J. Houghton

发表

Radiosensitivity of thymidylate synthase-deficient human tumor cells is affected by progression through the G1 restriction point into S-phase: implications for fluoropyrimidine radiosensitization.

H. Hwang, T. Davis, J. Houghton, 2000, Cancer research.

Selective sensitization to DNA-damaging agents in a human rhabdomyosarcoma cell line with inducible wild-type p53 overexpression.

J. Houghton, A. Gibson, F. G. Harwood, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma

J. Cleveland, P. Houghton, J. Houghton, 2005, The Journal of cell biology.

Regulation of FasL by NF-κB and AP-1 in Fas-dependent Thymineless Death of Human Colon Carcinoma Cells*

D. Green, J. Houghton, F. G. Harwood, 2000, The Journal of Biological Chemistry.

O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea.

P. Houghton, J. Houghton, T. Brent, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Phase II testing of melphalan in children with newly diagnosed rhabdomyosarcoma: a model for anticancer drug development.

S. George, P. Houghton, J. Houghton, 1988, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Molecular Targeting of Cell Death Signal Transduction Pathways in Cancer

J. Houghton, I. Peták, L. Kopper, 2006 .

Reduced folates and fluoropyrimidine antitumor efficacy.

P. Houghton, J. Houghton, 1989, Cancer treatment and research.

Characteristics of thymidylate synthase purified from a human colon adenocarcinoma.

P. Houghton, J. Houghton, S. Radparvar, 1988, Archives of biochemistry and biophysics.

Reactive oxygen species regulate caspase activation in tumor necrosis factor-related apoptosis-inducing ligand-resistant human colon carcinoma cell lines.

J. Houghton, D. Tillman, K. Izeradjene, 2005, Cancer research.

ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum

Q. Wang, M. Sleeman, J. Houghton, 2008, Developmental dynamics : an official publication of the American Association of Anatomists.

Fas-dependent and -independent mechanisms of cell death following DNA damage in human colon carcinoma cells.

J. Houghton, F. G. Harwood, D. Tillman, 2000, Cancer research.

Hedgehog Signaling Regulates Telomerase Reverse Transcriptase in Human Cancer Cells

J. Houghton, Bibo Li, M. Qadan, 2013, PloS one.

Material Supplementary Cited Articles E-mail Alerts the Novel Polyamine Analogue Cgc-11093 Enhances the Antimyeloma Activity of Bortezomib

J. Cleveland, J. Rehg, L. Marton, 2022 .

Locus of the interaction among 5-fluorouracil, leucovorin, and interferon-alpha 2a in colon carcinoma cells.

C. Morton, J. Houghton, A. Rahman, 1993, Cancer research.

Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae.

F. Desmots, J. Houghton, L. Elghazi, 2005, Cancer research.

Interferon-gamma-induced sensitization of colon carcinomas to ZD9331 targets caspases, downstream of Fas, independent of mitochondrial signaling and the inhibitor of apoptosis survivin.

J. Houghton, D. Tillman, J. Geller, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Modulation of the Fas signaling pathway by IFN-gamma in therapy of colon cancer: phase I trial and correlative studies of IFN-gamma, 5-fluorouracil, and leucovorin.

J. Houghton, D. Tillman, M. Tan, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Erratum (Retracted article): FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma (Journal of Cell Biology (2005) 170, 6, (903-912))

J. Cleveland, P. Houghton, J. Houghton, 2007 .

Interferon-gamma pharmacokinetics and pharmacodynamics in patients with colorectal cancer

J. Panetta, J. Houghton, D. Tillman, 2004, Cancer Chemotherapy and Pharmacology.

triphosphate Influences the Commitment of Human Colon Carcinoma Cells to Thymineless Death1

J. Houghton, F. G. Harwood, D. Tillman, 1995 .

Potentiation of 5-Fluorouracil-[6RS]leucovorin cytotoxicity by recombinant human Interferon-α2A in colon carcinoma cells

P. Houghton, J. Houghton, D. A. Adkins, 1994 .

Enhanced cytotoxicity of 5-fluorouracil combined with [6RS]leucovorin and recombinant human interferon-alpha 2a in colon carcinoma cells.

