P. Carmichael

发表

A comparison of gene expression changes in response to diethylstilbestrol treatment in wild-type and p53+/- hemizygous knockout mice using focussed arrays.

J. Caldwell, Mohd Nazil Salleh, P. Carmichael, 2003, Toxicology.

Implementing Toxicity Testing in the 21st Century (TT21C): Making safety decisions using toxicity pathways, and progress in a prototype risk assessment.

Yeyejide A. Adeleye, M. Andersen, R. Clewell, 2015, Toxicology.

Evaluation of an automated in vitro micronucleus assay in CHO-K1 cells.

P. Carmichael, A. Scott, W. Shi, 2007, Mutation research.

Integrating in vitro testing and physiologically-based pharmacokinetic (PBPK) modelling for chemical liver toxicity assessment-A case study of troglitazone.

P. Carmichael, Qiang Zhang, S. Peng, 2019, Environmental toxicology and pharmacology.

Identifying and Characterizing Stress Pathways of Concern for Consumer Safety in Next-Generation Risk Assessment

Paul Walker, Paul L Carmichael, Matthew Dent, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Next generation risk assessment of human exposure to anti-androgens using newly defined comparator compound values.

P. Carmichael, I. Rietjens, T. Moxon, 2021, Toxicology in vitro : an international journal published in association with BIBRA.

In vitro approaches to develop weight of evidence (WoE) and mode of action (MoA) discussions with positive in vitro genotoxicity results.

R Fautz, M. Aardema, P. Carmichael, 2007, Mutagenesis.

Classification of test agent-specific effects in the Syrian hamster embryo assay (pH 6.7) using infrared spectroscopy with computational analysis.

N. Fullwood, P. Carmichael, F. Martin, 2012, Mutagenesis.

Mechanisms of action of antiestrogens: relevance to clinical benefits and risks.

P. Carmichael, Paul L. Carmichael, 1998, Cancer investigation.

N-demethylation accompanies alpha-hydroxylation in the metabolic activation of tamoxifen in rat liver cells.

D. Phillips, A. Hewer, P. Carmichael, 1999, Carcinogenesis.

Integration of in vitro data from three dimensionally cultured HepaRG cells and physiologically based pharmacokinetic modeling for assessment of acetaminophen hepatotoxicity.

P. Carmichael, Qiang Zhang, Jun Zhao, 2020, Regulatory toxicology and pharmacology : RTP.

Mechanisms of Hormonal Carcinogenesis in the p53+/- Hemizygous Knockout Mouse: Studies With Diethylstilbestrol

J. Caldwell, J. Caldwell, P. Carmichael, 2001, Toxicologic pathology.

Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity.

W. Zhou, P. Carmichael, Qiang Zhang, 2017, Toxicology letters.

Mechanisms of Chemical Carcinogenesis

N. Gooderham, P. Carmichael, 2007 .

An appraisal of telomerase activity in benign prostatic hyperplasia

M. Pavone-Macaluso, P. Carmichael, E. Caldarera, 2000, The Prostate.

The way forward for assessing the human health safety of cosmetics in the eu workshop proceedings.

T. Vanhaecke, V. Rogiers, A. Worth, 2020, Toxicology.

A Next-Generation Risk Assessment Case Study for Coumarin in Cosmetic Products

P. Carmichael, Mi-Young Lee, T. Moxon, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

mRNA transfection retrofits cell-based assays with xenobiotic metabolism.

Mi-Young Lee, Steven O Simmons, Paul L Carmichael, 2018, Journal of pharmacological and toxicological methods.

A PGC-1α-Mediated Transcriptional Network Maintains Mitochondrial Redox and Bioenergetic Homeostasis against Doxorubicin-Induced Toxicity in Human Cardiomyocytes: Implementation of TT21C.

P. Carmichael, Qiang Zhang, C. Westmoreland, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Analysis of tamoxifen and its metabolites by on-line capillary electrophoresis-electrospray ionization mass spectrometry employing nonaqueous media containing surfactants.

R. Cole, P. Carmichael, G. K. Poon, 1996, Analytical chemistry.

A human-derived prostate co-culture microtissue model using epithelial (RWPE-1) and stromal (WPMY-1) cell lines.

