S. Agrawal

H. Pillsbury, S. Agrawal, C. Ebert, 2007, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

Immune Modulatory Oligonucleotides in the Prevention and Treatment of OVA-Induced Eustachian Tube Dysfunction in Rats

C. Zdanski, S. Agrawal, C. Ebert, 2007, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

The role of immunomodulatory oligonucleotides in prevention of OVA-induced Eustachian tube dysfunction.

H. Pillsbury, S. Agrawal, C. Ebert, 2006, International journal of pediatric otorhinolaryngology.

Immunomodulatory oligonucleotides as novel therapy for breast cancer: pharmacokinetics, in vitro and in vivo anticancer activity, and potentiation of antibody therapy

Hui Wang, S. Agrawal, Ruiwen Zhang, 2006, Molecular Cancer Therapeutics.

Novel oligodeoxynucleotide agonists of TLR9 containing N3-Me-dC or N1-Me-dG modifications

S. Agrawal, E. Kandimalla, Yukui Li, 2006, Nucleic acids research.

Novel immunomodulatory oligonucleotides prevent development of allergic airway inflammation and airway hyperresponsiveness in asthma.

D. Agrawal, Dong Yu, S. Agrawal, 2004, International immunopharmacology.

Modulation of Toll‐like Receptor 9 Responses through Synthetic Immunostimulatory Motifs of DNA

S. Agrawal, E. Kandimalla, EKAMBAR R. KANDIMALLA, 2003, Annals of the New York Academy of Sciences.

Divergent synthetic nucleotide motif recognition pattern: design and development of potent immunomodulatory oligodeoxyribonucleotide agents with distinct cytokine induction profiles.

Hui Wang, Dong Yu, S. Agrawal, 2003, Nucleic acids research.

'Immunomers'--novel 3'-3'-linked CpG oligodeoxyribonucleotides as potent immunomodulatory agents.

Dong Yu, S. Agrawal, J. Tang, 2002, Nucleic acids research.

Bioreversible oligonucleotide conjugates by site-specific derivatization

N. Ho, Dong Yu, S. Agrawal, 1997 .

Synthesis, purification, and characterization of 2,4,6-trinitrophenyl-UDP-galactose: a fluorescent substrate for galactosyltransferase.

D. E. Wolf, R. Cardullo, S. Agrawal, 1990, Analytical biochemistry.

Sequence identity of the n-1 product of a synthetic oligonucleotide.

S. Agrawal, J. Temsamani, S Agrawal, 1995, Nucleic acids research.

Advances in antisense efficacy and delivery.

S. Agrawal, S. Akhtar, 1995, Trends in biotechnology.

Pharmacokinetics and tissue disposition of a chimeric oligodeoxynucleoside phosphorothioate in rats after intravenous administration.

S. Agrawal, R. Zhang, R. Iyer, 1996, The Journal of pharmacology and experimental therapeutics.

Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey.

S. Agrawal, P. Schechter, W. Hobson, 1994, Antisense research and development.

Functionalization of oligonucleotides with amino groups and attachment of amino specific reporter groups.

S. Agrawal, 1994, Methods in molecular biology.

Synthesis of Iodoalkylacylates and Their Use in the preparation of S-Alkyl Phosphorothiolates

N. Ho, Dong Yu, S. Agrawal, 1995 .

Introduction and History of the Chemistry of Nucleic Acids Therapeutics

S. Agrawal, M. Gait, Michael J. Gait, 2022, Methods in molecular biology.

Novel oligonucleotides containing two 3'-ends complementary to target mRNA show optimal gene-silencing activity.

Dong Yu, S. Agrawal, N. La Monica, 2011, Journal of medicinal chemistry.

Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration.

S. Agrawal, H. Wang, D. Yu, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Pharmacokinetics and metabolism of an oligodeoxynucleotide phosphorothioate (GEM91) in cynomolgus monkeys following intravenous infusion.