P. Houghton, J. Houghton, D. A. Adkins, 1993, Advances in experimental medicine and biology.

Biochemical determinants of responsiveness to 5-fluorouracil and its derivatives in xenografts of human colorectal adenocarcinomas in mice.

P. Houghton, J. Houghton, S. J. Maroda, 1981, Cancer research.

Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against pediatric and adult central nervous system tumor xenografts

C. B. Hare, S. Keir, D. Bigner, 1996, Cancer Chemotherapy and Pharmacology.

Phase II study of 5‐fluorouracil/leucovorin for pediatric patients with malignant solid tumors

J. Houghton, E. Douglass, W. Meyer, 1994, Cancer.

Cloning and expression of human endothelial-monocyte-activating polypeptide 2 (EMAP-2) and identification of its putative precursor.

J. Houghton, T. Tolmachova, J. Carmichael, 1997, Cytokine.

Modulation by verapamil of vincristine pharmacokinetics and toxicity in mice bearing human tumor xenografts.

P. Houghton, J. Horton, J. Houghton, 1989, Biochemical pharmacology.

Pediatric rhabdomyosarcoma cell lines are resistant to Fas-induced apoptosis and highly sensitive to TRAIL-induced apoptosis.

J. Houghton, D. Tillman, I. Peták, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

Proteasome inhibitors abolish cell death downstream of caspase activation during anti-microtubule drug-induced apoptosis in leukemia cells.

J. Houghton, G. Imre, I. Peták, 2005, Anticancer research.

Determinants of intrinsic sensitivity to Vinca alkaloids in xenografts of pediatric rhabdomyosarcomas.

P. Houghton, J. Houghton, P. Torrance, 1984, Cancer research.

Studies with 4'-deoxyepivincristine (vinepidine), a semisynthetic vinca alkaloid.

P. Houghton, J. Houghton, M. Horowitz, 1985, Biochemical pharmacology.

Shared pathways: Death receptors and cytotoxic drugs in cancer therapy

J. Houghton, I. Peták, 2009, Pathology Oncology Research.

The effect of derivatives of folic acid on the fluorodeoxyuridylate-thymidylate synthetase covalent complex in human colon xenografts.

P. Houghton, J. Houghton, C. Schmidt, 1982, European journal of cancer & clinical oncology.

Caveolae Signaling Complex Components into Ceramide-Enriched Clustering of DR 5 and Concentrating Death-Inducing Carcinoma Cells to TRAIL-Induced Apoptosis through Cyclooxygenase-2 Inhibition Sensitizes Human Colon

F. Desmots, J. Houghton, L. Elghazi, 2005 .

Cell Cycle Control Processes Determine Cytostasis or Cytotoxicity in Thymineless Death of Colon Cancer Cells 1

P. Houghton, J. Houghton, F. G. Harwood, 2022 .

Influence of Casein Kinase II in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand-Induced Apoptosis in Human Rhabdomyosarcoma Cells

J. Houghton, K. Izeradjene, L. Douglas, 2004, Clinical Cancer Research.

Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells.

J. Houghton, T. Shi, T. Mazumdar, 2011, Cancer research.

Hedgehog signaling drives cellular survival in human colon carcinoma cells.

J. Houghton, T. Shi, T. Mazumdar, 2011, Cancer research.

Therapeutics , Targets , and Chemical Biology Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells

J. Houghton, T. Shi, T. Mazumdar, 2011 .

A caspase-8-independent component in TRAIL/Apo-2L-induced cell death in human rhabdomyosarcoma cells

J. Houghton, D. Tillman, K. Izeradjene, 2003, Cell Death and Differentiation.

The fas signaling pathway is functional in colon carcinoma cells and induces apoptosis.

J. Houghton, A. Gibson, F. G. Harwood, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Influence of dose of [6RS]leucovorin on reduced folate pools and 5-fluorouracil-mediated thymidylate synthase inhibition in human colon adenocarcinoma xenografts.

P. Houghton, J. Houghton, P. Cheshire, 1990, Cancer research.

Relationship between dose rate of [6RS]Leucovorin administration, plasma concentrations of reduced folates, and pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in human colon adenocarcinoma xenografts.

