C. Paraskeva

发表

Abrogation of the radiation-induced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell lines

L. Playle, D. Hicks, D. Qualtrough, 2002, British Journal of Cancer.

Inhibition of radiation-induced G2 delay potentiates cell death by apoptosis and/or the induction of giant cells in colorectal tumor cells with disrupted p53 function.

C. Paraskeva, T. Bracey, A. Williams, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Modulation of p53 expression in cultured colonic adenoma cell lines by the naturally occurring lumenal factors butyrate and deoxycholate

C. Paraskeva, A. Williams, D. Palmer, 1997, International journal of cancer.

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment.

Heather R. Roberts, Christos Paraskeva, A. C. Williams, 2009, Carcinogenesis.

A cyclooxygenase-2 (COX-2) selective non-steroidal anti-inflammatory drug enhances the growth inhibitory effect of butyrate in colorectal carcinoma cells expressing COX-2 protein: regulation of COX-2 by butyrate.

C. Paraskeva, T. Crew, D. Elder, 2000, Carcinogenesis.

Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia

A. C. Williams, C. Paraskeva, A. Kaidi, 2007, Nature Cell Biology.

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.

B. Vogelstein, J. Willson, S. Markowitz, 1990, Cancer research.

Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia.

A. C. Williams, C. Paraskeva, A. Kaidi, 2007, Nature cell biology.

Apoptosis is induced by the active metabolite of vitamin D3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: possible implications for prevention and therapy.

C. Paraskeva, L. Binderup, G. D. Díaz, 2000, Cancer research.

Nuclear BAG-1 expression inhibits apoptosis in colorectal adenoma-derived epithelial cells

G. Packham, C. Paraskeva, A. Williams, 2005, Apoptosis.

Hedgehog signalling in colorectal tumour cells: Induction of apoptosis with cyclopamine treatment

A. C. Williams, D. Qualtrough, C. Paraskeva, 2004, International journal of cancer.

Colon tumour cells increase PGE(2) by regulating COX-2 and 15-PGDH to promote survival during the microenvironmental stress of glucose deprivation.

Heather R. Roberts, A. C. Williams, C. Paraskeva, 2011, Carcinogenesis.

Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independence.

A. C. Williams, D. Qualtrough, C. Paraskeva, 2006, Cancer research.

The actin-bundling protein fascin is overexpressed in colorectal adenomas and promotes motility in adenoma cells in vitro

D. Qualtrough, C. Paraskeva, M. Pignatelli, 2009, British Journal of Cancer.

β-catenin negatively regulates expression of the prostaglandin transporter PGT in the normal intestinal epithelium and colorectal tumour cells: a role in the chemopreventive efficacy of aspirin?

J. Mariadason, C. Paraskeva, A. Williams, 2012, British Journal of Cancer.

Butyrate can act as a stimulator of growth or inducer of apoptosis in human colonic epithelial cell lines depending on the presence of alternative energy sources.

C. Paraskeva, A. Halestrap, B. Singh, 1997, Carcinogenesis.

Glycosylation patterns of mucins in colonic disease.

I. Brockhausen, C. Paraskeva, A. Corfield, 1995, Biochemical Society transactions.

Sodium butyrate induces apoptosis in human colonic tumour cell lines in a p53‐independent pathway: Implications for the possible role of dietary fibre in the prevention of large‐bowel cancer

A. Manning, C. Paraskeva, L. Huschtscha, 1993, International journal of cancer.

O-glycan inhibitors generate aryl-glycans, induce apoptosis and lead to growth inhibition in colorectal cancer cell lines.

T. Gallagher, C. Paraskeva, J. Michalski, 2009, Glycobiology.

Prostaglandin F2α stimulates motility and invasion in colorectal tumor cells

A. C. Williams, D. Qualtrough, C. Paraskeva, 2007 .

Induction of apoptosis by the 16-kDa amino-terminal fragment of the insulin-like growth factor binding protein 3 in human colonic carcinoma cells.

A. C. Williams, D. Hicks, C. Paraskeva, 2006, International journal of oncology.

The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2

D. Hicks, C. Paraskeva, A. Williams, 2005, Gut.

Butyrate downregulates α2β1 integrin: a possible role in the induction of apoptosis in colorectal cancer cell lines

D. Qualtrough, C. Paraskeva, A. Buda, 2003 .

Increased NF-κB DNA binding but not transcriptional activity during apoptosis induced by the COX-2-selective inhibitor NS-398 in colorectal carcinoma cells

D. Hicks, C. Paraskeva, H. Smartt, 2003, British Journal of Cancer.

Biosynthesis of mucin cell and organ culture methods for biosynthetic study.

