S. Chada

S. Chada, E. Grimm, S. Ekmekcioglu, 2006, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Ovarian cancer targeted adenoviral-mediated mda-7/IL-24 gene therapy.

P. Fisher, P. Dent, D. Curiel, 2006, Gynecologic oncology.

Multicenter phase I study of repeated intratumoral delivery of adenoviral p53 in patients with advanced non-small-cell lung cancer.

H. Kato, S. Kanazawa, T. Fujiwara, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Adenoviral-mediated mda-7 expression suppresses DNA repair capacity and radiosensitizes non-small-cell lung cancer cells

M. Story, S. Chada, R. Meyn, 2004, Oncogene.

Phosphatase and tensin analog gene overexpression engenders cellular death in human malignant mesothelioma cells via inhibition of AKT phosphorylation

Imran T. Mohiuddin, S. Chada, L. Zumstein, 2002, Annals of Surgical Oncology.

Sindbis virus DNA-based expression vectors: utility for in vitro and in vivo gene transfer

S. Chang, T. Banks, T. Dubensky, 1996, Journal of virology.

Inhibition of Src kinase activity by Ad-mda7 suppresses vascular endothelial growth factor expression in prostate carcinoma cells.

S. Inoue, R. Ramesh, S. Chada, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Phase II trial of patients (pts) with extensive stage small cell lung cancer (ES-SCLC) immunized with p53-transduced dendritic cells (p53-DC): Immune sensitization to chemotherapy (CT)

S. Chada, D. Gabrilovich, S. Antonia, 2007 .

An effective immunization and cancer treatment with activated dendritic cells transduced with full-length wild-type p53

J. Roth, S. Chada, B. Fang, 2002, Gene Therapy.

Gene therapy. Therapeutic approaches and implications.

R. Ramesh, A. Mhashilkar, S. Chada, 2001, Biotechnology advances.

Clinical and local biological effects of an intratumoral injection of mda-7 (IL24; INGN 241) in patients with advanced carcinoma: a phase I study.

Yuan Zhang, N. Senzer, J. Nemunaitis, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Biomarkers Predict p53 Gene Therapy Efficacy in Recurrent Squamous Cell Carcinoma of the Head and Neck

J. Roth, J. Baselga, M. Olivier, 2009, Clinical Cancer Research.

Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR.

K. Hunt, J. Roth, S. Swisher, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Negative association of melanoma differentiation-associated gene (mda-7) and inducible nitric oxide synthase (iNOS) in human melanoma: MDA-7 regulates iNOS expression in melanoma cells.

L. Broemeling, A. Mhashilkar, S. Chada, 2003, Molecular cancer therapeutics.

MDA-7/IL-24 suppresses human ovarian carcinoma growth in vitro and in vivo

R. Ramesh, B. Gopalan, S. Chada, 2007, Molecular Cancer.

Adenovirus-Mediated Gene Expression Radiosensitizes Non-Small Cell Lung Cancer Cells via -Independent Mechanisms

J. Roth, S. Chada, R. Meyn, 2002 .

Inhibition of human lung cancer growth following adenovirus-mediated mda-7 gene expression in vivo

J. Roth, R. Ramesh, A. Mhashilkar, 2002, Oncogene.

Melanoma differentiation-associated gene 7/interleukin (IL)-24 is a novel ligand that regulates angiogenesis via the IL-22 receptor.

R. Ramesh, J. Renauld, F. Tanaka, 2003, Cancer research.

Activation of the Fas-FasL signaling pathway by MDA-7/IL-24 kills human ovarian cancer cells.

R. Ramesh, B. Gopalan, A. Mhashilkar, 2005, Cancer research.

Tumor-suppressive effects by adenovirus-mediated mda-7 gene transfer in non-small cell lung cancer cell in vitro

J. Roth, R. Ramesh, A. Mhashilkar, 2000, Gene Therapy.

Adenovirus-mediated mda-7 gene expression radiosensitizes non-small cell lung cancer cells via TP53-independent mechanisms.

J. Roth, S. Chada, R. Meyn, 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

Adenoviral Transfer of mda-7 Leads to BAX Up-regulation and Apoptosis in Mesothelioma Cells, and is Abrogated by Over-expression of BCL-XL

D. McConkey, A. Mhashilkar, S. Chada, 2002, Molecular medicine.

Direct synovial gene transfer with retroviral vectors in rat adjuvant arthritis.

