A. Haimovitz-Friedman

H. Bartelink, A. Haimovitz-Friedman, S. Zerp, 1998, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Sequestration and Release of Basic Fibroblast Growth Factor a

M. Klagsbrun, A. Haimovitz-Friedman, Z. Fuks, 1991, Annals of the New York Academy of Sciences.

Cancer esearch or and Stem Cell Biology act of Stromal Sensitivity on Radiation Response R umors Implanted in SCID Hosts Revisited

C. Cordon-Cardo, T. Thin, A. Haimovitz-Friedman, 2010 .

Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice.

W. Arap, A. Haimovitz-Friedman, Z. Fuks, 2012, The Journal of clinical investigation.

Nitroxides Tempol and Tempo Induce Divergent Signal Transduction Pathways in MDA-MB 231 Breast Cancer Cells*

A. Haimovitz-Friedman, D. Ehleiter, U. Kasid, 1998, The Journal of Biological Chemistry.

Ceramide synthase inhibitor fumonisin B1 inhibits apoptotic cell death in SCC17B human head and neck squamous carcinoma cells after Pc4 photosensitization

A. Bielawska, G. Divine, M. Korbelik, 2014, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 selectively potentiates radiation response of human tumors in nude mice, with a marked improvement in therapeutic index.

M. Kris, V. Miller, J. Chen, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Immunomodulatory Effects of Stereotactic Body Radiation Therapy: Preclinical Insights and Clinical Opportunities.

W. Tomé, P. Tran, T. DeWeese, 2019, International journal of radiation oncology, biology, physics.

In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2′-deoxy-2′-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models

J. Humm, M. Lowery, A. Haimovitz-Friedman, 2017, Molecular Imaging and Biology.

Microvascular function regulates intestinal crypt response to radiation.

E. Venkatraman, A. Haimovitz-Friedman, Z. Fuks, 2003, Cancer research.

Manipulating Oxidative Stress Following Ionizing Radiation

A. Haimovitz-Friedman, E. Jaimes, A. Mizrachi, 2020, Journal of cellular signaling.

Radiation therapy causes loss of dermal lymphatic vessels and interferes with lymphatic function by TGF-beta1-mediated tissue fibrosis.

A. Haimovitz-Friedman, B. Mehrara, J. Zampell, 2010, American journal of physiology. Cell physiology.

Pazopanib radio-sensitization of human sarcoma tumors

G. Schwartz, S. Powell, E. de Stanchina, 2018, Oncotarget.

Chemotherapy-induced acute vascular injury involves intracellular generation of ROS via activation of the acid sphingomyelinase pathway.

A. Popovtzer, A. Haimovitz-Friedman, I. Ben-Aharon, 2021, Cellular signalling.

Expression of basic fibroblast growth factor in normal human tissues.

C. Cordon-Cardo, A. Haimovitz-Friedman, Z. Fuks, 1990, Laboratory investigation; a journal of technical methods and pathology.

Transforming growth factor‐β1 stimulates macrophage urokinase expression and release of matrix‐bound basic fibroblast growth factor

T. McCaffrey, A. Haimovitz-Friedman, D. Falcone, 1993, Journal of cellular physiology.

Natural Ceramide Reverses Fas Resistance of Acid Sphingomyelinase −/− Hepatocytes*

A. Haimovitz-Friedman, Z. Fuks, R. Kolesnick, 2001, The Journal of Biological Chemistry.

The Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor ZD 1839 Selectively Potentiates Radiation Response of Human Tumors in Nude Mice , with a Marked Improvement in Therapeutic Index 1

M. Kris, V. Miller, F. Sirotnak, 2003 .

Intravenous basic fibroblast growth factor protects the lung but not mediastinal organs against radiation-induced apoptosis in vivo.

C. Cordon-Cardo, A. Haimovitz-Friedman, A. Alfieri, 1995, The cancer journal from Scientific American.

Macrophage and foam cell release of matrix-bound growth factors. Role of plasminogen activation.

T. McCaffrey, A. Haimovitz-Friedman, A. C. Nicholson, 1993, The Journal of biological chemistry.

Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring

A. Haimovitz-Friedman, Z. Fuks, J. Tilly, 2002, Nature Medicine.

Effects of extracellular matrix on the response of endothelial cells to radiation in vitro.

M. Andreeff, A. Haimovitz-Friedman, Z. Fuks, 1992, European journal of cancer.

Cell-intrinsic ceramides determine T cell function during melanoma progression

J. Buer, F. Schumacher, A. Haimovitz-Friedman, 2022, bioRxiv.

Potentiation of apoptosis by treatment with the protein kinase C-specific inhibitor safingol in mitomycin C-treated gastric cancer cells.

