B. Copple

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Oligonucleotide Enhanced Cytotoxicity of Idarubicin for Lymphoma Cells

T. Greiner, J. Vose, P. Iversen, 2001, Leukemia & lymphoma.

Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies.

T. Greiner, P. Iversen, G. Zon, 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Pharmacology and toxicology of phosphorothioate oligonucleotides in the mouse, rat, monkey and man.

P. Iversen, B. Copple, H. K. Tewary, 1995, Toxicology letters.

Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo.

H. Chung, Yung-Hyun Choi, B. Copple, 2012, International journal of oncology.

Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice.

Hartmut Jaeschke, H. Jaeschke, A. Ramachandran, 2014, Toxicology letters.

Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia‐inducible factor and transforming growth factor‐β‐dependent mechanisms

B. Copple, 2010, Liver international : official journal of the International Association for the Study of the Liver.

Regulation of macrophage activation in the liver after acute injury: Role of the fibrinolytic system

B. Copple, Jenna D Strickland, K. Roth, 2020, World journal of gastroenterology.

Modulation of macrophage phenotype to treat liver fibrosis-Current approaches and future possibilities.

B. Copple, Jenna D Strickland, 2021, Advances in pharmacology.

Role of Hypoxia-Inducible Factors in the Development of Liver Fibrosis

B. Copple, K. Roth, 2015, Cellular and molecular gastroenterology and hepatology.

Interleukin-6 Drives Key Pathologic Outcomes in Experimental Acetaminophen-induced Liver Failure

A. Dorrance, B. Bhushan, U. Apte, 2021, bioRxiv.

Dichotomous Role of Plasmin in Regulation of Macrophage Function after Acetaminophen Overdose.

T. Billiar, B. Copple, J. Luyendyk, 2019, The American journal of pathology.

The Transition from Fatty Liver to NASH Associates with SAMe Depletion in db/db Mice Fed a Methionine Choline-Deficient Diet

B. Copple, M. Wortham, M. Gyamfi, 2008, Digestive Diseases and Sciences.

Oxidative Stress and the Pathogenesis of Cholestasis

H. Jaeschke, B. Copple, C. Klaassen, 2010, Seminars in liver disease.

Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis.

H. Jaeschke, B. Copple, Katryn Allen, 2011, The American journal of pathology.

Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease.

B. Copple, J. Luyendyk, Karen M. Kassel, 2012, The American journal of pathology.

Basement membrane and matrix metalloproteinases in monocrotaline-induced liver injury.

M. Shibuya, B. Copple, P. Ganey, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Hypoxia‐inducible factor‐1α regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis

L. Burgoon, B. Copple, J. Moon, 2011, Liver international : official journal of the International Association for the Study of the Liver.

Hypoxia Stimulates Hepatocyte Epithelial to Mesenchymal Transition

B. Copple, B. Sullivan, S. Bai, 2010 .

Modulating Macrophage Phenotype in Mice Dependent Manner by - a Factor-1of Necrotic Cells in a Hypoxia-Inducible Hepatic Stellate Cells Orchestrate Clearance

Ryan, B. Copple, J. Luyendyk, 2014 .

Hepatic Stellate Cells Orchestrate Clearance of Necrotic Cells in a Hypoxia-Inducible Factor-1α–Dependent Manner by Modulating Macrophage Phenotype in Mice

B. Copple, J. Luyendyk, A. Pace, 2014, The Journal of Immunology.

This information is current as Modulating Macrophage Phenotype in Mice Dependent Manner by − α Factor-1 of Necrotic Cells in a Hypoxia-Inducible Hepatic Stellate Cells Orchestrate Clearance

B. Copple, J. Luyendyk, A. Pace, 2014 .

Hypoxia‐inducible factor‐dependent production of profibrotic mediators by hypoxic Kupffer cells

B. Copple, J. Moon, S. Bai, 2009, Hepatology research : the official journal of the Japan Society of Hepatology.

Modes of cell death in rat liver after monocrotaline exposure.

C. Rondelli, B. Copple, P. Ganey, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

Thrombin and Protease-Activated Receptor-1 Agonists Promote Lipopolysaccharide-Induced Hepatocellular Injury in Perfused Livers

B. Copple, P. Ganey, R. Roth, 2003, Journal of Pharmacology and Experimental Therapeutics.

Effect of bile duct ligation on bile acid composition in mouse serum and liver

H. Jaeschke, B. Copple, Ji-Young Hong, 2012, Liver international : official journal of the International Association for the Study of the Liver.

Early growth response factor-1 is critical for cholestatic liver injury.

