G. Taucher‐Scholz

发表

Accumulation of the Cell Cycle Regulators TP53 and CDKN1A (p21) in Human Fibroblasts after Exposure to Low- and High-LET Radiation

C. Fournier, C. Wiese, G. Taucher‐Scholz, 2004, Radiation research.

Live Cell Imaging to Study Real-Time ATM-Mediated Recruitment of DNA Repair Complexes to Sites of Ionizing Radiation-Induced DNA Damage.

G. Taucher‐Scholz, B. Jakob, 2017, Methods in molecular biology.

Radiation induced cell cycle arrest: an overview of specific effects following high-LET exposure.

C. Fournier, G. Taucher‐Scholz, 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Live Cell Imaging of Heavy-Ion-Induced Radiation Responses by Beamline Microscopy

N. Gueven, M. Lavin, G. Taucher‐Scholz, 2005, Radiation research.

Factors determining DNA double‐strand break repair pathway choice in G2 phase

Markus Löbrich, Olivia Barton, A. Shibata, 2011, The EMBO journal.

Spatiotemporal analysis of DNA repair using charged particle radiation.

M. Durante, G. Taucher‐Scholz, B. Jakob, 2010, Mutation research.

Immediate Localized CDKN1A (p21) Radiation Response after Damage Produced by Heavy-Ion Tracks

G. Taucher‐Scholz, B. Jakob, M. Scholz, 2000, Radiation research.

Nanolesions induced by heavy ions in human tissues: Experimental and theoretical studies

M. Durante, G. Taucher‐Scholz, F. Natale, 2012, Beilstein journal of nanotechnology.

Direct visualisation of heavy ion induced DNA fragmentation using atomic force microscopy.

M. Heiss, R. Neumann, G. Taucher‐Scholz, 2004, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

A track structure model for simulation of strand breaks in plasmid DNA after heavy ion irradiation

G. Taucher‐Scholz, G. Kraft, M. Scholz, 2003, Radiation and environmental biophysics.

Measurement of intracellular dna double-strand break induction and rejoining along the track of carbon and neon particle beams in water.

G. Taucher‐Scholz, T. Haberer, G. Kraft, 1996, International journal of radiation oncology, biology, physics.

Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

Burkhard Jakob, Gisela Taucher-Scholz, David J. Chen, 2007, The Journal of cell biology.

Application of the local effect model to predict DNA double-strand break rejoining after photon and high-LET irradiation.

M. Durante, G. Taucher‐Scholz, M. Scholz, 2015, Radiation protection dosimetry.

Direct measurements of DNA fragmentation induced by heavy ions

M. Heiss, G. Taucher‐Scholz, E. Gudowska-Nowak, 2004 .

Influence of radiation quality on the yield of DNA strand breaks in SV40 DNA irradiated in solution.

G. Taucher‐Scholz, G. Kraft, 1999, Radiation research.

SFM studies of carbon ion induced damages in plasmid DNA

G. Taucher‐Scholz, F. Träger, F. Hubenthal, 2007, Journal of molecular recognition : JMR.

Different mechanisms of cell death in radiosensitive and radioresistant p53 mutated head and neck squamous cell carcinoma cell lines exposed to carbon ions and x-rays.

M. Beuve, C. Fournier, G. Taucher‐Scholz, 2009, International journal of radiation oncology, biology, physics.

A Calcium imaging setup at the single ion hit facility at GSI and its application to the investigation of Calcium response to ion irradiation in mammalian cells

P. Barberet, M. Heiss, G. Taucher‐Scholz, 2008 .

The Absence of an Early Calcium Response to Heavy-Ion Radiation in Mammalian Cells

G. Taucher‐Scholz, G. Kraft, G. Thiel, 2008, Radiation research.

P. Barberet, M. Heiss, C. Fournier, 2007, Radiation research.

Distribution of Double-Strand Breaks Induced by Ionizing Radiation at the Level of Single DNA Molecules Examined by Atomic Force Microscopy

G. Taucher‐Scholz, E. Gudowska-Nowak, K. Psonka-Antonczyk, 2009, Radiation research.

Nanoscale analysis of clustered DNA damage after high-LET irradiation by quantitative electron microscopy--the heavy burden to repair.