K. Boekelheide, P. Carmichael, A. Amin, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

Induction of activating mutations in the human c‐Ha‐ras‐1 proto‐oncogene by oxygen free radicals

D. Phillips, P. Carmichael, M. Du, 1994, Molecular carcinogenesis.

Activation of tamoxifen and its metabolite alpha-hydroxytamoxifen to DNA-binding products: comparisons between human, rat and mouse hepatocytes.

D. Phillips, A. Hewer, I. Hardcastle, 1996, Carcinogenesis.

Lack of evidence from HPLC 32P-post-labelling for tamoxifen-DNA adducts in the human endometrium.

T. Bourne, P. Neven, D. Phillips, 1999, Carcinogenesis.

Tamoxifen and the female genital tract.

P. Neven, P. Carmichael, A. Ugwumadu, 1998, International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.

Tamoxifen does not form detectable DNA adducts in white blood cells of breast cancer patients.

D. Phillips, A. Hewer, P. Carmichael, 1996, Carcinogenesis.

Electrospray ionization-tandem mass spectrometry and 32P-postlabeling analyses of tamoxifen-DNA adducts in humans.

D. Phillips, A. Hewer, P. Carmichael, 2004, Journal of the National Cancer Institute.

DNA damage in breast epithelial cells: detection by the single-cell gel (comet) assay and induction by human mammary lipid extracts.

B. Gusterson, S. Venitt, D. Phillips, 1997, Carcinogenesis.

A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: genotoxicity. A COLIPA analysis.

Nicola J Hewitt, Andreas Schepky, Kerstin Reisinger, 2010, Regulatory toxicology and pharmacology : RTP.

Thresholds for genotoxins and their application in risk assessment.

M. Kirsch‐Volders, P. Carmichael, H. Vrijhof, 2009, Mutation research.

Toxicity Testing in the 21st Century: Defining New Risk Assessment Approaches Based on Perturbation of Intracellular Toxicity Pathways

Melvin E. Andersen, Paul L. Carmichael, Sudin Bhattacharya, 2011, PloS one.

Case Studies in Cellular Stress: Defining Adversity/Adaptation Tipping Points

Yeyejide A. Adeleye, Russell S. Thomas, I. Shah, 2017 .

Next Generation Risk Assessment of the Anti-Androgen Flutamide Including the Contribution of Its Active Metabolite Hydroxyflutamide

P. Carmichael, I. Rietjens, Hequn Li, 2022, Frontiers in Toxicology.

Toward an integrated strategy to understand mechanisms across 2 species for chemical safety assessment

James B. Brown, Timothy E. H. Allen, R. Judson, 2019 .

Lack of genotoxicity of tamoxifen in human endometrium.

P. Neven, D. Phillips, A. Hewer, 1996, Cancer research.

Metabolic activation and DNA binding of food mutagens and other environmental carcinogens in human mammary epithelial cells.

B. Gusterson, D. Phillips, P. Carmichael, 1996, Carcinogenesis.

The carcinoGENOMICS project: critical selection of model compounds for the development of omics-based in vitro carcinogenicity screening assays.

Raffaella Corvi, Susanna-Assunta Sansone, Philippe Rocca-Serra, 2008, Mutation research.

Lipid peroxidation-induced etheno-DNA adducts in the liver of patients with the genetic metal storage disorders Wilson's disease and primary hemochromatosis.

H. Bartsch, D. Phillips, P. Carmichael, 1998, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

The Syrian hamster embryo (SHE) assay (pH 6.7): mechanisms of cell transformation and application of vibrational spectroscopy to objectively score endpoint alterations.

N. Fullwood, P. Carmichael, F. Martin, 2012, Mutagenesis.

Gene Expression Profiling of p53+/‐ Knockout and Wild‐type Mice Following Diethylstilbestrol Administration

Y. Taufiq-Yap, Mohd Nazil Salleh, P. Carmichael, 2004, IUBMB life.

Detection of telomerase activity in human prostate: a diagnostic marker for prostatic cancer?

S. Venitt, P. Carmichael, G. Muir, 1997, British journal of urology.

Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells.

P. Carmichael, Lei Chang, P. Xu, 2022, Toxicology and applied pharmacology.

Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway.

