Dong Yu

发表

Experimental therapy of human prostate cancer by inhibiting MDM2 expression with novel mixed‐backbone antisense oligonucleotides: In vitro and in vivo activities and mechanisms

Dong Yu, Sudhir Agrawal, Hui Wang, 2003, The Prostate.

Antisense Anti-MDM 2 Oligonucleotides As a Novel Therapeutic Approach to Human Breast Cancer : In Vitro and in Vivo Activities and Mechanisms 1

Hui Wang, Dong Yu, S. Agrawal, 2001 .

Design of synthetic oligoribonucleotide-based agonists of Toll-like receptor 3 and their immune response profiles in vitro and in vivo.

Dong Yu, S. Agrawal, N. La Monica, 2013, Organic & biomolecular chemistry.

Immunostimulatory properties of phosphorothioate CpG DNA containing both 3'-5'- and 2'-5'-internucleotide linkages.

Dong Yu, S. Agrawal, Qiuyan Zhao, 2002, Nucleic acids research.

Potent CpG oligonucleotides containing phosphodiester linkages: in vitro and in vivo immunostimulatory properties.

Hui Wang, Dong Yu, S. Agrawal, 2002, Biochemical and biophysical research communications.

Anti-Tumor Efficacy of a Novel Antisense Anti-MDM2 Mixed-Backbone Oligonucleotide in Human Colon Cancer Models: p53-Dependent and p53-Independent Mechanisms

Hui Wang, Dong Yu, S. Agrawal, 2002, Molecular medicine.

GEM 231, a second-generation antisense agent complementary to protein kinase A RIalpha subunit, potentiates antitumor activity of irinotecan in human colon, pancreas, prostate and lung cancer xenografts.

Dong Yu, S. Agrawal, B. Hollister, 2002, International journal of oncology.

Antisense oligonucleotide targeted to RIalpha subunit of cAMP-dependent protein kinase (GEM231) enhances therapeutic effectiveness of cancer chemotherapeutic agent irinotecan in nude mice bearing human cancer xenografts: in vivo synergistic activity, pharmacokinetics and host toxicity.

Hui Wang, Dong Yu, S. Agrawal, 2002, International journal of oncology.

Acyloxyaryl prodrugs of oligonucleoside phosphorothioates

N. Ho, Dong Yu, S. Agrawal, 1996 .

Oligodeoxyribonucleotide-based antagonists for Toll-like receptors 7 and 9.

Dong Yu, S. Agrawal, E. Kandimalla, 2009, Journal of medicinal chemistry.

Modifications incorporated in CpG motifs of oligodeoxynucleotides lead to antagonist activity of toll-like receptors 7 and 9.

Dong Yu, S. Agrawal, E. Kandimalla, 2009, Journal of medicinal chemistry.

Conjugation of ligands at the 5'-end of CpG DNA affects immunostimulatory activity.

Dong Yu, S. Agrawal, E. Kandimalla, 2002, Bioconjugate chemistry.

Antitumor Activity and Immune Response Induction of a Dual Agonist of Toll-Like Receptors 7 and 8

Dong Yu, S. Agrawal, T. Lan, 2010, Molecular Cancer Therapeutics.

Oral administration of second-generation immunomodulatory oligonucleotides induces mucosal Th1 immune responses and adjuvant activity.

Dong Yu, S. Agrawal, E. Kandimalla, 2005, Vaccine.

Oral administration of a synthetic agonist of Toll-like receptor 9 potently modulates peanut-induced allergy in mice.

Dong Yu, S. Agrawal, E. Kandimalla, 2007, The Journal of allergy and clinical immunology.

Synthesis and immunological activities of novel agonists of toll-like receptor 9.

M. Struthers, Hao Wang, Dong Yu, 2010, Cellular immunology.

An In Situ Autologous Tumor Vaccination with Combined Radiation Therapy and TLR9 Agonist Therapy

Dong Yu, S. Agrawal, C. Guha, 2012, PloS one.

A Toll-like receptor 7, 8, and 9 antagonist inhibits Th1 and Th17 responses and inflammasome activation in a model of IL-23-induced psoriasis.

Dong Yu, S. Agrawal, N. La Monica, 2013, The Journal of investigative dermatology.

Self-stabilized CpG DNAs optimally activate human B cells and plasmacytoid dendritic cells.

Dong Yu, S. Agrawal, R. Pandey, 2003, Biochemical and biophysical research communications.

Effect of synthetic agonists of toll-like receptor 9 on canine lymphocyte proliferation and cytokine production in vitro.

Dong Yu, J. Peel, A. Zurbriggen, 2008, Veterinary immunology and immunopathology.

Improved Procedure for the Reduction of N - 1 Content in Synthetic Oligonucleotides

Dong Yu, S. Agrawal, Zhiwei Jiang, 1995 .

