N. Gooderham

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Mechanisms of action of the carcinogenic heterocyclic amine PhIP.

N. Gooderham, S. Creton, S. Lauber, 2007, Toxicology letters.

A mechanistic basis for the role of cycle arrest in the genetic toxicology of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

N. Gooderham, S. Creton, H. Zhu, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I. Reports of individual databases presented at an EURL ECVAM Workshop.

Andrew Worth, Markus Schulz, Raffaella Corvi, 2014, Mutation research. Genetic toxicology and environmental mutagenesis.

The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine promotes invasive behaviour of breast cancer cells.

N. Gooderham, S. Lauber, Sandra N. Lauber, 2011, Toxicology.

The safety evaluation of food flavouring substances: the role of metabolic studies.

Sean V. Taylor, Christie L Harman, Samuel M. Cohen, 2018, Toxicology research.

Interaction of the transactivating protein HIV-1 tat with sulphated polysaccharides.

R. Edwards, D. Davies, N. Gooderham, 1999, Biochemical pharmacology.

FEMA expert panel review of p-mentha-1,8-dien-7-al genotoxicity testing results.

Sean V. Taylor, Christie L Harman, Samuel M. Cohen, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Assessment of temporal dose-toxicity relationship of fumed silica nanoparticle in human lung A549 cells by conventional cytotoxicity and ¹H-NMR-based extracellular metabonomic assays.

Michael Cauchi, James Njuguna, Huijun Zhu, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Polymorphisms in the cytochrome P450 CYP1A2 gene (CYP1A2) in colorectal cancer patients and controls: allele frequencies, linkage disequilibrium and influence on caffeine metabolism.

J. Barrett, A. Boobis, Gillian Smith, 2003, British journal of clinical pharmacology.

Early events in the mammalian response to DNA double-strand breaks.

N. Gooderham, A. Lynch, Lucy C. Riches, 2008, Mutagenesis.

Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype

A. Darzi, H. Ashrafian, T. Athanasiou, 2021, Microbiome.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

G. B. Gori, D. Dietrich, J. Hengstler, 2013, Toxicon : official journal of the International Society on Toxinology.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

G. B. Gori, D. Dietrich, J. Hengstler, 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

G. B. Gori, D. Dietrich, J. Hengstler, 2013, Chemico-biological interactions.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

G. B. Gori, D. Dietrich, J. Hengstler, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Open letter to the European commission: scientifically unfounded precaution drives European commission’s recommendations on EDC regulation, while defying common sense, well-established science, and risk assessment principles

G. B. Gori, D. Dietrich, J. Hengstler, 2013, Archives of Toxicology.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles

G. B. Gori, D. Dietrich, J. Hengstler, 2013 .

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

G. B. Gori, D. Dietrich, J. Hengstler, 2013, Toxicon : official journal of the International Society on Toxinology.

DNA damage responses after exposure to DNA‐based products

N. Gooderham, A. Lynch, M. Aylott, 2006, The journal of gene medicine.

FEMA GRAS assessment of natural flavor complexes: Mint, buchu, dill and caraway derived flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Mechanisms of Chemical Carcinogenesis

N. Gooderham, P. Carmichael, 2007 .

Experimental Bariatric Surgery in Rats Generates a Cytotoxic Chemical Environment in the Gut Contents

A. Darzi, H. Ashrafian, T. Athanasiou, 2011, Front. Microbio..

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control

Julian E. Fuchs, R. Glen, D. Gauguier, 2018, bioRxiv.

The mutagenic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine in Muta™Mouse colon is attenuated by resveratrol

N. Gooderham, R. David, A. Boyce, 2014 .

The selective cytotoxicity of the alkenyl glucosinolate hydrolysis products and their presence in Brassica vegetables.

N. Gooderham, J. Rossiter, R. David, 2015, Toxicology.

The cooked meat derived genotoxic carcinogen 2-amino-3-methylimidazo[4,5-b]pyridine has potent hormone-like activity: mechanistic support for a role in breast cancer.