S. Agrawal, Z. Jiang, A. Roskey, 1998, Antisense & nucleic acid drug development.

Pharmacokinetics and bioavailability of antisense oligonucleotides following oral and colorectal administrations in experimental animals

S. Agrawal, R. Zhang, 1998 .

Effect of aspirin on protein binding and tissue disposition of oligonucleotide phosphorothioate in rats.

S. Agrawal, R. Zhang, E. Kandimalla, 1998, Journal of drug targeting (Print).

Pharmacokinetics of oligonucleotides.

S. Agrawal, R. Zhang, 2007, Ciba Foundation symposium.

Toxicologic effects of an oligodeoxynucleotide phosphorothioate and its analogs following intravenous administration in rats.

S. Agrawal, Z. Jiang, D. Serota, 1997, Antisense & nucleic acid drug development.

Perspectives in antisense therapeutics.

S. Agrawal, R. Iyer, 1997, Pharmacology & therapeutics.

In vivo pharmacokinetics of phosphorothioate oligonucleotides containing contiguous guanosines.

S. Agrawal, R. Zhang, Q. Cai, 1997, Antisense and Nucleic Acid Drug Development.

In vivo metabolic profile of a phosphorothioate oligodeoxyribonucleotide.

S. Agrawal, C. Chaix, J. Temsamani, 1997, Antisense & nucleic acid drug development.

Mixed backbone antisense oligonucleotides: design, biochemical and biological properties of oligonucleotides containing 2'-5'-ribo- and 3'-5'-deoxyribonucleotide segments.

V. Sasisekharan, S. Agrawal, R. Byrn, 1997, Nucleic acids research.

Agonists of Toll-Like Receptor 9

S. Agrawal, E. Kandimalla, 2005 .

Immunostimulatory activity of CpG containing phosphorothioate oligodeoxynucleotide is modulated by modification of a single deoxynucleoside.

S. Agrawal, D. Yu, Q. Zhao, 2000, Bioorganic & medicinal chemistry letters.

Site of chemical modifications in CpG containing phosphorothioate oligodeoxynucleotide modulates its immunostimulatory activity.

S. Agrawal, D. Yu, Q. Zhao, 1999, Bioorganic & medicinal chemistry letters.

Synthesis of [35S]3H-1,2-benzodithiole-3-one-1,1-dioxide: Application in the Preparation of site-specifically 35S-labeled oligonucleotides

S. Agrawal, R. Iyer, W. Tan, 1994 .

Single strand targeted triplex formation: parallel-stranded DNA hairpin duplexes for targeting pyrimidine strands

V. Sasisekharan, S. Agrawal, G. Venkataraman, 1995 .

Antisense oligonucleotides: gene regulation and chemotherapy of AIDS

S. Agrawal, P. Sarin, 1991 .

Synthesis of di-, tri-, and tetrameric building blocks with novel carbamate internucleoside linkages and their incorporation into oligonucleotides

S. Agrawal, J. Temsamani, I. Habuš, 1994 .

Impact of Site-Specific Nucleobase Deletions on the Arthritogenicity of DNA

S. Agrawal, A. Tarkowski, E. Kandimalla, 2004, Inflammation.

Pharmacokinetics, biodistribution, and stability of capped oligodeoxynucleotide phosphorothioates in mice.

S. Agrawal, J. Temsamani, J. Tang, 1993, Antisense research and development.

Single strand targeted triplex formation: targeting purine-pyrimidine mixed sequences using abasic linkers.

V. Sasisekharan, S. Agrawal, G. Venkataraman, 1995, Nucleic acids research.

Pharmacokinetics of an anti—human immunodeficiency virus antisense oligodeoxynucleotide phosphorothioate (GEM 91) in HIV‐infected subjects

R. Diasio, M. Saag, S. Agrawal, 1995, Clinical pharmacology and therapeutics.

Efficient synthesis of oligoribonucleotide and its phosphorothioate analogue using H-phosphonate approach

S. Agrawal, J. Tang, 1990 .

Phosphoramidate, Phosphorothioate, and Methylphosphonate Analogs of Oligodeoxynucleotide : Inhibitors of Replication of Human Immunodeficiency Virus

P. Zamecnik, S. Agrawal, M. Civeira, 1989 .

Antisense oligonucleotides: towards clinical trials.