G. Taucher‐Scholz, C. Rübe, B. Jakob, 2015, DNA repair.

Clustered double-strand breaks in heterochromatin perturb DNA repair after high linear energy transfer irradiation.

G. Taucher‐Scholz, C. Rübe, B. Jakob, 2016, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Induction of DNA breaks in SV40 by heavy ions.

G. Taucher‐Scholz, G. Kraft, J. Stanton, 1992, Advances in space research : the official journal of the Committee on Space Research.

DNA Damage after High-LET Exposure

M. Löbrich, G. Taucher‐Scholz, A. Krempler, 2006 .

PCNA-dependent accumulation of CDKN1A into nuclear foci after ionizing irradiation.

C. Blattner, C. Wiese, G. Taucher‐Scholz, 2012, DNA repair.

Characterization of CDKN1A (p21) binding to sites of heavy-ion-induced damage: colocalization with proteins involved in DNA repair

G. Taucher‐Scholz, B. Jakob, M. Scholz, 2002, International journal of radiation biology.

Combination of static-field gel electrophoresis and densitometric scanning for the determination of radiation-induced DNA double-strand breaks in CHO cells

G. Taucher‐Scholz, G. Kraft, J. Heilmann, 1994, Radiation and environmental biophysics.

Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture.

G. Taucher‐Scholz, C. Rübe, B. Jakob, 2018, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Autophosphorylation and ATM activation: Additional sites add to the complexity

Keiji Suzuki, M. Lavin, G. Taucher‐Scholz, 2010 .

Fig S1. Expression and Localization of Gfp-aprataxin and Gfp-mdc1 in Unirradiated Cells. A. Expression of Gfp-aprataxin in Hela Cells. B. Expression of Gfp-mdc1 in Mdc1 -/-mefs. Nuclei Were Counterstained with Dapi

S. Smerdon, Junjie Chen, N. Gueven, 2022 .

Increased effectiveness of carbon ions in the production of reactive oxygen species in normal human fibroblasts

M. Durante, C. Fournier, G. Taucher‐Scholz, 2014, Journal of radiation research.

DNA strand break induction and rejoining and cellular recovery in mammalian cells after heavy-ion irradiation.

G. Taucher‐Scholz, G. Kraft, J. Heilmann, 1993, Radiation research.

The Ubiquitin Ligase RNF138 Cooperates with CtIP to Stimulate Resection of Complex DNA Double-Strand Breaks in Human G1-Phase Cells

M. Durante, N. Averbeck, G. Taucher‐Scholz, 2022, Cells.

Microscopic visualization of a biological response to charged particle traversal

G. Taucher‐Scholz, B. Jakob, M. Scholz, 2003 .

Direct Evidence for the Spatial Correlation between Individual Particle Traversals and Localized CDKN1A (p21) Response Induced by High-LET Radiation

G. Taucher‐Scholz, B. Jakob, H. Rothard, 2001, Radiation research.

Induction and rejoining of DNA double-strand breaks in CHO cells after heavy ion irradiation.

G. Taucher‐Scholz, G. Kraft, J. Heilmann, 1996, Advances in space research : the official journal of the Committee on Space Research.

Detection of heavy-ion-induced DNA double-strand breaks using static-field gel electrophoresis

G. Taucher‐Scholz, G. Kraft, J. Heilmann, 1995, Radiation and environmental biophysics.

Induction of DNA double-strand breaks in CHO-K1 cells by carbon ions.