C. Paraskeva, J. Dekker, A. Einerhand, 2000, Methods in molecular biology.

Therapy Carcinoma Cells : Possible Implications for Prevention and and Its Analogue EB 1089 in Colorectal Adenoma and 3 Apoptosis Is Induced by the Active Metabolite of Vitamin D Updated

C. Paraskeva, L. Binderup, G. D. Díaz, 2000 .

The use of cell and organ culture for the study of secreted mucins.

C. Paraskeva, A. Corfield, B. Singh, 1998, Methods in molecular biology.

Cell-cell contact and specific cytokines inhibit apoptosis of colonic epithelial cells: growth factors protect against c-myc-independent apoptosis.

D. Hicks, C. Paraskeva, T. Bracey, 1997, British Journal of Cancer.

Butyrate- but not TGFβ1-induced apoptosis of colorectal adenoma cells is associated with increased expression of the differentiation markers E-cadherin and alkaline phosphatase

C. Paraskeva, A. Butt, A. Hague, 1997, Cell Death and Differentiation.

Differential Growth Inhibition by the Aspirin Metabolite Salicylate in Human Colorectal Tumor Cell Lines: Enhanced Apoptosis in Carcinoma and in Vitro-transformed Adenoma Relative to Adenoma Cell Lines

D. Hicks, C. Paraskeva, D. Elder, 1996 .

Expression of carcinoembryonic antigen by adenoma and carcinoma derived epithelial cell lines: possible marker of tumour progression and modulation of expression by sodium butyrate.

C. Paraskeva, R. D. Berry, R. Berry, 1988, Carcinogenesis.

Immunodetection of cathepsins b and l present in and secreted from human pre‐malignant and malignant colorectal tumour cell lines

R. Maciewicz, C. Paraskeva, D. Etherington, 1989, International journal of cancer.

Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.

A. Manning, C. Paraskeva, A. Williams, 1991, Oncogene.

Colorectal cancer and dietary calcium intervention: a word of caution.

C. Paraskeva, 1992, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

Insulin-like growth factor binding protein 3 (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-kappaB.

C. Paraskeva, A. Williams, H. Smartt, 2007, Cell death and differentiation.

Inhibition of COX‐2 with NS‐398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: possibilities for combination therapy

D. Qualtrough, C. Paraskeva, D. Elder, 2007, Cell proliferation.

The cannabinoid delta(9)-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells.

A. C. Williams, C. Paraskeva, A. Greenhough, 2007, International journal of cancer.

BAG-1 suppresses expression of the key regulatory cytokine transforming growth factor beta [TGF-β1] in colorectal tumour cells

P. Townsend, A. C. Williams, C. Paraskeva, 2012, Oncogene.

Nutrient stress alters the glycosylation status of LGR5 resulting in reduced protein stability and membrane localisation in colorectal tumour cells: implications for targeting cancer stem cells

E. Molnár, C. Paraskeva, A. Williams, 2015, British Journal of Cancer.

Increased dosage and amplification of the focal adhesion kinase gene in human cancer cells

E. Parkinson, C. Paraskeva, V. Brunton, 1999, Oncogene.

The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the antiapoptotic function of BAG-1 protein in colorectal tumour cells: Rb increases nuclear localisation and function of BAG-1. Cell Death and Disease, 3, [e408].

P. Townsend, C. Paraskeva, A. Hague, 2012 .

The retinoblastoma protein (Rb) as an anti-apoptotic factor: expression of Rb is required for the anti-apoptotic function of BAG-1 protein in colorectal tumour cells

P. Townsend, C. Paraskeva, A. Williams, 2012, Cell Death and Disease.

Are different events involved in the development of sporadic versus hereditary tumours? The possible importance of the microenvironment in hereditary cancer.

C. Paraskeva, A. Williams, 1990, British Journal of Cancer.

O-glycan regulation of apoptosis and proliferation in colorectal cancer cell lines.

T. Gallagher, C. Paraskeva, A. Corfield, 2007, Biochemical Society transactions.

Circulating prostaglandins as biomarkers for colorectal cancer?