B. Copple, N. Kim, A. Slitt, 2006, Toxicological sciences : an official journal of the Society of Toxicology.

Anticoagulants prevent monocrotaline-induced hepatic parenchymal cell injury but not endothelial cell injury in the rat.

B. Copple, P. Ganey, R. Roth, 2002, Toxicology and applied pharmacology.

Liver inflammation during monocrotaline hepatotoxicity.

B. Copple, P. Ganey, R. Roth, 2003, Toxicology.

Reduced Liver Fibrosis in Hypoxia-inducible Factor-1α-deficient Mice

B. Copple, F. Gonzalez, J. Moon, 2022 .

The Role of Hypoxia-Inducible Factor-1 (cid:1) in Acetaminophen Hepatotoxicity

B. Copple, J. Luyendyk, P. Ganey, 2011 .

Upregulation of early growth response factor-1 by bile acids requires mitogen-activated protein kinase signaling.

B. Copple, N. Kim, J. Moon, 2010, Toxicology and applied pharmacology.

Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy.

H. Jaeschke, B. Copple, J. Luyendyk, 2014, Journal of hepatology.

THE TEMPORAL RELATIONSHIP BETWEEN BACTERIAL LIPOPOLYSACCHARIDE AND MONOCROTALINE EXPOSURES INFLUENCES TOXICITY: SHIFT IN RESPONSE FROM HEPATOTOXICITY TO NITRIC OXIDE-DEPENDENT LETHALITY

B. Copple, P. Ganey, R. Roth, 2002, Journal of toxicology and environmental health. Part A.

Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure.

B. Copple, P. Ganey, R. Roth, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Gene profiling of maternal hepatic adaptations to pregnancy

B. Copple, J. Bustamante, G. Dai, 2010, Liver international : official journal of the International Association for the Study of the Liver.

IL-17A synergistically enhances bile acid-induced inflammation during obstructive cholestasis.

B. Copple, J. Luyendyk, C. Rockwell, 2013, The American journal of pathology.

2.16 – Mechanisms of Liver Fibrosis☆

B. Copple, K. Roth, 2018 .

Phenotypic Changes in Hepatic Stellate Cells in Response to Toxic Liver Injury

B. Copple, 2014, Current Pathobiology Reports.

Hepatic and extrahepatic factors critical for liver injury during lipopolysaccharide exposure.

B. Copple, P. Ganey, R. Roth, 2001, American journal of physiology. Gastrointestinal and liver physiology.

E2F1 is a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr‐1/SHP/EID1 network

B. Copple, G. Guo, B. Kong, 2014, Hepatology.

Role of Hypoxia Inducing Factor-1β in Alcohol-Induced Autophagy, Steatosis and Liver Injury in Mice

B. Copple, W. Ding, Heqing Huang, 2014, PloS one.

GASTROINTESTINAL , HEPATOBILIARY , AND PANCREATIC PATHOLOGY IL-17 A Synergistically Enhances Bile Acid e Induced In fl ammation during Obstructive Cholestasis

Brien, B. Copple, J. Luyendyk, 2013 .

Aspirin induces apoptosis in vitro and inhibits tumor growth of human hepatocellular carcinoma cells in a nude mouse xenograft model

H. Chung, Yung-Hyun Choi, B. Copple, 2011, International journal of oncology.

Differential Sensitivity of Kupffer Cells and Hepatic Monocyte-Derived Macrophages to Bacterial Lipopolysaccharide

B. Copple, K. Roth, C. Rockwell, 2019, Clinical & experimental gastroenterology & hepatology.

Tissue factor-dependent coagulation contributes to alpha-naphthylisothiocyanate-induced cholestatic liver injury in mice.

B. Copple, D. Kirchhofer, J. Luyendyk, 2009, American journal of physiology. Gastrointestinal and liver physiology.

Hypoxia upregulates Cxcl12 in hepatocytes by a complex mechanism involving hypoxia-inducible factors and transforming growth factor-β.

B. Copple, Jenna D Strickland, Domonique Garrison, 2020, Cytokine.

Anticoagulation and inhibition of nitric oxide synthase influence hepatic hypoxia after monocrotaline exposure.

B. Copple, P. Ganey, R. Roth, 2006, Toxicology.

Differential regulation of hepatic physiology and injury by the TAM receptors Axl and Mer

B. Copple, P. Través, G. Lemke, 2020, Life Science Alliance.

Differential TAM receptor regulation of hepatic physiology and injury

B. Copple, P. Través, G. Lemke, 2020, bioRxiv.

Gastrointestinal , Hepatobiliary , and Pancreatic Pathology Fibrinogen Deficiency Increases Liver Injury and Early Growth Response-1 ( Egr-1 ) Expression in a Model of Chronic Xenobiotic-Induced Cholestasis

B. Copple, J. Luyendyk, Karen M. Kassel, 2011 .

Differential Roles of Unsaturated and Saturated Fatty Acids on Autophagy and Apoptosis in Hepatocytes

B. Copple, J. Luyendyk, W. Ding, 2011, Journal of Pharmacology and Experimental Therapeutics.

Continuous infusion of antisense phosphorothioate therapeutics.