S. Agrawal, Sudhir Agrawal, 1996, Trends in biotechnology.

Analytical study of phosphorothioate analogues of oligodeoxynucleotides using high-performance liquid chromatography.

S. Agrawal, J. Tang, D. M. Brown, 1990, Journal of chromatography.

Protocols for Oligonucleotide Conjugates

S. Agrawal, 1993 .

Design, synthesis, and immunostimulatory properties of CpG DNAs containing alkyl-linker substitutions: role of nucleosides in the flanking sequences.

Dong Yu, S. Agrawal, Qiuyan Zhao, 2002, Journal of medicinal chemistry.

Towards optimal design of second-generation immunomodulatory oligonucleotides.

Dong Yu, S. Agrawal, E. Kandimalla, 2002, Current opinion in molecular therapeutics.

Antisense and/or immunostimulatory oligonucleotide therapeutics.

S. Agrawal, E. Kandimalla, 2001, Current cancer drug targets.

Capped Oligodeoxynucleotide Phosphorothioates.

S. Agrawal, J. Temsamani, J.‐Y. Tang, 1992, Annals of the New York Academy of Sciences.

Biodistribution and metabolism of a mixed backbone oligonucleotide (GEM 231) following single and multiple dose administration in mice.

S. Agrawal, M. Rusckowski, T. Qu, 2000, Antisense & nucleic acid drug development.

Cellular uptake of oligodeoxynucleotide phosphorothioates and their analogs.

S. Agrawal, J. Temsamani, J. Tang, 1994, Antisense research and development.

Synthesis of oligodeoxynucleoside methylphosphonothioates

S. Agrawal, A. Padmapriya, 1993 .

Pharmacokinetics, biodistribution, and stability of oligodeoxynucleotide phosphorothioates in mice.

S. Agrawal, J. Temsamani, J. Tang, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Cell binding, uptake and cytosolic partition of HIV anti-gag phosphodiester oligonucleotides 3'-linked to cholesterol derivatives in macrophages.

S. Agrawal, J. Tenu, T. Ledoan, 1999, Bioorganic & medicinal chemistry.

Mixed backbone oligonucleotides containing internucleotidic primary phosphoramidate linkages

S. Agrawal, R. Iyer, T. Devlin, 1996 .

Diethoxy N, N-diisopropyl phosphoramidite as an improved capping reagent in the synthesis of oligonucleotides using phosphoramidite chemistry

Dong Yu, S. Agrawal, R. Iyer, 1994 .

Synthesis and Anti‐HIV Activity of Oligoribonucleotides and Their Phosphorothioate Analogs

P. Zamecnik, S. Agrawal, J. Tang, 1992, Annals of the New York Academy of Sciences.

Ion Exchange HPLC Analysis of Oligoribonucleotides and Chimeric Oligoribo‐oligodeoxyribonucleotides a

S. Agrawal, K. Misiura, V. Metelev, 1992, Annals of the New York Academy of Sciences.

Incompatibility of acid-labile 2′ and 5′ protecting groups for solid-phase synthesis of oligoribonucleotides

S. Agrawal, C. Christodoulou, M. Gait, 1986 .

Synthesis, Biophysical Properties, and Stability Studies of Mixed Backbone Oligonucleotides Containing Novel Non-Ionic Linkages

N. Ho, Dong Yu, S. Agrawal, 1997 .

The use of gaseous ammonia for the deprotection and cleavage steps during the solid-phase synthesis of oligonucleotides, and analogs

J. Xie, Dong Yu, S. Agrawal, 1997 .

3′-3′-linked oligonucleotides: Synthesis and stability studies

S. Agrawal, C. Chaix, R. Iyer, 1996 .

A mild and efficient solid-support synthesis of novel oligonucleotide conjugates.

S. Agrawal, R. Iyer, L. X. Shen, 1998, Bioconjugate chemistry.

Ion-exchange high-performance liquid chromatography analysis of oligodeoxyribonucleotide phosphorothioates.