A. C. Williams, C. Paraskeva, A. Greenhough, 2015, EBioMedicine.

Differential growth response to oestrogen of premalignant and malignant colonic cell lines.

C. Paraskeva, M. Sheppard, P. Gallimore, 1994, Anticancer research.

BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activity.

A. C. Williams, G. Packham, C. Paraskeva, 2008, Carcinogenesis.

The MEK/ERK pathway mediates COX‐2‐selective NSAID‐induced apoptosis and induced COX‐2 protein expression in colorectal carcinoma cells

L. Playle, C. Paraskeva, D. Elder, 2002, International journal of cancer.

Butyrate acts as a survival factor for colonic epithelial cells: further fuel for the in vivo versus in vitro debate.

C. Paraskeva, A. Hague, B. Singh, 1997, Gastroenterology.

The protrusive phase and full development of integrin-dependent adhesions in colon epithelial cells require FAK- and ERK-mediated actin spike formation: deregulation in cancer cells.

S. Winder, C. Paraskeva, G. McLean, 2001, Neoplasia.

Mutant p53 is not fully dominant over endogenous wild type p53 in a colorectal adenoma cell line as demonstrated by induction of MDM2 protein and retention of a p53 dependent G1 arrest after gamma irradiation.

C. Paraskeva, T. Bracey, A. Williams, 1995, Oncogene.

Is the downregulation of EphB2 receptor expression during colorectal tumorigenesis due to hypoxia?

A. C. Williams, C. Paraskeva, M. Moorghen, 2007, Gut.

Human colorectal adenomas demonstrate a size‐dependent increase in epithelial cyclooxygenase‐2 expression

C. Paraskeva, D. Elder, N. Banu, 2002, The Journal of pathology.

Prospects in NSAID-derived chemoprevention of colorectal cancer.

D. Hicks, D. Qualtrough, C. Paraskeva, 2005, Biochemical Society transactions.

Cannabinoids and cancer: potential for colorectal cancer therapy.

D. Hicks, C. Paraskeva, A. Williams, 2005, Biochemical Society transactions.

Platelet glycoprotein IIIa Pl A polymorphism in young men with myocardial infarction

D. Hicks, C. Paraskeva, P. Hawkins, 1996 .

The adenomatous polyposis coli protein and retinoblastoma protein are cleaved early in apoptosis and are potential substrates for caspases

G. Cohen, C. Paraskeva, M. MacFarlane, 1998, Cell Death and Differentiation.

Adenovirus type 12-transformed rat embryo brain and rat liver epithelial cell lines: adenovirus type 12 genome content and viral protein expression

C. Paraskeva, A. Dunn, P. Gallimore, 1982, Journal of virology.

COX-2 inhibitors for colorectal cancer

C. Paraskeva, D. Elder, 1998, Nature Medicine.

Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin D

R. Maciewicz, A. C. Williams, C. Paraskeva, 1996, International journal of cancer.

A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer

B. Ozanne, C. Paraskeva, V. Brunton, 1997, Oncogene.

Possible involvement of chromosome 1 in in vitro immortalization: Evidence from progression of a human adenoma‐derived cell line in vitro

C. Paraskeva, S. Finerty, S. Powell, 1989, International journal of cancer.

Multiple Steps in the in vitro Immortalisation and Neoplastic Conversion of Human Colonic Epithelial Cells

A. C. Williams, C. Paraskeva, Manning Am, 1991 .

Characterization of a sialic‐acid‐rich mucus glycoprotein secreted by a premalignant human colorectal adenoma cell line

C. Paraskeva, A. Corfield, J. Clamp, 1990, International journal of cancer.

The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells.

A. C. Williams, D. Hicks, C. Paraskeva, 2010, International journal of oncology.

The catalytic activity of the Src family kinases is required to disrupt cadherin-dependent cell-cell contacts.

E. Parkinson, C. Paraskeva, G. McLean, 2000, Molecular biology of the cell.

Heparan Sulfate Undergoes Specific Structural Changes during the Progression from Human Colon Adenoma to Carcinoma in Vitro *

G. Jayson, C. Paraskeva, J. Turnbull, 1998, The Journal of Biological Chemistry.

Promotability and tissue specificity of hereditary cancer genes: Do hereditary cancer patients have a reduced requirement for tumor promotion because all their somatic cells are heterozygous at the predisposing locus?

