K. Ohnishi

发表

Correlation between γ-ray-induced G2 arrest and radioresistance in two human cancer cells

H. Ohishi, H. Uchida, A. Takahashi, 1999 .

Accumulation of a tumor suppressor p53 protein in rat muscle during a space flight.

Y. Ohira, A. Takahashi, T. Ohnishi, 1999, Mutation research.

Contribution of protein kinase C to p53-dependent WAF1 induction pathway after heat treatment in human glioblastoma cell lines.

A. Takahashi, T. Ohnishi, K. Ohnishi, 1998, Experimental cell research.

p53-dependent Induction of WAF1 by Heat Treatment in Human Glioblastoma Cells*

A. Takahashi, T. Ohnishi, H. Matsumoto, 1996, The Journal of Biological Chemistry.

p53‐independent WAF1 induction by ACNU in human glioblastoma cells

Mitsutoshi Nakamura, A. Takahashi, T. Ohnishi, 1996, Molecular carcinogenesis.

UV-B light induces an adaptive response to UV-C exposure via photoreactivation activity in Euglena gracilis

A. Takahashi, N. Ishioka, T. Ohnishi, 2006, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Glycerol as a chemical chaperone enhances radiation-induced apoptosis in anaplastic thyroid carcinoma cells

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002, Molecular Cancer.

Glycerol restores heat-induced p53-dependent apoptosis of human glioblastoma cells bearing mutant p53

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002, BMC biotechnology.

Glycerol restores p53-dependent radiosensitivity of human head and neck cancer cells bearing mutant p53

A. Takahashi, T. Ohnishi, K. Ohnishi, 2000, British Journal of Cancer.

Restoration of mutant TP53 to normal TP53 function by glycerol as a chemical chaperone.

A. Takahashi, T. Ohnishi, K. Ohnishi, 1999, Radiation research.

Goldfish's visual information processing patterns in food-reinforced discrimination learning between compound visual stimuli

K. Ohnishi, 1991, Journal of Comparative Physiology A.

DNA damage recognition proteins localize along heavy ion induced tracks in the cell nucleus.

A. Takahashi, Katsunori Omori, N. Ishioka, 2008, Journal of radiation research.

Detection of DNA damages and repair in human culture cells with simulated space radiation.

A. Takahashi, T. Ohnishi, K. Ohnishi, 1999, Acta astronautica.

Accumulation of tumor suppressor p53 in rat muscle after a space flight.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2000, Advances in space research : the official journal of the Committee on Space Research.

siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells

A. Takahashi, T. Ohnishi, K. Ohnishi, 2011, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

siRNA Targeting NBS1 or XIAP Increases Radiation Sensitivity of Human Cancer Cells Independent of TP53 Status

R. Schiestl, A. Takahashi, T. Ohnishi, 2006, Radiation research.

Heat‐induced phosphorylation of NBS1 in human skin fibroblast cells

R. Schiestl, A. Takahashi, T. Ohnishi, 2006, Journal of cellular biochemistry.

High LET radiation enhances apoptosis in mutated p53 cancer cells through Caspase‐9 activation

A. Takahashi, T. Ohnishi, K. Ohnishi, 2008, Cancer Science.

Heat-induced growth inhibition and apoptosis in transplanted human head and neck squamous cell carcinomas with different status of p53

H. Ohishi, A. Takahashi, T. Ohnishi, 2003, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Induction of multinucleation in oral squamous cell carcinoma tissue with mutated p53 surviving boron neutron capture therapy

T. Ohnishi, Y. Yura, Y. Fujita, 2011, International journal of radiation biology.

High-LET radiation enhanced apoptosis but not necrosis regardless of p53 status.

A. Takahashi, T. Ohnishi, H. Matsumoto, 2004, International journal of radiation oncology, biology, physics.

WAF1 accumulation by carbon-ion beam and alpha-particle irradiation in human glioblastoma cultured cells.

A. Takahashi, T. Ohnishi, H. Matsumoto, 2000, International journal of radiation biology.

ATM is the predominant kinase involved in the phosphorylation of histone H2AX after heating.

David J. Chen, A. Takahashi, T. Ohnishi, 2010, Journal of radiation research.

Protein microarray analysis of apoptosis-related protein expression following heat shock in human tongue squamous cell carcinomas containing different p53 phenotypes

A. Takahashi, T. Ohnishi, K. Ohnishi, 2008, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Induction of radiation resistance by a heat shock protein inhibitor, KNK437, in human glioblastoma cells

A. Takahashi, T. Ohnishi, K. Ohnishi, 2006, International journal of radiation biology.

Potentiality of syringetin for preferential radiosensitization to cancer cells

K. Ohnishi, N. Kubota, H. Takemori, 2017, International journal of radiation biology.

Bifunctional effects of a protein kinase inhibitor (H-7) on heat-induced p53-dependent WAF1 accumulation.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1996, Experimental cell research.

