J. Isaacs

发表

Requirement for HDM2 Activity in the Rapid Degradation of p53 in Neuroblastoma*

L. Neckers, J. Isaacs, S. Saito, 2001, The Journal of Biological Chemistry.

Differential subcellular p53 localization and function in N- and S-type neuroblastoma cell lines.

J. Barrett, B. Weissman, J. Isaacs, 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

p53-dependent p21 induction following gamma-irradiation without concomitant p53 induction in a human peripheral neuroepithelioma cell line.

J. Selkirk, J. Barrett, B. Weissman, 1997, Cancer research.

Hsp90 Is an Essential Regulator of EphA2 Receptor Stability and Signaling: Implications for Cancer Cell Migration and Metastasis

J. Isaacs, Xueguang Liu, B. Annamalai, 2009, Molecular Cancer Research.

Genetic Basis of Cancer of the Kidney

W. Marston Linehan, Peter Choyke, Maria Merino, 2004, Clinical Cancer Research.

IL‐1β mediated up‐regulation of HIF‐lα via an NFkB/COX‐2 pathway identifies HIF‐1 as a critical link between inflammation and oncogenesis

L. Neckers, J. Isaacs, J. Trepel, 2003 .

Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor κ B activation

L. Neckers, Zheng‐gang Liu, J. Isaacs, 2022 .

Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation.

L. Neckers, Zheng‐gang Liu, J. Isaacs, 2003, The Biochemical journal.

Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation

M. Hance, J. Isaacs, Shane B Wing, 2011, BMC Cancer.

Interactions between Hsp90 and oncogenic viruses: implications for viral cancer therapeutics.

J. Isaacs, Z. Qin, L. Dai, 2011, American journal of cancer research.

Aryl Hydrocarbon Nuclear Translocator (ARNT) Promotes Oxygen-independent Stabilization of Hypoxia-inducible Factor-1α by Modulating an Hsp90-dependent Regulatory Pathway*

L. Neckers, J. Isaacs, Yun-jin Jung, 2004, Journal of Biological Chemistry.

BRCA1 Plays a Role in the Hypoxic Response by Regulating HIF-1α Stability and by Modulating Vascular Endothelial Growth Factor Expression*

J. Isaacs, C. Cho, Jeong-Keun Rih, 2006, Journal of Biological Chemistry.

Two posttranscriptional pathways that regulate p21(Cip1/Waf1/Sdi1) are identified by HPV16-E6 interaction and correlate with life span and cellular senescence.

J. Barrett, D. Alcorta, J. Isaacs, 1999, Experimental cell research.

Interference of proteins involved in the cytoplasmic sequestration of p53 with human papillomavirus E6–mediated degradation

J. Barrett, B. Weissman, J. Isaacs, 1999, Molecular carcinogenesis.

Extracellular Hsp90 serves as a co-factor for NF-κB activation and cellular pathogenesis induced by an oncogenic herpesvirus.

J. Isaacs, B. Toole, Z. Qin, 2011, American journal of cancer research.

Heat shock protein 90 as a molecular target for cancer therapeutics.

L. Neckers, J. Isaacs, Len Neckers, 2003, Cancer cell.

Failure of HPV E6 to rapidly degrade p53 in human HeLa×PNET cell hybrids

J. Barrett, B. Weissman, M. Hansen, 1997, Oncogene.

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability.

Yuen-Li Chung, W Marston Linehan, W. Linehan, 2005, Cancer cell.

Secreted Hsp90 Is a Novel Regulator of the Epithelial to Mesenchymal Transition (EMT) in Prostate Cancer*

M. Hance, J. Isaacs, I. Garraway, 2012, The Journal of Biological Chemistry.

Extracellular Hsp90 serves as a co-factor for MAPK activation and latent viral gene expression during de novo infection by KSHV.