N. Gooderham, S. Lauber, Sandra N. Lauber, 2007, Cancer research.

Interleukin-6 selectively induces drug metabolism to potentiate the genotoxicity of dietary carcinogens in mammary cells

N. Gooderham, R. David, Durr-e-shahwar Malik, 2019, Archives of Toxicology.

The non-genotoxic hepatocarcinogen Phenobarbital causes persistent changes in the expression of liver microRNAs in the male Fischer rat

C. Koufaris, N. Gooderham, Jayne Wright, 2010 .

Formation of a mutagenic heterocyclic aromatic amine from creatinine in urine of meat eaters and vegetarians.

B. Lake, N. Gooderham, Jason R. Taylor, 2005, Chemical research in toxicology.

PhIP induced deregulation of microRNA expression is consistent with its oestrogenic properties

N. Gooderham, M. Papaioannou, 2009 .

Interleukin-6 promotes dietary carcinogen-induced DNA damage in colorectal cancer cells

N. Gooderham, Saroor A. A. Patel, 2015 .

Interleukin-6 mediates crosstalk between immune and colorectal cancer cells via miR21 and miR29b

N. Gooderham, Saroor A. A. Patel, 2015 .

Infection by HIV‐1 blocked by binding of dextrin 2‐sulphate to the cell surface of activated human peripheral blood mononuclear cells and cultured T‐cells

R. Edwards, J. Weber, D. Davies, 1994, British journal of pharmacology.

FEMA GRAS assessment of natural flavor complexes: Clove, Cinnamon leaf and West Indian bay leaf-derived flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

FEMA GRAS assessment of natural flavor complexes: Lavender, Guaiac Coriander-derived and related flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

FEMA GRAS assessment of natural flavor complexes: Cinnamomum and Myroxylon-derived flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Improved hepatic physiology in hepatic cytochrome P450 reductase null (HRN™) mice dosed orally with fenclozic acid.

Alison J. Foster, I. Wilson, J. G. Kenna, 2017, Toxicology research.

2-Amino-l-methyl-6-phenylimidazo [ 4 , 5-Â £ ] pyridine Is a Potent Mutagen in the Mouse Small Intestine 1

Zhao, Douglas, R. Edwards, 2006 .

In vitro translational activity of messenger-RNA isolated from mice treated with the interferon inducer, polyriboinosinic acid.polyribocytidylic acid.

N. Gooderham, G. Mannering, 1990, Biochemical pharmacology.

Depression of cytochrome P-450 and alterations of protein metabolism in mice treated with the interferon inducer polyriboinosinic acid X polyribocytidylic acid.

N. Gooderham, G. Mannering, 1986, Archives of biochemistry and biophysics.

Depression of the hepatic cytochrome P-450 monooxygenase system by treatment of mice with the antineoplastic agent 5-azacytidine.

N. Gooderham, G. Mannering, G. J. Mannering, 1985, Cancer research.

Synergistic and Antagonistic Mutation Responses of Human MCL-5 Cells to Mixtures of Benzo[a]pyrene and 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]pyridine: Dose-Related Variation in the Joint Effects of Common Dietary Carcinogens

N. Gooderham, T. Ebbels, R. David, 2015, Environmental health perspectives.

The cellular toxicology of mitragynine, the dominant alkaloid of the narcotic-like herb, Mitragyna speciosa Korth

N. Gooderham, E. Holmes, H. Takayama, 2015 .

Post-operative atrial fibrillation is associated with a pre-existing structural and electrical substrate in human right atrial myocardium

A. Darzi, H. Ashrafian, T. Athanasiou, 2016, International journal of cardiology.

A comprehensive approach to the profiling of the cooked meat carcinogens 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, and their metabolites in human urine.

B. Lake, D. LeMaster, N. Gooderham, 2010, Chemical research in toxicology.

Biomonitoring of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and its carcinogenic metabolites in urine.

N. Gooderham, R. Turesky, AnupP Thakur, 2009, Chemical research in toxicology.

Cruciferous vegetable consumption alters the metabolism of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans.

D. G. Walters, A. Boobis, B. Lake, 2004, Carcinogenesis.

A triple-helix forming oligonucleotide targeting genomic DNA fails to induce mutation.