A. C. Williams, C. Paraskeva, A. Williams, 1992, Molecular carcinogenesis.

Molecular events including p53 and k-ras alterations in the in vitro progression of a human colorectal adenoma cell line to an adenocarcinoma.

D. Lane, C. Marshall, C. Paraskeva, 1993, Oncogene.

Apoptosis induction and cyclooxygenase‐2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase‐2‐selective non‐steroidal anti‐inflammatory drug NS‐398

C. Paraskeva, T. Crew, D. Elder, 2000, International journal of cancer.

Prostaglandin F(2alpha) stimulates motility and invasion in colorectal tumor cells.

A. C. Williams, D. Qualtrough, C. Paraskeva, 2007, International journal of cancer.

Action of a library of O-glycosylation inhibitors on the growth of human colorectal cancer cells in culture.

T. Gallagher, C. Paraskeva, A. Corfield, 2005, Biochemical Society transactions.

Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression.

C. Paraskeva, D. Elder, A. Hague, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Corrigendum to “Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer” [Biochim. Biophys. Acta 1766 (2006) 104–119]

A. C. Williams, C. Paraskeva, A. Kaidi, 2007 .

Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer.

A. C. Williams, C. Paraskeva, A. Kaidi, 2006, Biochimica et biophysica acta.

The short-chain fatty acid butyrate induces apoptosis in colorectal tumour cell lines.

C. Paraskeva, A. Hague, 1995, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

O-glycan biosynthesis in human colorectal adenoma cells during progression to cancer.

I. Brockhausen, C. Paraskeva, J. Yang, 1994, European journal of biochemistry.

Neoplastic transformation of a human colonic epithelial cell line: in vitro evidence for the adenoma to carcinoma sequence.

C. Paraskeva, A. Williams, S. Harper, 1990, Cancer research.

Reduction of sialic acid O-acetylation in human colonic mucins in the adenoma-carcinoma sequence

B. Warren, C. Paraskeva, A. Corfield, 1999, Glycoconjugate Journal.

Tumorigenicity and in vitro characteristics of rat liver epithelial cells and their adenovirus‐transformed derivatives

C. Paraskeva, P. Gallimore, 1980, International journal of cancer.

Sensitivity of normal and transformed rat liver epithelial cells to benzo[a]pyrene toxicity.

E. Parkinson, C. Paraskeva, 1981, Carcinogenesis.

Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer

K. Kinzler, B. Vogelstein, E. Stanbridge, 1992, Molecular and cellular biology.

In vitro culture of human foetal colonic epithelial cells and their transformation with origin minus SV40 DNA.

C. Paraskeva, R. D. Berry, S. Powell, 1988, British Journal of Cancer.

Biosynthesis of the MUC2 mucin: evidence for a slow assembly of fully glycosylated units.

C. Paraskeva, D. Thornton, J. Sheehan, 1996, The Biochemical journal.

A study of the intracellular and secreted forms of the MUC2 mucin from the PC/AA intestinal cell line.

C. Paraskeva, D. Thornton, J. Sheehan, 1999, Glycobiology.

Human Adenovirus Type 2 but Not Adenovirus Type 12 Is Mutagenic at the Hypoxanthine Phosphoribosyltransferase Locus of Cloned Rat Liver Epithelial Cells

C. Paraskeva, P. Gallimore, P. Biggs, 1983, Journal of virology.

The proapoptotic BH3-only protein Bim is downregulated in a subset of colorectal cancers and is repressed by antiapoptotic COX-2/PGE2 signalling in colorectal adenoma cells

D. Hicks, C. Paraskeva, A. Greenhough, 2010, Oncogene.

DMBT1 expression and glycosylation during the adenoma-carcinoma sequence in colorectal cancer.

C. Paraskeva, J. Michalski, A. Corfield, 2005, Biochemical Society transactions.

The isolation and characterization of colorectal epithelial cell lines at different stages in malignant transformation from familial polyposis coli patients

D. Sheer, C. Paraskeva, C. Wigley, 1984, International journal of cancer.

LGR5 promotes survival in human colorectal adenoma cells and is upregulated by PGE2: implications for targeting adenoma stem cells with NSAIDs.

C. Paraskeva, A. Greenhough, H. Smartt, 2013, Carcinogenesis.

The APC gene product in normal and tumor cells.