P. Carmichael, Qiang Zhang, Jun Zhao, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

Non-cytotoxic concentrations of acetaminophen induced mitochondrial biogenesis and antioxidant response in HepG2 cells.

A. White, P. Carmichael, Qiang Zhang, 2016, Environmental toxicology and pharmacology.

Suppression of NRF2-ARE activity sensitizes chemotherapeutic agent-induced cytotoxicity in human acute monocytic leukemia cells.

M. Andersen, R. Clewell, T. Zhou, 2016, Toxicology and applied pharmacology.

Identification of the major tamoxifen-deoxyguanosine adduct formed in the liver DNA of rats treated with tamoxifen.

D. Phillips, A. Hewer, I. Hardcastle, 1996, Cancer research.

Predictive Performance of Next Generation Human Physiologically Based Kinetic (PBK) Models Based on In Vitro and In Silico Input Data

E. Fabian, P. Carmichael, T. Moxon, 2022 .

Percutaneous penetration and genotoxicity of 4,4'-methylenedianiline through rat and human skin in vitro.

P. Carmichael, C. Benson, S. Kenyon, 2004, Toxicology.

Different Levels of Polybrominated Diphenyl Ethers (PBDEs) and Chlorinated Compounds in Breast Milk from Two U.K. Regions

G. O. Thomas, J. Nicholson, P. Carmichael, 2004, Environmental health perspectives.

Metabonomics and the endocrine system

P. Carmichael, S. Mitchell, 2005, Molecular and Cellular Endocrinology.

Mechanisms of Chemical Carcinogenesis

N. Gooderham, P. Carmichael, 2007 .

The phosphoproteome is a first responder in tiered cellular adaptation to chemical stress followed by proteomics and transcriptomics alteration

P. Carmichael, Qiang Zhang, Lei Chang, 2022, bioRxiv.

Evidence for the involvement of a bis-diol-epoxide in the metabolic activation of dibenz[a,h]anthracene to DNA-binding species in mouse skin.

F. Oesch, D. Phillips, P. Carmichael, 1993, Cancer research.

An assessment of the performance of an automated scoring system (Cellomics) for the in vitro micronucleus assay in CHO-K1 cells

Sophie Malcomber, Paul L. Carmichael, Claire Moore, 2007 .

In silico predictions of Ames test mutagenicity: An integrated approach

Jin Li, Sophie Malcomber, Sandeep Modi, 2010 .

Flutamide Induces Hepatic Cell Death and Mitochondrial Dysfunction via Inhibition of Nrf2-Mediated Heme Oxygenase-1

W. Zhou, P. Carmichael, Qiang Zhang, 2018, Oxidative medicine and cellular longevity.

alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes.

D. Phillips, A. Hewer, P. Carmichael, 1994, Cancer research.

Analysis of the polycyclic aromatic hydrocarbon content of petrol and diesel engine lubricating oils and determination of DNA adducts in topically treated mice by 32P-postlabelling.

D. Phillips, P. Carmichael, G. Grimmer, 1990, Carcinogenesis.

Are Non-animal Systemic Safety Assessments Protective? A Toolbox and Workflow

P. Carmichael, M. Dent, Sophie Malcomber, 2022, Toxicological sciences : an official journal of the Society of Toxicology.

Paving the way for application of next generation risk assessment to safety decision-making for cosmetic ingredients

S. H. Bennekou, V. Rogiers, K. Boekelheide, 2021, Regulatory toxicology and pharmacology : RTP.

Differences in susceptibility between crystallins and non-lenticular proteins to copper and H2O2-mediated peptide bond cleavage.

P. Carmichael, A. Hipkiss, 1991, Free radical research communications.

P. Carmichael, A. Hipkiss, 1989, Mechanisms of Ageing and Development.

Using transcriptomics, proteomics and phosphoproteomics as new approach methodology (NAM) to define biological responses for chemical safety assessment.

P. Carmichael, Lei Chang, P. Xu, 2022, Chemosphere.

Classification of agents using Syrian hamster embryo (SHE) cell transformation assay (CTA) with ATR-FTIR spectroscopy and multivariate analysis.