N. Gooderham, Reshat Reshat, Catherine C. Priestley, 2012, Mutagenesis.

Phytoalexin resveratrol attenuates the mutagenicity of the heterocyclic amines 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.

N. Gooderham, J. Doehmer, A. Boyce, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

S-Methyl-L-cysteine sulphoxide: the Cinderella phytochemical?

N. Gooderham, E. Holmes, W. Edmands, 2013 .

The safety evaluation of food flavoring substances: the role of genotoxicity studies

Sean V. Taylor, Samuel M. Cohen, S. Fukushima, 2020, Critical reviews in toxicology.

Abstract 5454: Genotoxic consequences of exposure to mixtures of food-derived chemical carcinogens

N. Gooderham, R. David, 2012 .

Mechanisms of Chemical Carcinogenesis

N. Gooderham, P. Carmichael, 2007 .

Rapid biomonitoring of heterocyclic aromatic amines in human urine by tandem solvent solid phase extraction liquid chromatography electrospray ionization mass spectrometry.

B. Lake, N. Gooderham, Jason R. Taylor, 2004, Chemical research in toxicology.

Distribution and Elimination of [14 C]2-Amino-3,8-dimethylimidazo-(4,5-F)quinoxaline

A. Boobis, D. Davies, N. Gooderham, 1988 .

The cooked meat carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine activates the extracellular signal regulated kinase mitogen-activated protein kinase pathway.

N. Gooderham, S. Creton, Hui-jun Zhu, 2007, Cancer research.

Extra-nuclear location of histones in activated human peripheral blood lymphocytes and cultured T-cells.

R. Edwards, D. Parmelee, D. Davies, 1995, Biochemical pharmacology.

Mutagenesis by an antisense oligonucleotide and its degradation product.

N. Gooderham, Reshat Reshat, Catherine C. Priestley, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Ethanol potentiates the genotoxicity of the food-derived mammary carcinogen PhIP in human estrogen receptor-positive mammary cells: mechanistic support for lifestyle factors (cooked red meat and ethanol) associated with mammary cancer

N. Gooderham, R. David, Durr-e-shahwar Malik, 2018, Archives of Toxicology.

Dextrin Sulphate and Fucoidan are Potent Inhibitors of HIV Infection in vitro

R. Keynes, R. Weiss, D. Davies, 1991 .

The Lack of Mutagenic Potential of a Guanine-Rich Triplex Forming Oligonucleotide in Physiological Conditions

L. Ying, N. Gooderham, A. F. Saleh, 2017, Toxicological sciences : an official journal of the Society of Toxicology.

Anti-HIV type 1 activity of sulfated derivatives of dextrin against primary viral isolates of HIV type 1 in lymphocytes and monocyte-derived macrophages.

R. Edwards, D. Davies, N. Gooderham, 1997, AIDS research and human retroviruses.

Organ distinctive mutagenicity in MutaMouse after short-term exposure to PhIP.

A. Boobis, N. Gooderham, A. Lynch, 1996, Mutagenesis.

2′-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells

N. Gooderham, S. Henry, A. F. Saleh, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Chemical methods for assessing systemic exposure to dietary heterocyclic amines in man.

A. Boobis, R. de la Torre, D. Davies, 1996, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Tumour necrosis factor-α (TNF-α) enhances dietary carcinogen-induced DNA damage in colorectal cancer epithelial cells through activation of JNK signaling pathway

N. Gooderham, Jia V. Li, Aminah Alotaibi, 2021, Toxicology.

Induction of xanthine oxidase and depression of cytochrome P-450 by interferon inducers: genetic difference in the responses of mice.

N. Gooderham, G. Mannering, L. Deloria, 1985, Biochemical and biophysical research communications.

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles.

D. Dietrich, J. Hengstler, W. Dekant, 2013, ALTEX.

GRASr2 evaluation of aliphatic acyclic and alicyclic terpenoid tertiary alcohols and structurally related substances used as flavoring ingredients.

Sean V. Taylor, Christie L Harman, L. Marnett, 2014, Journal of food science.