P. Houghton, J. Houghton, P. Cheshire, 1990, Cancer research.

Effect of polyglutamylation of 5,10-methylenetetrahydrofolate on the binding of 5-fluoro-2'-deoxyuridylate to thymidylate synthase purified from a human colon adenocarcinoma xenograft.

P. Houghton, J. Houghton, S. Radparvar, 1989, Biochemical pharmacology.

Use of investigational drugs as initial therapy for childhood solid tumors.

P. Houghton, J. Houghton, W. Meyer, 1989, Haematology and blood transfusion.

Evaluation of 9-dimethylaminomethyl-10-hydroxycamptothecin against xenografts derived from adult and childhood solid tumors

P. Houghton, J. Houghton, C. Stewart, 2004, Cancer Chemotherapy and Pharmacology.

Evaluation of 3-(p-fluorophenyl)-l-alanyl-3-[m-bis(2-chloroethyl)aminophenyl]-l-alanyl-l-methionine ethyl ester HCl (PTT.119) against xenografts of human rhabdomyosarcoma

P. Houghton, J. Houghton, J. Holland, 2004, Cancer Chemotherapy and Pharmacology.

Reciprocal cross-resistance in human rhabdomyosarcomas selected in vivo for primary resistance to vincristine and L-phenylalanine mustard.

P. Houghton, J. Horton, J. Houghton, 1987, Cancer research.

Preclinical and Clinical Modulation of Anticancer Drugs

P. Houghton, K. Tew, J. Houghton, 1993 .

Antitumor diarylsulfonylureas: novel agents with unfulfilled promise

P. Houghton, J. Houghton, 2004, Investigational New Drugs.

Evidence for mitochondrial localization of N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl)urea in human colon adenocarcinoma cells.

J. Howbert, P. Houghton, J. Houghton, 1990, Cancer research.

Ratio of 2'-deoxyadenosine-5'-triphosphate/thymidine-5'-triphosphate influences the commitment of human colon carcinoma cells to thymineless death.

J. Houghton, F. G. Harwood, D. Tillman, 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.

Interaction between 5-fluorouracil, [6RS]leucovorin, and recombinant human interferon-alpha 2a in cultured colon adenocarcinoma cells.

P. Houghton, J. Houghton, A. Rahman, 1991, Cancer communications.

5-Fluorouracil in combination with hypoxathine and allopurinol: toxicity and metabolism in xenografts of human colonic carcinomas in mice.

P. Houghton, J. Houghton, 1980, Biochemical pharmacology.

Growth and Differentiation of a Human T-Cell Leukemia Cell Line , CCRF-CEM , Grafted in Mice 1

Joseph, S. Raimondi, P. Houghton, 2006 .

Suppression of Interleukin‐5 Prevents Mortality in BALB/C Mice Infected with Cowdria ruminantiuma

R. Coffman, J. Houghton, N. Kock, 1998, Annals of the New York Academy of Sciences.

Relationship between binding affinity, retention and sensitivity of human rhabdomyosarcoma xenografts to Vinca alkaloids.

S. George, R. Dodge, P. Houghton, 1987, Biochemical pharmacology.

GTP influences the binding of vincristine in human tumor cytosols.

P. Houghton, J. Houghton, L. Bowman, 1986, Biochemical and biophysical research communications.

Stability of vincristine complexes in cytosols derived from xenografts of human rhabdomyosarcoma and normal tissues of the mouse.

P. Houghton, J. Houghton, L. Williams, 1985, Cancer research.

Mechanism of induction of gastrointestinal toxicity in the mouse by 5-fluorouracil, 5-fluorouridine, and 5-fluoro-2'-deoxyuridine.

P. Houghton, J. Houghton, R. Wooten, 1979, Cancer research.

Casein kinase II (CK2) enhances death-inducing signaling complex (DISC) activity in TRAIL-induced apoptosis in human colon carcinoma cell lines

J. Houghton, K. Izeradjene, L. Douglas, 2005, Oncogene.

Cellular pharmacology of 5-fluorouracil in a human colon adenocarcinoma cell line selected for thymidine kinase deficiency.

