M. Kukhanova

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Excision of β-L- and β-D-Nucleotide Analogs From DNA by p53 Protein

Yung-chi Cheng, H. Pelicano, M. Kukhanova, 2000 .

Nucleoside 5'-triphosphates modified at sugar residues as substrates for calf thymus terminal deoxynucleotidyl transferase and for AMV reverse transcriptase.

A. Mazo, M. Kukhanova, R. Beabealashvilli, 1986, Biochimica et biophysica acta.

Biographical Sketch

M. Kukhanova, N. Tarussova, 2000, Nucleosides, nucleotides & nucleic acids.

Intracellular metabolism and pharmacokinetics of 5'-hydrogenphosphonate of 3'-azido-2',3'-dideoxythymidine, a prodrug of 3'-azido-2',3'-dideoxythymidine.

M. Kukhanova, K. Popov, I. Karpenko, 2004, Antiviral research.

5′-Aminocarbonyl Phosphonates as New Zidovudine Depot Forms: Antiviral Properties, Intracellular Transformations, and Pharmacokinetic Parameters

M. Kukhanova, S. Shram, M. Jasko, 2009, Drug Metabolism and Disposition.

Biographical Sketch

M. Kukhanova, N. Tarussova, 2000, Nucleosides, nucleotides & nucleic acids.

Mutations in the DNA polymerase and thymidine kinase genes of herpes simplex virus clinical isolates resistant to antiherpetic drugs

M. Skoblov, M. Kukhanova, S. Kochetkov, 2010, Molecular Biology.

Unique inhibitory effect of 1-(2'-deoxy-2'-fluoro-beta-L-arabinofuranosyl)-5-methyluracil 5'-triphosphate on Epstein-Barr virus and human DNA polymerases.

M. Kukhanova, Y. Cheng, Z. Y. Lin, 1998, Biochemical pharmacology.

Inhibition of Epstein-Barr virus replication by a novel L-nucleoside, 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil.

M. Kukhanova, Y. Cheng, C. K. Chu, 1996, Biochemical pharmacology.

Peptidyltransferase center of ribosomes

M. Kukhanova, A. Krayevsky, L. Victorova, 1983, FEBS letters.

2′-Fluoronucleotides as substrates of viral replicative polymerases

M. Kukhanova, S. Kochetkov, A. Azhayev, 2014, Molecular Biology.

Biographical sketch. Professor Alexander Krayevsky PhD, (1932-1999).

M. Kukhanova, N. Tarussova, 2000, Nucleosides, nucleotides & nucleic acids.

A Novel Action of Human Apurinic/Apyrimidinic Endonuclease

M. Kukhanova, K. Chou, Yung‐chi Cheng, 2000, The Journal of Biological Chemistry.

2',3'-Dideoxy-3' aminonucleoside 5'-triphosphates are the terminators of DNA synthesis catalyzed by DNA polymerases.

M. Kukhanova, R. Beabealashvilli, A. Krayevsky, 1984, Nucleic acids research.

Telomerase from human leukemia cells: properties and its interaction with deoxynucleoside analogues.

M. Kukhanova, Y. Cheng, G. Dutschman, 1998, Cancer research.

Development of the system ensuring a high-level expression of hepatitis C virus nonstructural NS5B and NS5A proteins.

M. Kukhanova, S. Kochetkov, A. Ivanov, 2006, Protein expression and purification.

Synthesis of thioamide bond catalyzed by E. coli ribosomes

M. Kukhanova, B. Gottikh, L. Victorova, 1976, FEBS letters.

Substrate properties of dinucleoside 5′,5″-oligophosphates in the reactions catalyzed by HIV reverse transcriptase, E. coli DNA polymerase I, and E. coli RNA polymerase

M. Kukhanova, Y. Skoblov, A. Skoblov, 2005, Russian Journal of Bioorganic Chemistry.

New Dinucleoside Phosphonate Derivatives as Prodrugs of 3′-Azido-3′-Deoxythymidine and β-L-2′,3′-Dideoxy-3′-Thiacytidine: Synthesis and Anti-HIV Properties

M. Kukhanova, P. N. Solyev, I. Karpenko, 2014, Nucleosides, nucleotides & nucleic acids.

Carbocyclic dinucleoside polyphosphonates: interaction with HIV reverse transcriptase and antiviral activity.