J. Isaacs, Z. Qin, C. Parsons, 2010, Virology.

A Novel Extracellular Hsp90 Mediated Co-Receptor Function for LRP1 Regulates EphA2 Dependent Glioblastoma Cell Invasion

J. Isaacs, E. Garrett-Mayer, Angen Liu, 2011, PloS one.

Simultaneous inhibition of hsp 90 and the proteasome promotes protein ubiquitination, causes endoplasmic reticulum-derived cytosolic vacuolization, and enhances antitumor activity.

L. Neckers, J. Isaacs, D. Gius, 2004, Molecular cancer therapeutics.

Molecular and functional crosstalk between extracellular Hsp90 and ephrin A1 signaling

J. Isaacs, J. Kaur, U. Gopal, 2017, Oncotarget.

Molecular and functional crosstalk between extracellular Hsp 90 and ephrin A 1 signaling

J. Isaacs, J. Kaur, U. Gopal, 2017 .

Tumor-secreted Hsp90 Subverts Polycomb Function to Drive Prostate Tumor Growth and Invasion*

M. Hance, O. Franco, S. Hayward, 2015, The Journal of Biological Chemistry.

The Double-Edged Sword: Conserved Functions of Extracellular Hsp90 in Wound Healing and Cancer

M. Hance, J. Isaacs, K. D. Nolan, 2014, Cancers.

Hsp 90 as a Gatekeeper of Tumor Angiogenesis : Clinical Promise and Potential Pitfalls

J. Isaacs, U. Gopal, J. Bohonowych, 2014 .

Hsp90 as a Gatekeeper of Tumor Angiogenesis: Clinical Promise and Potential Pitfalls

J. Isaacs, U. Gopal, J. Bohonowych, 2010, Journal of oncology.

Hsp90 as a "Chaperone" of the Epigenome: Insights and Opportunities for Cancer Therapy.

J. Isaacs, 2016, Advances in cancer research.

Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway*

L. Neckers, J. Isaacs, Yun-jin Jung, 2002, The Journal of Biological Chemistry.

Secreted heat shock protein 90 promotes prostate cancer stem cell heterogeneity

J. Isaacs, J. Kaur, K. D. Nolan, 2016, Oncotarget.

Heat-shock protein 90 inhibitors in antineoplastic therapy: is it all wrapped up?

J. Isaacs, 2005, Expert opinion on investigational drugs.

Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.

James B. Mitchell, M. Brechbiel, L. Neckers, 2003, Cancer research.

IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis.

Yun-Jin Jung, L. Neckers, J. Isaacs, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Label-Free Relative Quantitation of Isobaric and Isomeric Human Histone H2A and H2B Variants by Fourier Transform Ion Cyclotron Resonance Top-Down MS/MS.

S. Dalton, J. Dennis, J. Isaacs, 2016, Journal of proteome research.

Microtubule Disruption Utilizes an NFκB-dependent Pathway to Stabilize HIF-1α Protein*

L. Neckers, J. Isaacs, J. Trepel, 2003, The Journal of Biological Chemistry.

Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway.

L. Neckers, J. Isaacs, Yun-jin Jung, 2002, The Journal of biological chemistry.

Award Number: W81XWH-12-1-0324 TITLE: Extracellular Hsp90 as a Novel Epigenetic of EMT and Metastatic Risk in Prostate Cancer

J. Isaacs, 2014 .

Extracellular Hsp90 mediates an NF‐κB dependent inflammatory stromal program: Implications for the prostate tumor microenvironment

M. Hance, J. Isaacs, C. Parsons, 2014, The Prostate.

Microtubule disruption utilizes an NFkappa B-dependent pathway to stabilize HIF-1alpha protein.

L. Neckers, J. Isaacs, J. Trepel, 2003, The Journal of biological chemistry.

Heat shock protein 90 as a molecular target for cancer therapeutics.

L. Neckers, J. Isaacs, Wanping Xu, 2003, Cancer cell.