S. Agrawal, V. Metelev, 1992, Analytical biochemistry.

Impact of mixed-backbone oligonucleotides on target binding affinity and target cleaving specificity and selectivity by Escherichia coli RNase H.

S. Agrawal, L. X. Shen, E. Kandimalla, 1998, Bioorganic & medicinal chemistry.

Uptake, intracellular distribution, and stability of oligodeoxynucleotide phosphorothioate by Schistosoma mansoni.

R. M. Coleman, K. Marx, S. Agrawal, 1995, Antisense research and development.

Protocols for oligonucleotide conjugates : synthesis and analytical techniques

S. Agrawal, 1994 .

Mixed-backbone oligonucleotides as second-generation antisense agents with reduced phosphorothioate-related side effects.

S. Agrawal, W. Zhou, Wenqiang Zhou, 1998, Bioorganic & medicinal chemistry letters.

TLR9 Agonist Protects Mice from Radiation-Induced Gastrointestinal Syndrome

Dong Yu, S. Agrawal, C. Guha, 2012, PloS one.

Single-stranded DNA and RNA targeted triplex-formation: UV, CD and molecular modeling studies of foldback triplexes containing different RNA, 2'-OMe-RNA and DNA strand combinations.

V. Sasisekharan, S. Agrawal, G. Venkataraman, 1997, Journal of biomolecular structure & dynamics.

Novel Toll-Like Receptor 9 Agonist Induces Epidermal Growth Factor Receptor (EGFR) Inhibition and Synergistic Antitumor Activity with EGFR Inhibitors

A. Leonardi, F. D'armiento, G. Tortora, 2006, Clinical Cancer Research.

Oligodeoxynucleotides containing synthetic immunostimulatory motifs augment potent Th1 immune responses to HBsAg in mice.

Dong Yu, S. Agrawal, E. Kandimalla, 2005, International immunopharmacology.

Chemistry of CpG DNA

S. Agrawal, Ekambar R. Kandimalla, Ekambar R. Kandimalla, 2003, Current protocols in nucleic acid chemistry.

Pseudo-cyclic oligonucleotides: in vitro and in vivo properties.

S. Agrawal, L. X. Shen, E. Kandimalla, 1999, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9

Dong Yu, S. Agrawal, N. La Monica, 2013, Nucleic acids research.

Impact of Secondary Structure of Toll-Like Receptor 9 Agonists on Interferon Alpha Induction

Dong Yu, S. Agrawal, E. Kandimalla, 2008, Antimicrobial Agents and Chemotherapy.

Immunomodulatory oligonucleotides containing a cytosine-phosphate-2'-deoxy-7-deazaguanosine motif as potent toll-like receptor 9 agonists.

Dong Yu, S. Agrawal, E. Kandimalla, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Hybridization-based fluorescence assay allows quantitation of single-stranded oligodeoxynucleotides in low nanomolar range.

S. Agrawal, R. Pandey, E. Kandimalla, 2004, Analytical biochemistry.

A dinucleotide motif in oligonucleotides shows potent immunomodulatory activity and overrides species-specific recognition observed with CpG motif

Dong Yu, S. Agrawal, E. Lien, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Antisense therapy targeting MDM2 oncogene in prostate cancer: Effects on proliferation, apoptosis, multiple gene expression, and chemotherapy

Sudhir Agrawal, Hui Wang, Hui Wang, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Chemotherapy and chemosensitization of non–small cell lung cancer with a novel immunomodulatory oligonucleotide targeting Toll-like receptor 9

Hui Wang, S. Agrawal, Ruiwen Zhang, 2006, Molecular Cancer Therapeutics.

MDM2 oncogene as a target for cancer therapy: An antisense approach.

L. Le, S. Agrawal, H. Wang, 1999, International journal of oncology.

A rapid method for quantitation of oligodeoxynucleotide phosphorothioates in biological fluids and tissues.

S. Agrawal, J. Temsamani, M. Kubert, 1993, Analytical biochemistry.

Effect of 2'-O-methyl antisense ORNs on expression of thymidylate synthase in human colon cancer RKO cells.