P. Maslak, G. Schwartz, A. Albino, 1995, Journal of the National Cancer Institute.

Expression of heparanase by platelets and circulating cells of the immune system: possible involvement in diapedesis and extravasation.

I. Cohen, A. Haimovitz-Friedman, Z. Fuks, 1992, Invasion & metastasis.

PKCα activation down-regulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo

A. Haimovitz-Friedman, Z. Fuks, R. Kolesnick, 2009 .

PKC α activation downregulates ATM and radio-sensitizes androgen-sensitive human prostate cancer cells in vitro and in vivo

A. Haimovitz-Friedman, Z. Fuks, R. Kolesnick, 2022 .

Radiation-Induced Microvascular Injury as a Mechanism of Salivary Gland Hypofunction and Potential Target for Radioprotectors

James B. Mitchell, N. Katabi, A. Haimovitz-Friedman, 2016, Radiation Research.

The role of the sphingomyelin pathway and protein kinase C in radiation-induced cell kill.

A. Haimovitz-Friedman, Z. Fuks, R. Kolesnick, 1995, Important advances in oncology.

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

L. Zon, S. Grant, M. Birrer, 1996, Nature.

Targeting acid sphingomyelinase with anti-angiogenic chemotherapy.

K. Manova, A. Bielawska, A. Haimovitz-Friedman, 2017, Cellular signalling.

Sildenafil Protects Endothelial Cells From Radiation-Induced Oxidative Stress

A. Haimovitz-Friedman, A. Lippert, L. Incrocci, 2019, The journal of sexual medicine.

Phosphorylation state of Ser165 in α-tubulin is a toggle switch that controls proliferating human breast tumors.

E. de Stanchina, A. Haimovitz-Friedman, S. Rotenberg, 2018, Cellular signalling.

Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring

A. Haimovitz-Friedman, Z. Fuks, J. Tilly, 2002, Nature Medicine.

12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase.

A. Haimovitz-Friedman, Z. Fuks, W. Liao, 1998, Cancer research.

Reversal of radiation resistance in LNCaP cells by targeting apoptosis through ceramide synthase.

A. Haimovitz-Friedman, Z. Fuks, W. Liao, 1999, Cancer research.

Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice

Zvi Fuks, Carlos Cordon-Cardo, C. Cordon-Cardo, 2001, Science.

The cyclin-dependent kinase inhibitor flavopiridol potentiates gamma-irradiation-induced apoptosis in colon and gastric cancer cells.

M. Gonen, G. Schwartz, C. Jung, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Ceramide synthases 2, 5, and 6 confer distinct roles in radiation-induced apoptosis in HeLa cells.

A. Haimovitz-Friedman, Z. Fuks, R. Kolesnick, 2010, Cellular signalling.

Ceramide Biogenesis Is Required for Radiation-Induced Apoptosis in the Germ Line of C. elegans

A. Haimovitz-Friedman, Z. Fuks, R. Kolesnick, 2008, Science.

Acid Sphingomyelinase–Deficient Human Lymphoblasts and Mice Are Defective in Radiation-Induced Apoptosis

Seamus J. Martin, D. Green, C. Cordon-Cardo, 1996, Cell.

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

A. Haimovitz-Friedman, Z. Fuks, R. Persaud, 1994, The Journal of experimental medicine.

Activation of platelet heparitinase by tumor cell-derived factors.

A. Haimovitz-Friedman, Z. Fuks, V. Schirrmacher, 1991, Blood.

Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo.

J. Schwartz, C. Cordon-Cardo, A. Haimovitz-Friedman, 1994, Cancer research.

BASIC AND TRANSLATIONAL — ALIMENTARY TRACT Crypt Base Columnar Stem Cells in Small Intestines of Mice Are Radioresistant

H. Clevers, T. Thin, A. Haimovitz-Friedman, 2012 .

Photobiomodulation effects on head and neck squamous cell carcinoma (HNSCC) in an orthotopic animal model

A. Haimovitz-Friedman, J. Epstein, A. Barasch, 2019, Supportive Care in Cancer.

ATM regulates target switching to escalating doses of radiation in the intestines

A. Haimovitz-Friedman, Z. Fuks, R. Kolesnick, 2005, Nature Medicine.

Bax and Bak do not exhibit functional redundancy in mediating radiation-induced endothelial apoptosis in the intestinal mucosa.

C. Cordon-Cardo, E. Cheng, A. Haimovitz-Friedman, 2008, International journal of radiation oncology, biology, physics.

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

K. Scotto, A. Haimovitz-Friedman, M. Verheij, 1995, Cell.

Correction: Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors

S. Powell, A. Haimovitz-Friedman, Z. Fuks, 2016, PloS one.

Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors

S. Powell, A. Haimovitz-Friedman, Z. Fuks, 2015, PloS one.

Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma

J. Humm, J. Baselga, J. Healey, 2017, Nature Communications.

Disruption of Abi1/Hssh3bp1 expression induces prostatic intraepithelial neoplasia in the conditional Abi1/Hssh3bp1 KO mice

Gary D Bader, J. Reimand, J. Koutcher, 2012, Oncogenesis.