The inhibitory effect of hypoxic cytotoxin on the expansion of cancer stem cells in ovarian cancer.

K. Ohnishi, H. Nagasawa, K. Morishige, 2015, Biochemical and biophysical research communications.

The Role of p53 Molecule in Radiation and Hyperthermic Therapies

A. Takahashi, T. Ohnishi, K. Ohnishi, 2003 .

Impact of the p53 Status of the Tumor Cells on the Effect of Reactor Neutron Beam Irradiation, with Emphasis on the Response of Intratumor Quiescent Cells

A. Takahashi, T. Ohnishi, K. Ono, 2002, Japanese journal of cancer research : Gann.

Wortmannin sensitizes human glioblastoma cell lines carrying mutant and wild type TP53 gene to radiation.

T. Ohnishi, K. Ohnishi, S. Okada, 2000, Cancer letters.

p53-dependent induction of WAF1 by a low-pH culture condition in human glioblastoma cells.

A. Takahashi, T. Ohnishi, T. Ohtsubo, 1997, Cancer research.

Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat stress.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1997, International journal of radiation oncology, biology, physics.

Glycerol enhances radiosensitivity in a human oral squamous cell carcinoma cell line (Ca9-22) bearing a mutant p53 gene via Bax-mediated induction of apoptosis.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2005, Oral oncology.

Transfection of mutant p53 gene depresses X-ray- or CDDP-induced apoptosis in a human squamous cell carcinoma of the head and neck

A. Takahashi, T. Ohnishi, H. Matsumoto, 2002, Apoptosis.

Transfection with mutant p53 gene inhibits heat-induced apoptosis in a head and neck cell line of human squamous cell carcinoma.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2000, International journal of radiation oncology, biology, physics.

Effects of protein kinase inhibitors on heat-induced hsp72 gene expression in a human glioblastoma cell line.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1998, Cellular signalling.

p53-dependent induction of WAF1 by cold shock in human glioblastoma cells

A. Takahashi, T. Ohnishi, K. Ohnishi, 1998, Oncogene.

The protein kinase inhibitor, H-7, suppresses heat-induced activation of heat shock transcription factor 1

A. Takahashi, T. Ohnishi, H. Matsumoto, 1999, Molecular and Cellular Biochemistry.

Poly(ADP-ribosyl)ation is required for p53-dependent signal transduction induced by radiation

A. Takahashi, T. Ohnishi, K. Ohnishi, 1998, Oncogene.

Apoptosis induced by high-LET radiations is not affected by cellular p53 gene status

A. Takahashi, N. Ishioka, T. Ohnishi, 2005, International journal of radiation biology.

Hyperthermic sensitizers targeting heat-induced signal transductions

T. Ohnishi, K. Ohnishi, 2007 .

The effects of microgravity on induced mutation in Escherichia coli and Saccharomyces cerevisiae.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2001, Advances in space research : the official journal of the Committee on Space Research.

Effectiveness of Hyperthermia on Cancer Stem Cells

K. Ohnishi, 2017 .

Suppression of heat-induced HSF activation by CDDP in human glioblastoma cells.

T. Ohnishi, H. Matsumoto, S. Hayashi, 1998, International journal of radiation oncology, biology, physics.

p53 Targeting can enhance cancer therapy via radiation, heat and anti-cancer agents.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2008, Anti-cancer agents in medicinal chemistry.

Effective enhancement of X-ray-induced apoptosis in human cancer cells with mutated p53 by siRNA targeting XIAP.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2008, Oncology reports.

Sensitization by glycerol for CDDP-therapy against human cultured cancer cells and tumors bearing mutated p53 gene

A. Takahashi, T. Ohnishi, K. Ohnishi, 2004, Apoptosis.

Effects of mild temperature hyperthermia and p53 status on the size of hypoxic fractions in solid tumors, with reference to the effect in intratumor quiescent cell populations.

A. Takahashi, T. Ohnishi, K. Ono, 2004, International journal of radiation oncology, biology, physics.

Usefulness of combined treatment with mild temperature hyperthermia and/or tirapazamine in the treatment of solid tumors: its independence of p53 status

A. Takahashi, T. Ohnishi, K. Ono, 2003, Cancer science.

Radiation-induced apoptosis in SCID mouse spleen after low dose or low dose-rate irradiation

A. Takahashi, T. Ohnishi, K. Ohnishi, 2004 .

Radiation-induced apoptosis in scid mice spleen after low dose irradiation.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2003, Advances in Space Research.