P. Houghton, J. Houghton, J. Pennington, 1990, Biochemical pharmacology.

Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors

P. Houghton, H. Friedman, J. Houghton, 2004, Cancer Chemotherapy and Pharmacology.

Growth characteristics of human colorectal tumours during serial passage in immune-deprived mice.

D. Taylor, J. Houghton, 1978, British Journal of Cancer.

Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer

J. Houghton, Tapati Mazumdar, Janet A. Houghton, 2012, Oncotarget.

The selectivity of action of methotrexate in combination with 5-fluorouracil in xenografts of human colon adenocarcinomas.

P. Houghton, J. Houghton, A. J. Tice, 1982, Molecular pharmacology.

Development and characterization of pediatric osteosarcoma xenografts.

A. Look, P. Houghton, J. Houghton, 1990, Cancer Research.

Morphological and Molecular Characterization of Spontaneous Myogenic Differentiation in a Human Rhabdomyosarcoma Cell Line1

P. Houghton, J. Houghton, G. Germain, 2006 .

Evidence for Mitochondria! Localization of yV-(4-Methylphenylsulfonyl)-jY'-(4-chlorophenyl)urea in Human Colon Adenocarcinoma Cells

J. Howbert, P. Houghton, F. Bailey, 2006 .

Line Myogenic Differentiation in a Human Rhabdomyosarcoma Cell Morphological and Molecular Characterization of Spontaneous Updated

P. Houghton, J. Houghton, G. Germain, 2006 .

Morphological and molecular characterization of spontaneous myogenic differentiation in a human rhabdomyosarcoma cell line.

P. Houghton, J. Houghton, G. Germain, 1990, Cancer research.

Characterization of cell lines derived from xenografts of childhood rhabdomyosarcoma.

P. Houghton, J. Houghton, E. Douglass, 1987, Cancer research.

Rhabdomyosarcoma. From the laboratory to the clinic.

P. Houghton, J. Houghton, D. Shapiro, 1991, Pediatric clinics of North America.

Development and characterization of a human colon adenocarcinoma xenograft deficient in thymidine salvage.

P. Houghton, J. Houghton, G. Germain, 1987, Cancer research.

On the mechanism of cytotoxicity of fluorinated pyrimidines in four human colon adenocarcinoma xenografts maintained in immune‐deprived mice

P. Houghton, J. Houghton, 1980, Cancer.

Development and Characterization of a Human Colon Adenocarcinoma Xenograft Deficient in Thymidine Salvage1

P. Houghton, J. Houghton, G. Germain, 2006 .

Development and characterization of a human colon adenocarcinoma xenograft deficient in thymidine salvage.

P. Houghton, J. Houghton, G. Germain, 1987, Cancer research.

Evaluation of N-(5-indanylsulfonyl)-N′-(4-chlorophenyl)-urea against xenografts of pediatric rhabdomyosarcoma

J. Howbert, P. Houghton, J. Houghton, 2004, Cancer Chemotherapy and Pharmacology.

Studies on the cellular pharmacology of N-(4-methylphenylsulfonyl)-N'-(4-chlorophenyl)-urea.

J. Howbert, P. Houghton, J. Houghton, 1990, Biochemical pharmacology.

N-(5-indanylsulfonyl)-N'-(4-chlorophenyl)urea, a novel agent equally cytotoxic to nonproliferating human colon adenocarcinoma cells.

P. Houghton, J. Houghton, G. Germain, 1990, Cancer research.

Relationship between 5-fluoro-2'-deoxyuridylate, 2'-deoxyuridylate, and thymidylate synthase activity subsequent to 5-fluorouracil administration, in xenografts of human colon adenocarcinomas.

P. Houghton, J. Houghton, P. Torrance, 1986, Biochemical pharmacology.

Binding of 5-fluorodeoxyuridylate to thymidylate synthase in human colon adenocarcinoma xenografts.

P. Houghton, J. Houghton, P. Torrance, 1986, European journal of cancer & clinical oncology.

Effects of cytotoxic agents on TdR incorporation and growth delay in human colonic tumour xenografts.