V. V. Zolin, M. Kukhanova, R. Beabealashvilli, 2002, Journal of medicinal chemistry.

Antiherpetic Properties of Acyclovir 5′‐Hydrogenphosphonate and the Mutation Analysis of Herpes Virus Resistant Strains

M. Skoblov, M. Kukhanova, I. Karpenko, 2009, Chemical biology & drug design.

Year : 2005 Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases beta and lambda

E. Crespan, S. Zanoli, G. Maga, 2006 .

Incorporation of non-nucleoside triphosphate analogues opposite to an abasic site by human DNA polymerases β and λ

E. Crespan, S. Zanoli, G. Maga, 2005, Nucleic acids research.

Synthesis of acyclic nucleoside analogues based on 1,2,4-triazolo[1,5-a]pyrimidin-7-ones by one-step Vorbrüggen glycosylation

M. Kukhanova, O. Chupakhin, V. Rusinov, 2014 .

Nucleoside 5'-triphosphates with modified sugars as substrates for DNA polymerases.

M. Kukhanova, R. Beabealashvilli, A. Krayevsky, 1986, Biochimica et biophysica acta.

Aminonucleosides and their derivatives. IV. Synthesis of the 3'-amino-3'-deoxynucleoside 5'-phosphates.

M. Kukhanova, S. Kochetkova, A. Krayevsky, 1979, Nucleic acids research.

Versatile synthesis of oxime-containing acyclic nucleoside phosphonates--synthetic solutions and antiviral activity.

M. Kukhanova, S. Kochetkov, P. N. Solyev, 2015, Organic & biomolecular chemistry.

1,2,4-Triazoloazine derivatives as a new type of herpes simplex virus inhibitors.

M. Kukhanova, O. Chupakhin, V. Rusinov, 2010, Bioorganic chemistry.

Nucleic Acids Research

V. Florentiev, M. P. Kirpichnikov, M. Kukhanova, 2022 .

3'-C-branched 2'-deoxy-5-methyluridines: synthesis, enzyme inhibition, and antiviral properties.

E. De Clercq, M. Kukhanova, J. Balzarini, 1992, Journal of medicinal chemistry.

Human herpes simplex virus: Life cycle and development of inhibitors

M. Kukhanova, S. Kochetkov, A. Korovina, 2014, Biochemistry (Moscow).

MOLECULAR BIOLOGICAL PROBLEMS OF THE CREATION OF DRUGS AND STUDY OF THE MECHANISMS OF THEIR ACTION APPROACHES TO THE SEARCH FOR DRUGS AGAINST AIDS

M. Kukhanova, A. Kraevskii, R. Bibilashvili, 2000 .

Peptidyl transferase center of Escherichia coli ribosomes: Interrelations between the substrates

M. Kukhanova, A. Krayevsky, M. Sprinzl, 1980, FEBS letters.

Antiviral Properties, Metabolism, and Pharmacokinetics of a Novel Azolo-1,2,4-Triazine-Derived Inhibitor of Influenza A and B Virus Replication

M. Kukhanova, S. Kochetkov, O. Kiselev, 2010, Antimicrobial Agents and Chemotherapy.

Metabolism of 2′,3′-Dideoxy-2′,3′-Didehydro-β-l(−)-5-Fluorocytidine and Its Activity in Combination with Clinically Approved Anti-Human Immunodeficiency Virus β-d(+) Nucleoside Analogs In Vitro

M. Kukhanova, E. Gullen, Shwu-Huey Liu, 1998, Antimicrobial Agents and Chemotherapy.

1,3-Dipolar cycloaddition of alkenes to 3’-azido-3’-deoxythymidine as a route to 3’-deoxythymidin-3’-yl derivatives

M. Kukhanova, P. N. Solyev, R. Novikov, 2014 .

Synthesis and Substrate Properties of Modified Nucleoside 5"-Triphosphates Mimicking dATP in the Reactions of DNA Synthesis Catalyzed by DNA Polymerases

M. Kukhanova, Y. Sharkin, L. S. Viktorova, 2001, Russian Journal of Bioorganic Chemistry.

Excision of b - D - and b - L -Nucleotide Analogs from DNA by the Human Cytosolic 3 9 -to-5 9 Exonuclease

H. Pelicano, M. Kukhanova, Yung‐chi Cheng, 2000 .

Interaction of beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluoro-CTP with human immunodeficiency virus-1 reverse transcriptase and human DNA polymerases: implications for human immunodeficiency virus drug design.