GRAS Flavoring Substances 25. The 25th publication by the Expert Panel of the Flavor and Extract Manufacturers Association provides an update on reent progress in the consideration of flavoring ingredients generally recognized as safe under the Food Additives Amendment

Sean V. Taylor, L. Marnett, S. Fukushima, 2011 .

Reevluation of the mutagenic response to phosphorothioate nucleotides in human lymphoblastoid TK 6 cells

N. Gooderham, A. F. Saleh, M. Fellows, 2015 .

GRAS 29 flavoring substances

Sean V. Taylor, Christie L Harman, S. Fukushima, 2020 .

Impact of structural and metabolic variations on the toxicity and carcinogenicity of hydroxy- and alkoxy-substituted allyl- and propenylbenzenes.

C. G. Harman, L. Marnett, S. Fukushima, 2014, Chemical research in toxicology.

GRAS flavoring substances 25

Robert L. Smith, Samuel Monroe Cohen, William J. Waddell, 2001 .

Dose-dependent synergistic and antagonistic mutation responses of binary mixtures of the environmental carcinogen benzo[a]pyrene with food-derived carcinogens

N. Gooderham, R. David, 2018, Archives of Toxicology.

p53 regulation of glycolytic enzymes

N. Gooderham, M. Papaioannou, 2008 .

The in vitro metabolism of N,N-dimethylaniline by guinea pig and rabbit tissue preparations

N. Gooderham, J. Gorrod, 2010, European Journal of Drug Metabolism and Pharmacokinetics.

Microsomal N- and C-oxidation of 4-substituted N-benzylanilines.

N. Gooderham, J. Gorrod, 1985, Xenobiotica; the fate of foreign compounds in biological systems.

Re-evaluation of the Mutagenic Response to Phosphorothioate Nucleotides in Human Lymphoblastoid TK6 Cells.

N. Gooderham, A. F. Saleh, M. Fellows, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

In vitro genotoxicity of the West African anti-malarial herbal Cryptolepis sanguinolenta and its major alkaloid cryptolepine.

N. Gooderham, Ayesha Khan, C. Ansah, 2005, Toxicology.

FEMA GRAS assessment of natural flavor complexes: Eucalyptus oil and other cyclic ether-containing flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

FEMA GRAS assessment of natural flavor complexes: Asafetida oil, garlic oil and onion oil.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

FEMA GRAS assessment of natural flavor complexes: Allspice, anise, fennel-derived and related flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

FEMA GRAS assessment of natural flavor complexes: Origanum oil, thyme oil and related phenol derivative-containing flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2021, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Updated procedure for the safety evaluation of natural flavor complexes used as ingredients in food.

Sean V. Taylor, F Peter Guengerich, Jeanne M. Davidsen, 2018, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Safety evaluation of substituted thiophenes used as flavoring ingredients.

Sean V. Taylor, Christie L Harman, S. Fukushima, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Identification of human urinary biomarkers of cruciferous vegetable consumption by metabonomic profiling.

B. Lake, J. Lindon, N. Gooderham, 2011, Journal of proteome research.

The effect of cruciferous vegetable dietary intervention on human urinary metabonomic profile

N. Gooderham, 2009 .

In silico and in vitro evaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization

Emma L. Koppe, T. Gant, N. Gooderham, 2015, Nucleic acids research.

Strategies for In Vivo Screening and Mitigation of Hepatotoxicity Associated with Antisense Drugs

T. Gant, J. Ridings, N. Gooderham, 2017, Molecular therapy. Nucleic acids.

N-hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver.

A. Boobis, D. Davies, N. Gooderham, 1992, Carcinogenesis.

Are differences in microRNA regulation implicated in species-dependent response to toxicological exposures?

C. Koufaris, N. Gooderham, 2013, Toxicological sciences : an official journal of the Society of Toxicology.

Advancing the use of noncoding RNA in regulatory toxicology: Report of an ECETOC workshop.

Jörg Hackermüller, Bruno Hubesch, Helmut Greim, 2016, Regulatory toxicology and pharmacology : RTP.