K. Kinzler, B. Vogelstein, J. Willson, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Autolysosomal β‐catenin degradation regulates Wnt‐autophagy‐p62 crosstalk

C. Paraskeva, P. Ordóñez-Morán, A. Greenhough, 2012, The EMBO journal.

Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways

C. Andersen, C. Paraskeva, K. Thorsen, 2012, Oncogene.

Differential expression proteomics of human colorectal cancer based on a syngeneic cellular model for the progression of adenoma to carcinoma

S. Baldus, C. Paraskeva, S. Müller, 2010, Proteomics.

Advances in Brief p 53 Gene Mutations Occur in Combination with 17 p Allelic Deletions as Late Events in Colorectal Tumorigenesis 1

B. Vogelstein, J. Willson, S. Markowitz, 2006 .

Escape from negative regulation of growth by transforming growth factor β and from the induction of apoptosis by the dietary agent sodium butyrate may be important in colorectal carcinogenesis

A. Manning, C. Paraskeva, A. Hague, 1993, Cancer and Metastasis Reviews.

Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system

E. Fearon, D. Qualtrough, C. Paraskeva, 2002, Gut.

A study of ras gene mutations in colonic adenomas from familial polyposis coli patients.

C. Marshall, N. Wright, C. Paraskeva, 1988, Oncogene.

Specific cytogenetic abnormalities and k‐ras mutation in two new human colorectal‐adenoma‐derived cell lines

C. Marshall, C. Paraskeva, R. Mountford, 1992, International journal of cancer.

BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis

N. Perkins, P. Townsend, C. Paraskeva, 2011, Oncogene.

The Hedgehog Inhibitor Cyclopamine Reduces β-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells

D. Qualtrough, C. Paraskeva, B. Speight, 2015, Cancers.

Insulin-like growth factor binding protein 3 (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-κB

C. Paraskeva, A. Williams, H. Smartt, 2007, Cell Death and Differentiation.

An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis

C. Paraskeva, A. Williams, T. Collard, 1999, Oncogene.

Epigenetic silencing of the intronic microRNA hsa-miR-342 and its host gene EVL in colorectal cancer

M. Washington, B. Fritz, R. Parkin, 2008, Oncogene.

TGF-β1 signalling, connecting aberrant inflammation and colorectal tumorigenesis.

C. Paraskeva, I. Paterson, Victoria R. Skeen, 2012, Current pharmaceutical design.

miR-153 supports colorectal cancer progression via pleiotropic effects that enhance invasion and chemotherapeutic resistance.

G. Packham, C. Paraskeva, M. Bullock, 2013, Cancer research.

BCL-3 promotes a cancer stem cell phenotype by enhancing β-catenin signalling in colorectal tumour cells

C. Paraskeva, A. Greenhough, R. Clarkson, 2019, Disease Models & Mechanisms.

BCL-3 enhances β-catenin signalling in colorectal tumour cells promoting a cancer stem cell phenotype

C. Paraskeva, A. Greenhough, R. Clarkson, 2017, bioRxiv.

BCL-3 expression promotes colorectal tumorigenesis through activation of AKT signalling

R. Poulsom, C. Paraskeva, A. Greenhough, 2015, Gut.

bcl‐2 and bak may play a pivotal role in sodium butyrate‐induced apoptosis in colonic epithelial cells; however overexpression of bcl‐2 does not protect against bak‐mediated apoptosis

John Calvin Reed, S. Krajewski, D. Hicks, 1997, International journal of cancer.

Specific cytogenetic abnormalities in two new human colorectal adenoma-derived epithelial cell lines.

C. Paraskeva, R. Mountford, S. Powell, 1989, Cancer research.

Transcriptional down-regulation of the retinoblastoma protein is associated with differentiation and apoptosis in human colorectal epithelial cells

C. Paraskeva, J. Bond, A. Williams, 2001, British Journal of Cancer.

Apoptosis in colorectal tumour cells: Induction by the short chain fatty acids butyrate, propionate and acetate and by the bile salt deoxycholate

D. Hicks, C. Paraskeva, D. Elder, 1995, International journal of cancer.

BCL-2 expression in human colorectal adenomas and carcinomas.

D. Hicks, C. Paraskeva, M. Moorghen, 1994, Oncogene.

The cannabinoid D 9-tetrahydrocannabinol inhibits RAS-MAPK and PI 3 K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells

C. Paraskeva, A. Greenhough, H. Patsos, 2015 .

The cannabinoid δ9‐tetrahydrocannabinol inhibits RAS‐MAPK and PI3K‐AKT survival signalling and induces BAD‐mediated apoptosis in colorectal cancer cells

C. Paraskeva, A. Greenhough, H. Patsos, 2007 .

The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival.

