Haiying Zhang

发表

Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors.

Philip J. Merta, Gaoquan Li, Z. Tao, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 1-(2,4,5-trisubstituted phenyl)-3-(5-cyanopyrazin-2-yl)ureas as potent Chk1 kinase inhibitors.

Chang Park, Saul H Rosenberg, Gaoquan Li, 2006, Bioorganic & medicinal chemistry letters.

Chk1 Mediates S and G2 Arrests through Cdc25A Degradation in Response to DNA-damaging Agents*

A. Gunasekera, S. Fesik, Zehan Chen, 2003, Journal of Biological Chemistry.

Chk1 and Chk2 as Checkpoint Targets

Haiying Zhang, T. Sowin, Zhan Xiao, 2010 .

Chapter 16 Chk1 and Chk2 as Checkpoint Targets

Haiying Zhang, T. Sowin, Zhan Xiao, 2009 .

Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors.

P. Kovar, Zehan Chen, Haiying Zhang, 2006, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one-based potent and selective Chk-1 inhibitors.

Chang Park, John Xue, Saul H Rosenberg, 2007, Journal of medicinal chemistry.

Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor.

Haiying Zhang, S. Rosenberg, N. Lin, 2004, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 4-[(3-methyl-3H-imidazol-4-yl)-(2-phenylethynyl-benzyloxy)-methyl]-benzonitrile as novel farnesyltransferase inhibitor.

Haiying Zhang, N. Lin, H. Sham, 2003, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 4-[3-biphenyl-2-yl-1-hydroxy-1-(3-methyl-3H-imidazol-4-yl)-prop-2-ynyl]-1-yl-benzonitrile as novel farnesyltransferase inhibitor.

Haiying Zhang, N. Lin, H. Sham, 2003, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of 4'-(6,7-disubstituted-2,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-biphenyl-4-ol as potent Chk1 inhibitors.

Saul H Rosenberg, Philip J. Merta, Gaoquan Li, 2007, Bioorganic & medicinal chemistry letters.

Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: improving oral biovailability.

Philip J. Merta, Gaoquan Li, Z. Tao, 2007, Bioorganic & medicinal chemistry letters.

Discovery of 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-benzonitriles and 4'-(1,4-dihydro-indeno[1,2-c]pyrazol-3-yl)-pyridine-2'-carbonitriles as potent checkpoint kinase 1 (Chk1) inhibitors.

Philip J. Merta, Gaoquan Li, Z. Tao, 2007, Bioorganic & medicinal chemistry letters.

Human Chk1 expression is dispensable for somatic cell death and critical for sustaining G2 DNA damage checkpoint.

S. Fesik, S. Ng, Zehan Chen, 2003, Molecular cancer therapeutics.

1-(5-Chloro-2-alkoxyphenyl)-3-(5-cyanopyrazin-2-yl)ureas [correction of cyanopyrazi] as potent and selective inhibitors of Chk1 kinase: synthesis, preliminary SAR, and biological activities.

Gaoquan Li, P. Kovar, Zehan Chen, 2005, Journal of medicinal chemistry.

Antitumor Activity of Orally Bioavailable Farnesyltransferase Inhibitor, ABT-100, Is Mediated by Antiproliferative, Proapoptotic, and Antiangiogenic Effects in Xenograft Models

Haiying Zhang, N. Lin, H. Sham, 2005, Clinical Cancer Research.

A-432411, a novel indolinone compound that disrupts spindle pole formation and inhibits human cancer cell growth

Philip J. Merta, P. Kovar, Zehan Chen, 2005, Molecular Cancer Therapeutics.

Chk 1 Mediates S and G 2 Arrests through Cdc 25 A Degradation in Response to DNA-damaging Agents *

A. Gunasekera, S. Fesik, Zehan Chen, 2003 .

Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase–activated protein kinase 2 in mediating DNA damage–induced cell cycle arrest: implications for cancer therapy

Haiying Zhang, T. Sowin, Zhan Xiao, 2006, Molecular Cancer Therapeutics.