A NOVEL NUCLEOSIDE PHOSPHORAMIDITE SYNTHON DERIVED FROM 1R,2S-EPHEDRINE

N. Ho, Dong Yu, S. Agrawal, 1995 .

Stereospecific bio-reversibility of dinucleoside S-alkyl phosphorothiolates to dinucleoside phosphorothioates

Dong Yu, S. Agrawal, R. Iyer, 1994 .

Synthetic oligoribonucleotides-containing secondary structures act as agonists of Toll-like receptors 7 and 8.

Dong Yu, S. Agrawal, T. Lan, 2009, Biochemical and biophysical research communications.

Secondary structures in CpG oligonucleotides affect immunostimulatory activity.

Dong Yu, S. Agrawal, R. Pandey, 2003, Biochemical and biophysical research communications.

Requirement of nucleobase proximal to CpG dinucleotide for immunostimulatory activity of synthetic CpG DNA.

Dong Yu, S. Agrawal, Qiuyan Zhao, 2003, Bioorganic & medicinal chemistry.

CpG penta- and hexadeoxyribonucleotides as potent immunomodulatory agents.

Hui Wang, Dong Yu, S. Agrawal, 2003, Biochemical and biophysical research communications.

Radiosensitization by Antisense Anti-MDM2 Mixed-Backbone Oligonucleotide in in Vitro and in Vivo Human Cancer Models

Hui Wang, Dong Yu, S. Agrawal, 2004, Clinical Cancer Research.

Solid-phase stereoselective synthesis of oligonucleoside phosphorothioates: The nucleoside bicyclic oxazaphospholidines as novel synthons

Dong Yu, S. Agrawal, R. Iyer, 1998 .

Oligonucleoside phosphoramidates from N-pent-4-enoyl nucleoside H-phosphonates

Dong Yu, S. Agrawal, R. Iyer, 1996 .

N-pent-4-enoyl nucleosides: Application in the synthesis of support-bound and free oligonucleotide analogs by the H-phosphonate approach

N. Ho, Dong Yu, S. Agrawal, 1996 .

N-pent-4-enoyl (PNT) group as a universal nucleobase protector: Applications in the rapid and facile synthesis of oligonucleotides, analogs, and conjugates

J. Xie, N. Ho, Dong Yu, 1997 .

Synthesis, biophysical properties, and stability studies of mixed backbone oligonucleotides containing segments of methylphosphotriester internucleotidic linkages

Dong Yu, S. Agrawal, Zhiwei Jiang, 1996 .

Modulation of ovalbumin-induced Th2 responses by second-generation immunomodulatory oligonucleotides in mice.

Dong Yu, S. Agrawal, E. Kandimalla, 2004, International immunopharmacology.

Novel immunomodulatory oligonucleotides prevent development of allergic airway inflammation and airway hyperresponsiveness in asthma.

D. Agrawal, Dong Yu, S. Agrawal, 2004, International immunopharmacology.

Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles.

Hui Wang, Dong Yu, S. Agrawal, 2003, Nucleic acids research.

'Immunomers'--novel 3'-3'-linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents.

Dong Yu, S. Agrawal, J. Tang, 2002, Nucleic acids research.

Bioreversible oligonucleotide conjugates by site-specific derivatization

N. Ho, Dong Yu, S. Agrawal, 1997 .

Synthesis of Iodoalkylacylates and Their Use in the preparation of S-Alkyl Phosphorothiolates

N. Ho, Dong Yu, S. Agrawal, 1995 .

Novel oligonucleotides containing two 3'-ends complementary to target mRNA show optimal gene-silencing activity.

Dong Yu, S. Agrawal, N. La Monica, 2011, Journal of medicinal chemistry.

Design, synthesis, and immunostimulatory properties of CpG DNAs containing alkyl-linker substitutions: role of nucleosides in the flanking sequences.

Dong Yu, S. Agrawal, Qiuyan Zhao, 2002, Journal of medicinal chemistry.

Towards optimal design of second-generation immunomodulatory oligonucleotides.

Dong Yu, S. Agrawal, E. Kandimalla, 2002, Current opinion in molecular therapeutics.

Diethoxy N, N-diisopropyl phosphoramidite as an improved capping reagent in the synthesis of oligonucleotides using phosphoramidite chemistry

Dong Yu, S. Agrawal, R. Iyer, 1994 .

Synthesis, Biophysical Properties, and Stability Studies of Mixed Backbone Oligonucleotides Containing Novel Non-Ionic Linkages

N. Ho, Dong Yu, S. Agrawal, 1997 .

The use of gaseous ammonia for the deprotection and cleavage steps during the solid-phase synthesis of oligonucleotides, and analogs

J. Xie, Dong Yu, S. Agrawal, 1997 .

TLR9 Agonist Protects Mice from Radiation-Induced Gastrointestinal Syndrome

Dong Yu, S. Agrawal, C. Guha, 2012, PloS one.

