and unirradiated EMT6 mouse tumors.

C. Koch, R. L. Howell, 1980, International journal of radiation oncology, biology, physics.

Hypoxia-mediated apoptosis from angiogenesis inhibition underlies tumor control by recombinant interleukin 12.

G. Trinchieri, C. Koch, W. T. Jenkins, 1999, Cancer research.

Depletion of tumor oxygenation during photodynamic therapy: detection by the hypoxia marker EF3 [2-(2-nitroimidazol-1[H]-yl)-N-(3,3,3-trifluoropropyl)acetamide ].

S. Hahn, C. Koch, S. Evans, 2000, Cancer research.

Preservation of functional and regulatory domains of expressed bcl-2 genes in non-Hodgkin's lymphoma.

H. Drexler, M. Werner, C. Koch, 1996, Leukemia.

Androgen withdrawal fails to induce detectable tissue hypoxia in the rat prostate

M. Hedayati, T. DeWeese, Yonggang Zhang, 2014, The Prostate.

The effect of hypoxia on the generation time of mammalian cells.

C. Koch, J. Kruuv, H. Frey, 1973, Radiation research.

Sequentially-induced responses define tumour cell radiosensitivity

J. Little, D. Gridley, Jerry R. Williams, 2011, International journal of radiation biology.

Synergistic chemical radiosensitization of hypoxic mammalian cells.

J. Harris, C. Koch, J. A. Power, 1976, International journal of radiation oncology, biology, physics.

Chondrocytes in the endochondral growth cartilage are not hypoxic.

C. Koch, S. Evans, I. Shapiro, 1997, The American journal of physiology.

Re: Devic et al. (Int J Radiat Oncol Biol Phys 2010;78:1555-1562).

C. Koch, S. Evans, 2011, International journal of radiation oncology, biology, physics.

Calibration of oxygen-dependent quenching of the phosphorescence of Pd-meso-tetra (4-carboxyphenyl) porphine: a phosphor with general application for measuring oxygen concentration in biological systems.

David F Wilson, C. Koch, L. Lo, 1996, Analytical biochemistry.

Oxygen supply to spheroids in spinner and liquid-overlay culture.

H. I. Freedman, C. Koch, A. Franko, 1984, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Interlaboratory variation in oxygen tension measurement by Eppendorf “Histograph” and comparison with hypoxic marker

S M Evans, E M Lord, H D Suit, 1997, Journal of surgical oncology.

Radiation-sensitive tyrosine phosphorylation of cellular proteins: sensitive to changes in GSH content induced by pretreatment with N-acetyl-L-cysteine or L-buthionine-S,R-sulfoximine.

C. Koch, J. Biaglow, Y. Manevich, 1998, International journal of radiation oncology, biology, physics.

Radiosensitization of hypoxic tumor cells by dodecafluoropentane: a gas-phase perfluorochemical emulsion.

C. Koch, W. T. Jenkins, S. Evans, 2002, Cancer research.

The release of oxygen from polystyrene Petri dishes.

C. Koch, J. Kruuv, 1972, The British journal of radiology.

Cytotoxicity of two nitroimidazole radiosensitizers in an in vitro tumor model.

C. Koch, R. Sutherland, R. Sridhar, 1976, International journal of radiation oncology, biology, physics.

Comment on the Paper by Van Der Schans et al.

C. Koch, J. Chapman, 1986 .

Cyanide insensitive respiration in mammalian cells: an artifact of mycoplasmal contamination.

C. Koch, J. Biaglow, 1983, Advances in experimental medicine and biology.

Recognition of platinum-induced DNA damage by nuclear proteins: screening for mechanisms.

N. Farrell, C. Koch, B. Marples, 1994, Anti-cancer drug design.

Molecular suicide studies of 125I and 3H disintegration in the DNA of Chinese hamster cells.

S. Wolff, C. Koch, H. Burki, 1978, Current topics in radiation research quarterly.

PARP-1 Expression Quantified by [18F]FluorThanatrace: A Biomarker of Response to PARP Inhibition Adjuvant to Radiation Therapy.

R. Mach, C. Koch, D. Pryma, 2017, Cancer biotherapy & radiopharmaceuticals.

In regard to Brown et al. (Int J Radiat Oncol Biol Phys 2010;78:323-327).

C. Koch, S. Evans, 2011, International journal of radiation oncology, biology, physics.