G. Taucher‐Scholz, G. Kraft, J. Heilmann, 1995, International journal of radiation biology.

Tissue slice cultures from humans or rodents: a new tool to evaluate biological effects of heavy ions

H. Stöcker, M. Durante, I. Bechmann, 2010, Radiation and environmental biophysics.

The histone H2AX does not inhibit resection of DNA double strand breaks induced by heavy ions

M. Durante, N. Averbeck, G. Taucher‐Scholz, 2013 .

Positional Stability of Damaged Chromatin Domains along Radiation Tracks in Mammalian Cells

G. Taucher‐Scholz, B. Jakob, J. Splinter, 2009, Radiation research.

Interaction of heavy ions with nuclear chromatin: Spatiotemporal investigations of biological responses in a cellular environment

G. Taucher‐Scholz, B. Jakob, 2006 .

Recruitment of mRFP-XRCC1 to DNA damage in living cells

M. Durante, N. Averbeck, G. Taucher‐Scholz, 2009 .

Induction of DNA strand breaks by heavy ions

G. Taucher‐Scholz, G. Kraft, J. Heilmann, 1996 .

Impact of Charged Particle Exposure on Homologous DNA Double-Strand Break Repair in Human Blood-Derived Cells

D. Kraft, L. Wiesmüller, C. Fournier, 2015, Front. Oncol..

Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription.

N. Gueven, V. Schreiber, M. Lavin, 2006, Human molecular genetics.

Heavy ion microprobes: a unique tool for bystander research and other radiobiological applications

C. Fournier, G. Taucher‐Scholz, K. Voss, 2008 .

Comparison Between Indirect and Direct Effects for High and Low LET Radiations in SV40 DNA Strand Break Induction

G. Taucher‐Scholz, G. Kraft, J. Stanton, 1990 .

The link between cell-cycle dependent radiosensitivity and repair pathways: a model based on the local, sister-chromatid conformation dependent switch between NHEJ and HR.

M. Durante, G. Taucher‐Scholz, M. Scholz, 2015, DNA repair.

A DNA Double-Strand Break Kinetic Rejoining Model Based on the Local Effect Model

M. Durante, G. Taucher‐Scholz, M. Scholz, 2013, Radiation research.

DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin

Marco Durante, Burkhard Jakob, Daniele Zink, 2011, Nucleic acids research.

Requirement for PARP-1 in the recruitment of aprataxin to sites of DNA breaks

M. Durante, M. Lavin, G. Taucher‐Scholz, 2010 .

Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments

H. Stöcker, M. Durante, J. Meixensberger, 2013, Neuro-oncology.

CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response

S. Smerdon, Junjie Chen, N. Gueven, 2009, Nucleic acids research.

Aprataxin, a novel protein that protects against genotoxic stress.

Osamu Onodera, Gisela Taucher-Scholz, Hidetoshi Date, 2004, Human molecular genetics.

Comparison of the effects of carbon ion and photon irradiation on the angiogenic response in human lung adenocarcinoma cells.

W. Seeger, C. Fournier, G. Taucher‐Scholz, 2011, International journal of radiation oncology, biology, physics.

ATM Alters the Otherwise Robust Chromatin Mobility at Sites of DNA Double-Strand Breaks (DSBs) in Human Cells

M. Durante, G. Taucher‐Scholz, B. Jakob, 2014, PloS one.

Ion Irradiation as a Tool to Reveal the Spatiotemporal Dynamics of DNA Damage Response Processes

G. Taucher‐Scholz, B. Jakob, 2006 .

Identification of the elementary structural units of the DNA damage response

M. Durante, H. Leonhardt, M. C. Cardoso, 2017, Nature Communications.

Biological Imaging of Heavy Charged-Particle Tracks

M Scholz, G. Taucher‐Scholz, B. Jakob, 2003, Radiation research.

ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1

L. Wiesmüller, M. Gatei, K. Khanna, 2015, Nucleic acids research.

ATM Protein-dependent Phosphorylation of Rad50 Protein Regulates DNA Repair and Cell Cycle Control*

T. Dörk, M. Gatei, N. Gueven, 2011, The Journal of Biological Chemistry.

Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK

M. Durante, G. Taucher‐Scholz, B. Jakob, 2013, Nucleic acids research.

Autophosphorylation and ATM Activation

Keiji Suzuki, M. Lavin, G. Taucher‐Scholz, 2010, The Journal of Biological Chemistry.