P. Houghton, D. Taylor, J. Houghton, 1977, British Journal of Cancer.

Absence of tRNA-guanine transglycosylase in a human colon adenocarcinoma cell line.

P. Houghton, U. Gündüz, J. Houghton, 1992, Biochimica et biophysica acta.

5-Halogenated Pyrimidines and Their Nucleosides

P. Houghton, J. Houghton, 1984 .

Bax is an important determinant of chemosensitivity in pediatric tumor cell lines independent of Bcl-2 expression and p53 status.

J. Houghton, L. Harris, D. Tillman, 1998, Oncology research.

Childhood rhabdomyosarcoma xenografts: responses to DNA-interacting agents and agents used in current clinical therapy.

P. Houghton, J. Houghton, P. Lutz, 1984, European journal of cancer & clinical oncology.

Therapeutic efficacy of the topoisomerase I inhibitor 7-ethyl-10-(4-[1-piperidino]-1-piperidino)-carbonyloxy-camptothecin against human tumor xenografts: lack of cross-resistance in vivo in tumors with acquired resistance to the topoisomerase I inhibitor 9-dimethylaminomethyl-10-hydroxycamptothecin.

P. Houghton, J. Houghton, M. Bissery, 1993, Cancer research.

Relationships between tumor responsiveness, vincristine pharmacokinetics and arrest of mitosis in human tumor xenografts.

P. Houghton, J. Horton, J. Houghton, 1988, Biochemical pharmacology.

Characterization of the pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in xenografts of human colon adenocarcinoma.

P. Houghton, J. Houghton, S. Radparvar, 1988, Cancer research.

Determination of thymidylate synthase activity in colon tumor tissues after treatment with 5-fluorouracil.

P. Houghton, J. Houghton, P. Torrance, 1987, Biochemical pharmacology.

Chromatographic analysis of Vinca alkaloids in human neoplastic tissues and host (mouse) tissues after injection in vivo or after incubation in vitro.

P. Houghton, J. Houghton, P. Torrance, 1983, Analytical biochemistry.

A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells.

J. Houghton, D. Tillman, I. Peták, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Thymineless death in colon carcinoma cells is mediated via fas signaling.

J. Houghton, F. G. Harwood, D. Tillman, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Maintenance of biological and biochemical characteristics of human colorectal tumours during serial passage in immune-deprived mice.

D. Taylor, J. Houghton, D. Taylor, 1978, British Journal of Cancer.

A specific chromosomal abnormality in rhabdomyosarcoma.

P. Houghton, M. Valentine, J. Houghton, 1987, Cytogenetics and cell genetics.

Role of murine tumor models in cancer treatment research.

P. Houghton, B. Fisher, J. Houghton, 1986, Cancer research.

Combinations of 5-FU, hypoxanthine and allopurinol in chemotherapy for human colon adenocarcinoma xenografts.

P. Houghton, J. Houghton, 1982, Cancer treatment reports.

Elucidation of pathways of 5-fluorouracil metabolism in xenografts of human colorectal adenocarcinoma.

P. Houghton, J. Houghton, 1983, European journal of cancer & clinical oncology.

Evaluation of single-agent therapy in human colorectal tumour xenografts.

P. Houghton, J. Houghton, 1978, British Journal of Cancer.

Influence of Dose of [6/?5]Leucovorin on Reduced Folate Pools and 5-Fluorouracil-mediated Thymidylate Synthase Inhibition in Human Colon Adenocarcinoma Xenografts1

P. Houghton, J. Houghton, P. Cheshire, 2006 .

Influence of guanine nucleotides on vincristine binding in tumor cytosols and purified tubulin: Evidence for an inhibitor of vincristine binding

P. Houghton, J. Houghton, L. Bowman, 1990, Journal of cellular physiology.

An antiapoptotic BCL-2 family expression index predicts the response of chronic lymphocytic leukemia to ABT-737.

J. Maciejewski, Kamini Singh, J. Houghton, 2011, Blood.

Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summary.