Radiation-induced apoptosis in the scid mouse spleen after low dose-rate irradiation

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002, International journal of radiation biology.

Nitric oxide is an initiator of intercellular signal transduction for stress response after hyperthermia in mutant p53 cells of human glioblastoma.

T. Ohnishi, H. Matsumoto, S. Hayashi, 1999, Cancer research.

Effects of p53 status and wortmannin treatment on potentially lethal damage repair, with emphasis on the response of intratumor quiescent cells.

A. Takahashi, T. Ohnishi, K. Ono, 2003, Radiation medicine.

Enhancement of membrane lipid peroxidation in lung cancer cells irradiated with monoenergetic X-rays at the K-shell resonance absorption peak of phosphorus

Hiromu Ito, K. Ohnishi, H. Majima, 2020, Journal of radiation research.

Radiation response of apoptosis in C57BL/6N mouse spleen after whole-body irradiation

A. Takahashi, T. Ohnishi, H. Matsumoto, 2001, International journal of radiation biology.

Transfection of p53-knockout mouse fibroblasts with wild-type p53 increases the thermosensitivity and stimulates apoptosis induced by heat stress.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1997, International journal of radiation oncology, biology, physics.

Detection of DNA damage induced by space radiation in Mir and space shuttle.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002, Journal of radiation research.

Biphasic effects of nitric oxide radicals on radiation-induced lethality and chromosome aberrations in human lung cancer cells carrying different p53 gene status.

A. Takahashi, T. Ohnishi, Xiaomin Su, 2010, International journal of radiation oncology, biology, physics.

DNA ligase IV is a potential molecular target in ACNU sensitivity

H. Nakase, A. Takahashi, T. Ohnishi, 2010, Cancer science.

Effects of p53 Status of Tumor Cells and Combined Treatment With Mild Hyperthermia, Wortmannin or Caffeine on Recovery From Radiation-Induced Damage

A. Takahashi, K. Ono, Minoru Suzuki, 2019, World journal of oncology.

Dependency of repair of radiation-induced damage on p53 status and efficient inhibition of the repair with wortmannin treatment in vivo, with reference to the effect on intratumor quiescent cell population.

A. Takahashi, T. Ohnishi, K. Ono, 2007, Oncology reports.

Effects of a heat shock protein inhibitor KNK437 on heat sensitivity and heat tolerance in human squamous cell carcinoma cell lines differing in p53 status

A. Takahashi, T. Ohnishi, K. Ohnishi, 2004, International journal of radiation biology.

Analysis of apoptosis-related gene expression after X-ray irradiation in human tongue squamous cell carcinoma cells harboring wild-type or mutated p53 gene.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2003, Journal of radiation research.

p53 -Dependent thermal enhancement of cellular sensitivity in human squamous cell carcinomas in relation to LET

A. Takahashi, T. Ohnishi, H. Matsumoto, 2001, International journal of radiation biology.

Repair pathways independent of the Fanconi anemia nuclear core complex play a predominant role in mitigating formaldehyde-induced DNA damage.

T. Helleday, L. Thompson, A. Takahashi, 2011, Biochemical and biophysical research communications.

Heat induces gammaH2AX foci formation in mammalian cells.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2008, Mutation research.

Usefulness of hexamethylenetetramine as an adjuvant to radiation and cisplatin in the treatment of solid tumors: its independency of p53 status.

A. Takahashi, T. Ohnishi, K. Ono, 2010, Journal of radiation research.

Benzyl isothiocyanate sensitizes human pancreatic cancer cells to radiation by inducing apoptosis.

R. Okayasu, K. Ohnishi, N. Kubota, 2011, International journal of molecular medicine.

p 53-dependent Induction of WAF 1 by Heat Treatment in Human Glioblastoma Cells

A. Takahashi, T. Ohnishi, H. Matsumoto, 1996 .

DNA ligase IV as a new molecular target for temozolomide.

H. Nakase, A. Takahashi, T. Ohnishi, 2009, Biochemical and biophysical research communications.

Low-dose-rate radiation attenuates the response of the tumor suppressor TP53.

A. Takahashi, T. Ohnishi, K. Ohnishi, 1999, Radiation research.

Increased resistance of the radiosensitive M10 mutant cells of the L5178Y mouse lymphoma cell line to heat-induced apoptosis.

A. Takahashi, T. Ohnishi, V. Ostapenko, 1999, Radiation research.

Plastic induction of CD133AC133-positive cells in the microenvironment of glioblastoma spheroids.