A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation

Haiying Zhang, T. Sowin, S. Rosenberg, 2005, Oncogene.

Investigation of novel 7,8-disubstituted-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-ones as potent Chk1 inhibitors.

Philip J. Merta, Magdalena Przytulinska, P. Kovar, 2008, Bioorganic & medicinal chemistry letters.

Novel indication for cancer therapy: Chk1 inhibition sensitizes tumor cells to antimitotics

Haiying Zhang, T. Sowin, S. Rosenberg, 2005, International journal of cancer.

A highly potent and selective farnesyltransferase inhibitor ABT-100 in preclinical studies

V. Stoll, T. Holzman, S. Muchmore, 2005, Anti-cancer drugs.

Pyridone-containing farnesyltransferase inhibitors: synthesis and biological evaluation.

Haiying Zhang, S. Rosenberg, N. Lin, 2003, Bioorganic & medicinal chemistry letters.

Design and synthesis of o-trifluoromethylbiphenyl substituted 2-amino-nicotinonitriles as inhibitors of farnesyltransferase.

Saul H Rosenberg, Haiying Zhang, T. Sowin, 2005, Bioorganic & medicinal chemistry letters.

Macrocyclic ureas as potent and selective Chk1 inhibitors: an improved synthesis, kinome profiling, structure-activity relationships, and preliminary pharmacokinetics.

Z. Tao, P. Kovar, Zehan Chen, 2007, Bioorganic & medicinal chemistry letters.

Structure-based design, synthesis, and biological evaluation of potent and selective macrocyclic checkpoint kinase 1 inhibitors.

Chang Park, Philip J. Merta, Z. Tao, 2007, Journal of medicinal chemistry.

Synthesis and biological evaluation of 3-ethylidene-1,3-dihydro-indol-2-ones as novel checkpoint 1 inhibitors.

Saul H. Rosenberg, Chang Park, P. Kovar, 2006, Bioorganic & medicinal chemistry letters.

Aryl tetrahydropyridine inhibitors of farnesyltransferase: bioavailable analogues with improved cellular potency.

V. Stoll, S. Muchmore, S. Ng, 2003, Bioorganic & medicinal chemistry letters.

Synthesis of 1H-pyridin-2-one derivatives as potent and selective farnesyltransferase inhibitors.

R. Henry, Haiying Zhang, S. Rosenberg, 2004, Bioorganic & medicinal chemistry letters.

Design, synthesis, and biological activity of 4-[(4-cyano-2-arylbenzyloxy)-(3-methyl-3H-imidazol-4-yl)methyl]benzonitriles as potent and selective farnesyltransferase inhibitors.

V. Stoll, Y. Tong, Haiying Zhang, 2004, Journal of medicinal chemistry.

Selective Chk1 inhibitors differentially sensitize p53‐deficient cancer cells to cancer therapeutics

Zhan Xiao, John Xue, Saul H Rosenberg, 2006, International journal of cancer.

Kinase Drug Discovery by Affinity Selection/Mass Spectrometry (ASMS): Application to DNA Damage Checkpoint Kinase Chk1

Hua Tang, Mark E Schurdak, Michael Coen, 2006, Journal of biomolecular screening.

Discovery of 1,4-dihydroindeno[1,2-c]pyrazoles as a novel class of potent and selective checkpoint kinase 1 inhibitors.

Chang Park, Saul H Rosenberg, Y. Tong, 2007, Bioorganic & medicinal chemistry.

Cyclin B1 is an efficacy-predicting biomarker for Chk1 inhibitors

Gaoquan Li, Z. Tao, Haiying Zhang, 2008 .

1,4-Dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: extended exploration on phenyl ring substitutions and preliminary ADME/PK studies.

Philip J. Merta, Z. Tao, Y. Tong, 2007, Bioorganic & medicinal chemistry letters.

Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability.

V. Stoll, Y. Tong, Haiying Zhang, 2003, Bioorganic & medicinal chemistry letters.