P. Iversen, M. Bishop, B. Copple, 1996, Methods in molecular medicine.

Endothelial cell injury and coagulation system activation during synergistic hepatotoxicity from monocrotaline and bacterial lipopolysaccharide coexposure.

M. Shibuya, B. Copple, P. Ganey, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

The Role of Hypoxia-Inducible Factor-1α in Acetaminophen Hepatotoxicity

B. Copple, J. Luyendyk, P. Ganey, 2011, Journal of Pharmacology and Experimental Therapeutics.

Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice.

B. Copple, F. Gonzalez, J. Moon, 2009, American journal of physiology. Gastrointestinal and liver physiology.

Enhancement of allyl alcohol hepatotoxicity by endotoxin requires extrahepatic factors.

B. Copple, P. Ganey, R. Roth, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Hypoxia-Inducible Factor Activation in Myeloid Cells Contributes to the Development of Liver Fibrosis in Cholestatic Mice

B. Copple, S. Kaska, Callie J Wentling, 2012, Journal of Pharmacology and Experimental Therapeutics.

Electron microscopy in small cell lung carcinomas: clinical correlation.

F. Moatamed, B. Copple, S. Wright, 1984, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules.

B. Copple, Tiangang Li, 2016, Pharmacological research.

Mechanisms of Liver Fibrosis

B. Copple, T. Welch, K. Allen, 2010 .

Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis in mice.

B. Copple, J. Luyendyk, B. Sullivan, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Hepatic ZIP8 deficiency is associated with disrupted selenium homeostasis, liver pathology, and tumor formation.

D. Nebert, B. Copple, Hua Wang, 2018, American journal of physiology. Gastrointestinal and liver physiology.

Hypoxia‐inducible factor‐dependent production of profibrotic mediators by hypoxic hepatocytes

B. Copple, N. Kim, J. Moon, 2008, Liver international : official journal of the International Association for the Study of the Liver.

Liver fibrosis is driven by protease‐activated receptor‐1 expressed by hepatic stellate cells in experimental chronic liver injury

B. Copple, J. Luyendyk, K. Williams, 2020, Research and practice in thrombosis and haemostasis.

Augmentation of aflatoxin B1 hepatotoxicity by endotoxin: involvement of endothelium and the coagulation system.

B. Copple, J. Luyendyk, P. Ganey, 2003, Toxicological sciences : an official journal of the Society of Toxicology.

AUTOIMMUNE, CHOLESTATIC AND BILIARY DISEASE E2F1 Is a Novel Fibrogenic Gene That Regulates Cholestatic Liver Fibrosis Through the Egr-1/SHP/EID1 Network

B. Copple, G. Guo, B. Kong, 2014 .

Coagulation‐driven platelet activation reduces cholestatic liver injury and fibrosis in mice

B. Copple, J. Luyendyk, A. Kopec, 2015, Journal of thrombosis and haemostasis : JTH.

Reaction between metabolically activated acetaminophen and phosphorothioate oligonucleotides.

P. Iversen, B. Copple, W. Gmeiner, 1995, Toxicology and Applied Pharmacology.

Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defective hepatic autophagy.

H. Jaeschke, B. Copple, J. Luyendyk, 2014, Journal of hepatology.

Reduced liver fibrosis in hypoxia-inducible factor-1alpha-deficient mice.

B. Copple, F. Gonzalez, J. Moon, 2009, American journal of physiology. Gastrointestinal and liver physiology.

E2F1 is a novel fibrogenic gene that regulates cholestatic liver fibrosis through the Egr‐1/SHP/EID1 network

B. Copple, B. Kong, Jun Xu, 2014, Hepatology.

Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease.

B. Copple, J. Luyendyk, Karen M. Kassel, 2012, The American journal of pathology.

Hypoxia‐inducible factor‐1α regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis

L. Burgoon, B. Copple, J. Moon, 2011, Liver international : official journal of the International Association for the Study of the Liver.

Good cells go bad: immune dysregulation in the transition from acute liver injury to liver failure after acetaminophen overdose.

B. Copple, J. Luyendyk, Elena Morozova, 2023, Drug metabolism and disposition: the biological fate of chemicals.

Interleukin-10 disrupts liver repair in acetaminophen-induced acute liver failure

B. Copple, J. Luyendyk, K. Roth, 2023, Frontiers in immunology.