P. Meltzer, M. Ladanyi, E. Kleinerman, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Ceramide-induced G2 arrest in rhabdomyosarcoma (RMS) cells requires p21Cip1/Waf1 induction and is prevented by MDM2 overexpression

J. Hunt, J. Houghton, L. Harris, 2007, Cell Death and Differentiation.

Death Receptor Signaling in the Mechanism of 5-Fluorouracil Action

J. Houghton, 2003 .

Modulation of the Fas Signaling Pathway by IFN-γ in Therapy of Colon Cancer: Phase I Trial and Correlative Studies of IFN-γ, 5-Fluorouracil, and Leucovorin

J. Houghton, D. Tillman, M. Tan, 2002 .

p53 dependence of Fas induction and acute apoptosis in response to 5-fluorouracil-leucovorin in human colon carcinoma cell lines.

J. Houghton, D. Tillman, I. Peták, 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

p 53 Dependence of Fas Induction and Acute Apoptosis in Response to 5-Fluorouracil-Leucovorin in Human Colon Carcinoma Cell Lines 1

J. Houghton, D. Tillman, I. Peták, 2000 .

Inhibition of apoptosis after thymineless stress is conferred by oncogenic K-Ras in colon carcinoma cells.

J. Houghton, F. G. Harwood, D. Tillman, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Expression of genes that regulate Fas signalling and Fas-mediated apoptosis in colon carcinoma cells

J. Houghton, A. Gibson, F. G. Harwood, 1998, Cell Death and Differentiation.

Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance.

J. Cleveland, J. Houghton, Peng Huang, 2007, Blood.

Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.

J. Cleveland, D. McConkey, J. Houghton, 2008, Blood.

Chemotherapy of childhood rhabdomyosarcomas growing as xenografts in immune-deprived mice.

P. Houghton, J. Houghton, A. Green, 1982, Cancer research.

Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C.

J. Houghton, D. Tillman, K. Izeradjene, 2003, Cancer research.

Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing

J. Houghton, Ruowen Zhang, S. Ferrandon, 2016, Oncotarget.

Casein Kinase I Attenuates Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis by Regulating the Recruitment of Fas-Associated Death Domain and Procaspase-8 to the Death-Inducing Signaling Complex

J. Houghton, K. Izeradjene, L. Douglas, 2004, Cancer Research.

Apoptosis and drug response.

J. Houghton, 1999, Current opinion in oncology.

Cellular responses to antimetabolite anticancer agents: cytostasis versus cytotoxicity.

P. Houghton, J. Houghton, 1996, Progress in cell cycle research.

In Vivo Regulation of the Vi Antigen in Salmonella and Induction of Immune Responses with an In Vivo-Inducible Promoter

G. Dougan, J. Houghton, R. Kingsley, 2011, Infection and Immunity.

Histone deacetylase inhibitors enhance lexatumumab-induced apoptosis via a p21Cip1-dependent decrease in survivin levels.

J. Cleveland, J. Houghton, J. Carew, 2007, Cancer research.

P21Cip1 Is a Critical Mediator of the Cytotoxic Action of Thymidylate Synthase Inhibitors in Colorectal Carcinoma Cells

J. Houghton, J. Geller, I. Peták, 2004, Cancer Research.

P 21 Cip 1 Is a Critical Mediator of the Cytotoxic Action of Thymidylate Synthase Inhibitors in Colorectal Carcinoma Cells

J. Houghton, J. Geller, I. Peták, 2004 .

Cip 1 Is a Critical Mediator of the Cytotoxic Action of Thymidylate Synthase Inhibitors in Colorectal Carcinoma Cells

J. Houghton, J. Geller, I. Peták, 2004 .

ATP modulates PTEN subcellular localization in multiple cancer cell lines

C. Eng, J. Houghton, S. Planchon, 2008, Human molecular genetics.

Efficacy of systemic administration of irinotecan against neuroblastoma xenografts.

P. Houghton, J. Houghton, C. Stewart, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Development of resistance to vincristine in a childhood rhabdomyosarcoma growing in immune‐deprived mice

P. Houghton, J. Houghton, G. Brodeur, 1981, International journal of cancer.

Growth and characterization of childhood rhabdomyosarcomas as xenografts.

P. Houghton, J. Houghton, B. Webber, 1982, Journal of the National Cancer Institute.

Efficacy of oral irinotecan against neuroblastoma xenografts.