G. Firestein, S. Chada, D. Boyle, 1998, The Journal of rheumatology.

MDA-7/IL-24 as a Multi-Modality Therapy for Cancer

K. Hunt, S. Inoue, J. Roth, 2007 .

Antigen presentation in retroviral vector-mediated gene transfer in vivo.

S. Chada, V. Lee, C. Surh, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Local and Systemic Inhibition of Lung Tumor Growth After Nanoparticle-Mediated mda-7/IL-24 Gene Delivery

J. Roth, R. Ramesh, Yuji Saito, 2004 .

Human interleukin 24 (MDA-7/IL-24) protein kills breast cancer cells via the IL-20 receptor and is antagonized by IL-10

K. Hunt, R. Ramesh, A. Mhashilkar, 2006, Cancer Immunology, Immunotherapy.

Analysis of Adenoviral p53 Gene Therapy Clinical Trials in Recurrent Head and Neck Squamous Cell Carcinoma

J. Nemunaitis, S. Chada, D. Wiederhold, 2021, Frontiers in Oncology.

Tp53 gene therapy for cancer treatment and prevention

J. Roth, S. Swisher, J. Nemunaitis, 2013 .

Enhancement of adenoviral MDA-7-mediated cell killing in human lung cancer cells by geldanamycin and its 17-allyl- amino-17-demethoxy analogue

K. Hunt, J. Roth, S. Swisher, 2007, Cancer Gene Therapy.

by selenium in the HL-60 human myeloid cell line Post-transcriptional regulation of glutathione peroxidase gene expression

P. Newburger, S. Chada, C. Whitney, 2011 .

Post-transcriptional regulation of glutathione peroxidase gene expression by selenium in the HL-60 human myeloid cell line.

P. Newburger, S. Chada, C. Whitney, 1989, Blood.

Alveolar macrophages inhibit retrovirus-mediated gene transfer to airway epithelia.

B. Davidson, S. Chada, J. Kline, 1997, Human gene therapy.

Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer.

S. Inoue, J. Roth, R. Ramesh, 2005, Molecular cancer therapeutics.

Adenoviral endoplasmic reticulum–targeted mda-7/interleukin-24 vector enhances human cancer cell killing

K. Hunt, J. Roth, S. Swisher, 2008, Molecular Cancer Therapeutics.

Direct injection of a recombinant retroviral vector induces human immunodeficiency virus-specific immune responses in mice and nonhuman primates

S. Chada, V. Lee, D. Jolly, 1994, Journal of virology.

MDA-7/IL-24, a novel tumor suppressor/cytokine is ubiquitinated and regulated by the ubiquitin–proteasome system, and inhibition of MDA-7/IL-24 degradation enhances the antitumor activity

R. Ramesh, B. Gopalan, S. Chada, 2008, Cancer Gene Therapy.

Differentiation of Human Hematopoietic Cells Increases Expression of a Gene Transferred by a Retroviral Vector

P. Newburger, S. Chada, J. Greenberger, 1989, Journal of leukocyte biology.

MDA-7 results in downregulation of AKT concomitant with apoptosis and cell cycle arrest in breast cancer cells

K. Hunt, V. Valero, K. Keyomarsi, 2011, Cancer Gene Therapy.

Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro

W. Salser, S. Chada, R. Gatti, 1986, Molecular and cellular biology.

Combination therapy of Ad-mda7 and trastuzumab increases cell death in Her-2/neu-overexpressing breast cancer cells.

K. Hunt, S. Swisher, S. Chada, 2004, Surgery.

Isolation and chromosomal localization of the human glutathione peroxidase gene.

P. Newburger, M. L. Le Beau, S. Chada, 1990, Genomics.

Bystander activity of Ad-mda7: human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism.

R. Ramesh, A. Mhashilkar, S. Chada, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Layered Amplification of Gene Expression with a DNA Gene Delivery System

T. Banks, T. Dubensky, S. Chada, 1995, Annals of the New York Academy of Sciences.

Cytokine induction of interleukin‐24 in human peripheral blood mononuclear cells

S. Chada, E. Grimm, N. Poindexter, 2005, Journal of leukocyte biology.

Intratumoral injection of INGN 241, a nonreplicating adenovector expressing the melanoma-differentiation associated gene-7 (mda-7/IL24): biologic outcome in advanced cancer patients.