P. Carmichael, F. Martin, J. Trevisan, 2015, Mutagenesis.

The Radioactive Phosphorus Test in Ophthalmology

P. Carmichael, I. Leopold, 1960 .

Genotoxic effects of subacute treatments with wood dust extracts on the nasal epithelium of rats: Assessment by the micronucleus and32P-postlabelling

P. Carmichael, E. Nelson, K. Norpoth, 2005, Archives of Toxicology.

Generation of putative intrastrand cross-links and strand breaks in DNA by transition metal ion-mediated oxygen radical attack.

D. Phillips, D. Lloyd, P. Carmichael, 1997, Chemical research in toxicology.

Assessing dose-dependent differences in DNA-damage, p53 response and genotoxicity for quercetin and curcumin.

Melvin E Andersen, Rebecca A Clewell, Andrew White, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

In vitro predictions of skin absorption of caffeine, testosterone, and benzoic acid: a multi-centre comparison study.

P Sartorelli, L Montomoli, S C Wilkinson, 2004, Regulatory toxicology and pharmacology : RTP.

A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity.

Bertrand Desprez, Martina Klaric, Gladys Ouédraogo, 2019, Toxicology in vitro : an international journal published in association with BIBRA.

DNA adduct formation in mice following treatment with used engine oil and identification of some of the major adducts by 32P-postlabelling.

D. Phillips, A. Hewer, P. Carmichael, 1992, Cancer letters.

IRootLab: a free and open-source MATLAB toolbox for vibrational biospectroscopy data analysis

Plamen P. Angelov, Paul L. Carmichael, Francis L. Martin, 2013, Bioinform..

Towards a non-animal risk assessment for anti-androgenic effects in humans.

Kevin C. Jones, Paul L. Carmichael, Francis L. Martin, 2015, Environment international.

International Harmonization and Cooperation in the Validation of Alternative Methods.

Xingfen Yang, W. Casey, A. Nishikawa, 2016, Advances in experimental medicine and biology.

Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents.

M. Andersen, R. Clewell, B. Engelward, 2016, Mutation research. Reviews in mutation research.

Cell transformation assays for prediction of carcinogenic potential: state of the science and future research needs

Paul L. Carmichael, Albrecht Poth, Leonard M. Schechtman, 2011, Mutagenesis.

Detection of low levels of DNA damage arising from exposure of humans to chemical carcinogens.

P. Carmichael, 1998, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Detection of bulky DNA lesions in the liver of patients with Wilson's disease and primary haemochromatosis.

D. Phillips, A. Hewer, P. Carmichael, 1995, Mutation research.

Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance

Paul L. Carmichael, Rebecca C. Fry, J. Peter Svensson, 2011, BMC Systems Biology.

Determination of genetic toxicity and potential carcinogenicity in vitro--challenges post the Seventh Amendment to the European Cosmetics Directive.

P. Carmichael, A. Scott, C. Westmoreland, 2006, Mutagenesis.

Beyond AOPs: A Mechanistic Evaluation of NAMs in DART Testing

P. Carmichael, M. Dent, Hequn Li, 2022, Frontiers in Toxicology.

Gene expression changes induced by estrogen and selective estrogen receptor modulators in primary-cultured human endometrial cells: signals that distinguish the human carcinogen tamoxifen.

P. Carmichael, T. Orton, L. Gold, 2005, Toxicology.

Vision of a near future: Bridging the human health-environment divide. Toward an integrated strategy to understand mechanisms across species for chemical safety assessment.

Imran Shah, Andrew White, Francesco Falciani, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

Genomic Phenotyping by Barcode Sequencing Broadly Distinguishes between Alkylating Agents, Oxidizing Agents, and Non-Genotoxic Agents, and Reveals a Role for Aromatic Amino Acids in Cellular Recovery after Quinone Exposure

L. Samson, J. Svensson, P. Carmichael, 2013, PloS one.

Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities-Report from an ECVAM workshop.

Raffaella Corvi, Peter Kasper, Cyrille Krul, 2009, Mutation research.

Next generation risk assessment (NGRA): Bridging in vitro points-of-departure to human safety assessment using physiologically-based kinetic (PBK) modelling - A case study of doxorubicin with dose metrics considerations.