Elevated serum microRNA 483-5p levels may predict patients at risk of post-operative atrial fibrillation

A. Darzi, H. Ashrafian, T. Athanasiou, 2016, European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.

Increased MicroRNA Levels in Women With Polycystic Ovarian Syndrome but Without Insulin Resistance: A Pilot Prospective Study

S. Atkin, N. Gooderham, T. Sathyapalan, 2020, Frontiers in Endocrinology.

microRNA Expression in Women With and Without Polycystic Ovarian Syndrome Matched for Body Mass Index

S. Atkin, N. Gooderham, T. Sathyapalan, 2020, Frontiers in Endocrinology.

Improved physiology and metabolic flux after Roux-en-Y gastric bypass is associated with temporal changes in the circulating microRNAome: a longitudinal study in humans

A. Darzi, H. Ashrafian, T. Athanasiou, 2018, BMC Obesity.

The cooked food derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine is a potent oestrogen: a mechanistic basis for its tissue-specific carcinogenicity.

Simak Ali, N. Gooderham, S. Lauber, 2004, Carcinogenesis.

Mechanistic evidence that benzo[a]pyrene promotes an inflammatory microenvironment that drives the metastatic potential of human mammary cells

N. Gooderham, R. David, Durr-e-shahwar Malik, 2018, Archives of Toxicology.

Hepatic microRNA profiles offer predictive and mechanistic insights after exposure to genotoxic and epigenetic hepatocarcinogens.

C. Koufaris, N. Gooderham, Jayne Wright, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Expression of cyclooxygenase-2 parallels expression of interleukin-1beta, interleukin-6 and NF-kappaB in human colorectal cancer.

T. Lightfoot, N. Gooderham, C. Maihöfner, 2003, Carcinogenesis.

Tumour Necrosis Factor-Alpha (TNF-α)-Induced Metastatic Phenotype in Colorectal Cancer Epithelial Cells: Mechanistic Support for the Role of MicroRNA-21

N. Gooderham, Jia Li, Aminah G. Alotaibi, 2023, Cancers.

ACCELERATED PAPER: Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) at the Chinese hamster hprt locus

Alan R. Boobis, Nigel J. Gooderham, A. Boobis, 1996 .

Diet-induced metabolic changes of the human gut microbiome: importance of short-chain fatty acids, methylamines and indoles

N. Gooderham, A. Neves, M. Dumas, 2019, Acta Diabetologica.

Histones located on the plasma membrane of T-cells.

D. Parmelee, D. Davies, N. Gooderham, 1994, Biochemical Society transactions.

Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue

V. Speirs, T. Lightfoot, N. Gooderham, 2009, British Journal of Cancer.

IL6 Mediates Immune and Colorectal Cancer Cell Cross-talk via miR-21 and miR-29b

Nigel J Gooderham, N. Gooderham, Saroor A. A. Patel, 2015, Molecular Cancer Research.

Responses of genes involved in cell cycle control to diverse DNA damaging chemicals in human lung adenocarcinoma A549 cells

N. Gooderham, Catherine C Smith, C. Ansah, 2005, Cancer Cell International.

Cryptolepine Provokes Changes in the Expression of Cell Cycle Proteins in Growing Cells

N. Gooderham, C. Ansah, 2009 .

The food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine activates S-phase checkpoint and apoptosis, and induces gene mutation in human lymphoblastoid TK6 cells.

A. Boobis, N. Gooderham, H. Zhu, 2000, Cancer research.

Mechanisms of induction of cell cycle arrest and cell death by cryptolepine in human lung adenocarcinoma a549 cells.

N. Gooderham, Huijun Zhu, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

cryptolepine in human lung adenocarcinoma A549 cells

N. Gooderham, Huijun Zhu, Bedfordshire Mk, 2006 .

FEMA GRAS assessment of natural flavor complexes: Lemongrass oil, chamomile oils, citronella oil and related flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

FEMA GRAS assessment of derivatives of basil, nutmeg, parsley, tarragon and related allylalkoxybenzene-containing natural flavor complexes.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype

A. Darzi, H. Ashrafian, T. Athanasiou, 2021, Microbiome.

Bariatric Surgery Modulates Urinary Levels of MicroRNAs Involved in the Regulation of Renal Function

A. Darzi, H. Ashrafian, T. Athanasiou, 2019, Front. Endocrinol..

N. Gooderham, C. Ansah, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Metabolic surgery and cancer

A. Darzi, H. Ashrafian, T. Athanasiou, 2011, Cancer.

Molecular and genetic toxicology of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

N. Gooderham, S. Creton, S. Lauber, 2002, Mutation research.

The cooked meat-derived mammary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) elicits estrogenic-like microRNA responses in breast cancer cells.