Yuan Zhang, R. Ramesh, N. Senzer, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

mRNA species regulated during the differentiation of HL-60 cells to macrophages and neutrophils.

W. Salser, S. Chada, R. Gatti, 1987, Developmental biology.

Loss of MDA-7 expression with progression of melanoma.

L. Broemeling, S. Chada, V. Prieto, 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Intra-articular IL-4 gene therapy in arthritis: anti-inflammatory effect and enhanced Th2activity

G. Firestein, Y. Shi, S. Chada, 1999, Gene Therapy.

The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells.

Jack A Roth, J. Roth, R. Ramesh, 2002, Molecular cancer therapeutics.

Modulation of Gene Expression in Human Central Nervous System Tumors under Methionine Deprivation-induced Stress

S. Chada, Mansoor M Ahmed, D. Kokkinakis, 2004, Cancer Research.

Adenovirus-mediated wild-typep53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer

Michael Bouvet, Richard J. Bold, David J. McConkey, 1998, Annals of Surgical Oncology.

Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments].

J. Roth, R. Bold, D. McConkey, 1998, Annals of surgical oncology.

Induction of HIV-specific CTL and antibody responses in mice using retroviral vector-transduced cells.

S. Chada, D. Jolly, C. Anderson, 1991, AIDS research and human retroviruses.

Chronic granulomatous disease and glutathione peroxidase deficiency, revisited.

P. Newburger, S. Malawista, M. Dinauer, 1994, Blood.

Direct retrovirus-mediated gene transfer to the synovium of the rabbit knee: implications for arthritis gene therapy

E. Lechman, S. Chada, P. Robbins, 1997, Gene Therapy.

CTL cross reactivity between HIV strains.

S. Chada, D. Jolly, M. Bodner, 1992, AIDS research and human retroviruses.

Dendritic cells transduced with full-length wild-type p53 generate antitumor cytotoxic T lymphocytes from peripheral blood of cancer patients.

D. Carbone, A. Virmani, S. Chada, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Mitotic Arrest, Apoptosis, and Sensitization to Chemotherapy of Melanomas by Methionine Deprivation Stress

J. Kirkwood, S. Chada, D. Bocangel, 2006, Molecular Cancer Research.

Apoptosis Modulators: p53 Targeting

J. Roth, S. Chada, D. Bocangel, 2007 .

REGULATION OF HUMAN GLUTATHIONE PEROXIDASE GENE EXPRESSION BY SELENIUM

P. Newburger, S. Chada, 1989 .

in vitro myeloid and monocytic differentiation Regulation of the human cellular glutathione peroxidase gene during

P. Newburger, S. Chada, C. Whitney, 2011 .

Regulation of the human cellular glutathione peroxidase gene during in vitro myeloid and monocytic differentiation.

P. Newburger, S. Chada, C. Whitney, 1994, Blood.

Construction and immunogenicity of Salmonella typhimurium vaccine vectors that express HIV-1 gp120.

S. Chada, R. Tuskan, G. Lewis, 1995, Vaccine.

Cancer Therapy : Clinical Biomarkers Predict p 53 Gene Therapy Efficacy in Recurrent Squamous Cell Carcinoma of the Head and Neck

J. Roth, J. Baselga, M. Olivier, 2009 .

Vitamin E succinate in combination with mda-7 results in enhanced human ovarian tumor cell killing through modulation of extrinsic and intrinsic apoptotic pathways.

R. Ramesh, B. Gopalan, S. Chada, 2007, Cancer letters.

p 53 therapy in a patient with Li-Fraumeni syndrome

R. Eeles, M. Gore, N. Senzer, 2007 .

p53 therapy in a patient with Li-Fraumeni syndrome

R. Eeles, M. Gore, N. Senzer, 2007, Molecular Cancer Therapeutics.

Meta-Analysis of Adenoviral p53 Gene Therapy Clinical Trials in Recurrent Head and Neck Squamous Cell Carcinoma

J. Nemunaitis, S. Chada, D. Wiederhold, 2021, medRxiv.

Genomic structure, chromosomal localization and expression profile of a novel melanoma differentiation associated (mda-7) gene with cancer specific growth suppressing and apoptosis inducing properties

S. Pestka, N. Goldstein, P. Fisher, 2001, Oncogene.

Ectopic production of MDA-7/IL-24 inhibits invasion and migration of human lung cancer cells.