P. Carmichael, Qiang Zhang, B. Nicol, 2021, Toxicology in vitro : an international journal published in association with BIBRA.

DNA adducts in human breast tissue: association with N-acetyltransferase-2 (NAT2) and NAT1 genotypes.

D. Phillips, P. Carmichael, H. Marquardt, 1998, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Pathways of Toxicity.

Thomas Hartung, Roded Sharan, Melvin E Andersen, 2014, ALTEX.

Analysis of p53 mutations for a mutational signature in human intrahepatic cholangiocarcinoma.

H. Thomas, S. Taylor-Robinson, Shahid A. Khan, 2006, International journal of oncology.

Biospectroscopy to metabolically profile biomolecular structure: a multistage approach linking computational analysis with biomarkers.

Francis L Martin, Jemma G. Kelly, Pierre L Martin-Hirsch, 2011, Journal of proteome research.

Comparison of the formation of 8-hydroxy-2'-deoxyguanosine and single- and double-strand breaks in DNA mediated by fenton reactions.

D. Phillips, D. Lloyd, P. Carmichael, 1998, Chemical research in toxicology.

Identification of Estrogen-responsive Genes in p53+/- Knockout and Isogenic Wild-type Parent Strain Mice by CDNA Macroarray Analysis

Y. Taufiq-Yap, Mohd Nazil Salleh, P. Carmichael, 2004 .

Pathway Based Toxicology and Fit-for-Purpose Assays.

Melvin E Andersen, Rebecca A Clewell, Yeyejide Adeleye, 2016, Advances in experimental medicine and biology.

Profiling Dose-Dependent Activation of p53-Mediated Signaling Pathways by Chemicals with Distinct Mechanisms of DNA Damage

Melvin E. Andersen, Rebecca A. Clewell, Patrick D. McMullen, 2014, Toxicological sciences : an official journal of the Society of Toxicology.

Reduction of misleading ("false") positive results in mammalian cell genotoxicity assays. I. Choice of cell type.

Katie Smith, David Kirkland, Stefan Pfuhler, 2012, Mutation research.

Reduction of misleading ("false") positive results in mammalian cell genotoxicity assays. II. Importance of accurate toxicity measurement.

Katie Smith, David Kirkland, Stefan Pfuhler, 2012, Mutation research.

Adaptive Posttranslational Control in Cellular Stress Response Pathways and Its Relationship to Toxicity Testing and Safety Assessment.

Melvin E Andersen, Rebecca A Clewell, Sudin Bhattacharya, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Effect of oxygen weaning in retrolental fibroplasia.

P. Carmichael, R. Bedrossian, J. Ritter, 1955, A.M.A. archives of ophthalmology.

Evaluation of histochemical techniques for carbonic anhydrase in ocular tissues.

P. Carmichael, I. Leopold, C. Hamblin, 1957, A.M.A. archives of ophthalmology.

Reduction of misleading ("false") positive results in mammalian cell genotoxicity assays. III: sensitivity of human cell types to known genotoxic agents.

Katie Smith, David Kirkland, Stefan Pfuhler, 2014, Mutation research. Genetic toxicology and environmental mutagenesis.

Modulation of endometrial transforming growth factor β (TGFβ) by tamoxifen

P. Neven, P. Carmichael, J. Pole, 2000 .

Identification of transcriptional biomarkers induced by SERMS in human endometrial cells using multivariate analysis of DNA microarrays

J. Griffin, P. Carmichael, J. Pole, 2004, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

The significance of the 32-P uptake test in the diagnosis of posterior uveal melanomas.

J. Federman, P. Carmichael, J. Shields, 1975, Transactions. Section on Ophthalmology. American Academy of Ophthalmology and Otolaryngology.

Retinopathy of Prematurity (Retrolental Fibroplasia) and Oxygen*: Part I. Clinical Study: Part II. Further Observations on the Disease

P. Carmichael, R. Bedrossian, J. Ritter, 1954 .

The passage of trimethylamine across rat and human skin.

P. Carmichael, R. Waring, S. Mitchell, 2004, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Implementing organ-on-chip in a next-generation risk assessment of chemicals: a review

H. Bouwmeester, P. Carmichael, Sophie Malcomber, 2022, Archives of Toxicology.

Risk assessment of genotoxic mutagens with thresholds: a brief introduction.