C. Koufaris, N. Gooderham, M. Papaioannou, 2014, Toxicology letters.

Using microRNA profiles to predict and evaluate hepatic carcinogenic potential.

C. Koufaris, N. Gooderham, 2014, Toxicology letters.

Transdifferentiated rat pancreatic progenitor cells (AR42J-B13/H) respond to phenobarbital in a rat hepatocyte-specific manner.

N. Gooderham, R. Currie, M. Haltalli, 2016, Toxicology.

In vitro toxicology of extract of Mitragyna speciosa Korth, a malaysian phyto-pharmaceutical of abuse

N. Gooderham, N. Saidin, 2007 .

Pre-operative serum VCAM-1 as a biomarker of atrial fibrillation after coronary artery bypass grafting

A. Darzi, H. Ashrafian, T. Athanasiou, 2017, Journal of Cardiothoracic Surgery.

Neoplastic transformation of human lung fibroblast MRC-5 SV2 cells induced by benzo[a]pyrene and confluence culture.

N. Gooderham, Huijun Zhu, 2002, Cancer research.

GRAS 28 flavoring substances

Sean V. Taylor, Christie L Harman, S. Fukushima, 2018 .

Using 3D MCF-7 mammary spheroids to assess the genotoxicity of mixtures of the food-derived carcinogens benzo[a]pyrene and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

N. Gooderham, R. David, 2016, Toxicology research.

Systemic exposure to dietary heterocyclic amines in man.

A. Boobis, R. de la Torre, D. Davies, 1995, Princess Takamatsu symposia.

Nucleosomes Bind to Cell Surface Proteoglycans*

R. Edwards, D. Davies, N. Gooderham, 1999, The Journal of Biological Chemistry.

Metabolic phenotype-microRNA data fusion analysis of the systemic consequences of Roux-en-Y gastric bypass surgery

A. Darzi, H. Ashrafian, T. Athanasiou, 2015, International Journal of Obesity.

Abstract 6: A triple-helix forming oligonucleotide targeting a genomic locus is capable of sequence specific mutagenesis in human lymphoblastoid TK6 cells

N. Gooderham, Reshat Reshat, Catherine C. Priestley, 2010 .

Tyramine promotes colon cancer risk and development by inducing DNA damage and inflammation

N. Gooderham, M. El-Bahrawy, M. Glymenaki, 2023, bioRxiv.

Time and dose-dependent effects of phenobarbital on the rat liver miRNAome.

C. Koufaris, N. Gooderham, Jayne Wright, 2013, Toxicology.

Improved Preparation of α,N‐Diphenylnitrones and N‐Benzyl‐N‐Phenylhydroxylamines by direct Oxidation of Secondary Anilines

N. Gooderham, J. Gorrod, 1986 .

The metabolism of N-benzyl-4-substituted anilines: factors influencing in vitro C- and N-oxidation.

N. Gooderham, J. Gorrod, 1987, Xenobiotica; the fate of foreign compounds in biological systems.

Improved Preparation of α,N-Diphenylnitrones and N-Benzyl-N-phenylhydroxylamines by Direct Oxidation of Secondary Anilines.

N. Gooderham, J. Gorrod, 1986 .

IL 6 Mediates Immune and Colorectal Cancer Cell Cross-talk via miR-21 and miR-29 b

N. Gooderham, Saroor A. A. Patel, 2015 .

G. B. Gori, D. Dietrich, J. Hengstler, 2013, Archives of Toxicology.

Increased expression of circulating miRNA-93 in women with polycystic ovary syndrome may represent a novel, non-invasive biomarker for diagnosis

S. Atkin, N. Gooderham, T. Sathyapalan, 2015, Scientific Reports.

Effects of treatment with androgen receptor ligands on microRNA expression of prostate cancer cells.