M. Kukhanova, Y. Cheng, W. Prusoff, 1998, Molecular pharmacology.

Excision of β-D- and β-L-nucleotide analogs from DNA by the human cytosolic 3'-to-5' exonuclease

H. Pelicano, M. Kukhanova, Yung‐chi Cheng, 2000 .

Beta-L-(-)-dioxolane Cytidine (β-L-(-)-OddC) as a Potent Compound for the Treatment of Cancer

M. Kukhanova, C. K. Chu, Shwu-Huey Liu, 1997 .

L- and D-Enantiomers of 2′,3′-Dideoxycytidine 5′-Triphosphate Analogs as Substrates for Human DNA Polymerases

M. Kukhanova, C. K. Chu, Shwu-Huey Liu, 1995, The Journal of Biological Chemistry.

Design of anti-HIV compounds: from nucleoside to nucleoside 5'-triphosphate analogs. Problems and perspectives.

M. Kukhanova, Y. Cheng, W. Prusoff, 2000, Current pharmaceutical design.

Selective Inhibition of DNA Chain Elongation Catalyzed by DNA Polymerases

M. Kukhanova, R. Beabealashvilli, A. Krayevsky, 1988 .

Formation of phosphonester bonds catalyzed by DNA polymerase.

M. Kukhanova, A. Krayevsky, A. Atrazhev, 1992, Nucleic acids research.

Adenosine N1-Oxide Analogues as Inhibitors of Orthopox Virus Replication

M. Kukhanova, I. Karpenko, A. Khandazhinskaya, 2006 .

Cell Metabolism of Acyclovir Phosphonate Derivatives and Antiherpesvirus Activity of their Combinations with α2‐Interferon

M. Kukhanova, I. Karpenko, M. Jasko, 2007, Chemical biology & drug design.

Properties of 2′,3′‐dideoxy‐2′,3′‐dehydrothymidine 5′‐triphosphate in terminating DNA synthesis catalyzed by several different DNA polymerases

M. Kukhanova, A. Krayevsky, R. Beabealashvilli, 1987, FEBS letters.

Cellular metabolism of modified nucleosides that suppress production of human immunodeficiency virus. III. (Review)

M. Kukhanova, A. Kraevskii, 1992, Pharmaceutical Chemistry Journal.

Synthesis and Antiherpetic Activity of Acyclovir Phosphonates

M. Kukhanova, I. Karpenko, M. Jasko, 2003, Nucleosides, nucleotides & nucleic acids.

Modified substrates of DNA polymerases and design of antivirals.

M. Kukhanova, A. Krayevsky, L. Alexandrova, 1996, Acta Biochimica Polonica.

Acute and Delayed Toxicity Studies on the Antiherpesvirus Agents 5-Methoxymethyl-2′-Deoxycytidine and 5-Methoxymethyl-2′-Deoxyuridine

M. Kukhanova, Y.‐C. Cheng, R. Shi, 1997 .

Uncharged AZT and D4T derivatives of phosphonoformic and phosphonoacetic acids as anti-HIV pronucleosides.

V. Mitkevich, M. Kukhanova, E. Bocharov, 2004, Journal of medicinal chemistry.

2\',3\'-dideoxy-3\'-aminonucleoside-5\'-triphosphates inhibit repair DNA synthesis in rat liver chromatin

M. Kukhanova, N. Belyakova, L. Alexandrova, 1985 .

Inhibition of replicative DNA synthesis in nuclei of sea urchin (Strongylocentrotus intermwium) embryo by 2\', 3\'-dideoxy-3\'-aminonucleoside 5\'-triphosphates

M. Kukhanova, V. Rasskazov, N. Terentieva, 1985 .

2',3'-Dideoxy-3'-aminonucleoside 5'-triphosphates inhibit the repair of DNA in rat liver chromatin.