Differential Repair Protein Recruitment at Sites of Clustered and Isolated DNA Double-Strand Breaks Produced by High-Energy Heavy Ions

M. Durante, G. Taucher‐Scholz, B. Jakob, 2020, Scientific Reports.

Spatiotemporal Dynamics of Early DNA Damage Response Proteins on Complex DNA Lesions

B. Drossel, M. Durante, G. Taucher‐Scholz, 2013, PloS one.

Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase

David J. Chen, A. Davis, G. Taucher‐Scholz, 2015, Nucleic acids research.

EXTENDED ABSTRACTS Proceedings of the 5th International Workshop: Microbeam Probes of Cellular Radiation Response

G. Taucher‐Scholz, 2019 .

Targeted Irradiation of Mammalian Cells Using a Heavy-Ion Microprobe

Burkhard Jakob, Claudia Fournier, Gisela Taucher-Scholz, 2006, Radiation research.

Biological dose estimation of UVA laser microirradiation utilizing charged particle-induced protein foci.

S W Hell, S. Hell, M. Durante, 2010, Mutagenesis.

Live cell microscopy analysis of radiation-induced DNA double-strand break motion

M. Durante, G. Taucher‐Scholz, B. Jakob, 2009, Proceedings of the National Academy of Sciences.

The GSI Heavy Ion Microbeam: A Tool for the Investigation of Cellular Response to High LET Radiations

P. Barberet, M. Heiss, G. Taucher‐Scholz, 2006 .

Tumor cell migration is not influenced by p21 in colon carcinoma cell lines after irradiation with X-ray or 12C heavy ions

G. Taucher‐Scholz, W. Mueller‐Klieser, M. Scholz, 2010, Radiation and environmental biophysics.

The impact of conventional and heavy ion irradiation on tumor cell migration in vitro

G. Taucher‐Scholz, W. Mueller‐Klieser, M. Scholz, 2007, International journal of radiation biology.

p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation

M. Beuve, C. Fournier, G. Taucher‐Scholz, 2013, BMC Cancer.

p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation

Claudia Fournier, Gisela Taucher-Scholz, Dominique Ardail, 2013, BMC Cancer.

Species conserved DNA damage response at the inactive human X chromosome.

M. Durante, N. Averbeck, Iris Müller, 2013, Mutation research.

Application of Fluorescence Lifetime Imaging Microscopy of DNA Binding Dyes to Assess Radiation-Induced Chromatin Compaction Changes

G. Taucher‐Scholz, B. Jakob, E. Abdollahi, 2018, International journal of molecular sciences.

Upgrading the GSI beamline microscope with a confocal fluorescence lifetime scanner to monitor charged particle induced chromatin decondensation in living cells

M. Durante, G. Taucher‐Scholz, B. Jakob, 2015 .

Photobleaching setup for the biological end-station of the darmstadt heavy-ion microprobe

C. Trautmann, M. Durante, G. Taucher‐Scholz, 2013 .

DNA end resection is needed for the repair of complex lesions in G1-phase human cells

M. Durante, N. Averbeck, G. Taucher‐Scholz, 2014, Cell cycle.

Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage.

Burkhard Jakob, Gisela Taucher-Scholz, G. Dianov, 2009, Human molecular genetics.

Efficient Rejoining of DNA Double-Strand Breaks despite Increased Cell-Killing Effectiveness following Spread-Out Bragg Peak Carbon-Ion Irradiation

M. Durante, N. Averbeck, G. Taucher‐Scholz, 2016, Front. Oncol..

Distribution of DNA fragment sizes after irradiation with ions

G. Taucher‐Scholz, K. Weron, E. Gudowska-Nowak, 2009, The European physical journal. E, Soft matter.

Carbon ion radiotherapy of human lung cancer attenuates HIF‐1 signaling and acts with considerably enhanced therapeutic efficiency

W. Seeger, J. Dahm-Daphi, C. Fournier, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Identification of the gene for DNA helicase II of Escherichia coli.