M. Kirsch‐Volders, P. Carmichael, D. Kirkland, 2009, Mutation research.

DNA adducts, detected by 32P postlabelling, in human cholangiocarcinoma

H. Thomas, S. Taylor-Robinson, P. Carmichael, 2003, Gut.

Genotoxicity of human mammary lipid.

S. Venitt, D. Phillips, P. Carmichael, 1996, Cancer research.

Detection and characterization by 32P-postlabelling of DNA adducts induced by a Fenton-type oxygen radical-generating system.

D. Phillips, P. Carmichael, M. N. Shé, 1992, Carcinogenesis.

DNA adducts in human and mouse skin maintained in short-term culture and treated with petrol and diesel engine lubricating oils.

D. Phillips, P. Carmichael, M. Ni Shé, 1991, Cancer letters.

Employing Dietary Comparators to Perform Risk Assessments for Anti-Androgens Without Using Animal Data

Hequn Li, Paul L Carmichael, P. Carmichael, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Integrated in silico approaches for the prediction of Ames test mutagenicity

Jin Li, Andrew White, Sophie Malcomber, 2012, Journal of Computer-Aided Molecular Design.

I.3 An epigenetic mechanism for tamoxifen-associated uterine carcinogenesis?

P. Neven, P. Carmichael, J. Mills, 1998 .

Next generation risk assessment of human exposure to estrogens using safe comparator compound values based on in vitro bioactivity assays

P. Carmichael, I. Rietjens, Hequn Li, 2023, Archives of Toxicology.

Novel approaches to derive points of departure for food chemical risk assessment

Sara Levorato, Ivonne M. C. M. Rietjens, Paul L. Carmichael, 2019, Current Opinion in Food Science.

Microphysiological Systems Evaluation: Experience of TEX-VAL Tissue Chip Testing Consortium.

Courtney M. Sakolish, Nisha S. Sipes, I. Rusyn, 2022, Toxicological sciences : an official journal of the Society of Toxicology.

The Alginate Immobilization of Metabolic Enzymes (AIME) Platform Retrofits an Estrogen Receptor Transactivation Assay with Metabolic Competence.

Todd J. Zurlinden, Russell S. Thomas, P. Carmichael, 2020, Toxicological sciences : an official journal of the Society of Toxicology.

Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop

Andrew Worth, Bertrand Desprez, Martina Klaric, 2019, Regulatory toxicology and pharmacology : RTP.

Assuring safety without animal testing: Unilever's ongoing research programme to deliver novel ways to assure consumer safety.

Gavin Maxwell, Cameron MacKay, Julia Fentem, 2010, ALTEX.

Correspondence regarding M. Sharma et al., "Antioxidant inhibits tamoxifen-DNA adducts in endometrial explant culture".

P. Carmichael, K. Brown, 2003, Biochemical and biophysical research communications.

Extracting biological information with computational analysis of Fourier-transform infrared (FTIR) biospectroscopy datasets: current practices to future perspectives.

Francis L Martin, Plamen P Angelov, Paul L Carmichael, 2012, The Analyst.

Accelerating the Development of 21st-Century Toxicology: Outcome of a Human Toxicology Project Consortium Workshop

Melvin E. Andersen, Michael P. Holsapple, Paul L. Carmichael, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Cellular environment of metabolites and a metabonomic study of tamoxifen in endometrial cells using gradient high resolution magic angle spinning 1H NMR spectroscopy.

J. Griffin, J. Nicholson, P. Carmichael, 2003, Biochimica et biophysica acta.

Assuring Consumer Safety without Animal Testing: A Feasibility Case Study for Skin Sensitisation

Cameron Mackay, Guy Warner, Gavin Maxwell, 2008, Alternatives to laboratory animals : ATLA.

Non-Animal Approaches for Consumer Safety Risk Assessments: Unilever's Scientific Research Programme

P. Carmichael, J. Fentem, Michael Davies, 2009, Alternatives to laboratory animals : ATLA.

Can case study approaches speed implementation of the NRC report: "toxicity testing in the 21st century: a vision and a strategy?".