M. Kukhanova, N. Belyakova, L. Alexandrova, 1984, Biochimica et Biophysica Acta.

Inhibition of replicative DNA synthesis in nuclei of Strongylocentrotus intermedium urchin embryo by 2',3'-dideoxy-3'-aminonucleoside 5'-triphosphates.

M. Kukhanova, V. Rasskazov, N. Terentyeva, 1984, Biochimica et biophysica acta.

Crystal structure of ammonium 3′-azido-3′-deoxythymidine-5′-aminocarbonylphosphonate hemihydrate: an anti-HIV agent

M. Kukhanova, I. S. Bushmarinov, G. Gurskaya, 2014, Acta crystallographica. Section E, Structure reports online.

Modified nucleoside 5'‐triphosphates containing 2',3'‐fused threemembered rings as substrates for different DNA polymerases

M. Kukhanova, A. Krayevsky, L. Victorova, 1993, FEBS letters.

Acyclic 2',3'-dideoxy-2', 3'-didehydronucleoside 5'-triphosphates as termination substrates of broad set of DNA polymerases

M. Kukhanova, A. Krayevsky, L. Victorova, 1993 .

Peptidyl transferase centre of bacterial ribosomes: substrate specificity and binding sites.

M. Kukhanova, B. Gottikh, A. Krayevsky, 1975, Nucleic acids research.

Synthesis and Anti‐HIV Properties of New Carbamate Prodrugs of AZT

M. Kukhanova, S. Kochetkov, P. N. Solyev, 2012, Chemical biology & drug design.

5′‐Phosphonate Derivatives of 2′,3′‐Dideoxy‐3′‐Thiacytidine as New Anti‐HIV Prodrugs

N. A. Golubeva, M. Kukhanova, P. N. Solyev, 2011, Chemical biology & drug design.

Anti-HIV nucleoside drugs: A retrospective view into the future

M. Kukhanova, 2012, Molecular Biology.

[Formation of phosphonoester bonds, catalyzed by DNA polymerases].

M. Kukhanova, A. Atrazhev, A. Kraevskii, 1991, Molekuliarnaia biologiia.

Phosphorylation of 3\'-deoxy-3\'-aminothymidine in the mouse myeloma p38ag653 cell culture and its incorporation into DNA

M. Kukhanova, S. Kochetkova, A. Krayevsky, 1985 .

New inhibitors of DNA and RNA biosynthesis in vitro and in vivo

M. Kukhanova, T. Kutateladze, A. Krayevsky, 1985 .

New modified substrates for discriminating between human DNA polymerases α and ϵ

M. Kukhanova, A. Krayevsky, D. J. Mozzherin, 1995 .

Synthesis of an unnatural P‐N bond catalyzed with Escherichia coli ribosomes

M. Kukhanova, R. Khomutov, L. Victorova, 1981, FEBS letters.

Does Interaction of dNTP Glycone with an Active Center of Reverse Transcriptases Takes Place? A Model for a Binding Site

M. Kukhanova, A. Krayevsky, N. Dyatkina, 1995 .

Phosphate-Modified Nucleotides: Conversions in Human Serum

M. Kukhanova, A. Krayevsky, A. Arzumanov, 1995 .

[Inhibitory analysis of DNA polymerases from human viruses using modified substrates].

M. Kukhanova, B. O'hara, J. Morin, 1994, Molekuliarnaia biologiia.

[Fluorescent analogs of nucleoside-5'-phosphates for the study of nucleic acids by nonradioactive methods].

T. Rozovskaia, M. Kukhanova, A. Atrazhev, 1990, Molekuliarnaia biologiia.

Pyrophosphate analogues in pyrophosphorolysis reaction catalyzed by DNA polymerases

M. Kukhanova, A. Krayevsky, A. Atrazhev, 1989, FEBS letters.

Some aspects of DNA polymerase functioning.

M. Kukhanova, R. Beabealashvilli, A. Krayevsky, 1987, Nucleic acids symposium series.

Synthesis and Substrate Properties of Thymidine 5′-Triphosphate Analogs with Large Hydrophobic Substituent Groups At α-P Atom

M. Kukhanova, A. Krayevsky, A. Arzumanov, 1995 .

Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity.