G. Taucher‐Scholz, H. Hoffmann-Berling, 1983, European journal of biochemistry.

Identification of Escherichia coli DNA helicase I as the traI gene product of the F sex factor.

G. Taucher‐Scholz, M. Klinkert, M. Abdel-monem, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Functions of DNA helicases in the DNA metabolism of Escherichia coli.

G. Taucher‐Scholz, A. Seiter, H. Hoffmann-Berling, 1984, Advances in experimental medicine and biology.

Heavy ion production of single- and double-strand breaks in plasmid DNA in aqueous solution.

G. Taucher‐Scholz, B. Jakob, G. Kraft, 2001, Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics.

Ionizing radiation-induced fragmentation of plasmid DNA Atomic force microscopy and biophysical modeling

M. Heiss, G. Taucher‐Scholz, E. Gudowska-Nowak, 2007 .

Induction of DNA damage by heavy ions measured by atomic force microscopy

M. Heiss, G. Taucher‐Scholz, E. Gudowska-Nowak, 2005 .

Radiation-induced base damage – FPG-sensitive sites in plasmid DNA

G. Taucher‐Scholz, E. Gudowska-Nowak, K. Psonka, 2008 .

Three-dimensional invasion of human glioblastoma cells remains unchanged by X-ray and carbon ion irradiation in vitro.

G. Schackert, G. Taucher‐Scholz, N. Cordes, 2012, International journal of radiation oncology, biology, physics.

NF-κB-dependent DNA damage-signaling differentially regulates DNA double-strand break repair mechanisms in immature and mature human hematopoietic cells

D. Kraft, L. Wiesmüller, C. Fournier, 2015, Leukemia.

Impact of carbon ion irradiation on epidermal growth factor receptor signaling and glioma cell migration in comparison to conventional photon irradiation

G. Taucher‐Scholz, N. Cordes, J. Roth, 2013, International journal of radiation biology.

Protection of DNA from high LET radiation by two OH radical scavengers, tris (hydroxymethyl) aminomethane and 2-mercaptoethanol

G. Taucher‐Scholz, G. Kraft, J. Heilmann, 1993, Radiation and environmental biophysics.

No Evidence for DNA and Early Cytogenetic Damage in Bystander Cells after Heavy-Ion Microirradiation at Two Facilities

P. Barberet, T. Pouthier, C. Fournier, 2009, Radiation research.

- 147-CDKN 1 A focus formation in mammalian cell nuclei at sites of particle traversal and association with repair or signaling proteins

H. Rodemann, K. Weber, G. Taucher‐Scholz, 2001 .

Differential Repair Protein Recruitment at Sites of Clustered and Isolated DNA Double-Strand Breaks Produced by High-Energy Heavy Ions

M. Durante, G. Taucher‐Scholz, B. Jakob, 2020, Scientific Reports.

Compound Poisson Statistics and Models of Clustering of Radiation Induced DNA Double Strand Breaks

G. Taucher‐Scholz, G. Kraft, E. Gudowska-Nowak, 2000, physics/0011071.

Live cell microscopy analysis of radiation-induced DNA double-strand break motion

G. Taucher‐Scholz, B. Jakob, J. Splinter, 2009, Proceedings of the National Academy of Sciences.

Live Cell Observations : Velocity of NBS 1 Recruitment to DNA Double Strand Breaks Does Not Depend on Ku 80 or 53 BP 1

M. Durante, N. Averbeck, G. Taucher‐Scholz, 2011 .

Spatiotemporal analysis of DNA repair using charged particle radiation.

G. Taucher‐Scholz, B. Jakob, F. Tobias, 2010, Mutation research.

Reduced contribution of thermally labile sugar lesions to DNA double strand break formation after exposure to heavy ions

G. Taucher‐Scholz, G. Iliakis, B. Jakob, 2013, Radiation oncology.

Reduced contribution of thermally labile sugar lesions to DNA double strand break formation after exposure to heavy ions

G. Taucher‐Scholz, G. Iliakis, B. Jakob, 2012, Radiation Oncology.