J. C. Schmitz, E. Chu, S. Agrawal, 2001, Nucleic acids research.

An efficient synthesis of radioisotopically labeled oligonucleotides through direct solid-phase 5′-phosphitylation

Dong Yu, S. Agrawal, Zhiwei Jiang, 1995 .

Enzymatic Synthesis of Stereoregular (All Rp) Oligonucleotide Phosphorothioate and Its Properties

S. Agrawal, Ying Li, J. Tang, 1995 .

Patent strategies in the antisense oligonucleotide based therapeutic approach

Sudhir Agrawal, Anne Craig, Darlene Vanstone, 1997 .

O- and S-Methyl Phosphotriester Oligonucleotides: Facile Synthesis Using N-Pent-4-enoyl Nucleoside Phosphoramidites

N. Ho, Dong Yu, S. Agrawal, 1995 .

Improved Procedure for the Detritylation of DMT-Oligonucleotides: Use of Dowex®

Dong Yu, S. Agrawal, Zhiwei Jiang, 1995 .

Prodrugs of Oligonucleotides: The Acyloxyalkyl Esters of Oligodeoxyribonucleoside Phosphorothioates

Dong Yu, S. Agrawal, R. Iyer, 1995 .

A New 5′-Protecting Group for Use in Solid-Phase Synthesis of Oligoribonucleotides

S. Agrawal, C. Christodoulou, M. Gait, 1987 .

Mixed-Backbone Oligonucleotides Containing Segments of Deoxynucleosides Phosphorothioate and 2'-O-Methylribonucleosides Methylphosphonate: Synthesis and Properties

Dong Yu, S. Agrawal, M. Guo, 1999 .

Synthesis of Iodoalkylacylates and Their Use in the Preparation of S‐ Alkyl Phosphorothiolates.

N. Ho, Dong Yu, S. Agrawal, 1995 .

Novel enzymatic and immunological responses to oligonucleotides.

S. Agrawal, D. Shaw, P. Rustagi, 1995, Toxicology letters.

Sequencing of synthetic oligonucleotides and analogs by homopolymeric tailing.

S. Agrawal, J. Temsamani, M. Kubert, 1995, Nucleic acids research.

A novel antagonist of Toll-like receptors 7, 8 and 9 suppresses lupus disease-associated parameters in NZBW/F1 mice

Dong Yu, S. Agrawal, N. La Monica, 2013, Autoimmunity.

Effect of G-rich sequences on the synthesis, purification, hybridization, cell uptake, and hemolytic activity of oligonucleotides

S. Agrawal, Qiuyan Zhao, J. Temsamani, 1996 .

Repression of human thymidylate synthase mRNA translation by antisense 2'-O-methyl oligoribonucleotides.

J. C. Schmitz, E. Chu, S. Agrawal, 1998, Antisense & nucleic acid drug development.

Site-specific synthesis of [3H]oligonucleotides in high specific activity through direct solid-phase redox chemistry

Dong Yu, S. Agrawal, R. Iyer, 1995 .

'Cyclicons' as hybridization-based fluorescent primer-probes: synthesis, properties and application in real-time PCR.

S. Agrawal, E. Kandimalla, 2000, Bioorganic & medicinal chemistry.

A novel MDM2 anti‐sense oligonucleotide has anti‐tumor activity and potentiates cytotoxic drugs acting by different mechanisms in human colon cancer

G. Tortora, Jiangdong Chen, F. Ciardiello, 2000, International journal of cancer.

Treatment of Mammary Carcinomas in HER-2 Transgenic Mice through Combination of Genetic Vaccine and an Agonist of Toll-Like Receptor 9

G. Ciliberto, S. Agrawal, N. La Monica, 2009, Clinical Cancer Research.

Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation.