M. Kukhanova, S. Kochetkov, J. Vepsäläinen, 2016, Biochimie.

Hypophosphoric acid is a unique substrate of pyrophosphorolysis catalyzed by HIV-1 reverse transcriptase.

M. Kukhanova, A. Khomutov, N. Zakirova, 2005, Biochemical and biophysical research communications.

Synthesis and in vitro Biological Evaluation of Novel Thymidine Analogs Containing 1H-1,2,3-Triazolyl, 1H-Tetrazolyl, and 2H-Tetrazolyl Fragments

E. A. Popova, M. Kukhanova, V. Zarubaev, 2019, Nucleosides, nucleotides & nucleic acids.

New Lipophilic Derivatives of AZT and d4T 5′-Phosphonates

M. Kukhanova, A. Pokrovsky, M. Jasko, 2003, Nucleosides, nucleotides & nucleic acids.

The Effect of Pyrophosphate Analogues on the Activity of the Inorganic Pyrophosphatase from Escherichia coli

M. Kukhanova, N. Zakirova, Y. Skoblov, 2002, Russian Journal of Bioorganic Chemistry.

Hepatitis C virus helicase/NTPase: an efficient expression system and new inhibitors

N. A. Golubeva, M. Kukhanova, S. Kochetkov, 2008, Biochemistry (Moscow).

[Substrate inhibitors of DNA biosynthesis].

M. Kukhanova, A. Atrazhev, A. Kraevskii, 1987, Molekuliarnaia biologiia.

A new chemical method of synthesis of modified nucleoside [32P]phosphates

M. Kukhanova, E. Shirokova, D. Yanvarev, 2008 .

The Synthesis and Antiherpetic Activity of Acyclovir Phosphonate Esters

M. Kukhanova, I. Karpenko, M. Jasko, 2004, Russian Journal of Bioorganic Chemistry.

Synthesis and Antiherpetic Activity of Acyclovir Phosphonates.

M. Kukhanova, I. Karpenko, M. Jasko, 2003 .

Phosphorodiamides as Prodrugs for Antiviral Nucleosides

M. Kukhanova, A. Pokrovsky, A. V. Shipitsyn, 2003, Nucleosides, nucleotides & nucleic acids.

Aminoacyl derivatives of nucleosides, nucleotides, and polynucleotides: 16. Synthesis of dipeptidyl-tRNAs with fluorescent labels

M. Kukhanova, A. Kraevskii, L. A. Aleksandrova, 1977 .

5′-Carbamoylphosphonyl-[6-3H]-AZT as a Tool for Studying Metabolic Transformations of the Nonradioactive Counterpart, an Inhibitor of HIV Replication

M. Kukhanova, E. Shirokova, D. Yanvarev, 2007, Nucleosides, nucleotides & nucleic acids.

Inhibition of Human Immunodeficiency Virus (HIV) Production by 5′-Hydrogenphosphonates of 3′-Azido-2′,3′- dideoxynucleosides

M. Kukhanova, V. Lukashov, A. Krayevsky, 1991 .

Synthesis and Substrate Properties of Thymidine 5′-Triphosphate Analogues with Large Hydrophobic Substituent Groups at α-P Atom.

M. Kukhanova, A. Krayevsky, A. Arzumanov, 1995 .

[Inhibitory analysis of DNA polymerase of herpes simplex type 1].

M. Kukhanova, B. O'hara, J. Morin, 1994, Molekuliarnaia biologiia.

On the mechanism of peptide bond synthesis in the ribosome. 3′‐O‐phenylalanyl‐2′‐O‐methyladenosine as a peptide acceptor

M. Kukhanova, Y. Mitin, V. Pozdnyakov, 1972, FEBS letters.

Optimized synthesis of 3′-O-aminothymidine and evaluation of its oxime derivative as an anti-HIV agent

T. A. Martynova, M. Kukhanova, P. N. Solyev, 2015 .

DEAD-box RNA Helicase DDX3: Functional Properties and Development of DDX3 Inhibitors as Antiviral and Anticancer Drugs