Oligodeoxynucleotides containing synthetic immunostimulatory motifs augment potent Th1 immune responses to HBsAg in mice.

Dong Yu, S. Agrawal, E. Kandimalla, 2005, International immunopharmacology.

Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9

Dong Yu, S. Agrawal, N. La Monica, 2013, Nucleic acids research.

Synthesis, purification, and characterization of immune-modulatory oligodeoxynucleotides that act as agonists of Toll-like receptor 9.

Dong Yu, E. Kandimalla, M. Putta, 2011, Methods in molecular biology.

Impact of Secondary Structure of Toll-Like Receptor 9 Agonists on Interferon Alpha Induction

Dong Yu, S. Agrawal, E. Kandimalla, 2008, Antimicrobial Agents and Chemotherapy.

Immunomodulatory oligonucleotides containing a cytosine-phosphate-2'-deoxy-7-deazaguanosine motif as potent toll-like receptor 9 agonists.

Dong Yu, S. Agrawal, E. Kandimalla, 2005, Proceedings of the National Academy of Sciences of the United States of America.

A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif

Dong Yu, S. Agrawal, E. Lien, 2003, Proceedings of the National Academy of Sciences of the United States of America.

An efficient synthesis of radioisotopically labeled oligonucleotides through direct solid-phase 5′-phosphitylation

Dong Yu, S. Agrawal, Zhiwei Jiang, 1995 .

O- and S-Methyl Phosphotriester Oligonucleotides: Facile Synthesis Using N-Pent-4-enoyl Nucleoside Phosphoramidites

N. Ho, Dong Yu, S. Agrawal, 1995 .

Improved Procedure for the Detritylation of DMT-Oligonucleotides: Use of Dowex®

Dong Yu, S. Agrawal, Zhiwei Jiang, 1995 .

Prodrugs of Oligonucleotides: The Acyloxyalkyl Esters of Oligodeoxyribonucleoside Phosphorothioates

Dong Yu, S. Agrawal, R. Iyer, 1995 .

Mixed-Backbone Oligonucleotides Containing Segments of Deoxynucleosides Phosphorothioate and 2'-O-Methylribonucleosides Methylphosphonate: Synthesis and Properties

Dong Yu, S. Agrawal, M. Guo, 1999 .

Synthesis of Iodoalkylacylates and Their Use in the Preparation of S‐ Alkyl Phosphorothiolates.

N. Ho, Dong Yu, S. Agrawal, 1995 .

A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice

Dong Yu, S. Agrawal, N. La Monica, 2013, Autoimmunity.

Site-specific synthesis of [3H]oligonucleotides in high specific activity through direct solid-phase redox chemistry

Dong Yu, S. Agrawal, R. Iyer, 1995 .

Preclinical Characterization of AEG35156/GEM 640, a Second-Generation Antisense Oligonucleotide Targeting X-Linked Inhibitor of Apoptosis

Hui Wang, Dong Yu, S. Agrawal, 2006, Clinical Cancer Research.

Agonists of Toll-like receptor 9 containing synthetic dinucleotide motifs.

Dong Yu, S. Agrawal, E. Kandimalla, 2007, Journal of Medicinal Chemistry.

Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration.

Hui Wang, Dong Yu, S. Agrawal, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Stabilized immune modulatory RNA compounds as agonists of Toll-like receptors 7 and 8

Dong Yu, S. Agrawal, T. Lan, 2007, Proceedings of the National Academy of Sciences.

IMO-3100, an Antagonist of Toll-Like Receptors 7 and 9, Modulates Gene Expression and Regulatory Networks Induced by Ligands (48.25)

Dong Yu, S. Agrawal, E. Kandimalla, 2009, The Journal of Immunology.

Immunopharmacological and antitumor effects of second-generation immunomodulatory oligonucleotides containing synthetic CpR motifs.

Dong Yu, S. Agrawal, E. Kandimalla, 2004, International journal of oncology.

Nucleoside Oxazaphospholidines as Novel Synthons in Oligonucleotide Synthesis

N. Ho, Dong Yu, S. Agrawal, 1995 .

Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: in vitro and in vivo activities and mechanisms.

Hui Wang, Dong Yu, S. Agrawal, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Antitumor Activity and Immune Response Induction of a Dual Agonist of Toll-Like Receptors 7 and 8

Dong Yu, S. Agrawal, T. Lan, 2010, Molecular Cancer Therapeutics.

In vivo stability, disposition and metabolism of a "hybrid" oligonucleotide phosphorothioate in rats.

R. Diasio, Dong Yu, S. Agrawal, 1995, Biochemical pharmacology.

Effect of chemical modifications of cytosine and guanine in a CpG-motif of oligonucleotides: structure-immunostimulatory activity relationships.

Dong Yu, S. Agrawal, Qiuyan Zhao, 2001, Bioorganic & medicinal chemistry.