Safingol (l-threo-sphinganine) induces autophagy in solid tumor cells through inhibition of PKC and the PI3-kinase pathway

G. Schwartz, Jesse Coward, A. Haimovitz-Friedman, 2009, Autophagy.

Lipopolysaccharide Induces Disseminated Endothelial Apoptosis Requiring Ceramide Generation

C. Cordon-Cardo, A. Haimovitz-Friedman, Z. Fuks, 1997, The Journal of experimental medicine.

Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation

John Calvin Reed, A. Haimovitz-Friedman, Z. Fuks, 2011, PloS one.

Basic fibroblast growth factor confers growth inhibition and mitogen-activated protein kinase activation in human breast cancer cells.

A. Haimovitz-Friedman, Z. Fuks, R. Persaud, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Radiation Damage in Endothelial Cells Autocrine Effects of Fibroblast Growth Factor in Repair of Updated

A. Haimovitz-Friedman, Z. Fuks, I. Vlodavsky, 2006 .

The role of cytokines in radiation oncology.

D. Hallahan, R. Weichselbaum, D. Kufe, 1993, Important advances in oncology.

P-selectin is a nanotherapeutic delivery target in the tumor microenvironment

Prakrit V. Jena, C. Rudin, J. Baselga, 2016, Science Translational Medicine.

Host Acid Sphingomyelinase Regulates Microvascular Function Not Tumor Immunity

A. Haimovitz-Friedman, Z. Fuks, R. Kolesnick, 2004, Cancer Research.

Effects of irradiation on the release of growth factors from cultured bovine, porcine, and human endothelial cells.

A. Haimovitz-Friedman, Z. Fuks, D. Goodman, 1989, Cancer research.

Endothelial apoptosis initiates acute blood-brain barrier disruption after ionizing radiation.

Paul Chen, A. Haimovitz-Friedman, C. Wong, 2003, Cancer research.

A Combination of Radiation and the Hypoxia-Activated Prodrug Evofosfamide (TH-302) is Efficacious against a Human Orthotopic Pancreatic Tumor Model12

J. Humm, J. Deasy, K. Goodman, 2017, Translational oncology.

Radiation-induced gastrointestinal (GI) syndrome as a function of age

P. Paty, A. Haimovitz-Friedman, Z. Fuks, 2015, Cell Death Discovery.

Ceramide signaling in apoptosis.

A. Haimovitz-Friedman, Z. Fuks, R. Kolesnick, 1996, British medical bulletin.

Imaging Radiotherapy-Induced Apoptosis

T. Thin, A. Haimovitz-Friedman, M. Verheij, 2012, Radiation research.

Chemotherapeutic Agents-Induced Ceramide-Rich Platforms (CRPs) in Endothelial Cells and Their Modulation.

A. Haimovitz-Friedman, P. Nepali, 2021, Methods in molecular biology.

Radiation-induced signal transduction and stress response.

A. Haimovitz-Friedman, 1998, Radiation research.

A Ceramide-binding C1 Domain Mediates Kinase Suppressor of Ras Membrane Translocation

A. Haimovitz-Friedman, Z. Fuks, R. Kolesnick, 2009, Cellular Physiology and Biochemistry.

Regulation of ceramide synthase-mediated crypt epithelium apoptosis by DNA damage repair enzymes.

A. Haimovitz-Friedman, Z. Fuks, R. Kolesnick, 2010, Cancer research.

Anticancer therapy and apoptosis imaging.

A. Haimovitz-Friedman, M. Verheij, T. Yang, 2012, Experimental oncology.

Induction of growth factor genes in endothelial cells by ionizing radiation

A. Haimovitz-Friedman, Z. Fuks, M. McLoughlin, 1995 .

Conformationally constrained analogues of diacylglycerol. 29. Cells sort diacylglycerol-lactone chemical zip codes to produce diverse and selective biological activities.

Megan L. Peach, J. Deschamps, N. Colburn, 2008, Journal of medicinal chemistry.

Down-regulation of ATM Protein Sensitizes Human Prostate Cancer Cells to Radiation-induced Apoptosis*

S. Leibel, N. Gueven, A. Haimovitz-Friedman, 2005, Journal of Biological Chemistry.

Gemcitabine kills proliferating endothelial cells exclusively via acid sphingomyelinase activation.