M. Kukhanova, A. Ivanov, I. Karpenko, 2020, Molecules.

Human herpes simplex virus: Life cycle and development of inhibitors

M. Kukhanova, S. Kochetkov, A. Korovina, 2014, Biochemistry (Moscow).

Expanding the repertoire of DNA polymerase substrates: template-instructed incorporation of non-nucleoside triphosphate analogues by DNA polymerases β and λ

E. Crespan, G. Maga, M. Kukhanova, 2006, Nucleic acids research.

The donor site of the peptidyltransferase center of ribosomes

M. Kukhanova, A. Azhayev, B. Gottikh, 1979, FEBS letters.

Ribosomes of rat liver catalyze ‘minimal’ donor reaction

M. Kukhanova, J. Stahl, B. Gottikh, 1979, FEBS letters.

Synthesis of acylamino acid esters of nucleoside 5'-phosphates and their investigation with PMR and CD spectra.

V. Florentiev, M. P. Kirpichnikov, M. Kukhanova, 1977, Nucleic acids research.

The study of the stimulating mechanism of the peptidyl donor activity of 2′(3′)‐O‐(N‐formylmethionyl)‐adenosine‐5′‐phosphate in peptidyl transferase of E. coli ribosome

M. Kukhanova, N. Tarussova, B. Gottikh, 1976, FEBS Letters.

On substrate specificity of the donor site of the Escherichia coli ribosomal peptidyl transferase center

M. Kukhanova, L. Victorova, S. Bourd, 1982, FEBS letters.

Kinetic constants for model substrates of peptidyltransferase donor site of Escherichia coli ribosomes

M. Kukhanova, B. Gottikh, A. Krayevsky, 1979, FEBS letters.

Catalysis of the peptide bond formation by 50 S subunits of E. Coli ribosomes with N-(formyl) methionine ester of adenylic acid as peptide donor

M. Kukhanova, B. Gottikh, A. Krayevsky, 1976, Molecular Biology Reports.

Cooperative effects in the peptidyltransferase center of Escherichia coli ribosomes.

M. Kukhanova, B. Gottikh, A. Krayevsky, 1983, European journal of biochemistry.

Peptidyl-tRNA with a fluorescent label: Ribosome substrates in peptide bond formation

M. Kukhanova, L. Alexandrova, B. Gottikh, 1974, Molecular Biology Reports.

Binding of oxytetracycline to E. coli ribosomes

M. Kukhanova, B. Gottikh, G. Gursky, 1974, Molecular Biology Reports.

Peptidyltransferase activity of 60S ribosomal subunit from wheat germ.

M. Kukhanova, M. Sikorski, A. Legocki, 1982, Acta biochimica Polonica.

Anti-HIV nucleoside drugs: A retrospective view into the future

M. Kukhanova, 2012, Molecular Biology.

New triphosphate conjugates bearing reporter groups: labeling of DNA fragments for microarray analysis.

M. Kukhanova, A. Zasedatelev, A. Chudinov, 2007, Bioconjugate chemistry.

Hepatitis C Virus RNA-Dependent RNA Polymerase Is Regulated by Cysteine S-Glutathionylation

B. Bartosch, M. Kukhanova, S. Kochetkov, 2019, Oxidative medicine and cellular longevity.

New Nonnucleoside Substrates for Terminal Deoxynucleotidyl Transferase: Synthesis and Dependence of Substrate Properties on Structure

M. Kukhanova, M. Jasko, A. Khandazhinskaya, 2005, Russian journal of bioorganic chemistry.

Aryl-Containing Esters Of Triphosphoric Acid As Substrates Of Terminal Deoxynucleotidyl Transferase

M. Kukhanova, M. Jasko, L. Alexandrova, 2007, Nucleosides, nucleotides & nucleic acids.

Synthesis of Novel Alkyl Triphosphates and Their Substrate Properties Toward Terminal Deoxynucleotidyltransferase

M. Kukhanova, A. Ivanov, M. Jasko, 2007, Nucleosides, nucleotides & nucleic acids.

New substrates of terminal deoxynucleotidyl transferase: Synthesis and biological evaluation

M. Kukhanova, M. Jasko, A. Khandazhinskaya, 2002 .

Hepatitis C virus NS5A protein modulates template selection by the RNA polymerase in in vitro system

V. Prassolov, A. Makarov, V. Mitkevich, 2009, FEBS letters.