R. Ramesh, Yuji Saito, B. Gopalan, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Melanoma Differentiation-Associated Gene-7/IL-24 Gene Enhances NF-κB Activation and Suppresses Apoptosis Induced by TNF

B. Aggarwal, A. Mhashilkar, S. Chada, 2004, The Journal of Immunology.

The Protein Product of the Tumor Suppressor Gene, Melanoma Differentiation-Associated Gene 7, Exhibits Immunostimulatory Activity and Is Designated IL-241

M. Retter, A. Mhashilkar, S. Chada, 2002, The Journal of Immunology.

Combination of p53 Cancer Vaccine with Chemotherapy in Patients with Extensive Stage Small Cell Lung Cancer

G. Bepler, W. Janssen, S. Chada, 2006, Clinical Cancer Research.

mda-7 In combination with bevacizumab treatment produces a synergistic and complete inhibitory effect on lung tumor xenograft.

S. Inoue, R. Ramesh, S. Chada, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

MDA-7/IL-24 is a unique cytokine--tumor suppressor in the IL-10 family.

Jack A Roth, Suhendan Ekmekcioglu, Elizabeth A Grimm, 2004, International immunopharmacology.

The tumor suppressor activity of MDA-7/IL-24 is mediated by intracellular protein expression in NSCLC cells.

Stephen G Swisher, Elizabeth A Grimm, S. Swisher, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Tumor suppressor MDA-7/IL-24 selectively inhibits vascular smooth muscle cell growth and migration.

A. Mhashilkar, S. Chada, Jiyuan Chen, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

mda-7/IL-24, A Novel Cancer Selective Apoptosis Inducing Cytokine Gene: From the Laboratory into the Clinic

Paul Dent, Elizabeth A Grimm, P. Fisher, 2003, Cancer biology & therapy.

Killing of human melanoma cells induced by activation of class I interferon-regulated signaling pathways via MDA-7/IL-24.

S. Chada, E. Grimm, S. Ekmekcioglu, 2008, Cytokine.

Interleukin-24 overcomes temozolomide resistance and enhances cell death by down-regulation of O6-methylguanine-DNA methyltransferase in human melanoma cells

R. Ramesh, S. Chada, D. Bocangel, 2008, Molecular Cancer Therapeutics.

mda-7/IL-24, novel anticancer cytokine: focus on bystander antitumor, radiosensitization and antiangiogenic properties and overview of the phase I clinical experience (Review).

S. Inoue, P. Fisher, R. Ramesh, 2007, International journal of oncology.

Synergistic tumoricidal effect between celecoxib and adenoviral-mediated delivery of mda-7 in human breast cancer cells.

K. Hunt, S. Swisher, A. Lucci, 2005, Surgery.

mda-7/IL24 kills pancreatic cancer cells by inhibition of the Wnt/PI3K signaling pathways: identification of IL-20 receptor-mediated bystander activity against pancreatic cancer.

R. Ramesh, A. Mhashilkar, S. Chada, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Adenovirus-mediated mda-7 (IL24) gene therapy suppresses angiogenesis and sensitizes NSCLC xenograft tumors to radiation.

R. Ramesh, S. Chada, R. Meyn, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells.

K. Hunt, J. Roth, R. Ramesh, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Down‐regulated melanoma differentiation associated gene (mda‐7) expression in human melanomas

A. Sahin, A. Mhashilkar, S. Chada, 2001, International journal of cancer.

Heat-shock protein 90 inhibitors synergistically enhance melanoma differentiation-associated gene-7-mediated cell killing of human pancreatic carcinoma

Y. Jiang, M. Shingyoji, S. Chada, 2013, Cancer Gene Therapy.

Structural Mapping of Post-translational Modifications in Human Interleukin-24

R. Ramesh, M. Craxton, S. Chada, 2009, The Journal of Biological Chemistry.

Combinatorial synergy induced by adenoviral-mediated mda-7 and Herceptin in Her-2+ breast cancer cells

K. Hunt, R. Ramesh, A. Mhashilkar, 2006, Cancer Gene Therapy.

Adenoviral melanoma differentiation-associated gene 7 induces apoptosis in lung cancer cells through mitochondrial permeability transition-independent cytochrome c release.