S. Agrawal, A. Saluja, M. Steer, 2000, The Journal of clinical investigation.

Combined Targeting of Epidermal Growth Factor Receptor and MDM2 by Gefitinib and Antisense MDM2 Cooperatively Inhibit Hormone-Independent Prostate Cancer

G. Tortora, F. Ciardiello, R. Bianco, 2004, Clinical Cancer Research.

Synergistic activation of p53 by inhibition of MDM2 expression and DNA damage.

Jiandong Chen, Lihong Chen, S. Agrawal, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Toll-like Receptor 9 Agonist IMO Cooperates with Cetuximab in K-Ras Mutant Colorectal and Pancreatic Cancers

A. Bardelli, A. Scarpa, G. Tortora, 2011, Clinical Cancer Research.

Specific removal of the nonsense mutation from the mdx dystrophin mRNA using antisense oligonucleotides

S. Agrawal, R. Kole, S. Wilton, 1999, Neuromuscular Disorders.

Biotinylated antisense methylphosphonate oligodeoxynucleotides. Inhibition of spliceosome assembly and affinity selection of U1 and U2 small nuclear RNPs.

S. Agrawal, T. Pederson, J. Temsamani, 1991, The Journal of biological chemistry.

Detection of nucleic acid hybridization by nonradiative fluorescence resonance energy transfer.

D. E. Wolf, P. Zamecnik, R. Cardullo, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Preclinical Characterization of AEG35156/GEM 640, a Second-Generation Antisense Oligonucleotide Targeting X-Linked Inhibitor of Apoptosis

Hui Wang, Dong Yu, S. Agrawal, 2006, Clinical Cancer Research.

Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

S. Agrawal, C. Lefebvre, J. Durkin, 2004, Oncogene.

Survivin inhibition induces human neural tumor cell death through caspase‐independent and ‐dependent pathways

S. Agrawal, S. Mani, B. Shafit-Zagardo, 2001, Journal of neurochemistry.

Stabilization of the MDM2 Oncoprotein by Mutant p53*

Jiandong Chen, Wenge Lu, Lihong Chen, 2001, The Journal of Biological Chemistry.

Cooperative antitumor effect of mixed backbone oligonucleotides targeting protein kinase A in combination with cytotoxic drugs or biologic agents.

G. Tortora, F. Ciardiello, R. Bianco, 1998, Antisense & nucleic acid drug development.

Cooperative inhibition of renal cancer growth by anti-epidermal growth factor receptor antibody and protein kinase A antisense oligonucleotide.

G. Tortora, F. Ciardiello, R. Bianco, 1998, Journal of the National Cancer Institute.

Synergistic inhibition of human cancer cell growth by cytotoxic drugs and mixed backbone antisense oligonucleotide targeting protein kinase A.

G. Tortora, F. Ciardiello, R. Bianco, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Toll-like receptor 9 agonist IMO cooperates with everolimus in renal cell carcinoma by interfering with tumour growth and angiogenesis

G. Tortora, R. Bianco, S. Agrawal, 2013, British Journal of Cancer.

Cancer Therapy : Preclinical Toll-like Receptor 9 Agonist IMOCooperateswithCetuximab in KRas Mutant Colorectal and Pancreatic Cancers

F. Nicolantonio, A. Bardelli, A. Scarpa, 2011 .

Synergistic growth inhibition and induction of apoptosis by a novel mixed backbone antisense oligonucleotide targeting CRIPTO in combination with C225 anti-EGFR monoclonal antibody and 8-Cl-cAMP in human GEO colon cancer cells.

A. Casamassimi, N. Normanno, G. Tortora, 1999, Oncology reports.

MDM2 Is a Negative Regulator of p21WAF1/CIP1, Independent of p53*

Xinbin Chen, Hui Wang, S. Agrawal, 2004, Journal of Biological Chemistry.

PKA knockdown enhances cell killing in response to radiation and androgen deprivation

R. Stoyanova, S. Agrawal, A. Pollack, 2011, International journal of cancer.

Preparation of functionalized oligonucleoside methylphosphonate suitable for non-radioactive label attachment

S. Agrawal, 1989 .

Agonists of Toll-like receptor 9 containing synthetic dinucleotide motifs.