G. Packham, C. Paraskeva, A. Williams, 2005, Biochemical Society transactions.

The retinoblastoma protein interacts with Bag‐1 in human colonic adenoma and carcinoma derived cell lines

P. Townsend, G. Packham, C. Paraskeva, 2003, International journal of cancer.

The role of butyrate in human colonic epithelial cells: an energy source or inducer of differentiation and apoptosis?

C. Paraskeva, A. Butt, A. Hague, 1996, Proceedings of the Nutrition Society.

Decreased levels of p26-Bcl-2, but not p30 phosphorylated Bcl-2, precede TGFbeta1-induced apoptosis in colorectal adenoma cells.

John Calvin Reed, D. Hicks, C. Paraskeva, 1998, Carcinogenesis.

Mini review: In vitro models of colorectal carcinogenesis and the possible role of APC and Rb cleavage, and Bcl‐2 in apoptosis

C. Paraskeva, A. Butty, A. Hague, 1995 .

Loss of apc protein expressed by human colonic epithelial cells and the appearance of a specific low‐molecular‐weight form is associated with apoptosis IN vitro

C. Paraskeva, A. Butt, A. Hague, 1994, International journal of cancer.

β-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells

Heather R. Roberts, J. Mariadason, C. Paraskeva, 2011, Gut.

Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia.

D. Qualtrough, C. Paraskeva, A. Kaidi, 2006, Cancer research.

Molecular Medicine Hypoxic cell survival via HIF-GPRC 5 A-YAP

O. Sansom, Paul Martin, C. Paraskeva, 2018 .

HGF/Met signalling promotes PGE(2) biogenesis via regulation of COX-2 and 15-PGDH expression in colorectal cancer cells.

Heather R. Roberts, D. Hicks, C. Paraskeva, 2009, Carcinogenesis.

Butyrate downregulates alpha2beta1 integrin: a possible role in the induction of apoptosis in colorectal cancer cell lines.

D. Qualtrough, C. Paraskeva, A. Buda, 2003, Gut.

Transcriptional upregulation of the insulin-like growth factor binding protein IGFBP-3 by sodium butyrate increases IGF-independent apoptosis in human colonic adenoma-derived epithelial cells.

C. Paraskeva, A. Williams, A. Butt, 2003, Carcinogenesis.

BCL‑3 promotes cyclooxygenase‑2/prostaglandin E2 signalling in colorectal cancer.

C. Paraskeva, A. Greenhough, H. M. Fallatah, 2020, International journal of oncology.

Apoptosis and disease: a matter of cell fate

C. Paraskeva, A. Hague, 2004, Cell Death and Differentiation.

Comparative analysis of PCR-based biomarker assay methods for colorectal polyp detection from fecal DNA.

M. Washington, K. Tsuchiya, C. Paraskeva, 2009, Clinical chemistry.

Differential expression proteomics of human colorectal cancer based on a syngeneic cellular model for the progression of adenoma to carcinoma

S. Baldus, C. Paraskeva, S. Müller, 2010 .

Increased p53-dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells.

C. Paraskeva, A. Williams, P. Newcomb, 2000, Cancer research.

A study to determine the reasons for differences in the tumorigenicity of rat cell lines transformed by adenovirus 2 and adenovirus 12.

C. Paraskeva, P. Gallimore, 1980, Cold Spring Harbor symposia on quantitative biology.

Adenovirus-cell interactions early after infection: in vitro characteristics and tumourigenicity of adenovirus type 2-transformed rat liver epithelial cells.

C. Paraskeva, P. Gallimore, K. Brown, 1982, The Journal of general virology.

In vitro models for studying colorectal carcinogenesis: cellular and molecular events including APC and Rb cleavage in the control of proliferation, differentiation and apoptosis.

C. Paraskeva, A. Williams, D. Elder, 1996, Biochimica et biophysica acta.

VEGF165b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy

S. Harper, D. Bates, C. Paraskeva, 2008, British Journal of Cancer.

Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal carcinogenesis

M MacFarlane, G M Cohen, G. Cohen, 2005, British Journal of Cancer.