P. Houghton, J. Houghton, C. Stewart, 1997, Anti-cancer drugs.

Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding

B. Jha, J. Houghton, T. Mazumdar, 2014, Oncotarget.

Hypermethylation of the gene promoter and enhancer region can regulate Fas expression and sensitivity in colon carcinoma

L. Berczi, J. Houghton, D. Tillman, 2003, Cell Death and Differentiation.

Development and Characterization of Pediatrie Osteosarcoma Xenografts1

A. Look, P. Houghton, J. Houghton, 2006 .

Development and characterization of pediatric osteosarcoma xenografts.

A. Look, P. Houghton, J. Houghton, 1990, Cancer research.

Comparison of the conversion of 5-formyltetrahydrofolate and 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolates and tetrahydrofolates in human colon tumors.

P. Houghton, J. Houghton, P. Cheshire, 1989, Cancer communications.

Inhibition of NF-κB Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin

J. Houghton, T. Mazumdar, J. Devecchio, 2010, The Journal of Biological Chemistry.

Studies of the efficacy and pharmacology of irinotecan against human colon tumor xenograft models.

P. Houghton, J. Houghton, C. Poquette, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Proteasome inhibitors sensitize colon carcinoma cells to TRAIL-induced apoptosis via enhanced release of smac/DIABLO from the mitochondria

J. Houghton, K. Izeradjene, P. Conte, 2008, Pathology & Oncology Research.

The GLI genes as the molecular switch in disrupting Hedgehog signaling in colon cancer

J. Houghton, T. Shi, T. Mazumdar, 2011, Oncotarget.

cDNA Microarray Gene Expression Profiling of Hedgehog Signaling Pathway Inhibition in Human Colon Cancer Cells

Z. Duan, J. Houghton, M. Aziz, 2010, PloS one.

Development and characterization of human ependymoma xenograft HxBr5.

P. Houghton, J. Houghton, E. Douglass, 1987, Cancer research.

Schedule‐dependent Efficacy of Camptothecins in Models of Human Cancer a

P. Houghton, J. Houghton, M. Danks, 1996, Annals of the New York Academy of Sciences.

Serial cytogenetic studies of human colonic tumour xenografts.

J. Houghton, B. Reeves, 1978, British Journal of Cancer.

Biochemical mechanisms in colon xenografts: Thymidylate synthase as a target for therapy

P. Houghton, J. Houghton, S. Radparvar, 1989, Investigational New Drugs.

Evaluation of cytotoxic agents in human colonic tumor xenografts and mouse gastrointestinal tissues using a 3H-thymidine fractional incorporation assay.

P. Houghton, J. Houghton, 1979, European journal of cancer.

Formation and stability of vincristine-tubulin complex in kidney cytosols. Role of GTP and GTP hydrolysis.

P. Houghton, J. Houghton, L. Bowman, 1988, Biochemical pharmacology.

Acute and delayed apoptosis induced by thymidine deprivation correlates with expression of p53 and p53-regulated genes in colon carcinoma cells.

John Calvin Reed, S. Krajewski, J. Houghton, 1996, Oncogene.

Cell cycle control processes determine cytostasis or cytotoxicity in thymineless death of colon cancer cells.

P. Houghton, J. Houghton, F. G. Harwood, 1994, Cancer research.

Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft models

P. Houghton, L. Hertel, J. Houghton, 2004, Investigational New Drugs.

Factors that influence the therapeutic activity of 5-fluorouracil [6RS]leucovorin combinations in colon adenocarcinoma xenografts

P. Houghton, C. Morton, J. Houghton, 2004, Cancer Chemotherapy and Pharmacology.

Mutation(s) of the thymidylate synthase gene of human adenocarcinoma cells causes a thymidylate synthase-negative phenotype that can be attenuated by exogenous folates.

P. Houghton, C. Will, J. Houghton, 1992, Cancer research.

HypoxanthinerGuanine Phosphoribosyltransferase Activity in Xenografts of Human Osteosarcoma 1

P. Houghton, J. Houghton, W. Meyer, 2006 .

Hypoxanthine:guanine phosphoribosyltransferase activity in xenografts of human osteosarcoma.