K. Ohnishi, N. Kubota, Yoshihiro Fujii, 2014, International journal of oncology.

Glioblastoma cell line shows phenotypes of cancer stem cells in hypoxic microenvironment of spheroids.

K. Ohnishi, J. Sagara, Naomi Tojo, 2021, Biochemical and biophysical research communications.

HYPERTONIC SALINE RESUSCITATION REDUCES APOPTOSIS AND TISSUE DAMAGE OF THE SMALL INTESTINE IN A MOUSE MODEL OF HEMORRHAGIC SHOCK

D. Hoyt, T. Ohnishi, K. Ohnishi, 2003, Shock.

HyperthermicCancerTherapyCombined with Inhibitors Targeted Against Heat-induced Signaling Factors

T. Ohnishi, K. Ohnishi, K. Yuki, 2004 .

Effects of accelerated carbon-ions on growth inhibition of transplantable human esophageal cancer in nude mice.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1998, Cancer letters.

Studies about space radiation promote new fields in radiation biology.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002, Journal of radiation research.

Radiation Biology in Space; DNA Damage and Biological Effects of Space Radiation

A. Takahashi, T. Ohnishi, K. Ohnishi, 2002 .

DNA damage formation and p53 accumulation in mammalian cells exposed to the space environment.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1999, Uchu Seibutsu Kagaku.

Evidence for the Involvement of Double-Strand Breaks in Heat-Induced Cell Killing

Ken Ohnishi, Takeo Ohnishi, Hidenori Tanaka, 2004, Cancer Research.

The dependence of p53 on the radiation enhancement of thermosensitivity at different let.

A. Takahashi, T. Ohnishi, H. Matsumoto, 2000, International journal of radiation oncology, biology, physics.

Time course and spacial distribution of UV effects on human skin in organ culture.

Masakatsu Watanabe, A. Takahashi, T. Ohnishi, 2008, Journal of radiation research.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2004, Cancer letters.

C-terminal peptides of p53 molecules enhance radiation-induced apoptosis in human mutant p53 cancer cells

A. Takahashi, T. Ohnishi, K. Ohnishi, 2004, Apoptosis.

Induction of Radioresistance by a Nitric Oxide-Mediated Bystander Effect

Ken Ohnishi, Takeo Ohnishi, Hideki Matsumoto, 2001, Radiation research.

The biological effects of space radiation during long stays in space.

T. Ohnishi, K. Ohnishi, 2004, Uchu Seibutsu Kagaku.

Effects of telencephalic ablation on short-term memory and attention in goldfish

K. Ohnishi, 1997, Behavioural Brain Research.

Development of thermotolerance requires interaction between polymerase‐β and heat shock proteins

A. Takahashi, T. Ohnishi, K. Ohnishi, 2008, Cancer science.

Role of p53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma

T. Ohnishi, Y. Yura, Y. Fujita, 2009, Radiation oncology.

Restoration by glycerol of p53-dependent apoptosis in cells bearing the mutant p53 gene.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1999, International journal of radiation biology.

Enhancement of Hyperthermia on Radio-Sensitivity

K. Ohnishi, 2016 .

p53- dependent hyperthermic enhancement of tumour growth inhibition by X-ray or carbon-ion beam irradiation

A. Takahashi, T. Ohnishi, H. Matsumoto, 2003, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Hyperthermic enhancement of tumour growth inhibition by accelerated carbon-ions in transplantable human esophageal cancer.

A. Takahashi, T. Ohnishi, H. Matsumoto, 1998, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status.

A. Takahashi, T. Ohnishi, K. Ohnishi, 2010, International journal of oncology.

Telencephalic function implicated in food-reinforced color discrimination learning in the goldfish

K. Ohnishi, 1989, Physiology & Behavior.

LY 294002 , an inhibitor of PI-3 K , enhances heat sensitivity independently of p 53 status in human lung cancer cells

A. Takahashi, T. Ohnishi, K. Ohnishi, 2022 .

Combination of the antivascular agent ZD6126 with hypoxic cytotoxin treatment, with reference to the effect on quiescent tumor cells and the dependency on p53 status of tumor cells.

A. Takahashi, T. Ohnishi, K. Ono, 2005, Oncology reports.

Enhancement of Cancer Cell-Killing Effects of Boron Neutron Capture Therapy by Manipulating the Expression of L-Type Amino Acid Transporter 1

Minoru Suzuki, K. Ohnishi, M. Misawa, 2021, Radiation Research.

Role of p 53 mutation in the effect of boron neutron capture therapy on oral squamous cell carcinoma

T. Ohnishi, Y. Yura, Y. Fujita, 2015 .