Mucin biosynthesis and macromolecular assembly.

C. Paraskeva, C. Hanski, D. Thornton, 1995, Biochemical Society transactions.

Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma relative to adenoma cell lines.

D. Hicks, C. Paraskeva, D. Elder, 1996, Cancer research.

Colorectal cancer prognosis: is it all mutation, mutation, mutation?

C. Paraskeva, A. B. Hassan, A. Hassan, 2005, Gut.

Cancer cell adaptation to hypoxia involves a HIF‐GPRC5A‐YAP axis

O. Sansom, Paul Martin, C. Paraskeva, 2018, EMBO molecular medicine.

In vitro models of human colorectal cancer.

A. Manning, C. Paraskeva, A. Williams, 1993, Cancer Surveys.

Gamma-radiation-induced apoptosis in human colorectal adenoma and carcinoma cell lines can occur in the absence of wild type p53.

C. Paraskeva, T. Bracey, A. Preece, 1995, Oncogene.

The effect of different TP53 mutations on the chromosomal stability of a human colonic adenoma derived cell line with endogenous wild type TP53 activity, before and after DNA damage

C. Paraskeva, R. Newbold, T. Collard, 1997, Genes, chromosomes & cancer.

Increased p 53-dependent Apoptosis by the Insulin-like Growth Factor Binding Protein IGFBP-3 in Human Colonic Adenoma-derived Cells 1

C. Paraskeva, P. Newcomb, J. Holly, 2000 .

NSAIDs to prevent colorectal cancer: a question of sensitivity.

C. Paraskeva, D. Elder, 1997, Gastroenterology.

Progression of familial adenomatous polyposis (FAP) colonic cells after transfer of the src or polyoma middle T oncogenes: cooperation between src and HGF/Met in invasion.

M. Mareel, F. van Roy, P. Comoglio, 1997, British Journal of Cancer.

Coordinated modulation of the fibroblast growth factor dual receptor mechanism during transformation from human colon adenoma to carcinoma

G. Jayson, C. Paraskeva, K. Schofield, 1999, International journal of cancer.

Correlation of cellular differentiation in human colorectal carcinoma and adenoma cell lines with metabolite profiles determined by 1H magnetic resonance spectroscopy

W. Mackinnon, C. Mountford, C. Paraskeva, 1994, International journal of cancer.

A single human colonic adenoma cell line can be converted IN VITRO to both A colorectal adenocarcinoma and A mucinous carcinoma

C. Paraskeva, A. Corfield, A. Hague, 1992, International journal of cancer.

Colorectal carcinogenesis: sequential steps in the in vitro immortalization and transformation of human colonic epithelial cells (review).

C. Paraskeva, A. Williams, A. Corfield, 1990, Anticancer research.

Are aspirin and other non-steroidal anti-inflammatory drugs effective in the prevention and treatment of colorectal cancer?

C. Paraskeva, D. Elder, 1996, The Lancet.

Induced apoptosis in the prevention of colorectal cancer by non-steroidal anti-inflammatory drugs

C. Paraskeva, D. Elder, 1999, Apoptosis.

LOSS OF APC PROTEIN EXPRESSED BY HUMAN COLONIC EPITHELIAL CELLS AND THE APPEARANCE OF A SPECIFIC WITH APOPTOSIS IN VITRO LOW-MOLECULAR-WEIGHT FORM IS ASSOCIATED

C. Paraskeva, A. Hague, A. Williams, 2006 .

Biological consequences of the genetic changes which occur during human colorectal carcinogenesis.

A. Manning, C. Paraskeva, A. Williams, 1993, Seminars in cancer biology.

Cellular and Molecular Events Involved in Tumour Progression in Colorectal Carcinogenesis: A Study of the Adenoma Carcinoma Sequence In Vitro

C. Paraskeva, S. Finerty, S. Harper, 1990 .

S. Harper, D. Bates, C. Paraskeva, 2008, British Journal of Cancer.

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment.

Heather R. Roberts, C. Paraskeva, A. Greenhough, 2009, Carcinogenesis.

Colorectal cancer prognosis: is it all mutation, mutation, mutation?

C. Paraskeva, A. Hassan, 2005, Gut.

BAG-1 is up-regulated in colorectal tumour progression and promotes colorectal tumour cell survival through increased NF-kappaB activity.

G. Packham, C. Paraskeva, A. Hague, 2008, Carcinogenesis.