P. Houghton, J. Houghton, W. Meyer, 1986, Cancer research.

Therapeutic efficacy of the cyclopropylpyrroloindole, carzelesin, against xenografts derived from adult and childhood solid tumors

P. Houghton, J. Houghton, P. Cheshire, 2004, Cancer Chemotherapy and Pharmacology.

Evaluation of a novel bis-naphthalimide anticancer agent, DMP 840, against human xenografts derived from adult, juvenile, and pediatric cancers

P. Houghton, J. Houghton, D. Dexter, 2004, Cancer Chemotherapy and Pharmacology.

Melphalan: a potential new agent in the treatment of childhood rhabdomyosarcoma.

P. Houghton, J. Houghton, P. Lutz, 1985, Cancer treatment reports.

Potentiation of 5-fluorouracil-leucovorin activity by alpha2a-interferon in colon adenocarcinoma xenografts.

C. Morton, J. Houghton, C. Stewart, 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.

Structural determinants of phenoxazine type compounds required to modulate the accumulation of vinblastine and vincristine in multidrug-resistant cell lines.

P. Houghton, W. T. Beck, J. Horton, 1990, Cancer communications.

Relationship between topotecan systemic exposure and tumor response in human neuroblastoma xenografts.

P. Houghton, J. Houghton, C. Poquette, 1998, Journal of the National Cancer Institute.

Evaluation of irinotecan in combination with 5-fluorouracil or etoposide in xenograft models of colon adenocarcinoma and rhabdomyosarcoma.

P. Houghton, J. Houghton, P. Cheshire, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Locus of the Interaction among 5-FIuorouraciI, Leucovorin, and Interferon-a2a in Colon Carcinoma Cells1

Atiqur, Christopher, J. Houghton, 2006 .

Mutants of human colon adenocarcinoma, selected for thymidylate synthase deficiency.

P. Houghton, J. Houghton, J. Pennington, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Sphingosine-induced apoptosis in rhabdomyosarcoma cell lines is dependent on pre-mitochondrial Bax activation and post-mitochondrial caspases.

J. Houghton, Sophie Martin, B. Doyle, 2007, Cancer research.

In situ selection of a human rhabdomyosarcoma resistant to vincristine with altered beta-tubulins.

P. Houghton, J. Houghton, E. Douglass, 1985, Cancer research.

A phase I trial of amsalog (CI-921) administered by intravenous infusion using a 5-day schedule

J. Carmichael, J. Houghton, P. Woll, 2001, Cancer Chemotherapy and Pharmacology.

Alpha 2a-interferon-induced differentiation of human alveolar rhabdomyosarcoma cells: correlation with down-regulation of the insulin-like growth factor type I receptor.

P. Houghton, J. Houghton, P. Dias, 1996, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Therapeutic selectivity of vinca alkaloids: a role for guanosine 5'-triphosphate?

P. Houghton, J. Houghton, B. Hazelton, 1987, Anti-cancer drug design.

Selectivity of CF and 5-fluorouracil: critical role of polyglutamylation.

P. Houghton, J. Houghton, J. Rodman, 1988, Advances in experimental medicine and biology.

Identification of STAT3-independent regulatory effects for protein inhibitor of activated STAT3 by binding to novel transcription factors

J. Houghton, A. Dowlati, S. Dabir, 2011, Cancer biology & therapy.

Development and Characterization of Human Ependymoma Xenograft HxBrS 1

P. Houghton, J. Houghton, E. Douglass, 2006 .

FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma

J. Cleveland, P. Houghton, J. Houghton, 2005, The Journal of cell biology.

Acknowledgment and Apology: Text Copied from Biochemical Journal

J. Houghton, K. Izeradjene, L. Douglas, 2005, Clinical Cancer Research.

Myc regulates aggresome formation, the induction of Noxa, and apoptosis in response to the combination of bortezomib and SAHA.

J. Cleveland, D. McConkey, J. Houghton, 2008, Blood.

Scheduling of vincristine: drug accumulation and response of xenografts of childhood rhabdomyosarcoma determined by frequency of administration.

P. Houghton, J. Houghton, W. Meyer, 1987, Cancer treatment reports.