Dong Yu, S. Agrawal, E. Kandimalla, 2007, Journal of Medicinal Chemistry.

Antitumor activity and pharmacokinetics of a mixed-backbone antisense oligonucleotide targeted to the RIalpha subunit of protein kinase A after oral administration.

Hui Wang, Dong Yu, S. Agrawal, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Intratumoural immunotherapy: activation of nucleic acid sensing pattern recognition receptors

S. Agrawal, E. Kandimalla, 2019, Immuno-oncology technology.

RAGE Enhances TLR Responses through Binding and Internalization of RNA

E. Latz, S. Agrawal, T. Xiao, 2016, The Journal of Immunology.

Stabilized immune modulatory RNA compounds as agonists of Toll-like receptors 7 and 8

Dong Yu, S. Agrawal, T. Lan, 2007, Proceedings of the National Academy of Sciences.

Antisense and siRNA as agonists of Toll-like receptors

S. Agrawal, E. Kandimalla, 2004, Nature Biotechnology.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

Charles J. Vaske, Rohan N. Borkar, Brian D. Kelly, 2016, Journal of Immunotherapy for Cancer.

Dual Blockade of Cyclic AMP Response Element- (CRE) and AP-1-directed Transcription by CRE-transcription Factor Decoy Oligonucleotide

S. Agrawal, Y. Cho‐Chung, M. Nesterova, 1999, The Journal of Biological Chemistry.

Novel MDM2 p53‐Independent Functions Identified through RNA Silencing Technologies

Hui Wang, S. Agrawal, Ruiwen Zhang, 2005, Annals of the New York Academy of Sciences.

IMO-3100, an Antagonist of Toll-Like Receptors 7 and 9, Modulates Gene Expression and Regulatory Networks Induced by Ligands (48.25)

Dong Yu, S. Agrawal, E. Kandimalla, 2009, The Journal of Immunology.

Immunopharmacological and antitumor effects of second-generation immunomodulatory oligonucleotides containing synthetic CpR motifs.

Dong Yu, S. Agrawal, E. Kandimalla, 2004, International journal of oncology.

Modulation of the PC12 cell response to nerve growth factor by antisense oligonucleotide to amyloid precursor protein

C. Marotta, S. Agrawal, E. Humke, 1994, Cellular and Molecular Neurobiology.

Immunization with gp120-depleted whole killed HIV immunogen and a second-generation CpG DNA elicits strong HIV-specific responses in mice.

M. Clerici, S. Agrawal, D. Trabattoni, 2006, Vaccine.

The Cockayne syndrome group B DNA repair protein as an anti-cancer target.

S. Agrawal, D. Bregman, J. States, 2001, International journal of oncology.

Effect on embryos of injection of phosphorothioate-modified oligonucleotides into pregnant mice.

V. Metelev, S. Agrawal, G. Hampikian, 1993, Antisense Research and Development.

Peptide conjugation at the 5'-end of oligodeoxynucleotides abrogates toll-like receptor 9-mediated immune stimulatory activity.

S. Agrawal, E. Kandimalla, M. Dai, 2010, Bioconjugate chemistry.

Nucleoside Oxazaphospholidines as Novel Synthons in Oligonucleotide Synthesis

N. Ho, Dong Yu, S. Agrawal, 1995 .

Hoogsteen DNA duplexes of 3'-3'- and 5'-5'-linked oligonucleotides and trip formation with RNA and DNA pyrimidine single strands: experimental and molecular modeling studies.

S. Agrawal, E. Kandimalla, 1996, Biochemistry.

CRIPTO-1: a novel target for therapeutic intervention in human carcinoma.

N. Normanno, A. De Luca, C. Bianco, 2004, International journal of oncology.

Abstract B094: Intratumoral administration of IMO-2125, a novel TLR9 agonist, modulates the tumor microenvironment and exerts systemic antitumor activity alone and in combination with an anti-CTLA-4 mAb

S. Agrawal, Xianzhi Mao, Daqing Wang, 2016 .

Abstract B196: Intratumoral administration of IMO-2125, a novel TLR9 agonist, modulates tumor microenvironment and potentiates antitumor activity of anti-PD-1 mAb in a murine colon carcinoma model

S. Agrawal, Daqing Wang, J. DiMuzio, 2015 .

NMR structure of a 2',5' RNA favors A type duplex with compact C2'endo nucleotide repeat.