C. Powell, C. Koufaris, N. Gooderham, 2015, Toxicology.

Correction: Aspartame Sensitivity? A Double Blind Randomised Crossover Study

A. Rigby, R. Hammersley, S. Atkin, 2015, PloS one.

Aspartame Sensitivity? A Double Blind Randomised Crossover Study

A. Rigby, R. Hammersley, S. Atkin, 2015, PloS one.

Interleukin-6 mediated upregulation of CYP1B1 and CYP2E1 in colorectal cancer involves DNA methylation, miR27b and STAT3

R. Edwards, A. Boobis, T. Lightfoot, 2014, British Journal of Cancer.

A molecular beacon approach to detecting RAD52 expression in response to DNA damage in human cells.

N. Gooderham, A. Lynch, Lucy C. Riches, 2010, Toxicology in vitro : an international journal published in association with BIBRA.

FEMA GRAS assessment of natural flavor complexes: Sage oil, Orris Root Extract and Tagetes Oil and related flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Food-derived heterocyclic amine mutagens: variable metabolism and significance to humans.

A. Boobis, D. Davies, N. Gooderham, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue

V. Speirs, T. Lightfoot, K. Horgan, 2009, British Journal of Cancer.

Intra- and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl- 6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef.

A. Boobis, D. Davies, N. Gooderham, 1992, Cancer research.

Effect of cruciferous vegetable consumption on heterocyclic aromatic amine metabolism in man.

A. Boobis, B. Lake, N. Gooderham, 2001, Carcinogenesis.

Metabolism of the food derived mutagen and carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) by human liver microsomes.

A. Boobis, D. Davies, N. Gooderham, 1994, Carcinogenesis.

Detection and measurement of MeIQx in human urine after ingestion of a cooked meat meal.

A R Boobis, A. Boobis, D. Davies, 1989, Carcinogenesis.

CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans.

A. Boobis, R. de la Torre, M. Farré, 1994, Cancer research.

FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

The mutagenicity of benzo[a]pyrene in mouse small intestine.

R. Edwards, A. Boobis, D. Winton, 1999, Carcinogenesis.

Mutagenesis of mouse intestine in vivo using the Dlb-1 specific locus test: studies with 1,2-dimethylhydrazine, dimethylnitrosamine, and the dietary mutagen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.

B. Ponder, A. Boobis, D. Winton, 1990, Cancer research.

Using miRNA ‘fingerprints’ to investigate androgen-mediated phenotypic change

N. Gooderham, C. Powell, Corrinne V. Segal, 2011 .

Distribution and Elimination of [2-14C]Amino-3, 8-Dimethylimidazo [4, 5-f] quinoxaline in Mice. Analysis by Whole Animal Autoradiography

A. Boobis, D. Davies, N. Gooderham, 1991, Human & experimental toxicology.

Multivariate modelling analysis for prediction of glycidyl esters and 3-monochloropropane-1,2-diol (3-MCPD) formation in periodically heated palm oil

N. Gooderham, M. Maulidiani, Tengku Rozaina Tengku Mohamad, 2023, Heliyon.

IL6 Mediates Immune and Colorectal Cancer Cell Cross-talk via miR-21 and miR-29b

N. Gooderham, Saroor A. A. Patel, 2015, Molecular Cancer Research.

Dose-dependent synergistic and antagonistic mutation responses of binary mixtures of the environmental carcinogen benzo[a]pyrene with food-derived carcinogens

N. Gooderham, R. David, 2018, Archives of Toxicology.

In vitro toxicology of 2-propenyl and 3-butenyl glucosinolate derivatives

N. Gooderham, J. Rossiter, N. A. Kadir, 2009 .

Investigation of interaction between N-acetyltransferase 2 and heterocyclic amines as potential risk factors for colorectal cancer.

R C Garner, J. Barrett, D. Forman, 2003, Carcinogenesis.