Harvey J Clewell, Melvin E Andersen, Kim Boekelheide, 2011, ALTEX.

Syrian Hamster Embryo (SHE) cell transformation assay with and without X-ray irradiation of feeder cells using Di(2-ethylhexyl)phthalate (DEHP) and N-nitroso-N-methylnitroguanidine (MNNG).

P. Carmichael, A. Scott, S. Bruce, 2010, Mutation research.

Discrimination of a transformation phenotype in Syrian golden hamster embryo (SHE) cells using ATR-FTIR spectroscopy.

Francis L Martin, Paul L Carmichael, Michael J Walsh, 2009, Toxicology.

The COLIPA skin metabolism project: Do in vitro alternatives comprise adequate detoxification capacities for chemical testing in skin?

R. Edwards, P. Carmichael, C. Goebel, 2010 .

Exploring new approaches to assess safety without animal testing

G. Warner, P. Carmichael, J. Fentem, 2006 .

Chemical safety without animals

P. Carmichael, C. Westmoreland, 2014, Nature Biotechnology.

Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance.

G. Johnson, S. Doak, G. Jenkins, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Mutation Research/Genetic Toxicology and Environmental Mutagenesis

M. Kirsch‐Volders, P. Carmichael, D. Kirkland, 2009 .

Development of a human keratinocyte cell line that is up-regulated for the expression of superoxide dismutase 1 (SOD1)

P. Carmichael, Sophie Malcomber, A. Scott, 2006 .

Microspectroscopy of spectral biomarkers associated with human corneal stem cells

Jean Susini, Paul L. Carmichael, Jemma G. Kelly, 2010, Molecular vision.

VI.6 Detection of DNA adducts in the human endometrium: a lack of evidence

T. Bourne, P. Neven, D. Phillips, 1998 .

Food for Thought ... Can Case Study Approaches Speed Implementation of the NRC Report : “ Toxicity Testing in the 21 st Century : A Vision and a Strategy ? ”

Melvin E. Andersen, Harvey J. Clewell, Paul L. Carmichael, 2011 .

Isolating stem cells in the inter-follicular epidermis employing synchrotron radiation-based Fourier-transform infrared microspectroscopy and focal plane array imaging

Paul L. Carmichael, Katia Wehbe, Gianfelice Cinque, 2012, Analytical and Bioanalytical Chemistry.

Pathways of Toxicity.

Yeyejide A. Adeleye, Scott M. Auerbach, M. Kanehisa, 2014, ALTEX.

A tiered approach to the use of alternatives to animal testing for the safety assessment of cosmetics: genotoxicity. A COLIPA analysis.

M. Aardema, P. Carmichael, N. Hewitt, 2010, Regulatory toxicology and pharmacology : RTP.

Syrian hamster embryo (SHE) assay (pH 6.7) coupled with infrared spectroscopy and chemometrics towards toxicological assessment.

Francis L Martin, Plamen P Angelov, Paul L Carmichael, 2010, The Analyst.

Validation of a high throughput bacterial screen for mutagenicity: Incorporation of Salmonella typhimurium strain TA102

P. Carmichael, A. Scott, S. Windebank, 2006 .

Correlation of tumors with DNA adducts from methyl eugenol and tamoxifen in rats.

P. Carmichael, N. Crooks, W. Waddell, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

A metabolomic and multivariate statistical process to assess the effects of genotoxins in Saccharomyces cerevisiae.

S. Oliver, J. Griffin, P. Carmichael, 2009, Molecular bioSystems.

Biospectroscopy to metabolically profile biomolecular structure: a multistage approach linking computational analysis with biomarkers.

Jemma G. Kelly, H. Pollock, P. Carmichael, 2011, Journal of proteome research.

Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents.

Christopher D. Heinen, Yeyejide A. Adeleye, M. Andersen, 2016, Mutation research. Reviews in mutation research.

Francis L Martin, Plamen P Angelov, Paul L Carmichael, 2014, Journal of biophotonics.

mRNA transfection retrofits cell-based assays with xenobiotic metabolism.

Russell S. Thomas, S. Simmons, P. Carmichael, 2018, Journal of pharmacological and toxicological methods.