S. Agrawal, P. Patel, R. Hosur, 2001, Biochemical and biophysical research communications.

Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway

Sudhir Agrawal, Hui Wang, Hui Wang, 2005, Oncogene.

Antisense therapeutics.

S. Agrawal, Q. Zhao, 1998, Current opinion in chemical biology.

Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis, and cooperate with cytotoxic drugs in human cancer cell lines

G. Tortora, F. Ciardiello, J. Mendelsohn, 2001, International journal of cancer.

Application of XIAP Antisense to Cancer and Other Proliferative Disorders: Development of AEG35156/ GEM®640

S. Agrawal, J. Gillard, P. Winocour, 2005, Annals of the New York Academy of Sciences.

Protein kinase a riα antisense sensitization of radiation and androgen deprivation

S. Agrawal, J. Hannoun-levi, Z. Mu, 2004 .

Inhibition of 14q32 microRNA miR-495 reduces lesion formation, intimal hyperplasia and plasma cholesterol levels in experimental restenosis.

J. Jukema, P. Quax, S. Agrawal, 2017, Atherosclerosis.

8 – Nonradioactive Methods of in Situ Hybridization: Visualization of Neuroendocrine mRNA

P. Emson, S. Agrawal, H. Arai, 1989 .

Nonradioactive methods of in situ hybridization: visualization of neuroendocrine mRNA.

P. Emson, S. Agrawal, H. Arai, 1989, Methods in enzymology.

Intratumoral pharmacokinetics of oligonucleotides in a tissue-isolated tumor perfusion system.

M. Hashida, F. Yamashita, S. Agrawal, 2000, Antisense & nucleic acid drug development.

Solid-phase stereoselective synthesis of 2'-O-methyl-oligoribonucleoside phosphorothioates using nucleoside bicyclic oxazaphospholidines.

S. Agrawal, R. Iyer, M. Guo, 1998, Bioorganic & medicinal chemistry letters.

Specific inhibition of human immunodeficiency virus type 1 replication by antisense oligonucleotides: an in vitro model for treatment.

J. Lisziewicz, P. Zamecnik, S. Agrawal, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Antisense oligodeoxynucleotide phosphorothioate complementary to Gag mRNA blocks replication of human immunodeficiency virus type 1 in human peripheral blood cells.

J. Lisziewicz, J. Tang, S. Agrawal, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Comparative pharmacokinetics of antisense oligonucleotides.

S. Agrawal, J. Temsamani, 1996, Methods in molecular medicine.

Synergistic activation of p 53 by inhibition of MDM 2 expression and DNA damage

Jiandong Chen, Lihong Chen, S. Agrawal, 1997 .

Antisense oligonucleotides as modulators of pre-mRNA splicing.

S. Agrawal, R. Kole, H. Sierakowska, 2000, Methods in molecular biology.

Repair of thalassemic human b-globin mRNA in mammalian cells by antisense oligonucleotides ( RNA splicing y gene therapy )

S. Agrawal, R. Kole, H. Sierakowska, 1996 .

Oligodeoxynucleoside phosphoramidates and phosphorothioates as inhibitors of human immunodeficiency virus.

P. Zamecnik, S. Agrawal, M. Civeira, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Abstract 5652: Translational evidence of reactivated innate and adaptive immunity with intratumoral IMO-2125 in combination with systemic checkpoint inhibitors from a Phase I/II study in patients with anti-PD-1 refractory metastatic melanoma

J. Wargo, R. Murthy, R. Amaria, 2017 .

Intratumoral (i.t.) IMO-2125 (IMO), a TLR9 agonist, in combination with ipilimumab (ipi) in PD-(L)1 refractory melanoma (RM).

J. Wargo, R. Murthy, R. Amaria, 2017 .

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