W. Tap, A. Haimovitz-Friedman, Z. Fuks, 2017, Cellular signalling.

An Antitumor Immune Response Is Evoked by Partial-Volume Single-Dose Radiation in 2 Murine Models.

J. Humm, J. Deasy, J. Wolchok, 2019, International journal of radiation oncology, biology, physics.

Organoids reveal that inherent radiosensitivity of small and large intestinal stem cells determines organ sensitivity.

J. Deasy, M. L. Martin, P. Paty, 2019, Cancer research.

Adenoviral Transduction of Human Acid Sphingomyelinase into Neo-Angiogenic Endothelium Radiosensitizes Tumor Cure

R. Weichselbaum, M. Sadelain, D. Harats, 2013, PloS one.

Kinase suppressor of Ras transphosphorylates c-Raf-1.

A. Haimovitz-Friedman, Z. Fuks, R. Kolesnick, 2009, Biochemical and biophysical research communications.

Protein kinase C mediates basic fibroblast growth factor protection of endothelial cells against radiation-induced apoptosis.

J. Michaeli, A. Haimovitz-Friedman, Z. Fuks, 1994, Cancer research.

Differential inhibition of radiation‐induced apoptosis

A. Haimovitz-Friedman, Z. Fuks, R. Kolesnick, 1997, Stem cells.

Correction: Endothelial Membrane Remodeling Is Obligate for Anti-Angiogenic Radiosensitization during Tumor Radiosurgery

M. Kaag, A. Haimovitz-Friedman, Z. Fuks, 2010, PloS one.

Endothelial Membrane Remodeling Is Obligate for Anti-Angiogenic Radiosensitization during Tumor Radiosurgery

M. Kaag, A. Haimovitz-Friedman, Z. Fuks, 2010, PloS one.

Axitinib sensitization of high Single Dose Radiotherapy.

S. Powell, A. Haimovitz-Friedman, Z. Fuks, 2014, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Niemann-Pick human lymphoblasts are resistant to phthalocyanine 4-photodynamic therapy-induced apoptosis.

D. Boothman, A. Haimovitz-Friedman, M. McLoughlin, 1999, Biochemical and biophysical research communications.

Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury

Evis Sala, Howard J. Halpern, Michael J. Zelefsky, 2019, The Journal of clinical investigation.

Radiation exposure of the base of the heart accelerates coronary atherosclerosis

F. Stewart, A. Haimovitz-Friedman, I. Kurland, 2021, bioRxiv.

An optical nanoreporter of endolysosomal lipid accumulation reveals enduring effects of diet on hepatic macrophages in vivo

Ming Zheng, Daniel S. Ory, Jeetain Mittal, 2018, Science Translational Medicine.

Transforming growth factor-beta 1 stimulates macrophage urokinase expression and release of matrix-bound basic fibroblast growth factor.

T. McCaffrey, A. Haimovitz-Friedman, M. García, 1993, Journal of cellular physiology.

Distinct Levels of Radioresistance in Lgr5+ Colonic Epithelial Stem Cells versus Lgr5+ Small Intestinal Stem Cells.

Z. Zeng, M. L. Martin, P. Paty, 2017, Cancer research.

Cell Autonomous Apoptosis Defects in Acid Sphingomyelinase Knockout Fibroblasts*

S. Menéndez, A. Haimovitz-Friedman, Z. Fuks, 2001, The Journal of Biological Chemistry.

Sphingolipids' role in radiotherapy for prostate cancer.

A. Haimovitz-Friedman, C. Hajj, 2013, Handbook of experimental pharmacology.

Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation

John Calvin Reed, A. Haimovitz-Friedman, Z. Fuks, 2011, PloS one.

Correction: Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation

John Calvin Reed, A. Haimovitz-Friedman, Z. Fuks, 2015, PLoS ONE.

Protein Kinase C Mediates Basic Fibroblast Growth Factor Protection of Endothelial Cells against Radiation-induced Apoptosis 1

J. Michaeli, A. Haimovitz-Friedman, Z. Fuks, 2006 .

Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis

A. Haimovitz-Friedman, Z. Fuks, R. Persaud, 1994, The Journal of experimental medicine.

Mitochondrial Ceramide-Rich Macrodomains Functionalize Bax upon Irradiation

John Calvin Reed, A. Haimovitz-Friedman, Z. Fuks, 2011, PloS one.

Radiation Damage in Endothelial Cells Autocrine Effects of Fibroblast Growth Factor in Repair of Updated

A. Haimovitz-Friedman, Z. Fuks, I. Vlodavsky, 2006 .

Spatially Fractionated Radiotherapy in the Era of Immunotherapy.

A. Haimovitz-Friedman, S. N. Powell, Atif J Khan, 2024, Seminars in radiation oncology.