K. Hunt, J. Roth, S. Swisher, 2003, The Journal of thoracic and cardiovascular surgery.

Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR).

Stephen G Swisher, Jack A Roth, Kelly K Hunt, 2002, Cancer research.

Melanoma differentiation-associated gene-7 (mda-7)/interleukin (IL)-24 induces anticancer immunity in a syngeneic murine model

R. Ramesh, S. Chada, N. Tsuda, 2006, Cancer Gene Therapy.

Double-Stranded RNA-dependent Protein Kinase ( PKR ) of Lung Cancer Cells via Up-Regulation of the ) Induces Apoptosis mda 7 Differentiation-associated Gene 7 ( Adenoviral Transfer of the Melanoma

K. Hunt, J. Roth, S. Swisher, 2002 .

Cancer targeting using tumor suppressor genes.

J. Roth, R. Ramesh, S. Chada, 2008, Frontiers in bioscience : a journal and virtual library.

Selective induction of cell cycle arrest and apoptosis in human prostate cancer cells through adenoviral transfer of the melanoma differentiation-associated −7 (mda-7)/interleukin-24 (IL-24) gene

S. Inoue, J. Roth, R. Ramesh, 2005, Cancer Gene Therapy.

IL‐24 is expressed during wound repair and inhibits TGFα‐induced migration and proliferation of keratinocytes

A. Caudle, G. Powis, S. Chada, 2009, Experimental dermatology.

Development of vaccines against self-antigens: the p53 paradigm.

J. Roth, A. Mhashilkar, S. Chada, 2003, Current opinion in drug discovery & development.

955. Bystander Activity of Ad-mda7: MDA-7 Protein Kills Melanoma Cells Via a Receptor-Dependent but STAT3-Independent Mechanism

R. Ramesh, A. Mhashilkar, S. Chada, 2004 .

Phosphorylation of interleukin (IL)-24 is required for mediating its anti-cancer activity

R. Ramesh, S. Chada, C. Branch, 2015, Oncotarget.

Local and systemic inhibition of lung tumor growth after nanoparticle-mediated mda-7/IL-24 gene delivery.

J. Roth, R. Ramesh, Yuji Saito, 2004, DNA and cell biology.

Adenovirus-mediated interleukin (IL)-24 immunotherapy for cancer.

J. Roth, R. Ramesh, S. Chada, 2010, Methods in molecular biology.

Development of Ad-mda7/IL-24-resistant lung cancer cell lines

K. Hunt, J. Roth, S. Swisher, 2008, Cancer biology & therapy.

and Is Designated IL-24 Gene 7, Exhibits Immunostimulatory Activity Gene, Melanoma Differentiation-Associated The Protein Product of the Tumor Suppressor

M. Retter, A. Mhashilkar, S. Chada, 2002 .

Expression of a murine homolog of apoptosis-inducing human IL-24/MDA-7 in murine tumors fails to induce apoptosis or produce anti-tumor effects.

S. Chada, M. Tagawa, K. Tatsumi, 2012, Cellular immunology.

Monoclonal antibody that distinguishes between a phosphorylated, beta 2-microglobulin-associated, and a free, nonphosphorylated, chain of MHC class I.

S. Chada, R. Dutton, G. Thor, 1993, Journal of immunology.

MDA-7/IL-24-based cancer gene therapy: translation from the laboratory to the clinic.

S. Inoue, R. Ramesh, M. Andreeff, 2006, Current gene therapy.

Evidence for localization of biologically active recombinant retroviral vector to lymph nodes in mice injected intramuscularly.

S. Chada, S. Mento, W. Edwards, 1996, Gene therapy.

PI3 kinase blockade by Ad-PTEN inhibits invasion and induces apoptosis in RGP and metastatic melanoma cells.

J. Roth, R. Ramesh, Yuji Saito, 2002, Molecular medicine.

Recombinant retroviral vector delivered intramuscularly localizes to the site of injection in mice.

S. Chada, S. Mento, D. Jolly, 1994, Human gene therapy.

Post-transcriptional regulation of glutathione peroxidase gene expression by selenium in the HL-60 human myeloid cell line.

P. Newburger, S. Chada, C. Whitney, 1989, Blood.